Schizophrenia Research-Cognition最新文献_第6页

Effects of modifying the pulse width on cognitive side effects with electroconvulsive therapy for schizophrenia 调整脉冲宽度对精神分裂症电休克治疗认知副作用的影响

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-05-24 DOI: 10.1016/j.scog.2025.100369

Qi Si , Yingbo Dong , Yuting Li , Guoxin Xu , Yilin Tang , Peiyu Cao , Congxin Chen , Fangfang Ren , Runda Li , Yuxiu Sui

Background

The majority of studies have shown substantially reduced cognitive impairment with ultra-brief pulse (UBP) electroconvulsive therapy (ECT) compared to brief pulse (BP) ECT, though the results remain inconclusive.

Methods

This study employed a randomized, double-blind, controlled trial design. A total of 114 patients with schizophrenia (SCZ) were enrolled and received BP ECT (63 participants) or UBP ECT (51 participants). Cognitive function was assessed before and after treatment, with peripheral blood biomarkers and hippocampal magnetic resonance spectroscopy (MRS) data collected concurrently.

Results

No significant baseline differences in demographic or clinical characteristics were observed between the two groups. After the end of ECT sessions, the UBP group and BP group respectively showed advantages in the Trail Making Test (TMT) and Hopkins Verbal Learning Test (HVLT). No between-group differences reached statistical significance in other cognitive tests. The homocysteine, prolactin, inducible nitric oxide synthase and left hippocampal myoinositol (MI) levels were significantly elevated in the UBP group than those in the BP group. Multiple linear regression analysis indicated that right hippocampal MI levels were positively correlated with TMT scores.

Conclusion

There are no significant differences in efficacy between UBP ECT at high-dosage and BP ECT, and further research is required to determine whether this modality can reduce cognitive impairment after treatment.

Clinical trial registration

https://www.chictr.org.cn/showproj.html?proj=243964, registration number: ChiCTR2400091601.

大多数研究表明，与短脉冲（BP）电痉挛治疗相比，超短脉冲（UBP）电痉挛治疗（ECT）大大减少了认知障碍，尽管结果仍不确定。方法采用随机、双盲、对照试验设计。共有114名精神分裂症患者（SCZ）被纳入研究，并接受了BP ECT（63名参与者）或UBP ECT（51名参与者）。治疗前后评估认知功能，同时收集外周血生物标志物和海马磁共振波谱（MRS）数据。结果两组患者在人口学和临床特征方面无显著基线差异。电刺激结束后，UBP组和BP组分别在造径测试（TMT）和霍普金斯语言学习测试（HVLT）中表现出优势。其他认知测试组间差异无统计学意义。UBP组大鼠同型半胱氨酸、催乳素、诱导型一氧化氮合酶和左海马肌醇（MI）水平显著高于BP组。多元线性回归分析表明，右侧海马MI水平与TMT评分呈正相关。结论高剂量UBP ECT与BP ECT的疗效无显著差异，该方式是否能减轻治疗后认知功能障碍仍需进一步研究。临床试验注册https://www.chictr.org.cn/showproj.html?proj=243964，注册号：ChiCTR2400091601。

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引用次数: 0

A transdiagnostic approach to understanding neural responsivity to reward and its links to social motivation 用一种跨诊断的方法来理解神经对奖励的反应及其与社会动机的联系

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-05-22 DOI: 10.1016/j.scog.2025.100367

Amy M. Jimenez , Samuel J. Abplanalp , Naomi I. Eisenberger , William P. Horan , Junghee Lee , Amanda McCleery , Ana Ceci Myers , David J. Miklowitz , Eric A. Reavis , L. Felice Reddy , Jonathan K. Wynn , Michael F. Green

Schizophrenia (SZ) and bipolar disorder (BD) are characterized by social impairments. Social impairment also occurs in the general community. Across clinical and nonclinical groups social impairment may be related to deficits in social approach and/or social avoidance motivation. However, the neural basis of social motivation deficits in SZ and BD is not well understood, nor is it known if they reflect features of the illness or are secondary to other factors such as social isolation. To fill these knowledge gaps, 31 individuals with SZ, 27 with BD, and 42 community comparisons (CCs) completed a team-based task during fMRI in which positive and negative feedback was provided by pictures of teammates or opponents. Importantly, the CC group was enriched for self-reported social isolation. fMRI analyses in five key regions of interest (ROIs; ventral striatum, orbital frontal cortex, insula, dorsal anterior cingulate cortex, amygdala), secondary whole-brain analyses, and associations between ROI activity and social approach/avoidance motivation were performed. Across groups, ventral striatum and amygdala showed greater activation to positive versus negative feedback. In SZ, ventral striatum activity to positive feedback was correlated with social approach motivation. In CCs, amygdala activity during negative feedback was correlated with social avoidance motivation. Whole-brain analyses revealed greater activation in BD compared to SZ and CCs in fronto-parietal regions when feedback was provided by an opponent. Findings support disturbed reward sensitivity as a core component of poor social approach motivation in SZ and offer avenues for future research into neural mechanisms underlying social impairment in BD and the general community.

精神分裂症（SZ）和双相情感障碍（BD）以社交障碍为特征。社交障碍也发生在一般社区。在临床和非临床群体中，社交障碍可能与社交接近和/或社交回避动机的缺陷有关。然而，SZ和BD的社会动机缺陷的神经基础尚不清楚，也不知道它们是否反映了疾病的特征，还是继发于其他因素，如社会孤立。为了填补这些知识空白，31名SZ患者、27名BD患者和42名cc患者在fMRI期间完成了一项基于团队的任务，其中队友或对手的照片提供了积极和消极的反馈。重要的是，CC组在自我报告的社会隔离方面得到了丰富。五个关键兴趣区域的fMRI分析（roi）；腹侧纹状体、眶额叶皮层、脑岛、背前扣带皮层、杏仁核)、二次全脑分析，以及ROI活动与社交接近/回避动机之间的关联。在各组中，腹侧纹状体和杏仁核对积极反馈的激活程度高于消极反馈。在SZ，腹侧纹状体对正反馈的活动与社交趋近动机相关。在CCs中，负面反馈时的杏仁核活动与社交回避动机相关。全脑分析显示，当对手提供反馈时，双脑区比SZ和cc的额顶叶区更活跃。研究结果支持奖励敏感性紊乱是双相障碍患者社会行为动机不良的核心因素，并为未来研究双相障碍和一般社区社会行为障碍的神经机制提供了途径。

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引用次数: 0

The glare illusion in individuals with schizophrenia 精神分裂症患者的眩光错觉

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-05-19 DOI: 10.1016/j.scog.2025.100366

Hideki Tamura , Aiko Hoshino

Individuals with schizophrenia are known to display unique reactions to visual illusions, and prior research has indicated a potential link between their increased susceptibility to geometric illusions and specific symptom profiles. While various illusory experiences have been examined among individuals with schizophrenia, their responses to brightness-related illusions remain poorly understood. In this study, we investigated how individuals with schizophrenia perceive the glare illusion, in which the apparent brightness of the central region is increased. A total of 30 patients with schizophrenia and 34 control participants were recruited. During each trial, a glare or control image (standard stimulus) was presented alongside a control image (comparison stimulus) with one of seven luminance levels. In the glare condition, the standard stimulus was a glare image; in the control condition, two control images were presented, but only the luminance of the comparison stimulus varied. The participants were asked to judge which central region appeared brighter. The results revealed that individuals with schizophrenia exhibited greater susceptibility to the glare illusion than did the control participants. However, no significant associations were found between susceptibility to the glare illusion and scores assessing symptom severity. These findings suggest that differences in visual processing in patients with schizophrenia may increase their susceptibility to brightness illusions, although this phenomenon is independent of symptom characteristics. This information may provide a basis for exploring illusion susceptibility as a potential behavioral index for distinguishing between individuals with schizophrenia and control participants.

众所周知，精神分裂症患者对视觉错觉表现出独特的反应，先前的研究表明，他们对几何错觉的易感性增加与特定症状之间存在潜在的联系。虽然对精神分裂症患者的各种幻觉经历进行了研究，但他们对与亮度相关的幻觉的反应仍然知之甚少。在这项研究中，我们调查了精神分裂症患者如何感知眩光错觉，其中中央区域的表观亮度增加。总共招募了30名精神分裂症患者和34名对照参与者。在每次试验中，一个眩光或对照图像（标准刺激）与一个具有七个亮度水平之一的对照图像（比较刺激）一起呈现。眩光条件下，标准刺激为眩光图像；在控制条件下，呈现两幅对照图像，但只有比较刺激的亮度发生变化。参与者被要求判断哪个中心区域看起来更亮。结果显示，精神分裂症患者比对照组更容易出现眩光错觉。然而，在对眩光错觉的易感性和评估症状严重程度的得分之间没有发现显著的关联。这些发现表明，精神分裂症患者的视觉加工差异可能会增加他们对亮度错觉的易感性，尽管这种现象与症状特征无关。这些信息可能为探索幻觉易感性作为区分精神分裂症个体和对照组参与者的潜在行为指标提供基础。

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引用次数: 0

Cognition as a predictor of social network size and early communication in clinically high risk for psychosis individuals 认知作为精神病临床高危个体社会网络大小和早期沟通的预测因子

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-05-08 DOI: 10.1016/j.scog.2025.100365

Nashya Linares , Danielle N. Pratt , Katherine S.F. Damme , Vijay A. Mittal

Social networks provide critical support, yet individuals at clinical high-risk for psychosis (CHR) often experience deficits in social functioning and have smaller networks compared to healthy controls (HCs). Cognitive impairment, a hallmark characteristic of this group, may be associated with these challenges. This study is the first investigation into the relationships between general and specific domains of cognition and social network and communication abilities in people at CHR. The sample included 91 participants (HC = 43, CHR = 48) with complete cognitive and social network assessments from the same visit, with additional analyses including guardian ratings of social responsiveness and communication. Cognitive ability was significantly associated with social network size in both groups (b = 0.38, p < .0001), with significant contributions from working memory (b = 0.29, p = .004), speed of processing (b = 0.23, p = 002), verbal learning (b = 0.24, p = .007), and social cognition (b = 0.25, p = .012). Higher scores on cognitive functioning correlated with better social reciprocity (b = 1.28, p = .009) and fewer communication difficulties (b = 0.25, p < .002). Processing speed was particularly relevant to both social responsiveness (b = 0.88, p < .022) and communication difficulties (b = 0.12, p < .03). An interaction effect revealed that associations between cognitive ability on communication skills were more pronounced in CHR individuals compared to HCs (b = 0.26, p < .037). These findings underscore the potential role of specific cognitive domains, such as processing speed, in social functioning among CHR individuals. Future research should examine the directionality of these relationships to better understand underlying mechanisms of social functioning impairments and inform treatment development.

社会网络提供了关键的支持，然而临床精神病高危人群（CHR）往往经历社会功能缺陷，与健康对照组（hc）相比，他们的社会网络更小。认知障碍，这一群体的一个标志性特征，可能与这些挑战有关。本研究首次调查了CHR人员的一般认知和特定认知领域与社会网络和沟通能力之间的关系。样本包括91名参与者（HC = 43, CHR = 48），他们在同一次访问中进行了完整的认知和社会网络评估，并进行了额外的分析，包括监护人对社会反应性和沟通的评分。两组的认知能力与社会网络规模显著相关(b = 0.38, p <；.0001)，其中工作记忆（b = 0.29, p = 0.004）、加工速度（b = 0.23, p = 002）、言语学习（b = 0.24, p = 0.007）和社会认知（b = 0.25, p = 0.012）的贡献显著。认知功能得分越高，社会互惠性越好（b = 1.28, p = 0.009），沟通困难越少(b = 0.25, p <；.002)。处理速度与社会反应特别相关(b = 0.88, p <；.022)和沟通困难(b = 0.12, p <；03)。交互效应显示，认知能力与沟通技巧之间的关联在高智商人群中更为显著(b = 0.26, p <；.037)。这些发现强调了特定认知领域的潜在作用，如处理速度，在CHR个体的社会功能中。未来的研究应该检查这些关系的方向性，以更好地了解社会功能障碍的潜在机制，并为治疗发展提供信息。

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引用次数: 0

Assessment of the German Version of Brief Assessment of Cognition in Schizophrenia (BACS) 精神分裂症患者认知能力简要评估量表（BACS）德文版本的评估

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-04-30 DOI: 10.1016/j.scog.2025.100364

Matin Mortazavi , Jakob Amon , Iris Jäger , Genc Hasanaj , Zahra Aminifarsani , Kristin Fischer , Matthias Gamer , CDP Working Group , Alkomiet Hasan , Richard S.E. Keefe , Gabriele Sachs , Peter Falkai , Daniel Keeser , Florian Raabe , Elias Wagner

Background

Cognitive impairments are a hallmark of schizophrenia-spectrum disorders (SSD), contributing to poor treatment outcomes and a key treatment target. The Brief Assessment of Cognition in Schizophrenia (BACS) battery is a validated tool designed to evaluate affected core domains in SSD. The present study evaluated psychometric properties of the German version of the BACS in a representative sample of individuals with SSD and healthy control subjects.

Methods

N = 107 individuals with SSD and n = 175 healthy controls were assessed with the German version of the BACS. Diagnosis was confirmed with the Mini International Neuropsychiatric Interview according to DSM-V. Validity was assessed through pair-wise comparisons between SSD individuals and healthy controls and by using receiver operating characteristic analysis. Internal consistency as a measure of reliability was evaluated using McDonald's Omega and Cronbach's Alpha in addition to factor and principal component analysis.

Results

All individuals with SSD exhibited significantly lower z-scores across all BACS subtests and BACS composite scores (Z < -1.5) compared to healthy controls. ROC analysis revealed good diagnostic accuracy with an AUC of 0.83 (95%CI: 0.78,0.88, sensitivity = 0.75, specificity = 0.75). Similar results were observed in sub-cohorts comprising clinically stable SSD patients and those with younger ages (18–35 years old). A unidimensional structure, supported by McDonald's Omega (ω = 0.72) and principal component analysis, confirmed robust internal reliability.

Conclusions

The German BACS demonstrates strong validity and internal reliability when assessed in a representative case-control sample. This study provides an extensive normative dataset for individuals with SSD in German-speaking populations, facilitating future research and clinical assessments of cognition.

认知障碍是精神分裂症谱系障碍（SSD）的一个标志，导致治疗效果不佳，也是一个关键的治疗目标。精神分裂症认知简要评估（BACS）是一种经过验证的工具，旨在评估SSD中受影响的核心领域。本研究在SSD患者和健康对照者的代表性样本中评估了德语版BACS的心理测量特性。方法采用德国版BACS量表对107例SSD患者和175例健康对照者进行评估。根据DSM-V的迷你国际神经精神病学访谈确诊。通过SSD个体与健康对照的两两比较以及受试者工作特征分析来评估有效性。除了因子分析和主成分分析外，还使用McDonald's Omega和Cronbach's Alpha来评估内部一致性作为可靠性的度量。结果所有患有SSD的个体在所有BACS子测试和BACS综合测试中均表现出较低的Z分数(Z <；-1.5)，与健康对照组相比。ROC分析显示良好的诊断准确性，AUC为0.83 （95%CI: 0.78,0.88，敏感性= 0.75，特异性= 0.75）。在包括临床稳定的SSD患者和年龄较小的患者（18-35岁）的亚队列中也观察到类似的结果。麦当劳ω (ω = 0.72)和主成分分析支持的一维结构证实了稳健的内部信度。结论德国BACS在具有代表性的病例对照样本中表现出较强的效度和内部信度。本研究为德语人群中患有SSD的个体提供了广泛的规范数据集，促进了未来的研究和认知的临床评估。

{"title":"Assessment of the German Version of Brief Assessment of Cognition in Schizophrenia (BACS)","authors":"Matin Mortazavi , Jakob Amon , Iris Jäger , Genc Hasanaj , Zahra Aminifarsani , Kristin Fischer , Matthias Gamer , CDP Working Group , Alkomiet Hasan , Richard S.E. Keefe , Gabriele Sachs , Peter Falkai , Daniel Keeser , Florian Raabe , Elias Wagner","doi":"10.1016/j.scog.2025.100364","DOIUrl":"10.1016/j.scog.2025.100364","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive impairments are a hallmark of schizophrenia-spectrum disorders (SSD), contributing to poor treatment outcomes and a key treatment target. The Brief Assessment of Cognition in Schizophrenia (BACS) battery is a validated tool designed to evaluate affected core domains in SSD. The present study evaluated psychometric properties of the German version of the BACS in a representative sample of individuals with SSD and healthy control subjects.</div></div><div><h3>Methods</h3><div><em>N</em> = 107 individuals with SSD and <em>n</em> = 175 healthy controls were assessed with the German version of the BACS. Diagnosis was confirmed with the Mini International Neuropsychiatric Interview according to DSM-V. Validity was assessed through pair-wise comparisons between SSD individuals and healthy controls and by using receiver operating characteristic analysis. Internal consistency as a measure of reliability was evaluated using McDonald's Omega and Cronbach's Alpha in addition to factor and principal component analysis.</div></div><div><h3>Results</h3><div>All individuals with SSD exhibited significantly lower z-scores across all BACS subtests and BACS composite scores (Z < -1.5) compared to healthy controls. ROC analysis revealed good diagnostic accuracy with an AUC of 0.83 (95%CI: 0.78,0.88, sensitivity = 0.75, specificity = 0.75). Similar results were observed in sub-cohorts comprising clinically stable SSD patients and those with younger ages (18–35 years old). A unidimensional structure, supported by McDonald's Omega (ω = 0.72) and principal component analysis, confirmed robust internal reliability.</div></div><div><h3>Conclusions</h3><div>The German BACS demonstrates strong validity and internal reliability when assessed in a representative case-control sample. This study provides an extensive normative dataset for individuals with SSD in German-speaking populations, facilitating future research and clinical assessments of cognition.</div></div>","PeriodicalId":38119,"journal":{"name":"Schizophrenia Research-Cognition","volume":"41 ","pages":"Article 100364"},"PeriodicalIF":2.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired non-verbal auditory memory maintenance in schizophrenia: An ERP study 精神分裂症非言语记忆维持受损：一项ERP研究

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-04-17 DOI: 10.1016/j.scog.2025.100362

Lei Liu , Wenyang Han , Juntao Yu , Lingna Lou , Dewen Zhou , Liang Li , Peng Xu , Feng Zou

Individuals with schizophrenia (SZ) exhibit deficits in speech perception in noise, which are closely related to their abnormalities in auditory working memory (WM). Auditory WM, especially the non-verbal auditory WM, serves as a bridge between perception, action, and long-term memory, playing a crucial role in integrating sound sequences to facilitate auditory object perception and auditory scene analysis (ASA). Although considerable research has been conducted on auditory sensory memory and visual WM in schizophrenia, studies specifically addressing non-verbal auditory WM remain scarce. Therefore, this study recorded the behavioral performance and event related potentials of 36 SZ and 36 healthy controls (HC) during a modified non-musical tone-sequence delayed matching-to-sample task (DMTS). The results showed that, in the tone-sequence DMTS, SZ had not only lower accuracy but also slower reaction times compared to the HC. More importantly, during the retention period, the memory maintenance of SZ begins to decay rapidly from the mid-stage, manifested by a significantly reduction in the late sustained anterior negativity (SAN2). Meanwhile, the early sustained anterior negativity (SAN1) in patients showed a significant correlation with their general pathological symptoms. The pathological symptoms can be predicted by the SAN1 under load 4 condition. This study provides empirical evidence for the impairment of non-verbal auditory WM maintenance in schizophrenia, which is of significant importance for understanding the auditory dysfunction and ASA difficulties experienced by SZ.

精神分裂症患者在噪声环境下的言语感知缺陷与其听觉工作记忆（WM）异常密切相关。听觉WM，尤其是非言语听觉WM，是连接感知、动作和长期记忆的桥梁，在整合声音序列以促进听觉对象感知和听觉场景分析（ASA）中起着至关重要的作用。尽管对精神分裂症患者的听觉记忆和视觉脑损伤进行了大量的研究，但专门针对非言语听觉脑损伤的研究仍然很少。因此，本研究记录了36名SZ和36名健康对照（HC）在改进的非音乐音调序列延迟匹配-样本任务（DMTS）中的行为表现和事件相关电位。结果表明，在音调序列DMTS中，与HC相比，SZ不仅准确率较低，而且反应时间较慢。更重要的是，在保留期，SZ的记忆维持从中期开始迅速衰退，表现为后期持续前负性（SAN2）的显著减少。同时，患者早期持续前路阴性（SAN1）与其一般病理症状有显著相关性。负荷4条件下，SAN1可以预测病理症状。本研究为精神分裂症非言语听觉WM维持障碍提供了经验证据，对理解SZ的听觉功能障碍和ASA困难具有重要意义。

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引用次数: 0

Subjective cognition in schizophrenia and bipolar disorder: Complaints with SSTICS & SACCS 精神分裂症和双相情感障碍的主观认知：对 SSTICS 和 SACCS 的抱怨

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-04-15 DOI: 10.1016/j.scog.2025.100354

Emmanuel Stip , Fadwa Al Mugaddam , Karim Abdel Aziz , Syed Fahad Javaid , Javaid Nauman , Iffat ElBarazi , Stéphane Potvin , Valérie Tourjman , Naomi White

引用次数: 0

Domain-specific associations between social cognition and aggression in schizophrenia spectrum disorders 精神分裂症谱系障碍中社会认知与攻击行为之间的特定领域关联

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-04-09 DOI: 10.1016/j.scog.2025.100361

Sarah A. Berretta , Lindsay D. Oliver , Courtland S. Hyatt , Ricardo E. Carrión , Katrin Hänsel , Aristotle Voineskos , Robert W. Buchanan , Anil K. Malhotra , Sunny X. Tang

Aggression in schizophrenia spectrum disorders (SSD) is rare but elevated relative to the general population. Existing studies have not identified reliable personal predictors of aggression in SSD. In line with social information processing models suggesting that difficulties interpreting social cues and others' intentions may lead to aggression, we evaluated whether social cognitive domains or global social cognition could be modifiable risk factors in SSD.

We examined aggression and social cognition in 59 participants with SSD and 43 healthy volunteers (HV). Self-reported aggression was measured via the Reactive-Proactive Aggression Questionnaire (RPAQ). Social cognition was assessed using five tasks measuring emotion processing, theory of mind, and social perception. Group differences were analyzed using Mann-Whitney-Wilcoxon tests. Multiple regressions examined effects of social cognition on aggression, controlling for demographic and clinical covariates. Supplemental mediation analyses tested whether impairments in emotion processing, theory of mind, or overall social cognition explained the relationship between SSD diagnosis and increased aggression.

Reported aggression was higher in the SSD group, and social cognitive abilities were impaired across domains (p < .001). Better emotion processing (β = −0.35, p = .03) and theory of mind (β = −0.32, p = .03) predicted lower aggression in SSD, even when accounting for demographic and neurocognitive variables. Exploratory models adjusting for overall psychiatric symptom severity showed that theory of mind remained significant, while emotion processing attenuated. However, social cognition did not mediate the relationship between diagnosis and aggression. Future studies should examine other social processing factors, such as attributional bias.

在精神分裂症谱系障碍（SSD）攻击是罕见的，但相对于一般人群升高。现有的研究尚未确定SSD患者攻击行为的可靠的个人预测因素。社会信息加工模型表明，难以解释社会线索和他人意图可能导致攻击，我们评估了社会认知领域或整体社会认知是否可能是SSD的可改变的危险因素。我们对59名SSD参与者和43名健康志愿者（HV）的攻击行为和社会认知进行了研究。采用反应-主动攻击问卷（RPAQ）对自述攻击行为进行测量。社会认知是通过五个任务来评估的：情绪处理、心理理论和社会知觉。采用Mann-Whitney-Wilcoxon检验分析组间差异。多元回归检验了社会认知对攻击行为的影响，控制了人口统计学和临床协变量。补充调解分析测试了情绪处理、心理理论或整体社会认知的损伤是否解释了SSD诊断与攻击增加之间的关系。SSD组报告的攻击性更高，社会认知能力在各个领域都受到损害(p <；措施)。更好的情绪处理（β = - 0.35, p = .03）和心理理论（β = - 0.32, p = .03）预示着SSD患者更低的攻击性，即使考虑到人口统计学和神经认知变量。调整整体精神症状严重程度的探索性模型显示，心理理论仍然显著，而情绪加工减弱。然而，社会认知并没有中介诊断与攻击之间的关系。未来的研究应该考察其他社会加工因素，如归因偏见。

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引用次数: 0

Corrigendum to “A cross-sectional study on the association between executive functions and social disabilities in people with a psychotic disorder” [Schizophr. Res. Cogn. Volume 40 (2025), article number: 100349] “精神障碍患者执行功能与社交障碍之间关联的横断面研究”的勘误[精神分裂症]。Cogn >,第40卷（2025），文章编号：100349]

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-04-03 DOI: 10.1016/j.scog.2025.100360

B.C. van Aken , R. Rietveld , A.I. Wierdsma , Y. Voskes , G.H.M. Pijnenborg , J. van Weeghel , C.L. Mulder

引用次数: 0

Brain functional connectivity associated with cognitive deficits in younger patients at first episode of schizophrenia 年轻精神分裂症首发患者脑功能连通性与认知缺陷相关

IF 2.3 Q2 PSYCHIATRY

Schizophrenia Research-Cognition

Pub Date : 2025-03-31 DOI: 10.1016/j.scog.2025.100359

Na Liu , Lihua Xu , Xiaofeng Guan , Ansi Qi , Fei Liu , Chengqing Yang , Xiangyun Long , Junjuan Zhu , Nan Huang , Jie Zhang , Yi Xu , Jing Chen , Huan Huang , Jijun Wang , Zheng Lu

Background

Cognitive deficits are a core feature of schizophrenia and are influenced by the age at onset of psychosis. Both preclinical and early-onset schizophrenia patients exhibit abnormalities in the frontal cortex, parahippocampus, precuneus, and hippocampus—regions that are closely associated with cognitive deficits. This study examines whether cognitive-related functional connectivity (FC) within these regions differs in first-episode schizophrenia (FES) patients with varying ages of onset.

Methods

FES patients (ages 18–45, n = 24) and matched healthy controls (HC, n = 29) were divided into younger and older subgroups based on the median age of 25 years: FES_young, FES_older, HC_young, and HC_older. All participants completed the MATRICS Consensus Cognitive Battery (MCCB) and underwent resting-state functional magnetic resonance imaging. FC within regions of interest (ROIs) was analyzed using the CONN toolbox.

Results

Significant cognitive differences were observed between the four groups (H = 13.447, p = 0.004, Rank ε² = 0.259). The most prominent differences were found between the FES_young and HC_young groups (Holm-adjusted p = 0.012). Cognitive deficits in FES patients were significantly associated with reduced FC between the right precuneus (A31_R) and right parahippocampal gyrus (TI_R) (rho = 0.549, p = 0.010, Fisher's z = 0.616). FES_young showed significantly lower FC between A31_R and TI_R compared to HC_young (Holm-adjusted p = 0.001).

Conclusion

Earlier onset schizophrenia is associated with more severe cognitive deficits and specific impairments in brain functional connectivity. These findings highlight the importance of considering age of onset when assessing cognitive and neural dysfunction in schizophrenia.

背景认知缺陷是精神分裂症的核心特征，并受精神病发病年龄的影响。临床前和早发性精神分裂症患者都表现出额叶皮质、副海马体、楔前叶和海马体的异常，这些区域与认知缺陷密切相关。本研究探讨了不同发病年龄的首发精神分裂症（FES）患者在这些区域的认知相关功能连接（FC）是否存在差异。方法sfes患者（18-45岁，n = 24）和匹配的健康对照（HC, n = 29）按中位年龄（25岁）分为FES_young、FES_older、HC_young和HC_older两组。所有的参与者都完成了矩阵共识认知电池（MCCB），并进行了静息状态功能磁共振成像。使用CONN工具箱分析感兴趣区域（roi）内的FC。结果四组患者认知能力差异有统计学意义（H = 13.447, p = 0.004, Rank ε2 = 0.259）。FES_young组和HC_young组之间的差异最为显著（经holm校正p = 0.012）。FES患者的认知缺陷与右侧楔前叶（A31_R）和右侧海马旁回（TI_R）之间的FC减少显著相关（rho = 0.549, p = 0.010, Fisher’s z = 0.616）。与HC_young相比，FES_young显示A31_R和TI_R之间的FC显著降低（经holm校正p = 0.001）。结论早发性精神分裂症与更严重的认知缺陷和脑功能连接特异性损伤相关。这些发现强调了在评估精神分裂症的认知和神经功能障碍时考虑发病年龄的重要性。

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引用次数: 0