Materials & Design最新文献_第10页

On the origin of spontaneous electrical oscillations in a minimal peptide assembly 最小肽组装中自发电振荡的起源

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-07 DOI: 10.1016/j.matdes.2026.115629

Salvatore Del Basso , Pietro Squeri , Rishit Mohan Ahuja , Rishav Karki , Giuseppe De Giorgio , Vardan Galstyan , Raffaele Martucci Zecca , Enrico Dalcanale , Xiongchuan Huang , Davide Vurro , Saksham Sharma , Pasquale D’Angelo , Andrew Adamatzky , Giuseppe Tarabella

The design of functional materials involves understanding how complex functionalities can emerge from simple material building blocks. In this context, peptide-based systems represent a versatile materials platform due to their chemical diversity, tunability and compatibility with sustainable processing routes. However, the conditions under which electrical functionality can emerge in minimal, abiotic peptide assemblies remain poorly understood. Here, we report the design and characterization of a minimal peptide-based material obtained through abiotic thermal polymerization, exhibiting spontaneous and persistent electrical oscillations under constant environmental conditions. The material is formed by the thermal condensation of four amino acids (Asp, Glu, Arg, Leu), resulting in a chemically heterogeneous ensemble of short oligomeric peptides. A comprehensive materials characterization combining DOSY NMR, HPLC-MS, FTIR, DLS, SEM, and qualitative Biuret assays reveals a disordered, proteinoid-like assembly with dynamic aggregation–disaggregation behaviour and strong coupling to ionic transport in the surrounding medium. Electrical measurements demonstrate autonomous oscillatory signals arising under constant environmental conditions and in the absence of external stimulation. Simultaneous dynamic light scattering and electrical measurements reveal a direct correlation between electrical oscillations and aggregation–disaggregation dynamics, indicating that the electrical activity emerges as a collective property of chemically heterogeneous peptide ensembles rather than from individual molecular species. These results provide experimentally grounded insight relevant to the design of peptide-based functional materials, highlighting minimal peptide assemblies as a promising platform for adaptive sensing, bio-inspired interfaces, and unconventional computing applications.

功能材料的设计包括理解如何从简单的材料构建块中产生复杂的功能。在这种情况下，基于肽的系统由于其化学多样性、可调性和与可持续加工路线的兼容性，代表了一个通用的材料平台。然而，电功能在最小的非生物肽组装中出现的条件仍然知之甚少。在这里，我们报告了通过非生物热聚合获得的最小肽基材料的设计和表征，该材料在恒定的环境条件下表现出自发和持续的电振荡。这种物质是由四种氨基酸（Asp, Glu, Arg, Leu）的热缩合形成的，从而形成化学上不均匀的短寡聚肽系。综合了DOSY NMR， HPLC-MS， FTIR， DLS， SEM和定性Biuret分析的材料表征揭示了一种无序的蛋白质样组装，具有动态聚集-分解行为，并与周围介质中的离子传输强耦合。电测量表明，在恒定的环境条件下，在没有外部刺激的情况下，会产生自主振荡信号。同时进行的动态光散射和电测量揭示了电振荡和聚集-分解动力学之间的直接关联，表明电活动是作为化学异质性肽集合的集体性质出现的，而不是来自单个分子物种。这些结果提供了与肽基功能材料设计相关的实验基础见解，突出了最小肽组装作为自适应传感，仿生界面和非常规计算应用的有前途的平台。

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引用次数: 0

High-density short aspen fiber networks have similar tensile properties as networks from longer spruce fibers 高密度短杨木纤维网与长云杉纤维网具有相似的拉伸性能

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-05 DOI: 10.1016/j.matdes.2026.115624

Erfan Oliaei , Bin Chen , Per-Oskar Westin , Lars A. Berglund

Mechanical behavior of high-density oriented spruce and aspen fiber networks from mildly delignified holocellulose fibers is investigated. Such recyclable, eco-friendly fiber networks are of interest for molded fiber materials and biocomposites. The aspen holocellulose fiber network showed excellent mechanical properties comparable to spruce despite much shorter fiber length. This contrasts with lower density “paper” structures from short fibers which show lower strength than spruce fiber networks. Present results are explained by improved interfiber shear strength and reduced critical fiber length. Microstructures and damage mechanisms were analyzed for materials design purposes using FE-SEM, wide-angle X-ray scattering (WAXS) and tensile testing with strain-field measurements using Digital Image Correlation (DIC).

研究了由轻度去木素化的全纤维素纤维制成的高密度取向云杉和杨木纤维网络的力学行为。这种可回收的、环保的纤维网络是模塑纤维材料和生物复合材料的兴趣。尽管纤维长度比云杉短得多，但杨木全纤维素纤维网络具有与云杉相当的优异力学性能。这与短纤维的低密度“纸”结构形成对比，短纤维的强度低于云杉纤维网络。目前的结果可以用纤维间抗剪强度的提高和临界纤维长度的减小来解释。利用FE-SEM、广角x射线散射（WAXS）和数字图像相关（DIC）应变场测量的拉伸测试分析了材料的微观结构和损伤机制。

引用次数: 0

Magnesium phosphate cement modulates osteosarcoma stemness and osteogenesis via IGFBP5 activation for localized tumor therapy 磷酸镁水泥通过激活IGFBP5调控骨肉瘤的干性和成骨作用，用于局部肿瘤治疗

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.matdes.2026.115643

Ling Yu , Jingteng Chen , Dongdong Shi , Shiyu Li, Zhangxin Chen, Weichun Guo

Osteosarcoma remains a clinical challenge due to aggressive bone destruction and cancer stem cell (CSC)-driven recurrence. While magnesium phosphate cement (MPC) is widely recognized for its osteoregenerative properties, its therapeutic potential in bone malignancies is largely unexplored. Here, we systematically evaluated MPCs with varying Mg/P ratios (MPC-1 ∼ 5) for their antitumor and pro-differentiation effects against osteosarcoma. MPC1 ∼ 3 demonstrated dose-dependent suppression of tumor growth, migration, and aggression, while MPC-5 elicited significant cytotoxicity. Notably, MPC-1 ∼ 3 suppressed CSC markers and promoted osteogenic differentiation, evidenced by matrix mineralization and upregulation of osteogenic transcription factors. In orthotopic and metastatic mouse models, MPC treatment significantly reduced tumor burden and pulmonary metastasis, alongside elevated expression of osteogenic markers (OPN, Runx2, Collagen-I). Mechanistically, MPCs upregulated insulin-like growth factor binding protein 5 (IGFBP5), that mediated stemness suppression and differentiation induction; silencing IGFBP5 reversed these effects. These findings identify MPC as a bifunctional biomaterial with both antitumor and osteoinductive properties, offering a promising strategy for osteosarcoma therapy via stemness-targeted differentiation.

骨肉瘤仍然是一个临床挑战，由于侵略性骨破坏和癌症干细胞（CSC）驱动的复发。虽然磷酸镁骨水泥（MPC）因其骨再生特性而被广泛认可，但其在骨恶性肿瘤中的治疗潜力在很大程度上尚未被探索。在这里，我们系统地评估了不同Mg/P比率（MPC-1 ~ 5）的MPCs对骨肉瘤的抗肿瘤和促分化作用。MPC1 ~ 3表现出剂量依赖性的肿瘤生长、迁移和侵袭抑制，而MPC-5则引起显著的细胞毒性。值得注意的是，MPC-1 ~ 3抑制CSC标记物并促进成骨分化，这可以通过基质矿化和成骨转录因子上调来证明。在原位和转移小鼠模型中，MPC治疗显著降低了肿瘤负荷和肺转移，同时提高了成骨标志物（OPN、Runx2、胶原- i）的表达。在机制上，MPCs上调胰岛素样生长因子结合蛋白5 (IGFBP5)，介导干性抑制和分化诱导；沉默IGFBP5逆转了这些影响。这些发现表明MPC是一种具有抗肿瘤和骨诱导特性的双功能生物材料，为通过干细胞靶向分化治疗骨肉瘤提供了一种有希望的策略。

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引用次数: 0

Cover_263 Cover_263

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-03-03 DOI: 10.1016/S0264-1275(26)00289-3

引用次数: 0

From external to internal Light: Designs, Mechanisms, applications and Prospects of wireless photodynamic therapy in cancer 从外部光到内部光：无线光动力治疗癌症的设计、机制、应用与展望

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115618

Adel Habibul, Jiaquan Mao, Sheng Xin, Jun Zhang, Wen Song, Xiaodong Song, Kun Tang

Photodynamic therapy (PDT) utilizes light-activated photosensitizers to generate cytotoxic reactive oxygen species (ROS) in tumors and is clinically applied across diverse cancers. Nevertheless, traditional wired-PDT is limited by restricted optical penetration, spatially heterogeneous intratumoral illumination, and the procedural burden of invasive fiber delivery. Wireless PDT addresses these issues by producing photons in situ with implantable opto-electronic devices, light-converting nanomaterials and self-luminescent nanoparticles, thereby activating photosensitizers from inside the body. This mode of wireless PDT improves depth reach and spatial uniformity while omitting fiber-based access, and it permits a more feasible way for metronomic PDT that sustains intratumoral oxygenation and ROS production while minimizing thermal damage and hypoxia-driven immunosuppression. Building on these advances, we elaborate the idea of wireless PDT and outline a novel contour for the future of photodynamic therapy in cancer treatment.

光动力疗法（PDT）利用光激活的光敏剂在肿瘤中产生细胞毒性活性氧（ROS），临床上应用于多种癌症。然而，传统的有线pdt受限于有限的光穿透，肿瘤内空间不均匀的照明以及侵入性光纤传输的程序负担。无线PDT解决了这些问题，通过使用可植入的光电器件、光转换纳米材料和自发光纳米颗粒在原位产生光子，从而从体内激活光敏剂。这种无线PDT模式提高了深度到达和空间均匀性，同时省去了基于光纤的接入，它为维持肿瘤内氧合和ROS产生，同时最大限度地减少热损伤和缺氧驱动的免疫抑制的节拍性PDT提供了一种更可行的方法。在这些进展的基础上，我们详细阐述了无线PDT的想法，并为未来的光动力治疗癌症勾勒出一个新的轮廓。

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引用次数: 0

Strain-rate-dependent dislocation-martensite interactions in Fe-Mn-Al-Nb medium manganese steel via discrete dislocation dynamics modeling 基于离散位错动力学模型的Fe-Mn-Al-Nb中锰钢中应变速率相关位错-马氏体相互作用

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.matdes.2026.115586

Ning Guo , Xinping Ji , Bingtao Tang , Jilai Wang

Medium manganese steels (MMnS) exhibit exceptional strength-ductility synergy due to the well-known transformation induced plasticity (TRIP) effects, making it a prime candidate for automotive lightweighting and safety–critical structures. However, the strain-rate-dependent dislocation-martensite interactions governing its strain hardening and plasticity remain incompletely understood, particularly regarding dynamic loading conditions. To address this gap, this study employs an integrated experimental-computational approach by combining dynamic tensile tests (1000–3000 s⁻¹) via split Hopkinson bar apparatus, microstructural characterization, and a novel 3D discrete dislocation dynamics (DDD) model simulating dislocation evolution in austenite–martensite systems. Key findings demonstrate that elevated strain rates enhance yield strength by 12.7 %, primarily through intensified dislocation density and dislocation cell formation, though this concurrently exacerbates strain localization. Furthermore, closer dislocation-martensite proximity (300–1200 nm) significantly increases the critical stress required for dislocation accumulation ahead of martensite. Notably, successful bypassing triggers abrupt macroscopic stress drops followed by rapid dislocation proliferation. Critically, martensite promotes dislocation accumulation and induces secondary hardening; its 45° orientation activates distinct slip systems that accumulate higher dislocation densities, yielding the maximum strength. These insights elucidate dislocation-mediated strengthening under dynamic loading, establishing a microstructure-guided framework for designing advanced high-performance steels.

由于众所周知的相变诱导塑性（TRIP）效应，中锰钢（MMnS）表现出卓越的强度-延性协同作用，使其成为汽车轻量化和安全关键结构的首选材料。然而，控制其应变硬化和塑性的应变速率相关位错-马氏体相互作用仍然不完全清楚，特别是在动态加载条件下。为了解决这一问题，本研究采用了一种综合的实验-计算方法，通过分离式霍普金森杆装置进行动态拉伸试验（1000-3000 s−1），微观结构表征和一种新的三维离散位错动力学（DDD）模型来模拟奥氏体-马氏体系统中的位错演变。主要研究结果表明，应变速率的提高使屈服强度提高了12.7%，这主要是通过强化位错密度和位错细胞的形成，尽管这同时加剧了应变局部化。此外，位错与马氏体的距离越近（300-1200 nm），位错积累所需的临界应力显著高于马氏体。值得注意的是，成功的旁路触发了突然的宏观应力下降，随后是位错的快速扩散。重要的是，马氏体促进位错积累并诱导二次硬化；它的45°取向激活了不同的滑移系统，积累了更高的位错密度，产生了最大的强度。这些见解阐明了动态载荷下位错介导的强化，为设计先进高性能钢建立了微观结构指导框架。

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引用次数: 0

Effect of bimodal heterostructure features on strength-ductility trade-off breaking in Inconel 718 Ni-based superalloy 双峰异质组织特征对Inconel 718镍基高温合金强度-塑性平衡断裂的影响

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.matdes.2026.115587

Zihao Jiang , Nanping Yue , Junpeng Ren , Lei Zhou , Yingfei Guo , Pingwei Xu , Fei Zhao , Longxiang Wang , Yonghai Ren , Zhiguo Dong , Yu Liang

A bimodal heterostructure with alternating δ phase-rich fine-grained (FG) and δ phase-lean coarse-grained (CG) regions was constructed in Inconel 718 via the selective precipitation of the δ phase, enabled by controlled Nb content and heat treatment. Compared to the homogeneous counterpart, the optimal heterostructure achieves a significant enhancement in yield strength (222 MPa increase) and ultimate tensile strength (213 MPa increase) while maintaining good ductility. Multiscale characterization revealed an effective heterointerface influence range of ∼22 μm. CG regions beyond this effective range exhibits quasi-homogeneous deformation, thereby impeding dynamic strain partitioning and HDI strengthening that arise from the accumulation of geometrically necessary dislocations (GNDs). Notably, a stress equilibrium mechanism is identified. When the coarse grain size is moderate and the proportion of FG regions is sufficiently high, the forward stress generated by dislocation pile-ups can be effectively borne by the FG regions and transformed into beneficial work hardening. Conversely, under the condition of excessively large coarse grains and a low FG regions fraction, the local stress at the heterointerface is likely to exceed the accommodation limit, triggering premature microcrack initiation in FG regions and a loss of the synergy. This work provides a strategy for designing heterostructure via second-phase engineering.

在控制Nb含量和热处理的条件下，通过δ相的选择性析出，在Inconel 718中形成了富δ相细晶区（FG）和贫δ相粗晶区（CG）交替的双峰异质结构。与均相异质结构相比，最优异质结构在保持良好延性的同时，屈服强度（增加222 MPa）和极限抗拉强度（增加213 MPa）显著提高。多尺度表征表明，异质界面的有效影响范围为~ 22 μm。超过此有效范围的CG区域表现出准均匀变形，从而阻碍了动态应变分配和由几何必要位错（GNDs）积累引起的HDI强化。值得注意的是，确定了应力平衡机制。当粗晶粒尺寸适中且FG区比例足够高时，位错堆积产生的正向应力可以有效地由FG区承担，并转化为有益的加工硬化。相反，在过大的粗晶和较低的FG区分数的情况下，异质界面处的局部应力很可能超过容纳极限，导致FG区过早微裂纹萌生，失去协同作用。本工作为异质结构的二期工程设计提供了策略。

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引用次数: 0

The mechanism of natural age-strengthening of grey cast iron: PEC-ageing 灰口铸铁的自然时效强化机制：pec时效

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.matdes.2026.115536

Juan Manuel Bello Bermejo , Jesús Carrero Robles , Huaiyu Chen , Megan O. Hill Landberg , Jesper Wallentin , Johan Hektor , Lena Magnusson Åberg , Henrik Borgström , Filip Lenrick

In this work we introduce the concept of natural ageing via precipitation arising from eutectic cell structure (PEC-ageing). Natural age-strengthening in grey cast iron at room temperature is long recognised yet still poorly understood, despite its beneficial effect on tensile strength and machinability. We investigate its underlying mechanisms by comparing fresh and naturally aged industrial grey cast iron using high-resolution synchrotron Wide-Angle X-ray Scattering (WAXS), complemented by scanning electron microscopy and X-ray energy-dispersive spectroscopy. A strict sample-preparation process was designed to minimize artificial ageing and X-ray attenuation artefacts. We present direct experimental evidence of an X-ray diffraction peak that forms upon natural ageing in grey cast iron. Based on its position in reciprocal space, a plausible candidate for this peak is the iron nitride phase

Fe_{4} N

. Spatially resolved analysis further shows that this phase is strongly localised along eutectic cell boundaries, supporting a nitride-related, boundary-mediated precipitation mechanism (PEC-ageing) as the main driver of the ageing phenomenon. These results provide a spatially resolved description of natural ageing in grey cast iron, establish WAXS as a powerful tool to track ageing-related changes in the bulk, and highlight that logistics and sample preparation remain the main practical challenges for future in-situ studies.

在这项工作中，我们引入了由共晶细胞结构引起的沉淀自然老化的概念（pec -老化）。尽管灰口铸铁在室温下的自然时效强化对抗拉强度和可加工性有有益的影响，但人们早就认识到这一点，但对它的了解仍然很少。我们利用高分辨率同步加速器广角x射线散射（WAXS），辅以扫描电子显微镜和x射线能量色散光谱，比较新鲜和自然老化的工业灰铸铁，研究其潜在机制。设计了严格的样品制备工艺，以尽量减少人工老化和x射线衰减伪影。我们提出了一个x射线衍射峰，形成在灰铸铁自然老化的直接实验证据。根据其在互反空间中的位置，这个峰的合理候选是氮化铁相FeX4N。空间分辨分析进一步表明，该相在共晶细胞边界强烈局部化，支持与氮化物相关的边界介导沉淀机制（pec -时效）是老化现象的主要驱动因素。这些结果提供了灰铸铁自然老化的空间解析描述，建立了WAXS作为跟踪体积老化相关变化的强大工具，并强调物流和样品制备仍然是未来原位研究的主要实际挑战。

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引用次数: 0

Influence of process parameters on interlayer interface mechanical properties of 3D printing fiber reinforced concrete 工艺参数对3D打印纤维增强混凝土层间界面力学性能的影响

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1016/j.matdes.2026.115539

Lei Feng , Nuo Chen , Xiao-dong Wen

The layer-by-layer deposition in concrete 3D printing creates weak interlayer interfaces, posing risks to structural integrity. This study systematically investigates the effects of printing parameters (layer height, speed, interlayer time intervals) and material composition on interlaminar tensile/shear strength and defect formation mechanisms using an experimental-computational approach. Results demonstrate that mechanical performance inversely correlates with layer height, printing speed, and interlayer intervals: reducing layer height from 15 mm to 5 mm elevates tensile strength by 186.85 %, while decreasing printing speed from 50 mm/s to 30 mm/s improves interlaminar tensile strength by 50.7 %. Continuous printing enhances interlaminar tensile and shear strengths by 77.18 % and 45.96 %, respectively, compared to 24-hour delayed printing. Microstructural analysis identifies crack width expansion as the primary cause of interfacial weakening. A mechanics-driven numerical model was established to quantify process-property relationships, predicting interlaminar tensile/shear forces with <5 % deviation from experimental measurements. Validation confirmed that the model can integrate and push out key parameters (layer height: 13–26 mm; Speed: 22–92 mm/s) for optimal bonding in line with industry specifications. This work provides a predictive framework for optimizing 3D-printed concrete structures by balancing process efficiency and interfacial durability, advancing the design of robust additive-manufactured construction components.

在混凝土3D打印中，逐层沉积会产生较弱的层间界面，对结构完整性构成风险。本研究系统地研究了打印参数（层高度、速度、层间时间间隔）和材料成分对层间拉伸/剪切强度和缺陷形成机制的影响。结果表明：层高、打印速度、层间间隔与力学性能呈负相关：层高从15 mm降低到5 mm，层间拉伸强度提高186.85%，打印速度从50 mm/s降低到30 mm/s，层间拉伸强度提高50.7%。与24小时延迟打印相比，连续打印可使层间拉伸强度和剪切强度分别提高77.18%和45.96%。微观结构分析表明，裂纹宽度扩展是导致界面弱化的主要原因。建立了一个力学驱动的数值模型来量化工艺性能关系，预测层间拉伸/剪切力与实验测量值偏差<； 5%。验证证实，该模型可以集成并推出关键参数（层高：13-26 mm；速度：22-92 mm/s），以实现符合行业规范的最佳粘合。这项工作通过平衡工艺效率和界面耐久性，为优化3d打印混凝土结构提供了一个预测框架，推进了坚固的增材制造建筑部件的设计。

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引用次数: 0

A tumor microenvironment-triggered biomineralized nanoplatform synergizes with lypressin for tumor blockade therapy 肿瘤微环境触发的生物矿化纳米平台与ly加压素协同作用用于肿瘤阻断治疗

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design

Pub Date : 2026-02-01 Epub Date: 2026-01-06 DOI: 10.1016/j.matdes.2026.115460

Ke Li , Yufan Huang , Xiangjie Li , Qin Yin , Hao Gong , Aiguo Liu , Gang Zhao , Yu Liu

Clinical outcomes for osteosarcoma remain poor despite surgery and multi-agent chemotherapy. Biomineralization therapy can inhibit tumor growth by nucleating a calcified layer on the cancer cell surface, but its efficacy is limited by residual perfusion and metabolic compensation. Here, we report a tumor-microenvironment (TME)-responsive nanoplatform that integrates biomineralization with vascular infarction. Biomineralization-inducing nanoparticles (BMNPs) are electrostatically complexed with the vascular-blocking agent lysine vasopressin (LVP) to form BMNPs/LVP. In the acidic TME, BMNPs reorganize to chelate Ca²⁺ and deposit a pericellular calcified layer while simultaneously releasing LVP. The released LVP induces intratumoral thrombosis and vessel occlusion. This dual blockade synergistically restricts tumor proliferation and metastasis. In osteosarcoma models, BMNPs/LVP outperformed biomineralization monotherapy, yielding slower tumor growth, reduced metastatic burden, and prolonged survival, with favorable biocompatibility. These findings establish a biodegradable, tumor-targeted calcification-inducing nanoplatform combined with vascular infarction as a promising strategy for biomineralization-based cancer therapy.

尽管手术和多药化疗，骨肉瘤的临床结果仍然很差。生物矿化治疗可以通过在癌细胞表面形成一层钙化层来抑制肿瘤生长，但其效果受残余灌注和代谢代偿的限制。在这里，我们报道了一种肿瘤微环境（TME）响应纳米平台，该平台将生物矿化与血管梗死相结合。生物矿化诱导纳米颗粒（BMNPs）与血管阻断剂赖氨酸抗利尿素（LVP）静电络合形成BMNPs/LVP。在酸性TME中，BMNPs重组以螯合Ca2+并沉积细胞周钙化层，同时释放LVP。释放的LVP诱导肿瘤内血栓形成和血管闭塞。这种双重阻断协同抑制肿瘤的增殖和转移。在骨肉瘤模型中，BMNPs/LVP优于生物矿化单一疗法，肿瘤生长缓慢，转移负担减轻，生存期延长，具有良好的生物相容性。这些发现建立了一种生物可降解的、肿瘤靶向的钙化诱导纳米平台，结合血管梗死，作为一种基于生物矿化的癌症治疗的有希望的策略。

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引用次数: 0