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Corrigendum to “Biodegradable multimodal biomaterials with microenvironmental adaptability and orderly delivery of H2S and bFGF for the treatment of spinal cord injury” [Nano Today 66 (2026) 102890] “具有微环境适应性和有序输送H2S和bFGF的可生物降解多模态生物材料用于脊髓损伤治疗”的勘误表[Nano Today 66 (2026) 102890]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-10-09 DOI: 10.1016/j.nantod.2025.102914

Junqing Huang , Jiamen Shen , Yu Huang , Yanfang Zhao , Yibo Ying , Yanran Bi , Liuxi Chu , Xinwang Ying , Qian Xu , Junpeng Xu , Ping Wu , Jiansong Ji , Zhouguang Wang

引用次数: 0

Dynamic hydration layer and ion-release synergy in coatings: Unraveling the key to sustainable anti-scaling during boiling and energy conservation 涂料中的动态水合层和离子释放协同作用：揭示沸煮过程中可持续防结垢和节能的关键

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-12-22 DOI: 10.1016/j.nantod.2025.102964

Ran Zhao , Jianmin Gu , Zhihao Shang , Xiaopeng Cheng , Chunxiao Liang , Desong Wang , Shutao Wang , Jingxin Meng

Scale deposition severely degrades the heat-transfer efficiency of industrial equipment, leading to substantial energy wastage. While several advanced scalephobic surfaces have been developed to mitigate scaling, their poor stability under harsh operating conditions hinders practical implementation. Herein, we report a dynamic hydration layer-synergistic ion-releasing (DHLIR) coating that exhibits exceptional energy-saving potential, enabled by ultrahigh scale resistance under boiling conditions. The DHLIR coating was facilely fabricated via a combined spraying and heat-treatment process, utilizing aluminum phosphate (AP) as the inorganic binder, titanium dioxide (TiO₂) nanoparticles as the structural reinforcement phase, and hexagonal boron nitride (hBN) nanosheets as the thermally conductive filler. Notably, the superior scalephobic performance of the DHLIR coating stems from two key mechanisms: the surface hydration layer minimizes mineral ion adsorption, while the released scale inhibitors reduce scale adhesion. Furthermore, the DHLIR coating demonstrates robust durability under extreme environments, including high temperatures, abrasion, and corrosive liquids. In a simulated industrial boiler setup, the DHLIR coating conserved approximately 15.3 % of energy compared to stainless steel. This work thus presents a promising strategy for anti-scaling and energy conservation in boiling environments.

结垢严重降低了工业设备的传热效率，造成了大量的能源浪费。虽然已经开发了几种先进的防垢表面来减轻结垢，但它们在恶劣操作条件下的稳定性差阻碍了实际实施。在此，我们报道了一种动态水化层协同离子释放（DHLIR）涂层，该涂层在沸腾条件下具有超高的抗垢性，具有卓越的节能潜力。以磷酸铝（AP）为无机粘结剂，二氧化钛（tio2）纳米颗粒为结构增强相，六方氮化硼（hBN）纳米片为导热填料，采用喷涂与热处理相结合的方法制备了DHLIR涂层。值得注意的是，DHLIR涂层优越的阻垢性能源于两个关键机制：表面水化层最大限度地减少了矿物离子的吸附，而释放的阻垢剂减少了垢的粘附。此外，DHLIR涂层在极端环境下（包括高温、磨损和腐蚀性液体）表现出强大的耐久性。在模拟工业锅炉设置中，与不锈钢相比，DHLIR涂层节省了大约15.3% %的能量。因此，这项工作提出了一种在沸腾环境中抗结垢和节能的有前途的策略。

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引用次数: 0

Cyclic D/L-peptides based nanoparticles regulates dendritic cell maturation and enhances anti-tumor immune response 基于环D/ l肽的纳米颗粒调节树突状细胞成熟并增强抗肿瘤免疫反应

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-11-18 DOI: 10.1016/j.nantod.2025.102931

Wei Hu , Jiaxi Xu , Mingchen Lv , Min Sun , Zhen Fan , Jianzhong Du

Immunotherapy offers enduring cancer treatment by activating the immune system to eliminate cancer cells, but faces challenges like tumor immune evasion and low immunogenicity. Chirality, crucial in biological interactions, remains underexplored for immune modulation. Inspired by the metal-binding domain of manganese superoxide dismutase, we develop a cyclic D/L peptide for chirality-driven immune activation. The cyclic L-Tyr-D-His-L-Asp-D-His (YhDh) peptide coordinates with Mn²⁺ to self-assemble into nanoparticles, cloak with tumor cell membranes for homologous targeting. Compared to all-L or all-D peptides, YhDh nanoparticles promote costimulatory molecule expression on dendritic cells (DCs). Upon intravenous administration, they are oxidized at melanoma sites with tyrosinase overexpression, enabling photothermal-induced immunogenic cell death (ICD). Chiral peptides synergize with Mn²⁺-mediated cGAS-STING activation and ICD, enhancing DC maturation and T cell infiltration (4.36- and 2.88-fold), suppressing tumor metastasis while establishing immune memory. Such chiral cyclic peptides offer a novel strategy for immune activation by regulating peptide chirality.

免疫疗法通过激活免疫系统来消除癌细胞，提供了持久的癌症治疗，但面临着肿瘤免疫逃避和低免疫原性等挑战。手性在生物相互作用中至关重要，但在免疫调节方面仍未得到充分的研究。受锰超氧化物歧化酶金属结合结构域的启发，我们开发了一种手性驱动免疫激活的环D/L肽。环状的L-Tyr-D-His-L-Asp-D-His （YhDh）肽与Mn2+配合，自组装成纳米颗粒，包裹在肿瘤细胞膜上进行同源靶向。与全l或全d肽相比，YhDh纳米颗粒促进树突状细胞（dc）上的共刺激分子表达。经静脉注射后，它们在酪氨酸酶过度表达的黑色素瘤部位被氧化，使光热诱导的免疫原性细胞死亡（ICD）成为可能。手性肽与Mn2+介导的cGAS-STING激活和ICD协同作用，促进DC成熟和T细胞浸润（分别为4.36和2.88倍），抑制肿瘤转移，同时建立免疫记忆。这种手性环肽通过调节肽的手性为免疫激活提供了一种新的策略。

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引用次数: 0

Electronic cloud-regulation strategy enabling rapid and sensitive near-infrared detection of ONOO⁻ for dynamic monitoring of ferroptosis-mediated drug-induced liver injury 电子云调节策略，实现ONOO的快速和灵敏的近红外检测，用于动态监测铁中毒介导的药物性肝损伤

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-09-12 DOI: 10.1016/j.nantod.2025.102900

Yongchuang Li , Haiyue Liu , Yuru Liu , Shaowei Wang , Caixia Yin , Fangjun Huo

Drug-induced liver injury (DILI) is caused by hepatotoxic effects resulting from drug metabolism. Extensive studies have demonstrated a close association between DILI progression and ferroptosis, a process characterized by redox imbalance triggered by lipid peroxidation. As a key product of redox imbalance and a critical biomarker of DILI, peroxynitrite (ONOO^-) plays a pivotal regulatory role in ferroptosis. To elucidate the precise mechanism of ONOO^- in ferroptosis-mediated DILI, there is an urgent need for ONOO^- fluorescent probes with high specificity, sensitivity and signal-to-noise ratio. This study innovatively modified the traditional pyridine hemicyanine fluorophore into a quinoline hemicyanine structure, achieving a red-shifted fluorescence emission wavelength through extended conjugation and enhanced electron delocalization. Systematic site screening identified diphenyl phosphate ester as the optimal reaction site, demonstrating exceptional specificity, sensitivity and 75 s response characteristics. By conjugating the optimized fluorophore with the reaction site via nucleophilic substitution, we successfully developed a novel ratiometric fluorescent probe, zt-4. Given the remarkable similarities in pathological mechanisms (including signaling pathways, regulatory nodes, and biomarkers) between osteoarthritis (OA) and DILI, we first validated the imaging performance of zt-4 in a complex inflammatory OA Model. Subsequently, we applied probe zt-4 to analyze ferroptosis-mediated DILI model at both cellular and murine levels. For the first time, our study revealed that the ferroptosis pathway dynamically regulates ONOO^- levels in DILI, elucidating its molecular mechanism. These findings provide new theoretical foundations and intervention strategies for DILI treatment.

药物性肝损伤（DILI）是由药物代谢引起的肝毒性作用引起的。大量研究表明DILI进展与铁下垂密切相关，这一过程以脂质过氧化引发的氧化还原失衡为特征。作为氧化还原失衡的关键产物和DILI的重要生物标志物，过氧亚硝酸盐（ONOO-）在铁凋亡中起着关键的调节作用。为了阐明ONOO-在死铁介导的DILI中的确切机制，迫切需要具有高特异性、高灵敏度和高信噪比的ONOO-荧光探针。本研究创新性地将传统的吡啶半苯胺荧光团修饰为喹啉半苯胺结构，通过扩展共轭和增强电子离域实现了荧光发射波长的红移。系统的位点筛选确定磷酸二苯酯为最佳反应位点，表现出优异的特异性、敏感性和75 s的响应特性。通过亲核取代将优化的荧光团与反应位点偶联，我们成功地开发了一种新型的比例荧光探针zt-4。鉴于骨关节炎（OA）和DILI在病理机制（包括信号通路、调节节点和生物标志物）上的显著相似性，我们首先验证了zt-4在复杂炎性OA模型中的成像性能。随后，我们应用探针zt-4在细胞和小鼠水平上分析了铁中毒介导的DILI模型。本研究首次揭示了铁下垂途径动态调控DILI中ONOO-水平，阐明了其分子机制。这些发现为DILI的治疗提供了新的理论基础和干预策略。

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引用次数: 0

ROS/NO dual-releasing organic polymer nanoenzymes for NIR-II photo-adjuvant cancer immunotherapy ROS/NO双释放有机聚合物纳米酶用于NIR-II光辅助癌症免疫治疗

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.nantod.2025.102936

Jiayao Ding , Long Wang , Fengshuo Wang , Yue Liu , Haidong Chen , Jingchao Li , Ting Su

Nitric oxide (NO) and reactive oxygen species (ROS) are crucial signal molecules in living systems, providing alternative strategies for cancer treatment other than chemotherapy drug. Nevertheless, the uncontrollable ROS/NO induction will lead to low therapeutic results and potential off-target effects. In this paper, ROS/NO dual-releasing organic polymeric nanoenzymes (O₂^·-/NO-SPN) are designed, capable of synergistically elevating ROS and NO levels in tumors upon second near-infrared (NIR-II) photo-triggered activation, thus establishing a photoactivated adjuvant strategy for enhanced cancer immunotherapy. A newly synthesized semiconducting polymer (L7) with an outstanding NIR-II photothermal performance is utilized as the core for fabricating such nanoenzymes. Using a film-dispersion technique coupled with hydration, a NO donor S-nitrosoglutathione (GSNO), superoxide anions (O₂^·-) donor 3-indoleacetic acid (3IAA) and L7 are co-loaded in a thermal-responsive nano-liposome, followed by surface embellishment of horseradish peroxidase (HRP). The formed O₂^·-/NO-SPN can generate local heat via NIR-II photothermal effect, and thus the thermal-responsive nano-liposomes are collapsed to release 3IAA, which is then catalyzed by HRP to produce O₂^·-, triggering tumor cell death in a NIR-II photodynamic-like manner. Moreover, the local heating effect results in production of NO by GSNO to further kill tumor cells and also activate the systemic immune responses through inducing immunogenic cell death and macrophage polarization. This ROS/NO dual-releasing strategy is demonstrated to effectively inhibit bilateral tumor growths and metastasis. The current study thereby offers a promising tool to regulate both ROS and NO levels concurrently in biological systems.

一氧化氮（NO）和活性氧（ROS）是生命系统中至关重要的信号分子，为癌症治疗提供了化疗药物以外的替代策略。然而，不可控的ROS/NO诱导将导致低治疗效果和潜在的脱靶效应。本文设计了ROS/NO双释放有机聚合物纳米酶（O2·-/NO- spn），在第二次近红外（NIR-II）光触发激活下，能够协同提高肿瘤中ROS和NO的水平，从而建立了一种增强癌症免疫治疗的光激活佐剂策略。一种新合成的半导体聚合物（L7）具有优异的NIR-II光热性能，被用作制造这种纳米酶的核心。利用膜分散技术和水合作用，将NO供体s -亚硝基谷胱甘肽（GSNO）、超氧阴离子（O2·-）供体3-吲哚乙酸（3IAA）和L7共负载在热响应的纳米脂质体中，然后在表面修饰辣根过氧化物酶（HRP）。形成的O2·-/NO-SPN通过NIR-II光热效应产生局部热量，热响应的纳米脂质体被分解释放3IAA， 3IAA被HRP催化生成O2·-，以类似NIR-II光动力学的方式触发肿瘤细胞死亡。此外，局部加热效应导致GSNO产生NO进一步杀伤肿瘤细胞，并通过诱导免疫原性细胞死亡和巨噬细胞极化激活全身免疫反应。这种ROS/NO双释放策略被证明能有效抑制双侧肿瘤的生长和转移。因此，目前的研究提供了一种有前途的工具来同时调节生物系统中的ROS和NO水平。

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引用次数: 0

Advanced strategies for extending the blood circulation time of nano-based delivery systems 延长纳米给药系统血液循环时间的先进策略

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-18 DOI: 10.1016/j.nantod.2026.102978

Mohammad Reza Kandi , Amir Zarebkohan , Donya Shaterabadi , Roya Salehi , Babak Negahdari , Michael R. Hamblin

The rapid clearance of nano‑based delivery systems has motivated the search for strategies to extend the blood circulation time. This review moves beyond traditional strategies used for the design of extended blood‑circulation nanomaterials, and examines some recent advances in two complementary domains: physicochemical optimization and biological modulation. This review highlights trends in chemical and topological modifications regarding PEGylation, and shows that the transition to alternative polymers is accompanied by a set of challenges and advantages. It also examines various types of transformable nanoparticles and highlights the dangers inherent in stimulus heterogeneity and the complexity of their manufacturing process. The innovations and challenges of protein‑corona engineering are likewise evaluated. Furthermore, the modulation of complement and macrophage pathways as major immunological barriers promoting rapid NP clearance is discussed, and new approaches such as complement inhibitors and mononuclear phagocyte system blockade are explored. In addition, hitchhiking and biomimetic systems are discussed as emerging strategies to enhance blood circulation. Finally, we discuss the transition from static systems to dynamic, biointeractive, targeted and controllable platforms for achieving prolonged blood circulation.

纳米基给药系统的快速清除促使人们寻找延长血液循环时间的策略。这篇综述超越了用于扩展血液循环纳米材料设计的传统策略，并研究了两个互补领域的一些最新进展：物理化学优化和生物调节。这篇综述强调了聚乙二醇化的化学和拓扑修饰的趋势，并表明向替代聚合物的过渡伴随着一系列的挑战和优势。它还检查了各种类型的可变形纳米颗粒，并强调了刺激异质性和制造过程复杂性所固有的危险。本文还对蛋白冠工程的创新和挑战进行了评价。此外，本文还讨论了补体和巨噬细胞通路作为促进NP快速清除的主要免疫屏障的调节，并探索了补体抑制剂和单核吞噬细胞系统阻断等新方法。此外，搭便车和仿生系统被讨论为促进血液循环的新兴策略。最后，我们讨论了从静态系统到动态、生物相互作用、靶向和可控平台的过渡，以实现延长血液循环。

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引用次数: 0

Inside Back Cover - Graphical abstract TOC/TOC in double column continued from OBC if required, otherwise blank page 封底内-图解摘要TOC/TOC双栏，如果需要，从OBC继续，否则空白页

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/S1748-0132(26)00019-8

引用次数: 0

Outside Back Cover - Graphical abstract TOC/TOC in double column/Cover image legend if applicable, Bar code, Abstracting and Indexing information 封底外-图形摘要TOC/双栏TOC/封面图例（如适用），条形码，摘要和索引信息

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1016/S1748-0132(26)00020-4

引用次数: 0

Biomimetic nanomaterial-based strategies for spinal cord injury repair 基于仿生纳米材料的脊髓损伤修复策略

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-10 DOI: 10.1016/j.nantod.2025.102969

Rui-Lian Chen , Lu Jiang , Hai-Bo Teng , Jin-Long Yang , Wen-Bo He , Yang Zhang , Qing-qing Ren , Hong-Xu Chen , Rang-rang Fan , Jian-Guo Xu

Spinal cord injury (SCI) poses significant clinical challenges marked by profound functional impairments and limited clinical interventions due to its complex pathological microenvironment and limited intrinsic regenerative capacity. This review systematically explores the pathophysiology of SCI, emphasizing key therapeutic targets in neuroprotection, axon regeneration, and immunomodulation. We innovatively propose a functional classification framework to categorize synthetic nanomaterials into (1) targeted drug delivery systems, (2) nanoparticle-hydrogel hybrid systems and (3) stimuli-responsive functional nanoparticles, effectively resolving overlaps in traditional classifications. Furthermore, biogenic nanomaterials—including exosomes, cell membrane-coated systems, and decellularized extracellular matrix (ECM) scaffolds—are highlighted for their innate biocompatibility, immune evasion, and bioactivity. These biogenic nanomaterials synergize with advanced technologies such as genetic engineering and combinatorial therapies to enhance neural repair. Particularly, we provide the first systematic comparison of microstructural differences in decellularized scaffolds derived from diverse tissues (e.g., spinal cord, optic nerve, sciatic nerve) and their mechanisms in guiding axonal regeneration. Despite promising preclinical outcomes, challenges such as standardization, scalable production and long-term biosafety remain in the gap between experimental models and clinical applications. Future directions focus on dynamic responsiveness, multifunctional combinatorial designs and integration with regenerative medicine paradigms to achieve functional recovery in SCI management.

脊髓损伤（SCI）由于其复杂的病理微环境和有限的内在再生能力，造成了严重的功能障碍和有限的临床干预，给临床带来了重大挑战。本文系统地探讨了脊髓损伤的病理生理学，强调了神经保护、轴突再生和免疫调节方面的关键治疗靶点。我们创新地提出了一个功能分类框架，将合成纳米材料分为(1)靶向药物递送系统，(2)纳米颗粒-水凝胶混合系统和(3)刺激响应功能纳米颗粒，有效地解决了传统分类中的重叠问题。此外，生物源性纳米材料——包括外泌体、细胞膜包被系统和脱细胞细胞外基质（ECM）支架——因其先天的生物相容性、免疫逃避和生物活性而受到重视。这些生物纳米材料与先进的技术如基因工程和组合疗法协同作用，以增强神经修复。特别是，我们首次系统地比较了来自不同组织（如脊髓、视神经、坐骨神经）的去细胞支架的微观结构差异及其引导轴突再生的机制。尽管临床前结果很有希望，但在实验模型和临床应用之间仍然存在标准化、可扩展生产和长期生物安全性等挑战。未来的发展方向是动态响应、多功能组合设计和与再生医学范例的结合，以实现SCI管理中的功能恢复。

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引用次数: 0

Corrigendum to “Redox-driven mechanoregulation of invasive TNBC cells using poly(tannic acid) nanospheres” [Nano Today, 66 (2026), 102907] “使用聚单宁酸纳米球对侵袭性TNBC细胞的氧化还原驱动的机械调节”的勘误表[Nano Today， 66 (2026), 102907]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-10-18 DOI: 10.1016/j.nantod.2025.102917

Minhee Ku , Suhui Jeong , Nara Yoon , Hwain Myeong , Jinwon Kwon , Jaemoon Yang , Sungbaek Seo

引用次数: 0

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