The connecting peptide (C-peptide) is a short polypeptide that connects the A-chain to the B-chain in the proinsulin molecule. This biomarker is secreted into the blood circulation in the same amount as insulin and has a longer half-life than it. Measuring blood serum levels of C-peptide can be used to distinguish between different diabetes types. Also, the amount of C-peptide in body fluids as an indicator has been used to evaluate pancreatic beta‐cell function. However, a reliable and fast method is essential to quantify the amount of C-peptide in biological fluids and its significance in the control and diagnosis of disease. Over the years, several studies have used biosensors to detect C-peptide levels in real samples. These studies focused on speeding up detection and creating novel detection techniques. Biosensor-based methods can potentially improve the diagnosis and monitoring of diabetes. This review aims to provide a general overview of the various C-peptide biosensors in relation to their detection limit and potential point-of-care uses.
连接肽（C-肽）是连接胰岛素分子中 A 链和 B 链的短多肽。这种生物标志物分泌到血液循环中的量与胰岛素相同，但半衰期比胰岛素长。测量血清中的 C 肽水平可用于区分不同的糖尿病类型。此外，体液中的 C 肽含量也被用作评估胰岛β细胞功能的指标。然而，要量化生物体液中的 C 肽含量及其在疾病控制和诊断中的意义，必须要有一种可靠而快速的方法。多年来，已有多项研究使用生物传感器检测真实样本中的 C 肽水平。这些研究的重点是加快检测速度和开发新型检测技术。基于生物传感器的方法有可能改善糖尿病的诊断和监测。本综述旨在概述各种 C 肽生物传感器的检测极限和潜在的护理点用途。
{"title":"Detecting C-peptide using biosensors for diagnosis and monitoring of disease","authors":"Zahra Jamalizadeh Bahaabadi , Prashant Kesharwani , Amirhossein Sahebkar","doi":"10.1016/j.microc.2024.111922","DOIUrl":"10.1016/j.microc.2024.111922","url":null,"abstract":"<div><div>The connecting peptide (C-peptide) is a short polypeptide that connects the A-chain to the B-chain in the proinsulin molecule. This biomarker is secreted into the blood circulation in the same amount as insulin and has a longer half-life than it. Measuring blood serum levels of C-peptide can be used to distinguish between different diabetes types. Also, the amount of C-peptide in body fluids as an indicator has been used to evaluate pancreatic beta‐cell function. However, a reliable and fast method is essential to quantify the amount of C-peptide in biological fluids and its significance in the control and diagnosis of disease. Over the years, several studies have used biosensors to detect C-peptide levels in real samples. These studies focused on speeding up detection and creating novel detection techniques. Biosensor-based methods can potentially improve the diagnosis and monitoring of diabetes. This review aims to provide a general overview of the various C-peptide biosensors in relation to their detection limit and potential point-of-care uses.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111922"},"PeriodicalIF":4.9,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The spread of pathogenic bacteria in the environment, as a significant global issue, causes a substantial threat to human health, damaging economic development. Indeed, the development of sensitive and selective sensing approaches for detection of pathogenic bacteria is essential to prevent and treating infections. In this regard, biosensors as efficient analytical methods can play an important role. Importantly, exploiting of novel strategy can improve the performance of these biosensing platforms. Among different types, molecularly imprinted polymers (MIPs), as artificial receptors, that are developed to selective and sensitive biosensors. The distinct complementary cavities in these synthetic polymers contribute to their unique characteristics, as they are specifically tailored to their respective templates. Notably, bacteria-imprinted polymers (BIPs), as an important and novel member of MIPs, attracted considerable attention for different bacteria detection due to many cavities complementary to their bacteria. These novel probes can efficiently isolate various bacteria from wide range of samples such as food, water, or biological fluids due to the high affinity and selectivity. In this study, the application of BIPs in the structure of biosensors, as active area of research in the field of different bacteria detection, was reviewed for detection of Staphylococcus aureus (S. aureus), Salmonella, Vibrio parahaemolyticus ((V. parahaemolyticus) and Escherichia coli (E. coli). In addition, direct strategies and advance methods for bacteria imprinting completely reviewed. The deficiency and future perspective of BIPs sensors were discussed.
{"title":"A review of new emerging biosensors based on bacteria-imprinted polymers towards pathogenic bacteria: Promising new tools for selective detection","authors":"Chou-Yi Hsu , Jasur Alimdjanovich Rizaev , Harikumar Pallathadka , Sofiene Mansouri , Dmitry Olegovich Bokov , Snehlata Sharma , Gulshan Rathore , Pranchal Rajput , Yasser Fakri Mustafa , Munther Kadhim Abosaoda","doi":"10.1016/j.microc.2024.111918","DOIUrl":"10.1016/j.microc.2024.111918","url":null,"abstract":"<div><div>The spread of pathogenic bacteria in the environment, as a significant global issue, causes a substantial threat to human health, damaging economic development. Indeed, the development of sensitive and selective sensing approaches for detection of pathogenic bacteria is essential to prevent and treating infections. In this regard, biosensors as efficient analytical methods can play an important role. Importantly, exploiting of novel strategy can improve the performance of these biosensing platforms. Among different types, molecularly imprinted polymers (MIPs), as artificial receptors, that are developed to selective and sensitive biosensors. The distinct complementary cavities in these synthetic polymers contribute to their unique characteristics, as they are specifically tailored to their respective templates. Notably, bacteria-imprinted polymers (BIPs), as an important and novel member of MIPs, attracted considerable attention for different bacteria detection due to many cavities complementary to their bacteria. These novel probes can efficiently isolate various bacteria from wide range of samples such as food, water, or biological fluids due to the high affinity and selectivity. In this study, the application of BIPs in the structure of biosensors, as active area of research in the field of different bacteria detection, was reviewed for detection of <em>Staphylococcus aureus</em> (<em>S. aureus</em>), <em>Salmonella</em>, <em>Vibrio parahaemolyticus</em> (<em>(V. parahaemolyticus</em>) and <em>Escherichia coli</em> (<em>E. coli</em>). In addition, direct strategies and advance methods for bacteria imprinting completely reviewed. The deficiency and future perspective of BIPs sensors were discussed.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111918"},"PeriodicalIF":4.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As anthropogenic activities, industrialization, and technology have grown exponentially in recent decades, the presence of emerging contaminants (ECs) is increasing stress on fresh and sustainable water supplies due to their environmental toxicity. Therefore, a holistic approach is urgently required for the development of efficient technologies to bring the idea of wastewater remediation to fruition. Adsorption with biomass-based adsorbents can contribute to this perception as it offers numerous advantages over existing wastewater treatment technologies. This review ensures a thorough analysis of the potential application of natural sustainable adsorbents based on biomass for efficient removal of ECs including pharmaceuticals and personal care products (PPCPs), agrochemicals, aromatics, and microplastics (MPs). Various factors impacting the adsorption efficiency such as adsorbent dosage, concentration, contact time, pH, and temperature, along with the best-fitted models have been provided for the critical literature analysis. The adsorption mechanism involved was reviewed based on the point of zero charges of adsorbents, the ionic form of adsorbate, the hydrophobicity of adsorbate and adsorbent, surface functional groups, etc. Further, literature gaps were also identified and discussed for directing future research needed in the development of inexpensive, eco-friendly, efficient, reusable adsorbents with the overall process based on circular bio-economy and 4R (Reduce, Recycle, Re-use and Recover) approach, so that it can be commercialized to promote more sustainable futures.
{"title":"Biomass-based adsorbents for wastewater remediation: A systematic review on removal of emerging contaminants","authors":"Nishita Sharma , Aruna Yadav , Sarita Yadav , Partiksha Panghal , Sonika Singh , Aakash Deep , Surender Kumar","doi":"10.1016/j.microc.2024.111880","DOIUrl":"10.1016/j.microc.2024.111880","url":null,"abstract":"<div><div>As anthropogenic activities, industrialization, and technology have grown exponentially in recent decades, the presence of emerging contaminants (ECs) is increasing stress on fresh and sustainable water supplies due to their environmental toxicity. Therefore, a holistic approach is urgently required for the development of efficient technologies to bring the idea of wastewater remediation to fruition. Adsorption with biomass-based adsorbents can contribute to this perception as it offers numerous advantages over existing wastewater treatment technologies. This review ensures a thorough analysis of the potential application of natural sustainable adsorbents based on biomass for efficient removal of ECs including pharmaceuticals and personal care products (PPCPs), agrochemicals, aromatics, and microplastics (MPs). Various factors impacting the adsorption efficiency such as adsorbent dosage, concentration, contact time, pH, and temperature, along with the best-fitted models have been provided for the critical literature analysis. The adsorption mechanism involved was reviewed based on the point of zero charges of adsorbents, the ionic form of adsorbate, the hydrophobicity of adsorbate and adsorbent, surface functional groups, etc. Further, literature gaps were also identified and discussed for directing future research needed in the development of inexpensive, eco-friendly, efficient, reusable adsorbents with the overall process based on circular bio-economy and 4R (Reduce, Recycle, Re-use and Recover) approach, so that it can be commercialized to promote more sustainable futures.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111880"},"PeriodicalIF":4.9,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-11DOI: 10.1016/j.microc.2024.111884
Asiyeh Moteallemi , Mohammad Hadi Dehghani , Fatemeh Momeniha , Salah Azizi
Nanoplastics (NPs) with a size of less than 1 µm have received worldwide attention as an emerging environmental pollutant. Because they are easier for organisms to absorb, they pose higher ecological and health risks than microplastics. Natural water is a significant source of nanoplastics in the environment, and it is important for both human and ecosystem health. The analysis of nanoplastics in waters is still lacking reliable and harmonized methods. Most of the studies successfully identified and removed standard reference nanoplastics from environmental samples, but they were unable to quantify nanoplastics from real field samples. Here, we reviewed studies that measured and removed nanoplastics in environmental waters, such as seawater, rivers, drinking water, wastewater, snow, and so on. Pyrolysis gas chromatography–mass spectrometry (py-GC–MS) and surface-enhanced Raman spectroscopy were two common methods for analyzing nanoplastics in real samples. Mass spectrometry methods are time-consuming and cannot analyze the full nanorange due to particle size restrictions. This approach for measuring nanoplastic mass concentration may involve mistakes and require larger sample quantities. Various strategies for removing nanoplastics, including centrifugation, coagulation, filtration, flocculation, and adsorption, were reviewed. The effectiveness of nanoplastic removal is influenced by parameters such as source, size, type, and purification process. The removal efficiency for nanoplastics is 99 % when combined with filtration and coagulation processes. This study provides basic information for future research on the analysis and removal of nanoplastics from water and wastewater.
{"title":"Nanoplastics as emerging contaminants: A systematic review of analytical processes, removal strategies from water environments, challenges and perspective","authors":"Asiyeh Moteallemi , Mohammad Hadi Dehghani , Fatemeh Momeniha , Salah Azizi","doi":"10.1016/j.microc.2024.111884","DOIUrl":"10.1016/j.microc.2024.111884","url":null,"abstract":"<div><div>Nanoplastics (NPs) with a size of less than 1 µm have received worldwide attention as an emerging environmental pollutant. Because they are easier for organisms to absorb, they pose higher ecological and health risks than microplastics. Natural water is a significant source of nanoplastics in the environment, and it is important for both human and ecosystem health. The analysis of nanoplastics in waters is still lacking reliable and harmonized methods. Most of the studies successfully identified and removed standard reference nanoplastics from environmental samples, but they were unable to quantify nanoplastics from real field samples. Here, we reviewed studies that measured and removed nanoplastics in environmental waters, such as seawater, rivers, drinking water, wastewater, snow, and so on. Pyrolysis gas chromatography–mass spectrometry (py-GC–MS) and surface-enhanced Raman spectroscopy were two common methods for analyzing nanoplastics in real samples. Mass spectrometry methods are time-consuming and cannot analyze the full nanorange due to particle size restrictions. This approach for measuring nanoplastic mass concentration may involve mistakes and require larger sample quantities. Various strategies for removing nanoplastics, including centrifugation, coagulation, filtration, flocculation, and adsorption, were reviewed. The effectiveness of nanoplastic removal is influenced by parameters such as source, size, type, and purification process. The removal efficiency for nanoplastics is 99 % when combined with filtration and coagulation processes. This study provides basic information for future research on the analysis and removal of nanoplastics from water and wastewater.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111884"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-11DOI: 10.1016/j.microc.2024.111903
Marcello Locatelli , Abuzar Kabir , Miryam Perrucci , Halil Ibrahim Ulusoy , Songül Ulusoy , Natalia Manousi , Victoria Samanidou , Imran Ali , Sariye Irem Kaya , Fotouh R. Mansour , Ahmet Cetinkaya , Sibel A. Ozkan
In the last century, in the analytical field, the interest of researchers in the preliminary phases of the analysis has grown more and more, giving space to important innovations in the field of sample preparation, but above all leading to a renewed interest in this field. It is known that these phases are the most critical of the entire analytical process not only in terms of time, but also in terms of final measurement error. In this perspective, in recent years a growing interest of the Scientific Community and important efforts have been directed towards not only the development of innovative techniques that allow a reduction in sample manipulation while maintaining high analytical performance, but at the same time also towards a reduction in the environmental impact that such procedures can have. In this direction, there is also the possibility of intervening to reduce the quantity of sample processed and, consequently, obtain a reduction in the volumes of solvents and non-green reagents.
The main objective of this review is to provide an overview of the literature focused on the most modern sorbent-based sampling and sample preparation techniques that are applied (or have been recently developed) in the three main “sections” of instrumental analysis (sensor-based analysis, electrochemical analysis and chromatography-based analysis). In particular, the Authors wanted to outline the main advantages and disadvantages of the different procedures and above all evaluate how the different methods are applied in the field of biological matrix analysis (biological fluids, tissues, etc.). A final paragraph also considers an evaluation and estimate (using the most recent tools) for the environmental impact assessment and how they can be applied in this field (AGREE, AGREEprep, and MoGAPI). Through these applications it is also evaluated how continuous improvement is possible by checking the “critical” points and remedying/optimizing the procedures in this sense.
The present review finally concludes with a section on future perspectives in which the Authors (based on their vast experience in their respective fields of application) have tried to hypothesize a possible future and a possible way to be considered to ensure that this part of the analytical process can further progress and support the new challenges that daily arise in the field of bioanalytical applications.
{"title":"Recent trends in sampling and sorbent-based sample preparation procedures for bioanalytical applications","authors":"Marcello Locatelli , Abuzar Kabir , Miryam Perrucci , Halil Ibrahim Ulusoy , Songül Ulusoy , Natalia Manousi , Victoria Samanidou , Imran Ali , Sariye Irem Kaya , Fotouh R. Mansour , Ahmet Cetinkaya , Sibel A. Ozkan","doi":"10.1016/j.microc.2024.111903","DOIUrl":"10.1016/j.microc.2024.111903","url":null,"abstract":"<div><div>In the last century, in the analytical field, the interest of researchers in the preliminary phases of the analysis has grown more and more, giving space to important innovations in the field of sample preparation, but above all leading to a renewed interest in this field. It is known that these phases are the most critical of the entire analytical process not only in terms of time, but also in terms of final measurement error. In this perspective, in recent years a growing interest of the Scientific Community and important efforts have been directed towards not only the development of innovative techniques that allow a reduction in sample manipulation while maintaining high analytical performance, but at the same time also towards a reduction in the environmental impact that such procedures can have. In this direction, there is also the possibility of intervening to reduce the quantity of sample processed and, consequently, obtain a reduction in the volumes of solvents and non-green reagents.</div><div>The main objective of this review is to provide an overview of the literature focused on the most modern sorbent-based sampling and sample preparation techniques that are applied (or have been recently developed) in the three main “sections” of instrumental analysis (sensor-based analysis, electrochemical analysis and chromatography-based analysis). In particular, the Authors wanted to outline the main advantages and disadvantages of the different procedures and above all evaluate how the different methods are applied in the field of biological matrix analysis (biological fluids, tissues, etc.). A final paragraph also considers an evaluation and estimate (using the most recent tools) for the environmental impact assessment and how they can be applied in this field (AGREE, AGREEprep, and MoGAPI). Through these applications it is also evaluated how continuous improvement is possible by checking the “critical” points and remedying/optimizing the procedures in this sense.</div><div>The present review finally concludes with a section on future perspectives in which the Authors (based on their vast experience in their respective fields of application) have tried to hypothesize a possible future and a possible way to be considered to ensure that this part of the analytical process can further progress and support the new challenges that daily arise in the field of bioanalytical applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111903"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-11DOI: 10.1016/j.microc.2024.111907
Laetitia Maidodou , Damien Steyer , Marie-Anaïs Monat , Michelle Leemans , Isabelle Fromantin , Eric Marchioni , Igor Clarot
Pathologies such as cancers or infectious diseases can induce modifications in the concentrations of urinary volatile metabolites. Indeed, urine is a large source of Volatile Organic Compounds (VOCs) from the human body. Canine olfaction and Gas Chromatography coupled to Mass Spectrometry (GC–MS) systems are promising tools for the development of non-invasive diagnosis methods based on the analysis of urine. This review paper aims to provide an overview of materials and methods found in the literature for urinary VOCs analysis by detection dogs and GC–MS instruments. It highlights the impact of urine collection procedures and storage conditions. Then, sample preparation protocols for canine olfaction are discussed, as well as for GC–MS analysis, focusing on headspace-based extraction techniques. In the case of instrumental analysis, a significant variability of volatile profiles can be observed depending on the sample preparation (urine pH, extraction methods), and analytical parameters. Lastly, limitations of urinary VOCs analysis for medical diagnosis purposes are considered.
{"title":"Harnessing the potential of sniffing dogs and GC–MS in analyzing human urine: A comprehensive review of sample preparation and extraction techniques","authors":"Laetitia Maidodou , Damien Steyer , Marie-Anaïs Monat , Michelle Leemans , Isabelle Fromantin , Eric Marchioni , Igor Clarot","doi":"10.1016/j.microc.2024.111907","DOIUrl":"10.1016/j.microc.2024.111907","url":null,"abstract":"<div><div>Pathologies such as cancers or infectious diseases can induce modifications in the concentrations of urinary volatile metabolites. Indeed, urine is a large source of Volatile Organic Compounds (VOCs) from the human body. Canine olfaction and Gas Chromatography coupled to Mass Spectrometry (GC–MS) systems are promising tools for the development of non-invasive diagnosis methods based on the analysis of urine. This review paper aims to provide an overview of materials and methods found in the literature for urinary VOCs analysis by detection dogs and GC–MS instruments. It highlights the impact of urine collection procedures and storage conditions. Then, sample preparation protocols for canine olfaction are discussed, as well as for GC–MS analysis, focusing on headspace-based extraction techniques. In the case of instrumental analysis, a significant variability of volatile profiles can be observed depending on the sample preparation (urine pH, extraction methods), and analytical parameters. Lastly, limitations of urinary VOCs analysis for medical diagnosis purposes are considered.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111907"},"PeriodicalIF":4.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.microc.2024.111878
Miao Liu , Kayhaneh Berijani , Jiaxin Ma , Sirui Guo , Yanqiong Peng , Ying Pan , Ali Morsali , Yong Huang
According to the continuous development of today’s society, the production of environmental pollutants has been a severe concern observed in the drug industries. For instance, the demand for the consumption of antibiotics is one of them that is increasing, and the residual hazards of the broad-spectrum antibiotic chloramphenicol (CAP) are widespread, which can not only pollute the environment but can also have negative health impacts on humans. Thus, the detection of CAP is of great significance. Among the used chemical materials to solve this issue, the essential metal–organic skeletons, namely metal–organic frameworks (MOFs) have promising applications due to their advantages such as large specific surface area (SA), abundant pores, and luminescent properties. This paper describes the principles of electrochemical, fluorescent, and probe assays related to the detection of CAP. A more comprehensive overview of the use of MOFs for the detection of CAP and other antibiotics in water and food and how CAP can be monitored with high sensitivity, high selectivity, and stability in the form of various sensors is given, as well as future perspectives on MOFs materials that have the potential to be used as sensors.
随着当今社会的不断发展，环境污染物的产生已成为药品行业严重关注的问题。例如，人们对抗生素的消费需求与日俱增，而广谱抗生素氯霉素（CAP）的残留危害十分普遍，不仅会污染环境，还会对人体健康产生负面影响。因此，CAP 的检测意义重大。在用于解决这一问题的化学材料中，重要的金属有机骨架，即金属有机框架（MOFs）因其具有大比表面积（SA）、丰富的孔隙和发光特性等优点而具有广阔的应用前景。本文介绍了与检测 CAP 相关的电化学、荧光和探针测定原理。本文更全面地概述了如何利用 MOFs 检测水和食品中的 CAP 及其他抗生素，以及如何以各种传感器的形式高灵敏度、高选择性和高稳定性地监测 CAP，并展望了有可能用作传感器的 MOFs 材料的未来前景。
{"title":"Recent advances and principles of metal–organic framework for the detection of chloramphenicol: Perspectives and challenges","authors":"Miao Liu , Kayhaneh Berijani , Jiaxin Ma , Sirui Guo , Yanqiong Peng , Ying Pan , Ali Morsali , Yong Huang","doi":"10.1016/j.microc.2024.111878","DOIUrl":"10.1016/j.microc.2024.111878","url":null,"abstract":"<div><div>According to the continuous development of today’s society, the production of environmental pollutants has been a severe concern observed in the drug industries. For instance, the demand for the consumption of antibiotics is one of them that is increasing, and the residual hazards of the broad-spectrum antibiotic chloramphenicol (CAP) are widespread, which can not only pollute the environment but can also have negative health impacts on humans. Thus, the detection of CAP is of great significance. Among the used chemical materials to solve this issue, the essential metal–organic skeletons, namely metal–organic frameworks (MOFs) have promising applications due to their advantages such as large specific surface area (SA), abundant pores, and luminescent properties. This paper describes the principles of electrochemical, fluorescent, and probe assays related to the detection of CAP. A more comprehensive overview of the use of MOFs for the detection of CAP and other antibiotics in water and food and how CAP can be monitored with high sensitivity, high selectivity, and stability in the form of various sensors is given, as well as future perspectives on MOFs materials that have the potential to be used as sensors.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111878"},"PeriodicalIF":4.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142445820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-10DOI: 10.1016/j.microc.2024.111858
M.A. Diab , Heba A. El-Sabban , Kwang-Hyun Baek
Fumonisins (FMS), a class of Mycotoxins mostly produced by fusarium species, are found in polluted food and feed and can seriously harm humans and animals. To ensure food safety and regulatory compliance, accurate and dependable analytical techniques are utilized in detecting and measuring these pollutants. This mini-review focused on sophisticated clean-up techniques for Fumonisin (FM) analysis utilizing molecularly imprinted polymer solid phase extraction (MIPSPE). The majority of the molecularly imprinted polymers (MIPs) categories that are intended to extract FMs from the food matrix were discussed, along with a list of well-known chromatographic techniques and MIP-based electrochemical sensors to detect FMs.
By imitating FM-specific natural sites, MIPSPE provides great selectivity, sensitivity, and reproducibility while improving the accuracy of subsequent analytical tests. This review includes the synthesis of MIPs, extraction protocol optimization, and integration with several detection techniques like High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectroscopy (LC-MS). It also covers recent advancements in MIPSPE technology.
{"title":"Toward advanced analytical procedures for detecting Fumonisins in contaminated food and feed using molecularly imprinted polymers: A mini review","authors":"M.A. Diab , Heba A. El-Sabban , Kwang-Hyun Baek","doi":"10.1016/j.microc.2024.111858","DOIUrl":"10.1016/j.microc.2024.111858","url":null,"abstract":"<div><div>Fumonisins (FMS), a class of Mycotoxins mostly produced by fusarium species, are found in polluted food and feed and can seriously harm humans and animals. To ensure food safety and regulatory compliance, accurate and dependable analytical techniques are utilized in detecting and measuring these pollutants. This mini-review focused on sophisticated clean-up techniques for Fumonisin (FM) analysis utilizing molecularly imprinted polymer solid phase extraction (MIPSPE). The majority of the molecularly imprinted polymers (MIPs) categories that are intended to extract FMs from the food matrix were discussed, along with a list of well-known chromatographic techniques and MIP-based electrochemical sensors to detect FMs<strong>.</strong></div><div>By imitating FM-specific natural sites, MIPSPE provides great selectivity, sensitivity, and reproducibility while improving the accuracy of subsequent analytical tests. This review includes the synthesis of MIPs, extraction protocol optimization, and integration with several detection techniques like High-Performance Liquid Chromatography <strong>(</strong>HPLC) and Liquid Chromatography-Mass Spectroscopy (LC-MS). It also covers recent advancements in MIPSPE technology.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111858"},"PeriodicalIF":4.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cardiovascular disease (CVD) is the leading cause of global mortality. Early identification of CVD and subsequent intervention can significantly improve treatment outcomes. A successful approach to promptly diagnose CVD involves identifying biomarkers present in bodily fluids. Apolipoprotein B-100 (apoB-100) is a critical biomarker associated with CVD and plays a significant role in its progression. Elevated levels of apoB-100 (>100 mg/dL) are linked to a higher risk of CVD, underscoring its importance for accurate diagnosis and effective treatment strategies. Electrochemical biosensors offer advantages in monitoring apoB-100 due to their speed, portability, and on-site analysis capabilities. This review provides a comprehensive analysis of how apoB-100 levels change in biological fluids as CVD advances. It includes a detailed explanation of the construction and analytical capabilities of various electrochemical sensors. A comparison of electrochemical biosensors using amperometric, potentiometric, voltammetric, conductometric, and impedimetric methods is presented. Additionally, the suitability of these sensors for measuring apoB-100 in clinical samples, including serum, plasma, whole blood, and other bodily fluids, is evaluated. Furthermore, the challenges associated with electrochemical sensors as diagnostic tools for apoB-100 in CVD biomarker detection are examined, and potential future directions and trends are outlined.
{"title":"The role of electrochemical biosensors in monitoring Apolipoprotein B-100 as a diagnostic tool for cardiovascular disease","authors":"Sara Ranjbari , Wael Almahmeed , Prashant Kesharwani , Amirhossein Sahebkar","doi":"10.1016/j.microc.2024.111867","DOIUrl":"10.1016/j.microc.2024.111867","url":null,"abstract":"<div><div>Cardiovascular disease (CVD) is the leading cause of global mortality. Early identification of CVD and subsequent intervention can significantly improve treatment outcomes. A successful approach to promptly diagnose CVD involves identifying biomarkers present in bodily fluids. Apolipoprotein B-100 (apoB-100) is a critical biomarker associated with CVD and plays a significant role in its progression. Elevated levels of apoB-100 (>100 mg/dL) are linked to a higher risk of CVD, underscoring its importance for accurate diagnosis and effective treatment strategies. Electrochemical biosensors offer advantages in monitoring apoB-100 due to their speed, portability, and on-site analysis capabilities. This review provides a comprehensive analysis of how apoB-100 levels change in biological fluids as CVD advances. It includes a detailed explanation of the construction and analytical capabilities of various electrochemical sensors. A comparison of electrochemical biosensors using amperometric, potentiometric, voltammetric, conductometric, and impedimetric methods is presented. Additionally, the suitability of these sensors for measuring apoB-100 in clinical samples, including serum, plasma, whole blood, and other bodily fluids, is evaluated. Furthermore, the challenges associated with electrochemical sensors as diagnostic tools for apoB-100 in CVD biomarker detection are examined, and potential future directions and trends are outlined.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111867"},"PeriodicalIF":4.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-05DOI: 10.1016/j.microc.2024.111846
Sohan G. Jawarkar, Megha Pillai, Prasad Chavan, Pinaki Sengupta
Smart biomaterials are gaining increasing importance in the field of bioanalytical sciences because of the unique ability to change their inherent properties as per need. Recently, many advancements have been witnessed in the storage techniques of biological samples in solid state. Among these, dried blood spot and dried plasma spot methods have unique advantages as cutting-edge approaches. However, such methods are capable to accommodate only a very low volume of sample. To overcome this limitation, the application of smart biomaterial for the storage and extraction of biological samples is now being widely explored. The primary focus of this review is to assess the potential of smart biomaterial for the storage and extraction of bioanalytical samples. The applicability of biomaterials as sorbents for bioanalytical sample extraction and storage emphasizing their unique nature, characterization techniques, and constraints are critically evaluated in this review. Furthermore, applications of biomaterials in tissue engineering, drug delivery, and 3D-printing showcasing their potential to address key challenges in healthcare have been discussed. This review provides a clear-insights into the future directions of smart biomaterial as a sorbent for bioanalytical sample preparation and storage. Interdisciplinary collaboration and translational efforts are identified as a need of the hour to harness the full potential of smart biomaterials in clinical applications.
{"title":"Next-generation smart biomaterials for storage and extraction of bioanalytical samples: Current standing and path forward","authors":"Sohan G. Jawarkar, Megha Pillai, Prasad Chavan, Pinaki Sengupta","doi":"10.1016/j.microc.2024.111846","DOIUrl":"10.1016/j.microc.2024.111846","url":null,"abstract":"<div><div>Smart biomaterials are gaining increasing importance in the field of bioanalytical sciences because of the unique ability to change their inherent properties as per need. Recently, many advancements have been witnessed in the storage techniques of biological samples in solid state. Among these, dried blood spot and dried plasma spot methods have unique advantages as cutting-edge approaches. However, such methods are capable to accommodate only a very low volume of sample. To overcome this limitation, the application of smart biomaterial for the storage and extraction of biological samples is now being widely explored. The primary focus of this review is to assess the potential of smart biomaterial for the storage and extraction of bioanalytical samples. The applicability of biomaterials as sorbents for bioanalytical sample extraction and storage emphasizing their unique nature, characterization techniques, and constraints are critically evaluated in this review. Furthermore, applications of biomaterials in tissue engineering, drug delivery, and 3D-printing showcasing their potential to address key challenges in healthcare have been discussed. This review provides a clear-insights into the future directions of smart biomaterial as a sorbent for bioanalytical sample preparation and storage. Interdisciplinary collaboration and translational efforts are identified as a need of the hour to harness the full potential of smart biomaterials in clinical applications.</div></div>","PeriodicalId":391,"journal":{"name":"Microchemical Journal","volume":"207 ","pages":"Article 111846"},"PeriodicalIF":4.9,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142418742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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