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2006 IEEE International Frequency Control Symposium and Exposition最新文献

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Characterization of Extracellular Matrix (ECM) Produced by MC3T3 Cells Using Thickness Shear Mode (TSM) Resonators 利用厚度剪切模式(TSM)谐振器表征MC3T3细胞产生的细胞外基质(ECM)
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275443
Fang Li, Qing-Ming Wang, J.H.-C. Wang
Quartz thickness shear mode (TSM) resonators for monitoring the attachment and spreading of mammalian cells have been investigated in the past years. Recent studies have shown that the TSM resonator signal is not only contributed by cellular body closed to the resonator substrate, but also contributed by the extracellular matrix (ECM), which is a protein layer between the cellular body and the resonator surface. Therefore, the quartz TSM resonator is expected to provide a simple, quantitative and effective method to characterize the ECM produced by cells. In this study, we investigate the use of quartz TSM resonators to monitor the ECM production by cells in real time and to characterize the mechanical properties and the thickness of this protein layer. MC3T3-E1 fibroblasts are chosen in our study because they are an established cell line that is stable in culture from passage to passage and they can produce abundant collagenous matrix within a relatively short culture period. AT-cut quartz crystal resonators coated with gold electrodes on both sides are used in this study. An impedance analyzer is used for measuring the admittance spectra and total parallel capacitance of the resonators. Multilayer model is constructed to characterize the mechanical properties and thickness of the ECM layer by using a curve-fitting method. The results obtained by TSM resonator sensors show a good agreement with those obtained by chemical methods
石英厚度剪切模式(TSM)谐振器用于监测哺乳动物细胞的附着和扩散在过去的几年里进行了研究。近年来的研究表明,TSM谐振器信号不仅由靠近谐振器底物的细胞体贡献,还由细胞体与谐振器表面之间的蛋白质层细胞外基质(extracellular matrix, ECM)贡献。因此,石英TSM谐振器有望提供一种简单、定量和有效的方法来表征细胞产生的ECM。在这项研究中,我们研究了使用石英TSM谐振器实时监测细胞产生的ECM,并表征该蛋白质层的力学特性和厚度。我们之所以选择MC3T3-E1成纤维细胞,是因为MC3T3-E1成纤维细胞是一种成熟的细胞系,在传代培养中稳定,在较短的培养时间内可以产生丰富的胶原基质。在本研究中使用了at切割的石英晶体谐振器,其两侧涂有金电极。用阻抗分析仪测量了谐振器的导纳谱和总并联电容。采用曲线拟合的方法,建立了多层模型来表征ECM层的力学性能和厚度。TSM谐振器传感器的测量结果与化学方法的测量结果吻合较好
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引用次数: 2
Energy-Trapping Torsional-Mode Resonators for Liquid Sensing 用于液体传感的能量捕获扭模谐振器
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275365
M.K. Kang, Rui Huang, T. Knowles
Thickness-shear mode quartz crystal microbalance (QCM) has been widely used as liquid-phase sensors, such as viscometers and bio-detectors. However, due to coupling between the in-plane shear motion and the out-of-plane flexure, when used in contact with or immersed in a liquid, the out-of-plane motion generates compressional waves in the liquid that reflect off the liquid surface and return to the crystal. This interference effect causes depth-sensitive perturbations in the sensor response, often undesirable. In this study, we show that torsional-mode resonators may be used for liquid sensing without the depth effect. Samples in form of stepped plates, circular decals, and convex contoured faces are machined in elastic plates (e.g., cast aluminum, stainless steel, and brass). A non-contact electromagnetic acoustic transducer (EMAT) was employed to drive torsional-mode vibrations. Efficient energy trapping was observed for first-order torsional modes, leading to high quality factors. When placed in contact with water, the resonance frequency of the torsional mode was found to be independent of the water depth, in contrast to depth-dependent frequency oscillation for the thickness-shear mode. Finite element analyses are conducted to understand the torsional-mode vibrations as well as the effect of material anisotropy
厚度-剪切模式石英晶体微天平(QCM)已广泛应用于液相传感器,如粘度计和生物检测器。然而,由于面内剪切运动和面外弯曲之间的耦合,当与液体接触或浸入液体时,面外运动在液体中产生纵波,这些纵波从液体表面反射并返回到晶体中。这种干扰效应在传感器响应中引起深度敏感的扰动,通常是不希望出现的。在这项研究中,我们证明了扭转模谐振器可以用于没有深度效应的液体传感。在阶梯板,圆形贴花和凸轮廓面形式的样品在弹性板(例如,铸铝,不锈钢和黄铜)中加工。采用非接触式电磁声换能器(EMAT)驱动扭振型振动。在一阶扭转模态中观察到有效的能量捕获,从而获得高质量因子。当与水接触时,发现扭转模态的共振频率与水深无关,而厚度-剪切模态的频率振荡则与水深相关。通过有限元分析来了解扭转模态振动以及材料各向异性的影响
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引用次数: 8
Parameters Extraction and Design Optimization for AT-cut Quartz Resonator based on Mindlin's 2D Model 基于Mindlin二维模型的at切割石英谐振器参数提取与设计优化
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275348
S. Pao, M. Chao, T. Wang, D. Chang, C. S. Lam, P.Z. Chang
For miniaturized strip AT-cut quartz resonator, the demand of performance is higher and higher, so the design ability is more important than before. But to get a precise simulation electrical response of the AT-cut quartz plate by a common commercial FEM tool is not easy and time consuming also. Base on Mindlin's (1961) 2D model and Lee-Brebbia's (1978) FEA method, Pao (2004) et al. presented an efficient numerical method in calculating the electrical response different modes of AT-cut strip quartz crystal resonator with electrode. Base on weak coupling of quartz material and mass loading effect of electrode, this problem was solved by separating the mechanical vibration and electrical coupling effects. The method considers not only the pure mechanical vibration but also the electrical response, so different modes can be identified effectively and efficiently. However, to be a practical design tool, the parameters used in the simulation better come from real samples. In this paper, the works was extended to parameters extraction for design optimization. A blank with electrode was built and its acoustic and electrical material parameters (including damping coefficient) of the quartz resonators could be extracted by fitting to few measured sample admittance curves. The extracted parameters could be used for design optimization purpose. To examine the effectiveness of the parameters extraction, another blank with electrode quartz resonator was built and the results showed the calculated impedance curves could match the measured ones, and a practical AT-cut strip quartz resonator design tool could be made based on extended Mindilin's 2D model
对于小型化的条形at切割石英谐振器,其性能要求越来越高,因此设计能力比以往更加重要。但是,用普通的商用有限元工具精确模拟at切割石英石板的电响应并不容易,而且耗时。Pao(2004)等人在Mindlin(1961)二维模型和Lee-Brebbia(1978)有限元分析方法的基础上,提出了一种计算at切割带电极石英晶体谐振器不同模式电响应的有效数值方法。基于石英材料的弱耦合和电极的质量加载效应,将机械振动和电耦合效应分离,解决了这一问题。该方法不仅考虑了纯机械振动,而且考虑了电响应,因此可以有效地识别不同的模态。然而,为了成为一个实用的设计工具,仿真中使用的参数最好来自真实的样品。本文将工作扩展到设计优化的参数提取。建立了带电极的空白电极,通过拟合少量实测样品的导纳曲线,可以提取石英谐振器的声、电材料参数(包括阻尼系数)。提取的参数可用于设计优化。为了验证参数提取的有效性,建立了另一个电极石英谐振器的空白,结果表明,计算得到的阻抗曲线与实测曲线吻合较好,并基于扩展的Mindilin二维模型构建了实用的at切割条形石英谐振器设计工具
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引用次数: 4
ADEV Calculated from Phase Noise Measurements and Its Possible Errors Due to FFT Sampling 从相位噪声测量计算ADEV及其由于FFT采样可能产生的误差
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275452
Do-Cheng Chang, Shang-Shian Chen, Shinn-Yan Lin
In this paper, we show that fast Fourier transform (FFT) sampling plays an important role in the calculation of Allan deviation (ADEV) while using the numerical integration as a tool for the time and frequency (T&F) conversion. In order to avoid generation of unreasonable ADEV values, FFT sampling data are re-generated with logarithmic frequency space using an interpolation skill. Therefore, results from both the numerical integration and the power-law processes could match each other quite well. Besides, spurs in spectral density have non-neglectful influences upon ADEV results. For example, when the data of our lab's phase noise measurement system are processed, the ADEV generated from the spectral density with spurs may reach to three times the one while spurs are removed
在本文中,我们证明了快速傅里叶变换(FFT)采样在计算艾伦偏差(ADEV)中起着重要的作用,同时使用数值积分作为时间和频率(T&F)转换的工具。为了避免产生不合理的ADEV值,利用插值技术对对数频率空间重新生成FFT采样数据。因此,数值积分和幂律过程的结果可以很好地吻合。此外,谱密度中的杂散对ADEV结果也有不可忽视的影响。例如,在处理本实验室相位噪声测量系统的数据时,有杂散的谱密度产生的ADEV可以达到去除杂散时的三倍
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引用次数: 0
2nd Harmonic Power Enhancement of FET DRO with Additional Dielectric Resonator 附加介质谐振腔对FET DRO的二次谐波功率增强
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275505
J. Kwon, I. Kim
This paper reports that the output signal power of a series feedback FET DRO (dielectric resonator oscillator), at the second harmonic frequency, can be significantly enhanced with an additional DR (dielectric resonator) at the drain port. This enhancement has been observed by an experiment and analyzed based on reflection and feedback mechanism between two DRs. Finally we propose that there is an optimum reflection condition and location of the second DR to extract the maximum output power at the second harmonic frequency from the FET DRO
本文报道了在漏极处增加一个介电谐振器,可以显著增强串联反馈场效应管DRO(介电谐振振荡器)的二次谐波输出信号功率。通过实验观察了这种增强,并基于两个dr之间的反射和反馈机制对其进行了分析。最后,我们提出了一个最佳反射条件和二次DR的位置,以从FET的DRO中提取二次谐波频率下的最大输出功率
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引用次数: 0
Relativity and Timing in X-ray Pulsar Navigation x射线脉冲星导航中的相对论和定时
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275485
N. Ashby, D. Howe
XNAV is a technology demonstration involving many organizations that will use photons from X-ray pulsars for navigation and spacecraft attitude determination. This paper summarizes relativistic effects in the context of XNAV. It also characterizes the primary task in the time domain of realizing an on-board master clock that time-tags detected X-ray photons with sufficient accuracy to permit meaningful navigation solutions. XNAV must first estimate the periods of uncatalogued X-ray pulsars to determine suitable candidate pulsars for navigation. This task will use an efficient search algorithm to determine the pulsar period from a sensor aimed at the pulsar. As a part of this search and catalogue task, an accumulator that integrates photon counts will compute average counts per sampling time interval, in time bins that are small compared to the pulsar's period. This operation is dubbed the pulsar profiler function. It is intended to build a reference or standard profile of a chosen pulsar for later use. The search and catalogue need to be sufficient for navigation based on times-of-arrival of pulsar signals in real time vs. the on-board reference clock. Operationally, the timing module locates in time the highest peak (or other defined phase center) in the group velocity of received, periodic plane-wave pulses from catalogued pulsars. The goal is to permit navigation accuracy approaching 100 m. This will be accomplished by cross-correlation of catalogued profiles to incoming profiles based on X-ray sensor data collected in real time
XNAV是一项涉及许多组织的技术演示,将使用来自x射线脉冲星的光子进行导航和航天器姿态确定。本文综述了XNAV背景下的相对论效应。它还描述了在时域内实现车载主时钟的主要任务,该时钟的时间标签以足够的精度检测x射线光子,从而允许有意义的导航解决方案。XNAV必须首先估计未编目的x射线脉冲星的周期,以确定适合导航的候选脉冲星。这项任务将使用一种有效的搜索算法,从瞄准脉冲星的传感器确定脉冲星周期。作为搜索和编目任务的一部分,集成光子计数的累加器将计算每个采样时间间隔的平均计数,与脉冲星的周期相比,这个时间间隔很小。这个操作被称为脉冲星剖面函数。它的目的是为选定的脉冲星建立一个参考或标准的轮廓以供以后使用。根据脉冲星信号的实时到达时间和机载参考时钟,搜索和目录需要足够的导航。在操作上,定时模块及时定位从编目脉冲星接收到的周期性平面波脉冲群速度的最高峰(或其他定义的相位中心)。目标是使导航精度接近100米。这将通过将编目剖面与基于实时收集的x射线传感器数据的传入剖面相互关联来完成
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引用次数: 9
Calculation of Bi-mesa Structures Suitable for Mounting 适合安装的双台面结构计算
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275379
S. Goka, Y. Mase, H. Sekimoto, Y. Watanabe
We calculated an improved bimesa structure, ones that has two mesa steps and is suitable for mounting using a two-dimensional finite element method in the X-Y' region. The frequency differences between clamp and free X-edge conditions were estimated as an index of mounting influences. When the outer mesa height was lower than 20% of the thick area, the frequency differences were less than 10% of standard-type bimesa resonator values. These results indicate that our bi-mesa structure has good separation from the mounting influences
我们计算了一种改进的双台面结构,它有两个台面台阶,适合在X-Y区域使用二维有限元方法安装。估计夹紧和自由x边条件之间的频率差异作为安装影响的指标。当外台面高度小于厚度的20%时,频率差小于标准型双模谐振器值的10%。这些结果表明,我们的双台面结构对安装影响有很好的隔离作用
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引用次数: 1
88Sr+ Single-Ion Optical Frequency Standard 88Sr+单离子光频率标准
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275420
P. Dubé, A. Madej, J. Bernard, A. Shiner
The electric quadrupole shift is an important source of systematic uncertainty in several single-ion optical frequency standards. In this paper, we review the electric quadrupole shift cancellation method based on the Zeeman spectrum of the clock transition. The method is demonstrated with an actual frequency measurement of the 5s2S 1/2-4d2D5/2 transition of 88Sr+. This cancellation method also removes shifts from the tensor part of the Stark effect. Further analysis of the data provides an evaluation of the micromotion shifts which are then applied to correct the observed ion clock frequency. Recent improvements to our probe laser system and the observation of Fourier-transform limited linewidths of 5 Hz at 445 THz are also reported
电四极移是几种单离子光学频率标准中系统不确定度的重要来源。本文综述了基于时钟跃迁的塞曼谱的电四极移抵消方法。通过对88Sr+的5s2S 1/2-4d2D5/2跃迁的实际频率测量,验证了该方法的有效性。这种抵消方法也消除了斯塔克效应张量部分的偏移。对数据的进一步分析提供了微动位移的评估,然后应用于校正观察到的离子时钟频率。本文还报道了我们的探测激光系统的最新改进,以及在445太赫兹下观察到的5赫兹的傅里叶变换限制线宽
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引用次数: 7
Parallel-Coupled Square-Resonator Micromechanical Filter Arrays 平行耦合方形谐振器微机械滤波器阵列
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275434
J.R. Clark, Minfan Pai, B. Wissman, G. He, W. Hsu
Large, parallel-coupled arrays of micromechanical square resonators have been demonstrated, greatly reducing the equivalent impedance of the aggregate resonator by up to a factor of 30 in an array of 30 strongly-coupled devices while retaining quality factors approaching 10,000. In addition, multiple strong-coupled arrays have been weakly coupled via mechanical linkage in order to form a 10.7MHz IF filter, such as would be required in a heterodyning FM radio system, with greatly reduced matching impedance requirements
大型、平行耦合的微机械方形谐振器阵列已经被证明,在30个强耦合器件阵列中,大大降低了聚合谐振器的等效阻抗,而保持了接近10,000的质量因子。此外,为了形成10.7MHz中频滤波器,多个强耦合阵列通过机械连接进行弱耦合,如外差调频无线电系统中所需要的那样,大大降低了匹配阻抗要求
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引用次数: 12
Development of an Optical Lattice Clock in NMIJ, AIST AIST NMIJ光学点阵时钟的研制
Pub Date : 2006-06-01 DOI: 10.1109/FREQ.2006.275397
M. Yasuda, F. Hong, T. Kurosu, T. Kohno, J. Ishikawa, A. Onae, S. Ohshima, H. Katori
A development plan and the present status of the optical lattice clock in NMIJ, especially the details of the vacuum system and the laser sources, are described
介绍了NMIJ光学晶格钟的发展计划和现状,特别是真空系统和激光源的细节
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引用次数: 1
期刊
2006 IEEE International Frequency Control Symposium and Exposition
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