Microchemical Journal最新文献

{"title":"Biomarker for the toxicity evaluation of cadmium based on Glutathione: Recent Progress and challenges","authors":"Lukman Iddrisu ,&nbsp;Evodia Moses Mkulo ,&nbsp;Felix Danso ,&nbsp;Mpwaga Alatwinusa Yohana ,&nbsp;Yinyan Chen ,&nbsp;Zhijia Fang ,&nbsp;Ravi Gooneratne","doi":"10.1016/j.microc.2024.111935","DOIUrl":"10.1016/j.microc.2024.111935","url":null,"abstract":"<div><div>There is growing global concern regarding the prevalence of heavy metal ions, such as cadmium, which pose increasing risks to both the environment and human health. Exposure to metals such as mercury, lead, cadmium, and manganese, can result in serious neurological impairments, including Parkinson’s disease, epilepsy, and olfactory dysfunction, particularly affecting olfactory neurons. Recent research has focused on developing accurate and precise methods for detecting Cd, as there is an increasing demand for cost-effective, sensitive, specific, and rapid detection techniques. One promising approach is the use of glutathione (GSH) biomarker, which offer timely, affordable, and user-friendly detection. These biomarkers have been integrated with various transducers such as electrochemical, optical, and fluorescent platforms to enhance detection sensitivity. Electrochemical biosensors leverage the redox properties of GSH to achieve low detection limits and quick response times, whereas optical biosensors rely on the GSH-Cd²⁺ complexation process to produce observable spectral changes. Fluorescent biosensors utilize GSH-mediated fluorescence quenching or amplification to detect trace amounts of Cd with high sensitivity. To address the challenges in detection, researchers are exploring the use of nanomaterials to enhance signal transmission and sensor durability, as well as to incorporate selective membranes to improve specificity. GSH-based biosensors are continuously evolving and hold promise for applications in environmental monitoring, food safety, and biomedical fields, with the aim of identifying the health risks associated with Cd exposure.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111935"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Polythiophenes: Pioneering imprinted and functionalized materials in biosensor technology","authors":"Salah M. Tawfik ,&nbsp;Mirkomil Sharipov ,&nbsp;Mohamed R. Elmasry ,&nbsp;Shavkatjon Azizov ,&nbsp;Dong-Hwan Kim ,&nbsp;Abbaskhan Turaev ,&nbsp;Yong-Ill Lee ,&nbsp;Hoon Eui Jeong","doi":"10.1016/j.microc.2024.111947","DOIUrl":"10.1016/j.microc.2024.111947","url":null,"abstract":"<div><div>Smart designs beyond the limitations of the biosensors present fascinating opportunities for portable, flexible, versatile, and effective performance that allow for the rapid in-vivo, and real-time detection of potential targets. Conjugated polythiophenes (CPTs) are particularly valuable as biosensors because of their remarkable brightness, excellent photostability, and low toxicity. CPTs potentially molecularly self-assemble using an imprinted method resulting in imprinted conjugated polythiophenes (ICPTs). ICPTs combined the distinctive characteristics of CPTs with the excellent selectivity arising from robustly particular binding sites of molecular imprinting. ICPT-based biomimetic sensors represent a specialized subset within this extensive field. An overview of various types of CPT-based sensors was described to achieve a systematic analysis. These included biosensors based on printing technologies, microfluidic systems, film transistors, colorimetric methods, and electrochemical approaches. Additionally, we discussed the optical-electrical properties, and sub-types of polythiophene derivatives examining their specific applications and advantages in biosensor technology. The final section provided an in-depth exploration of the imprinted techniques employed in developing ICPTs-based sensors, with particular emphasis on applications in biochemical sensing.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111947"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and application of novel biosensors for enhanced detection in medical diagnostics","authors":"A.M. Elbasiony ,&nbsp;Sarah Alharthi ,&nbsp;Mohamed Mohamady Ghobashy ,&nbsp;Waleed E. Boraie ,&nbsp;Mohamed S. Attia ,&nbsp;Mohamed Madani ,&nbsp;Samera Ali Al-Gahtany ,&nbsp;Reem Darwesh ,&nbsp;Mohamed Shaban ,&nbsp;A.I. Sharshir","doi":"10.1016/j.microc.2024.111938","DOIUrl":"10.1016/j.microc.2024.111938","url":null,"abstract":"<div><div>Biosensors have emerged as crucial medical diagnostics and environmental monitoring tools, offering high sensitivity, specificity, and rapid detection capabilities. This review highlights recent advancements in biosensor technologies, mainly focusing on integrating nanomaterials such as carbon nanotubes (CNTs), graphene oxide, and gold nanoparticles. These nanomaterials enhance biosensor performance by increasing surface area, facilitating electron transfer, and providing tunable functionalization options essential for capturing and detecting analytes. The review explores applications of biosensors in the early detection of diseases, where detecting biomarkers at low concentrations is critical for timely medical intervention. Furthermore, the application of biosensors in environmental monitoring is discussed, emphasizing their role in detecting pollutants and ensuring safety standards. Special attention is given to epidermal biosensors for non-invasive monitoring and their distinguishing features compared to other biosensors. Despite the significant progress in biosensor development, challenges such as stability, reproducibility, and real-world integration remain. Addressing these challenges is crucial for the widespread adoption of biosensors in clinical and environmental settings.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111938"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting C-peptide using biosensors for diagnosis and monitoring of disease","authors":"Zahra Jamalizadeh Bahaabadi ,&nbsp;Prashant Kesharwani ,&nbsp;Amirhossein Sahebkar","doi":"10.1016/j.microc.2024.111922","DOIUrl":"10.1016/j.microc.2024.111922","url":null,"abstract":"<div><div>The connecting peptide (C-peptide) is a short polypeptide that connects the A-chain to the B-chain in the proinsulin molecule. This biomarker is secreted into the blood circulation in the same amount as insulin and has a longer half-life than it. Measuring blood serum levels of C-peptide can be used to distinguish between different diabetes types. Also, the amount of C-peptide in body fluids as an indicator has been used to evaluate pancreatic beta‐cell function. However, a reliable and fast method is essential to quantify the amount of C-peptide in biological fluids and its significance in the control and diagnosis of disease. Over the years, several studies have used biosensors to detect C-peptide levels in real samples. These studies focused on speeding up detection and creating novel detection techniques. Biosensor-based methods can potentially improve the diagnosis and monitoring of diabetes. This review aims to provide a general overview of the various C-peptide biosensors in relation to their detection limit and potential point-of-care uses.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111922"},"PeriodicalIF":4.9,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of new emerging biosensors based on bacteria-imprinted polymers towards pathogenic bacteria: Promising new tools for selective detection","authors":"Chou-Yi Hsu ,&nbsp;Jasur Alimdjanovich Rizaev ,&nbsp;Harikumar Pallathadka ,&nbsp;Sofiene Mansouri ,&nbsp;Dmitry Olegovich Bokov ,&nbsp;Snehlata Sharma ,&nbsp;Gulshan Rathore ,&nbsp;Pranchal Rajput ,&nbsp;Yasser Fakri Mustafa ,&nbsp;Munther Kadhim Abosaoda","doi":"10.1016/j.microc.2024.111918","DOIUrl":"10.1016/j.microc.2024.111918","url":null,"abstract":"<div><div>The spread of pathogenic bacteria in the environment, as a significant global issue, causes a substantial threat to human health, damaging economic development. Indeed, the development of sensitive and selective sensing approaches for detection of pathogenic bacteria is essential to prevent and treating infections. In this regard, biosensors as efficient analytical methods can play an important role. Importantly, exploiting of novel strategy can improve the performance of these biosensing platforms. Among different types, molecularly imprinted polymers (MIPs), as artificial receptors, that are developed to selective and sensitive biosensors. The distinct complementary cavities in these synthetic polymers contribute to their unique characteristics, as they are specifically tailored to their respective templates. Notably, bacteria-imprinted polymers (BIPs), as an important and novel member of MIPs, attracted considerable attention for different bacteria detection due to many cavities complementary to their bacteria. These novel probes can efficiently isolate various bacteria from wide range of samples such as food, water, or biological fluids due to the high affinity and selectivity. In this study, the application of BIPs in the structure of biosensors, as active area of research in the field of different bacteria detection, was reviewed for detection of <em>Staphylococcus aureus</em> (<em>S. aureus</em>), <em>Salmonella</em>, <em>Vibrio parahaemolyticus</em> (<em>(V. parahaemolyticus</em>) and <em>Escherichia coli</em> (<em>E. coli</em>). In addition, direct strategies and advance methods for bacteria imprinting completely reviewed. The deficiency and future perspective of BIPs sensors were discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111918"},"PeriodicalIF":4.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomass-based adsorbents for wastewater remediation: A systematic review on removal of emerging contaminants","authors":"Nishita Sharma ,&nbsp;Aruna Yadav ,&nbsp;Sarita Yadav ,&nbsp;Partiksha Panghal ,&nbsp;Sonika Singh ,&nbsp;Aakash Deep ,&nbsp;Surender Kumar","doi":"10.1016/j.microc.2024.111880","DOIUrl":"10.1016/j.microc.2024.111880","url":null,"abstract":"<div><div>As anthropogenic activities, industrialization, and technology have grown exponentially in recent decades, the presence of emerging contaminants (ECs) is increasing stress on fresh and sustainable water supplies due to their environmental toxicity. Therefore, a holistic approach is urgently required for the development of efficient technologies to bring the idea of wastewater remediation to fruition. Adsorption with biomass-based adsorbents can contribute to this perception as it offers numerous advantages over existing wastewater treatment technologies. This review ensures a thorough analysis of the potential application of natural sustainable adsorbents based on biomass for efficient removal of ECs including pharmaceuticals and personal care products (PPCPs), agrochemicals, aromatics, and microplastics (MPs). Various factors impacting the adsorption efficiency such as adsorbent dosage, concentration, contact time, pH, and temperature, along with the best-fitted models have been provided for the critical literature analysis. The adsorption mechanism involved was reviewed based on the point of zero charges of adsorbents, the ionic form of adsorbate, the hydrophobicity of adsorbate and adsorbent, surface functional groups, etc. Further, literature gaps were also identified and discussed for directing future research needed in the development of inexpensive, eco-friendly, efficient, reusable adsorbents with the overall process based on circular bio-economy and 4R (Reduce, Recycle, Re-use and Recover) approach, so that it can be commercialized to promote more sustainable futures.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111880"},"PeriodicalIF":4.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoplastics as emerging contaminants: A systematic review of analytical processes, removal strategies from water environments, challenges and perspective","authors":"Asiyeh Moteallemi ,&nbsp;Mohammad Hadi Dehghani ,&nbsp;Fatemeh Momeniha ,&nbsp;Salah Azizi","doi":"10.1016/j.microc.2024.111884","DOIUrl":"10.1016/j.microc.2024.111884","url":null,"abstract":"<div><div>Nanoplastics (NPs) with a size of less than 1 µm have received worldwide attention as an emerging environmental pollutant. Because they are easier for organisms to absorb, they pose higher ecological and health risks than microplastics. Natural water is a significant source of nanoplastics in the environment, and it is important for both human and ecosystem health. The analysis of nanoplastics in waters is still lacking reliable and harmonized methods. Most of the studies successfully identified and removed standard reference nanoplastics from environmental samples, but they were unable to quantify nanoplastics from real field samples. Here, we reviewed studies that measured and removed nanoplastics in environmental waters, such as seawater, rivers, drinking water, wastewater, snow, and so on. Pyrolysis gas chromatography–mass spectrometry (py-GC–MS) and surface-enhanced Raman spectroscopy were two common methods for analyzing nanoplastics in real samples. Mass spectrometry methods are time-consuming and cannot analyze the full nanorange due to particle size restrictions. This approach for measuring nanoplastic mass concentration may involve mistakes and require larger sample quantities. Various strategies for removing nanoplastics, including centrifugation, coagulation, filtration, flocculation, and adsorption, were reviewed. The effectiveness of nanoplastic removal is influenced by parameters such as source, size, type, and purification process. The removal efficiency for nanoplastics is 99 % when combined with filtration and coagulation processes. This study provides basic information for future research on the analysis and removal of nanoplastics from water and wastewater.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111884"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in sampling and sorbent-based sample preparation procedures for bioanalytical applications","authors":"Marcello Locatelli ,&nbsp;Abuzar Kabir ,&nbsp;Miryam Perrucci ,&nbsp;Halil Ibrahim Ulusoy ,&nbsp;Songül Ulusoy ,&nbsp;Natalia Manousi ,&nbsp;Victoria Samanidou ,&nbsp;Imran Ali ,&nbsp;Sariye Irem Kaya ,&nbsp;Fotouh R. Mansour ,&nbsp;Ahmet Cetinkaya ,&nbsp;Sibel A. Ozkan","doi":"10.1016/j.microc.2024.111903","DOIUrl":"10.1016/j.microc.2024.111903","url":null,"abstract":"<div><div>In the last century, in the analytical field, the interest of researchers in the preliminary phases of the analysis has grown more and more, giving space to important innovations in the field of sample preparation, but above all leading to a renewed interest in this field. It is known that these phases are the most critical of the entire analytical process not only in terms of time, but also in terms of final measurement error. In this perspective, in recent years a growing interest of the Scientific Community and important efforts have been directed towards not only the development of innovative techniques that allow a reduction in sample manipulation while maintaining high analytical performance, but at the same time also towards a reduction in the environmental impact that such procedures can have. In this direction, there is also the possibility of intervening to reduce the quantity of sample processed and, consequently, obtain a reduction in the volumes of solvents and non-green reagents.</div><div>The main objective of this review is to provide an overview of the literature focused on the most modern sorbent-based sampling and sample preparation techniques that are applied (or have been recently developed) in the three main “sections” of instrumental analysis (sensor-based analysis, electrochemical analysis and chromatography-based analysis). In particular, the Authors wanted to outline the main advantages and disadvantages of the different procedures and above all evaluate how the different methods are applied in the field of biological matrix analysis (biological fluids, tissues, etc.). A final paragraph also considers an evaluation and estimate (using the most recent tools) for the environmental impact assessment and how they can be applied in this field (AGREE, AGREEprep, and MoGAPI). Through these applications it is also evaluated how continuous improvement is possible by checking the “critical” points and remedying/optimizing the procedures in this sense.</div><div>The present review finally concludes with a section on future perspectives in which the Authors (based on their vast experience in their respective fields of application) have tried to hypothesize a possible future and a possible way to be considered to ensure that this part of the analytical process can further progress and support the new challenges that daily arise in the field of bioanalytical applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111903"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing the potential of sniffing dogs and GC–MS in analyzing human urine: A comprehensive review of sample preparation and extraction techniques","authors":"Laetitia Maidodou ,&nbsp;Damien Steyer ,&nbsp;Marie-Anaïs Monat ,&nbsp;Michelle Leemans ,&nbsp;Isabelle Fromantin ,&nbsp;Eric Marchioni ,&nbsp;Igor Clarot","doi":"10.1016/j.microc.2024.111907","DOIUrl":"10.1016/j.microc.2024.111907","url":null,"abstract":"<div><div>Pathologies such as cancers or infectious diseases can induce modifications in the concentrations of urinary volatile metabolites. Indeed, urine is a large source of Volatile Organic Compounds (VOCs) from the human body. Canine olfaction and Gas Chromatography coupled to Mass Spectrometry (GC–MS) systems are promising tools for the development of non-invasive diagnosis methods based on the analysis of urine. This review paper aims to provide an overview of materials and methods found in the literature for urinary VOCs analysis by detection dogs and GC–MS instruments. It highlights the impact of urine collection procedures and storage conditions. Then, sample preparation protocols for canine olfaction are discussed, as well as for GC–MS analysis, focusing on headspace-based extraction techniques. In the case of instrumental analysis, a significant variability of volatile profiles can be observed depending on the sample preparation (urine pH, extraction methods), and analytical parameters. Lastly, limitations of urinary VOCs analysis for medical diagnosis purposes are considered.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111907"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances and principles of metal–organic framework for the detection of chloramphenicol: Perspectives and challenges","authors":"Miao Liu ,&nbsp;Kayhaneh Berijani ,&nbsp;Jiaxin Ma ,&nbsp;Sirui Guo ,&nbsp;Yanqiong Peng ,&nbsp;Ying Pan ,&nbsp;Ali Morsali ,&nbsp;Yong Huang","doi":"10.1016/j.microc.2024.111878","DOIUrl":"10.1016/j.microc.2024.111878","url":null,"abstract":"<div><div>According to the continuous development of today’s society, the production of environmental pollutants has been a severe concern observed in the drug industries. For instance, the demand for the consumption of antibiotics is one of them that is increasing, and the residual hazards of the broad-spectrum antibiotic chloramphenicol (CAP) are widespread, which can not only pollute the environment but can also have negative health impacts on humans. Thus, the detection of CAP is of great significance. Among the used chemical materials to solve this issue, the essential metal–organic skeletons, namely metal–organic frameworks (MOFs) have promising applications due to their advantages such as large specific surface area (SA), abundant pores, and luminescent properties. This paper describes the principles of electrochemical, fluorescent, and probe assays related to the detection of CAP. A more comprehensive overview of the use of MOFs for the detection of CAP and other antibiotics in water and food and how CAP can be monitored with high sensitivity, high selectivity, and stability in the form of various sensors is given, as well as future perspectives on MOFs materials that have the potential to be used as sensors.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111878"},"PeriodicalIF":4.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}