Nano Today最新文献_第8页

Silver chalcogenide colloidal quantum dots for NIR-to-MWIR photodetection 用于近红外到mwir光探测的硫系银胶体量子点

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.nantod.2025.102956

Vishwa Bhatt , Abhishek Sharma , Min-Jae Choi

Infrared (IR) photodetectors are key components in modern optoelectronics, empowering applications across telecommunications, medical imaging, environmental monitoring, defense, and consumer electronics. Colloidal quantum dots (CQDs) have become promising semiconductors in response to growing demand for straightforward, affordable, high-performance, and environment-friendly infrared photo-sensing technologies. The growing attention in CQD-based IR photodetectors is because of their solution processability, spectral tunability, and compatibility with silicon-based platforms. Conventional-CQDs based on Pb, Hg, and Cd exhibit excellent performance, but pose usage/disposal challenges in everyday life as well as serious environmental and health risks. At this critical juncture, binary (Ag₂X; X = S, Se, Te) and ternary (AgBiX₂) silver chalcogenide CQDs have gained attention as RoHS-compliant substitutes. For near-to-mid IR detection, silver chalcogenide CQDs offer tunable bandgaps with strong absorption coefficients and favorable optoelectronic characteristics. Review highlights advance in Ag₂X and AgMX₂ CQDs IR photodetectors, examining their integration into photodetectors device-architecture based on their optoelectronic properties. Role of controlled stoichiometry, surface passivation, and interface-engineering in enhancing photodetector performance is emphasized. With global market for CQDs IR photodetectors projected to achieve milestones, this work presents thorough overview of CQD IR photodetectors, encompassing recent advancements, prevailing challenges, and prospective directions for future development.

红外（IR）光电探测器是现代光电子技术的关键部件，为电信、医疗成像、环境监测、国防和消费电子产品的应用提供了支持。胶体量子点（CQDs）已经成为有前途的半导体，以响应对简单，经济，高性能和环保的红外光传感技术日益增长的需求。基于cqd的红外探测器由于其溶液可加工性、光谱可调性以及与硅基平台的兼容性而受到越来越多的关注。基于铅、汞和镉的常规cqds具有优异的性能，但在日常生活中存在使用/处置挑战，并存在严重的环境和健康风险。在这个关键时刻，二元（Ag2X; X = S, Se, Te）和三元（AgBiX2）银硫系CQDs作为符合rohs的替代品受到了关注。对于近中红外探测，硫系银cqd提供了可调谐的带隙，具有强吸收系数和良好的光电特性。综述了Ag2X和AgMX2 CQDs红外光电探测器的进展，根据其光电特性研究了它们与光电探测器器件结构的集成。强调了控制化学计量学、表面钝化和界面工程在提高光电探测器性能方面的作用。随着CQD红外光电探测器的全球市场预计将达到里程碑，本工作对CQD红外光电探测器进行了全面的概述，包括最近的进展，当前的挑战和未来发展的前景方向。

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引用次数: 0

Rational design of extracellular vesicles for targeted drug delivery across physiological barriers 合理设计细胞外囊泡以跨越生理屏障靶向药物递送

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-11-01 DOI: 10.1016/j.nantod.2025.102920

Helna M. Baby , Hengli Zhang , Andrew Selvadoss , Tanvi V. Pathrikar , Ambika G. Bajpayee

Extracellular vesicles (EVs) are naturally secreted, non-nuclear lipid nanostructures by biological sources with intrinsic features such as biocompatibility, low immunogenicity, and the ability to bypass biological barriers. Despite the growing interest in EV research, their biological potential as a versatile drug delivery vehicle has yet to be widely translated for clinical use. Fewer than 3 % of clinical trials involving these cell-free vesicles have utilized them for drug delivery applications. This review elucidates the reasons behind the translational gap through a comprehensive analysis of pharmacokinetic and tissue transport challenges faced by EVs across various tissue barriers, including the cartilage, blood-brain interface, ocular, gastrointestinal, and skin tissues, and summarizes their endogenous roles within these tissue microenvironments. The review also delves into key engineering design principles, presenting a portfolio of both tissue-specific and tissue-independent targeting strategies to overcome tissue barriers and enhance the precise delivery of engineered EVs. A comprehensive comparison of key factors – such as biodistribution, cellular uptake, intracellular fate, and safety profile – between EVs and benchmark synthetic platforms is also provided to guide the selection of optimal carrier designs for diverse tissue targets and further highlights the steps needed to bridge translational gaps of engineered EVs from a clinical perspective. In conclusion, the review underscores the significance of engineered EVs as a promising next-generation nanocarrier for precision nanomedicine, offering an alternative to conventional synthetic platforms.

细胞外囊泡（EVs）是由生物来源自然分泌的非核脂质纳米结构，具有生物相容性、低免疫原性和绕过生物屏障的能力等固有特征。尽管对EV研究的兴趣日益浓厚，但其作为多功能药物传递载体的生物学潜力尚未广泛转化为临床应用。在涉及这些无细胞囊泡的临床试验中，利用它们进行药物输送的比例不到3% %。本文通过对ev在各种组织屏障（包括软骨、血脑界面、眼、胃肠道和皮肤组织）中所面临的药代动力学和组织运输挑战的综合分析，阐明了翻译差距背后的原因，并总结了它们在这些组织微环境中的内源性作用。该综述还深入探讨了关键的工程设计原则，提出了一系列组织特异性和组织无关的靶向策略，以克服组织障碍，提高工程电动汽车的精确交付。本文还对电动汽车和基准合成平台之间的关键因素（如生物分布、细胞摄取、细胞内命运和安全性）进行了全面比较，以指导针对不同组织靶点的最佳载体设计的选择，并进一步强调了从临床角度弥合工程电动汽车翻译差距所需的步骤。总之，该综述强调了工程化电动汽车作为精密纳米医学的下一代纳米载体的重要性，为传统合成平台提供了一种替代方案。

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引用次数: 0

Corrigendum to “Nanosynergist-engineered oncolytic adenovirus enhancing immune-virotherapy efficacy for glioblastoma via interrupting antiviral responses” [Nano Today 57 (2024) 102328] “纳米增效剂工程溶瘤腺病毒通过中断抗病毒反应增强胶质母细胞瘤的免疫病毒治疗效果”的更正[Nano Today 57 (2024) 102328]

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1016/j.nantod.2025.102970

Jinliang Xu , Xiaoxiao Liu , Junqiang Ding , Hanchang Zhang , Tingting Yao , Sha Li , Rong Yang , Nianhui Yu , Qi Yue , Changyou Zhan , Xihui Gao

引用次数: 0

Biodegradable multimodal biomaterials with microenvironmental adaptability and orderly delivery of H2S and bFGF for the treatment of spinal cord injury 具有微环境适应性和有序输送H2S和bFGF的可生物降解多模态生物材料用于脊髓损伤的治疗

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nantod.2025.102890

Junqing Huang , Jiamen Shen , Yu Huang , Yanfang Zhao , Yibo Ying , Yanran Bi , Liuxi Chu , Xinwang Ying , Qian Xu , Junpeng Xu , Ping Wu , Jiansong Ji , Zhouguang Wang

Spinal cord injury (SCI) is a complex and interactive process involving multiple pathological stages. Single-type biomaterials often struggle to rapidly adapt to the imbalanced regenerative microenvironment and orderly resolve the symptoms of different stages, resulting in slow neural regeneration and limited functional recovery. Herein, we developed a microenvironment- adaptive and time-adaptive multimodal biomaterial (custom-designed with silk fibroin hydrogel-SF and endogenous stimulus responsive nanomedicine-G@Mn, SF-G@Mn) for the treatment of SCI. Based on pathological signals after SCI, the SF-G@Mn achieves the precise release of drugs that inhibit microenvironment regulation (H₂S and Mn^2 +) and nerve regeneration drugs (basic fibroblast growth factor (bFGF)) under different needs in the early and late stages of secondary SCI through asynchronous release kinetics. In the early stages of inflammation, oxidative stress and hypoxia, Mn²⁺ can continuously decompose H₂O₂ to generate oxygen, and synergistic effects with H₂S can jointly relieve oxidative stress, improve hypoxia and inhibit inflammation, thus comprehensively adjusting the microenvironment that is not conducive to tissue repair. As the injury progresses to a later stage dominated by nerve regeneration, bFGF is slowly released to support axon growth and myelin regeneration, helping to restore the function of the damaged nerve. After this multi-dimensional, orderly and multi-stage treatment, the motor function of the SCI mice was significantly restored. In general, this work provides a pathological signal response, on-demand, orderly release of multi-modal biomaterials of drugs at different pathological stages, to achieve spatio-temporal selectivity and adaptive treatment, and provides a valuable example for the development of personalized medicine in the future.

脊髓损伤是一个复杂的、相互作用的过程，涉及多个病理阶段。单一类型的生物材料往往难以快速适应不平衡的再生微环境，难以有序解决不同阶段的症状，导致神经再生缓慢，功能恢复有限。在此，我们开发了一种微环境自适应和时间自适应的多模态生物材料（定制设计的丝素蛋白水凝胶- sf和内源性刺激响应nanomedicine-G@Mn， SF-G@Mn）用于治疗脊髓损伤。SF-G@Mn以脊髓损伤后的病理信号为基础，通过异步释放动力学实现继发性脊髓损伤早期和晚期不同需求下抑制微环境调节药物（H2S和Mn2 +）和神经再生药物（碱性成纤维细胞生长因子（bFGF））的精准释放。在炎症、氧化应激和缺氧的早期阶段，Mn2+可以不断分解H2O2生成氧气，与H2S协同作用，共同缓解氧化应激、改善缺氧、抑制炎症，从而全面调节不利于组织修复的微环境。随着损伤进展到以神经再生为主的后期，bFGF被缓慢释放以支持轴突生长和髓鞘再生，帮助恢复受损神经的功能。经过这种多维、有序、多阶段的治疗，脊髓损伤小鼠的运动功能得到了明显的恢复。总的来说，本工作提供了病理信号响应，在不同病理阶段按需、有序地释放药物的多模态生物材料，实现时空选择性和适应性治疗，为未来个性化医疗的发展提供了有价值的范例。

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引用次数: 0

Seeing the invisible: Nanoscopy with acoustic AFM 看不见的：声学原子力显微镜的纳米显微镜

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-09-10 DOI: 10.1016/j.nantod.2025.102895

Ye Tian , Biao-Feng Zeng , Jian Chen , Longhua Tang

Acoustic atomic force microscopy (AFM) addresses the limitations of traditional imaging for seeing the invisible subsurface nanofeatures with the advantages of both the noninvasive penetration of ultrasound and the nanoscale resolution of AFM. This review emphasizes key achievements and recent advancements of the acoustic AFM, focusing on improvements in multi-modal excitation, multi-scheme operation, multi-component applications, and multi-parameter imaging. Theoretical algorithms and limitations including amplitude attenuation, frequency shift, phase transition, and energy consumption are analyzed, and discrepancies among models, simulations, and experiments are discussed. The review also examines the applications of acoustic AFM in advanced semiconductor nanodevices, the characterization of functional material properties, and the monitoring of living systems. Results emphasize the potential of integrating ultrasonic AFM with quantum sensing and artificial intelligence to develop refined nanoscale fluctuation models, innovate multi-modal probes, and create high-throughput data processing algorithms. These advancements aim to achieve wide-field, high-throughput, ultra-high spatial-temporal resolution, and real-time dynamic nondestructive monitoring of samples with complex structures and environments, paving the way for the next generation of ultrasonic AFM.

声学原子力显微镜（AFM）具有超声的无创穿透和AFM纳米级分辨率的优势，解决了传统成像技术在观察不可见的亚表面纳米特征方面的局限性。本文综述了声学AFM在多模态激励、多方案操作、多组分应用和多参数成像等方面的主要成就和最新进展。分析了理论算法和局限性，包括幅度衰减、频移、相变和能量消耗，并讨论了模型、仿真和实验之间的差异。本文还探讨了声学AFM在先进半导体纳米器件、功能材料特性表征和生命系统监测中的应用。结果强调了超声AFM与量子传感和人工智能相结合的潜力，可以开发精细的纳米尺度波动模型，创新多模态探针，并创建高通量数据处理算法。这些进步旨在实现对复杂结构和环境样品的宽视场、高通量、超高时空分辨率和实时动态无损监测，为下一代超声AFM铺平道路。

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引用次数: 0

Biomineralization-inspired nanosheet transformation potentiates cancer therapy through precise embolization and antitumor immunity restoration 生物矿化激发的纳米片转化通过精确栓塞和抗肿瘤免疫恢复来增强癌症治疗

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-12-31 DOI: 10.1016/j.nantod.2025.102971

Kangli Guo , Ling Liang , Ying Liu , Xiaoyi Zhao , Bo Zhi Chen , Dandan Sui , Xin Dong Guo , Fu-Jian Xu , Nana Zhao

Tumor vasculature targeting therapy represents a promising approach to inhibit tumor growth by disrupting the supply of nutrients and oxygen. However, achieving tumor-specific embolization remains a great challenge while the severe disruption of the vascular supply is supposed to aggravate tumor immunosuppression. Inspired by natural biomineralization process of magnesium phosphate, we developed a novel approach combining Mg(OH)₂ nanosheets with microneedles (MNs) for precise tumor embolization and enhanced immunotherapy. Triggered by elevated concentrations of hydrogen ions and phosphate in the tumor microenvironment (TME), Mg(OH)₂ nanosheets undergo a transformation into biomineralized magnesium phosphate precipitates for tumor-specific embolization. Furthermore, these nanosheets exhibit intrinsic immunomodulatory properties, capable of reversing immunosuppression by neutralizing the acidic TME. Additionally, they induce dendritic cell maturation and oxidative stress in tumor cells, triggering immunogenic cell death and eliciting robust antitumor immune responses. To further enhance the efficiency, the MN platform enables co-delivery of the antiangiogenic drug sunitinib with Mg(OH)₂ nanosheets. The satisfactory antitumor effects of the Mg(OH)₂-MNs platform in vivo were validated in a 4T1 tumor-bearing mice model. Transcriptomics analysis confirmed the activation of strong antitumor immunity and successful immunosuppression reversal. This study proposes a promising biomineralization-inspired strategy to construct immunomodulatory nanomaterials for tumor-specific embolization and enhanced immunotherapy.

肿瘤血管靶向治疗是一种很有前途的方法，通过破坏营养和氧气的供应来抑制肿瘤的生长。然而，实现肿瘤特异性栓塞仍然是一个巨大的挑战，而血管供应的严重中断可能会加重肿瘤的免疫抑制。受天然磷酸镁生物矿化过程的启发，我们开发了一种将Mg(OH)2纳米片与微针（MNs）结合的新方法，用于精确肿瘤栓塞和增强免疫治疗。在肿瘤微环境（TME）中氢离子和磷酸盐浓度升高的触发下，Mg(OH)2纳米片转化为生物矿化磷酸镁沉淀，用于肿瘤特异性栓塞。此外，这些纳米片表现出固有的免疫调节特性，能够通过中和酸性TME来逆转免疫抑制。此外，它们诱导肿瘤细胞中的树突状细胞成熟和氧化应激，引发免疫原性细胞死亡并引发强大的抗肿瘤免疫反应。为了进一步提高效率，MN平台可以将抗血管生成药物舒尼替尼与Mg(OH)2纳米片共同递送。在4T1荷瘤小鼠模型中验证了Mg(OH)2-MNs平台的体内抗肿瘤效果。转录组学分析证实了强大的抗肿瘤免疫激活和成功的免疫抑制逆转。本研究提出了一种有前途的生物矿化启发策略，构建用于肿瘤特异性栓塞和增强免疫治疗的免疫调节纳米材料。

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引用次数: 0

Manganese in metalloimmunotherapy: From molecular targets to material engineering and translational therapeutics 锰在金属免疫治疗中的应用：从分子靶点到材料工程和转化疗法

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-09 DOI: 10.1016/j.nantod.2025.102967

Jiale Xie , Siqi Wang , Haosen Zhao , Jiali Wang , Jie Liu , Ran Wei , Xudong Wang , Yujing Li

Immunotherapies play a crucial role in maintaining human health by modulating the immune system through the use of immune cells, antibodies, and vaccines. Among emerging therapeutic modalities, metal-based immunotherapy has shown promise by utilizing the immune-modulating properties of metals, metal ions, and metallic compounds for disease intervention. Specifically, Mn^2 + has been demonstrated to potently activate the cGAS/STING signaling axis, a key pathway in innate immune activation for immunotherapeutic strategies. Notwithstanding these advantages, the clinical translation of free Mn²⁺ is substantially hindered by three critical limitations: rapid in vivo degradation, poor transmembrane permeability as a hydrophilic cation, and potential cytotoxicity. To address these bottlenecks, advanced controlled-release technologies have been developed to enable spatiotemporal regulation of Mn²⁺ in biological systems, thus improving therapeutic efficacy and reducing off-target effects. In this review, we delve into the intricate molecular mechanisms by which manganese ions regulate immune responses and explores the cutting-edge technologies employed in the fabrication of manganese-based materials. Then, we discussed the latest research on the use of manganese-based materials in antiviral, antibacterial and anticancer applications. Through its comprehensive comparative analysis, this review seeks to inspire next-generation research in manganese-based immunotherapy, unmasking its transformative potential across interdisciplinary frontiers and thereby catalyzing paradigm shifts in translational medicine.

免疫疗法通过使用免疫细胞、抗体和疫苗来调节免疫系统，在维持人体健康方面起着至关重要的作用。在新兴的治疗方式中，金属基免疫疗法通过利用金属、金属离子和金属化合物的免疫调节特性进行疾病干预，显示出了希望。具体来说，Mn2 +已被证明可以有效激活cGAS/STING信号轴，这是免疫治疗策略先天免疫激活的关键途径。尽管有这些优势，游离Mn2+的临床转化受到三个关键限制的阻碍：体内降解迅速，作为亲水性阳离子的跨膜渗透性差，以及潜在的细胞毒性。为了解决这些瓶颈，先进的控释技术已经被开发出来，可以在生物系统中对Mn2+进行时空调控，从而提高治疗效果，减少脱靶效应。在这篇综述中，我们深入研究了锰离子调节免疫反应的复杂分子机制，并探讨了锰基材料制备的前沿技术。然后，讨论了锰基材料在抗病毒、抗菌和抗癌等方面的最新研究进展。通过全面的比较分析，本综述旨在激发下一代锰基免疫疗法的研究，揭示其跨跨学科前沿的变革潜力，从而催化转化医学的范式转变。

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引用次数: 0

Modulating the inverse VC/Pd heterostructure for high-performance electrocatalytic methanol oxidation 高性能电催化甲醇氧化中VC/Pd逆异质结构的调控

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.1016/j.nantod.2026.102986

Ting Wu , Haolin Li , Wei Zhang , Jie Liu , Junning Zhao , Jialin Zhao , Shuangfei Cai , Rong Yang , Zhiyong Tang

Design of effective methanol oxidation reaction (MOR) electrocatalysts with fast reaction kinetics and exceptional CO resistance remains a grand challenge. Herein, we report an electron-restructuring strategy based on an inverse interfacial structure, by decorating the vanadium carbide nanoclusters (VC NCs) on hexagonal Pd nanosheets (NSs) for efficient MOR. The VC-decorated Pd NSs evolve into unique mulberry leaf-like structures (NMLs) with the jagged edges, enhancing active sites exposure and interfacial charge transfer. The VC_0.01/Pd NMLs exhibit high mass activity (1768.44 A g_Pd⁻¹), 23.6 and 6.4 times higher than Pd NSs and commercial Pd/C catalyst, respectively. The VC_0.01/Pd NMLs also show high tolerance to CO poisoning. Theoretical calculations further reveal a strong VC-Pd interfacial interaction, modulating the Pd’s d-band center, reducing CO* adsorption, and enhancing OH* generation. The work shows that the construction of inverse VC-Pd interfaces is an effective approach to improve electrocatalytic performance of Pd catalysts for MOR.

设计高效的甲醇氧化反应（MOR）电催化剂，具有快速反应动力学和优异的CO抗性，仍然是一个巨大的挑战。在此，我们报道了一种基于逆界面结构的电子重组策略，通过在六边形钯纳米片（NSs）上装饰碳化钒纳米团簇（VC - NCs）来实现高效的MOR。vc修饰的Pd NSs形成独特的桑叶状结构（NMLs），边缘呈锯齿状，增强了活性位点的暴露和界面电荷转移。VC0.01/Pd NMLs具有较高的质量活性（1768.44 A gPd−1），分别是Pd NSs和商用Pd/C催化剂的23.6倍和6.4倍。VC0.01/Pd的NMLs对CO中毒也表现出较高的耐受性。理论计算进一步揭示了VC-Pd的强界面相互作用，调节了Pd的d波段中心，减少了CO*的吸附，增强了OH*的生成。研究表明，构建VC-Pd逆界面是提高Pd催化剂MOR电催化性能的有效途径。

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引用次数: 0

A magnetic hyperthermia-chemodynamic nanoreactor with ascorbic acid-enhanced reactive oxygen species regulation for anti-thrombosis therapy 抗坏血酸增强活性氧调控的磁热化学动力学纳米反应器用于抗血栓治疗

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.nantod.2025.102951

Xuejiao Gong, Mengyun Yang, Xian Zheng, Hanyang Li, Guohao Li, Chendong Ji, Meizhen Yin

The synergy of reactive oxygen species (ROS) and heat has shown promise in enhancing thrombolysis by disrupting fibrin structure. However, precise control over the spatiotemporal distribution and dosage of ROS and heat at deep thrombus sites remains challenging. Here, we report an ascorbic acid (AA)-enhanced magnetic hyperthermia-chemodynamic therapy (MH-CDT) that exploits the concentration-dependent dual functionality of AA for precision thrombolysis. A dual-targeted magnetic nanoreactor (CMPV) was engineered to rapidly accumulate at the thrombus site via magnetic guidance and platelet membrane coating. AA facilitates the Fenton reaction for enhanced ROS generation to dissolve fibrin, while subsequently neutralizing excessive ROS to suppress inflammation during vascular repair. MH-CDT demonstrated thorough thrombus clearance and vascular recovery within 24 h without thrombosis recurrence in a mouse carotid artery thrombosis model. The combination between magnetic hyperthermia-induced fibrin disruption and AA-mediated ROS modulation enabled efficient thrombolysis while minimizing detrimental effects on the vascular endothelium. This AA-enhanced MH-CDT system provides a precise and effective thrombolytic strategy that overcomes depth limitations, showing promise for clinical translation.

活性氧（ROS）和热的协同作用已显示出通过破坏纤维蛋白结构来增强溶栓的希望。然而，精确控制血栓深部ROS和热量的时空分布和剂量仍然具有挑战性。在这里，我们报道了一种抗坏血酸（AA）增强磁热化学动力学治疗（MH-CDT），利用AA的浓度依赖的双重功能进行精确溶栓。设计了一种双靶向磁性纳米反应器（CMPV），通过磁引导和血小板膜涂层在血栓部位快速积聚。AA促进Fenton反应，增强ROS生成，溶解纤维蛋白，随后中和过多的ROS，抑制血管修复过程中的炎症。在小鼠颈动脉血栓形成模型中，MH-CDT在24 h内血栓清除彻底，血管恢复，无血栓复发。磁热诱导的纤维蛋白破坏和aa介导的ROS调节的结合使有效的溶栓成为可能，同时最大限度地减少对血管内皮的有害影响。这种aa增强的MH-CDT系统提供了一种精确有效的溶栓策略，克服了深度限制，显示出临床转化的希望。

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引用次数: 0

Curcuma aromatica derived single-atom carbon dots with microenvironment responsible multi-enzyme activity for infected diabetic wound regeneration 姜黄衍生的单原子碳点微环境对糖尿病感染伤口再生的多酶活性有影响

IF 10.9 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Today

Pub Date : 2026-02-01 Epub Date: 2026-01-17 DOI: 10.1016/j.nantod.2026.102982

Xiaoqin Hu , Shuyao Liu , Lanling Dai , Rui Wen , Bin Luo , Fang Lan , Yao Wu

The poor healing of diabetic wounds is attributed to infection, oxidative stress, and inflammation, representing a substantial clinical burden. Conventional nanozyme therapies are often constrained by inefficient catalytic cascades due to antagonistic or competitive interference. To overcome these limitations, we have developed a nanozyme composed of herb-derived carbon dots loaded with Fe single atoms (Fe SA@CDs) with the capability of mimicking multi-enzyme activity for ROS elimination and ROS generation in a pH-dependent manner, enabling an "intelligent switching" therapeutic function. Under acidic conditions, it displays NIR light-enhanced POD-like activity (up to 656.6 U/mg) to generate ROS for antibacterial applications. In neutral environment, it exhibits SOD-like activity (up to 2341.9 U/mg) and CAT-like activity to eliminate endogenous ROS for reducing oxidative stress and alleviating inflammation. In vivo experiments show that Fe SA@CDs can dynamically adjust its treatment strategy based on the pH changes in microenvironment: exerting strong antibacterial effects in the early acidic stage, shifting towards anti-inflammatory and regenerative functions in the neutral middle and late stages, thereby achieving a wound healing rate of 92.3 % on day 14. This study demonstrates a smart and microenvironment-responsive nanocatalytic therapy strategy for infected diabetic wound treatment.

糖尿病伤口愈合不良的原因是感染、氧化应激和炎症，这是一个巨大的临床负担。由于拮抗或竞争干扰，传统的纳米酶疗法常常受到低效催化级联反应的限制。为了克服这些限制，我们开发了一种纳米酶，由负载铁单原子的草药衍生碳点组成（Fe SA@CDs），具有模仿多酶活性的能力，以ph依赖的方式消除ROS和生成ROS，实现“智能开关”治疗功能。在酸性条件下，它显示出近红外光增强的pod样活性（高达656.6 U/mg），产生ROS用于抗菌应用。在中性环境下表现出sod样活性（高达2341.9 U/mg）和cat样活性，能够消除内源性ROS，降低氧化应激，缓解炎症。体内实验表明，Fe SA@CDs可以根据微环境pH值的变化动态调整其治疗策略，在酸性早期发挥较强的抗菌作用，在中性中后期转向抗炎和再生功能，从而在第14天达到92.3 %的创面愈合率。本研究展示了一种智能和微环境响应的纳米催化治疗策略，用于治疗感染的糖尿病伤口。

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引用次数: 0