Science Bulletin最新文献

英文中文

Integrative scATAC-seq and mtDNA mutation analysis reveals disease-driven regulatory aberrations in AML scATAC-seq和mtDNA突变分析揭示了AML中疾病驱动的调控畸变。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.07.009

Chen Tian , Yijun Dong , Xin Sun , Longchen Xu , Xiaoli Ma , Yuwei Tao , Fang Wang , Haohang Zhang , Jie Li , Kun Li , Yasong Chen , Hongxing Liu , Xun Lan

Disturbances in transcriptional regulation during hematopoiesis can lead to aberrant hematopoietic differentiation and potential leukemogenesis. Given the high relapse risk of acute myeloid leukemia (AML), understanding its progression mechanisms and identifying prognostic biomarkers are crucial for improving treatment outcomes. Here, we applied a mitochondrial single-cell assay for transposase-accessible chromatin with sequencing mitochondria single-cell ATAC-seq (mtscATAC-seq), supplemented with single-cell RNA-seq, to comprehensively characterize AML cells. By constructing a single-cell hematopoiesis reference and mapping tumor cells to it, we identified significant alterations in chromatin accessibility of cis-regulatory elements (CREs) associated with AML differentiation. Using an in-house developed algorithm, cisGRN, we analyzed CRE dynamics and discovered that mutations in the zinc finger domain of WT1 are associated with decreased chromatin accessibility and hypermethylation at the regulatory regions of their target genes, leading to gene downregulation. Functional validation confirmed the pathogenic effects of five WT1 zinc finger mutations: R467Q, R467L, R467W, H470Y, and H470R. Additionally, we identified a CRE mutation that emerges early in hematopoiesis, introducing a new binding motif for CCAAT enhancer binding protein beta (CEBPB), which facilitates its binding to the enhancer, activating enhancer activity and GATA binding protein 4 (GATA4) expression, thereby promoting AML proliferation. These effects were validated through luciferase reporter assays and prime editing experiments. Using mitochondria DNA tracing and machine learning modeling, we identified relapse-associated clones resembling leukemia stem cells (LSCs) and uncovered marker genes in the clones that more accurately predict drug resistance and relapse risk. Collectively, our findings underscore the utility of combining mtscATAC-seq, lineage tracing, and gene regulatory network (GRN) analysis to uncover aberrant regulatory changes and track relapse-prone AML clones.

造血过程中转录调控的紊乱可导致造血分化异常和潜在的白血病发生。鉴于急性髓性白血病（AML）的高复发风险，了解其进展机制和确定预后生物标志物对于改善治疗结果至关重要。在这里，我们应用线粒体单细胞ATAC-seq （mtscATAC-seq）测序线粒体转座酶可及染色质的线粒体单细胞检测，并辅以单细胞RNA-seq，全面表征AML细胞。通过构建单细胞造血参考并定位肿瘤细胞，我们发现了与AML分化相关的顺式调控元件（CREs）的染色质可及性的显著改变。使用内部开发的cisGRN算法，我们分析了CRE动态，发现WT1锌指结构域的突变与靶基因调控区域的染色质可及性降低和高甲基化相关，导致基因下调。功能验证证实了5个WT1锌指突变R467Q、R467L、R467W、H470Y和H470R的致病作用。此外，我们发现了一个在造血早期出现的CRE突变，为CCAAT增强子结合蛋白β (CEBPB)引入了一个新的结合基序，该基序促进其与增强子结合，激活增强子活性和GATA结合蛋白4 （GATA4）表达，从而促进AML增殖。这些效应通过荧光素酶报告基因检测和引物编辑实验得到验证。利用线粒体DNA追踪和机器学习建模，我们发现了类似白血病干细胞（LSCs）的复发相关克隆，并发现了克隆中更准确地预测耐药性和复发风险的标记基因。总的来说，我们的研究结果强调了结合mtscATAC-seq、谱系追踪和基因调控网络（GRN）分析来发现异常调控变化和跟踪易复发的AML克隆的实用性。

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引用次数: 0

AI-tracked halving of global land carbon sink in 2024. 人工智能追踪到2024年，全球陆地碳汇将减半。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.10.015

Heyuan Wang, Kai Wang, Tao Wang, Zhe Jin, Hanzhi Deng, Yanchen Gui, Wei Chen, Yilong Wang, Xiangjun Tian, Tengjiao Wang

引用次数: 0

Global burden of non-communicable diseases attributable to behavioral factors 可归因于行为因素的全球非传染性疾病负担。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.08.037

Mengmeng Zhu , Shihan Xu , Yiwen Li , Wenting Wang , Longkun Liu , Qian Xu , Jing Cui , Yanfei Liu , Yue Liu

引用次数: 0

Diradical self-assembled monolayers for perovskite photovoltaics 钙钛矿光伏电池用双自由基自组装单层膜。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.08.013

Anand S. Subbiah, Stefaan De Wolf

引用次数: 0

A copper-based single-atom material effectively controls plant diseases with nearly zero soil residue and low phytotoxicity 一种铜基单原子材料，能有效防治植物病害，土壤残留几乎为零，植物毒性低。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.08.018

Rui Huang , Yong Yan , Yafei Jiang , Chunyan Gu , Zhentao Ma , Lifang Xue , Yao Ma , Xingen Lin , Juan Zhang , Ran Shi , Yiwen Wang , Linjing Liu , Chenhui Yang , Xiaoping Gao , Bo Yu , Peigen Liu , Wanyu Shen , Haoran Zhang , Cai Chen , Xin Wang , Yuen Wu

A growing population necessitates the development of sustainable agriculture, which requires achieving atom economy in pesticide delivery, fertilization, and so on. To this end, we focus on single-atom materials (SAMs) to enhance atom utilization within agricultural systems. In this study, we report a novel pesticide for plants, a single-atom copper (Cu₁) formulation, by employing a precipitation-equilibrium-driven (K_sp-driven) method to anchor Cu₁ onto a calcium carbonate (CaCO₃) carrier. Thanks to its high atom dispersion and utilization efficiency, the Cu₁ formulation (Cu₁/CaCO₃) significantly enhances crop disease resistance while exhibiting minimal phytotoxicity in the tested species. Notably, this formulation leads to nearly 20-fold less copper residue in the soil after field application compared to traditional copper formulations. It inhibits microbial growth potentially by targeting key bacterial membrane components through interactions with phosphate groups (–PO₄^2–) in membrane phospholipids and binding to sulfhydryl (–SH) residues in respiratory chain proteins. Cu₁/CaCO₃ represents SAMs as a promising tool for designing green pesticides to manage crop diseases and a novel interdisciplinary approach to promoting sustainable agriculture.

不断增长的人口要求发展可持续农业，这就要求在农药投放、施肥等方面实现原子经济。为此，我们将重点放在单原子材料（sam）上，以提高农业系统中的原子利用率。在这项研究中，我们报告了一种新的植物农药，单原子铜（Cu1）配方，采用沉淀平衡驱动（ksp驱动）方法将Cu1锚定在碳酸钙（CaCO3）载体上。由于其高原子分散性和利用效率，Cu1/CaCO3配方（Cu1/CaCO3）显著提高了作物的抗病性，同时对被试物种表现出最小的植物毒性。值得注意的是，与传统的铜配方相比，该配方在田间施用后土壤中的铜残留量减少了近20倍。它通过与膜磷脂中的磷酸基团（- po42 -）相互作用以及与呼吸链蛋白中的巯基（- sh）残基结合，潜在地靶向细菌膜的关键成分，从而抑制微生物的生长。Cu1/CaCO3代表了SAMs作为设计绿色农药来管理作物病害的一种有前途的工具和促进可持续农业的一种新的跨学科方法。

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引用次数: 0

Chemically gated ion transport in two-dimensional heterogeneous membranes with ultrahigh metal ion selectivity 具有超高金属离子选择性的二维非均质膜中的化学门控离子传输。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.05.040

Gang Yuan , Junjie Fang , Yukun Sun , Jiaojiao Ma , Hao Wang , Wanqi Zhou , Yu Jiang , Chongyang Yang , Zhihua Zhou , Rong Hu , Mingyang Xia , Konstantin S. Novoselov , Hu Qiu , Sheng Hu

Membranes are of particular importance in maintaining physiological activities, with crucial functions including selective permeation of certain ions. Such ion selectivity is achieved via complex molecular machinery to distinguish ions depending on their local physical–chemical environments, which are triggered by a variety of stimuli. Reproduction of such machinery in solid state systems is desirable for applications such as smart filtration, chemical sensing, and energy conversion, but remains a challenging task. We report regulated ion transport in artificial two-dimensional heterogeneous membranes, where the assembled polyacrylic acid macromolecules on the surface of functionalized graphene oxide membranes behave as a molecular regulator. The membrane exhibits chemically gated ion permeation, with the permeability of bi-valent metal cations tunable in response to the concentration of certain signaling ions. The chemistry gating effect is further found bi-valent ion-specific since it negligibly influences the rapid flow of monovalent metal cations. Molecular dynamics simulations reveal its origin as the high energy barriers required for reconfiguring the anion shells formed around bi-valent cations upon their entry. That also explains the observed mono-/bi-valent ion permeability ratio of up to >10⁴. Our work allows fabricating membranes with implanted biomimetic functions of adaptive permeability and selectivity, governed by the choice of components and their responses to the chemical environments.

膜在维持生理活动方面尤为重要，其关键功能包括某些离子的选择性渗透。这种离子选择性是通过复杂的分子机制来实现的，该机制根据各种刺激触发的局部物理化学环境来区分离子。这种机械在固态系统中的再现对于智能过滤、化学传感和能量转换等应用是理想的，但仍然是一项具有挑战性的任务。我们报道了调控离子在人工二维非均相膜中的传输，其中在功能化氧化石墨烯膜表面组装的聚丙烯酸大分子表现为分子调节剂。膜表现出化学门控离子渗透，双价金属阳离子的渗透率可根据某些信号离子的浓度进行调节。进一步发现化学门效应是双价离子特异性的，因为它对单价金属阳离子的快速流动影响可以忽略不计。分子动力学模拟揭示了它的起源是在双价阳离子进入时形成的阴离子壳重新配置所需的高能量势垒。这也解释了观察到的单/双价离子渗透率比高达bbb104。我们的工作允许制造具有自适应渗透性和选择性的植入仿生功能的膜，通过选择成分及其对化学环境的反应来控制。

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引用次数: 0

Modeling spatial processes of extreme heat impacts on global economy: a multi-scale spatio-temporal approach 极端高温对全球经济影响的空间过程模拟：一个多尺度时空方法。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.07.035

Guanpeng Dong , Hang Zhang , Yansui Liu , Changhong Miao

Rising frequency, intensity, and geographic scope of extreme heat profoundly impede global sustainable economic development. However, existing climate econometric models are limited in capturing the spatial processes through which extreme heat affects the global economy, often resulting in downward-biased estimates of total economic losses. This study develops a novel multi-scale spatio-temporal model that integrates classic multi-level modeling with spatial statistics, explicitly addressing key challenges faced by climate econometrics. A Bayesian Markov chain Monte Carlo simulation algorithm is derived for model implementation. Using this model, we present the first quantitative assessment of the impacts of extreme heat on global economic production and their scale-dependent spatial processes. Our findings reveal that, at the national scale, economic losses caused by input–output economic linkages initially decline slowly, then drop sharply with increasing connectivity, with an inflection point around 0.1. When accounting for spatial propagation effects, a 1 ℃ increase in extreme heat intensity leads to an average loss of 2.54% [0.90%, 4.19%] of annual GDP per capita—substantially higher than estimates assuming economic losses are locally confined. Moreover, the economic impacts of extreme heat exhibit significant spatial heterogeneity, with positive marginal effects detected in colder regions and negative effects in warmer regions, with a turning point around 33.7 ℃. This study offers a new methodology to evaluate the impact of climate change from a multi-scale and spatial perspective.

极端高温的频率、强度和地理范围不断上升，严重阻碍了全球经济的可持续发展。然而，现有的气候计量模型在捕捉极端高温影响全球经济的空间过程方面是有限的，往往导致对总经济损失的估计有向下的偏差。本研究开发了一种新的多尺度时空模型，将经典的多层次建模与空间统计相结合，明确解决了气候计量经济学面临的关键挑战。给出了一种贝叶斯马尔可夫链蒙特卡罗仿真算法。利用该模型，我们首次对极端高温对全球经济生产的影响及其尺度依赖的空间过程进行了定量评估。我们的研究结果表明，在全国范围内，投入产出经济联系造成的经济损失最初缓慢下降，然后随着连通性的增加而急剧下降，拐点在0.1左右。考虑到空间传播效应，极端热强度每增加1℃，将导致人均年GDP的平均损失2.54%[0.90%,4.19%]，大大高于假设经济损失仅限于当地的估计。极端高温的经济影响表现出显著的空间异质性，在寒冷地区存在正边际效应，在温暖地区存在负边际效应，在33.7℃左右出现拐点。该研究为从多尺度和空间角度评价气候变化影响提供了一种新的方法。

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引用次数: 0

Synergistic enhancement of Pt electrocatalyst stability and activity in hydrogen oxidation reaction by polyoxometalate and carbon dot co-boosting 多金属氧酸盐与碳点协同增强氢氧化反应中Pt电催化剂的稳定性和活性。

IF 21.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Bulletin

Pub Date : 2025-10-15 DOI: 10.1016/j.scib.2025.07.033

Fei-Yang Yu , Zhong-Ling Lang , Xian Wang , Jing Sun , Yu-Chen Liu , Hua-Qiao Tan , Jun-Jie Ge , Yang-Guang Li , Zhen-Hui Kang

Pt-based catalysts are prone to oxidation and CO poisoning during the hydrogen oxidation reaction (HOR), leading to deactivation, which has presented significant challenges for the application of proton exchange membrane fuel cells (PEMFC). Here, we propose a dual-protection strategy with the advantages of Pt-polyoxometalates (POMs) and carbon dots (CDs) to synthesize an advanced POMs-CDs based electrocatalyst, Pt-SiW₁₂-CDs, with Pt clusters dispersed on SiW₁₂-CDs substrates. It exhibited exceptional HOR performance, achieving a mass activity of 10.36 A mg_Pt⁻¹ at an overpotential of 50 mV, which is over 54 times greater than that of Pt/C (0.19 A mg_Pt^–1). These catalysts also display impressive stability and CO tolerance. By employing X-ray absorption fine structure (XAFS) spectra, transient photovoltage (TPV), transient potential scanning (TPS), and density functional theory (DFT) calculation, the in-depth investigation suggested the muti-roles of SiW₁₂ and CDs for synergistic enhancement of Pt electrocatalyst stability and activity in HOR process. CDs act as bridges, effectively and rapidly transferring protons and electrons to SiW₁₂ from Pt clusters. CDs can effectively coordinate with Pt, regulating its electronic structure while pre-occupying Pt sites, thus hindering CO adsorption on Pt. The reduced SiW₁₂ efficiently transfers electrons to Pt, inhibiting the oxidation of Pt. Additionally, SiW₁₂ also serves as the driving force, maintaining the rapid progression of the HOR process. The dual-protection strategy provides new ideas and directions for design of efficient and stable heterogeneous catalyst.

pt基催化剂在氢氧化反应（HOR）过程中容易氧化和CO中毒，导致失活，这对质子交换膜燃料电池（PEMFC）的应用提出了重大挑战。本文提出了利用聚金属氧酸盐（POMs）和碳点（CDs）的双重保护策略，合成了一种基于POMs-CDs的先进电催化剂Pt-SiW12-CDs，并将Pt簇分散在SiW12-CDs衬底上。它表现出优异的HOR性能，在过电位为50 mV时达到10.36 a mgPt-1的质量活性，是Pt/C （0.19 a mgPt-1）的54倍以上。这些催化剂还表现出令人印象深刻的稳定性和CO耐受性。通过x射线吸收精细结构（XAFS）光谱、瞬态光电压（TPV）、瞬态电位扫描（TPS）和密度泛函理论（DFT）计算，深入研究了SiW12和CDs在HOR过程中协同增强Pt电催化剂稳定性和活性的多重作用。CDs作为桥梁，有效和快速地将质子和电子从Pt簇转移到SiW12。CDs可以有效地与Pt配合，在预先占据Pt位点的同时调节Pt的电子结构，从而阻碍CO在Pt上的吸附。还原后的SiW12有效地将电子转移到Pt上，抑制Pt的氧化。此外，SiW12还起到了驱动作用，维持了HOR过程的快速进行。双保护策略为设计高效稳定的多相催化剂提供了新的思路和方向。

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