Lung cancer is the most leading cause of cancer death. Traditional chemotherapy has unavoidable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. Nanocarriers can achieve accurate delivery and reduce adverse reactions of drugs, which have received extensive attention. In this work, hollow manganese dioxide (HMnO2) nanoparticle (NP) that is highly responsive to tumor microenvironment, was simultaneously loaded with paclitaxel (PTX), a chemotherapy drug, and imiquimod (R837), a toll-like receptor 7 agonist. Those NPs were then coated with bacterial outer-membrane vesicles (OMVs-HMnO2@PTX + R837 NPs), whose surface proteins could act as tumor-specific antigens. The obtained nanovaccine inherited superior tumor-targeting capacity of OMVs and promoted retention in tumors. As a result, intravenous injection of the nanovaccine led to remarkable tumor growth inhibition. Furthermore, we found that the nanovaccine effectively boosted dendritic cells maturation and increased cytotoxic T lymphocytes infiltration. Taken together, these results demonstrated the great potential in applying OMVs-enveloped nano-activator in cancer chemo-immunotherapy.
{"title":"Dual-drug loaded manganese dioxide nanoparticles coated with bacterial outer-membrane vesicles for chemo-immunotherapy in lung cancer","authors":"Lixu Xie , Shichang Jiang , Changwen Zhang , Miao Liu , Yiqing Qu","doi":"10.1016/j.matdes.2024.113406","DOIUrl":"10.1016/j.matdes.2024.113406","url":null,"abstract":"<div><div>Lung cancer is the most leading cause of cancer death. Traditional chemotherapy has unavoidable drawbacks of nonspecific tumor targeting, high toxicity, and poor therapeutic efficiency. Nanocarriers can achieve accurate delivery and reduce adverse reactions of drugs, which have received extensive attention. In this work, hollow manganese dioxide (HMnO<sub>2</sub>) nanoparticle (NP) that is highly responsive to tumor microenvironment, was simultaneously loaded with paclitaxel (PTX), a chemotherapy drug, and imiquimod (R837), a toll-like receptor 7 agonist. Those NPs were then coated with bacterial outer-membrane vesicles (OMVs-HMnO<sub>2</sub>@PTX + R837 NPs), whose surface proteins could act as tumor-specific antigens. The obtained nanovaccine inherited superior tumor-targeting capacity of OMVs and promoted retention in tumors. As a result, intravenous injection of the nanovaccine led to remarkable tumor growth inhibition. Furthermore, we found that the nanovaccine effectively boosted dendritic cells maturation and increased cytotoxic T lymphocytes infiltration. Taken together, these results demonstrated the great potential in applying OMVs-enveloped nano-activator in cancer chemo-immunotherapy.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113406"},"PeriodicalIF":7.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-22DOI: 10.1016/j.matdes.2024.113401
Tiphaine Giroud, Patrick Villechaise, Azdine Naït-Ali, David Mellier, Samuel Hémery
High strength metastable β titanium alloys are widely employed in the aircraft industry due to their outstanding strength-to-weight ratio. While components can endure complex in-service mechanical loading, the anisotropy in tensile properties has been the subject of limited attention. In this study, its origin was investigated focusing on the role played by millimeter scale β grains as they were recently identified as a source of heterogeneous deformation. Tensile properties of Ti-10V-2Fe-3Al processed via different thermomechanical routes were assessed using multiple sampling directions. In particular, elongation values were observed to vary significantly depending on the testing direction. A combination of SEM, EBSD, µ-CT and in-situ DIC during tensile tests was employed to clarify the underlying causes of this behavior. Substantial differences in strain heterogeneity and localization were found related to features of β grains, including their crystallographic and morphologic orientations. Furthermore, multiple fracture mechanisms were observed to derive from the differences in deformation behavior, and eventually compete to trigger specimen failure. Elongation values are then determined by both the degree of strain heterogeneity and the operating fracture mechanisms. These findings provide a new understanding of the role of the microstructure in the tensile behavior of high strength metastable β titanium alloys.
{"title":"Anisotropy in tensile properties of a high strength metastable β titanium alloy","authors":"Tiphaine Giroud, Patrick Villechaise, Azdine Naït-Ali, David Mellier, Samuel Hémery","doi":"10.1016/j.matdes.2024.113401","DOIUrl":"10.1016/j.matdes.2024.113401","url":null,"abstract":"<div><div>High strength metastable β titanium alloys are widely employed in the aircraft industry due to their outstanding strength-to-weight ratio. While components can endure complex in-service mechanical loading, the anisotropy in tensile properties has been the subject of limited attention. In this study, its origin was investigated focusing on the role played by millimeter scale β grains as they were recently identified as a source of heterogeneous deformation. Tensile properties of Ti-10V-2Fe-3Al processed via different thermomechanical routes were assessed using multiple sampling directions. In particular, elongation values were observed to vary significantly depending on the testing direction. A combination of SEM, EBSD, µ-CT and in-situ DIC during tensile tests was employed to clarify the underlying causes of this behavior. Substantial differences in strain heterogeneity and localization were found related to features of β grains, including their crystallographic and morphologic orientations. Furthermore, multiple fracture mechanisms were observed to derive from the differences in deformation behavior, and eventually compete to trigger specimen failure. Elongation values are then determined by both the degree of strain heterogeneity and the operating fracture mechanisms. These findings provide a new understanding of the role of the microstructure in the tensile behavior of high strength metastable β titanium alloys.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113401"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-22DOI: 10.1016/j.matdes.2024.113399
Gaia de Marzo , Luca Fachechi , Valentina Antonaci , Vincenzo Mariano Mastronardi , Luigi Portaluri , Maria Teresa Todaro , Luciana Algieri , Antonio Qualtieri , Francesco Rizzi , Michele Scaraggi , Massimo De Vittorio
Thanks to their intrinsic flexibility, energy efficiency and high portability, soft piezoelectric thin films represent the most effective technological approach for wearable devices to monitor health conditions. In order to improve effectiveness and applicability, more and more innovative and high-performing soft piezoelectric materials are being developed and benchmarked through their piezoelectric d33 coefficient. However, most existing methods to measure the d33 were developed for ceramic or bulk materials and cannot be applied to soft materials because high force/pressure can deform and damage the material structure. This work introduces a simple, effective, and fast method to accurately measure the d33 of soft and thin piezoelectric films by applying weak sinusoidal forces to avoid any damage to the sample, and simultaneously measuring the charges produced by the direct piezoelectric effect. The approach is versatile as it can be used for different types of materials and sizes of the active area. This method represents an effective solution to speed up the process of material optimization, paving the way for the rapid development of novel wearable piezoelectric devices.
{"title":"On the measurement of piezoelectric d33 coefficient of soft thin films under weak mechanical loads: A rapid and affordable method","authors":"Gaia de Marzo , Luca Fachechi , Valentina Antonaci , Vincenzo Mariano Mastronardi , Luigi Portaluri , Maria Teresa Todaro , Luciana Algieri , Antonio Qualtieri , Francesco Rizzi , Michele Scaraggi , Massimo De Vittorio","doi":"10.1016/j.matdes.2024.113399","DOIUrl":"10.1016/j.matdes.2024.113399","url":null,"abstract":"<div><div>Thanks to their intrinsic flexibility, energy efficiency and high portability, soft piezoelectric thin films represent the most effective technological approach for wearable devices to monitor health conditions. In order to improve effectiveness and applicability, more and more innovative and high-performing soft piezoelectric materials are being developed and benchmarked through their piezoelectric d<sub>33</sub> coefficient. However, most existing methods to measure the d<sub>33</sub> were developed for ceramic or bulk materials and cannot be applied to soft materials because high force/pressure can deform and damage the material structure. This work introduces a simple, effective, and fast method to accurately measure the d<sub>33</sub> of soft and thin piezoelectric films by applying weak sinusoidal forces to avoid any damage to the sample, and simultaneously measuring the charges produced by the direct piezoelectric effect. The approach is versatile as it can be used for different types of materials and sizes of the active area. This method represents an effective solution to speed up the process of material optimization, paving the way for the rapid development of novel wearable piezoelectric devices.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113399"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-22DOI: 10.1016/j.matdes.2024.113391
Raj Pradip Khawale , Greg Vinal , Rahul Rai , William W. Menasco , Gary F. Dargush
Advancements in additive manufacturing enable the development of artificial lattice structures with unique properties not found in natural materials. Specifically, filament-based lattices are known for having a lightweight yet strong nature, exhibiting auxetic behavior and excellent energy absorption capabilities. Recent research has focused on developing algorithms and frameworks to manipulate cell geometry and material properties to achieve unusual properties. However, the exploration of the full design space is hampered in practice primarily due to restrictions on cell tiling variation. Here, for the first time, a Tiling-Based Lattice Generation (TBLatGen) framework is presented that relies on various tiling operations and stochastic changes in internal cell geometry. By utilizing reflections, rotations, glide reflections, translations, and combinations of these operations, lattice structures are tiled to achieve an extensive range of properties. For instance, achieving Poisson's ratios ranging over at least ±20 using a minimal set of design parameters is demonstrated, a range unprecedented in prior studies. Experimental testing of a physical prototype validates the auxetic behavior of one newly proposed tiled lattice structure. Beyond this, the proposed TBLatGen framework is anticipated to be applicable to general periodic metamaterials, enabling the design and discovery of new structures exhibiting exceptional mechanical, thermal, electrical, or magnetic properties.
{"title":"Tiling-based lattice generation for structural property exploration","authors":"Raj Pradip Khawale , Greg Vinal , Rahul Rai , William W. Menasco , Gary F. Dargush","doi":"10.1016/j.matdes.2024.113391","DOIUrl":"10.1016/j.matdes.2024.113391","url":null,"abstract":"<div><div>Advancements in additive manufacturing enable the development of artificial lattice structures with unique properties not found in natural materials. Specifically, filament-based lattices are known for having a lightweight yet strong nature, exhibiting auxetic behavior and excellent energy absorption capabilities. Recent research has focused on developing algorithms and frameworks to manipulate cell geometry and material properties to achieve unusual properties. However, the exploration of the full design space is hampered in practice primarily due to restrictions on cell tiling variation. Here, for the first time, a Tiling-Based Lattice Generation (TBLatGen) framework is presented that relies on various tiling operations and stochastic changes in internal cell geometry. By utilizing reflections, rotations, glide reflections, translations, and combinations of these operations, lattice structures are tiled to achieve an extensive range of properties. For instance, achieving Poisson's ratios ranging over at least ±20 using a minimal set of design parameters is demonstrated, a range unprecedented in prior studies. Experimental testing of a physical prototype validates the auxetic behavior of one newly proposed tiled lattice structure. Beyond this, the proposed TBLatGen framework is anticipated to be applicable to general periodic metamaterials, enabling the design and discovery of new structures exhibiting exceptional mechanical, thermal, electrical, or magnetic properties.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113391"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-22DOI: 10.1016/j.matdes.2024.113396
Jože Luzar , Andreja Jelen , Juraj Nálepka , Saeid Salari , Primož Koželj , Stanislav Vrtnik , Peter Mihor , Julia Petrović , Magdalena Wencka , Goran Dražić , Anton Meden , Pavol Priputen , Janez Dolinšek
Searching for high-entropy alloys with functional properties that emerge from their multi-scale structure, we have investigated the (GaNi)xCoCrFe (x = 0.4–1.6) system. We have characterized structure, microstructure, nanostructure and chemical composition of the individual phases in the multi-phase alloys and determined their magnetic, magnetostrictive and electrical properties. We found that the alloys are ferromagnetic and exhibit functional combination of magnetic softness and vanishing magnetostriction, classifying them as energy-efficient “supersilent” materials (inaudible to a human ear) for alternating-current (AC) electromagnetic applications in the audio-frequency range. The alloys develop a two-phase structure, a face-centered cubic (fcc) and a body-centered cubic (bcc), where the fcc phase fraction decreases, while the bcc fraction increases with the increasing (GaNi)x content. Ferromagnetism of the alloys originates from the highly nanostructured bcc phase, with the ferromagnetic Curie temperatures in the range = 750–700 K, depending on x. The fcc phase is not nanostructured and is paramagnetic at room temperature, but undergoes a spin glass transition at K. The magnetic softness and vanishing magnetostriction of the alloys are both nanomagnetic phenomena. The magnetic-softness and magnetostriction parameters of the x = 1.3 and 1.6 alloys make them relevant for supersilent AC applications at low frequencies.
{"title":"Nanostructure-induced functional combination of vanishing magnetostriction and magnetic softness in ferromagnetic (GaNi)xCoCrFe (x = 0.4–1.6) high-entropy alloys","authors":"Jože Luzar , Andreja Jelen , Juraj Nálepka , Saeid Salari , Primož Koželj , Stanislav Vrtnik , Peter Mihor , Julia Petrović , Magdalena Wencka , Goran Dražić , Anton Meden , Pavol Priputen , Janez Dolinšek","doi":"10.1016/j.matdes.2024.113396","DOIUrl":"10.1016/j.matdes.2024.113396","url":null,"abstract":"<div><div>Searching for high-entropy alloys with functional properties that emerge from their multi-scale structure, we have investigated the (GaNi)<em><sub>x</sub></em>CoCrFe (<em>x</em> = 0.4–1.6) system. We have characterized structure, microstructure, nanostructure and chemical composition of the individual phases in the multi-phase alloys and determined their magnetic, magnetostrictive and electrical properties. We found that the alloys are ferromagnetic and exhibit functional combination of magnetic softness and vanishing magnetostriction, classifying them as energy-efficient “supersilent” materials (inaudible to a human ear) for alternating-current (AC) electromagnetic applications in the audio-frequency range. The alloys develop a two-phase structure, a face-centered cubic (fcc) and a body-centered cubic (bcc), where the fcc phase fraction decreases, while the bcc fraction increases with the increasing (GaNi)<em><sub>x</sub></em> content. Ferromagnetism of the alloys originates from the highly nanostructured bcc phase, with the ferromagnetic Curie temperatures in the range <span><math><msub><mi>T</mi><mi>C</mi></msub></math></span> = 750–700 K, depending on <em>x</em>. The fcc phase is not nanostructured and is paramagnetic at room temperature, but undergoes a spin glass transition at <span><math><mrow><msub><mi>T</mi><mi>f</mi></msub><mo>≈</mo><mn>6.4</mn></mrow></math></span> K. The magnetic softness and vanishing magnetostriction of the alloys are both nanomagnetic phenomena. The magnetic-softness and magnetostriction parameters of the <em>x</em> = 1.3 and 1.6 alloys make them relevant for supersilent AC applications at low frequencies.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113396"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-22DOI: 10.1016/j.matdes.2024.113388
Nicholas Derimow , Jake T. Benzing , Howie Joress , Austin McDannald , Ping Lu , Frank W. DelRio , Newell Moser , Matthew J. Connolly , Alec I. Saville , Orion L. Kafka , Chad Beamer , Ryan Fishel , Suchismita Sarker , Chris Hadley , Nik Hrabe
This work investigated non-standard HIP cycles for PBF-L Ti-6Al-4V and characterized microstructure and tensile properties to compare between material that originated from the same build. For 920 °C, faster cooling rates (100 °C/min, 2000 °C/min) were found to promote bi-lamellar α microstructure, while the 2000 °C/min cooling rate improved the strength. For HIP with lower temperature (800 °C, 200 MPa), coarsening was minimized resulting in strength improvement. The slow cooling rate (12 °C/min) showed the highest strength as faster rates increased the amount of orthorhombic martensite (). For HIP with higher temperature (1050 °C), the as-built crystallographic texture was reduced and equiaxed prior-β grain morphology resulted, leading to more isotropic tensile properties. However, the cooling rate (2000 °C/min) was not enough to prevent formation of grain boundary α, which reduced strength and elongation. Machine learning was carried out on the dataset via Principal Component Analysis (PCA) to reduce the dimensionality of the parameters and microstructural features.
{"title":"Microstructure and mechanical properties of laser powder bed fusion Ti-6Al-4V after HIP treatments with varied temperatures and cooling rates","authors":"Nicholas Derimow , Jake T. Benzing , Howie Joress , Austin McDannald , Ping Lu , Frank W. DelRio , Newell Moser , Matthew J. Connolly , Alec I. Saville , Orion L. Kafka , Chad Beamer , Ryan Fishel , Suchismita Sarker , Chris Hadley , Nik Hrabe","doi":"10.1016/j.matdes.2024.113388","DOIUrl":"10.1016/j.matdes.2024.113388","url":null,"abstract":"<div><div>This work investigated non-standard HIP cycles for PBF-L Ti-6Al-4V and characterized microstructure and tensile properties to compare between material that originated from the same build. For 920<!--> <!-->°C, faster cooling rates (100<!--> <!-->°C/min, 2000<!--> <!-->°C/min) were found to promote bi-lamellar α microstructure, while the 2000<!--> <!-->°C/min cooling rate improved the strength. For HIP with lower temperature (800<!--> <!-->°C, 200 MPa), coarsening was minimized resulting in strength improvement. The slow cooling rate (12<!--> <!-->°C/min) showed the highest strength as faster rates increased the amount of orthorhombic martensite (<span><math><msup><mrow><mi>α</mi></mrow><mrow><mo>″</mo></mrow></msup></math></span>). For HIP with higher temperature (1050<!--> <!-->°C), the as-built crystallographic texture was reduced and equiaxed prior-β grain morphology resulted, leading to more isotropic tensile properties. However, the cooling rate (2000<!--> <!-->°C/min) was not enough to prevent formation of grain boundary α, which reduced strength and elongation. Machine learning was carried out on the dataset via Principal Component Analysis (PCA) to reduce the dimensionality of the parameters and microstructural features.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113388"},"PeriodicalIF":7.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-21DOI: 10.1016/j.matdes.2024.113387
Massimiliano Casata, Sergio Perosanz, Conrado Garrido, Daniel Barba
Laser powder bed fusion (LPBF) enables geometrical designs of great complexity, such as metamaterials. These structures are founded on elemental struts printed at various orientations and sizes. Understanding how these design variables affect mechanical properties is crucial for optimizing component performance. This work aims to systematically investigate the impact between these design variables on defects, roughness, geometrical deviations, and microstructure of Ti-6Al-4V elemental struts and correlate them with mechanical properties. The analysis shows that smaller strut diameters present an increased sensitivity to defects, reducing ductility by 45.8% on average as the diameter decreases from 1.5 mm to 0.5 mm. When compared to vertical struts, horizontally printed struts of 1.5 mm, 1 mm, and 0.5 mm present on average a respective reduction in ductility of 57.4%, 59.8%, and 70.9%, and a respective reduction in the ultimate strength of 13.3%, 24.5%, 61.2%. This has been associated with warping and increased roughness caused by dross formation. Finally, the study shows the complex interaction of process parameters' effect with the struts' orientation and size. These findings pose the basis for a more accurate and optimal mechanical design of cellular metamaterials, from the underlying material perspective.
{"title":"A holistic study of the effect of geometrical and processing conditions on the static mechanical performance of LPBF strut elements","authors":"Massimiliano Casata, Sergio Perosanz, Conrado Garrido, Daniel Barba","doi":"10.1016/j.matdes.2024.113387","DOIUrl":"10.1016/j.matdes.2024.113387","url":null,"abstract":"<div><div>Laser powder bed fusion (LPBF) enables geometrical designs of great complexity, such as metamaterials. These structures are founded on elemental struts printed at various orientations and sizes. Understanding how these design variables affect mechanical properties is crucial for optimizing component performance. This work aims to systematically investigate the impact between these design variables on defects, roughness, geometrical deviations, and microstructure of Ti-6Al-4V elemental struts and correlate them with mechanical properties. The analysis shows that smaller strut diameters present an increased sensitivity to defects, reducing ductility by 45.8% on average as the diameter decreases from 1.5 mm to 0.5 mm. When compared to vertical struts, horizontally printed struts of 1.5 mm, 1 mm, and 0.5 mm present on average a respective reduction in ductility of 57.4%, 59.8%, and 70.9%, and a respective reduction in the ultimate strength of 13.3%, 24.5%, 61.2%. This has been associated with warping and increased roughness caused by dross formation. Finally, the study shows the complex interaction of process parameters' effect with the struts' orientation and size. These findings pose the basis for a more accurate and optimal mechanical design of cellular metamaterials, from the underlying material perspective.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113387"},"PeriodicalIF":7.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-21DOI: 10.1016/j.matdes.2024.113395
Francesc Canalejo-Codina , Mariola Cano-Morenilla , Jordi Martorell , Mercedes Balcells , Marta Pegueroles , Andrés A. García-Granada
Polymer-based bioresorbable scaffolds (BRS) aim to reduce the long-term issues associated with metal stents. Yet, first-generation BRS designs experienced a significantly higher rate of clinical failures compared to permanent implants. This prompted the development of alternative scaffolds, such as the poly(L-lactide-co-ε-caprolactone) (PLCL) solvent-casted stent, whose mechanical performance has yet to be addressed. This study examines the mechanical behavior of this novel scaffold across a wide range of parallel and radial compression diameters. The analysis highlights the scaffold’s varying responses under different loading conditions and provides insights into interpreting simulation model parameters to accurately reflect experimental results.
Stents demonstrated a parallel crush resistance of 0.11 N/mm at maximum compression, whereas the radial forces were significantly higher, reaching up to 1.80 N/mm. Additionally, the parallel test keeps the stent in the elastic regime, with almost no regions exceeding 50 MPa of stress, while the radial test causes significant structural deformation, with localized plastic strain reaching up to 30 %. Results showed that underestimating yield strain in computational models leads to discrepancies with experimental results, being 5 % the most accurate value for matching computational and experimental results for PLCL solvent-casted stents.
This comprehensive approach is vital for optimizing BRS design and predicting clinical performance.
{"title":"3D printed polymeric stent design: Mechanical testing and computational modeling","authors":"Francesc Canalejo-Codina , Mariola Cano-Morenilla , Jordi Martorell , Mercedes Balcells , Marta Pegueroles , Andrés A. García-Granada","doi":"10.1016/j.matdes.2024.113395","DOIUrl":"10.1016/j.matdes.2024.113395","url":null,"abstract":"<div><div>Polymer-based bioresorbable scaffolds (BRS) aim to reduce the long-term issues associated with metal stents. Yet, first-generation BRS designs experienced a significantly higher rate of clinical failures compared to permanent implants. This prompted the development of alternative scaffolds, such as the poly(L-lactide-co-ε-caprolactone) (PLCL) solvent-casted stent, whose mechanical performance has yet to be addressed. This study examines the mechanical behavior of this novel scaffold across a wide range of parallel and radial compression diameters. The analysis highlights the scaffold’s varying responses under different loading conditions and provides insights into interpreting simulation model parameters to accurately reflect experimental results.</div><div>Stents demonstrated a parallel crush resistance of 0.11 N/mm at maximum compression, whereas the radial forces were significantly higher, reaching up to 1.80 N/mm. Additionally, the parallel test keeps the stent in the elastic regime, with almost no regions exceeding 50 MPa of stress, while the radial test causes significant structural deformation, with localized plastic strain reaching up to 30 %. Results showed that underestimating yield strain in computational models leads to discrepancies with experimental results, being 5 % the most accurate value for matching computational and experimental results for PLCL solvent-casted stents.</div><div>This comprehensive approach is vital for optimizing BRS design and predicting clinical performance.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113395"},"PeriodicalIF":7.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-20DOI: 10.1016/j.matdes.2024.113393
Xiangyang Peng , Peipei Cao , Di Liu , Congcong Li , Zhaohui Lu , Shuo Hou , Jianming Zhou , Guangyao Lu , Engang Fu , Suihe Jiang , Zhaoping Lu
Recently, a new anti-irradiation mechanism relying on reversible disorder-ordering transition of coherent nanoparticles was discovered, which significantly improves the microstructural stability and void swelling resistance of metallic materials. However, the factors that govern the outstanding stability and superb radiation tolerance are still not clear. Here, two kinds of FeCrAl alloys were designed, each strengthened by a different type of coherent phase: L21-ordered Fe2AlV and B2-ordered Ni (Al, Fe). It was observed that the two alloys exhibited disparate responses to high-dose ion irradiations at elevated temperatures. The L21-Fe2AlV precipitates were found to be completely dissolved after 50 dpa of ion irradiation at 500–600 °C, whereas the B2-NiAl precipitates remained stability even after 200 dpa irradiation. This research challenges the conventional wisdom that the stability of nanoparticles is governed by the balance between radiation-enhanced coarsening and radiation dissolution. Instead, it demonstrates the re-nucleation and subsequent interface-controlled solute reshuffling processes govern the stability of coherent chemically-ordered nanoparticles under radiation at high temperatures. We demonstrate that the low interfacial energy, which is related to both the simply chemically-ordered lattice structure and low lattice misfit interface, is crucial for enabling such short-range elemental reshuffling process to repeatedly form nanoprecipitates that cannot be suppressed by radiation.
{"title":"On the origin of superior stability of coherent nanoparticles under ion irradiation","authors":"Xiangyang Peng , Peipei Cao , Di Liu , Congcong Li , Zhaohui Lu , Shuo Hou , Jianming Zhou , Guangyao Lu , Engang Fu , Suihe Jiang , Zhaoping Lu","doi":"10.1016/j.matdes.2024.113393","DOIUrl":"10.1016/j.matdes.2024.113393","url":null,"abstract":"<div><div>Recently, a new anti-irradiation mechanism relying on reversible disorder-ordering transition of coherent nanoparticles was discovered, which significantly improves the microstructural stability and void swelling resistance of metallic materials. However, the factors that govern the outstanding stability and superb radiation tolerance are still not clear. Here, two kinds of FeCrAl alloys were designed, each strengthened by a different type of coherent phase: L2<sub>1</sub>-ordered Fe2AlV and B2-ordered Ni (Al, Fe). It was observed that the two alloys exhibited disparate responses to high-dose ion irradiations at elevated temperatures. The L2<sub>1</sub>-Fe2AlV precipitates were found to be completely dissolved after 50 dpa of ion irradiation at 500–600 °C, whereas the B2-NiAl precipitates remained stability even after 200 dpa irradiation. This research challenges the conventional wisdom that the stability of nanoparticles is governed by the balance between radiation-enhanced coarsening and radiation dissolution. Instead, it demonstrates the re-nucleation and subsequent interface-controlled solute reshuffling processes govern the stability of coherent chemically-ordered nanoparticles under radiation at high temperatures. We demonstrate that the low interfacial energy, which is related to both the simply chemically-ordered lattice structure and low lattice misfit interface, is crucial for enabling such short-range elemental reshuffling process to repeatedly form nanoprecipitates that cannot be suppressed by radiation.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113393"},"PeriodicalIF":7.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sporopollenin exine capsules (SECs), extracted from plant pollen grains, are becoming increasingly popular as natural microcapsules for a broad spectrum of bio-composite applications due to their plentiful supply, resilience to chemicals and physical stress, unique species-specific designs, exceptional consistency in structure, and significant internal volume. However, SECs have a relatively bioinert interface hindering their application in biomaterials. Thus, surface modification is an efficient strategy to convert SECs into biocompatible materials better for biological applications. Previous approaches predominantly depend on labor-intensive, multi-stage procedures that are time-consuming. Herein, we report an ultrafast, one-step, and effective modification strategy to render SECs biocompatibility by coating them with ferric ions and tannic acids, which endow them with a better cell adhesion property. In summary, our results show that this ultrafast and one-step biocompatibility strategy enhances the functional characteristics of SECs and holds wide-ranging implications for bio-composite applications.
{"title":"Ultrafast and one-step coating sporopollenin exine capsules with metal-phenolic networks for bio-composite applications","authors":"Sheng Zhou , Dengxian Wu , Guanjie Zhou , Qing Jiang , Zhihong Xu","doi":"10.1016/j.matdes.2024.113390","DOIUrl":"10.1016/j.matdes.2024.113390","url":null,"abstract":"<div><div>Sporopollenin exine capsules (SECs), extracted from plant pollen grains, are becoming increasingly popular as natural microcapsules for a broad spectrum of bio-composite applications due to their plentiful supply, resilience to chemicals and physical stress, unique species-specific designs, exceptional consistency in structure, and significant internal volume. However, SECs have a relatively bioinert interface hindering their application in biomaterials. Thus, surface modification is an efficient strategy to convert SECs into biocompatible materials better for biological applications. Previous approaches predominantly depend on labor-intensive, multi-stage procedures that are time-consuming. Herein, we report an ultrafast, one-step, and effective modification strategy to render SECs biocompatibility by coating them with ferric ions and tannic acids, which endow them with a better cell adhesion property. In summary, our results show that this ultrafast and one-step biocompatibility strategy enhances the functional characteristics of SECs and holds wide-ranging implications for bio-composite applications.</div><div>.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"247 ","pages":"Article 113390"},"PeriodicalIF":7.6,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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