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Satellite surface charging in LEO with ProPIC 利用 ProPIC 在低地轨道进行卫星表面充电
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-29 DOI: 10.1016/j.actaastro.2024.10.057
Simone Di Fede , Basman Elhadidi , Mirko Magarotto , Wai Lee Chan
ProPIC is a fully kinetic particle-in-cell (PIC) solver developed for space electric propulsion. This work has extended its capabilities to simulate satellite surface charging and wake generation in low Earth orbit (LEO). A novel scaling approach has been implemented, decreasing computational cost by more than one order of magnitude. The methodology and scaling approach have been verified against the revised orbital-motion-limited theory. The surface charging and wake generation in LEO have been examined for a satellite that is more complex and larger than what is typically handled with a fully kinetic PIC approach in LEO, particularly due to the presence of large solar panels. Notably, the simulated wake can be used to identify the optimal position for the plasma diagnostic sensor that minimizes interference with the wake. Moreover, despite not being a failure risk, the attitude greatly influences the surface charging of a satellite with large solar arrays installed parallel to the satellite speed vector. The study suggests that, for high positive pitch angles (>45), the surface charging of the solar panels can increase by as much as 75% compared to low negative pitching cases. Additionally, the study highlights that the pitch angle and satellite envelope along the motion direction significantly influence the potential gradients on the solar panels.
ProPIC 是为空间电力推进开发的全动能粒子入胞(PIC)求解器。这项工作将其功能扩展到模拟低地球轨道(LEO)上的卫星表面充电和尾流生成。采用了一种新颖的缩放方法,将计算成本降低了一个数量级以上。该方法和缩放方法已根据修订后的轨道运动限制理论进行了验证。对低地轨道上的表面充电和尾流生成进行了研究,该卫星比通常在低地轨道上采用全动能 PIC 方法处理的卫星更复杂、更大,特别是由于存在大型太阳能电池板。值得注意的是,模拟尾流可用于确定等离子诊断传感器的最佳位置,从而最大限度地减少对尾流的干扰。此外,尽管不存在故障风险,但姿态会极大地影响安装了与卫星速度矢量平行的大型太阳能电池阵列的卫星的表面充电。研究表明,在高正俯仰角(45∘)情况下,太阳能电池板的表面充电比低负俯仰角情况下增加 75%。此外,研究还强调,俯仰角和卫星沿运动方向的包络线对太阳能电池板上的电势梯度有显著影响。
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引用次数: 0
Martian buildings: Feasible cement/concrete for onsite sustainable construction from the structural point of view 火星建筑:从结构角度看现场可持续建筑的水泥/混凝土可行性
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-29 DOI: 10.1016/j.actaastro.2024.10.056
Omid Karimzade Soureshjani, Ali Massumi, Gholamreza Nouri
Colonizing other planets, like Mars, marks a significant milestone in the pursuit of a multi-planetary existence. Millions of people would settle on Mars in self-sufficient bases. Colonizing Mars is a long-term mission that demands self-sufficient, secure habitats and comprehensive planning. Importing structures, such as inflatable structures, from Earth is cost-prohibitive, making the utilization of in-situ resources and onsite construction the most viable approach for preparing the required buildings. Studies have shown that it is possible to produce and craft several kinds of binders and concretes with appropriate mechanical behavior using Martian soil composition; however, determining the optimal option for onsite construction remains a challenge. This study investigates available cement/concrete options for onsite construction on Mars from a structural engineering perspective, taking into account the available resources and technologies. In this regard, the observations and data provided by Martian landers, rovers, orbiters and methods such as Viking-1 & 2, Pathfinder, Spirit, Opportunity, Curiosity, Mars Express, Ultraviolet–visible/Near-infrared reflectivity spectra and Alpha particle X-ray spectrometer were used to obtain a comprehensive and detailed investigation. Eleven types of Martian cement/concrete based on the in-situ resources, soil composition, and available technologies were compared based on the criteria and indices defined in accordance with the structural engineering point of view to select the best practical option for onsite construction. These criteria encompass factors such as mechanical behavior, Martian structural loads, raw material accessibility, available sources, energy required for production, water requirement, curing and hardening time, possibility of using 3D printers, byproduct usefulness, conditions required for hardening and curing, importation requirements from Earth, production complexity, long-term durability and behavior under galactic cosmic rays (GCRs) and solar energetic particles (SEPs). The pros and cons of each cement/concrete option are thoroughly assessed, considering the harsh conditions on Mars. Additionally, the study highlights extra considerations that are crucial for onsite construction on Mars. To determine the best practical option for onsite construction and sustainable colonization, the proposed cements/concretes were compared using multi-scale spider/radar diagrams and a quantitative point of view. This perspective was enabled by assigning weights to each criterion through expert consultation, experimental data, and literature review, ensuring that the diagrams accurately reflect the features of each concrete mix. This comprehensive investigation aims to provide valuable insights into selecting the most suitable cement/concrete for onsite construction on Mars, considering the structural engineering perspective and the long-term goal of sustainable colonization.
殖民火星等其他星球是人类追求多行星生存的一个重要里程碑。数百万人将在火星上建立自给自足的基地。殖民火星是一项长期任务,需要自给自足、安全的居住地和全面的规划。从地球进口充气式结构等建筑成本高昂,因此利用原地资源和现场施工是准备所需建筑的最可行方法。研究表明,利用火星土壤成分可以生产和制作多种具有适当机械性能的粘结剂和混凝土;然而,确定现场施工的最佳方案仍然是一项挑战。本研究从结构工程的角度出发,考虑到现有的资源和技术,对火星现场施工可用的水泥/混凝土方案进行了研究。在这方面,利用火星登陆器、漫游车、轨道器和方法(如维京 1 号和amp; 2 号、探路者、精神号、机遇号、好奇号、火星快车、紫外线-可见光/近红外反射光谱仪和阿尔法粒子 X 射线光谱仪)提供的观测结果和数据进行了全面详细的调查。根据结构工程学观点确定的标准和指数,对基于原地资源、土壤成分和现有技术的 11 种火星水泥/混凝土进行了比较,以选择现场施工的最佳实用方案。这些标准包括机械性能、火星结构荷载、原材料的可获得性、可用资源、生产所需的能源、水需求、固化和硬化时间、使用 3D 打印机的可能性、副产品的实用性、硬化和固化所需的条件、从地球进口的要求、生产的复杂性、长期耐久性以及在银河宇宙射线(GCR)和太阳高能粒子(SEP)下的性能等因素。考虑到火星上的恶劣条件,对每种水泥/混凝土方案的利弊进行了全面评估。此外,研究还强调了对火星现场施工至关重要的额外考虑因素。为了确定现场施工和可持续殖民化的最佳实用方案,使用多尺度蜘蛛/雷达图和定量观点对建议的水泥/混凝土进行了比较。通过专家咨询、实验数据和文献综述为每项标准分配权重,确保图表准确反映每种混凝土混合物的特点。这项综合调查旨在从结构工程角度和可持续殖民的长期目标出发,为选择最适合火星现场施工的水泥/混凝土提供有价值的见解。
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引用次数: 0
Exploring potential candidates of alternative solid hydrocarbon propellants for cold-gas thrusters 探索冷气体推进器替代固体碳氢化合物推进剂的潜在候选者
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-28 DOI: 10.1016/j.actaastro.2024.10.047
Thimthana Lee, Mahdi Davoodianidalik, Dimitrios Tsifakis, Roderick W. Boswell, Christine Charles
Cold-gas thrusters play a vital role as a subsystem in satellite operations facilitating space maneuvers in numerous missions. Achieving optimal propulsion necessitates not only continuous development of thruster design but also an exploration of novel propellant options to enhance overall performance. While an ideal propellant remains elusive, many studies have identified alternative options to replace commonly used inert gases. Choosing a solid-state propellant offers benefits such as the absence of a pressurised tank and sloshing effect. Hydrocarbon propellants are advantageous due to their non-corrosiveness and abundance as organic compounds on Earth. The sublimation process for manipulating solid propellants typically requires only a few watts, making it suitable for low-power budget missions. This work presents five solid hydrocarbon propellants for cold-gas thrusters, three of which have not yet been experimentally explored. The comparison between various aspects, including mass flow rate, power consumption, and several key performance parameters, is discussed. The measured mass flow rate is a function of the species and temperature, following the trend of the vapour pressure. The power consumption for all propellants only depends on the required heating temperature as they share similar thermal properties. The thrust generated by each propellant is comparable and linearly proportional to the mass flow rate when the flow is choked. Specific impulse remains relatively constant across different mass flow rates due to the strong correlation between thrust and mass flow rate. The thrust-to-power ratio is generally comparable among the propellants, except hexamine, which demands more power at higher operating temperatures due to increased heat loss. Among these alternatives, camphor emerges as the most promising candidate due to its low power consumption, thrust generation, and mass efficiency. On the other hand, naphthalene offers the best in terms of its superior thrust-to-power ratio and cost-per-kilogram advantage.
冷气体推进器作为卫星运行中的一个子系统,在众多任务中为空间机动提供了便利,发挥着至关重要的作用。要实现最佳推进效果,不仅需要不断开发推进器设计,还需要探索新的推进剂选择,以提高整体性能。虽然理想的推进剂仍然遥不可及,但许多研究已经确定了替代常用惰性气体的备选方案。选择固态推进剂有很多好处,例如不需要加压罐和荡动效应。碳氢化合物推进剂因其不腐蚀性和在地球上大量存在的有机化合物而具有优势。操纵固体推进剂的升华过程通常只需要几瓦的功率,因此适用于低功率预算任务。本研究介绍了五种用于冷气体推进器的固体碳氢化合物推进剂,其中三种尚未进行过实验探索。讨论了各方面的比较,包括质量流量、功耗和几个关键性能参数。测得的质量流量是种类和温度的函数,与蒸汽压力的趋势一致。所有推进剂的功耗只取决于所需的加热温度,因为它们具有相似的热特性。每种推进剂产生的推力都相当,并且在阻塞流量时与质量流量成线性比例。由于推力与质量流量之间存在很强的相关性,因此在不同的质量流量下,比冲保持相对恒定。除六胺外,其他推进剂的推力功率比基本相当,六胺在较高的工作温度下由于热损失增加而需要更多的功率。在这些替代品中,樟脑因其低功耗、低推力和质量效率而成为最有前途的候选者。另一方面,萘在推力-功率比和每公斤成本优势方面表现最佳。
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引用次数: 0
Methodology for robust analysis of bolts slippage in cryogenic space missions 低温空间飞行任务中螺栓滑移的稳健分析方法
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-28 DOI: 10.1016/j.actaastro.2024.10.048
Alejandro Fernández-Soler , Andrés García-Pérez , Gianluca Morgante , Javier Pérez-Álvarez , Gustavo Alonso , Laura García-Moreno , Antonio Scippa , Daniele Gottini , Ciro Del Vecchio
The assessment of slippage in cryogenic space missions is fundamental from a mechanical point of view as it is one of the main failure modes of a bolt in a mechanical interface. It is usually performed on the basis of temperature maps obtained from the worst-case thermal design cases, with particular interest in the transient case during the cooldown. Traditionally, the thermal mapping has to be transferred to the detailed FEM model. This process requires a lot of interaction between the thermal and structural disciplines, which is often not easy. Moreover, the thermal mapping usually corresponds to the instant of maximum gradient between the clamped parts along the transient case. In this paper, a new methodology is proposed to speed up the evaluation of the temperature effect on the slippage from an analytical model correlated with the FEM model. Then, the interactions between the structural and the thermal responsible may be reduced. In addition, the proposed methodology evaluates the entire temperature curve of the transient case, rather than a single instant. In this way, the thermal effect on slippage can be evaluated in a robust and agile process, facilitating the definition of requirements in terms of the maximum allowable temperature gradient as a function of preload or vice versa. This methodology has been validated with the primary mirror of the ARIEL mission, which is a cryogenic European mission that aims to study exoplanets by making observations from a thermally stable orbit at L2 point of the Sun-Earth system. Therefore, the correct design of the primary mirror is essential for the successful science observations of the mission.
从机械角度来看,低温空间飞行任务中的滑动评估是非常重要的,因为它是机械接口中螺栓的主要失效模式之一。通常是根据最坏情况下的热设计案例获得的温度图进行评估,尤其关注冷却过程中的瞬态情况。传统上,热映射必须转移到详细的有限元模型中。这一过程需要热学和结构学科之间的大量互动,通常并不容易。此外,热映射通常与瞬态情况下夹紧部件之间的最大梯度瞬间相对应。本文提出了一种新方法,通过与有限元模型相关的分析模型,加快评估温度对滑移的影响。这样就可以减少结构和热影响之间的相互作用。此外,所提出的方法还能评估瞬态情况下的整个温度曲线,而不是单个瞬间。这样,就能以稳健、灵活的方式评估热效应对滑移的影响,从而便于根据最大允许温度梯度作为预紧力的函数或反之亦然来定义要求。这一方法已通过 ARIEL 任务的主反射镜进行了验证,ARIEL 是欧洲的一项低温任务,旨在通过从太阳-地球系统 L2 点的热稳定轨道上进行观测来研究系外行星。因此,主镜的正确设计对于该飞行任务成功进行科学观测至关重要。
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引用次数: 0
Combination of altimetry crossovers and Doppler observables for orbit determination and geodetic parameter recovery: Application to Callisto 结合测高交叉和多普勒观测数据进行轨道测定和大地参数恢复:对卡利斯托的应用
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-28 DOI: 10.1016/j.actaastro.2024.10.045
William Desprats , Stefano Bertone , Daniel Arnold , Martin Lasser , Adrian Jäggi , Michel Blanc
An accurate knowledge of the orientation, the tidal deformability, and the gravity field of a celestial body is fundamental to provide constraints on its internal structure. These quantities may be retrieved by processing radiometric tracking and altimetry data from a probe in orbit around such body. This paper presents a method to combine altimetry crossovers with two-way Doppler tracking observations at normal equation level, using the Bernese GNSS Software and the pyXover software library. This method was applied to a proposed 200 km altitude orbiter around Callisto, a privileged destination for the upcoming phase of Solar System exploration. Enhancing “standard” Doppler tracking with altimetry generally benefited both orbit determination and a joint estimation of the orientation of the north pole and of planetary librations. The retrieval of low-degree gravity field parameters was also improved by the addition of altimetry data. However, the improvements on the estimated parameters were highly dependent on the characteristics of the simulation, e.g., the underlying topography roughness. Overall, combining radioscience with altimetry data accounted for a visible reduction of correlations among estimated parameters, while also allowing for a consistent estimation of the “vertical” Love number h2 along with gravity.
准确了解一个天体的方位、潮汐变形能力和重力场是对其内部结构提供约束的基础。这些数据可通过处理围绕该天体运行的探测器的辐射跟踪和测高数据来获取。本文介绍了一种方法,利用伯尔尼全球导航卫星系统软件和 pyXover 软件库,将测高交叉与正常等式水平的双向多普勒跟踪观测结合起来。该方法被应用于围绕卡利斯托的拟议 200 公里高度轨道飞行器,卡利斯托是即将到来的太阳系探索阶段的重要目的地。用测高法加强 "标准 "多普勒跟踪,总体上有利于轨道确定以及对北极和行星天平的方位进行联合估计。由于增加了测高数据,低度重力场参数的检索也得到了改进。不过,对估计参数的改进在很大程度上取决于模拟的特征,例如底层地形的粗糙度。总之,将无线电科学与测高数据结合起来,可以明显降低估计参数之间的相关性,同时还可以对 "垂直 "洛夫数 h2 和重力进行一致的估计。
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引用次数: 0
A review of international best practices in integrating space launch activities with air traffic management: Guidance for future space launch in the Singapore region 审查将航天发射活动与空中交通管理相结合的国际最佳做法:新加坡地区未来航天发射指南
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-28 DOI: 10.1016/j.actaastro.2024.10.010
Imen Dhief , Zhengyi Wang , Wei Zhou , Sameer Alam , Anouk Stahnke , Lorenz Losensky , Tobias Rabus , Sven Kaltenhäuser
<div><div>The integration of space-based assets into our daily lives has seen a remarkable surge, with numerous industries and sectors heavily relying on satellite communications, remote sensing, and global navigation satellite system (GNSS) technology. As space emerges as an indispensable commercial domain, several countries and private companies have actively engaged in space activities.</div><div>Space launch operations involve a collaborative effort among diverse stakeholders, including space agencies, space companies, the military, and aviation sectors. While space launch processes share similarities globally, each country faces unique challenges and adopts distinct mechanisms due to its specificities. Thus, initiating space launch activities requires a thorough examination of a country’s unique features. This includes assessing their impact on existing air traffic, considering safety concerns, implementing temporary restrictions, promoting communication, and mitigating operational disruptions. This is crucial as space launch trajectories intersect with established flight paths, influencing aviation operations.</div><div>The proposed review aims to explore the details of space launch procedures and policies by various countries, namely the United States, France, the United Kingdom, Japan, South Korea, and New Zealand. The objective is to lay a foundation for establishing future procedures and policies to integrate space launch activities with air traffic, particularly for countries that are new to this field. This is performed by examining international best practices in space launch operations, considering the unique challenges faced by countries, such as geographical location, collaboration with neighbors, and their familiarity with such operations. The examination exposes the diverse approaches and considerations involved in different stages of the space launch activity process, including the pre-mission, execution, and post-mission phases, with an emphasis on the best practices adopted to integrate space launch activities within air traffic. Furthermore, the current review paper aims to evaluate the suitability of potential future space launches initiated from the Singapore Flight Information Region (FIR). Singapore’s equatorial positioning makes it particularly favorable for such initiatives. Nevertheless, the initiation of space launch activities from the Singapore FIR raises significant concerns regarding its potential impact on the substantial volume of air traffic traversing the airspace in regions encompassing Singapore, Malaysia, and Indonesia. Moreover, considering Singapore’s recognition as a maritime hub, there are potential implications for maritime traffic. Consequently, this study discusses the potential implications of a future space launch conducted from Singapore FIR on the broader regional landscape.</div><div>The paper also presents guidance to effectively plan and prepare for future space-launch requirements in the Sin
天基资产融入我们的日常生活的速度显著加快,许多行业和部门都严重依赖卫星通信、遥感和全球导航卫星系统(GNSS)技术。随着太空逐渐成为一个不可或缺的商业领域,一些国家和私营公司也积极参与太空活动。虽然太空发射过程在全球范围内具有相似性,但每个国家都面临着独特的挑战,并因其具体国情而采用不同的机制。因此,启动太空发射活动需要对一个国家的独特性进行彻底研究。这包括评估其对现有空中交通的影响、考虑安全问题、实施临时限制、促进沟通以及减少运行中断。这一点至关重要,因为空间发射轨迹与既定飞行路线相交,影响航空业务。拟议的审查旨在探讨各国空间发射程序和政策的细节,即美国、法国、英国、日本、韩国和新西兰。目的是为制定未来的程序和政策奠定基础,以便将空间发射活动与空中交通结合起来,特别是对于新进入这一领域的国家。为此,考虑到各国面临的独特挑战,如地理位置、与邻国的合作以及对此类操作的熟悉程度,研究了空间发射操作方面的国际最佳做法。审查揭示了空间发射活动过程不同阶段所涉及的各种方法和考虑因素,包括任务前、执行和任务后阶段,重点是将空间发射活动纳入空中交通所采用的最佳做法。此外,本审查文件旨在评估未来可能从新加坡飞行情报区(FIR)启动的航天发射的适宜性。新加坡的赤道定位使其特别适合开展此类活动。然而,从新加坡飞行情报区启动航天发射活动会对穿越新加坡、马来西亚和印度尼西亚等地区空域的大量空中交通造成潜在影响,这引起了人们的极大关注。此外,考虑到新加坡是公认的海上枢纽,海上交通也可能受到影响。因此,本研究讨论了未来从新加坡飞行情报区进行太空发射对更广泛的区域景观的潜在影响。本文件还为有效规划和准备新加坡区域未来的太空发射需求提供了指导。研究强调了新加坡计划在未来开展航天发射行动时必须考虑的三条关键经验。首先,新加坡应设立独立和协作的行政单位,负责监督安全、运营、许可、政策、国际关系和航天港。其次,必须优先考虑国家和国际安全因素。这可以通过实施强有力的风险管理框架和促进利益攸关方之间高效的区域和跨境合作来实现。最后,在操作层面,有必要在空间发射提供商、空中交通管制和当局之间建立有效的协作规划流程和沟通渠道,以确保实时安全和操作效率。此外,本研究还建议新加坡地区采用混合空域一体化运行概念(CONOPS),确保未来太空发射活动在新加坡空域内安全高效地进行,同时与常规空中交通共存。通过研究领先国家的最佳实践,新加坡可以建立一个以安全、协作和创新为优先的强大的太空生态系统。值得注意的是,新加坡飞行情报区就太空发射活动提供的指导和建议仅供参考,因为本地区目前还没有此类活动的近期计划。
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引用次数: 0
Attitude tracking of rigid-liquid-flexible coupling spacecraft by active disturbance rejection control 通过主动干扰抑制控制实现刚液柔耦合航天器的姿态跟踪
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-24 DOI: 10.1016/j.actaastro.2024.10.053
Xiaowei Zhang , Shuang Li , He Zhu , Jingji Wang
Considering the complex attitude dynamics of Rigid-Liquid-Flexible Coupling Spacecraft, especially when the large amplitude sloshing of liquid exists in rapid attitude maneuver, the conventional control design method based on the linearized model is not suitable for the significant coupling and strong nonlinearity. By contrast, Active Disturbance Rejection Control is model-independent and easy to design and implement. In this paper, the three main components of Active Disturbance Rejection Control, Tracking Differentiator, Extended State Observer and Nonlinear State Error Feedback are comprehensively applied to the attitude tracking control of Rigid-Liquid-Flexible Coupling Spacecraft. Firstly, two cascaded Tracking Differentiators are used to arrange the transition process of the attitude command, which not only reduces overshoot and oscillation of the tracking process, but also obtains the angular acceleration information of attitude trajectory for feed-forward compensation. Secondly, the total disturbance caused by liquid sloshing and flexible vibration is observed by Extended State Observer and compensated synchronously. Finally, the Nonlinear State Error Feedback is used to further improve the transient behavior and steady-state quality of the control system. The simulation results show that the tracking accuracy of the attitude and angular velocity using the Active Disturbance Rejection Control are about 3–27 times and 6 to 115 times that of the PID control, respectively. The convergence time, overshooting are also significantly less than the PID control.
考虑到刚性-液体-柔性耦合航天器复杂的姿态动力学特性,尤其是在快速姿态机动中存在大振幅液体荡动的情况下,基于线性化模型的传统控制设计方法并不适用于耦合度大、非线性强的情况。相比之下,主动干扰抑制控制与模型无关,易于设计和实施。本文将主动干扰抑制控制的三个主要组成部分--跟踪微分器、扩展状态观测器和非线性状态误差反馈综合应用于刚液柔耦合航天器的姿态跟踪控制。首先,利用两个级联跟踪微分器来安排姿态指令的过渡过程,不仅减少了跟踪过程的过冲和振荡,还获得了姿态轨迹的角加速度信息,用于前馈补偿。其次,通过扩展状态观测器观测液体滑动和柔性振动引起的总扰动,并进行同步补偿。最后,利用非线性状态误差反馈进一步改善控制系统的瞬态行为和稳态质量。仿真结果表明,采用主动干扰抑制控制的姿态和角速度跟踪精度分别是 PID 控制的 3-27 倍和 6 至 115 倍。收敛时间和过冲也明显小于 PID 控制。
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引用次数: 0
Mesenchymal stem cell transplant as an intervention to ameliorate disuse-induced muscle atrophy in a mouse model of simulated microgravity 间充质干细胞移植作为一种干预措施,可改善小鼠模拟微重力模型中由废用引起的肌肉萎缩
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-24 DOI: 10.1016/j.actaastro.2024.10.060
Rizwan Qaisar , Megna Srinivas , Muhammad Tehsil Gul , Amir Ali Khan , Anu Ranade , Josemin Jose , Gopika Ramachandran , Suni Ebby , Firdos Ahmad , Asima Karim

Background

The hindlimb unloaded (HU) mouse model exhibits disuse-induced muscle atrophy. However, effective interventions remain elusive. We investigated the therapeutic potential of mesenchymal stem cells (MSC) transplant on muscle decline in HU mice.

Methods

We divided 4-month-old male c57BL/6j mice into controls and HU mice treated with PBS as placebo (HU-PBS) or MSCs (HU-MSC; one million cells/100 μl PBS into gastrocnemius muscles once a week) for three weeks. We measured muscle mass, grip strength, and an unbiased transcriptome analysis of gastrocnemius muscles.

Results

MSC treatment prevented muscle atrophy and improved grip strength in HU mice. Transcriptome analysis revealed MSC-induced unique (557 genes) and differential (1214 genes) expressions of several genes compared to the HU-PBS group. GO and KEGG term analysis revealed an HU-induced downregulation of pathways associated with the regulation of contractile apparatus, neuromuscular junction, and satellite cell function, which were partly reversed with MSC treatment. Lastly, MSC treatment also upregulated the pathways controlling muscle differentiation and growth in the HU mice.

Conclusion

Altogether, we report the therapeutic potential of MSCs in treating disuse-induced muscle atrophy and weakness. Our study may help unravel novel molecular mechanisms involved in MSCs-induced muscle restoration.
背景后肢无负荷(HU)小鼠模型表现出失用引起的肌肉萎缩。然而,有效的干预措施仍然难以捉摸。我们将4个月大的雄性c57BL/6j小鼠分为对照组和用PBS作为安慰剂(HU-PBS)或间充质干细胞(HU-MSC;100万个细胞/100微升PBS注入腓肠肌,每周一次)治疗的HU小鼠,为期三周。我们测量了肌肉质量、握力,并对腓肠肌进行了无偏见的转录组分析。转录组分析显示,与HU-PBS组相比,间充质干细胞诱导了多个基因的独特表达(557个基因)和差异表达(1214个基因)。GO和KEGG术语分析显示,HU诱导的与调节收缩器、神经肌肉接头和卫星细胞功能相关的通路下调,而间叶干细胞治疗可部分逆转这些下调。最后,间充质干细胞治疗还上调了控制HU小鼠肌肉分化和生长的通路。我们的研究可能有助于揭示间充质干细胞诱导肌肉恢复的新分子机制。
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引用次数: 0
Penetration based lunar regolith thermal conductivity inversion: Method and verification 基于穿透的月球沉积物热导率反演:方法与验证
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-24 DOI: 10.1016/j.actaastro.2024.10.030
Jiachen Zhu , Junyue Tang , Cheng Chi , Junxiao Xiao , Shengyuan Jiang , Weiwei Zhang , Zixiao Lu , Ziming Chen
Based on the temperature change data of the penetrator, to achieve in-situ detection of the thermal conductivity of the lunar regolith profile, it is necessary to establish a heat conduction model between the penetrator and the lunar regolith. This study simplifies the heat conduction model of the complex shaped penetrator through simulation analysis results. Then, we proposed a thermal conductivity inversion method based on the transient thermal cylinder source model. The thermal diffusion test was carried out under normal temperature and pressure on a standard reference object with known thermal conductivity and the thermal conductivity inversion work was completed, which verified the feasibility of the inversion method. Then, we completed the thermal diffusion test of the penetrator and the lunar regolith simulant under the simulated low-temperature vacuum environment of the lunar surface, and carried out the thermal conductivity inversion of the lunar regolith simulant based on the thermal diffusion test data, which proved that the proposed thermal inversion method is applicable for the lunar regolith under the low-temperature vacuum. Finally, the thermal conductivity test was conducted on icy lunar regolith simulant with different water contents and a thermal diffusion test in a vacuum low-temperature environment was carried out. The thermal conductivity inversion was completed using the same method, which proved that the inversion method is suitable for icy lunar regolith simulant.
根据穿透器的温度变化数据,要实现对月球岩石剖面导热性能的原位探测,就必须建立穿透器与月球岩石之间的热传导模型。本研究通过模拟分析结果简化了复杂形状穿透器的热传导模型。然后,我们提出了一种基于瞬态热圆柱源模型的导热反演方法。在已知导热系数的标准参考物体上进行了常温常压下的热扩散试验,并完成了导热系数反演工作,验证了反演方法的可行性。然后,我们在模拟的月面低温真空环境下完成了穿透器和月球岩石模拟物的热扩散试验,并根据热扩散试验数据对月球岩石模拟物进行了热导率反演,证明所提出的热反演方法适用于低温真空环境下的月球岩石。最后,对不同含水量的冰质月球岩石模拟物进行了导热试验,并进行了真空低温环境下的热扩散试验。用同样的方法完成了热导率反演,证明反演方法适用于冰质月球岩石模拟物。
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引用次数: 0
DIANA: An underwater analog space mission DIANA:水下模拟太空任务
IF 3.1 2区 物理与天体物理 Q1 ENGINEERING, AEROSPACE Pub Date : 2024-10-24 DOI: 10.1016/j.actaastro.2024.10.044
Marek Sokol , Petr Volf , Jan Hejda , Lydie Leová , Jan Hýbl , Michal Schmirler , Jakub Suchý , Roman Procházka , Miroslav Charvát , Klára Seitlová , Martin Dolejš , Jiří Schneider , Patrik Kutílek
The DIANA mission represents an underwater analog space mission designed to simulate and study the impact of long-duration spaceflight and extraterrestrial habitation on crew performance, psychosocial dynamics, and technological systems. The mission utilized an underwater habitat, the Hydronaut H03 DeepLab, to mimic the isolated, confined, and extreme (ICE) environment of space. Over eight days, a six-member crew lived and worked in underwater (3) and water surface (3) habitats, performing scientific experiments and operational tasks. The mission schedule encompassed a variety of activities such as drone exploration, extravehicular activities (EVAs), soil sampling, and media interactions, culminating in a simulated departure from the lunar surface. Data collection methods included continuous biomedical monitoring, cognitive task assessments, and sociomapping to analyze team communication and cooperation. This paper provides an overview of the mission architecture and outcomes, offering valuable insights into the challenges of future human space exploration and informing improvements in crew selection, training, and support systems.
DIANA 任务是一项水下模拟空间任务,旨在模拟和研究长期太空飞行和地外居住对乘员表现、社会心理动态和技术系统的影响。这次任务利用一个水下栖息地--Hydronaut H03 DeepLab--来模拟孤立、封闭和极端(ICE)的太空环境。在八天时间里,六名机组人员在水下(3 个)和水面(3 个)栖息地生活和工作,执行科学实验和操作任务。任务安排包括各种活动,如无人机探索、舱外活动(EVA)、土壤取样和媒体互动,最后是模拟离开月球表面。数据收集方法包括持续的生物医学监测、认知任务评估以及分析团队交流与合作的社会绘图。本文概述了这次任务的结构和成果,对未来人类太空探索的挑战提供了宝贵的见解,并为改进乘员选拔、培训和支持系统提供了信息。
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引用次数: 0
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Acta Astronautica
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