Nano Today最新文献_第8页

Phosphatidylserine decorated inhalable immunostimulants to eradicate pulmonary metastasis through alveolar macrophage polarization and phagocytosis restoration in situ

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-13 DOI: 10.1016/j.nantod.2025.102667

Xiayun Chen , Qianqian Liu , Baixue Yu , Yi Cen , Yibin Liu , Youzhi Tang , Ning Guo , Tao Wang , Shiying Li

Pulmonary metastasis is frequently observed across various malignant tumors, contributing to a considerable mortality and featuring with a low immune response rate. In this work, a pathological analysis of the pulmonary metastasis indicates that alveolar macrophages (AMs) are prone to be polarized into immunosuppressive M2 phenotype, and the drug screening confirms that TLR7/8 agonists (R848) and SHP2 inhibitor (SHP099) would polarize AMs into immune-promoting M1 phenotype and restore their phagocytic elimination behavior. Based on these discovery, Inhalable and Alveolar Macrophage targeted IMmunostimulants (designated as I-AM-IMs) are fabricated by using phosphatidylserine decorated liposomes to co-deliver R848 and SHP099. Nebulization inhalation of I-AM-IMs enables the passive and active targeted drug delivery for AMs resided in lower respiratory tract, promoting AMs polarization and phagocytosis restoration in situ. Meanwhile, phenotype reprogramming of AMs could direct the phagocytic elimination of pulmonary metastatic tumor cells, trigger the release of cytotoxic cytokines and activate CD8 T cell specific anti-tumor immunity. In vitro and in vivo studies demonstrate the superior immunotherapeutic effects of I-AM-IMs to eradicate pulmonary metastasis, which might provide a versatile and effective strategy for localized pulmonary metastasis immunotherapy.

{"title":"Phosphatidylserine decorated inhalable immunostimulants to eradicate pulmonary metastasis through alveolar macrophage polarization and phagocytosis restoration in situ","authors":"Xiayun Chen , Qianqian Liu , Baixue Yu , Yi Cen , Yibin Liu , Youzhi Tang , Ning Guo , Tao Wang , Shiying Li","doi":"10.1016/j.nantod.2025.102667","DOIUrl":"10.1016/j.nantod.2025.102667","url":null,"abstract":"<div><div>Pulmonary metastasis is frequently observed across various malignant tumors, contributing to a considerable mortality and featuring with a low immune response rate. In this work, a pathological analysis of the pulmonary metastasis indicates that alveolar macrophages (AMs) are prone to be polarized into immunosuppressive M2 phenotype, and the drug screening confirms that TLR7/8 agonists (R848) and SHP2 inhibitor (SHP099) would polarize AMs into immune-promoting M1 phenotype and restore their phagocytic elimination behavior. Based on these discovery, Inhalable and Alveolar Macrophage targeted IMmunostimulants (designated as I-AM-IMs) are fabricated by using phosphatidylserine decorated liposomes to co-deliver R848 and SHP099. Nebulization inhalation of I-AM-IMs enables the passive and active targeted drug delivery for AMs resided in lower respiratory tract, promoting AMs polarization and phagocytosis restoration <em>in situ</em>. Meanwhile, phenotype reprogramming of AMs could direct the phagocytic elimination of pulmonary metastatic tumor cells, trigger the release of cytotoxic cytokines and activate CD8 T cell specific anti-tumor immunity. <em>In vitro</em> and <em>in vivo</em> studies demonstrate the superior immunotherapeutic effects of I-AM-IMs to eradicate pulmonary metastasis, which might provide a versatile and effective strategy for localized pulmonary metastasis immunotherapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102667"},"PeriodicalIF":13.2,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Codelivery of fibronectin and rapamycin via bioactive phosphorus dendrimers to ameliorate Alzheimer’s disease through macrophage autophagy, oxidative stress alleviation and polarization modulation

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-12 DOI: 10.1016/j.nantod.2025.102664

Mengsi Zhan , Waicong Dai , Huxiao Sun , Yue Gao , Yu Zou , Regis Laurent , Xiyang Sun , Serge Mignani , Jean-Pierre Majoral , Mingwu Shen , Xiangyang Shi

The primary pathogenic mechanisms underlying neurodegenerative diseases such as Alzheimer’s disease (AD) involve neuroinflammation, oxidative stress and abnormal protein aggregation, while the main challenges facing effective treatment are limited drug targeting capabilities and the blood-brain barrier (BBB) that impedes drug delivery to damaged brain regions. To address these challenges, a nanosystem based on complexes of bioactive per se phosphorus dendrimers (AK-76) with hydroxyl surface groups and protein fibronectin (FN) with both targeting and therapeutic functions that were physically loaded with rapamycin was developed. The resulting R@A/F (R for rapamycin, A for dendrimer, and F for FN) nanocomplexes (NCs) with a size of 187.3 nm demonstrate good stability, cytocompatibility and targeting performance. We show that the R@A/F NCs can cooperatively modulate microglia by lowering reactive oxygen species level, restoring mitochondrial membrane potential, enhancing autophagy, promoting microglia M2 polarization, and suppressing inflammatory cytokine secretion in vitro. With the assistance of dendrimer terminal hydroxyl groups, the R@A/F NCs can cross the BBB and improve cognitive and memory impairments in an AD mouse model by reducing brain inflammation, stimulating autophagy and facilitating Aβ protein degradation. Our study offers a versatile and highly adaptable nanoplatform for advancing the combined treatment of neuroinflammatory diseases, thus representing a significant step forward in addressing the challenges of AD therapy.

{"title":"Codelivery of fibronectin and rapamycin via bioactive phosphorus dendrimers to ameliorate Alzheimer’s disease through macrophage autophagy, oxidative stress alleviation and polarization modulation","authors":"Mengsi Zhan , Waicong Dai , Huxiao Sun , Yue Gao , Yu Zou , Regis Laurent , Xiyang Sun , Serge Mignani , Jean-Pierre Majoral , Mingwu Shen , Xiangyang Shi","doi":"10.1016/j.nantod.2025.102664","DOIUrl":"10.1016/j.nantod.2025.102664","url":null,"abstract":"<div><div>The primary pathogenic mechanisms underlying neurodegenerative diseases such as Alzheimer’s disease (AD) involve neuroinflammation, oxidative stress and abnormal protein aggregation, while the main challenges facing effective treatment are limited drug targeting capabilities and the blood-brain barrier (BBB) that impedes drug delivery to damaged brain regions. To address these challenges, a nanosystem based on complexes of bioactive <em>per se</em> phosphorus dendrimers (AK-76) with hydroxyl surface groups and protein fibronectin (FN) with both targeting and therapeutic functions that were physically loaded with rapamycin was developed. The resulting R@A/F (R for rapamycin, A for dendrimer, and F for FN) nanocomplexes (NCs) with a size of 187.3 nm demonstrate good stability, cytocompatibility and targeting performance. We show that the R@A/F NCs can cooperatively modulate microglia by lowering reactive oxygen species level, restoring mitochondrial membrane potential, enhancing autophagy, promoting microglia M2 polarization, and suppressing inflammatory cytokine secretion <em>in vitro</em>. With the assistance of dendrimer terminal hydroxyl groups, the R@A/F NCs can cross the BBB and improve cognitive and memory impairments in an AD mouse model by reducing brain inflammation, stimulating autophagy and facilitating Aβ protein degradation. Our study offers a versatile and highly adaptable nanoplatform for advancing the combined treatment of neuroinflammatory diseases, thus representing a significant step forward in addressing the challenges of AD therapy.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102664"},"PeriodicalIF":13.2,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical programming for micro- and nanoarchitectonics of 3D/4D-printed thermoelectric materials

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-11 DOI: 10.1016/j.nantod.2025.102658

Keval K. Sonigara , Martin Pumera

Thermoelectric (TE) materials are important for TE devices that enable waste heat/cold harvesting, energy storage, and thermal sensing applications. Although significant development has been made in TE materials discovery, fabrication methods and designs for TE devices and modules remain a challenge. Recently, three-dimensional (3D) and four-dimensional (4D) printing of TE materials have become essential tools for creating efficient module designs with micro- to nano-scale structures while also minimizing waste generation. However, to achieve the desired print properties and TE material architecture from nano–micro to macro, chemical programming is necessary during feed/ink formulation for the printing procedure. In this review, we focused on TE materials and device fabrication progress in view of chemical programming for 3D/4D-printed TE materials. A brief introduction is provided of TE effects, TE materials, chemical programming approaches, and 3D/4D printing methods. We considered various classes of inorganic, carbon, and polymer-based TE materials to unveil the chemical programming approaches developed to print them. It was found that a significant gap exists in the transition from 3D to 4D printing of TE materials, which could be game-changing for smart applications of TE devices. Recent attempts of 4D printing suggest that chemically programmed smart material integration in TE devices could lead to success for finite applicable TE platforms. Finally, future perspectives and challenges are explored to identify limitations and possible ways forward. Overall, this review provides fresh insights on chemical programming approaches to implement 3D/4D printing of TE materials.

{"title":"Chemical programming for micro- and nanoarchitectonics of 3D/4D-printed thermoelectric materials","authors":"Keval K. Sonigara , Martin Pumera","doi":"10.1016/j.nantod.2025.102658","DOIUrl":"10.1016/j.nantod.2025.102658","url":null,"abstract":"<div><div>Thermoelectric (TE) materials are important for TE devices that enable waste heat/cold harvesting, energy storage, and thermal sensing applications. Although significant development has been made in TE materials discovery, fabrication methods and designs for TE devices and modules remain a challenge. Recently, three-dimensional (3D) and four-dimensional (4D) printing of TE materials have become essential tools for creating efficient module designs with micro- to nano-scale structures while also minimizing waste generation. However, to achieve the desired print properties and TE material architecture from nano–micro to macro, chemical programming is necessary during feed/ink formulation for the printing procedure. In this review, we focused on TE materials and device fabrication progress in view of chemical programming for 3D/4D-printed TE materials. A brief introduction is provided of TE effects, TE materials, chemical programming approaches, and 3D/4D printing methods. We considered various classes of inorganic, carbon, and polymer-based TE materials to unveil the chemical programming approaches developed to print them. It was found that a significant gap exists in the transition from 3D to 4D printing of TE materials, which could be game-changing for smart applications of TE devices. Recent attempts of 4D printing suggest that chemically programmed smart material integration in TE devices could lead to success for finite applicable TE platforms. Finally, future perspectives and challenges are explored to identify limitations and possible ways forward. Overall, this review provides fresh insights on chemical programming approaches to implement 3D/4D printing of TE materials.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102658"},"PeriodicalIF":13.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial screening of nanomedicines in patient-derived cancer organoids facilitates efficient cancer therapy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-11 DOI: 10.1016/j.nantod.2025.102665

Jie Liang , Dong-Kun Zhao , Hao-Ming Yin , Tai-Yu Tian , Jian-Kang Kang , Song Shen , Jun Wang

Patient-derived tumor organoids (Pat.-ORG) have emerged as invaluable tools for identifying synergistic drug combinations, including the precise types and proportions of combined drugs, to guide efficacious therapy. However, the variability in pharmacokinetic profiles among different medications can significantly impact the tumor accumulation of the in vitro screened drug regimens, potentially compromising their ultimate in vivo therapeutic efficacy. Given the remarkable capacity of nanocarriers to deliver multiple drugs with diverse physicochemical properties and to harmonize their in vivo metabolic characteristics, we propose leveraging Pat.-ORG-based drug combination screening using nanomedicine to bridge the gap between in vitro and in vivo outcomes that traditional drug screening methods often encounter. In this study, 15 exquisitely engineered nanomedicines were combined at five distinct drug ratios, yielding 525 unique nanomedicine combinations that were rigorously screened using colorectal cancer organoids to identify those exhibiting remarkable synergistic effects. In vivo experiments validated that the selected nanomedicine combinations demonstrated superior antitumor efficacy compared to their free-drug counterparts. Our research underscores the immense potential of integrating organoid modeling with nanomedicine technology to optimize combination treatment screening and advance the development of effective cancer therapies.

{"title":"Combinatorial screening of nanomedicines in patient-derived cancer organoids facilitates efficient cancer therapy","authors":"Jie Liang , Dong-Kun Zhao , Hao-Ming Yin , Tai-Yu Tian , Jian-Kang Kang , Song Shen , Jun Wang","doi":"10.1016/j.nantod.2025.102665","DOIUrl":"10.1016/j.nantod.2025.102665","url":null,"abstract":"<div><div>Patient-derived tumor organoids (Pat.-ORG) have emerged as invaluable tools for identifying synergistic drug combinations, including the precise types and proportions of combined drugs, to guide efficacious therapy. However, the variability in pharmacokinetic profiles among different medications can significantly impact the tumor accumulation of the <em>in vitro</em> screened drug regimens, potentially compromising their ultimate <em>in vivo</em> therapeutic efficacy. Given the remarkable capacity of nanocarriers to deliver multiple drugs with diverse physicochemical properties and to harmonize their <em>in vivo</em> metabolic characteristics, we propose leveraging Pat.-ORG-based drug combination screening using nanomedicine to bridge the gap between <em>in vitro</em> and <em>in vivo</em> outcomes that traditional drug screening methods often encounter. In this study, 15 exquisitely engineered nanomedicines were combined at five distinct drug ratios, yielding 525 unique nanomedicine combinations that were rigorously screened using colorectal cancer organoids to identify those exhibiting remarkable synergistic effects. <em>In vivo</em> experiments validated that the selected nanomedicine combinations demonstrated superior antitumor efficacy compared to their free-drug counterparts. Our research underscores the immense potential of integrating organoid modeling with nanomedicine technology to optimize combination treatment screening and advance the development of effective cancer therapies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102665"},"PeriodicalIF":13.2,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine-learning assisted novel insulation layer stripping technology for upgrading the transparent EMI shielding materials

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-10 DOI: 10.1016/j.nantod.2025.102660

Yilin Hao , Chuyang Liu , Rapkatjan Keram , Huaxin Song , Yujing Zhang , Guangbin Ji

Silver nanowires (AgNW) hold immense potential to be promoted as competitive transparent electromagnetic interference (EMI) shielding materials. To remove the insulating polyvinyl pyrrolidone (PVP) layer on the surface of AgNW, a machine learning prediction framework (MLPF) is proposed to offer guidance for a novel approach to remove insulating layers of AgNW in the films state. The trained machine learning model achieves an R² value of 0.82 on the test set, demonstrating exceptional generalization capabilities. Through experimental validation, the machine-learning assisted stripping process significantly improves the SE values of AgNW film from 20.81 dB to 28.66 dB, representing a percentage improvement of 37.72 % and maintaining high light transmittance of 82 % at 550 nm. Designed framework not only provides a brand new strategy to remove the PVP effectively, but also expands the application of machine learning in the realm of upgrading transparent EMI shielding materials for the first time.

引用次数: 0

Unveiling the exsolution mechanisms and investigation of the catalytic processes of Sr2FeMo0.65Ni0.35O6-δ using in situ transmission electron microscopy

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-08 DOI: 10.1016/j.nantod.2025.102649

Pritam K. Chakraborty , Stephanie E. Wolf , Govind Ummethala , Ansgar Meise , Tobias Mehlkoph , Junbeom Park , Marc Heggen , Amir H. Tavabi , Vaibhav Vibhu , André Karl , Eva Jodat , L.G.J. (Bert) de Haart , Rafal E. Dunin-Borowski , Shibabrata Basak , Rüdiger-A. Eichel

Solid oxide cells (SOCs) are likely to play crucial role in the green energy transition, but their widespread adoption is hindered by degradation issues, particularly catalyst agglomeration. Nanoparticle exsolution in double-perovskite materials offers a promising solution by creating electrode materials with stable metallic nanocatalysts strongly bonded to the parent oxide, mitigating high-temperature agglomeration issues. Thus, understanding the dynamic evolution of microstructure and catalytic behavior in such materials is vital for developing high-performing SOC catalysts. This study utilized a multimodal approach to investigate the dynamics of exsolution in Sr₂FeMo_0.65Ni_0.35O_6-δ (SFM-Ni) and its effect on cell performance. In situ environmental transmission electron microscopy (ETEM), in situ transmission electron microscopy (TEM) coupled with mass spectrometry visualized the formation and the stability of exsolved particles especially at the concave faces of the parent material during chemical conversion of CO from CO₂. Simultaneously, macro-scale cell experiments coupled with electrochemical impedance spectroscopy, and focused ion beam-scanning electron microscopy (FIB-SEM) tomography, apart from verifying the nanoscale observations, provided crucial insights into the correlation between the exsolution process observed at the micro-scale and the overall cell performance. These findings offers valuable insights into the design and optimization of improved electrode materials for SOCs. Understanding the dynamic behavior of exsolved catalysts would help in enhancing the electrochemical performance at both the nano and macro levels, ultimately advancing the field of sustainable energy technologies.

{"title":"Unveiling the exsolution mechanisms and investigation of the catalytic processes of Sr2FeMo0.65Ni0.35O6-δ using in situ transmission electron microscopy","authors":"Pritam K. Chakraborty , Stephanie E. Wolf , Govind Ummethala , Ansgar Meise , Tobias Mehlkoph , Junbeom Park , Marc Heggen , Amir H. Tavabi , Vaibhav Vibhu , André Karl , Eva Jodat , L.G.J. (Bert) de Haart , Rafal E. Dunin-Borowski , Shibabrata Basak , Rüdiger-A. Eichel","doi":"10.1016/j.nantod.2025.102649","DOIUrl":"10.1016/j.nantod.2025.102649","url":null,"abstract":"<div><div>Solid oxide cells (SOCs) are likely to play crucial role in the green energy transition, but their widespread adoption is hindered by degradation issues, particularly catalyst agglomeration. Nanoparticle exsolution in double-perovskite materials offers a promising solution by creating electrode materials with stable metallic nanocatalysts strongly bonded to the parent oxide, mitigating high-temperature agglomeration issues. Thus, understanding the dynamic evolution of microstructure and catalytic behavior in such materials is vital for developing high-performing SOC catalysts. This study utilized a multimodal approach to investigate the dynamics of exsolution in Sr<sub>2</sub>FeMo<sub>0.65</sub>Ni<sub>0.35</sub>O<sub>6-δ</sub> (SFM-Ni) and its effect on cell performance. <em>In situ</em> environmental transmission electron microscopy (ETEM), <em>in situ</em> transmission electron microscopy (TEM) coupled with mass spectrometry visualized the formation and the stability of exsolved particles especially at the concave faces of the parent material during chemical conversion of CO from CO<sub>2</sub>. Simultaneously, macro-scale cell experiments coupled with electrochemical impedance spectroscopy, and focused ion beam-scanning electron microscopy (FIB-SEM) tomography, apart from verifying the nanoscale observations, provided crucial insights into the correlation between the exsolution process observed at the micro-scale and the overall cell performance. These findings offers valuable insights into the design and optimization of improved electrode materials for SOCs. Understanding the dynamic behavior of exsolved catalysts would help in enhancing the electrochemical performance at both the nano and macro levels, ultimately advancing the field of sustainable energy technologies.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102649"},"PeriodicalIF":13.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verteporfin-integrated conductive zwitterionic hydrogels for scarless wound management

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-07 DOI: 10.1016/j.nantod.2025.102659

Xinyue Cao , Minhui Lu , Jinglin Wang , Yu Wang , Yuanjin Zhao

Hydrogels have outstanding values in wound management. Endeavors in this area have been concentrated on the improvement of the inherent functions of hydrogels and the cooperation with effective bioactives, achieving scarless wound therapy. Herein, we develop a novel verteporfin (VP)-integrated conductive zwitterionic [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) (SBMA) hydrogels for promoting wound healing process and prevention scar formation. The hydrogels with VP’s encapsulation are formed through PEDOT:PSS-promoted spontaneous polymerization of SBMA. The obtained dual-conductive hydrogels possess high resilience, desired adhesion, and inherent antibacterial property, making them extremely suitable for treating skin defects through close contact with wound area, infection reduction and lesions’ electrical field enhancement. Additionally, the loaded VP can be constantly released to wound sites and exhibits anti-scarring effect by inhibiting the Yes-Associated Protein activation and collagen deposition. Based on these advantages, our hydrogel patch has been proven to achieve satisfying therapeutic effects for in vivo scarless wound management. Thus, we believe that the proposed VP-integrated conductive SBMA hydrogels are valuable as multifunctional dressings for wound and scar management.

{"title":"Verteporfin-integrated conductive zwitterionic hydrogels for scarless wound management","authors":"Xinyue Cao , Minhui Lu , Jinglin Wang , Yu Wang , Yuanjin Zhao","doi":"10.1016/j.nantod.2025.102659","DOIUrl":"10.1016/j.nantod.2025.102659","url":null,"abstract":"<div><div>Hydrogels have outstanding values in wound management. Endeavors in this area have been concentrated on the improvement of the inherent functions of hydrogels and the cooperation with effective bioactives, achieving scarless wound therapy. Herein, we develop a novel verteporfin (VP)-integrated conductive zwitterionic [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) (SBMA) hydrogels for promoting wound healing process and prevention scar formation. The hydrogels with VP’s encapsulation are formed through PEDOT:PSS-promoted spontaneous polymerization of SBMA. The obtained dual-conductive hydrogels possess high resilience, desired adhesion, and inherent antibacterial property, making them extremely suitable for treating skin defects through close contact with wound area, infection reduction and lesions’ electrical field enhancement. Additionally, the loaded VP can be constantly released to wound sites and exhibits anti-scarring effect by inhibiting the Yes-Associated Protein activation and collagen deposition. Based on these advantages, our hydrogel patch has been proven to achieve satisfying therapeutic effects for <em>in vivo</em> scarless wound management. Thus, we believe that the proposed VP-integrated conductive SBMA hydrogels are valuable as multifunctional dressings for wound and scar management.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102659"},"PeriodicalIF":13.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143306452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversing tumor fibrosis for potentiating chemo-immunotherapy via lactic acid exhaustion by codelivery of bicarbonate and JQ1

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-06 DOI: 10.1016/j.nantod.2025.102657

Taoxing Peng , Yihao He , Xinyue Shao , Han Liu , Lu Yang , Wei Xiong , Xiaoying Jin , Yang Ding , Yongzhuo Huang

Tumor fibrosis imposes a formidable barrier against effective chemo-immunotherapy, typically resulting in limited infiltration of immune cells and poor drug penetration into the tumor. In this study, it was revealed that intratumoral lactic acid exhaustion can relieve tumor fibrosis by suppressing TGF-β pathway. The bicarbonate liposomes loaded with JQ1 (JQ1/NaHCO₃@TLip) was constructed, with surface modification with lactoferrin (LF) that enabled tumor-targeting delivery via binding with LRP-1 receptors. Intratumoral lactic acid can be reduced via both neutralization and epigenetic-metabolism regulation. JQ1/NaHCO₃@TLip was demonstrated to effectively reverse tumor fibrosis, thereby promoting immune cell infiltration, and enhancing deep penetration of both nanomedicine (e.g., liposomal doxorubicin (DOX@Lip)) and protein drugs (e.g., anti-PD-1). Importantly, the combination of low-dose DOX@Lip and JQ1/NaHCO₃@TLip exhibited remarkable efficacy with reducing side toxicity. This combination approach also effectively inhibited tumor recurrence and distant metastasis. Moreover, pretreatment with JQ1/NaHCO₃@TLip showed a synergistic effect on enhancing tumor inhibition efficacy of anti-PD-1 therapy. These findings indicate that JQ1/NaHCO₃@TLip is promising as a nano-adjuvant to enhance chemo-immunotherapy via lactic acid exhaustion.

{"title":"Reversing tumor fibrosis for potentiating chemo-immunotherapy via lactic acid exhaustion by codelivery of bicarbonate and JQ1","authors":"Taoxing Peng , Yihao He , Xinyue Shao , Han Liu , Lu Yang , Wei Xiong , Xiaoying Jin , Yang Ding , Yongzhuo Huang","doi":"10.1016/j.nantod.2025.102657","DOIUrl":"10.1016/j.nantod.2025.102657","url":null,"abstract":"<div><div>Tumor fibrosis imposes a formidable barrier against effective chemo-immunotherapy, typically resulting in limited infiltration of immune cells and poor drug penetration into the tumor. In this study, it was revealed that intratumoral lactic acid exhaustion can relieve tumor fibrosis by suppressing TGF-β pathway. The bicarbonate liposomes loaded with JQ1 (JQ1/NaHCO<sub>3</sub>@TLip) was constructed, with surface modification with lactoferrin (LF) that enabled tumor-targeting delivery via binding with LRP-1 receptors. Intratumoral lactic acid can be reduced via both neutralization and epigenetic-metabolism regulation. JQ1/NaHCO<sub>3</sub>@TLip was demonstrated to effectively reverse tumor fibrosis, thereby promoting immune cell infiltration, and enhancing deep penetration of both nanomedicine (e.g., liposomal doxorubicin (DOX@Lip)) and protein drugs (e.g., anti-PD-1). Importantly, the combination of low-dose DOX@Lip and JQ1/NaHCO<sub>3</sub>@TLip exhibited remarkable efficacy with reducing side toxicity. This combination approach also effectively inhibited tumor recurrence and distant metastasis. Moreover, pretreatment with JQ1/NaHCO<sub>3</sub>@TLip showed a synergistic effect on enhancing tumor inhibition efficacy of anti-PD-1 therapy. These findings indicate that JQ1/NaHCO<sub>3</sub>@TLip is promising as a nano-adjuvant to enhance chemo-immunotherapy via lactic acid exhaustion.</div></div>","PeriodicalId":395,"journal":{"name":"Nano Today","volume":"61 ","pages":"Article 102657"},"PeriodicalIF":13.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143306451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A dual-warhead high-density lipoprotein mimetic nanomedicine simultaneously regulates stromal extracellular matrix and cGAS/STING activation for potent immunotherapy of cancer

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-05 DOI: 10.1016/j.nantod.2025.102656

Weiwei Wu , Xiaoyang Gao , Haina Tian , Haiyun Wei , Zongyao Ding , Qian Ming , Xue Liang , Changlong Wang

Immunotherapy has shown great potential for cancer treatment in the clinic. However, the inherent physical barrier of abundant extracellular matrix (ECM) and the biological barrier of immunosuppressive microenvironment have greatly hindered the intratumoral inﬁltration of eﬀector T cells. Herein, a dual-warhead high-density lipoprotein (HDL) mimetic nanomedicine is constructed that can regulate stromal ECM and cyclic guanosine monophosphate adenosine monophosphate synthase (cGAS)-stimulator of interferon genes (STING) activation for potent immunotherapy of cancer. After coating the HDL-mimetic outer layer and encapsulation of the transforming growth factor beta (TGF-β) receptor inhibitor LY3200882 (LY) on the hollow manganese dioxide nanoparticles loaded with glucose oxidase, the nanomedicine can target the tumor tissue with high efficiency. In the weak acidic tumor microenvironment, LY is released from the nanomedicine and destroys the physical barrier of ECM by inhibition the TGF-β receptor. After being endocytosed by tumor cells, the manganese ion is released and promotes the self-enhanced chemodynamic therapy. The damage-associated molecular patterns release and the cGAS/STING signaling pathway activation together destroy the biological barrier of immunosuppressive microenvironment. This nanomedicine thus shows potent antitumor efficiency on subcutaneous tumor model, tumor metastasis mice model and tumor recurrence mice model, providing a new strategy for amplifying the cancer immunotherapy.

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引用次数: 0

Nanogels: A chemically versatile drug delivery platform

IF 13.2 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2025-02-03 DOI: 10.1016/j.nantod.2025.102645

Luka Blagojevic, Nazila Kamaly

Nanogels are crosslinked polymeric nanoparticles that exhibit characteristics of an ideal vehicle for therapeutics delivery. These nanocarriers are highly tunable due to the ability of using a variety of chemistries and building blocks in their design, facilitating tailoring of their overall size, surface charge, and payload release behavior. Furthermore, nanogels are compatible with a range of payloads such as small molecules and macromolecules. The level of control over drug loading and drug release parameters achievable via nanogels is superior to common nanocarriers due to this platform’s chemical flexibility, which is amenable to bottom-up and fully covalent synthetic approaches. The modular nature of the nanogel platform facilitates many variations in nanoparticle design, resulting in nanomaterials with complex morphologies, hybrid physicochemical properties and responsiveness to environmental stimuli. “Smart” nanogels are capable of triggered release of the encapsulated payload in response to pH modifications, presence of enzymes, temperature fluctuations, and changes in the concentration of reductants and oxidizers in the surrounding milieu, in addition to physical triggers such as heat and light. The bioconjugation of nanogels with targeting elements yields highly selective multifunctional entities with potential for precision drug delivery applications. This review aims at providing a comprehensive summary of chemical synthesis methods for nanogel development for drug delivery applications. Aspects regarding targeting, encapsulation mechanisms and the reactivity of stimuli-responsive nanogels are covered with the intent of giving the reader an insight in the fundamental chemical principles influencing the rational design of nanogels for drug delivery.

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引用次数: 0