Materials & Design最新文献

英文中文

Millimeter-wave 3D printing metasurface filtering crossover based on a single groove gap waveguide cavity

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-31 DOI: 10.1016/j.matdes.2025.113904

Hongtao Gu , Jinxuan Ni , Xin Zhou , Jingyi Zhang , Gang Zhang , Jiquan Yang

A millimeter-wave (mm-wave) 3D-printing metasurface filtering crossover based on groove gap waveguide (GGW) structure is proposed in this letter. Firstly, the metasurface composed of electromagnetic bandgap elements in GGW technology is designed and analyzed. This configuration effectively mitigates radiation and electromagnetic wave leakage. The upper part of the GGW resonator features a groove structure with periodic pins distributed, while the lower part consists of a metal groove structure. Subsequently, by incorporating resonant irises, the device order and bandwidth are increased. Transmission zeros (TZ) is generated by cross-coupling between the GGW resonator and source. Furthermore, by adding an L-shaped capacitive stub at one end of each port, another TZ is created, further enhancing the frequency selectivity of the filtering crossover. To verify the design, a third-order filtering crossover operating in the Ka band is fabricated using 3D printing technology. The measured results show excellent agreement with the simulations. The final filtering crossover achieves a 3-dB fractional bandwidth of 4.8 %, a return loss better than 19.5 dB, and an in-band isolation greater than 32 dB.

{"title":"Millimeter-wave 3D printing metasurface filtering crossover based on a single groove gap waveguide cavity","authors":"Hongtao Gu , Jinxuan Ni , Xin Zhou , Jingyi Zhang , Gang Zhang , Jiquan Yang","doi":"10.1016/j.matdes.2025.113904","DOIUrl":"10.1016/j.matdes.2025.113904","url":null,"abstract":"<div><div>A millimeter-wave (mm-wave) 3D-printing metasurface filtering crossover based on groove gap waveguide (GGW) structure is proposed in this letter. Firstly, the metasurface composed of electromagnetic bandgap elements in GGW technology is designed and analyzed. This configuration effectively mitigates radiation and electromagnetic wave leakage. The upper part of the GGW resonator features a groove structure with periodic pins distributed, while the lower part consists of a metal groove structure. Subsequently, by incorporating resonant irises, the device order and bandwidth are increased. Transmission zeros (TZ) is generated by cross-coupling between the GGW resonator and source. Furthermore, by adding an <em>L</em>-shaped capacitive stub at one end of each port, another TZ is created, further enhancing the frequency selectivity of the filtering crossover. To verify the design, a third-order filtering crossover operating in the <em>Ka</em> band is fabricated using 3D printing technology. The measured results show excellent agreement with the simulations. The final filtering crossover achieves a 3-dB fractional bandwidth of 4.8 %, a return loss better than 19.5 dB, and an in-band isolation greater than 32 dB.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113904"},"PeriodicalIF":7.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electronic density of states as the descriptor of elastic bond strength, ductility, and local lattice distortion in BCC refractory alloys

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-30 DOI: 10.1016/j.matdes.2025.113885

Dharmendra Pant, Dilpuneet S. Aidhy

Although electronic density of states (DOS) is fundamental to materials properties, its general relationship to mechanical properties of alloys is not well established. In this paper, using density functional theory (DFT) calculations, we show that the electronic occupancy at the Fermi level, N(E_f), obtained from DOS is a key descriptor of alloy strength and ductility. Our comprehensive analysis of numerous body centered cubic (BCC) refractory high entropy alloys (RHEAs) shows an overwhelming correlation that low N(E_f) indicates strong bonds that have high stiffness resulting in high elastic constants. High bond stiffness indicates presence of covalent nature of bonds that are directional in nature resulting in resistance to deformation leading to high bulk (B) and shear (G) moduli. Consequently, N(E_f) provides a direct correlation to the tendency of alloy ductility evidenced in the Pugh ratio (G/B). As stiffer bonds result in lower local lattice distortion (LLD), N(E_f) are LLD are also found to be corelated which opens up a correlation to solid solution strengthening and yield strength. Thus, this work unveils fundamental correlations between N(E_f) and (1) elastic bond strength, (2) ductility, and (3) LLD. These correlations open opportunities for the design of high strength high ductile RHEAs.

{"title":"Electronic density of states as the descriptor of elastic bond strength, ductility, and local lattice distortion in BCC refractory alloys","authors":"Dharmendra Pant, Dilpuneet S. Aidhy","doi":"10.1016/j.matdes.2025.113885","DOIUrl":"10.1016/j.matdes.2025.113885","url":null,"abstract":"<div><div>Although electronic density of states (DOS) is fundamental to materials properties, its general relationship to mechanical properties of alloys is not well established. In this paper, using density functional theory (DFT) calculations, we show that the electronic occupancy at the Fermi level, N(<em>E<sub>f</sub></em>), obtained from DOS is a key descriptor of alloy strength and ductility. Our comprehensive analysis of numerous body centered cubic (BCC) refractory high entropy alloys (RHEAs) shows an overwhelming correlation that low N(<em>E<sub>f</sub></em>) indicates strong bonds that have high stiffness resulting in high elastic constants. High bond stiffness indicates presence of covalent nature of bonds that are directional in nature resulting in resistance to deformation leading to high bulk (<em>B</em>) and shear (<em>G</em>) moduli. Consequently, N(<em>E<sub>f</sub></em>) provides a direct correlation to the tendency of alloy ductility evidenced in the Pugh ratio (<em>G</em>/<em>B</em>). As stiffer bonds result in lower local lattice distortion (LLD), N(<em>E<sub>f</sub></em>) are LLD are also found to be corelated which opens up a correlation to solid solution strengthening and yield strength. Thus, this work unveils fundamental correlations between N(<em>E<sub>f</sub></em>) and (1) elastic bond strength, (2) ductility, and (3) LLD. These correlations open opportunities for the design of high strength high ductile RHEAs.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113885"},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microenvironment-responsive multi-enzyme cascade nanosystem for the treatment of early caries

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-30 DOI: 10.1016/j.matdes.2025.113890

Haowen Huang , Yu Wang , Xin Liu , Wanqiu Xue , Ruoxi Dai , Chris Ying Cao

Oral diseases associated with dental biofilms have become one of the frontiers in clinical research due to their complexity. Dental caries is a typical biofilm driven disease resulting from the diet and microbiota-matrix interactions, and it remains a substantial clinical challenge to halt the progression of caries and simultaneously repair the damaged enamel. In this regard, an oral microenvironment-responsive strategy was put forward to develop a multi-enzyme cascade nanosystem possessing antibacterial and in situ mineralization properties. During application in the oral cavity, starch was hydrolyzed by α-amylase, thereby releasing calcium phosphate prenucleation clusters (CaP-PNCs) for in situ remineralization of demineralized enamel, and providing the hydrolysis product glucose. Subsequently, glucose oxidase (GOD) conjugated to dextran-coated iron oxide nanozyme (Dex-IONP-GOD, DIG) catalyzed the production of H₂O₂ from glucose. Under the acidic caries microenvironment, IONP with POD-like activity can trigger H₂O₂ to generate reactive oxygen species. This process exhibited bactericidal activities and effectively inhibited the adhesion and biofilm formation of Streptococcus mutans. This bifunctional multi-enzyme cascade nanosystem accomplishes the adaptive initiation of pathogen elimination and in situ mineralization by its environmental responsiveness, rather than relying on the exogenous substrates, which thus provides a potential strategy for preventing and treating dental caries.

{"title":"Microenvironment-responsive multi-enzyme cascade nanosystem for the treatment of early caries","authors":"Haowen Huang , Yu Wang , Xin Liu , Wanqiu Xue , Ruoxi Dai , Chris Ying Cao","doi":"10.1016/j.matdes.2025.113890","DOIUrl":"10.1016/j.matdes.2025.113890","url":null,"abstract":"<div><div>Oral diseases associated with dental biofilms have become one of the frontiers in clinical research due to their complexity. Dental caries is a typical biofilm driven disease resulting from the diet and microbiota-matrix interactions, and it remains a substantial clinical challenge to halt the progression of caries and simultaneously repair the damaged enamel. In this regard, an oral microenvironment-responsive strategy was put forward to develop a multi-enzyme cascade nanosystem possessing antibacterial and <em>in situ</em> mineralization properties. During application in the oral cavity, starch was hydrolyzed by α-amylase, thereby releasing calcium phosphate prenucleation clusters (CaP-PNCs) for <em>in situ</em> remineralization of demineralized enamel, and providing the hydrolysis product glucose. Subsequently, glucose oxidase (GOD) conjugated to dextran-coated iron oxide nanozyme (Dex-IONP-GOD, DIG) catalyzed the production of H<sub>2</sub>O<sub>2</sub> from glucose. Under the acidic caries microenvironment, IONP with POD-like activity can trigger H<sub>2</sub>O<sub>2</sub> to generate reactive oxygen species. This process exhibited bactericidal activities and effectively inhibited the adhesion and biofilm formation of <em>Streptococcus mutans</em>. This bifunctional multi-enzyme cascade nanosystem accomplishes the adaptive initiation of pathogen elimination and <em>in situ</em> mineralization by its environmental responsiveness, rather than relying on the exogenous substrates, which thus provides a potential strategy for preventing and treating dental caries.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113890"},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multispectral metasurface for visible transparency, infrared stealth, and mm-Wave frequency-multiplexing

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-30 DOI: 10.1016/j.matdes.2025.113903

Jiahao Ge , Yifeng Wang , Yaqiang Zhang , Chang Long , Xiong Wang , Cheng Zhang , Hongxing Dong , Long Zhang

Metasurfaces have shown remarkable capabilities in tailoring the electromagnetic wavefronts at a subwavelength scale. However, existing metasurfaces that operate at a customized frequency still face significant challenges in satisfying the demands of multi-mode surveillance technologies and integrated systems. Here, we propose a concept of multispectral metasurface that can achieve the compatibility of visible, infrared, and millimeter-wave frequency regions, thereby not only expanding the degree of freedom in manipulating electromagnetic fields, but also facilitating the development of modern optoelectronic devices requiring miniaturization and integration. The proposed metasurface consists of two sets of meta-atoms arranged in an interleaved configuration, enabling independent 3-bit phase modulation at two distinct millimeter-wave frequencies. Proof-of-concept experiments demonstrate the implementation of a frequency-selective bifocal metalens and a dual-channel meta-hologram using the proposed design, both of which exhibit high visible transparency and low infrared emissivity simultaneously. This work provides a new paradigm for multispectral-compatible metasurfaces with boosted information capacity for various application scenarios, including optical windows, high-gain lens antennas, and wireless communication systems requiring multi-channel signal processing.

{"title":"Multispectral metasurface for visible transparency, infrared stealth, and mm-Wave frequency-multiplexing","authors":"Jiahao Ge , Yifeng Wang , Yaqiang Zhang , Chang Long , Xiong Wang , Cheng Zhang , Hongxing Dong , Long Zhang","doi":"10.1016/j.matdes.2025.113903","DOIUrl":"10.1016/j.matdes.2025.113903","url":null,"abstract":"<div><div>Metasurfaces have shown remarkable capabilities in tailoring the electromagnetic wavefronts at a subwavelength scale. However, existing metasurfaces that operate at a customized frequency still face significant challenges in satisfying the demands of multi-mode surveillance technologies and integrated systems. Here, we propose a concept of multispectral metasurface that can achieve the compatibility of visible, infrared, and millimeter-wave frequency regions, thereby not only expanding the degree of freedom in manipulating electromagnetic fields, but also facilitating the development of modern optoelectronic devices requiring miniaturization and integration. The proposed metasurface consists of two sets of meta-atoms arranged in an interleaved configuration, enabling independent 3-bit phase modulation at two distinct millimeter-wave frequencies. Proof-of-concept experiments demonstrate the implementation of a frequency-selective bifocal metalens and a dual-channel meta-hologram using the proposed design, both of which exhibit high visible transparency and low infrared emissivity simultaneously. This work provides a new paradigm for multispectral-compatible metasurfaces with boosted information capacity for various application scenarios, including optical windows, high-gain lens antennas, and wireless communication systems requiring multi-channel signal processing.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113903"},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile and straightforward fabrication of antimicrobial Cu-Ce oxide nanoagent for repair of acutely infected wounds

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-29 DOI: 10.1016/j.matdes.2025.113901

Jinhui Lin , Zhaowei Wang , Jiangshan Hu , Tingting Li , Liang Chen , Xiaoyun Hu , Xiaolong Liu , Qiang Luo , Peiyuan Wang

The infection of multidrug-resistant bacteria makes chronic wounds difficult to heal, so there is a great need for new treatment strategies that can eradicate bacteria and promote wound healing. The antibacterial strategy based on reactive oxygen species (ROS) has opened new avenues to overcome the enormous challenges of antibiotic research, such as the lack of broad-spectrum antibiotics and the emergence of super resistant bacteria. In this study, we have successfully prepared a Cu-Ce co-doped nanometal oxide antimicrobial nanoagent using a straightforward and efficient hydrothermal strategy. It facilitates the healing of wounds induced by bacterial infections. The antibacterial mechanism of Cu-Ce nanoparticles involves their firm attachment to the bacterial cell wall, leading to its rupture and the subsequent production of ROS. Furthermore, treatment with Cu-Ce nanoagent reduces bacterial counts in mouse skin, stimulates collagen deposition, and expedites the recovery of bacterially infected wounds. Our study presents a straightforward and effective approach for addressing wound infections and promoting healing.

{"title":"Facile and straightforward fabrication of antimicrobial Cu-Ce oxide nanoagent for repair of acutely infected wounds","authors":"Jinhui Lin , Zhaowei Wang , Jiangshan Hu , Tingting Li , Liang Chen , Xiaoyun Hu , Xiaolong Liu , Qiang Luo , Peiyuan Wang","doi":"10.1016/j.matdes.2025.113901","DOIUrl":"10.1016/j.matdes.2025.113901","url":null,"abstract":"<div><div>The infection of multidrug-resistant bacteria makes chronic wounds difficult to heal, so there is a great need for new treatment strategies that can eradicate bacteria and promote wound healing. The antibacterial strategy based on reactive oxygen species (ROS) has opened new avenues to overcome the enormous challenges of antibiotic research, such as the lack of broad-spectrum antibiotics and the emergence of super resistant bacteria. In this study, we have successfully prepared a Cu-Ce co-doped nanometal oxide antimicrobial nanoagent using a straightforward and efficient hydrothermal strategy. It facilitates the healing of wounds induced by bacterial infections. The antibacterial mechanism of Cu-Ce nanoparticles involves their firm attachment to the bacterial cell wall, leading to its rupture and the subsequent production of ROS. Furthermore, treatment with Cu-Ce nanoagent reduces bacterial counts in mouse skin, stimulates collagen deposition, and expedites the recovery of bacterially infected wounds. Our study presents a straightforward and effective approach for addressing wound infections and promoting healing.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113901"},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explainable machine learning and feature engineering applied to nanoindentation data

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-29 DOI: 10.1016/j.matdes.2025.113897

C.O.W. Trost , S. Žák , S. Schaffer , L. Walch , J. Zitz , T. Klünsner , H. Leitner , L. Exl , M.J. Cordill

The work aims to challenge the hegemony in the literature of clustering nanoindentation data solely relying on elastic modulus and hardness as features, thereby discarding information provided by the full load–displacement curve. Features based on dimensional analysis initially aimed to solve the inverse nanoindentation problem were adopted to describe the load–displacement curves. More than 3000 indents in high-speed steels were labelled via imaging after indenting. The resulting dataset was used to train and benchmark supervised (classification) and unsupervised (clustering) machine learning models, showing that feature engineering was more impactful than model selection and hyperparameter tuning, increasing the prediction quality in all studied models. The best classifier’s predictions were explained via a game theory-based approach, allowing insights into the model’s decision-making process and connecting the fields of materials property clustering and materials mechanics.

引用次数: 0

Exploration for the physical origin and impact of chemical short-range order in high-entropy alloys: Machine learning-assisted study

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-29 DOI: 10.1016/j.matdes.2025.113892

Panhua Shi , Zhen Xie , Jiaxuan Si , Jianqiao Yu , Xiaoyong Wu , Yaojun Li , Qiu Xu , Yuexia Wang

Atomic-level chemical short-range order (CSRO) in high-entropy alloys (HEAs) has ever garnered increasing attention. However, the mechanisms underlying the effects of CSRO remain poorly understood. Material informatics, through a machine learning (ML) algorithm, can fit the high-dimensional correlation between features well and provide an approach for elucidating complex mechanisms. In this study, we introduced a set of interpretable ML workflows and determined the best algorithm (kernel ridge regression (KRR)) for predicting the atomic stress in HEAs, which can deepen the understanding of the formation mechanism of CSRO. Based on first-principles calculations and Monte Carlo methods, we obtained information on each atom at the atomic and electronic levels to establish the ML features. By systematically studying these features, we found that Shapley additive algorithm indicated that t_2g orbitals are fundamental factors that dominate atomic stress, which is critical in the CSRO landscape. Additionally, we discovered that the elemental t_2g-e_g orbital relationship in FeCoNiTi system greatly influences the characteristics of atomic coordination. Moreover, the closely packed configuration efficiently promotes the ideal strength of the short-range order (SRO) HEA compared to its fully random counterpart. We posit that this endeavor provides a theoretical bedrock for grappling with experimental quandaries and theoretical conundrums.

{"title":"Exploration for the physical origin and impact of chemical short-range order in high-entropy alloys: Machine learning-assisted study","authors":"Panhua Shi , Zhen Xie , Jiaxuan Si , Jianqiao Yu , Xiaoyong Wu , Yaojun Li , Qiu Xu , Yuexia Wang","doi":"10.1016/j.matdes.2025.113892","DOIUrl":"10.1016/j.matdes.2025.113892","url":null,"abstract":"<div><div>Atomic-level chemical short-range order (CSRO) in high-entropy alloys (HEAs) has ever garnered increasing attention. However, the mechanisms underlying the effects of CSRO remain poorly understood. Material informatics, through a machine learning (ML) algorithm, can fit the high-dimensional correlation between features well and provide an approach for elucidating complex mechanisms. In this study, we introduced a set of interpretable ML workflows and determined the best algorithm (kernel ridge regression (KRR)) for predicting the atomic stress in HEAs, which can deepen the understanding of the formation mechanism of CSRO. Based on first-principles calculations and Monte Carlo methods, we obtained information on each atom at the atomic and electronic levels to establish the ML features. By systematically studying these features, we found that Shapley additive algorithm indicated that <em>t<sub>2g</sub></em> orbitals are fundamental factors that dominate atomic stress, which is critical in the CSRO landscape. Additionally, we discovered that the elemental <em>t<sub>2g</sub>-e<sub>g</sub></em> orbital relationship in FeCoNiTi system greatly influences the characteristics of atomic coordination. Moreover, the closely packed configuration efficiently promotes the ideal strength of the short-range order (SRO) HEA compared to its fully random counterpart. We posit that this endeavor provides a theoretical bedrock for grappling with experimental quandaries and theoretical conundrums.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113892"},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-28 DOI: 10.1016/j.matdes.2025.113883

L. He, Z. Javid Anbardan, P. Habibovic, S. van Rijt

Elevating oxidative stress presents a promising osteosarcoma (OS) treatment strategy, as it can selectively induce cell death in OS cells. Selenium nanoparticles (SeNPs) and doxorubicin (Dox) have shown promise in this regard by effectively upregulating oxidative stress. However, limitations, such as nanoparticle aggregation, inefficient intracellular uptake, and high-dose toxicity, hinder their therapeutic potential. Stimuli-responsive release can address these issues by enhancing effectiveness and minimizing side effects. In this paper, stimuli-responsive release of SeNPs/Dox for enhanced OS therapy is investigated. The introduction of a mesoporous silica coating (MS) onto SeNPs (SeMS) was used to prevent aggregation and allow for Dox co-encapsulation. The MS surface was further functionalized with hyaluronic acid (HA) using disulfide bonds (to create SeMS_Dox-SS-HA), to function as a gatekeeper and to enable pH- and redox-responsive release. Our results demonstrate low pH and elevated GSH levels can activate SeMS_Dox-SS-HA, resulting in rapid Dox/Se release within OS cells. Moreover, SeMS_Dox-SS-HA show significantly heightened OS inhibition, attributed to the differential reactive oxygen species (ROS) production and glutathione (GSH) depletion within OS cells, while hMSCs remained unaffected. These findings suggest that this pH/GSH-responsive MS delivery system encapsulating SeNPs and Dox represents a promising nanoplatform for OS-selective therapy through redox modulation.

{"title":"pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment","authors":"L. He, Z. Javid Anbardan, P. Habibovic, S. van Rijt","doi":"10.1016/j.matdes.2025.113883","DOIUrl":"10.1016/j.matdes.2025.113883","url":null,"abstract":"<div><div>Elevating oxidative stress presents a promising osteosarcoma (OS) treatment strategy, as it can selectively induce cell death in OS cells. Selenium nanoparticles (SeNPs) and doxorubicin (Dox) have shown promise in this regard by effectively upregulating oxidative stress. However, limitations, such as nanoparticle aggregation, inefficient intracellular uptake, and high-dose toxicity, hinder their therapeutic potential. Stimuli-responsive release can address these issues by enhancing effectiveness and minimizing side effects. In this paper, stimuli-responsive release of SeNPs/Dox for enhanced OS therapy is investigated. The introduction of a mesoporous silica coating (MS) onto SeNPs (SeMS) was used to prevent aggregation and allow for Dox co-encapsulation. The MS surface was further functionalized with hyaluronic acid (HA) using disulfide bonds (to create SeMS<sub>Dox</sub>-SS-HA), to function as a gatekeeper and to enable pH- and redox-responsive release. Our results demonstrate low pH and elevated GSH levels can activate SeMS<sub>Dox</sub>-SS-HA, resulting in rapid Dox/Se release within OS cells. Moreover, SeMS<sub>Dox</sub>-SS-HA show significantly heightened OS inhibition, attributed to the differential reactive oxygen species (ROS) production and glutathione (GSH) depletion within OS cells, while hMSCs remained unaffected. These findings suggest that this pH/GSH-responsive MS delivery system encapsulating SeNPs and Dox represents a promising nanoplatform for OS-selective therapy through redox modulation.</div></div>","PeriodicalId":383,"journal":{"name":"Materials & Design","volume":"253 ","pages":"Article 113883"},"PeriodicalIF":7.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143759882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bandgap formation and tuning in gyroid lattice structures: Simulations and experiments

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-28 DOI: 10.1016/j.matdes.2025.113896

Mohammad Shaaban , Sami El-Borgi , Aravind Krishnamoorthy

This study provides a comprehensive investigation of the mechanical bandgap characteristics of gyroid lattice structures. Two methods are used to predict the bandgaps. The first examines wave dispersion in a single unit cell to identify bandgaps through dispersion curves. The second employs harmonic analysis on a finite structure to calculate its steady-state response and plot the frequency response function (FRF). To validate the numerical predictions, PLA matrix and network gyroids samples are manufactured using Fused Deposition Modeling (FDM) and tested for vibration attenuation. The network gyroid demonstrated superior bandgap performance compared to the matrix gyroid, with the broadest bandgap spanning between 6.61 kHz and 7.74 kHz. Parametric studies revealed that the wall thickness, unit cell size, and material properties significantly influence the location and bandwidth of bandgaps, enabling their precise tuning. These findings highlight the potential of the network gyroid structures for vibration-sensitive engineering applications.

引用次数: 0

Immunomodulatory exosomes loaded chitosan methacryloyl hydrogel combined with pro-chondrogenic microspheres for promoting articular cartilage regeneration

IF 7.6 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2025-03-28 DOI: 10.1016/j.matdes.2025.113876

Ruoyu Liang , Zhaoxu Li , Qu Xu , Shengtao Wang , Dongxu Chen , Peng Gui , Mingzhou Chen , Wei Peng , Jian Su

A diverse range of biological materials has been widely used for the management of injuries to joint cartilage. However, suboptimal outcomes in cartilage repair are often due to inappropriate host immune responses and inadequate microenvironments for chondrogenesis. Therefore, there is a need to develop innovative hydrogel systems with immunomodulatory capabilities that promote a favorable environment for cartilage regeneration. In this study, we fabricated a Chitosan Methacryloyl (CSMA) hydrogel and incorporated exosomes derived from lipopolysaccharide (LPS)-activated NR8383 macrophages stimulated with Epigallocatechin gallate (EGCG) (EGCG-exo). Additionally, Kartogenin (KGN)-incorporated poly (lactic-co-glycolic acid) (PLGA) microspheres (KGN μS) were added to the hydrogel to stimulate chondrogenic differentiation of recruited BMSCs upon KGN release. The immunomodulatory and pro-chondrogenic properties of the CSMA-EGCG-exo@KGN μS microsphere-gel system were evaluated both in vitro and in vivo. The CSMA-EGCG-exo@KGN μS system not only demonstrated macrophage reprogramming properties but also enhanced BMSC recruitment and promoted chondrogenesis, leading to improved cartilage regeneration in a rabbit model of cartilage lesions. Looking forward, the CSMA-EGCG-exo@KGN μS microsphere-gel system holds significant potential for clinical translation as a pro-regenerative implant material for the treatment of cartilage injuries.

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