Materials & Design最新文献_第4页

Research on energetic demolition micro device for rapid fire rescue 用于快速火灾救援的高能爆破微型装置研究

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-14 DOI: 10.1016/j.matdes.2026.115496

Hengzhen Feng , Wenxing Kan , Wenzhong Lou , Dongjie Liao , Yi Lu , Jie Ren , Chuan Xiao

During fire scenarios, establishing emergency escape routes rapidly inside buildings is the primary factor in improving fire survival rates, with fast and efficient demolition of windows acting as a critical technical measure. A shaped demolition device that integrates an energetic micro-trigger (based on an initiator—copper azide—titanium flyer) with the CL-20 energetic material is proposed. First, a blast pressure-strength matching model is established between the energetic materials and the materials to be demolished. Analysis indicated that a φ3 mm × 3 mm CL-20 generates a pressure of up to 35 GPa on tempered glass and thus realizes complete fragmentation of 10-mm-thick tempered glass within 600 μs. Second, the study establishes a theoretical model of the flyer velocity in the time domain, demonstrating an error of less than 7 % between the theoretical and experimental values of the flyer’s peak speed. Finally, in the demolition system, under 20 V/33 μF electrical stimulation, a φ1 mm × 1 mm copper azide can drive a titanium flyer of 40 ∼ 80 μm to detonate the CL-20 reliably and shatter 15-mm-thick tempered glass completely. The energetic micro-demolition device proposed in this study enables rapid, reliable destruction of high-strength window materials to create emergency escape routes. It improve trapped victims’ survival probability significantly in fire scenarios, thus demonstrating strong practical applicability.

在火灾情况下，在建筑物内迅速建立紧急逃生通道是提高火灾存活率的首要因素，快速有效地拆除窗户是一项关键的技术措施。提出了一种将含能微触发器（基于叠氮化铜飞片）与CL-20含能材料相结合的成形爆破装置。首先，建立了含能材料与待拆除材料的爆破压力-强度匹配模型；分析表明，φ 3mm × 3mm CL-20对钢化玻璃产生高达35gpa的压力，可在600 μs内实现10mm厚钢化玻璃的完全破碎。其次，建立了飞片速度的时域理论模型，证明了飞片峰值速度的理论值与实验值的误差小于7%。最后，在爆破系统中，在20 V/33 μF的电刺激下，φ1 mm × 1 mm叠氮化铜可以驱动40 ~ 80 μm的钛飞片可靠地引爆CL-20，并将15 mm厚的钢化玻璃完全粉碎。本研究提出的高能微爆破装置能够快速、可靠地破坏高强度窗户材料，创造紧急逃生通道。显著提高了火灾场景下被困人员的生存概率，具有较强的实用性。

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引用次数: 0

Effect of high-frequency beam oscillation on the microstructure and mechanical properties of deep-penetration vacuum laser-welded Inconel 718 joints 高频光束振荡对深熔真空激光焊接Inconel 718接头组织和力学性能的影响

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115488

Meng Jiang , Lijun Yang , Xi Chen , Yumo Jiang , Shengkui Zhang , Xinyu Cui , Jinzhu Wang , Chengyang He , Peng He , Yanbin Chen

When a deep-penetration weld was fabricated by high-energy beam welding, the microstructure and mechanical heterogeneities along the depth direction frequently occurred, which had an adverse effect on the serviceability of the deep-penetration welded nickel-based superalloy components. To address this issue, this study introduces a high-frequency beam oscillation strategy to actively homogenize the microstructure and properties of Inconel 718 joints with depth of penetration exceeding 21 mm fabricated by vacuum laser beam welding. Results demonstrated that oscillation significantly refined the Laves phase. With the increase of oscillating frequency, the content of Laves phase decreased from 6.28 % to 4.07 %, the fraction of large Laves particles (>3.0 µm) decreased from 9.82 % to below 6.4 % and the secondary dendrite arm spacing was reduced from 4.71 µm to under 3.85 µm. This refinement is attributed to Nb element homogenization, which hinders Laves phase formation, and the physically limited growth space within refined secondary dendrite arm spacing. The weld joint with high-frequency beam oscillation showed a more uniform tensile strength with a coefficient of variation of 1.15 % and an average strength of approximately 850.8 MPa. This work provides a novel pathway to tailor the microstructure and mechanical performance for single-pass deep-penetration welding of thick 718 components.

高能束焊接制备深熔焊缝时，经常出现沿深度方向的显微组织和力学不均匀性，对镍基高温合金深熔件的使用性能产生不利影响。为了解决这一问题，本研究引入了高频光束振荡策略，对真空激光束焊接中熔深超过21 mm的Inconel 718接头的组织和性能进行了主动均匀化。结果表明，振荡显著地细化了Laves相。随着振荡频率的增加，Laves相的含量从6.28%减少到4.07%，大Laves颗粒（>3.0µm）的含量从9.82%减少到6.4%以下，二次枝晶臂间距从4.71µm减少到3.85µm以下。这种细化是由于Nb元素的均匀化阻碍了Laves相的形成，并且在细化的二次枝晶臂间距内物理限制了生长空间。高频梁振荡焊接接头的抗拉强度变化系数为1.15%，平均强度约为850.8 MPa。该工作为厚718件单道次深熔焊接的微观组织和力学性能定制提供了新的途径。

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引用次数: 0

Achieving superior tensile and fatigue properties than conventional wrought state via hybrid additive-forging manufacturing 通过混合增材锻造制造，获得了优于传统锻造状态的拉伸和疲劳性能

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115485

Wei Wang , Zinong Tan , Yaping Wang , Ruiqiang Zhang , Jianglin Huang , Jintana Patawee , Michael Allen , Katie Meredith , Jianguo Lin , Christopher Hopper , Jun Jiang

Additively manufactured materials typically contain undesired defects and microstructures. These defects reduce material performance and limit the adoption of the technique in production environments. In this work, we report a hybrid manufacturing strategy that integrates additive manufacturing with hot forging to achieve exceptional mechanical properties in Ti-6Al-4V. The resulting material exhibits improved tensile and fatigue properties compared to its purely additively manufactured and conventionally wrought counterparts. The control of thermal history and plastic flow is capable of healing defects and tailoring microstructure. A series of combined forging and heat treatment processes were undertaken to reveal correlations between fabrication parameters and the resulting microstructures and mechanical response. The underlying mechanisms of microstructure evolution were investigated through systematic and integrated experimental characterization, finite element modelling and mechanical tests. A generic component, representative of an aero-engine blade, was fabricated using this technology, demonstrating the huge promise of adopting this technique in practical applications.

增材制造的材料通常含有不想要的缺陷和微结构。这些缺陷降低了材料性能，限制了该技术在生产环境中的应用。在这项工作中，我们报告了一种混合制造策略，该策略将增材制造与热锻相结合，以实现Ti-6Al-4V的卓越机械性能。与纯增材制造和传统锻造的材料相比，所得到的材料具有更好的拉伸和疲劳性能。热历史和塑性流动的控制能够修复缺陷和定制微观结构。进行了一系列锻造和热处理相结合的工艺，以揭示制造参数与产生的显微组织和力学响应之间的相关性。通过系统和综合的实验表征、有限元建模和力学试验，研究了微观结构演变的潜在机制。一个通用部件，航空发动机叶片的代表，是用这种技术制造的，证明了在实际应用中采用这种技术的巨大前景。

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引用次数: 0

Quantum chemical insights into molecular interactions within asphalt systems 沥青系统中分子相互作用的量子化学见解

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115489

Guannan Li , Mengyuan He , Changjiang Dai , Liang He , Tianling Wang , Xin Liu

Molecular aggregation significantly impacts the stability, rheology, and durability of asphalt binders. While previous research has mainly focused on asphaltenes, the quantum-scale mechanisms of aggregation for all asphalt components remain unclear. This study uses quantum chemical calculations on 50 asphalt molecules to analyze surface electrostatic potential, π-electron properties, LOLIPOP index, and weak interaction energies to identify favorable aggregation configurations. The findings reveal that π-π interactions drive asphaltene aggregation, resins act as modifiers, aromatics enhance solubility and dispersibility, and saturated hydrocarbons create steric hindrance. Additionally, the length of polycyclic aromatic hydrocarbons and alkyl chains play a critical role in determining intermolecular distance and polarity. SARA fractionation and^1H NMR analysis of four binders show that TH asphalt, rich in π-electron-dense components with long side chains, stabilizes the microstructure, resulting in optimal rheological properties. AFM imaging reveals a honeycomb structure primarily formed by asphaltene-driven aggregation. In summary, this computational-experimental framework elucidates the molecular origins of asphalt aggregation and the distinct roles of SARA components, establishes a clear composition-performance relationship, and provides mechanistic guidance for designing durable asphalt.

分子聚集显著影响沥青粘合剂的稳定性、流变性和耐久性。虽然以前的研究主要集中在沥青质上，但所有沥青组分的量子尺度聚集机制仍不清楚。本研究采用量子化学计算方法对50个沥青分子进行表面静电势、π电子性质、LOLIPOP指数和弱相互作用能分析，以确定有利的聚集构型。研究结果表明，π-π相互作用驱动沥青质聚集，树脂作为改性剂，芳烃增强溶解度和分散性，饱和烃产生空间位阻。此外，多环芳烃和烷基链的长度对分子间距离和极性起关键作用。四种粘结剂的SARA分馏和^1H NMR分析表明，TH沥青富含长侧链π电子密组分，稳定了其微观结构，具有最佳的流变性能。原子力显微镜成像显示蜂窝状结构主要由沥青质驱动的聚集形成。总之，这一计算-实验框架阐明了沥青聚集的分子起源和SARA组分的独特作用，建立了明确的成分-性能关系，并为设计耐用沥青提供了机制指导。

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引用次数: 0

Processing and performance of HVAF-sprayed Fe-based bulk metallic glass coatings: A sustainable alternative 高温流化床喷涂铁基大块金属玻璃涂层的工艺和性能：一种可持续的替代方案

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115480

Rahul Jude Alroy , Stefan Björklund , David Linder , Savya Sachi , Vasanth Gopal , František Lukáč , Edouard Mignot , Radek Mušálek , Shrikant Joshi

Bulk metallic glasses (BMGs) are increasingly recognized as promising materials for surface engineering due to their exceptional hardness, corrosion resistance, and wear resistance, which are critical attributes for components operating in harsh environments. Fe-based BMGs offer a sustainable alternative to conventional coatings that often rely on toxic or scarce raw materials, thus aligning with global environmental and regulatory objectives. This study focuses on a newly developed Fe-based BMG alloy with enhanced glass-forming ability and processability for thermal spray applications. While BMGs exhibit outstanding properties, their limited ductility poses significant processing challenges, including propensity to cracking during deposition. To overcome this, the feasibility of producing dense Fe-based BMG coatings using High Velocity Air Fuel (HVAF) spraying was examined, aiming for superior wear and corrosion resistance. Initial trials resulted in coatings with severe cracking, delamination, and poor adhesion. However, systematic manipulation of spray parameters led to coatings with markedly reduced cracking, improved adhesion, and enhanced microstructural integrity. Comprehensive characterization included microstructure, amorphicity, and hardness examination, complemented by wear and corrosion performance assessments. The promising results represent a critical step toward establishing Fe-based BMGs as viable and environmentally friendly coating solutions via HVAF thermal spraying.

大块金属玻璃（bmg）由于其优异的硬度、耐腐蚀性和耐磨性，越来越被认为是表面工程中有前途的材料，这些都是在恶劣环境中工作的部件的关键属性。铁基bmg为依赖有毒或稀缺原材料的传统涂料提供了一种可持续的替代方案，从而符合全球环境和监管目标。本文研究了一种新开发的铁基BMG合金，该合金具有增强的玻璃形成能力和可加工性，可用于热喷涂应用。虽然bmg具有出色的性能，但其有限的延展性带来了重大的加工挑战，包括在沉积过程中容易开裂。为了克服这一问题，研究了利用高速空气燃料（HVAF）喷涂制备致密铁基BMG涂层的可行性，旨在获得优异的耐磨损和耐腐蚀性能。最初的试验导致涂层严重开裂、分层和附着力差。然而，系统地控制喷涂参数导致涂层明显减少开裂，改善附着力，增强微观结构的完整性。综合表征包括微观结构、非晶性和硬度检查，并辅以磨损和腐蚀性能评估。这些有希望的结果表明，通过HVAF热喷涂，将铁基bmg作为可行的环保涂层解决方案迈出了关键的一步。

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引用次数: 0

Interrupted in-situ X-ray computed tomography reveals accelerated densification in recovered 7055 Al powder 中断原位x射线计算机断层扫描显示在回收的7055 Al粉末中加速致密化

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115484

Maocao Le , Mengzhen Li , Kesong Miao , Hao Wu , Gongqi Shi , Rengeng Li , Guohua Fan

Efficient recovery of aluminum alloy powder represents a critical challenge in powder metallurgy, particularly given that irregular morphology and broad particle size distribution in recovered powders induce complex sintering behaviors not yet fully understood. In this study, in-situ X-ray computed tomography was employed to systematically investigate the densification mechanisms of commercial gas-atomized and spray-forming-recovered 7055 aluminum powders during hot-press sintering. Results demonstrate that despite 10.6% lower initial packing density, recovered powder exhibits ∼50% faster peak densification rate and order-of-magnitude higher total effective diffusivity. Three-dimensional pore analysis confirms a classical “cup-saddle-cap” evolution pathway in both systems, but recovered powder initiates pore rupture 25°C earlier, accelerates spheroidization, primarily attributable to irregular particle geometry and packing heterogeneity. Laplace stress mapping further reveals sustained local stress concentrations (>1.5 MPa) at neck regions, promoting asymmetric neck growth and multi-neck interconnection, which collectively accelerate pore closure and overall densification. This work establishes a direct microstructure-property linkage between particle morphology, stress fields, and densification kinetics, providing fundamental insights for the high-value utilization of recovered aluminum powders.

有效回收铝合金粉末是粉末冶金领域的一个关键挑战，特别是考虑到回收的粉末中不规则的形貌和广泛的粒度分布导致复杂的烧结行为尚未完全了解。在本研究中，采用原位x射线计算机断层扫描技术系统地研究了商用气体雾化和喷雾成形回收的7055铝粉在热压烧结过程中的致密化机制。结果表明，尽管初始堆积密度降低了10.6%，但回收粉末的峰值致密率提高了约50%，总有效扩散系数提高了一个数量级。三维孔隙分析证实了这两种体系的经典“杯-鞍-帽”演化路径，但回收粉末导致孔隙破裂的时间提前了25°C，加速了球化，主要原因是颗粒几何形状不规则和堆积不均一性。拉普拉斯应力映射进一步揭示了颈部区域持续的局部应力集中（>1.5 MPa），促进了颈部不对称生长和多颈部互连，共同加速了孔隙闭合和整体致密化。这项工作建立了颗粒形态、应力场和致密化动力学之间的直接微观结构-性能联系，为回收铝粉的高价值利用提供了基础见解。

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引用次数: 0

Thermal path dependence of secondary carbide precipitation kinetics and morphology in high-Cr cast irons 高铬铸铁中二次碳化物析出动力学和形貌的热径依赖性

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115483

M.A. Guitar, U.P. Nayak, F. Mücklich

High-chromium cast irons (HCCIs) are optimized for wear resistance through controlled heat-treatments. A 26 wt% Cr HCCI was investigated by varying the heating rate (1 or 10 °C/min), cooling mode (water-quenching or furnace-cooling), and hold time (0 or 6 h at 800–980 °C). Microstructures were characterized by SEM and quantitative image analysis, from which secondary-carbide size, carbide volume fraction (CVF), and phase constituents were obtained.

The overall precipitation trajectory was governed by the heating rate: under slow heating, CVF and particle size were approximately three to five times higher than under fast heating, and the final microstructure was dominated by this difference. The cooling rate had a comparatively minor effect, except after fast heating, when furnace cooling produced additional fine carbides that increased CVF by about 70% without changing the mean size. A 6 h hold promoted coarsening; at 900 °C, CVF was maximized, whereas at 980 °C, a decrease in CVF with an increase in size indicated partial dissolution of small carbides. Slow-heated samples evolved gradually because substantial precipitation occurred during heating, whereas fast-heated samples changed mainly during the hold and cooling stages. Thus, heating rate, together with hold duration and cooling path, must be considered in process design.

高铬铸铁（HCCIs）通过控制热处理优化了耐磨性。通过改变加热速率（1或10°C/min）、冷却方式（水淬或炉冷）和保温时间（800-980°C 0或6 h），研究了26 wt% Cr的HCCI。通过扫描电镜和定量图像分析对微观组织进行了表征，获得了二次碳化物尺寸、碳化物体积分数（CVF）和相组成。整体析出轨迹受升温速率的支配，慢速升温下的CVF和粒度约为快速升温下的3 ~ 5倍，最终微观结构受此差异支配。除了快速加热之外，冷却速度对CVF的影响相对较小，当炉内冷却产生额外的细碳化物时，CVF增加了约70%，而平均尺寸没有改变。保温6 h促进粗化；在900°C时，CVF最大，而在980°C时，CVF随着尺寸的增加而减少，表明小碳化物部分溶解。由于加热过程中发生了大量的沉淀，缓慢加热的样品逐渐演变，而快速加热的样品主要在保持和冷却阶段发生变化。因此，在工艺设计中必须考虑加热速率、保温时间和冷却路径。

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引用次数: 0

Evaluation of the quasi-static compression properties of 3D printed polymer composite lattice structures 3D打印聚合物复合晶格结构的准静态压缩性能评价

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115482

Prince Jeya Lal Lazar , Vinoth Kumar Selvaraj , Jeyanthi Subramanian , Mathew Alphonse

3D-printed triply periodic minimal surface (TPMS) lattice structures can be tailored for desired mechanical properties. Previous studies focused on structures 3D-printed using conventional polymers. The present investigation evaluates and compares the compressive behaviour of Acrylonitrile butadiene styrene (ABS) and short carbon fibre-reinforced ABS (CF–ABS) TPMS lattices. Using fused filament fabrication, topologies like Schwarz Diamond, Schoen Gyroid, and Primitive tubular structures were developed and subjected to quasi-static axial compression experiments. Metrics such as compressive modulus, peak stress, plateau stress, specific energy absorption (SEA), and undulations in load-carrying capacity (ULCC) are evaluated. Results revealed that the Diamond lattices had the peak modulus and stress; furthermore, the ABS structures outperformed the CF-ABS by 5% and 7.8%, respectively. In CF-ABS lattices, plateau stress increased by 6.1%, 25.1%, and 10.5%, and SEA by 11.3%, 25.9%, and 10.6%, for Diamond, Gyroid, and Primitive, respectively. Additionally, CF-ABS lattices moderated ULCC, resulting in reductions of 21.6%, 43.3%, and 22.3% thereby enhancing load-carrying capacity. Diamond and Gyroid lattices failed through stretch-dominated failure, whereas Primitive structures failed through bending-dominated failure. Findings of this investigation confirm significant enhancements in energy absorption and plateau stress while limiting load-bearing fluctuations in composite lattices, which may help develop lightweight, high-performance composite structures.

3d打印三周期最小表面（TPMS）晶格结构可以定制所需的机械性能。以前的研究主要集中在使用传统聚合物进行3d打印的结构上。本研究评估和比较了丙烯腈-丁二烯-苯乙烯（ABS）和短碳纤维增强ABS (CF-ABS) TPMS晶格的压缩性能。利用熔丝制造技术，开发了Schwarz Diamond、Schoen Gyroid和Primitive管状结构等拓扑结构，并进行了准静态轴向压缩实验。诸如压缩模量、峰值应力、平台应力、比能量吸收（SEA）和承载能力波动（ULCC）等指标进行了评估。结果表明：金刚石晶格具有峰值模量和峰值应力；此外，ABS结构的性能比CF-ABS分别高出5%和7.8%。在CF-ABS晶格中，Diamond、Gyroid和Primitive晶格的高原应力分别增加了6.1%、25.1%和10.5%，SEA分别增加了11.3%、25.9%和10.6%。此外，CF-ABS晶格减缓了ULCC，导致减少21.6%，43.3%和22.3%，从而提高了承载能力。菱形和陀螺格的破坏是由拉伸主导的，而原始结构的破坏是由弯曲主导的。该研究结果证实了能量吸收和平台应力的显著增强，同时限制了复合材料晶格的承载波动，这可能有助于开发轻质、高性能的复合材料结构。

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引用次数: 0

A Z-scheme heterojunction sonozyme for enhanced sonodynamic and chemodynamic therapy through cascade amplification of ROS generation 一种通过级联扩增ROS生成来增强声动力和化学动力治疗的z型异质结声酶

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115493

BeiBei Zhang , MR Buyong , Dongmei Li , Bijiang Geng , MN Shafiee

The differential rate of reactive oxygen species (ROS) in cascade amplification can significantly improve the efficacy of sonodynamic/chemodynamic therapy (SDT/CDT). However, the currently developed sonozyme system composed of sonosensitizers and nanozymes not only has problems with low efficiency and poor stability, but also is limited by the abominable tumor microenvironment (TME). On this basis, we report a novel ROS yield cascade amplification strategy that combines the enhancement of sonosensitizer/nanozyme activity and regulation of TME. A bandgap-matched Z-scheme heterojunction with improved electron-hole separation kinetics is constructed by integrating biocompatible carbon dots (CDs) and Fe-based metal–organic frameworks (Fe-MOF). Using CDs as an auxiliary semiconductor can sensitize Fe-MOF by inhibiting the recombination of US-activated electron-hole pairs and accelerating the electron transfer efficiency, thereby enhancing the various enzyme-like simulated activities of Fe-MOF. Endowed with these advantages, the CD@Fe-MOF nanocomposite realizes cascade amplification of ROS production, which is achieved through enhancing SDT/CDT efficacy, scavenging glutathione GSH, and relieving tumor hypoxia. When CD@Fe-MOF is administered intravenously followed by US irradiation on tumor tissues, the constructed Z-scheme heterojunction nanoplatform enables complete tumor eradication with no recurrence. Overall, this study verifies the feasibility of using CDs as auxiliary semiconductors to sensitize sonosensitizers and nanozymes, while also offering novel insights for heterojunction engineering in tackling malignant tumors.

级联扩增中活性氧（ROS）的差异率可以显著提高声动力/化学动力治疗（SDT/CDT）的疗效。然而，目前开发的由声敏剂和纳米酶组成的声酶系统不仅存在效率低、稳定性差的问题，而且还受到恶劣肿瘤微环境（TME）的限制。在此基础上，我们报道了一种新的ROS产率级联扩增策略，该策略结合了声敏剂/纳米酶活性的增强和TME的调节。通过整合生物相容性碳点（CDs）和铁基金属有机骨架（Fe-MOF），构建了具有改进电子-空穴分离动力学的带隙匹配z型异质结。使用CDs作为辅助半导体可以通过抑制us激活的电子-空穴对的重组和加速电子转移效率来敏化Fe-MOF，从而增强Fe-MOF的各种酶样模拟活性。凭借这些优势，CD@Fe-MOF纳米复合材料通过增强SDT/CDT功效，清除谷胱甘肽GSH，缓解肿瘤缺氧，实现了ROS生成的级联扩增。当静脉给药CD@Fe-MOF后，肿瘤组织进行US照射，构建的z型异质结纳米平台可以完全根除肿瘤而不复发。总体而言，本研究验证了使用CDs作为辅助半导体致敏声敏剂和纳米酶的可行性，同时也为异质结工程治疗恶性肿瘤提供了新的见解。

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引用次数: 0

Gestational hypobaric hypoxia induces long-term biomechanical and structural alterations in the descending thoracic aorta 妊娠期低压缺氧可引起胸降主动脉的长期生物力学和结构改变

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-13 DOI: 10.1016/j.matdes.2026.115487

Álvaro Navarrete , Adolfo A. Paz , Andrés Utrera , G.K. Urrutia-Aguilera , Carlos Godoy-Guzmán , Cristian Astudillo-Maya , Tamara A. Jimenez , Emilio A. Herrera , Claudio García-Herrera

Chronic exposure to hypobaric hypoxia (HH) during gestation, typical of high-altitude environments (

\geq

2500 m), is known to affect fetal development; however, its long-term vascular consequences remain poorly understood. This study evaluated the biomechanical, functional, and morphostructural effects of gestational HH on the descending thoracic aorta (DTA) of adult guinea pigs. Pregnant animals were exposed to normoxia (group N) or HH (group H) during gestation, and offspring were maintained under normoxic conditions until one year of age. Mechanical behavior was characterized through tensile, ring-opening, and axial pre-stretching tests, while ex-vivo vasomotor function was assessed using wire myography and histological analysis. HH offspring showed increased material stiffness and residual strain, reduced axial physiological strain, diminished vasodilation, and enhanced vasoconstriction. Histology revealed thicker walls, larger luminal radii, elevated collagen and elastin content, and fewer endothelial cells compared to controls. These findings demonstrate that gestational HH induces persistent vascular remodeling, linking mechanical stiffening and endothelial dysfunction to a compensatory antihypertensive adaptation.

妊娠期慢性暴露于低气压缺氧（HH），典型的高海拔环境（≥2500米），已知会影响胎儿发育；然而，其对血管的长期影响仍知之甚少。本研究评估了妊娠期HH对成年豚鼠胸降主动脉（DTA）的生物力学、功能和形态结构影响。怀孕动物在怀孕期间暴露于常氧（N组）或HH （H组），并将后代维持在常氧条件下直到一岁。机械行为通过拉伸、开环和轴向预拉伸试验来表征，而离体血管舒缩功能通过钢丝肌图和组织学分析来评估。HH后代表现出材料刚度和残余应变增加，轴向生理应变降低，血管舒张减弱，血管收缩增强。组织学显示，与对照组相比，壁更厚，管腔半径更大，胶原蛋白和弹性蛋白含量升高，内皮细胞较少。这些发现表明妊娠HH诱导持续血管重构，将机械硬化和内皮功能障碍与代偿性降压适应联系起来。

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引用次数: 0