This comprehensive review highlights the potential of carbon nanotubes (CNTs) as versatile nanomaterials in medicine by exploring their numerous therapeutic applications. The synthesis processes for single-walled and multi-walled carbon nanotubes are explored in detail in this article, which includes flame synthesis, arc discharge method, laser ablation, nebulized spray pyrolysis, and chemical vapor deposition method. The article focuses on the unique physiochemical characteristics of CNTs that make them attractive for a range of biological uses, including genetic engineering, infection therapy, antibiotics, antibacterial treatments, and anticancer therapies. This article also examines the potential use of CNTs in tissue regeneration and artificial implantation, as well as their use as medications and drug delivery vehicles. The importance of functionalized carbon nanotubes in improving biological applications- such as tissue engineering and infection treatment-is emphasized in the study. Furthermore, it also discusses the possible drawbacks and toxicity issues related to the application of CNTs, highlighting the need for more studies to guarantee their safety and efficient application in therapeutic contexts.
{"title":"Exploring the potential application of single-walled carbon nanotubes in medical treatment and therapy","authors":"Sandra Ross Olakkengil Shajan , Nandini Markuli Sadashivappa , Devaraj Hanumanthappa , Shivaraj Kumar Walikar , Basavana Gowda Hosur Dinesh , Bandral Sunil Kumar , Selvaraj Kunjiappan , Panneerselvam Theivendren , Santhana Krishna Kumar Alagarsamy , Kumarappan Chidamabaram , Damodar Nayak Ammunje , Parasuraman Pavadai","doi":"10.1016/j.talo.2024.100392","DOIUrl":"10.1016/j.talo.2024.100392","url":null,"abstract":"<div><div>This comprehensive review highlights the potential of carbon nanotubes (CNTs) as versatile nanomaterials in medicine by exploring their numerous therapeutic applications. The synthesis processes for single-walled and multi-walled carbon nanotubes are explored in detail in this article, which includes flame synthesis, arc discharge method, laser ablation, nebulized spray pyrolysis, and chemical vapor deposition method. The article focuses on the unique physiochemical characteristics of CNTs that make them attractive for a range of biological uses, including genetic engineering, infection therapy, antibiotics, antibacterial treatments, and anticancer therapies. This article also examines the potential use of CNTs in tissue regeneration and artificial implantation, as well as their use as medications and drug delivery vehicles. The importance of functionalized carbon nanotubes in improving biological applications- such as tissue engineering and infection treatment-is emphasized in the study. Furthermore, it also discusses the possible drawbacks and toxicity issues related to the application of CNTs, highlighting the need for more studies to guarantee their safety and efficient application in therapeutic contexts.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100392"},"PeriodicalIF":4.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1016/j.talo.2024.100391
Mohamed A. El Hamd , Reem H. Obaydo , Dania Nashed , Mahmoud El-Maghrabey , Hayam M. Lotfy
This review explores sustainable strategies for enhancing the solubility of poorly water-soluble pharmaceutical active ingredients (PAIs), focusing on hydrotropy and co-solvency, while comparing their effectiveness, sustainability, and applicability in analytical chemistry, particularly within the frameworks of green and white analytical chemistry (GAC and WAC). Methods like hydrotropy, co-solvency, solid dispersions, and pH modification are discussed, each with distinct advantages and limitations. Hydrotropy, introduced by Carl A. Neuberg in 1916, enhances solubility without altering a drug's UV measurement range and is known for its eco-friendliness, stability, and scalability. Co-solvency modifies the solvent environment using solvents like ethanol but poses environmental concerns. Hydrotropy is safer and more scalable, though it requires more additives, while co-solvency is cost-effective but presents toxicity and precipitation risks. The environmental and safety benefits of hydrotropic solvents align with global sustainability initiatives like the UN SDGs. A case study comparing two UV methods (one with organic solvents and another with hydrotropic solvents) showed hydrotropy's superiority in sensitivity, stability, and sustainability, achieving a sustainability score of 71 % versus 29 % for methanol. The review also highlights the synergistic effects of multiple hydrotropic agents in improving solubility and drug stability. Overall, hydrotropy, particularly when combined with other solubility-enhancing techniques, represents a promising, sustainable approach for improving PAI solubility, offering significant safety, environmental, and economic benefits over traditional organic solvents.
{"title":"Hydrotropy and co-solvency: Sustainable strategies for enhancing solubility of poorly soluble pharmaceutical active ingredients","authors":"Mohamed A. El Hamd , Reem H. Obaydo , Dania Nashed , Mahmoud El-Maghrabey , Hayam M. Lotfy","doi":"10.1016/j.talo.2024.100391","DOIUrl":"10.1016/j.talo.2024.100391","url":null,"abstract":"<div><div>This review explores sustainable strategies for enhancing the solubility of poorly water-soluble pharmaceutical active ingredients (PAIs), focusing on hydrotropy and co-solvency, while comparing their effectiveness, sustainability, and applicability in analytical chemistry, particularly within the frameworks of green and white analytical chemistry (GAC and WAC). Methods like hydrotropy, co-solvency, solid dispersions, and pH modification are discussed, each with distinct advantages and limitations. Hydrotropy, introduced by Carl A. Neuberg in 1916, enhances solubility without altering a drug's UV measurement range and is known for its eco-friendliness, stability, and scalability. Co-solvency modifies the solvent environment using solvents like ethanol but poses environmental concerns. Hydrotropy is safer and more scalable, though it requires more additives, while co-solvency is cost-effective but presents toxicity and precipitation risks. The environmental and safety benefits of hydrotropic solvents align with global sustainability initiatives like the UN SDGs. A case study comparing two UV methods (one with organic solvents and another with hydrotropic solvents) showed hydrotropy's superiority in sensitivity, stability, and sustainability, achieving a sustainability score of 71 % versus 29 % for methanol. The review also highlights the synergistic effects of multiple hydrotropic agents in improving solubility and drug stability. Overall, hydrotropy, particularly when combined with other solubility-enhancing techniques, represents a promising, sustainable approach for improving PAI solubility, offering significant safety, environmental, and economic benefits over traditional organic solvents.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100391"},"PeriodicalIF":4.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-10DOI: 10.1016/j.talo.2024.100389
Vinod K Ganesan , Chun Hui Tan , Pei Song Chee , Jen Hahn Low , Soon Poh Lee , Eng Hock Lim
Amid the increasing demand for advanced gas sensing technologies, particularly for ammonia gas detection, this study presents an innovative solution for far-field sensing at room temperature. Widely used in various industrial applications, ammonia poses significant environmental and health risks, emphasizing the need for efficient monitoring. Although traditional gas sensing methods effective, they often constrained by high operating temperatures and complex electronic components, limiting their practicality. In response, transparent thin films have emerged as a promising alternative, offering real-time monitoring capabilities. However, existing transparent films often rely on external stimuli for activation, resulting in higher power consumption and degradation over time. This research investigates a transparent thin film composed of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) incorporated with graphene nanoplatelets (GNPs) for far-field ammonia gas sensing. Synthesized through a low-temperature, full-solution approach, the film demonstrates an average transmittance of 76.18 % in visible spectrum. Notably, patterning this film into a single slot antenna exhibits a significant 60 MHz frequency shift at a far-field distance of 12 cm when exposed to 50 ppm of ammonia gas. This significant frequency shift underscores the potential of the developed transparent slot antenna for practical and unobtrusive far-field sensing, advancing transparent gas sensors applications in environmental monitoring and workplace safety.
{"title":"Far-field ammonia gas sensing at room temperature with graphene nanoplatelets-infused PEDOT:PSS transparent thin film","authors":"Vinod K Ganesan , Chun Hui Tan , Pei Song Chee , Jen Hahn Low , Soon Poh Lee , Eng Hock Lim","doi":"10.1016/j.talo.2024.100389","DOIUrl":"10.1016/j.talo.2024.100389","url":null,"abstract":"<div><div>Amid the increasing demand for advanced gas sensing technologies, particularly for ammonia gas detection, this study presents an innovative solution for far-field sensing at room temperature. Widely used in various industrial applications, ammonia poses significant environmental and health risks, emphasizing the need for efficient monitoring. Although traditional gas sensing methods effective, they often constrained by high operating temperatures and complex electronic components, limiting their practicality. In response, transparent thin films have emerged as a promising alternative, offering real-time monitoring capabilities. However, existing transparent films often rely on external stimuli for activation, resulting in higher power consumption and degradation over time. This research investigates a transparent thin film composed of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) incorporated with graphene nanoplatelets (GNPs) for far-field ammonia gas sensing. Synthesized through a low-temperature, full-solution approach, the film demonstrates an average transmittance of 76.18 % in visible spectrum. Notably, patterning this film into a single slot antenna exhibits a significant 60 MHz frequency shift at a far-field distance of 12 cm when exposed to 50 ppm of ammonia gas. This significant frequency shift underscores the potential of the developed transparent slot antenna for practical and unobtrusive far-field sensing, advancing transparent gas sensors applications in environmental monitoring and workplace safety.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"11 ","pages":"Article 100389"},"PeriodicalIF":4.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.talo.2024.100384
Amit Das , Md Abu Huraiya , Vinoth Raj R , Hitoshi Tabata , Sankar Ganesh Ramaraj
This study introduces an innovative photonic crystal fiber (PCF) surface plasmon resonance (SPR) biosensor, notable for its sophisticated design and exceptional performance, utilizing gold as the plasmonic material. The sensor offers an expanded detection range and outstanding sensitivity, operating within a refractive index range of 1.27 to 1.43. It achieves a remarkable wavelength sensitivity of 157,000 nm/RIU with a resolution of 6.37 × 10⁻⁷ RIU and an amplitude sensitivity of 1263 RIU⁻¹ with a resolution of 7.92 × 10⁻⁵ RIU. Additionally, it boasts a figure of merit (FOM) of 1648, underscoring its superior capability in detecting biomolecular interactions. The suggested design is numerically analysed using the finite element method (FEM) of a gold-coated PCF-based SPR sensor designed for detecting changes in the refractive index (RI) within the range of 1.27 to 1.43. This range is related to various biological and chemical samples, including proteins, DNA, and biochemical analytes typically used in biomedical diagnostics and environmental monitoring. The integration of gold plasmonic elements enhances the sensor's sensitivity and stability while extending its detection capabilities across a broader range, allowing for versatile applications in biomedicine, environmental monitoring, and beyond. This research significantly advances optical biosensing technologies by offering a robust platform for high-precision detection across diverse domains. The sensor's advanced design and performance make it an invaluable tool for applications requiring accurate and reliable detection, driving innovations in areas such as biomedical diagnostics, environmental monitoring, food safety, and pharmaceutical quality control.
{"title":"Ultra-sensitive refractive index detection with gold-coated PCF-based SPR sensor","authors":"Amit Das , Md Abu Huraiya , Vinoth Raj R , Hitoshi Tabata , Sankar Ganesh Ramaraj","doi":"10.1016/j.talo.2024.100384","DOIUrl":"10.1016/j.talo.2024.100384","url":null,"abstract":"<div><div>This study introduces an innovative photonic crystal fiber (PCF) surface plasmon resonance (SPR) biosensor, notable for its sophisticated design and exceptional performance, utilizing gold as the plasmonic material. The sensor offers an expanded detection range and outstanding sensitivity, operating within a refractive index range of 1.27 to 1.43. It achieves a remarkable wavelength sensitivity of 157,000 nm/RIU with a resolution of 6.37 × 10⁻⁷ RIU and an amplitude sensitivity of 1263 RIU⁻¹ with a resolution of 7.92 × 10⁻⁵ RIU. Additionally, it boasts a figure of merit (FOM) of 1648, underscoring its superior capability in detecting biomolecular interactions. The suggested design is numerically analysed using the finite element method (FEM) of a gold-coated PCF-based SPR sensor designed for detecting changes in the refractive index (RI) within the range of 1.27 to 1.43. This range is related to various biological and chemical samples, including proteins, DNA, and biochemical analytes typically used in biomedical diagnostics and environmental monitoring. The integration of gold plasmonic elements enhances the sensor's sensitivity and stability while extending its detection capabilities across a broader range, allowing for versatile applications in biomedicine, environmental monitoring, and beyond. This research significantly advances optical biosensing technologies by offering a robust platform for high-precision detection across diverse domains. The sensor's advanced design and performance make it an invaluable tool for applications requiring accurate and reliable detection, driving innovations in areas such as biomedical diagnostics, environmental monitoring, food safety, and pharmaceutical quality control.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100384"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.talo.2024.100383
Ghabriel Honório-Silva , Marco Guevara-Vega , Nagela Bernadelli Sousa Silva , Marcelo Augusto Garcia-Júnior , Deborah Cristina Teixeira Alves , Luiz Ricardo Goulart , Mario Machado Martins , André Luiz Oliveira , Rui Miguel Pinheiro Vitorino , Thulio Marquez Cunha , Carlos Henrique Gomes Martins , Murillo Guimarães Carneiro , Robinson Sabino-Silva
Helicobacter pylori (H. pylori) infection can increase the risk of peptic ulcers and gastric neoplasms. H. pylori detection in gastric epithelial tissue collected by esophagogastroduodenoscopy (EGD) is an invasive, costly, and stands as an invasive and examiner-dependent procedure necessitating suitable sedation. complex execution procedure, reducing access for isolated populations. H. pylori detection by Urea Breath Test (UBT) presents high outlay cost with limited access in low- and middle-income countries. In this context, it is critical to develop novel alternative non-invasive platforms for the portable, fast, accessible through self-collection and reagent-free detection of H. pylori. Here, we used attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) supported by Machine Learning algorithms to identify infrared vibrational modes of H. pylori diluted in human saliva. To perform it, saliva was diluted in 4 different concentrations (108 CFU/mL, 107 CFU/mL, 106 CFU/mL, and 105 CFU/mL) of H. pylori. Then, diluted saliva with or without H. pylori were applied to ATR-FTIR spectroscopy to perform a reagent-free, fast, and sustainable analysis of spectral signatures to identify unique vibrational modes to identify this pathogen. The obtained spectra were applied to Linear Discriminant Analysis (LDA) and Support Vector Machine (SVM) algorithms to perform the H. pylori detection. The results indicate that the method was highly accurate between 108 - 105 CFU/mL, achieving an accuracy of 89 % for 108 CFU/mL, 93 % for 107 CFU/mL, 94 % for 106 CFU/mL, and 85 % for 105 CFU/mL with SVM algorithm. This proof-of-concept study demonstrates the significant potential of a biophotonic platform supported by artificial intelligence for the non-invasive detection of H. pylori in human saliva samples obtained by self-collection, without the use of reagents. The data reveal that this proof-of-concept study has significant potential for the non-invasive detection of H. pylori using a biophotonic platform supported by artificial intelligence without the use of reagents with human saliva samples obtained by self-collection.
{"title":"Development of a novel sustainable, portable, fast, and non-invasive platform based on ATR-FTIR technology coupled with machine learning algorithms for Helicobacter pylori detection in human saliva","authors":"Ghabriel Honório-Silva , Marco Guevara-Vega , Nagela Bernadelli Sousa Silva , Marcelo Augusto Garcia-Júnior , Deborah Cristina Teixeira Alves , Luiz Ricardo Goulart , Mario Machado Martins , André Luiz Oliveira , Rui Miguel Pinheiro Vitorino , Thulio Marquez Cunha , Carlos Henrique Gomes Martins , Murillo Guimarães Carneiro , Robinson Sabino-Silva","doi":"10.1016/j.talo.2024.100383","DOIUrl":"10.1016/j.talo.2024.100383","url":null,"abstract":"<div><div><em>Helicobacter pylori (H. pylori</em>) infection can increase the risk of peptic ulcers and gastric neoplasms. <em>H. pylori</em> detection in gastric epithelial tissue collected by esophagogastroduodenoscopy (EGD) is an invasive, costly, and stands as an invasive and examiner-dependent procedure necessitating suitable sedation. complex execution procedure, reducing access for isolated populations. <em>H. pylori</em> detection by Urea Breath Test (UBT) presents high outlay cost with limited access in low- and middle-income countries. In this context, it is critical to develop novel alternative non-invasive platforms for the portable, fast, accessible through self-collection and reagent-free detection of <em>H. pylori</em>. Here, we used attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) supported by Machine Learning algorithms to identify infrared vibrational modes of <em>H. pylori</em> diluted in human saliva. To perform it, saliva was diluted in 4 different concentrations (10<sup>8</sup> CFU/mL, 10<sup>7</sup> CFU/mL, 10<sup>6</sup> CFU/mL, and 10<sup>5</sup> CFU/mL) of <em>H. pylori.</em> Then, diluted saliva with or without <em>H. pylori</em> were applied to ATR-FTIR spectroscopy to perform a reagent-free, fast, and sustainable analysis of spectral signatures to identify unique vibrational modes to identify this pathogen. The obtained spectra were applied to Linear Discriminant Analysis (LDA) and Support Vector Machine (SVM) algorithms to perform the <em>H. pylori</em> detection. The results indicate that the method was highly accurate between 10<sup>8</sup> - 10<sup>5</sup> CFU/mL, achieving an accuracy of 89 % for 10<sup>8</sup> CFU/mL, 93 % for 10<sup>7</sup> CFU/mL, 94 % for 10<sup>6</sup> CFU/mL, and 85 % for 10<sup>5</sup> CFU/mL with SVM algorithm. This proof-of-concept study demonstrates the significant potential of a biophotonic platform supported by artificial intelligence for the non-invasive detection of <em>H. pylori</em> in human saliva samples obtained by self-collection, without the use of reagents. The data reveal that this proof-of-concept study has significant potential for the non-invasive detection of <em>H. pylori</em> using a biophotonic platform supported by artificial intelligence without the use of reagents with human saliva samples obtained by self-collection.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100383"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.talo.2024.100386
Yi-Hsing Liu , Sheng-Joue Young , Liang-Wen Ji , Yen-Lin Chu , Shoou-Jinn Chang
In this study, an ethanol gas sensor was developed using ZnO nanosheets synthesized through an aqueous solution method, with Ag nanoparticles modified on the surface via chemical reduction to enhance ethanol gas sensing capabilities. We discuss the optimal sensitivity, selectivity, stability and optimal operating temperature conditions of Ag/ZnO samples. The selectivity measurement included methanol, ethanol, isopropanol and propanol, and the results showed that Ag/ZnO sample has the best selectivity for ethanol gas and the best sensitivity to ethanol gas (100 ppm, 28.78) when the device operates at 270 °C compared to ZnO sample (100 ppm, 2.27). The flaky structure of the ZnO nanosheets provides a high surface-to-volume ratio, which is beneficial for gas sensing. The addition of Ag nanoparticles further improves the gas sensor performance due to the Ag nanoparticles can more readily capture electrons. The results indicate that the Ag-modified ZnO nanosheet gas sensor exhibits the highest selectivity, excellent stability, and high responsiveness to ethanol gas compared to the ZnO sensor.
{"title":"High-sensitive ethanol gas sensor using Ag modified ZnO nanosheets","authors":"Yi-Hsing Liu , Sheng-Joue Young , Liang-Wen Ji , Yen-Lin Chu , Shoou-Jinn Chang","doi":"10.1016/j.talo.2024.100386","DOIUrl":"10.1016/j.talo.2024.100386","url":null,"abstract":"<div><div>In this study, an ethanol gas sensor was developed using ZnO nanosheets synthesized through an aqueous solution method, with Ag nanoparticles modified on the surface via chemical reduction to enhance ethanol gas sensing capabilities. We discuss the optimal sensitivity, selectivity, stability and optimal operating temperature conditions of Ag/ZnO samples. The selectivity measurement included methanol, ethanol, isopropanol and propanol, and the results showed that Ag/ZnO sample has the best selectivity for ethanol gas and the best sensitivity to ethanol gas (100 ppm, 28.78) when the device operates at 270 °C compared to ZnO sample (100 ppm, 2.27). The flaky structure of the ZnO nanosheets provides a high surface-to-volume ratio, which is beneficial for gas sensing. The addition of Ag nanoparticles further improves the gas sensor performance due to the Ag nanoparticles can more readily capture electrons. The results indicate that the Ag-modified ZnO nanosheet gas sensor exhibits the highest selectivity, excellent stability, and high responsiveness to ethanol gas compared to the ZnO sensor.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100386"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.talo.2024.100388
Julia Coelho Tagliaferro, Amanda Akemy Komorizono, Natalia Candiani Simões Pessoa, Rayssa Silva Correia, Maria Ines Basso Bernardi, Valmor Roberto Mastelaro
The detection of toxic gases has gained significant attention in recent decades. Among various gas-sensing materials, metal oxide semiconductors (MOS) have emerged as highly promising due to their exceptional physical and chemical properties. However, a major limitation of MOS-based gas sensors is their lack of specificity, as they often respond to multiple gases, complicating the identification of target gases in mixed environments. This challenge can be addressed by combining two or more MOS materials to form a heterojunction, which modifies the electronic structure and enhances selectivity. NiO, a p-type semiconductor, has demonstrated the ability to improve both selectivity and sensor response when combined with ZnO, an n-type semiconductor. In this study, ZnO particles were synthesized via a precipitation method to produce two distinct morphologies: needle- and donut-like. These ZnO particles were subsequently combined with NiO via a hydrothermal reaction to form an n-p heterojunction. The selectivity of the resulting sensors was evaluated against O₃, NO₂, NH₃, and CO gases. The results indicated that ZnO sensors with needle- and donut-like morphologies exhibited high responses to oxidizing gases but lacked adequate selectivity between them. In contrast, the ZnO/NiO donut-like heterostructure demonstrated high selectivity for NO₂ detection.
{"title":"Influence of morphology and heterostructure formation on the NO₂ gas sensing properties of the ZnO-NiO system","authors":"Julia Coelho Tagliaferro, Amanda Akemy Komorizono, Natalia Candiani Simões Pessoa, Rayssa Silva Correia, Maria Ines Basso Bernardi, Valmor Roberto Mastelaro","doi":"10.1016/j.talo.2024.100388","DOIUrl":"10.1016/j.talo.2024.100388","url":null,"abstract":"<div><div>The detection of toxic gases has gained significant attention in recent decades. Among various gas-sensing materials, metal oxide semiconductors (MOS) have emerged as highly promising due to their exceptional physical and chemical properties. However, a major limitation of MOS-based gas sensors is their lack of specificity, as they often respond to multiple gases, complicating the identification of target gases in mixed environments. This challenge can be addressed by combining two or more MOS materials to form a heterojunction, which modifies the electronic structure and enhances selectivity. NiO, a p-type semiconductor, has demonstrated the ability to improve both selectivity and sensor response when combined with ZnO, an n-type semiconductor. In this study, ZnO particles were synthesized via a precipitation method to produce two distinct morphologies: needle- and donut-like. These ZnO particles were subsequently combined with NiO via a hydrothermal reaction to form an n-p heterojunction. The selectivity of the resulting sensors was evaluated against O₃, NO₂, NH₃, and CO gases. The results indicated that ZnO sensors with needle- and donut-like morphologies exhibited high responses to oxidizing gases but lacked adequate selectivity between them. In contrast, the ZnO/NiO donut-like heterostructure demonstrated high selectivity for NO₂ detection.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100388"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carbamazepine-10,11-epoxide (EPX-CBZ) is the main by-product of carbamazepine metabolism in the liver. It has been detected in water samples and biological fluids, causing impacts on human health and aquatic organisms. It couldn't be eliminated via biological treatment methods, so the electrochemical oxidation process appears to be a great option to degrade and remediate it. Different factors, such as the initial concentration of EPX-CBZ, the applied voltage, the sodium chloride dose, and the type of matrix, were assessed during the electrochemical process of EPX-CBZ. The kinetics study and consumption energy were calculated using all selected independent factors. The efficiency of the electrochemical oxidation process was investigated using wastewater samples spiked with carbamazepine-10,11-epoxide. Furthermore, identification and elucidation of the selected by-products were performed using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The obtained results exhibited a good view of the efficiency of the electrochemical oxidation process in the degradation of EPX-CBZ. However, all selected factors were effective in the elimination of compounds, resulting in a removal rate of up to 95 %. Energy consumption ranged between 0.15 and 0.35 Wh/mg at the end of electrolysis under the effects of independent factors. While the parent compound degraded, six by-products were detected and identified at 20 min using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results suggest that the electrochemical oxidation process using graphite as an anode is capable of eliminating the target compound and its by-products under selected conditions.
{"title":"Electrochemical degradation of carbamazepine-10,11-epoxide through a reactive intermediate \"hypochlorite ions\": A case study of monitoring the by-products using LC-TOF/MS","authors":"Zainab Haider Mussa , Haider Falih Shamikh Al-Saedi , Nisreen Jawad Kadhim , Zahraa Haleem Al-Qaim , Fouad Fadhil Al-Qaim , Hesam Kamyab","doi":"10.1016/j.talo.2024.100385","DOIUrl":"10.1016/j.talo.2024.100385","url":null,"abstract":"<div><div>Carbamazepine-10,11-epoxide (EPX-CBZ) is the main by-product of carbamazepine metabolism in the liver. It has been detected in water samples and biological fluids, causing impacts on human health and aquatic organisms. It couldn't be eliminated via biological treatment methods, so the electrochemical oxidation process appears to be a great option to degrade and remediate it. Different factors, such as the initial concentration of EPX-CBZ, the applied voltage, the sodium chloride dose, and the type of matrix, were assessed during the electrochemical process of EPX-CBZ. The kinetics study and consumption energy were calculated using all selected independent factors. The efficiency of the electrochemical oxidation process was investigated using wastewater samples spiked with carbamazepine-10,11-epoxide. Furthermore, identification and elucidation of the selected by-products were performed using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The obtained results exhibited a good view of the efficiency of the electrochemical oxidation process in the degradation of EPX-CBZ. However, all selected factors were effective in the elimination of compounds, resulting in a removal rate of up to 95 %. Energy consumption ranged between 0.15 and 0.35 Wh/mg at the end of electrolysis under the effects of independent factors. While the parent compound degraded, six by-products were detected and identified at 20 min using liquid chromatography-time of flight/mass spectrometry (LC-TOF/MS). The results suggest that the electrochemical oxidation process using graphite as an anode is capable of eliminating the target compound and its by-products under selected conditions.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100385"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143096057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1016/j.talo.2024.100387
Leonardo Daniel Soto-Rodríguez , Nancy Shyrley García-Rojas , Carmelo Hernández-Caricio , Héctor Guillén-Alonso , Alexander DeLuna , Eugenio Mancera , Robert Winkler
The material of storage containers affects the shelf life and the chemical composition of food. Artisanal agave spirits, such as mezcal and bacanora, might be filled into low-cost plastic bottles that compromise product quality. We developed an analytical platform to identify the bottle materials of agave spirits, which employs 3D-printed cartridges, and the robotic platform Open LabBot/Open SprayBot for paper-spray ionization mass spectrometry (PS-MS). The bottle material of 102 fresh samples could be identified with a 2 % error. Samples stored for two years at −20 °C in glass vials still were classified correctly in 76 % of the cases. Therefore, the spirits still appear adulterated for a prolonged time after re-bottling into inert containers. The measurement time is about 30 s/sample. Thus, the 3D-PS-MS strategy can be applied for the high-throughput screening for bottle materials of agave spirits and other alcoholic beverages.
{"title":"High-throughput detection of bottle materials of agave spirits using 3D-printed cartridges for paper-spray ionization mass spectrometry","authors":"Leonardo Daniel Soto-Rodríguez , Nancy Shyrley García-Rojas , Carmelo Hernández-Caricio , Héctor Guillén-Alonso , Alexander DeLuna , Eugenio Mancera , Robert Winkler","doi":"10.1016/j.talo.2024.100387","DOIUrl":"10.1016/j.talo.2024.100387","url":null,"abstract":"<div><div>The material of storage containers affects the shelf life and the chemical composition of food. Artisanal agave spirits, such as mezcal and bacanora, might be filled into low-cost plastic bottles that compromise product quality. We developed an analytical platform to identify the bottle materials of agave spirits, which employs 3D-printed cartridges, and the robotic platform Open LabBot/Open SprayBot for paper-spray ionization mass spectrometry (PS-MS). The bottle material of 102 fresh samples could be identified with a 2 % error. Samples stored for two years at −20 °C in glass vials still were classified correctly in 76 % of the cases. Therefore, the spirits still appear adulterated for a prolonged time after re-bottling into inert containers. The measurement time is about 30 s/sample. Thus, the 3D-PS-MS strategy can be applied for the high-throughput screening for bottle materials of agave spirits and other alcoholic beverages.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100387"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142747037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-19DOI: 10.1016/j.talo.2024.100382
Andisiwe Bangani , Mthokozisi Mnguni , Thollwana Andretta Makhetha , Elisabete Oliveira , José Luis Capelo-Martínez , Carlos Lodeiro , Philiswa Nosizo Nomngongo
The occurrence of antibiotics in water bodies is of concern owing to the serious risk they pose to the environment, water security, aquatic organisms, and human health. In this study, mesoporous silica (MCM-41) nanostructured material was synthesised and characterized by various analytical techniques to determine its morphology and dimension, functional groups, surface charge, and textural properties. The nanostructured MCM-41 was used as an adsorbent in ultrasound-assisted dispersive micro solid-phase extraction (UA-D-µ-SPE) of cefadroxil (CFDX) and cephalexin (CPLX) in water samples. The concentration of the analytes in aqueous solution and real water samples was determined using high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). The developed method for CFDX and CPLX in various water samples exhibited relative linear ranges of 0.1–600 µg/L and 0.1–550 µg/L, respectively, and correlation coefficients ranging from 0.9923–0.9993. Under optimum condition, the UA-D-µ-SPE/HPLC-DAD method displayed low limits of detection (LOD) and quantification (LOQ), with values ranging from 0.02–0.16 µg/L and 0.067–0.53 µg/L, respectively. The investigated intraday and interday accuracy in spiked water samples showed acceptable extraction efficiencies with a range of 73.5–98.1% and a relative standard deviation less than 6.0%. Moreover, the performance of MCM-41 was also assessed for the removal of cephalosporin antibiotics aqueous solutions. The kinetic and isotherm studies revealed that the adsorption process followed pseudo-second order and the Langmuir model, respectively. Furthermore, the maximum adsorption capacities for CFDX and CPLX were 43.2 and 47.8 mg/g. Lastly, the UA-D-µ-SPE/HPLC-DAD method was successfully applied in extracting, preconcentrating, separating and determining CFDX and CPLX in wastewater and surface water samples. These results demonstrated that MCM-41 can be applied in the removal of cephalosporin antibiotics from aquatic environments.
{"title":"MCM-41 based dispersive micro-solid phase extraction of selected cephalosporin antibiotic residues from water samples prior to liquid chromatographic quantification","authors":"Andisiwe Bangani , Mthokozisi Mnguni , Thollwana Andretta Makhetha , Elisabete Oliveira , José Luis Capelo-Martínez , Carlos Lodeiro , Philiswa Nosizo Nomngongo","doi":"10.1016/j.talo.2024.100382","DOIUrl":"10.1016/j.talo.2024.100382","url":null,"abstract":"<div><div>The occurrence of antibiotics in water bodies is of concern owing to the serious risk they pose to the environment, water security, aquatic organisms, and human health. In this study, mesoporous silica (MCM-41) nanostructured material was synthesised and characterized by various analytical techniques to determine its morphology and dimension, functional groups, surface charge, and textural properties. The nanostructured MCM-41 was used as an adsorbent in ultrasound-assisted dispersive micro solid-phase extraction (UA-D-µ-SPE) of cefadroxil (CFDX) and cephalexin (CPLX) in water samples. The concentration of the analytes in aqueous solution and real water samples was determined using high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). The developed method for CFDX and CPLX in various water samples exhibited relative linear ranges of 0.1–600 µg/L and 0.1–550 µg/L, respectively, and correlation coefficients ranging from 0.9923–0.9993. Under optimum condition, the UA-D-µ-SPE/HPLC-DAD method displayed low limits of detection (LOD) and quantification (LOQ), with values ranging from 0.02–0.16 µg/L and 0.067–0.53 µg/L, respectively. The investigated intraday and interday accuracy in spiked water samples showed acceptable extraction efficiencies with a range of 73.5–98.1% and a relative standard deviation less than 6.0%. Moreover, the performance of MCM-41 was also assessed for the removal of cephalosporin antibiotics aqueous solutions. The kinetic and isotherm studies revealed that the adsorption process followed pseudo-second order and the Langmuir model, respectively. Furthermore, the maximum adsorption capacities for CFDX and CPLX were 43.2 and 47.8 mg/g. Lastly, the UA-D-µ-SPE/HPLC-DAD method was successfully applied in extracting, preconcentrating, separating and determining CFDX and CPLX in wastewater and surface water samples. These results demonstrated that MCM-41 can be applied in the removal of cephalosporin antibiotics from aquatic environments.</div></div>","PeriodicalId":436,"journal":{"name":"Talanta Open","volume":"10 ","pages":"Article 100382"},"PeriodicalIF":4.1,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142700963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号