Materials & Design最新文献_第2页

A sponge scaffold with microchannels to accelerate bone repair 带微通道的海绵支架，加速骨修复

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.matdes.2026.115598

Lei Luo , Xiaoyu Wu , Ye Zhu , Yurong Chen , Bin Zhu , Yining Gong , Raghvendra Bohara , Dali He , Yazhong Bu , Liang Yan

The field of bone defect repair continues to face numerous challenges. Therefore, the development of effective bone regeneration materials remains urgently needed. This study fabricated a microchannel sponge scaffold (MS) with the assistance of 3D printing. Experimental results showed that MS increased clot porosity and mechanical stability. And MS-treated blood clots significantly enhanced cell migration compared with ordinary clots. In in vitro cell experiments, the MS loaded with blood clots and vascular endothelial growth factor (VEGF) significantly upregulated the expression levels of osteogenesis- and angiogenesis-related genes, promoting both angiogenesis as well as osteogenic differentiation. In vivo hemostasis experiments revealed that the MS significantly reduced blood loss and hemostasis time, when compared with commercially available gelatin hemostatic sponges (C-Sponge). Furthermore, in vivo experiments utilizing a rat cranial defect model indicated that the MS provided substantial support for bone defects and stimulated bone tissue formation. At 8 weeks post-transplantation, the Blood-UMS600-V group had the highest Bone Mineral Density (BMD) and Bone Volume Fraction (BV/TV) with significant differences from other groups. Histological staining revealed accelerated bone repair mechanisms involving increased collagen deposition and enhanced angiogenesis. Conclusively, MS holds clinical potential for treating bone defect bleeding and improving bone healing.

骨缺损修复领域继续面临诸多挑战。因此，迫切需要开发有效的骨再生材料。本研究利用3D打印技术制备了一种微通道海绵支架（MS）。实验结果表明，质谱提高了凝块的孔隙度和力学稳定性。与普通血块相比，经ms处理的血凝块显著增强了细胞迁移。在体外细胞实验中，载血凝块和血管内皮生长因子（VEGF）的MS显著上调成骨和血管生成相关基因的表达水平，促进血管生成和成骨分化。体内止血实验显示，与市售明胶止血海绵（C-Sponge）相比，MS显著减少了出血量和止血时间。此外，利用大鼠颅骨缺损模型进行的体内实验表明，MS对骨缺损提供了实质性的支持，并刺激了骨组织的形成。移植后8周，Blood-UMS600-V组骨密度（BMD）和骨体积分数（BV/TV）最高，与其他各组差异有统计学意义。组织学染色显示加速骨修复机制包括增加胶原沉积和增强血管生成。总之，MS具有治疗骨缺损出血和改善骨愈合的临床潜力。

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引用次数: 0

Multifunctional carbon-veil grid design for impact damage monitoring and tolerance in GFRP and CFRP laminates GFRP和CFRP复合材料冲击损伤监测与容限的多功能碳膜网格设计

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.matdes.2026.115608

Ozan Can Zehni , Ali Kandemir

This study presents a materials-by-design strategy based on fully embedded carbon-veil grid architectures for high-sensitivity impact damage monitoring in glass- and carbon-fibre-reinforced polymer (GFRP and CFRP) laminates. Integrated as part of the laminate, the architecture exploits high-frequency resistance monitoring to capture transient electrical responses during impact, enabling detection of damage initiation at very low energy levels. In GFRP laminates, lightweight 10 g/m² carbon-veil grids produced repeatable and spatially resolved resistance responses under low-velocity impacts between 5 and 20 J. Distinct transient resistance signatures were detected even at 5 J, revealing sensitivity to early-stage matrix cracking beyond conventional post-impact measurements. With increasing impact energy, transient and permanent resistance changes increased markedly, reaching very large amplitudes at 20 J due to extensive delamination and grid disruption. In CFRP laminates, electrically insulated 2 g/m² carbon-veil grids combined with thermoplastic veils enabled detection of subsurface and through-thickness damage at energies as low as 3 J, even in the absence of visible ultrasonic indications. Joule-heating-assisted thermal imaging provided direct visualisation of electrically damaged regions, while short-beam shear tests showed an approximately 11 % enhancement in interlaminar shear strength. The architecture enables early impact damage detection, severity discrimination, and mechanical enhancement in composite laminates.

本研究提出了一种基于全嵌入式碳膜网格结构的材料设计策略，用于玻璃和碳纤维增强聚合物（GFRP和CFRP）层叠板的高灵敏度冲击损伤监测。作为层压板的一部分，该结构利用高频电阻监测来捕捉撞击过程中的瞬态电响应，从而在非常低的能量水平下检测到损伤的发生。在GFRP层叠板中，轻质的10 g/m2碳膜网格在5到20 J的低速冲击下产生了可重复的和空间分辨的电阻响应，即使在5 J的情况下也检测到明显的瞬态电阻特征，揭示了对早期基体开裂的敏感性，超出了传统的冲击后测量。随着冲击能量的增加，瞬态和永久电阻变化显著增加，在20 J时由于广泛的分层和网格破坏而达到非常大的幅度。在CFRP层叠板中，电绝缘的2g /m2碳膜网格与热塑性薄膜相结合，即使在没有可见超声指示的情况下，也能在低至3j的能量下检测到地下和穿透厚度的损伤。焦耳加热辅助热成像提供了电损伤区域的直接可视化，而短束剪切测试显示层间剪切强度提高了约11%。该架构可实现复合材料层压板的早期冲击损伤检测、严重程度判别和机械增强。

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引用次数: 0

Modular metamaterials with deep learning–enabled customizable stress–strain responses 具有深度学习功能的可定制应力应变响应的模块化超材料

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.matdes.2026.115584

Xiaofeng Guo , Miaomiao He , Ikumu Watanabe , Jiaxin Zhou , Takayuki Yamada , Yong Yi , Xiaoyang Zheng

Modular mechanical metamaterials offer unique opportunities for programmable and reconfigurable functionality through simple geometric rearrangements. Inspired by the modularity of Lego blocks, we propose a new class of modular metamaterials composed of three standardized modules—linear, yielding-like, and snap-through buckling elements—that can be assembled into two- and three-dimensional grids to realize diverse nonlinear stress–strain responses. To accelerate design and optimization, we integrate deep learning (DL) with the metamaterial design process. A convolutional neural network-based predictor rapidly estimates the stress–strain curves of given modular configurations, achieving a prediction accuracy of

R^{2} > 0.999

. Furthermore, a conditional variational autoencoder-based inverse designer enables the automatic generation of modular configurations that match target stress–strain curves, demonstrating high fidelity (

R^{2} \approx 0.97

). The proposed DL framework allows rapid, scalable, and reprogrammable design of nonlinear mechanical responses without exhaustive simulations or manual tuning. This study establishes a universal, data-driven strategy for the inverse design of modular metamaterials, paving the way toward intelligent, reconfigurable material systems for applications in soft robotics and adaptive structures.

模块化机械超材料通过简单的几何重排为可编程和可重构功能提供了独特的机会。受乐高积木模块化的启发，我们提出了一种新的模块化超材料，由三个标准化模块组成——线性模块、类屈服模块和卡扣模块——它们可以组装成二维和三维网格，以实现不同的非线性应力-应变响应。为了加速设计和优化，我们将深度学习（DL）与超材料设计过程相结合。基于卷积神经网络的预测器快速估计给定模态的应力应变曲线，预测精度为R2>；0.999。此外，基于条件变分自编码器的逆设计器能够自动生成匹配目标应力-应变曲线的模块化配置，具有高保真度（R2≈0.97）。提出的深度学习框架允许快速，可扩展和可重新编程的非线性机械响应设计，而无需详尽的模拟或手动调整。本研究为模块化超材料的逆向设计建立了一种通用的、数据驱动的策略，为柔性机器人和自适应结构应用的智能、可重构材料系统铺平了道路。

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引用次数: 0

Metabolically targeted NIR-II theranostic nanoplatform enabling efficient synergistic phototherapy and chemotherapy for Alveolar echinococcosis 代谢靶向NIR-II治疗纳米平台，为肺泡棘球蚴病提供有效的协同光疗和化疗

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-31 DOI: 10.1016/j.matdes.2026.115597

Zenghao Zhao , Bingshuai Zhou , Jun Li , Meiling Wang , Chi Zhang , Jiabao Xiong , Zhong Du , Wenbao Zhang , Biao Dong , Nuernisha Alifu

Alveolar echinococcosis (AE) is a malignant tumor-like parasitic disease whose treatment is limited by poor lesion accessibility and insufficient chemotherapeutic efficacy. Herein, a metabolic-targeted NIR-II theranostic nanoplatform was rationally designed to integrate photothermal therapy (PTT), photodynamic therapy (PDT), and chemotherapy for AE treatment. The Au@Si@ABZSO/ICG@P nanoparticles (ASAIP NPs) feature a gold nanorod core for efficient photothermal conversion, a mesoporous silica layer for co-loading albendazole sulfoxide (ABZSO) and indocyanine green (ICG), and a poly (lactic-co-glycolic acid) shell enabling preferential hepatic lesion accumulation via metabolic affinity. NIR-II fluorescence imaging allows accurate lesion visualization and guides spatiotemporally controlled therapy. Under photothermal activation, on-demand ABZSO release is achieved, while ICG simultaneously mediates PTT and PDT, producing enhanced synergistic antiparasitic effects. This work demonstrates a metabolically targeted, multimodal nanoplatform that improves therapeutic precision and efficacy against AE.

肺泡棘球蚴病（Alveolar echinoccocosis， AE）是一种恶性肿瘤样寄生虫病，其治疗受到病灶可及性差和化疗疗效不足的限制。本文合理设计了代谢靶向NIR-II治疗纳米平台，将光热疗法（PTT）、光动力疗法（PDT）和化疗相结合，用于AE治疗。Au@Si@ABZSO/ICG@P纳米颗粒（ASAIP NPs）具有用于高效光热转换的金纳米棒核心，用于共负载阿苯达唑亚砜（ABZSO）和吲哚青绿（ICG）的介孔二氧化硅层，以及通过代谢亲和作用优先积累肝脏病变的聚乳酸-共乙醇酸壳。NIR-II荧光成像允许准确的病变可视化和指导时空控制治疗。在光热激活下，ABZSO按需释放，而ICG同时介导PTT和PDT，产生增强的协同抗寄生虫作用。这项工作证明了一种代谢靶向的多模态纳米平台，可以提高AE的治疗精度和疗效。

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引用次数: 0

Recent advances in reinforced honeycomb mechanical metamaterials: a review 增强蜂窝机械超材料研究进展综述

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115593

Zhenzhen Cai, Xiaolin Deng

Honeycomb structures, as a class of ultra-lightweight mechanical metamaterials, achieve their exceptional mechanical performance predominantly through the carefully engineered geometry of their cellular architecture, rather than solely through the intrinsic properties of the constituent materials. While the intrinsic mechanical properties of the base material—such as stiffness and strength—also influence the overall response, their contribution is generally secondary to that of the structural configuration. This review systematically summarizes the major advancements in honeycomb structure design, with a focus on reinforced two-dimensional geometric configurations aimed at developing new cellular architectures with diversified and optimized mechanical properties. The paper first revisits the classical honeycomb topologies, then discusses the crashworthiness of traditional concave hexagonal honeycombs and their common improvement strategies. Furthermore, a clear classification framework is established according to design scale. Reinforced macroscopic designs are categorized into hierarchical, graded, curved, foam-filled, hybrid, and symmetric/asymmetric configurations. The review also explores the influence mechanisms of critical loading parameters and geometric characteristics, along with a summary of mainstream manufacturing techniques and their practical applications. Finally, the paper highlights key design trends and future challenges in improving the mechanical performance of honeycomb structures, providing insights into advancing collision safety and structural resilience.

蜂窝结构作为一种超轻量的机械超材料，其卓越的机械性能主要是通过其蜂窝结构的精心设计的几何形状来实现的，而不仅仅是通过组成材料的内在特性。虽然基础材料的内在力学性能（如刚度和强度）也会影响整体响应，但它们的作用通常次于结构配置。本文系统总结了蜂窝结构设计的主要进展，重点是增强二维几何构型，旨在开发具有多样化和优化力学性能的新型蜂窝结构。本文首先回顾了蜂窝的经典拓扑结构，然后讨论了传统凹六边形蜂窝的耐撞性及其改进策略。并根据设计尺度建立了清晰的分类框架。加固宏观设计分为分层、分级、弯曲、泡沫填充、混合和对称/不对称配置。本文还探讨了关键载荷参数和几何特性的影响机制，并对主流制造技术及其实际应用进行了总结。最后，本文强调了改进蜂窝结构力学性能的关键设计趋势和未来挑战，为提高碰撞安全性和结构弹性提供了见解。

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引用次数: 0

Topology optimization design of titanium alloy outer cylinder lug structure for landing gear 起落架钛合金外筒耳结构拓扑优化设计

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1016/j.matdes.2026.115562

Jiale Shi , Zhipeng Li , Zhen Zhuang , Fu Li , Lingbo Zhang , Quhao Li , Yunfeng Luo

While A-100 ultra-high-strength steel is widely employed in landing gear, its mass poses a constraint for advancing aircraft performance. To overcome this, the present research introduces two key innovations: the substitution with a lightweight titanium alloy and the development of an integrated topology and shape optimization framework, specifically applied to the outer cylinder lug. This approach yielded an optimal design that reduces mass by 28.4% and confines the maximum stress to 860.6 MPa, safely under the 875 MPa allowable threshold. A comprehensive experimental validation, involving full-scale static, fatigue, and post-fatigue residual strength tests, was conducted following a complete design-to-test workflow, confirming the design’s practical robustness. The findings underscore that the integrated methodology achieves substantial mass savings while ensuring structural integrity and durability, providing a critical reference for engineering future landing gear components.

虽然a- 100超高强度钢广泛用于起落架，但其质量对提高飞机性能构成了制约。为了克服这个问题，本研究引入了两个关键创新：用轻质钛合金替代，以及开发集成拓扑和形状优化框架，特别是应用于外气缸凸耳。这种方法产生了一个优化设计，减少了28.4%的质量，并将最大应力限制在860.6 MPa，安全低于875 MPa的允许阈值。全面的实验验证，包括全尺寸静态、疲劳和疲劳后残余强度测试，按照完整的设计到测试工作流程进行，确认了设计的实际鲁棒性。研究结果强调，集成方法在确保结构完整性和耐久性的同时，实现了大量的质量节约，为未来起落架部件的工程设计提供了重要参考。

引用次数: 0

Optimized low-temperature heat treatment to enhance the mechanical properties of ceramic-reinforced TWIP steel matrix composites 优化低温热处理工艺，提高陶瓷增强TWIP钢基复合材料的力学性能

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.matdes.2026.115566

Guojin Sun , Qi Wang

This work explores the use of an improved low-temperature heat treatment procedure to improve the mechanical properties of large-sized ceramic-reinforced TWIP (Twinning-Induced Plasticity) steel matrix composites. The results obtained demonstrate that the ceramic-reinforced TWIP composite’s strength and ductility are significantly improved with low-temperature heat treatment, especially at 400 °C. The ductility, which is determined by the displacement at maximum force, improved by more than 40%, while the bending strength increased by more than 200 MPa to reach about 1000 MPa. The mechanical performance improvements in ceramic-reinforced TWIP steel matrix composites can be primarily attributed to the optimization of the TWIP steel matrix through precise heat treatment. The enhancement is the result of the synergistic effects of twin-induced plasticity (TWIP) and precipitation strengthening mechanisms, which have been carefully engineered through the controlled thermal processes. Precipitate clustering at grain boundaries occasioned an apparent change in its mechanical properties as the heat treatment temperature rose over 400 °C, compromising both strength and ductility. The findings offer significant guidance for facilitating the development of high-performance TWIP steel matrix composites in demanding engineering applications through shedding illumination on the relationship between ceramic reinforcement, the application of heat, and microstructural evolution.

本工作探讨了使用改进的低温热处理工艺来改善大尺寸陶瓷增强TWIP（孪生诱导塑性）钢基复合材料的力学性能。结果表明，低温热处理，特别是在400℃时，陶瓷增强TWIP复合材料的强度和塑性得到了显著提高。由最大受力位移决定的延性提高了40%以上，抗弯强度提高了200 MPa以上，达到1000 MPa左右。陶瓷增强TWIP钢基复合材料力学性能的提高主要归功于TWIP钢基通过精密热处理的优化。这种增强是双诱导塑性（TWIP）和沉淀强化机制协同作用的结果，这两种机制都是通过受控的热过程精心设计的。当热处理温度超过400℃时，晶界处的析出相聚集导致其力学性能发生明显变化，强度和延展性均受到影响。该研究结果通过揭示陶瓷增强、热应用和微观组织演变之间的关系，为促进高性能TWIP钢基复合材料在苛刻的工程应用中的发展提供了重要的指导。

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引用次数: 0

Thermosensitive chitosan hydrogel encapsulating exosomes inhibits NLRP3 activation to promote diabetic foot ulcer healing 包封外泌体的热敏壳聚糖水凝胶抑制NLRP3激活促进糖尿病足溃疡愈合

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1016/j.matdes.2026.115561

Xinnan Song , Chenglin Sun , Fei Meng , Xiaohong Zhang , Lixin Yang

The study investigated the therapeutic potential of thermosensitive chitosan hydrogels encapsulating adipose-derived mesenchymal stem cell-derived exosomes (ADMSCs-Exos) for enhancing wound healing in diabetic foot ulcers (DFUs). Hydrogels prepared at varying concentrations were characterized for gelation behavior and structural properties, and Exos were isolated and validated through biomarker analysis. The encapsulated Exos significantly inhibited NLRP3 inflammasome formation and activation in vitro, reducing the expression of NLR family pyrin domain-containing 3 (NLRP3), caspase-1, and interleukin (IL)-1β. Exos also promoted macrophage polarization toward the M2 phenotype, thereby supporting tissue repair. In vivo, the Hydrogel-Exo treatment group demonstrated a 90% wound healing efficiency, demonstrating a statistically significant improvement compared with the control group in DFU models (P < 0.0001). Mechanistic analysis revealed that Exos hindered the interaction between NLRP3, caspase-1, and apoptosis-associated speck-like protein containing a CARD (ASC), which was further confirmed by gene knockouts. This study innovatively combined a thermosensitive chitosan hydrogel with ADMSC-derived exosomes for the treatment of DFU, significantly accelerating wound healing by inhibiting the NLRP3 inflammasome pathway and promoting M2 macrophage polarization. These findings provide new experimental evidence and a potential therapeutic strategy for the clinical application of exosomes in chronic inflammatory diseases.

该研究探讨了热敏壳聚糖水凝胶包封脂肪源性间充质干细胞源性外泌体（ADMSCs-Exos）促进糖尿病足溃疡（DFUs）伤口愈合的治疗潜力。对制备的不同浓度水凝胶的凝胶行为和结构特性进行了表征，并通过生物标志物分析分离并验证了Exos。包封的Exos在体外显著抑制NLRP3炎性体的形成和激活，降低NLR家族pyrin - domain-containing 3 （NLRP3）、caspase-1和白细胞介素(IL)-1β的表达。Exos还促进巨噬细胞向M2表型极化，从而支持组织修复。在体内，水凝胶- exo治疗组伤口愈合效率为90%，在DFU模型中与对照组相比，有统计学意义上的显著改善（P < 0.0001）。机制分析显示，Exos阻碍了NLRP3、caspase-1和含有CARD的凋亡相关斑点样蛋白（ASC）之间的相互作用，基因敲除进一步证实了这一点。本研究创新地将热敏壳聚糖水凝胶与admsc来源的外泌体结合治疗DFU，通过抑制NLRP3炎症小体途径和促进M2巨噬细胞极化显著加速伤口愈合。这些发现为外泌体在慢性炎症性疾病中的临床应用提供了新的实验证据和潜在的治疗策略。

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引用次数: 0

Mechanical properties, corrosion resistance, and corresponding mechanisms of FeCoCrNiMox high-entropy alloys through regulation of the σ phase 通过σ相调控FeCoCrNiMox高熵合金的力学性能、耐蚀性及机理

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-11 DOI: 10.1016/j.matdes.2026.115642

Yuhang Yang , Yugang Miao , Yuyang Zhao , Ji Liu , Lei Liu , Chuanqi Liu , Yifan Wu

This study investigates the effects of Mo content on FeCoCrNiMo_x (x=0, 0.2, 0.5, 0.8) high-entropy alloys fabricated via plasma arc powder-directed energy deposition (PAP-DED). All alloys primarily consist of FCC solid solutions, with σ-phase precipitation increasing with Mo content. Mo addition refines grains and boosts dislocation density up to 2.5×. The alloy with x = 0.2 exhibits optimal performance: yield strength (384 ± 11 MPa), tensile strength (722 ± 12 MPa), and elongation (42.8 ± 2.7%), with strength 2.2–2.3× higher than the Mo-free alloy. Strengthening is dominated by dislocation and precipitation mechanisms. Mo₀.₂ also shows the best corrosion resistance due to Cr-Mo-O protective oxides. Excessive Mo (x = 0.8) degrades both corrosion resistance and mechanical properties due to σ-phase formation, despite enhancing hardness and wear resistance. Wear shifts from abrasive-adhesive to mainly abrasive. This work clarifies strengthening and corrosion mechanisms under PAP-DED, guiding alloy design for additive manufacturing.

研究了Mo含量对等离子弧粉末定向能沉积（PAP-DED）法制备FeCoCrNiMox （x= 0,0.2, 0.5, 0.8）高熵合金的影响。所有合金均以FCC固溶体为主，σ相析出随Mo含量的增加而增加。添加Mo细化晶粒，使位错密度提高2.5倍。x = 0.2合金的屈服强度为384±11 MPa，抗拉强度为722±12 MPa，伸长率为42.8±2.7%，强度比无钼合金高2.2 ~ 2.3倍。强化主要是位错和沉淀机制。由于含有Cr-Mo-O保护氧化物，Mo0.2也表现出最好的耐腐蚀性。过量的Mo （x = 0.8）虽然提高了硬度和耐磨性，但由于σ相的形成，降低了耐腐蚀性和力学性能。磨损从磨料粘合剂转变为主要的磨料。阐明了PAP-DED的强化和腐蚀机理，指导了增材制造合金的设计。

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引用次数: 0

Calcium carbonate nanoplatform for remodeling the tumor microenvironment to enhance Chemo-Immunotherapeutic Synergy in breast cancer 碳酸钙纳米平台重塑肿瘤微环境，增强乳腺癌化疗免疫治疗协同作用

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.matdes.2026.115590

Nannan Zhang , Shengrong Lin , Luqian Gao , Jun Ding , Xiaohui Chen , Long Zhang , Langhai Xu , Shun Li , Xiangmin Tong

Cancer immunotherapy currently represents the only promising strategy with the potential to achieve a complete cure for tumors. Enhancing tumor-specific immune responses and overcoming the immunosuppressive TME are key to improving the efficacy of cancer immunotherapy. In this study, we introduce a calcium carbonate-based nanocarrier capable of modulating the tumor microenvironment. This system is coloaded with L-arginine (L-Arg) and the chemotherapeutic agent doxorubicin (DOX), aiming to optimize the conventional chemoimmunotherapy approach by ameliorating the immunosuppressive tumor microenvironment and regulating immune cell activity, thereby promoting synergistic chemoimmunotherapeutic outcomes. Specifically, DOX directly kills tumor cells and induces immunogenic cell death. Moreover, the calcium carbonate nanocarrier not only serves as a drug delivery vehicle but also neutralizes lactic acid in the tumor tissue, thereby alleviating the acidic immunosuppressive microenvironment. Furthermore, it supplies supplemental arginine within the tumor tissue to increase the activation of effector T cells. Ultimately, this strategy achieves highly efficient antitumor efficacy through the combined and synergistic actions of chemotherapy and immunotherapy.

癌症免疫疗法目前是唯一有希望完全治愈肿瘤的策略。增强肿瘤特异性免疫应答，克服免疫抑制性TME是提高肿瘤免疫治疗效果的关键。在这项研究中，我们介绍了一种能够调节肿瘤微环境的碳酸钙基纳米载体。该系统以l -精氨酸（L-Arg）和化疗药物多柔比星（DOX）为载体，旨在通过改善免疫抑制肿瘤微环境和调节免疫细胞活性来优化传统的化学免疫治疗方法，从而促进化学免疫治疗的协同效果。具体来说，DOX直接杀死肿瘤细胞并诱导免疫原性细胞死亡。此外，碳酸钙纳米载体不仅可以作为药物递送载体，还可以中和肿瘤组织中的乳酸，从而缓解酸性免疫抑制微环境。此外，它在肿瘤组织内提供补充精氨酸，以增加效应T细胞的激活。最终，该策略通过化疗和免疫治疗的联合和协同作用达到高效的抗肿瘤效果。

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引用次数: 0