Microchemical Journal最新文献_第4页

Emerging trends: Smartphone-assisted aptasensors enabling detection of pathogen and chemical contamination 新趋势：能检测病原体和化学污染的智能手机辅助灵敏传感器

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-10-01 DOI: 10.1016/j.microc.2024.111736

Priyanka Garg , Ritika Gupta , Nitesh Priyadarshi , Poonam Sagar , Vishakha Bisht , Naveen K. Navani , Nitin Kumar Singhal

The timely and rapid detection of pathogens and environmental contaminants is critical in safeguarding human health and preventing crises. Pathogens, antibiotic residues, pesticides, and heavy metals pose significant threats to human lives and the economy due to their rapid spread. Developing effective methods for detecting and preventing contaminant spread remains a major challenge. Researchers have been exploring innovative sensing approaches to enable easy, portable, and cost-effective detection using smartphones as versatile sensing tools in recent years. Integrating smartphones with detection assays allows for convenient result acquisition through a simple photograph. Aptamers, with their high affinity and selectivity, have gained substantial interest in biosensing, and they are increasingly employed in the design of novel detection assays based on optical or electrochemical principles. Additionally, smartphone applications can be developed to process images and analyze results based on optical or electrochemical signals, accurately determining pathogen loads. Apart from aptamers, smartphone-based detection platforms also utilize other sensing elements, such as antibodies, carbohydrates, and proteins. Coupling smartphones with detection assays simplifies the detection procedure, making it portable and highly sensitive. This review focuses on the latest technological advancements in smartphone-based devices for biosensing applications, highlighting their potential for rapid pathogen and contaminant detection.

及时、快速地检测病原体和环境污染物对于保障人类健康和预防危机至关重要。病原体、抗生素残留、杀虫剂和重金属因其快速传播而对人类生命和经济构成重大威胁。开发检测和防止污染物扩散的有效方法仍然是一项重大挑战。近年来，研究人员一直在探索创新的传感方法，利用智能手机作为多功能传感工具，实现简便、便携、经济高效的检测。将智能手机与检测方法相结合，只需简单拍照就能方便地获取结果。具有高亲和力和高选择性的 Aptamers 已在生物传感领域受到广泛关注，并越来越多地被用于设计基于光学或电化学原理的新型检测方法。此外，还可以开发智能手机应用程序，根据光学或电化学信号处理图像和分析结果，准确确定病原体的负荷。除适配体外，基于智能手机的检测平台还可利用其他传感元件，如抗体、碳水化合物和蛋白质。将智能手机与检测化验相结合，简化了检测程序，使其便携、灵敏度高。本综述重点介绍基于智能手机的生物传感应用设备的最新技术进展，突出其在病原体和污染物快速检测方面的潜力。

{"title":"Emerging trends: Smartphone-assisted aptasensors enabling detection of pathogen and chemical contamination","authors":"Priyanka Garg , Ritika Gupta , Nitesh Priyadarshi , Poonam Sagar , Vishakha Bisht , Naveen K. Navani , Nitin Kumar Singhal","doi":"10.1016/j.microc.2024.111736","DOIUrl":"10.1016/j.microc.2024.111736","url":null,"abstract":"<div><div>The timely and rapid detection of pathogens and environmental contaminants is critical in safeguarding human health and preventing crises. Pathogens, antibiotic residues, pesticides, and heavy metals pose significant threats to human lives and the economy due to their rapid spread. Developing effective methods for detecting and preventing contaminant spread remains a major challenge. Researchers have been exploring innovative sensing approaches to enable easy, portable, and cost-effective detection using smartphones as versatile sensing tools in recent years. Integrating smartphones with detection assays allows for convenient result acquisition through a simple photograph. Aptamers, with their high affinity and selectivity, have gained substantial interest in biosensing, and they are increasingly employed in the design of novel detection assays based on optical or electrochemical principles. Additionally, smartphone applications can be developed to process images and analyze results based on optical or electrochemical signals, accurately determining pathogen loads. Apart from aptamers, smartphone-based detection platforms also utilize other sensing elements, such as antibodies, carbohydrates, and proteins. Coupling smartphones with detection assays simplifies the detection procedure, making it portable and highly sensitive. This review focuses on the latest technological advancements in smartphone-based devices for biosensing applications, highlighting their potential for rapid pathogen and contaminant detection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111736"},"PeriodicalIF":4.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review of state-of-the-art biosensors for detection of allergenic substance lysozyme: A structured recent review and update 用于检测致敏物质溶菌酶的最先进生物传感器综述：近期结构性综述与更新

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-30 DOI: 10.1016/j.microc.2024.111805

Alireza Ebrahimi , Reza Abedi-Firoozjah , Ali Ehsani , Hamed Hamishehkar , Milad Tavassoli

Lysozyme (LZM) is a major allergenic protein found in different foods, such as chicken eggs, primarily in the egg white. It can cause adverse reactions in sensitive individuals, leading to symptoms ranging from mild hives to life-threatening anaphylactic shock. Therefore, it’s crucial for those with allergies to avoid any contact with LZM and foods containing it. Reliable analytical methods are essential to ensure consumer safety and improve food production through hazard analysis and good manufacturing practices. The following review article provides an overview of recent progress in biosensors used for the detection of LZM. This article developed a comprehensive review of the main applications of LZM detection, emphasizing the advantages and disadvantages of common analytical techniques such as conventional methods (DNA-based methods and ELISA/Immunochromatography assay/Immunoassay/Mass spectrometry) and modern methods (biosensors such as electrochemical, optical, molecularly imprinted polymers and magnetoelastic sensing). Subsequently, it delves into the developments in biosensors pertaining to the detection mechanisms, including the utilization of nanomaterials as signal probes and carriers for loading signal probes, while also addressing their sensitivity and performance evaluation. Lastly, it discusses the challenges and potential opportunities in the advancement of biosensors for LZM detection.

溶菌酶（LZM）是一种主要的过敏原蛋白质，存在于鸡肉鸡蛋等不同食物中，主要存在于蛋白中。它可引起敏感人群的不良反应，导致轻度荨麻疹到危及生命的过敏性休克等症状。因此，对于过敏体质的人来说，避免接触 LZM 和含有 LZM 的食物至关重要。可靠的分析方法对于确保消费者安全以及通过危害分析和良好生产规范改进食品生产至关重要。以下综述文章概述了用于检测 LZM 的生物传感器的最新进展。本文全面综述了 LZM 检测的主要应用，强调了常见分析技术的优缺点，如传统方法（基于 DNA 的方法和酶联免疫吸附法/免疫层析法/免疫测定/质谱法）和现代方法（生物传感器，如电化学、光学、分子印迹聚合物和磁弹性传感）。随后，报告深入探讨了生物传感器在检测机制方面的发展，包括利用纳米材料作为信号探针和载入信号探针的载体，同时还讨论了其灵敏度和性能评估。最后，报告还讨论了用于 LZM 检测的生物传感器在发展过程中面临的挑战和潜在机遇。

{"title":"A comprehensive review of state-of-the-art biosensors for detection of allergenic substance lysozyme: A structured recent review and update","authors":"Alireza Ebrahimi , Reza Abedi-Firoozjah , Ali Ehsani , Hamed Hamishehkar , Milad Tavassoli","doi":"10.1016/j.microc.2024.111805","DOIUrl":"10.1016/j.microc.2024.111805","url":null,"abstract":"<div><div>Lysozyme (LZM) is a major allergenic protein found in different foods, such as chicken eggs, primarily in the egg white. It can cause adverse reactions in sensitive individuals, leading to symptoms ranging from mild hives to life-threatening anaphylactic shock. Therefore, it’s crucial for those with allergies to avoid any contact with LZM and foods containing it. Reliable analytical methods are essential to ensure consumer safety and improve food production through hazard analysis and good manufacturing practices. The following review article provides an overview of recent progress in biosensors used for the detection of LZM. This article developed a comprehensive review of the main applications of LZM detection, emphasizing the advantages and disadvantages of common analytical techniques such as conventional methods (DNA-based methods and ELISA/Immunochromatography assay/Immunoassay/Mass spectrometry) and modern methods (biosensors such as electrochemical, optical, molecularly imprinted polymers and magnetoelastic sensing). Subsequently, it delves into the developments in biosensors pertaining to the detection mechanisms, including the utilization of nanomaterials as signal probes and carriers for loading signal probes, while also addressing their sensitivity and performance evaluation. Lastly, it discusses the challenges and potential opportunities in the advancement of biosensors for LZM detection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111805"},"PeriodicalIF":4.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developments and trends in mycotoxin analysis: A review with bibliometric research 霉菌毒素分析的发展与趋势：文献计量学研究综述

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-27 DOI: 10.1016/j.microc.2024.111774

Chuang Wang , Ying Huang , YunYun Wang , Jing Zhang , MengYue Guo , ChangYong Chen , HuiRu Zhang , BinYang Yue , DanDan Kong , JiaoYang Luo , MeiHua Yang

Food safety is crucial for human health, and mycotoxins, produced by fungi, can contaminate food, posing a serious health threat. Understanding mycotoxin production, toxicity mechanisms, and accurate detection is essential for food safety. While many studies have explored these aspects, there is still room for improvement in detection methods for mycotoxins. Taking mycotoxins as an entry point, this paper systematically collected and analyzed mycotoxin-related literatures from mainstream databases by combining bibliometric analysis, revealing the development trend and research focuses in this field, confirming mycotoxin detection methods as the core of this review, and further discussing chromatography-based, spectrometry-based, immunoassay-based, biosensor-based, and other. Research advances and limitations of mycotoxin detection methods, such as high sensitivity versus cumbersome processing for chromatography, low cost for spectroscopy, and high specificity for immunoassays, were further discussed. Emerging technologies like immunoassays and biosensors show promise for rapid and portable detection. Challenges in sample preparation and matrix effects are also discussed. Meanwhile, by analyzing the development trend of mycotoxin detection methods, it is predicted that the future research focus will be mainly on the two aspects of highly sensitive and accurate detection and rapid and accurate on-site detection. This review aims to provide insights for the field’s development, predict future trends in mycotoxin analysis, and enhance food safety and public health protection.

食品安全对人类健康至关重要，而真菌产生的霉菌毒素会污染食品，对健康构成严重威胁。了解霉菌毒素的产生、毒性机制和准确检测对食品安全至关重要。虽然已有许多研究对这些方面进行了探索，但霉菌毒素的检测方法仍有待改进。本文以霉菌毒素为切入点，结合文献计量学分析方法，系统地收集和分析了主流数据库中与霉菌毒素相关的文献，揭示了该领域的发展趋势和研究重点，确定了霉菌毒素检测方法作为本综述的核心内容，并进一步探讨了基于色谱法、基于光谱法、基于免疫测定法、基于生物传感器法和其他方法。还进一步讨论了霉菌毒素检测方法的研究进展和局限性，如色谱法的高灵敏度与繁琐的处理过程、光谱法的低成本、免疫测定法的高特异性等。免疫测定和生物传感器等新兴技术为快速和便携式检测带来了希望。此外，还讨论了样品制备和基质效应方面的挑战。同时，通过分析霉菌毒素检测方法的发展趋势，预测未来的研究重点将主要集中在高灵敏度和高准确度检测以及快速准确的现场检测两个方面。本综述旨在为该领域的发展提供启示，预测霉菌毒素分析的未来趋势，加强食品安全和公共卫生保护。

{"title":"Developments and trends in mycotoxin analysis: A review with bibliometric research","authors":"Chuang Wang , Ying Huang , YunYun Wang , Jing Zhang , MengYue Guo , ChangYong Chen , HuiRu Zhang , BinYang Yue , DanDan Kong , JiaoYang Luo , MeiHua Yang","doi":"10.1016/j.microc.2024.111774","DOIUrl":"10.1016/j.microc.2024.111774","url":null,"abstract":"<div><div>Food safety is crucial for human health, and mycotoxins, produced by fungi, can contaminate food, posing a serious health threat. Understanding mycotoxin production, toxicity mechanisms, and accurate detection is essential for food safety. While many studies have explored these aspects, there is still room for improvement in detection methods for mycotoxins. Taking mycotoxins as an entry point, this paper systematically collected and analyzed mycotoxin-related literatures from mainstream databases by combining bibliometric analysis, revealing the development trend and research focuses in this field, confirming mycotoxin detection methods as the core of this review, and further discussing chromatography-based, spectrometry-based, immunoassay-based, biosensor-based, and other. Research advances and limitations of mycotoxin detection methods, such as high sensitivity versus cumbersome processing for chromatography, low cost for spectroscopy, and high specificity for immunoassays, were further discussed. Emerging technologies like immunoassays and biosensors show promise for rapid and portable detection. Challenges in sample preparation and matrix effects are also discussed. Meanwhile, by analyzing the development trend of mycotoxin detection methods, it is predicted that the future research focus will be mainly on the two aspects of highly sensitive and accurate detection and rapid and accurate on-site detection. This review aims to provide insights for the field’s development, predict future trends in mycotoxin analysis, and enhance food safety and public health protection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111774"},"PeriodicalIF":4.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic profiling of plant and other natural products: Platforms, applications and quality evaluation 植物和其他天然产品的代谢分析：平台、应用和质量评估

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-26 DOI: 10.1016/j.microc.2024.111779

Adeyemi O. Adeeyo , Isaac O. Amao , Yvan A.T. Ngandjui , Mercy A. Alabi , Titus A.M. Msagati

This review unveils the possibility of metabolomics in natural product study and documents available techniques, strategies, and platforms for metabolite profiling. Metabolomics process flow including experimental designs, sample preparations, data acquisition, mining, and results interpretation are presented. The leveraging of metabolomics for maximizing natural product development and sustainable plant use was explored. The extensive review and presentation of details in metabolomics, lead medicine discoveries and frameworks for quality control, fill important research gaps and expand frontiers of knowledge within the field of study.

这篇综述揭示了代谢组学在天然产物研究中的可能性，并记录了现有的代谢物分析技术、策略和平台。文中介绍了代谢组学的流程，包括实验设计、样品制备、数据采集、挖掘和结果解读。还探讨了如何利用代谢组学最大限度地开发天然产品和实现植物的可持续利用。对代谢组学、先导药物发现和质量控制框架的详细介绍，填补了重要的研究空白，拓展了该研究领域的知识前沿。

引用次数: 0

An advanced early warning technology for coral bleaching crisis based on the electrochemical biosensing of coral-symbiotic zooxanthellae eDNA 基于珊瑚-共生贝藻 eDNA 电化学生物传感的珊瑚白化危机高级预警技术

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-26 DOI: 10.1016/j.microc.2024.111775

Chaoxin Zhang , Hongjie Liu , Shaopeng Wang , Man Zhang , Jiayuan Liang , Hao Fu , Yingmei Wei , Kefu Yu , Liwei Wang

The symbiotic zooxanthellae in corals are extremely sensitive to the marine environment, and corals bleach rapidly when the symbiotic zooxanthellae are detached from their coral hosts. Currently, ecological monitoring techniques face many problems in coral health assessment, especially coral reef destruction during sampling. In this paper, an electrochemical eDNA biosensor based on ECM/MoS₂ nanocomposites constructed with specific DNA probes was developed to detect the environmental DNA of free zooxanthellae at a low limit of detection (LOD = 0.223 pM) and limit of quantification (LOQ = 0.743 pM) under the experimentally optimized conditions, demonstrating excellent specificity and steadiness. Over and above, the electrochemical response of the biosensor to zooxanthellae DNA was significantly higher than that of other interferent targets, proving its high selectivity. On this basis, the dependability and precision of the biosensor were further verified by comparing the biosensor with ddPCR (P > 0.05, RSD < 5 %). Hence, this electrochemical biosensor can dynamically monitor community changes in zooxanthellae without destroying coral reefs and may serve as a non-invasive method for early warning of coral reef crises. The technique can also be upgraded with portable capabilities in future studies to provide greater convenience in the field analysis of coral bleaching.

珊瑚中的共生动物贝对海洋环境极为敏感，当共生动物贝脱离珊瑚宿主时，珊瑚会迅速漂白。目前，生态监测技术在珊瑚健康评估中面临诸多问题，尤其是采样过程中对珊瑚礁的破坏。本文基于 ECM/MoS2 纳米复合材料与特异性 DNA 探针构建了一种电化学 eDNA 生物传感器，在实验优化的条件下，以较低的检出限（LOD = 0.223 pM）和定量限（LOQ = 0.743 pM）检测环境中游离的动物贝类 DNA，表现出良好的特异性和稳定性。此外，该生物传感器对动物贝类 DNA 的电化学响应明显高于其他干扰目标，证明了其高选择性。在此基础上，生物传感器与 ddPCR 的比较进一步验证了生物传感器的可靠性和精确性（P > 0.05, RSD < 5 %）。因此，这种电化学生物传感器可以在不破坏珊瑚礁的情况下动态监测动物贝类群落的变化，可作为珊瑚礁危机预警的非侵入性方法。在未来的研究中，该技术还可以升级为便携式，为珊瑚白化的实地分析提供更大的便利。

{"title":"An advanced early warning technology for coral bleaching crisis based on the electrochemical biosensing of coral-symbiotic zooxanthellae eDNA","authors":"Chaoxin Zhang , Hongjie Liu , Shaopeng Wang , Man Zhang , Jiayuan Liang , Hao Fu , Yingmei Wei , Kefu Yu , Liwei Wang","doi":"10.1016/j.microc.2024.111775","DOIUrl":"10.1016/j.microc.2024.111775","url":null,"abstract":"<div><div>The symbiotic <em>zooxanthellae</em> in corals are extremely sensitive to the marine environment, and corals bleach rapidly when the symbiotic <em>zooxanthellae</em> are detached from their coral hosts. Currently, ecological monitoring techniques face many problems in coral health assessment, especially coral reef destruction during sampling. In this paper, an electrochemical eDNA biosensor based on ECM/MoS<sub>2</sub> nanocomposites constructed with specific DNA probes was developed to detect the environmental DNA of free <em>zooxanthellae</em> at a low limit of detection (LOD = 0.223 pM) and limit of quantification (LOQ = 0.743 pM) under the experimentally optimized conditions, demonstrating excellent specificity and steadiness. Over and above, the electrochemical response of the biosensor to <em>zooxanthellae</em> DNA was significantly higher than that of other interferent targets, proving its high selectivity. On this basis, the dependability and precision of the biosensor were further verified by comparing the biosensor with ddPCR (<em>P</em> > 0.05, RSD < 5 %). Hence, this electrochemical biosensor can dynamically monitor community changes in <em>zooxanthellae</em> without destroying coral reefs and may serve as a non-invasive method for early warning of coral reef crises. The technique can also be upgraded with portable capabilities in future studies to provide greater convenience in the field analysis of coral bleaching.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111775"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-mode colorimetric–fluorometric immunoassay for foodborne parasitic infection 食源性寄生虫感染的比色-荧光双模式免疫分析法

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-26 DOI: 10.1016/j.microc.2024.111778

Yao Yu , Xiaolei Liu , Ning Xu , Lin Li , Yaming Yang , Mingyuan Liu , Lianjing Zhao , Xue Bai

Immunoassays are the primary method used for detection of foodborne parasitic infection. The nanomaterials used in these assays often present challenges such as complex preparation requirements and low stability during long-term storage and transport. Herein, based on cost-effective K₃[Fe(CN)₆]-mediated in-situ generated CuFe Prussian blue analogues (CuFe-PBA) and quinoxaline derivatives with high fluorescence, a dual-mode immunoassay was proposed for foodborne parasitic infection. This platform is relied on the restoration of K₃[Fe(CN)₆] by ascorbic acid (AA). In addition to this process, K₄[Fe(CN)₆]-triggered the generation of CuFe-PBA, and the enhanced fluorogenic reaction of dehydrogenated AA and o-phenylenediamine (OPD) occur sequentially. Without complex probes preparation, the assay enabled the rapid on-site detection of ALP and foodborne parasitic infection through a colorimetric mode accessible via smartphone and offered enhanced sensitivity through a fluorescent mode. The method was used for the detection of ALP, achieving detection limits of 0.38 U/L and 0.03 U/L for colorimetric and fluorescence modes, respectively. Subsequently, the dual-mode immunoassay was applied to Trichinella spiralis infection. The sensitivity and specificity of both the colorimetric and fluorescence modes were 100 % in 950 pig serum samples. This immunosensor provides a universal analysis tool for the accurate, cost-effective and highly sensitive detection of foodborne parasitic infection.

免疫测定是检测食源性寄生虫感染的主要方法。这些检测中使用的纳米材料往往面临着制备要求复杂、长期储存和运输过程中稳定性低等挑战。在此，我们提出了一种基于高性价比的 K3[Fe(CN)6]介导的原位生成铜铁普鲁士蓝类似物（CuFe-PBA）和高荧光喹喔啉衍生物的食源性寄生虫感染双模式免疫测定方法。该平台依靠抗坏血酸（AA）恢复 K3[Fe(CN)6]。除此以外，K4[Fe(CN)6]还触发了 CuFe-PBA 的生成，脱氢 AA 和邻苯二胺（OPD）的强化荧光反应也相继发生。该检测方法无需制备复杂的探针，可通过智能手机的比色模式快速现场检测 ALP 和食源性寄生虫感染，并通过荧光模式提高灵敏度。该方法用于检测 ALP，比色和荧光模式的检测限分别为 0.38 U/L 和 0.03 U/L 。随后，将双模式免疫测定应用于螺旋毛霉感染的检测。在 950 份猪血清样本中，比色和荧光模式的灵敏度和特异性均为 100%。这种免疫传感器为准确、经济、高灵敏度地检测食源性寄生虫感染提供了一种通用分析工具。

{"title":"Dual-mode colorimetric–fluorometric immunoassay for foodborne parasitic infection","authors":"Yao Yu , Xiaolei Liu , Ning Xu , Lin Li , Yaming Yang , Mingyuan Liu , Lianjing Zhao , Xue Bai","doi":"10.1016/j.microc.2024.111778","DOIUrl":"10.1016/j.microc.2024.111778","url":null,"abstract":"<div><div>Immunoassays are the primary method used for detection of foodborne parasitic infection. The nanomaterials used in these assays often present challenges such as complex preparation requirements and low stability during long-term storage and transport. Herein, based on cost-effective K<sub>3</sub>[Fe(CN)<sub>6</sub>]-mediated in-situ generated CuFe Prussian blue analogues (CuFe-PBA) and quinoxaline derivatives with high fluorescence, a dual-mode immunoassay was proposed for foodborne parasitic infection. This platform is relied on the restoration of K<sub>3</sub>[Fe(CN)<sub>6</sub>] by ascorbic acid (AA). In addition to this process, K<sub>4</sub>[Fe(CN)<sub>6</sub>]-triggered the generation of CuFe-PBA, and the enhanced fluorogenic reaction of dehydrogenated AA and <em>o</em>-phenylenediamine (OPD) occur sequentially. Without complex probes preparation, the assay enabled the rapid on-site detection of ALP and foodborne parasitic infection through a colorimetric mode accessible via smartphone and offered enhanced sensitivity through a fluorescent mode. The method was used for the detection of ALP, achieving detection limits of 0.38 U/L and 0.03 U/L for colorimetric and fluorescence modes, respectively. Subsequently, the dual-mode immunoassay was applied to <em>Trichinella spiralis</em> infection. The sensitivity and specificity of both the colorimetric and fluorescence modes were 100 % in 950 pig serum samples. This immunosensor provides a universal analysis tool for the accurate, cost-effective and highly sensitive detection of foodborne parasitic infection.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111778"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination aquaphotomics study and LF-NMR to monitor the drying process of honey pills 结合水生生物组学研究和 LF-NMR 监测蜜丸的干燥过程

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-26 DOI: 10.1016/j.microc.2024.111772

Mengyin Tian , Xiaobo Ma , Lian Li , Aoli Wu , Xue Gao , Zhaoqing Meng , Guiyun Cao , Yi Luo , Lei Nie , Hengchang Zang

As one of the factors affecting the quality of honey pills (HP), there are few researches on its quality control and solutions. But water can directly affect the appearance, stability and potency of the HP. In this study, near-infrared spectroscopy was used to monitor the moisture content of HP with different drying conditions, and multiple linear regression analysis was carried out to establish the moisture content prediction model, and the R² of the model prediction is 0.9532. The visualization of HP drying process were carried out by aquaphotomics method characterizes the status of the water molecular network at different drying stages. At the same time, low-field nuclear magnetic resonance (LF-NMR) information was carried out to analyze the water distribution in the drying process, and further verified the water solvent shell action in the water balance process of aquaphotomics analysis. The surface water of the pill disperses to the air, and the internal water diffuses outwards. We adopted the techniques such as rheology to comprehensively characterize the state of HP, and to evaluate the quality of them by using the dissolution test. The quality state of the pills was analyzed by the aquaphotomics analysis of water species. The above research system provided the scientific basis for revealing the drying process of HP from the viewpoint of aquaphotomics, as well as showed potential for expansion and application to other Chinese traditional medicine products.

作为影响蜜丸（HP）质量的因素之一，有关其质量控制和解决方案的研究很少。但水分会直接影响蜜丸的外观、稳定性和药效。本研究采用近红外光谱法监测不同干燥条件下蜂蜜丸的含水量，并通过多元线性回归分析建立含水量预测模型，模型预测的 R2 为 0.9532。通过水相组学方法表征了不同干燥阶段水分子网络的状态，从而实现了惠普干燥过程的可视化。同时，通过低场核磁共振（LF-NMR）信息分析了干燥过程中的水分分布，进一步验证了水相组学分析的水分平衡过程中水溶剂壳的作用。药丸表面的水分散到空气中，内部的水向外扩散。我们采用流变学等技术来综合表征 HP 的状态，并通过溶出试验来评价其质量。通过水体物种组学分析，对药丸的质量状态进行了分析。上述研究体系为从水体组学的角度揭示牛黄的干燥过程提供了科学依据，同时也显示了在其他中药产品中推广应用的潜力。

{"title":"Combination aquaphotomics study and LF-NMR to monitor the drying process of honey pills","authors":"Mengyin Tian , Xiaobo Ma , Lian Li , Aoli Wu , Xue Gao , Zhaoqing Meng , Guiyun Cao , Yi Luo , Lei Nie , Hengchang Zang","doi":"10.1016/j.microc.2024.111772","DOIUrl":"10.1016/j.microc.2024.111772","url":null,"abstract":"<div><div>As one of the factors affecting the quality of honey pills (HP), there are few researches on its quality control and solutions. But water can directly affect the appearance, stability and potency of the HP. In this study, near-infrared spectroscopy was used to monitor the moisture content of HP with different drying conditions, and multiple linear regression analysis was carried out to establish the moisture content prediction model, and the R<sup>2</sup> of the model prediction is 0.9532. The visualization of HP drying process were carried out by aquaphotomics method characterizes the status of the water molecular network at different drying stages. At the same time, low-field nuclear magnetic resonance (LF-NMR) information was carried out to analyze the water distribution in the drying process, and further verified the water solvent shell action in the water balance process of aquaphotomics analysis. The surface water of the pill disperses to the air, and the internal water diffuses outwards. We adopted the techniques such as rheology to comprehensively characterize the state of HP, and to evaluate the quality of them by using the dissolution test. The quality state of the pills was analyzed by the aquaphotomics analysis of water species. The above research system provided the scientific basis for revealing the drying process of HP from the viewpoint of aquaphotomics, as well as showed potential for expansion and application to other Chinese traditional medicine products.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111772"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH sensitive indicator film based intelligent packaging systems of perishables: Developments and challenges of last decade 基于 pH 值敏感指示膜的易腐食品智能包装系统：过去十年的发展与挑战

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-26 DOI: 10.1016/j.microc.2024.111732

Anika Panwar , Satish Kumar , Atul Dhiman , Vikas Kumar , Dharmesh Gupta , Ajay Sharma

Consumers’ demand for novel and non-destructive systems to assess food freshness in real time has led to the development of halochromic or pH-sensitive dyes based freshness indicators (FI) as affordable technique for intelligent monitoring of perishable food. However, the genuine concern regarding the toxicity and deleterious health effect of incorporating conventional synthetic dyes in commercially available halochromic freshness indicators (i.e. fresh tag, checkpoint, and sensorQ) and their sole purpose of monitoring the freshness status of muscle foods (i.e. fish, meat, beef, and shrimp) have led to the revolutionary idea of developing a non-toxic, chemical-free, and sustainable FI based on natural pH-sensitive dyes and polymer matrix. This review delves into significant advances in the chemistry, composition, production, food interaction, stabilization and broad applications of pH-sensitive dyes in the food sector. Unfortunately, the pH-sensitive dyes have reported limited applications in fresh fruit and vegetable industry due to challenges like erratic fluctuations in pH as influenced by factors i.e. high respiration, faster ripening, and environmental changes, inability to distinguish ripening from spoilage, and complex standardization process for specific commodities. These issues merit the demand for further investigations to ensure the utilization of these smart monitoring systems in the modern industry for perishables. The use of FI can potentially play a significant role in reforming food industry, enhance consumer safety, reduce the risk of foodborne illnesses, and aid in the development of a more efficient and sustainable food supply system. Exploration of new natural ingredients and high sensitivity indicators for both animal and plant food products shall drive the innovations in FI for the food industry.

消费者对实时评估食品新鲜度的非破坏性新系统的需求促使人们开发了基于卤变色或 pH 敏感染料的新鲜度指示器（FI），作为对易腐食品进行智能监测的经济实惠的技术。然而，市场上现有的卤代新鲜度指示器（即新鲜标签、检查点和传感器Q）中使用的传统合成染料的毒性和对健康的有害影响，以及它们监测肌肉食品（即鱼、肉、牛肉和虾）新鲜度状态的唯一目的，引发了人们对开发基于天然 pH 值敏感染料和聚合物基质的无毒、无化学物质和可持续新鲜度指示器的革命性想法的真正担忧。本综述深入探讨了 pH 值敏感染料在化学、组成、生产、食品相互作用、稳定以及在食品领域的广泛应用等方面取得的重大进展。遗憾的是，pH 值敏感型染料在新鲜水果和蔬菜行业中的应用有限，这是因为存在一些挑战，如受高呼吸作用、快速成熟和环境变化等因素的影响，pH 值波动不稳定，无法区分成熟和变质，以及针对特定商品的复杂标准化过程。这些问题都需要进一步研究，以确保在现代易腐食品工业中使用这些智能监测系统。使用 FI 有可能在食品工业改革、提高消费者安全、降低食源性疾病风险方面发挥重要作用，并有助于发展更高效、更可持续的食品供应系统。探索新的天然成分和动植物食品的高灵敏度指标，将推动食品工业在食品成分分析方面的创新。

{"title":"pH sensitive indicator film based intelligent packaging systems of perishables: Developments and challenges of last decade","authors":"Anika Panwar , Satish Kumar , Atul Dhiman , Vikas Kumar , Dharmesh Gupta , Ajay Sharma","doi":"10.1016/j.microc.2024.111732","DOIUrl":"10.1016/j.microc.2024.111732","url":null,"abstract":"<div><div>Consumers’ demand for novel and non-destructive systems to assess food freshness in real time has led to the development of halochromic or pH-sensitive dyes based freshness indicators (FI) as affordable technique for intelligent monitoring of perishable food. However, the genuine concern regarding the toxicity and deleterious health effect of incorporating conventional synthetic dyes in commercially available halochromic freshness indicators (i.e. fresh tag, checkpoint, and sensorQ) and their sole purpose of monitoring the freshness status of muscle foods (i.e. fish, meat, beef, and shrimp) have led to the revolutionary idea of developing a non-toxic, chemical-free, and sustainable FI based on natural pH-sensitive dyes and polymer matrix. This review delves into significant advances in the chemistry, composition, production, food interaction, stabilization and broad applications of pH-sensitive dyes in the food sector. Unfortunately, the pH-sensitive dyes have reported limited applications in fresh fruit and vegetable industry due to challenges like erratic fluctuations in pH as influenced by factors i.e. high respiration, faster ripening, and environmental changes, inability to distinguish ripening from spoilage, and complex standardization process for specific commodities. These issues merit the demand for further investigations to ensure the utilization of these smart monitoring systems in the modern industry for perishables. The use of FI can potentially play a significant role in reforming food industry, enhance consumer safety, reduce the risk of foodborne illnesses, and aid in the development of a more efficient and sustainable food supply system. Exploration of new natural ingredients and high sensitivity indicators for both animal and plant food products shall drive the innovations in FI for the food industry.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111732"},"PeriodicalIF":4.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorine and boron co doped porous carbon materials as an electrochemical platform in trace-level sodium nitrite sensing 氟和硼共掺杂多孔碳材料作为痕量亚硝酸钠传感的电化学平台

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-25 DOI: 10.1016/j.microc.2024.111769

Nuerbiya Yalikun, Hongzhou gong, Chaofan Liu, Yingshuang Zhang

Sodium nitrite (NaNO₂) is a common chemical oilfield tracer in the field of reservoir geological analysis. A simple, sensitive, and accurate electrochemical detection method for detection of NaNO₂ has been studied. The electrode carbon porous material was based on coal tar pitch n-pentane insoluble extractants (CTPNI) and doped with the elements of fluorine (F) and boron (B) and labeled as FB-CTPNI-PC and an electrochemical sensor modified with FB-CTPNI-PC material was constructed for rapid detection of NaNO₂. The characterization results of SEM and TEM indicate that this material has certain number of pore structures, also the BET analysis showed that has main pore size distribution is around the range of 2–20 nm, with abundant mesoporous structure. Moreover, the modified electrode has a good electrocatalytic effect on NaNO₂. The electrochemical reaction mechanism of NaNO₂ on the surface of the modified electrode was a diffusion-controlled process involving protons. The detection range of NaNO₂ can reach 0.1 mM–9.5 mM. When the S/N is 3, the sensitivity is 219.8592 A·L·cm²·mol⁻¹ and the detection limit (LOD) is 0.011 μM. The constructed electrochemical sensor has been applied to the rapid detection of NaNO₂ in real oilfield water, with recovery rates ranging from 99.7 % to 103.4 %. It is also roughly consistent with the results of ion chromatography (IC) in detecting NaNO₂ in oilfield water, indicating that the sensor has high accuracy. This has provided a new prospect for oil filed tracer and detection technologies.

亚硝酸钠（NaNO2）是油藏地质分析领域常见的油田化学示踪剂。研究了一种简单、灵敏、准确的电化学检测方法来检测 NaNO2。以煤沥青正戊烷不溶性萃取剂（CTPNI）为基础，掺杂氟（F）和硼（B）元素的电极碳多孔材料被标记为 FB-CTPNI-PC，用 FB-CTPNI-PC 材料修饰的电化学传感器被构建用于快速检测 NaNO2。SEM 和 TEM 表征结果表明，该材料具有一定数量的孔结构，BET 分析表明其主要孔径分布在 2-20 nm 左右，具有丰富的介孔结构。此外，改性电极对 NaNO2 具有良好的电催化效果。NaNO2 在改性电极表面的电化学反应机理是一个涉及质子的扩散控制过程。NaNO2 的检测范围可达 0.1 mM-9.5 mM。当信噪比为 3 时，灵敏度为 219.8592 A-L-cm2-mol-1，检测限（LOD）为 0.011 μM。所构建的电化学传感器已应用于实际油田水中 NaNO2 的快速检测，回收率从 99.7 % 到 103.4 % 不等。在油田水中检测 NaNO2 的结果也与离子色谱法（IC）基本一致，表明该传感器具有很高的准确性。这为滤油示踪和检测技术提供了新的前景。

{"title":"Fluorine and boron co doped porous carbon materials as an electrochemical platform in trace-level sodium nitrite sensing","authors":"Nuerbiya Yalikun, Hongzhou gong, Chaofan Liu, Yingshuang Zhang","doi":"10.1016/j.microc.2024.111769","DOIUrl":"10.1016/j.microc.2024.111769","url":null,"abstract":"<div><div>Sodium nitrite (NaNO<sub>2</sub>) is a common chemical oilfield tracer in the field of reservoir geological analysis. A simple, sensitive, and accurate electrochemical detection method for detection of NaNO<sub>2</sub> has been studied. The electrode carbon porous material was based on coal tar pitch n-pentane insoluble extractants (CTPNI) and doped with the elements of fluorine (F) and boron (B) and labeled as FB-CTPNI-PC and an electrochemical sensor modified with FB-CTPNI-PC material was constructed for rapid detection of NaNO<sub>2</sub>. The characterization results of SEM and TEM indicate that this material has certain number of pore structures, also the BET analysis showed that has main pore size distribution is around the range of 2–20 nm, with abundant mesoporous structure. Moreover, the modified electrode has a good electrocatalytic effect on NaNO<sub>2</sub>. The electrochemical reaction mechanism of NaNO<sub>2</sub> on the surface of the modified electrode was a diffusion-controlled process involving protons. The detection range of NaNO<sub>2</sub> can reach 0.1 mM–9.5 mM. When the S/N is 3, the sensitivity is 219.8592 A·L·cm<sup>2</sup>·mol<sup>−1</sup> and the detection limit (LOD) is 0.011 μM. The constructed electrochemical sensor has been applied to the rapid detection of NaNO<sub>2</sub> in real oilfield water, with recovery rates ranging from 99.7 % to 103.4 %. It is also roughly consistent with the results of ion chromatography (IC) in detecting NaNO<sub>2</sub> in oilfield water, indicating that the sensor has high accuracy. This has provided a new prospect for oil filed tracer and detection technologies.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111769"},"PeriodicalIF":4.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Fourier infrared spectroscopy for noninvasive diagnosis of diabetes mellitus: Analysis and prospects for application based on blood, urine and saliva samples 用于糖尿病无创诊断的傅立叶红外光谱技术的进展：基于血液、尿液和唾液样本的分析与应用前景

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal

Pub Date : 2024-09-24 DOI: 10.1016/j.microc.2024.111764

Jing Yin , Guangwei Wang , Xianwen Zhang , Zhushanying Zhang , Yuan Gao , Wenchao Pan , Huimin Cao

Diabetes, a prevalent metabolic disorder, is typically diagnosed through the analysis of blood samples. Biochemical assays predicated on blood analysis, while affording a high degree of accuracy, inherently involve an invasive procedure and present logistical inconveniences for patients, thereby necessitating the exploration of alternative diagnostic modalities. In recent years, Fourier transform infrared spectroscopy (FTIR) has emerged as a promising tool for the rapid, sensitive, cost-effective, and non-invasive investigation of diagnostic modalities for diabetes mellitus, offering a novel avenue for advancing diabetes management strategies. This review offers a comprehensive summary of the current research landscape in recent years, focusing on the application of FTIR analysis for the detection of biological body fluids in the context of diabetes diagnosis. It encompasses an introductory overview of the research methodology employed for diagnosing diabetes through the analysis of three distinct body fluids, along with a forward-looking perspective on its potential implications and applications. The review commences with a comprehensive overview of the introduction and utilization of blood, urine, and saliva samples in the context of diabetes research. A meticulous comparison of existing research findings underscores the efficacy of Fourier Transform Infrared (FTIR) spectroscopy as a discriminating tool for differentiating body fluid samples derived from diabetic patients and those from healthy individuals. This advanced technique exhibits remarkable capability in identifying and distinguishing among diabetic patients by precisely quantifying the intensity and frequency of characteristic spectral peaks corresponding to specific biochemical components present within body fluids. FTIR spectroscopy holds promising clinical applications for diabetes diagnosis in body fluids, aiming to enable early detection and non-invasive monitoring via rapid biomarker identification.

糖尿病是一种常见的代谢性疾病，通常通过分析血液样本来诊断。以血液分析为基础的生化检测虽然具有很高的准确性，但其本身涉及侵入性程序，给患者带来后勤方面的不便，因此有必要探索其他诊断方式。近年来，傅立叶变换红外光谱（FTIR）已成为一种快速、灵敏、经济、无创的糖尿病诊断方法，为推进糖尿病管理策略提供了一条新途径。本综述全面总结了近年来的研究现状，重点介绍了在糖尿病诊断中应用傅立叶变换红外分析检测生物体液的情况。综述介绍了通过分析三种不同体液诊断糖尿病的研究方法，并对其潜在影响和应用进行了前瞻性展望。综述首先全面概述了在糖尿病研究中引入和使用血液、尿液和唾液样本的情况。通过对现有研究成果的细致比较，强调了傅立叶变换红外（FTIR）光谱作为一种鉴别工具在区分糖尿病患者和健康人体液样本方面的功效。这种先进的技术通过精确量化与体液中特定生化成分相对应的特征光谱峰的强度和频率，在识别和区分糖尿病患者方面表现出卓越的能力。傅立叶变换红外光谱技术在体液中诊断糖尿病方面具有广阔的临床应用前景，其目的是通过快速生物标记物鉴定实现早期检测和无创监测。

{"title":"Advances in Fourier infrared spectroscopy for noninvasive diagnosis of diabetes mellitus: Analysis and prospects for application based on blood, urine and saliva samples","authors":"Jing Yin , Guangwei Wang , Xianwen Zhang , Zhushanying Zhang , Yuan Gao , Wenchao Pan , Huimin Cao","doi":"10.1016/j.microc.2024.111764","DOIUrl":"10.1016/j.microc.2024.111764","url":null,"abstract":"<div><div>Diabetes, a prevalent metabolic disorder, is typically diagnosed through the analysis of blood samples. Biochemical assays predicated on blood analysis, while affording a high degree of accuracy, inherently involve an invasive procedure and present logistical inconveniences for patients, thereby necessitating the exploration of alternative diagnostic modalities. In recent years, Fourier transform infrared spectroscopy (FTIR) has emerged as a promising tool for the rapid, sensitive, cost-effective, and non-invasive investigation of diagnostic modalities for diabetes mellitus, offering a novel avenue for advancing diabetes management strategies. This review offers a comprehensive summary of the current research landscape in recent years, focusing on the application of FTIR analysis for the detection of biological body fluids in the context of diabetes diagnosis. It encompasses an introductory overview of the research methodology employed for diagnosing diabetes through the analysis of three distinct body fluids, along with a forward-looking perspective on its potential implications and applications. The review commences with a comprehensive overview of the introduction and utilization of blood, urine, and saliva samples in the context of diabetes research. A meticulous comparison of existing research findings underscores the efficacy of Fourier Transform Infrared (FTIR) spectroscopy as a discriminating tool for differentiating body fluid samples derived from diabetic patients and those from healthy individuals. This advanced technique exhibits remarkable capability in identifying and distinguishing among diabetic patients by precisely quantifying the intensity and frequency of characteristic spectral peaks corresponding to specific biochemical components present within body fluids. FTIR spectroscopy holds promising clinical applications for diabetes diagnosis in body fluids, aiming to enable early detection and non-invasive monitoring via rapid biomarker identification.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111764"},"PeriodicalIF":4.9,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0