Materials & Design最新文献

英文中文

In-situ neutron diffraction revealing microstructure changes during laser powder bed fusion and in-situ laser heat treatments of 316L and 316L-Al1

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-13 DOI: 10.1016/j.matdes.2025.113727

Claire Navarre , Shieren Sumarli , Florencia Malamud , Efthymios Polatidis , Markus Strobl , Roland E. Logé

The versatility and flexibility in laser-based layer-wise additive manufacturing processes allow for the fabrication of metallic parts with tailorable mechanical properties. Interest in microstructure control during the process has led to varying applications of laser post-exposure strategies. In this study, in-situ laser heat treatment (LHT) through subsequent laser rescanning on specific layers was performed on 316L and Al-added 316L. In-situ neutron diffraction was carried out in between the LHT steps to qualitatively assess the dislocation density within the probed volume, revealing the influence of process-induced thermal history on the recovery and recrystallization capabilities of these materials. In-situ neutron diffraction during in-situ LHT was realized by using a custom designed laser powder bed fusion system installed on the beamline. Post-mortem measurements followed by microstructural and mechanical analyses shed light on the extensive effect of the in-situ LHT on the final microstructure, validating its ability to promote recovery and recrystallization and, thus, tune the mechanical properties. While microstructural analysis permits observations at the microscopic level, it is destructive, and its local nature may limit reliability. In-situ non-destructive bulk characterization with neutron diffraction enables following the evolutionary process on larger scales, confirming the microstructure evolution phenomena within representative materials volume with greater statistics.

{"title":"In-situ neutron diffraction revealing microstructure changes during laser powder bed fusion and in-situ laser heat treatments of 316L and 316L-Al1","authors":"Claire Navarre , Shieren Sumarli , Florencia Malamud , Efthymios Polatidis , Markus Strobl , Roland E. Logé","doi":"10.1016/j.matdes.2025.113727","DOIUrl":"10.1016/j.matdes.2025.113727","url":null,"abstract":"<div><div>The versatility and flexibility in laser-based layer-wise additive manufacturing processes allow for the fabrication of metallic parts with tailorable mechanical properties. Interest in microstructure control during the process has led to varying applications of laser post-exposure strategies. In this study, in-situ laser heat treatment (LHT) through subsequent laser rescanning on specific layers was performed on 316L and Al-added 316L. In-situ neutron diffraction was carried out in between the LHT steps to qualitatively assess the dislocation density within the probed volume, revealing the influence of process-induced thermal history on the recovery and recrystallization capabilities of these materials. In-situ neutron diffraction during in-situ LHT was realized by using a custom designed laser powder bed fusion system installed on the beamline. Post-mortem measurements followed by microstructural and mechanical analyses shed light on the extensive effect of the in-situ LHT on the final microstructure, validating its ability to promote recovery and recrystallization and, thus, tune the mechanical properties. While microstructural analysis permits observations at the microscopic level, it is destructive, and its local nature may limit reliability. In-situ non-destructive bulk characterization with neutron diffraction enables following the evolutionary process on larger scales, confirming the microstructure evolution phenomena within representative materials volume with greater statistics.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113727"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical and fatigue performance of multidirectional functionally graded Ti6Al4V scaffolds produced via laser powder bed fusion for orthopedic implants

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-13 DOI: 10.1016/j.matdes.2025.113725

Ragul Gandhi , Mika Salmi , Björkstrand Roy , Lehto Pauli , Lorenzo Pagliari , Franco Concli

Orthopedic implants require porosity gradients to achieve tissue integration and mechanical support. This study presents a novel design of Multidirectional Functionally Graded (MDFG) porous Ti6Al4V scaffolds, fabricated via Laser Powder Bed Fusion (LPBF) to mimic natural bone porosity for orthopedic applications. Four scaffold types were developed: Gyroid and Primitive (sheet-based TPMS) and Kelvin and Voronoi (strut-based lattices). A pore size of 1000 µm was maintained to promote tissue ingrowth, while strut thickness grading (0.3–0.7 mm) enhanced mechanical stability. Quasi-static compression tests showed Young’s moduli of 9.5 GPa (Gyroid) and 9.3 GPa (Primitive), with ultimate strengths of 240 MPa and 190 MPa, respectively. Energy absorption was 47.74 MJ/m³ for Gyroid and 46.68 MJ/m³ for Primitive, demonstrating excellent resistance to mechanical failure. Fatigue testing revealed that the Gyroid lattice sustained 25 MPa after one million cycles, highlighting its long-term durability. Fractographic analysis showed that fatigue cracks initiated at surface defects and propagated along strut intersections, providing insights into failure mechanisms. These findings confirm that MDFG scaffolds, particularly Gyroid and Primitive lattices, enhance mechanical robustness and biological compatibility, making them strong candidates for load-bearing orthopedic implants.

{"title":"Mechanical and fatigue performance of multidirectional functionally graded Ti6Al4V scaffolds produced via laser powder bed fusion for orthopedic implants","authors":"Ragul Gandhi , Mika Salmi , Björkstrand Roy , Lehto Pauli , Lorenzo Pagliari , Franco Concli","doi":"10.1016/j.matdes.2025.113725","DOIUrl":"10.1016/j.matdes.2025.113725","url":null,"abstract":"<div><div>Orthopedic implants require porosity gradients to achieve tissue integration and mechanical support. This study presents a novel design of Multidirectional Functionally Graded (MDFG) porous Ti6Al4V scaffolds, fabricated via Laser Powder Bed Fusion (LPBF) to mimic natural bone porosity for orthopedic applications. Four scaffold types were developed: Gyroid and Primitive (sheet-based TPMS) and Kelvin and Voronoi (strut-based lattices). A pore size of 1000 µm was maintained to promote tissue ingrowth, while strut thickness grading (0.3–0.7 mm) enhanced mechanical stability. Quasi-static compression tests showed Young’s moduli of 9.5 GPa (Gyroid) and 9.3 GPa (Primitive), with ultimate strengths of 240 MPa and 190 MPa, respectively. Energy absorption was 47.74 MJ/m<sup>3</sup> for Gyroid and 46.68 MJ/m<sup>3</sup> for Primitive, demonstrating excellent resistance to mechanical failure. Fatigue testing revealed that the Gyroid lattice sustained 25 MPa after one million cycles, highlighting its long-term durability. Fractographic analysis showed that fatigue cracks initiated at surface defects and propagated along strut intersections, providing insights into failure mechanisms. These findings confirm that MDFG scaffolds, particularly Gyroid and Primitive lattices, enhance mechanical robustness and biological compatibility, making them strong candidates for load-bearing orthopedic implants.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113725"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local crack suppression and activation of plastic flow via electron irradiation in oxide glasses

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-13 DOI: 10.1016/j.matdes.2025.113726

Sebastian Bruns, Karsten Durst

The present study demonstrates the potential of electron irradiation for local modification of the mechanical behavior of oxide glasses via In-SEM nanoindentation. The experiments were performed with cube-corner indenter tip under various electron beam conditions on Fused Silica, soda-lime-silica glass and the borosilicate glass Boroplate. The results show that electron irradiation is a powerful tool to locally activate plastic flow processes in order to target crack suppression upon nanoindentation. The glasses deformation resistance (i.e. hardness) can be adjusted with switching the intensity of the electron beam or the strain rate for indentation while changes in elastic modulus remain moderate. The change of the deformation resistance, determined by parameter ΔH/H₀, shows a distinct increase at beam intensities from which on forward crack suppression has been detected, serving as indication for brittle-to-ductile transition.

引用次数: 0

Integrated Computational Materials Engineering of Fire-Resistant Steels

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-13 DOI: 10.1016/j.matdes.2025.113721

Alireza Zargaran , Timothy Alexander Listyawan , Shailendra Kumar Verma , Ji Hoon Kim , Jeremy Dudo , Changning Niu , Abhinav Saboo , Jiadong Gong , Hongseok Yang , Kyoungdoc Kim

We explore a wide compositional space of low-carbon steel, containing 11 alloying elements, assess its feasibility for fire-resistant applications via modeling yield strength at elevated temperatures. We employ the high-throughput CALPHAD-based modeling to calculate the contributions of solid solution, precipitation, and dislocation strengthening for specific compositions. Over 30,000 yield strength predictions are made at two elevated temperatures (600 °C and 700 °C) across about 5,000 unique compositions, each with three different heat treatment conditions. We analyze the big data base and optimize using the machine-learning techniques to understand the significance of different parameters on strength. Experimental validation include thermomechanical treatments, high-temperature tensile tests, and microstructural characterizations. The newly developed alloys demonstrate a yield strength of 520–770 MPa at 600 °C, more than twice the strength of the commercial S355 steel. This approach facilitates the rapid discovery of novel fire-resistant steel compositions and has a high potential for other alloy systems.

{"title":"Integrated Computational Materials Engineering of Fire-Resistant Steels","authors":"Alireza Zargaran , Timothy Alexander Listyawan , Shailendra Kumar Verma , Ji Hoon Kim , Jeremy Dudo , Changning Niu , Abhinav Saboo , Jiadong Gong , Hongseok Yang , Kyoungdoc Kim","doi":"10.1016/j.matdes.2025.113721","DOIUrl":"10.1016/j.matdes.2025.113721","url":null,"abstract":"<div><div>We explore a wide compositional space of low-carbon steel, containing 11 alloying elements, assess its feasibility for fire-resistant applications via modeling yield strength at elevated temperatures. We employ the high-throughput CALPHAD-based modeling to calculate the contributions of solid solution, precipitation, and dislocation strengthening for specific compositions. Over 30,000 yield strength predictions are made at two elevated temperatures (600 °C and 700 °C) across about 5,000 unique compositions, each with three different heat treatment conditions. We analyze the big data base and optimize using the machine-learning techniques to understand the significance of different parameters on strength. Experimental validation include thermomechanical treatments, high-temperature tensile tests, and microstructural characterizations. The newly developed alloys demonstrate a yield strength of 520–770 MPa at 600 °C, more than twice the strength of the commercial S355 steel. This approach facilitates the rapid discovery of novel fire-resistant steel compositions and has a high potential for other alloy systems.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113721"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding thermally grown complex concentrated oxides on AlCrTiVNi5 alloy for high-temperature applications

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-13 DOI: 10.1016/j.matdes.2025.113728

Haofei Sun, Meifeng Li, Xuehai Tan, Hao Zhang, Jing Liu

High-temperature (HT) applications demand the development of a slowly growing and adherent thermally grown (TG) oxide scale. The concept of complex concentrated alloys (CCAs) has been extended to oxide systems, resulting in the design of TG complex concentrated oxides (TG-CCOs). A recent advancement involved growing TG-CCOs on a new CCA, AlCrTiVNi₅, chosen from the valve metal group. In this study, our objective is to delve deeper into TG-CCOs formed on the AlCrTiVNi₅ alloy at 1000 °C. We thoroughly examined the corrosion resistance and structural stability of the CCOs under HT conditions. Results demonstrate that TG-CCOs exhibit superior thermodynamic stability, enhanced corrosion resistance in a mixed Na₂SO₄/NaCl environment at 900 °C, and significant changes in crystal structure and composition. The transition of top-layer from rock-salt to corundum phases under corrosion conditions indicates a substantial alteration through density functional theory (DFT) calculations. Moreover, lattice distortion assessments suggest that these structural changes enhance the durability of the oxides. This study underscores the potential of CCOs as protective coatings in power generation industries, offering valuable insights into the design and optimization of high-entropy oxides capable of withstanding severe environmental conditions.

{"title":"Understanding thermally grown complex concentrated oxides on AlCrTiVNi5 alloy for high-temperature applications","authors":"Haofei Sun, Meifeng Li, Xuehai Tan, Hao Zhang, Jing Liu","doi":"10.1016/j.matdes.2025.113728","DOIUrl":"10.1016/j.matdes.2025.113728","url":null,"abstract":"<div><div>High-temperature (HT) applications demand the development of a slowly growing and adherent thermally grown (TG) oxide scale. The concept of complex concentrated alloys (CCAs) has been extended to oxide systems, resulting in the design of TG complex concentrated oxides (TG-CCOs). A recent advancement involved growing TG-CCOs on a new CCA, AlCrTiVNi<sub>5</sub>, chosen from the valve metal group. In this study, our objective is to delve deeper into TG-CCOs formed on the AlCrTiVNi<sub>5</sub> alloy at 1000 °C. We thoroughly examined the corrosion resistance and structural stability of the CCOs under HT conditions. Results demonstrate that TG-CCOs exhibit superior thermodynamic stability, enhanced corrosion resistance in a mixed Na<sub>2</sub>SO<sub>4</sub>/NaCl environment at 900 °C, and significant changes in crystal structure and composition. The transition of top-layer from rock-salt to corundum phases under corrosion conditions indicates a substantial alteration through density functional theory (DFT) calculations. Moreover, lattice distortion assessments suggest that these structural changes enhance the durability of the oxides. This study underscores the potential of CCOs as protective coatings in power generation industries, offering valuable insights into the design and optimization of high-entropy oxides capable of withstanding severe environmental conditions.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113728"},"PeriodicalIF":7.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ballistic impact performance of Kevlar®/UHMWPE hybrid composite panels with a liquid thermoplastic resin, Elium®

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-12 DOI: 10.1016/j.matdes.2025.113706

Aswani Kumar Bandaru , Dinesh Kumar Kothandan , Hemant Chouhan , Hong Ma , Ronan M. O’Higgins

This study presents the ballistic impact performance of composite panels with novel liquid Methyl methacrylate (MMA) (Elium®) thermoplastic resin. The panels, which include Kevlar® (Kevlar) and ultra-high molecular weight polyethylene (UHMWPE), and hybrids with their combination (Kevlar/UHMWPE and UHMWPE/Kevlar), were manufactured with different numbers of layers (16 and 24) using vacuum-assisted resin transfer. These panels were tested against 0.38 lead round nose (300 ± 15 m/s) and 0.357 semi-jacketed soft point flat (550 ± 15 m/s) projectiles. The study assesses the ballistic impact performance of single fibre reinforced and the influence of hybridisation through various parameters such as, damage patterns, back face deformation, energy absorption, and residual velocity. The results reveal that 16 and 24 layer panels effectively defeated 0.38 projectile with relatively lower back face deformation while showing perforations for 0.357 projectile with varying residual velocities for different panel configurations. The hybrid combination of Kevlar/UHMWPE with Kevlar on the front demonstrated higher energy absorption with low residual velocity, leveraging the superior energy absorption capability of Kevlar and better stretching from UHMWPE. This study not only underscores the potential of Elium® resin-based composite panels for ballistic protection but also emphasises the crucial role of reinforcement hybridisation in enhancing the ballistic performance.

{"title":"Ballistic impact performance of Kevlar®/UHMWPE hybrid composite panels with a liquid thermoplastic resin, Elium®","authors":"Aswani Kumar Bandaru , Dinesh Kumar Kothandan , Hemant Chouhan , Hong Ma , Ronan M. O’Higgins","doi":"10.1016/j.matdes.2025.113706","DOIUrl":"10.1016/j.matdes.2025.113706","url":null,"abstract":"<div><div>This study presents the ballistic impact performance of composite panels with novel liquid Methyl methacrylate (MMA) (Elium®) thermoplastic resin. The panels, which include Kevlar<strong>®</strong> (Kevlar) and ultra-high molecular weight polyethylene (UHMWPE), and hybrids with their combination (Kevlar/UHMWPE and UHMWPE/Kevlar), were manufactured with different numbers of layers (16 and 24) using vacuum-assisted resin transfer. These panels were tested against 0.38 lead round nose (300 ± 15 m/s) and 0.357 semi-jacketed soft point flat (550 ± 15 m/s) projectiles. The study assesses the ballistic impact performance of single fibre reinforced and the influence of hybridisation through various parameters such as, damage patterns, back face deformation, energy absorption, and residual velocity. The results reveal that 16 and 24 layer panels effectively defeated 0.38 projectile with relatively lower back face deformation while showing perforations for 0.357 projectile with varying residual velocities for different panel configurations. The hybrid combination of Kevlar/UHMWPE with Kevlar on the front demonstrated higher energy absorption with low residual velocity, leveraging the superior energy absorption capability of Kevlar and better stretching from UHMWPE. This study not only underscores the potential of Elium® resin-based composite panels for ballistic protection but also emphasises the crucial role of reinforcement hybridisation in enhancing the ballistic performance.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"252 ","pages":"Article 113706"},"PeriodicalIF":7.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into structural and spectroscopic characteristics of Cu2+ doped β-Ca3(PO4)2: Correlation between Cu2+ concentration and material properties

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-12 DOI: 10.1016/j.matdes.2025.113718

Sana Elbashir , Roushdey Salh , Britt M. Andersson

Doping β-tricalcium phosphate (β-TCP) with copper (Cu²⁺) has great potential in various applications due to its rich chemistry. However, the doping characteristics are rarely studied in detail and are yet to be fully understood, creating a gap in the existing knowledge of these multifunctional materials. In this work, a series of Cu²⁺ doped β-TCP (Cu_x-TCPs) were prepared and comprehensively characterized to investigate the correlation between Cu²⁺ doping and the material properties. Also, the synthesis of Cu_x-TCPs was modeled using thermodynamic equilibrium calculations to investigate their formation pathways. The calculations predicted a possible inclusion of Cu²⁺ in intermediate phosphate phases during the material synthesis, depending on the temperature. The structural analyses revealed lattice shrinkage due to the Cu²⁺ doping and that Cu²⁺ occupied Ca4 and Ca5 sites in the β-TCP crystal. The vibrational spectroscopy of the Cu_x-TCPs showed noticeable deformation of ν₁ band of

{P O}_{4}^{3 -}

ligand. The ultraviolet–visible absorption analysis revealed a reduction in the band gap energy induced by Cu²⁺ doping. Photoluminescence spectroscopy demonstrated an enhanced emission tunability of Cu_x-TCPs in the blue and orange–red regions depending on Cu²⁺ concentration. These findings are a step toward a deeper understanding of the structure–property relationships of Cu²⁺ doped β-TCPs and can play a significant role in their multidisciplinary applications.

{"title":"New insights into structural and spectroscopic characteristics of Cu2+ doped β-Ca3(PO4)2: Correlation between Cu2+ concentration and material properties","authors":"Sana Elbashir , Roushdey Salh , Britt M. Andersson","doi":"10.1016/j.matdes.2025.113718","DOIUrl":"10.1016/j.matdes.2025.113718","url":null,"abstract":"<div><div>Doping β-tricalcium phosphate (β-TCP) with copper (Cu<sup>2+</sup>) has great potential in various applications due to its rich chemistry. However, the doping characteristics are rarely studied in detail and are yet to be fully understood, creating a gap in the existing knowledge of these multifunctional materials. In this work, a series of Cu<sup>2+</sup> doped β-TCP (Cu<sub>x</sub>-TCPs) were prepared and comprehensively characterized to investigate the correlation between Cu<sup>2+</sup> doping and the material properties. Also, the synthesis of Cu<sub>x</sub>-TCPs was modeled using thermodynamic equilibrium calculations to investigate their formation pathways. The calculations predicted a possible inclusion of Cu<sup>2+</sup> in intermediate phosphate phases during the material synthesis, depending on the temperature. The structural analyses revealed lattice shrinkage due to the Cu<sup>2+</sup> doping and that Cu<sup>2+</sup> occupied Ca4 and Ca5 sites in the β-TCP crystal. The vibrational spectroscopy of the Cu<sub>x</sub>-TCPs showed noticeable deformation of ν<sub>1</sub> band of <span><math><msubsup><mrow><mi>P</mi><mi>O</mi></mrow><mrow><mn>4</mn></mrow><mrow><mn>3</mn><mo>-</mo></mrow></msubsup></math></span> ligand. The ultraviolet–visible absorption analysis revealed a reduction in the band gap energy induced by Cu<sup>2+</sup> doping. Photoluminescence spectroscopy demonstrated an enhanced emission tunability of Cu<sub>x</sub>-TCPs in the blue and orange–red regions depending on Cu<sup>2+</sup> concentration. These findings are a step toward a deeper understanding of the structure–property relationships of Cu<sup>2+</sup> doped β-TCPs and can play a significant role in their multidisciplinary applications.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"252 ","pages":"Article 113718"},"PeriodicalIF":7.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospun poly-(L-lactide) scaffold enriched with GO-AuNPs nanocomposite stimulates skin tissue reconstruction via enhanced cell adhesion and controlled growth factors release

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-11 DOI: 10.1016/j.matdes.2025.113713

Michał Pruchniewski , Barbara Strojny-Cieślak , Paweł Nakielski , Katarzyna Zawadzka , Kaja Urbańska , Daniel Rybak , Anna Zakrzewska , Marta Grodzik , Ewa Sawosz

The disruption of homeostasis in the tissue microenvironment following skin injury necessitates the provision of a supportive niche for cells to facilitate the restoration of functional tissue. A meticulously engineered cell-scaffold biointerface is essential for eliciting the desired cellular responses that underpin therapeutic efficacy. To address this, we fabricated an electrospun poly-(L-lactide) (PLLA) cell scaffold enriched with graphene oxide (GO) and gold nanoparticles (AuNPs). Comprehensive characterization assessed the scaffolds’ microstructural, elemental, thermal, and mechanical properties. In vitro investigations evaluated the biocompatibility, adhesive and regenerative capabilities of the scaffolds utilizing human keratinocytes (HEKa), fibroblasts (HFFF2), and reconstructed epidermis (EpiDerm™) models. The results demonstrated that the incorporation of the GO-Au composite substantially altered the nanotopography and mechanical properties of the PLLA fibers. Cells effectively colonized the PLLA + GO-Au scaffold while preserving their structural morphology. Furthermore, PLLA + GO-Au treatment resulted in increased epidermal thickness and reduced tissue porosity. The scaffold exerted a significant influence on actin cytoskeleton architecture, facilitating cell adhesion through the upregulation of integrins, E-cadherin, and β-catenin. Keratinocytes exhibited enhanced secretion of growth factors (AREG, bFGF, EGF, EGF R), while fibroblast secretion remained stable. These findings endorse the scaffold’s potential for regulating cellular fate and preventing hypertrophic tissue formation in skin tissue engineering.

{"title":"Electrospun poly-(L-lactide) scaffold enriched with GO-AuNPs nanocomposite stimulates skin tissue reconstruction via enhanced cell adhesion and controlled growth factors release","authors":"Michał Pruchniewski , Barbara Strojny-Cieślak , Paweł Nakielski , Katarzyna Zawadzka , Kaja Urbańska , Daniel Rybak , Anna Zakrzewska , Marta Grodzik , Ewa Sawosz","doi":"10.1016/j.matdes.2025.113713","DOIUrl":"10.1016/j.matdes.2025.113713","url":null,"abstract":"<div><div>The disruption of homeostasis in the tissue microenvironment following skin injury necessitates the provision of a supportive niche for cells to facilitate the restoration of functional tissue. A meticulously engineered cell-scaffold biointerface is essential for eliciting the desired cellular responses that underpin therapeutic efficacy. To address this, we fabricated an electrospun poly-(L-lactide) (PLLA) cell scaffold enriched with graphene oxide (GO) and gold nanoparticles (AuNPs). Comprehensive characterization assessed the scaffolds’ microstructural, elemental, thermal, and mechanical properties. <em>In vitro</em> investigations evaluated the biocompatibility, adhesive and regenerative capabilities of the scaffolds utilizing human keratinocytes (HEKa), fibroblasts (HFFF2), and reconstructed epidermis (EpiDerm™) models. The results demonstrated that the incorporation of the GO-Au composite substantially altered the nanotopography and mechanical properties of the PLLA fibers. Cells effectively colonized the PLLA + GO-Au scaffold while preserving their structural morphology. Furthermore, PLLA + GO-Au treatment resulted in increased epidermal thickness and reduced tissue porosity. The scaffold exerted a significant influence on actin cytoskeleton architecture, facilitating cell adhesion through the upregulation of integrins, E-cadherin, and β-catenin. Keratinocytes exhibited enhanced secretion of growth factors (AREG, bFGF, EGF, EGF R), while fibroblast secretion remained stable. These findings endorse the scaffold’s potential for regulating cellular fate and preventing hypertrophic tissue formation in skin tissue engineering.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113713"},"PeriodicalIF":7.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-throughput framework for pile-up correction in high-speed nanoindentation maps

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-11 DOI: 10.1016/j.matdes.2025.113708

Edoardo Rossi , Daniele Duranti , Saqib Rashid , Michal Zitek , Rostislav Daniel , Marco Sebastiani

Accurate mapping of mechanical properties across extensive areas in heterogeneous materials is essential for understanding phase-specific contributions to strength and hardness. High-speed nanoindentation mapping enables their x-y spatial mapping through a fast and dense grid of indents. However, accurate measurements are complicated by pile-up, the plastic displacement of material laterally and vertically around an indent, causing hardness and modulus overestimation, especially in materials with varying phase compliance. Traditional correction methods rely on time-consuming, localized Atomic Force Microscopy measurements, which are impractical for large-area mapping. This study presents a fast and semi-automated solution using High-speed nanoindentation mapping-induced surface roughness changes S_a, quantifiable by optical profilometry, with machine learning to correct pile-up over extensive areas selectively. By correlating these roughness changes with the Atomic Force Microscopy-measured pile-up height, we derived universal calibration functions for a wide range of bulk materials and thin films, validated through Finite Element Modeling. Applied to a benchmark cobalt-based, chromium-tungsten alloy, the method uses unsupervised clustering to identify piling-up phases in the cobalt matrix while excluding the hard carbides. This approach reduced the hardness and modulus errors by up to 7 %, uniquely enabling accurate phase-specific property mapping in high-speed nanoindentation, advancing the mechanical microscopy frontier.

{"title":"A high-throughput framework for pile-up correction in high-speed nanoindentation maps","authors":"Edoardo Rossi , Daniele Duranti , Saqib Rashid , Michal Zitek , Rostislav Daniel , Marco Sebastiani","doi":"10.1016/j.matdes.2025.113708","DOIUrl":"10.1016/j.matdes.2025.113708","url":null,"abstract":"<div><div>Accurate mapping of mechanical properties across extensive areas in heterogeneous materials is essential for understanding phase-specific contributions to strength and hardness. High-speed nanoindentation mapping enables their x-y spatial mapping through a fast and dense grid of indents. However, accurate measurements are complicated by pile-up, the plastic displacement of material laterally and vertically around an indent, causing hardness and modulus overestimation, especially in materials with varying phase compliance. Traditional correction methods rely on time-consuming, localized Atomic Force Microscopy measurements, which are impractical for large-area mapping. This study presents a fast and semi-automated solution using High-speed nanoindentation mapping-induced surface roughness changes <em>S</em><sub><em>a</em></sub>, quantifiable by optical profilometry, with machine learning to correct pile-up over extensive areas selectively. By correlating these roughness changes with the Atomic Force Microscopy-measured pile-up height, we derived universal calibration functions for a wide range of bulk materials and thin films, validated through Finite Element Modeling. Applied to a benchmark cobalt-based, chromium-tungsten alloy, the method uses unsupervised clustering to identify piling-up phases in the cobalt matrix while excluding the hard carbides. This approach reduced the hardness and modulus errors by up to 7 %, uniquely enabling accurate phase-specific property mapping in high-speed nanoindentation, advancing the mechanical microscopy frontier.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113708"},"PeriodicalIF":7.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-02-11 DOI: 10.1016/j.matdes.2025.113714

Hao Zeng, Qinghong Lai, Wuqiang Liao, Jiajin Tu, Junfeng Sun

Macrophage aggregation and excessive inflammation are prevalent issues in diabetic wounds, often resulting in impaired wound healing. Consequently, hydrogel dressings with immunomodulatory properties hold significant potential for clinical application in the management of diabetic wound healing. Nonetheless, existing immunomodulatory hydrogels typically necessitate intricate interventions and costly treatments. The researchers developed a novel gallic acid (GA) hybrid hydrogel with built-in immunomodulatory capabilities to speed up the healing of diabetic wounds. This hybrid hydrogel matrix was synthesized using a porcine acellular dermal matrix (Padm) and incorporated novel bioactive glass nanoparticles (MBG) doped with cerium (Ce) and GA. The integration of these components preserved the natural structure of the Padm while imparting it with immunomodulatory capabilities. In vitro experiments demonstrated the favorable biocompatibility and robust immunomodulatory capabilities of the GA-Padm@Ce hybrid hydrogel. The immunomodulatory properties suggest that the GA-Padm@Ce hybrid hydrogel can be utilized for safe and effective treatment, facilitating the acceleration of the three stages of wound healing. Thus, it is expected to become an optimal dressing for diabetic wound treatment.

{"title":"Hybrid hydrogel based on porcine-derived matrix with gallic acid and cerium-doped mesoporous bioactive glass for diabetic wound healing","authors":"Hao Zeng, Qinghong Lai, Wuqiang Liao, Jiajin Tu, Junfeng Sun","doi":"10.1016/j.matdes.2025.113714","DOIUrl":"10.1016/j.matdes.2025.113714","url":null,"abstract":"<div><div>Macrophage aggregation and excessive inflammation are prevalent issues in diabetic wounds, often resulting in impaired wound healing. Consequently, hydrogel dressings with immunomodulatory properties hold significant potential for clinical application in the management of diabetic wound healing. Nonetheless, existing immunomodulatory hydrogels typically necessitate intricate interventions and costly treatments. The researchers developed a novel gallic acid (GA) hybrid hydrogel with built-in immunomodulatory capabilities to speed up the healing of diabetic wounds. This hybrid hydrogel matrix was synthesized using a porcine acellular dermal matrix (Padm) and incorporated novel bioactive glass nanoparticles (MBG) doped with cerium (Ce) and GA. The integration of these components preserved the natural structure of the Padm while imparting it with immunomodulatory capabilities. <em>In vitro</em> experiments demonstrated the favorable biocompatibility and robust immunomodulatory capabilities of the GA-Padm@Ce hybrid hydrogel. The immunomodulatory properties suggest that the GA-Padm@Ce hybrid hydrogel can be utilized for safe and effective treatment, facilitating the acceleration of the three stages of wound healing. Thus, it is expected to become an optimal dressing for diabetic wound treatment.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"251 ","pages":"Article 113714"},"PeriodicalIF":7.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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