Sergey M. Karpov, I. Vyshlova, Anna I. Klimenko, E. Tkachenko, R. N. Gadaborshev, Akhshar I. Dzutsev
Multiple sclerosis is a serious, potentially disabling disease of the central nervous system that often affecting several areas of the brain and spinal cord at the same time. A large number of patients with this disease have been identified in Russia. The aetiology of multiple sclerosis is still under investigation. Every year, new data emerge on the influence of different factors and their interaction. Modern science is actively studying the mechanisms of multiple sclerosis progression, the role of mitochondria in inflammation and neurodegeneration, as well as the impact of COVID-19 on the possibility of development and progression of multiple sclerosis. In this review, we will consider the impact of the SARS-CoV-2 virus on the course of multiple sclerosis.
{"title":"Multiple sclerosis in the context of the COVID-19 pandemic","authors":"Sergey M. Karpov, I. Vyshlova, Anna I. Klimenko, E. Tkachenko, R. N. Gadaborshev, Akhshar I. Dzutsev","doi":"10.17816/nb115009","DOIUrl":"https://doi.org/10.17816/nb115009","url":null,"abstract":"Multiple sclerosis is a serious, potentially disabling disease of the central nervous system that often affecting several areas of the brain and spinal cord at the same time. A large number of patients with this disease have been identified in Russia. The aetiology of multiple sclerosis is still under investigation. Every year, new data emerge on the influence of different factors and their interaction. Modern science is actively studying the mechanisms of multiple sclerosis progression, the role of mitochondria in inflammation and neurodegeneration, as well as the impact of COVID-19 on the possibility of development and progression of multiple sclerosis. In this review, we will consider the impact of the SARS-CoV-2 virus on the course of multiple sclerosis.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121908439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Mendelevich, Kamil A. Gabutdinov, V. V. Ruzhenkova
The article presents the case of twenty-year-old Artem L., whose clinical picture of the disease was dominated by an overvalued hobby in the form of pathological hoarding. The case was analyzed from the standpoint of highlighting a new diagnosis hording in international psychiatric classifications. Differential diagnosis of hording with schizotypal and obsessive-compulsive disorder, as well as with autism spectrum disorders was carried out. It is concluded that the emergence of a new diagnosis of hoarding requires the formation of new algorithms of diagnostic thinking in psychiatrists and the rejection of interpretations of paradoxical, seemingly pretentious behavior as belonging to the circle of schizophrenic disorders.
{"title":"Hoarding: a new diagnosis against the traditional interpretation. Case of Artem L.","authors":"V. Mendelevich, Kamil A. Gabutdinov, V. V. Ruzhenkova","doi":"10.17816/nb262939","DOIUrl":"https://doi.org/10.17816/nb262939","url":null,"abstract":"The article presents the case of twenty-year-old Artem L., whose clinical picture of the disease was dominated by an overvalued hobby in the form of pathological hoarding. The case was analyzed from the standpoint of highlighting a new diagnosis hording in international psychiatric classifications. Differential diagnosis of hording with schizotypal and obsessive-compulsive disorder, as well as with autism spectrum disorders was carried out. It is concluded that the emergence of a new diagnosis of hoarding requires the formation of new algorithms of diagnostic thinking in psychiatrists and the rejection of interpretations of paradoxical, seemingly pretentious behavior as belonging to the circle of schizophrenic disorders.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130035869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. R. Alibekov, Vitaliy V. Goldobin, Hosiddin F. Yuldashev, E. Klocheva, A. Zuev
BACKGROUND. There are many studies in the literature suggesting that cognitive impairment is more pronounced in patients with myasthenia gravis compared with healthy people, but there is no explanation of the reasons and mechanisms. However, the reverse character the influence of intellectual-mnestic disorders on the course of myasthenia gravis has not been studied enough. AIM. To compare clinical, anamnestiс, laboratory and instrumental data in patients with myasthenia gravis according to the presence or absence of cognitive impairment. MATERIAL AND METHODS. 61 patients with a confirmed diagnosis of myasthenia gravis were divided into 2 groups according to the Montreal cognitive test. Patients scoring 25 or less were assigned to the first group, those scoring 26 points or more to the second group. A comparative assessment was made according to the myasthenia gravis impairment index, age of onset, duration of the disease, duration of hospitalization, severity of myasthenia gravis according to clinical scales, body mass index, electroneuromyography data, levels of antibodies to the acetylcholine receptor and skeletal muscles, and daily doses of the drugs received. RESULTS. In the 1st group, there was a significantly higher score on the Generalised Disorders subscale of the Myasthenia Gravis Impairment Index; the severity of Quantitative myasthenia gravis score was significantly higher in the 1st group than in the 2nd both for the total score and for the Musculoskeletal Lesions subscale. On average, 49 mg more pyridostigmine bromide was required in the first group, while the average body mass index was significantly lower in the first group. CONCLUSION. The presence of a cognitive deficit in patients with myasthenia gravis may worsen the clinical picture of the disease, which should be taken into account by clinicians, especially in elderly patients, who are at increased risk of developing cognitive disorders.
{"title":"The relationship of cognitive impairment and clinical manifestations of myasthenia gravis","authors":"A. R. Alibekov, Vitaliy V. Goldobin, Hosiddin F. Yuldashev, E. Klocheva, A. Zuev","doi":"10.17816/nb115213","DOIUrl":"https://doi.org/10.17816/nb115213","url":null,"abstract":"BACKGROUND. There are many studies in the literature suggesting that cognitive impairment is more pronounced in patients with myasthenia gravis compared with healthy people, but there is no explanation of the reasons and mechanisms. However, the reverse character the influence of intellectual-mnestic disorders on the course of myasthenia gravis has not been studied enough. \u0000AIM. To compare clinical, anamnestiс, laboratory and instrumental data in patients with myasthenia gravis according to the presence or absence of cognitive impairment. \u0000MATERIAL AND METHODS. 61 patients with a confirmed diagnosis of myasthenia gravis were divided into 2 groups according to the Montreal cognitive test. Patients scoring 25 or less were assigned to the first group, those scoring 26 points or more to the second group. \u0000A comparative assessment was made according to the myasthenia gravis impairment index, age of onset, duration of the disease, duration of hospitalization, severity of myasthenia gravis according to clinical scales, body mass index, electroneuromyography data, levels of antibodies to the acetylcholine receptor and skeletal muscles, and daily doses of the drugs received. \u0000RESULTS. In the 1st group, there was a significantly higher score on the Generalised Disorders subscale of the Myasthenia Gravis Impairment Index; the severity of Quantitative myasthenia gravis score was significantly higher in the 1st group than in the 2nd both for the total score and for the Musculoskeletal Lesions subscale. On average, 49 mg more pyridostigmine bromide was required in the first group, while the average body mass index was significantly lower in the first group. \u0000CONCLUSION. The presence of a cognitive deficit in patients with myasthenia gravis may worsen the clinical picture of the disease, which should be taken into account by clinicians, especially in elderly patients, who are at increased risk of developing cognitive disorders.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"204 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124579027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AIM. To discuss the historical traditions, modern approaches and experimental research data of the alienation syndrome, including the phenomena of mental automatism, depersonalization, voices; to comprehend the correlation between the phenomena of alienation and dissociation. RESULTS AND CONCLUSIONS. Data from classical pathopsychological experiments which investigating the psychological structure of the alienation syndrome are analyzed. In the pathopsychological school of B.V. Zeigarnik aspects of the examination situation, including mental tension and presence of errors perceptible to the examinee, were studied as moderators of the dynamics of the KandinskyClerambault syndrome. The role of social evaluation factor as a significant source of strengthening or weakening of symptoms was shown.Manifestations of alienation are often perceived as negative influences exerting power over the individual, controlling, humiliating, insulting or interfering with performance. Auditory hallucinations are not so much an auditory event, a perceptual defect, as a psychosocial dialogic phenomenon embodying internalized, often negative, patterns of social interaction. Contemporary psychotherapies for auditory hallucinations include an understanding of the role of metacognitive strategies, social emotions, negative content, and patterns of voice: interaction.
{"title":"On the psychological structure of alienation syndrome and the mechanisms of negative “voice” content","authors":"O. Sagalakova, D. V. Truevtsev, O. Zhirnova","doi":"10.17816/nb117415","DOIUrl":"https://doi.org/10.17816/nb117415","url":null,"abstract":"AIM. To discuss the historical traditions, modern approaches and experimental research data of the alienation syndrome, including the phenomena of mental automatism, depersonalization, voices; to comprehend the correlation between the phenomena of alienation and dissociation. \u0000RESULTS AND CONCLUSIONS. Data from classical pathopsychological experiments which investigating the psychological structure of the alienation syndrome are analyzed. In the pathopsychological school of B.V. Zeigarnik aspects of the examination situation, including mental tension and presence of errors perceptible to the examinee, were studied as moderators of the dynamics of the KandinskyClerambault syndrome. The role of social evaluation factor as a significant source of strengthening or weakening of symptoms was shown.Manifestations of alienation are often perceived as negative influences exerting power over the individual, controlling, humiliating, insulting or interfering with performance. Auditory hallucinations are not so much an auditory event, a perceptual defect, as a psychosocial dialogic phenomenon embodying internalized, often negative, patterns of social interaction. Contemporary psychotherapies for auditory hallucinations include an understanding of the role of metacognitive strategies, social emotions, negative content, and patterns of voice: interaction.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124112286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article is focused on a critical analysis of the work of I.M. Sechenov Reflexes of the brain and its influence on the development of modern psychology, psychoneurology and psychiatry.
本文主要对谢切诺夫的大脑反射理论及其对现代心理学、精神神经学和精神病学发展的影响进行批判性分析。
{"title":"“Revolutionary” steps to a dead end. To the 160th anniversary of the publication of the article “Reflexes of the brain”","authors":"M. Reshetnikov","doi":"10.17816/nb112809","DOIUrl":"https://doi.org/10.17816/nb112809","url":null,"abstract":"The article is focused on a critical analysis of the work of I.M. Sechenov Reflexes of the brain and its influence on the development of modern psychology, psychoneurology and psychiatry.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121283471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper we carried out a critical analysis of М.М. Reshetnikovs article. The invalidity of the arguments and the inappropriate form of presentation are pointed out.
在本文中，我们对М.М进行了批判性分析。前夕的文章。指出了论证的无效和表述形式的不恰当。
{"title":"Comments on the article of M.M. Reshetnikov “Revolutionary” steps to a dead end. To the 160th anniversary of the publication of the article “Reflexes of the brain”","authors":"M. Zobin","doi":"10.17816/nb113015","DOIUrl":"https://doi.org/10.17816/nb113015","url":null,"abstract":"In this paper we carried out a critical analysis of М.М. Reshetnikovs article. The invalidity of the arguments and the inappropriate form of presentation are pointed out.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"180 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121883855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Following the writer and publicist S. Sontag the opportunities of demetaphorization and demythologization of mental disorders (schizophrenia spectrum) are discussed here. Some specific methods are suggested based on trichotomous concept of human (spirit-soul-body).
{"title":"Illness as a metaphor — a psychiatrist’s view","authors":"B. A. Voskresensky, Ruslan I. Begmatov","doi":"10.17816/nb115239","DOIUrl":"https://doi.org/10.17816/nb115239","url":null,"abstract":"Following the writer and publicist S. Sontag the opportunities of demetaphorization and demythologization of mental disorders (schizophrenia spectrum) are discussed here. Some specific methods are suggested based on trichotomous concept of human (spirit-soul-body).","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125164720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The DSM-5, adopted in 2013, presents an updated list of affective disorders, which opens with a fundamentally new psychiatric diagnosis of a disruptive mood dysregulation disorder. Disruptive mood dysregulation disorder is diagnosed in children and adolescents aged 6 to 18 years and is manifested by chronic severe and persistent irritability or anger, as well as outbursts of anger disproportionate to the cause. It is obvious that the condition of a significant part of children and adolescents with a disruptive mood dysregulation disorder before the appearance of this diagnosis was mistakenly regarded as manifestations of bipolar disorder. The criterion of the fundamental difference between disruptive mood dysregulation disorder and bipolar disorder is the absence of manic or hypomanic in the first of them. Disruptive mood dysregulation disorder is characterized by high comorbidity and is often combined with oppositional defiant disorder, conduct disorder and attention deficit with hyperactivity, as well as anxiety. The course and prognostic significance of a disruptive mood dysregulation disorder, as well as the choice of the most effective methods of pharmacological treatment and psychotherapy require numerous further studies.
{"title":"The new psychiatric dignosis: disruptive mood dysregulation disorder","authors":"A. Portnova, Y. Sivolap","doi":"10.17816/nb114959","DOIUrl":"https://doi.org/10.17816/nb114959","url":null,"abstract":"The DSM-5, adopted in 2013, presents an updated list of affective disorders, which opens with a fundamentally new psychiatric diagnosis of a disruptive mood dysregulation disorder. Disruptive mood dysregulation disorder is diagnosed in children and adolescents aged 6 to 18 years and is manifested by chronic severe and persistent irritability or anger, as well as outbursts of anger disproportionate to the cause. It is obvious that the condition of a significant part of children and adolescents with a disruptive mood dysregulation disorder before the appearance of this diagnosis was mistakenly regarded as manifestations of bipolar disorder. The criterion of the fundamental difference between disruptive mood dysregulation disorder and bipolar disorder is the absence of manic or hypomanic in the first of them. Disruptive mood dysregulation disorder is characterized by high comorbidity and is often combined with oppositional defiant disorder, conduct disorder and attention deficit with hyperactivity, as well as anxiety. The course and prognostic significance of a disruptive mood dysregulation disorder, as well as the choice of the most effective methods of pharmacological treatment and psychotherapy require numerous further studies.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127649990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article is devoted to the analysis of the psychopathological consequences of the COVID-19 epidemic. Particular emphasis is placed on assessing the fact of increased mortality from COVID-19 in patients with schizophrenia and affective disorders. It is concluded that this was influenced by the irrational use of antipsychotics, which contributed to the appearance of diabetes and overweight in patients.
{"title":"What did the COVID-19 epidemic learn psychiatrists?","authors":"V. Mendelevich, F. F. Gatin, R. Khamitov","doi":"10.17816/nb117637","DOIUrl":"https://doi.org/10.17816/nb117637","url":null,"abstract":"The article is devoted to the analysis of the psychopathological consequences of the COVID-19 epidemic. Particular emphasis is placed on assessing the fact of increased mortality from COVID-19 in patients with schizophrenia and affective disorders. It is concluded that this was influenced by the irrational use of antipsychotics, which contributed to the appearance of diabetes and overweight in patients.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114647282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kabysh, S. Prokopenko, M.B. Abdullaev, A. Karpenkova, M. Kuznetsova, A.V. Golikova-Chereshkevich, O. Frolova
BACKGROUND. Currently, the study of the cognitive sphere in COVID-19 is an urgent problem. AIM. To determine the presence of cognitive dysfunction using valid scales MoCA, FAB, clock drawing test and their subscales in patients in the acute period of coronavirus infection, to compare the data of cognitive impairment in different epidemiological waves. MATERIAL AND METHODS. Two groups of subjects were included in the present study. Groups No. 1 and No. 2 are patients infected with COVID-19 in the acute period, complicated by pneumonia. Group No. 1 was hospitalized in the period December 2020 March 2021. Group No. 2 was hospitalized in the period November 2021 January 2022. To study the neuropsychological status, the neuropsychological scales MoCA, FAB, the clock drawing test and their subscales were used. Screening for anxiety and depression and depression was performed using the valid HADS scale. Quantitative data on the normality of the distribution of the sample was tested using the ShapiroWilk test. The MannWhitney test was used to compare unrelated groups. Quantitative data are presented as median and interquartile range Me [P25; P75]. Differences were considered statistically significant at p 0.05. RESULTS. Statistically significant differences were found in the acute period of coronavirus infection complicated by pneumonia and cognitive impairment in both group No. 1 and group No. 2, respectively. In group No. 1 (observation period from December 2020 to March 2021), cognitive impairments were more severe than in group No. 2 (observation period from November 2021 to January 2022). When comparing the subscales of the MoCA test of groups No. 1 and No. 2 upon admission to the hospital, and at discharge in group No. 1, the results of MoCA testing were worse than in group No. 2 according to subscales: attention, speech, memory, indicators were statistically significant (p 0.05). According to the FAB data, in group No. 1, the indicators on admission to the hospital and at discharge were also worse than in group No. 2, highly significant differences were according to the data: fluency of speech, dynamic praxis, simple and complicated choice reaction, grasping reflex study (p 0.001). Anxiety and depression were not found in the study groups. CONCLUSION. With the help of such valid scales as: the clock drawing test, MoCA, FAB and their subscales, the presence of cognitive dysfunction in young and middle-aged patients at different time intervals of observation was proved; in the first group, the violations were more severe than in the group No. 2.
{"title":"The state of cognitive functions in COVID-19 complicated by viral pneumonia in young and middle-aged patients in the period 2020–2022","authors":"S. Kabysh, S. Prokopenko, M.B. Abdullaev, A. Karpenkova, M. Kuznetsova, A.V. Golikova-Chereshkevich, O. Frolova","doi":"10.17816/nb112460","DOIUrl":"https://doi.org/10.17816/nb112460","url":null,"abstract":"BACKGROUND. Currently, the study of the cognitive sphere in COVID-19 is an urgent problem. \u0000AIM. To determine the presence of cognitive dysfunction using valid scales MoCA, FAB, clock drawing test and their subscales in patients in the acute period of coronavirus infection, to compare the data of cognitive impairment in different epidemiological waves. \u0000MATERIAL AND METHODS. Two groups of subjects were included in the present study. Groups No. 1 and No. 2 are patients infected with COVID-19 in the acute period, complicated by pneumonia. Group No. 1 was hospitalized in the period December 2020 March 2021. Group No. 2 was hospitalized in the period November 2021 January 2022. To study the neuropsychological status, the neuropsychological scales MoCA, FAB, the clock drawing test and their subscales were used. Screening for anxiety and depression and depression was performed using the valid HADS scale. Quantitative data on the normality of the distribution of the sample was tested using the ShapiroWilk test. The MannWhitney test was used to compare unrelated groups. Quantitative data are presented as median and interquartile range Me [P25; P75]. Differences were considered statistically significant at p 0.05. \u0000RESULTS. Statistically significant differences were found in the acute period of coronavirus infection complicated by pneumonia and cognitive impairment in both group No. 1 and group No. 2, respectively. In group No. 1 (observation period from December 2020 to March 2021), cognitive impairments were more severe than in group No. 2 (observation period from November 2021 to January 2022). When comparing the subscales of the MoCA test of groups No. 1 and No. 2 upon admission to the hospital, and at discharge in group No. 1, the results of MoCA testing were worse than in group No. 2 according to subscales: attention, speech, memory, indicators were statistically significant (p 0.05). According to the FAB data, in group No. 1, the indicators on admission to the hospital and at discharge were also worse than in group No. 2, highly significant differences were according to the data: fluency of speech, dynamic praxis, simple and complicated choice reaction, grasping reflex study (p 0.001). Anxiety and depression were not found in the study groups. \u0000CONCLUSION. With the help of such valid scales as: the clock drawing test, MoCA, FAB and their subscales, the presence of cognitive dysfunction in young and middle-aged patients at different time intervals of observation was proved; in the first group, the violations were more severe than in the group No. 2.","PeriodicalId":436189,"journal":{"name":"Neurology Bulletin","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123363854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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