Materials & Design最新文献_第3页

Wet-spun hybrid hydrogel fibers exhibiting high electrical and mechanical stability in flexible electronics 湿纺杂化水凝胶纤维在柔性电子产品中表现出高的电气和机械稳定性

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-07 DOI: 10.1016/j.matdes.2026.115432

Animesh Sinha , Junho Kim , Sangyeun Park , Doheon Koo , Hongyun So

The ability to alter the crosslinking and network architectures of the three-dimensional polymers in hydrogels has prompted interest in their application in flexible electronics. However, ensuring long-term stability and balancing the mechanical strength and malleability of hydrogel materials remain challenging. This study accordingly synthesized ionic–electronic hydrogel fibers comprising a conductive Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PSS) polymer, a lithium chloride inorganic salt, COOH-functionalized multi-walled carbon nanotubes (CNTs), glycerol, and different weight percentages of polyvinyl alcohol (PVA). First, the numerous advantages of the proposed ∼300 μm diameter hydrogel fibers over bulk hydrogels were detailed. Next, the distinct hybrid organic–inorganic composition of the fibers was shown to maintain steady functioning, with stable ionic conduction, a clear frequency dependent trend and long-term stability. Furthermore, the crosslinking among the PVA, CNTs, and PSS molecules was determined to improve the stability of electrical conductivity. Finally, the fibers withstood strains in excess of 250 % for over six months while sustaining flexibility and functional integrity, and their relative variation in resistance under cyclic strain (1000 cycles) exhibited remarkable durability and dependability. Therefore, the hydrogel fibers were shown to be well-suited to use in commercial-level smart textiles, biomimetic soft robotics, and energy-harvesting applications such as wearable electronic devices.

改变水凝胶中三维聚合物的交联和网络结构的能力引起了人们对其在柔性电子中的应用的兴趣。然而，确保水凝胶材料的长期稳定性和平衡机械强度和延展性仍然是一个挑战。本研究因此合成了由导电聚（3,4-乙烯二氧噻吩）聚苯乙烯磺酸盐（PSS）聚合物、氯化锂无机盐、cooh官能化多壁碳纳米管（CNTs）、甘油和不同重量百分比的聚乙烯醇（PVA）组成的离子电子水凝胶纤维。首先，详细介绍了所提出的~ 300 μm直径水凝胶纤维相对于散装水凝胶的众多优点。其次，该纤维具有明显的有机-无机杂化结构，具有稳定的离子传导、明显的频率依赖趋势和长期稳定性。此外，还确定了PVA、CNTs和PSS分子之间的交联可以提高导电性能的稳定性。最后，纤维承受超过250%的应变超过6个月，同时保持柔韧性和功能完整性，并且在循环应变（1000次循环）下其相对阻力变化表现出显著的耐久性和可靠性。因此，水凝胶纤维被证明非常适合用于商业级智能纺织品、仿生软机器人和能量收集应用，如可穿戴电子设备。

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引用次数: 0

Vanadium microalloying to regulate CrV phase interface characteristics and dislocation configuration in FeNiCoCr-based high-entropy alloys 钒微合金化对fenicocr基高熵合金中CrV相界面特征和位错构型的调节

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-07 DOI: 10.1016/j.matdes.2026.115462

Zixian Xiong , Lei Zhang , Zhiyu Feng , Xinlong Zhang , Chunyu Zhao

This study utilizes vanadium microalloying to investigate the influence of CrV phase on the evolution of dislocation configurations in Fe₃₀Ni₂₀Co₂₀Cr₂₀Si_10-xV_x high-entropy alloys. Vanadium addition transforms Cr-rich phase into nanoscale CrV phase at low concentrations, promoting a perpendicular dislocation arrangement at phase boundaries. This microstructural evolution results in significant mechanical property improvements: the ultimate tensile strength (UTS) increases by 22.9 % (from 459.08 MPa to 564.29 MPa), while the elongation exhibits a remarkable 57.2 % enhancement (from 30.82 % to 48.44 %). With increasing vanadium content, the CrV phases undergo coarsening and facilitate intragranular slip, resulting in dislocation realignment parallel to the phase boundaries. Which further boosts ductility to 67.87 % while maintaining superior strength (533.38 MPa). These results illustrate that precise control of vanadium content enables a transition in CrV phase behavior, from dislocation pinning to slip channel formation. This study reveals critical microstructure-property relationships, enabling strength-ductility optimisation in high-entropy alloys.

本研究利用钒微合金化技术研究了CrV相对Fe30Ni20Co20Cr20Si10-xVx高熵合金中位错构型演变的影响。钒的加入使富cr相在低浓度下转变为纳米级的CrV相，促进了相边界的垂直位错排列。这种微观组织的演变导致了显著的力学性能改善：极限抗拉强度（UTS）提高了22.9%（从459.08 MPa提高到564.29 MPa），伸长率提高了57.2%（从30.82%提高到48.44%）。随着钒含量的增加，CrV相发生粗化，有利于晶内滑移，导致平行于相界的位错重新排列。进一步提高了67.87%的塑性，同时保持了优异的强度（533.38 MPa）。这些结果表明，精确控制钒含量可以实现CrV相行为的转变，从位错钉住到滑动通道的形成。这项研究揭示了关键的微观组织-性能关系，使高熵合金的强度-塑性优化成为可能。

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引用次数: 0

Misfit-dependent interaction mechanisms between γ-phase dislocations and interfacial dislocation networks in nickel-based single crystal superalloys under [001] tensile loading [001]拉伸载荷下镍基单晶高温合金γ相位错与界面位错网络的misfit依赖相互作用机制

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-07 DOI: 10.1016/j.matdes.2026.115437

Yifeng Xing , Wenyue Zhao , Wanxin Yu , Yi Ru , Shan Li , Bin Gan , Shengkai Gong , Huibin Xu

Understanding the dislocation–interface interaction mechanisms at atomic-scale is crucial for improving the temperature capacity of Ni-based single-crystal superalloys. This study develops an atomistic model challenging yet closer to real superalloys to investigate the interaction between a 1/2[1 1 0] screw dislocation on γ {1 1 1} plane and γ/γ’ interfacial dislocation network under [0 0 1] tensile stress via molecular dynamics simulations. Negative lattice misfits are explicitly incorporated into the γ/γ’ slab models by using Re- and temperature-dependent lattice constants, enabling realistic representations of interfacial geometry and stress. The simulations reveal two distinct misfit-controlled interaction modes during isothermal relaxation. One involves the formation of Lomer–Cottrell locks under low absolute misfit condition, and the other is characterized by dislocation loop evolution and delayed absorption under high absolute misfit. These modes obviously influence the early-stage dislocation behavior leading to maximum stress under uniaxial tensile loading. Moreover, the maximum tensile stress occurs simultaneously with the complete decomposition of the misfit dislocation network, thereby causing local necking within the γ phase. Parametric regression analysis further indicates that temperature, Re content and misfit jointly modulate the deformation of γ-γ’ at high temperature. These findings are expected to provide theoretical insights for interface stability and mechanical behavior in advanced superalloys.

在原子尺度上理解位错-界面相互作用机制对于提高镍基单晶高温合金的耐温能力至关重要。本研究建立了一个具有挑战性但更接近真实高温合金的原子模型，通过分子动力学模拟研究了在[0 0 1]拉应力下γ{1 11 1}平面上1/2[1 10 10]螺位错与γ/γ′界面位错网络之间的相互作用。通过使用依赖于Re和温度的晶格常数，将负晶格错配明确地纳入γ/γ '板模型中，从而实现界面几何形状和应力的真实表示。模拟揭示了等温弛豫过程中两种不同的非拟合控制的相互作用模式。一种是低绝对失配条件下lomo - cottrell锁的形成，另一种是高绝对失配条件下位错环的演化和延迟吸收。在单轴拉伸载荷作用下，这些模式明显影响导致最大应力的早期位错行为。此外，最大拉应力发生在错配位错网络完全分解的同时，从而导致γ相内的局部颈缩。参数回归分析进一步表明，温度、Re含量和失配共同调节γ-γ′在高温下的变形。这些发现有望为高级高温合金的界面稳定性和力学行为提供理论见解。

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引用次数: 0

A tumor microenvironment-triggered biomineralized nanoplatform synergizes with lypressin for tumor blockade therapy 肿瘤微环境触发的生物矿化纳米平台与ly加压素协同作用用于肿瘤阻断治疗

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2026.115460

Ke Li , Yufan Huang , Xiangjie Li , Qin Yin , Hao Gong , Aiguo Liu , Gang Zhao , Yu Liu

Clinical outcomes for osteosarcoma remain poor despite surgery and multi-agent chemotherapy. Biomineralization therapy can inhibit tumor growth by nucleating a calcified layer on the cancer cell surface, but its efficacy is limited by residual perfusion and metabolic compensation. Here, we report a tumor-microenvironment (TME)-responsive nanoplatform that integrates biomineralization with vascular infarction. Biomineralization-inducing nanoparticles (BMNPs) are electrostatically complexed with the vascular-blocking agent lysine vasopressin (LVP) to form BMNPs/LVP. In the acidic TME, BMNPs reorganize to chelate Ca²⁺ and deposit a pericellular calcified layer while simultaneously releasing LVP. The released LVP induces intratumoral thrombosis and vessel occlusion. This dual blockade synergistically restricts tumor proliferation and metastasis. In osteosarcoma models, BMNPs/LVP outperformed biomineralization monotherapy, yielding slower tumor growth, reduced metastatic burden, and prolonged survival, with favorable biocompatibility. These findings establish a biodegradable, tumor-targeted calcification-inducing nanoplatform combined with vascular infarction as a promising strategy for biomineralization-based cancer therapy.

尽管手术和多药化疗，骨肉瘤的临床结果仍然很差。生物矿化治疗可以通过在癌细胞表面形成一层钙化层来抑制肿瘤生长，但其效果受残余灌注和代谢代偿的限制。在这里，我们报道了一种肿瘤微环境（TME）响应纳米平台，该平台将生物矿化与血管梗死相结合。生物矿化诱导纳米颗粒（BMNPs）与血管阻断剂赖氨酸抗利尿素（LVP）静电络合形成BMNPs/LVP。在酸性TME中，BMNPs重组以螯合Ca2+并沉积细胞周钙化层，同时释放LVP。释放的LVP诱导肿瘤内血栓形成和血管闭塞。这种双重阻断协同抑制肿瘤的增殖和转移。在骨肉瘤模型中，BMNPs/LVP优于生物矿化单一疗法，肿瘤生长缓慢，转移负担减轻，生存期延长，具有良好的生物相容性。这些发现建立了一种生物可降解的、肿瘤靶向的钙化诱导纳米平台，结合血管梗死，作为一种基于生物矿化的癌症治疗的有希望的策略。

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引用次数: 0

Polyimide-based polymers: a new frontier in antimicrobial materials and healthcare applications 聚酰亚胺基聚合物：抗菌材料和医疗保健应用的新前沿

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2026.115453

Ashwaria Mehra , Munmun Chakraborty , Sasmita Nayak

Polyimide-based materials have emerged as versatile candidates due to their exceptional thermal stability, mechanical robustness, and chemical resistance. Recent research highlights their antimicrobial, antifouling, and biocompatible properties, offering promising solutions for infection control and device safety. These materials inhibit microbial growth on surfaces without compromising biocompatibility, making them ideal for healthcare applications and reducing device-related infections. This review emphasizes the biomedical applications of polyimides, particularly as antimicrobial coatings for implants, wound dressings, and medical devices. This emphasis stems from the critical need in healthcare to reduce infections and ensure device compatibility with human tissues, a role that polyimide-based materials appear exceptionally suited to fulfill. Despite their potential, several challenges persist, including long-term stability, limited biocompatibility assessments, and regulatory compliance, which necessitate interdisciplinary research efforts. By refining fabrication and surface engineering techniques, polyimide-based materials could significantly impact infection control practices and related complications. Further, the review provides a comprehensive overview of current advancements in polyimide research and highlights areas for future research, aimed at fully harnessing the antimicrobial and biocompatibility potential of polyimides in healthcare sector.

聚酰亚胺基材料由于其优异的热稳定性、机械稳健性和耐化学性而成为多功能候选材料。最近的研究强调了它们的抗菌、防污和生物相容性，为感染控制和设备安全提供了有前途的解决方案。这些材料在不影响生物相容性的情况下抑制表面微生物的生长，使其成为医疗保健应用和减少设备相关感染的理想选择。本文综述了聚酰亚胺在生物医学上的应用，特别是在植入物、伤口敷料和医疗器械上的抗菌涂层。这种强调源于医疗保健领域对减少感染和确保设备与人体组织兼容的迫切需求，聚酰亚胺基材料似乎特别适合满足这一角色。尽管它们具有潜力，但仍存在一些挑战，包括长期稳定性、有限的生物相容性评估和法规遵从性，这些都需要跨学科的研究努力。通过改进制造和表面工程技术，聚酰亚胺基材料可以显著影响感染控制实践和相关并发症。此外，综述了聚酰亚胺研究的最新进展，并指出了未来的研究领域，旨在充分利用聚酰亚胺在医疗保健领域的抗菌和生物相容性潜力。

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引用次数: 0

Optimization of structural and poling strategies in piezoelectric elastomer composites for soft sensing applications 软测量用压电弹性体复合材料的结构优化和极化策略

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2026.115457

Tasnim Missaoui , Xavier P. Morelle , Minh Quyen Le , Pierre-Jean Cottinet , Jean-Fabien Capsal , Guilhem Rival

Piezoelectric flexible sensors are emerging as key components in medical applications, offering unique electromechanical properties for various diagnostic and therapeutic purposes. In this study, ceramic-filled silicone composites were developed as high-performance piezoelectric materials suitable for soft biomedical sensing applications. To enhance their electromechanical response, a multi-parametric design strategy was adopted, combining three approaches: the use of bimodal particle size distribution and the dielectrophoretic alignment of these particles within the matrix, supported by an optimized poling process. Results revealed that composites with an oriented particle distribution, consisting of 25 % of micro-sized particles and 75 % of nano-sized particles exhibited significant improvements in piezoelectric coefficient (d₃₃) compared to composites with randomly distributed particles. Additionally, the piezoelectric transverse coefficient (d₃₁) was significantly improved under in situ poling conditions, particularly in nano-rich and hybrid systems. These findings underline the potential of combining particle alignment, size hybridization, and poling optimization in enhancing the performance of piezoelectric composites for innovative medical sensor applications.

压电柔性传感器是新兴的医疗应用的关键部件，为各种诊断和治疗目的提供独特的机电性能。在本研究中，陶瓷填充有机硅复合材料是一种高性能的压电材料，适用于软生物医学传感应用。为了增强其机电响应，采用了多参数设计策略，结合三种方法：使用双峰粒度分布和这些颗粒在矩阵内的介电泳排列，并通过优化的极化过程提供支持。结果表明，由25%的微颗粒和75%的纳米颗粒组成的定向颗粒分布的复合材料的压电系数（d33）比随机分布的复合材料有显著提高。此外，在原位极化条件下，特别是在富纳米和杂化体系中，压电横向系数（d31）显著提高。这些发现强调了结合颗粒排列、尺寸杂交和极化优化来提高压电复合材料在创新医疗传感器应用中的性能的潜力。

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引用次数: 0

Regularized ensemble: integrating frequentist-and-bayesian approach to polymer processing-to-property uncertainty 正则集成：将频率-贝叶斯方法集成到聚合物加工-性能不确定性中

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2025.115430

Han Liu , Liantang Li

Data-driven modeling of polymer processing–property relationship is key to predict and design polymeric product properties. However, this modeling is generally challenged by the lack of prediction uncertainty and reliability evaluation. Here, relying on Bayesian ensembling (BE) approach, we introduce a “regularized ensemble” (RE) strategy—featured by implementation convenience and uncertainty tunability—to evaluate polymer processing–property uncertainty, exemplified by neural network modeling of injection-molded polypropylene toughness. Inherited from BE approach to leverage and integrate Bayesian theory into frequentist statistics, we find that the RE model offers an accurate yet efficient uncertainty estimation when compared to baseline models using classical frequentist or Bayesian approach, including deep ensemble, Bayesian neural network, and Gaussian process regression. Impressively, trained by the real-world small, noisy dataset of 27 samplings in a 4-dimension design space of molding conditions, the RE model exhibits up to two times toughness predictability compared to baseline models, with the estimated uncertainty properly covering the experimental variations, enabling us to derive a stability metric to identify the promising process windows that yield stable specimens of high toughness. Overall, this work establishes an optimal uncertainty evaluation paradigm empowered by RE strategy, versatile to quantify prediction reliability of polymer processing–property modeling and generically material property designs.

聚合物加工-性能关系的数据驱动建模是预测和设计聚合物产品性能的关键。然而，由于缺乏预测的不确定性和可靠性评估，这种建模受到了普遍的挑战。本文以聚丙烯注塑成型韧性的神经网络建模为例，基于贝叶斯集成（BE）方法，引入了一种具有实现便便性和不确定性可调性的“正则化集成”（RE）策略来评估聚合物加工性能的不确定性。我们发现，与使用经典频率学或贝叶斯方法（包括深度集成、贝叶斯神经网络和高斯过程回归）的基线模型相比，RE模型提供了准确而有效的不确定性估计。令人印象深刻的是，通过在成型条件的4维设计空间中的27个样本的真实小而嘈杂的数据集进行训练，RE模型与基线模型相比显示出高达两倍的韧性可预测性，估计的不确定性适当地覆盖了实验变化，使我们能够得出一个稳定性度量来确定产生高韧性稳定样品的有希望的工艺窗口。总体而言，本研究建立了一个基于RE策略的最优不确定性评估范式，可用于量化聚合物加工性能建模和一般材料性能设计的预测可靠性。

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引用次数: 0

Engineering mesoporous silica nanoparticles for cancer immunotherapy: mechanistic insights, therapeutic synergies, and translational roadmap 工程介孔二氧化硅纳米颗粒用于癌症免疫治疗：机制见解，治疗协同作用和转化路线图

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2026.115452

Adel Mahmoudi Gharehbaba , Fatemeh Soltanmohammadi , Morteza Eskandani , Khosro Adibkia

Cancer immunotherapy has revolutionized oncology but remains constrained by the immunosuppressive tumor microenvironment (TME), systemic toxicities, and inadequate delivery of biologic agents. Nanotechnology offers a promising avenue to overcome these hurdles, with mesoporous silica nanoparticles (MSNs) emerging as a particularly versatile platform. This review comprehensively analyzes the application of MSNs in advancing cancer immunotherapy. We begin by outlining the current landscape of immunotherapies and their limitations. We then delve into the unique physicochemical properties of MSNs, and their direct impact on immune cell engagement and intrinsic adjuvanticity. The core of the review details strategic MSN-based approaches for innate and adaptive immune reprogramming, including antigen/danger signal co-delivery, surface engineering for targeted delivery, and combination with modalities like photodynamic/photothermal therapy to induce immunogenic cell death. Furthermore, we explore high-impact, underexplored frontiers such as MSN-mediated delivery of mRNA vaccines and CRISPR-Cas9 machinery for TME reprogramming. Finally, we critically assess the translational pathway, identifying key bottlenecks in safety, manufacturing, and regulatory approval, while providing a preclinical roadmap and a comparative analysis against clinical-stage nanocarriers. This synthesis underscores the potential of MSNs not merely as passive carriers, but as active, multifunctional immunomodulatory platforms poised to enhance the efficacy and specificity of next-generation cancer immunotherapies.

癌症免疫治疗已经彻底改变了肿瘤学，但仍然受到免疫抑制肿瘤微环境（TME）、全身毒性和生物制剂递送不足的限制。纳米技术为克服这些障碍提供了一条很有前途的途径，介孔二氧化硅纳米颗粒（MSNs）正成为一种特别通用的平台。本文综合分析了msn在推进肿瘤免疫治疗中的应用。我们首先概述免疫疗法的现状及其局限性。然后，我们深入研究了msn独特的物理化学性质，以及它们对免疫细胞接合和内在佐剂的直接影响。该综述的核心详细介绍了基于msn的先天性和适应性免疫重编程的战略方法，包括抗原/危险信号共递送，靶向递送的表面工程，以及与光动力/光热疗法等方式联合诱导免疫原性细胞死亡。此外，我们还探索了高影响力、未被充分开发的前沿领域，如msn介导的mRNA疫苗递送和用于TME重编程的CRISPR-Cas9机制。最后，我们批判性地评估了转化途径，确定了安全性、制造和监管批准方面的关键瓶颈，同时提供了临床前路线图和与临床阶段纳米载体的比较分析。这一合成强调了msn的潜力，它不仅可以作为被动载体，还可以作为主动的多功能免疫调节平台，增强下一代癌症免疫治疗的疗效和特异性。

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引用次数: 0

Thiol-ene click-functionalized polybutadiene elastomers achieve durable and biocompatible polyurethanes for long-term implantable systems 巯基点击功能化聚丁二烯弹性体为长期植入式系统实现耐用和生物相容性聚氨酯

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-06 DOI: 10.1016/j.matdes.2026.115455

Minghui Cui , Yu Liu , Guohui Tian , Junyi Zhou , Fenglong Li , Xiaolin Wang , Jing Chen , Haiming Chen , Jin Zhu , Jing Chen

Conventional polyurethanes for implants suffer from hydrolytic/oxidative degradation due to ester/ether bonds. To overcome this, in this research, we have developed aging-resistant implantable medical polyurethanes to address the issue of their limited durability. The synthesis involves ethanethiol for the click reaction-mediated elimination of the CC in terminal hydroxy polybutadiene (HTPB), resulting in the creation of HTPB-SH. Subsequently, an aging-resistant implantable polyurethane, HTPB-SH-PU, is synthesized. This material demonstrates not only remarkable thermal stability (T_d5%>290°C) but also superior mechanical performance, evidenced by a tensile strength of 35.1 MPa and an elongation at break of 196.74%. Moreover, HTPB-SH-PU is exhibiting outstanding aging resistance. In a hydrolysis aging test, it retains 71% of its tensile strength after 35 days, with negligible yellowing. To enhance biocompatibility, gastrodin is incorporated at various concentrations (0%, 0.5%, 1.0%, 2.0%), and the modified polyurethanes display excellent cytocompatibility, haemocompatibility, and histocompatibility. Therefore, the HTPB-SH-PU series represents a promising candidate for implantable medical devices such as pacemakers and artificial blood vessels, offering a solid theoretical foundation and material options for future research and development in medical polymers.

由于酯/醚键，用于植入物的传统聚氨酯容易水解/氧化降解。为了克服这一点，在这项研究中，我们开发了抗老化的植入式医用聚氨酯，以解决其有限的耐用性问题。该合成涉及乙硫醇，通过点击反应介导消除末端羟基聚丁二烯（HTPB）中的CC，从而产生HTPB- sh。随后，合成了一种耐老化的植入式聚氨酯HTPB-SH-PU。该材料不仅具有优异的热稳定性（Td5%>290°C），而且具有优异的力学性能，抗拉强度为35.1 MPa，断裂伸长率为196.74%。HTPB-SH-PU具有优异的耐老化性能。在水解老化试验中，35天后仍保持71%的抗拉强度，黄变可以忽略不计。为了提高生物相容性，天麻素以不同的浓度（0%、0.5%、1.0%、2.0%）掺入，改性聚氨酯具有良好的细胞相容性、血液相容性和组织相容性。因此，htpcb - sh - pu系列代表了植入式医疗设备（如起搏器和人造血管）的有希望的候选者，为未来医用聚合物的研究和开发提供了坚实的理论基础和材料选择。

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引用次数: 0

Tuning surface microtopography for optimum thermocompression bonding performance: structure, process parameters, and mechanisms on microfluidic chips 调整表面微形貌以获得最佳热压键合性能：微流控芯片的结构、工艺参数和机制

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-01-05 DOI: 10.1016/j.matdes.2026.115448

Baishun Zhao , Dimitrios Kontziampasis , Zhiyu Yang , Bingyan Jiang , Wangqing Wu (吴旺青) , Dou Zhang

The widespread application of microfluidic chips in biomedicine, life sciences, and food safety has generated industrialization demands, making it necessary to address key challenges in production costs and scalability. This work proposes the fabrication of an innovative microstructure in microfluidic chips to enhance thermocompression bonding performance. Through simulation, the stress mitigation effect of the energy-gathering rib (ER) and the resulting microchannel deformation are analyzed. This analysis subsequently feeds a redesign of the initial reference microchannel structure, acting as a guide. Experimental validation follows to confirm the enhancement of bonding performance by the ER. Results demonstrate that compared to the initial microchannel, the new design increases bonding strength by 123 % and reduces microchannel deformation by 6–8.46 %. Further analysis reveals that bonding strength increases by 160 % in the pressure range of 0.6–1.56 MPa. Additionally, this work advances the general understanding of the bonding strength formation mechanism by clearly elucidating the evolutionary behavior of interfacial morphology at the bonded interface. The generated knowledge accelerates the commercialization of microfluidic chips by directly improving the economic efficiency and sustainability of the fabrication process.

微流控芯片在生物医学、生命科学、食品安全等领域的广泛应用产生了产业化需求，需要解决生产成本和可扩展性方面的关键挑战。这项工作提出了一种创新的微流控芯片微结构的制造，以提高热压键合性能。通过仿真，分析了聚能肋的应力缓解效果以及由此产生的微通道变形。该分析随后提供了初始参考微通道结构的重新设计，作为指南。实验验证证实了ER对键合性能的增强。结果表明，与初始微通道相比，新设计的微通道结合强度提高了123%，微通道变形减少了6 - 8.46%。进一步分析表明，在0.6 ~ 1.56 MPa的压力范围内，结合强度提高了160%。此外，本工作通过清楚地阐明界面形态的演化行为，促进了对键合强度形成机制的一般理解。通过直接提高制造过程的经济效率和可持续性，所产生的知识加速了微流控芯片的商业化。

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引用次数: 0