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Recalling and anticipating positive events to improve the positive affect and mental health of adolescents: A cluster randomized controlled trial in secondary schools 回忆和预测积极事件以改善青少年的积极情感和心理健康:中学分组随机对照试验
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-16 DOI: 10.1016/j.brat.2024.104543
L. Bogaert , D. Hallford , E. Loyen , A. D'Argembeau , F. Raes

This cluster randomized controlled trial examined the effectiveness of Positive Events Training (PET), a combined group training aimed at simultaneously improving positive autobiographical memory (AM) and episodic future thinking (EFT) among adolescents (12–16 years). Delivered as a universal school-based program, PET was compared with an active (creative writing) control group (CREAT). Effects on resilience, wellbeing, positive emotions, emotional response styles towards positive emotions (savoring, dampening), anhedonia, depressive symptoms, and multiple AM and EFT indices were examined. Adolescents (N PET = 95, N CREAT = 93) completed self-report scales at baseline, post-training and two-month follow-up. Multilevel models revealed that PET led to significant improvements in certain AM and EFT skills. Moreover, a decrease in anhedonia was observed at post-training. However, this effect did not withstand correction for multiple testing. Absence of changes in the other outcomes should be interpreted within the context of the universal school-based approach and the potential limited scope for detectable changes. Exploratory analyses suggest the importance of further investigating PET's potential in addressing positive affect dysregulations in indicated samples, and exploring perceived likelihood of generated future events and dampening as potential underlying mechanisms. Study limitations and future directions to maximize the demonstrated potential of PET are discussed.

这项分组随机对照试验考察了 "积极事件训练"(PET)的有效性,该训练是一项综合小组训练,旨在同时改善青少年(12-16 岁)的积极自传体记忆(AM)和外显未来思维(EFT)。作为一项以学校为基础的普及计划,PET 与积极(创意写作)对照组(CREAT)进行了比较。研究了该课程对复原力、幸福感、积极情绪、对积极情绪的情绪反应方式(回味、抑制)、失乐症、抑郁症状以及多种 AM 和 EFT 指数的影响。青少年(PET = 95 人,CREAT = 93 人)在基线、培训后和两个月的随访中完成了自我报告量表。多层次模型显示,PET 显著提高了某些 AM 和 EFT 技能。此外,在培训后还观察到失乐症有所减轻。但是,这种效果经不起多重测试校正。其他结果没有变化,应结合普遍的校本方法和可检测变化的潜在有限范围来解释。探索性分析表明,必须进一步研究 PET 在解决指定样本中积极情绪失调方面的潜力,并探索产生未来事件的感知可能性和作为潜在内在机制的抑制作用。本文还讨论了研究的局限性和未来方向,以最大限度地发挥 PET 已证明的潜力。
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引用次数: 0
Is informal practice associated with outcomes in loving-kindness and compassion training? Evidence from pre-post and daily diary assessments 非正式练习与仁爱和同情训练的结果有关吗?事后和每日日记评估的证据
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-08 DOI: 10.1016/j.brat.2024.104537
Qiang Xie , Kevin M. Riordan , Scott A. Baldwin , Otto Simonsson , Matthew J. Hirshberg , Cortland J. Dahl , Inbal Nahum-Shani , Richard J. Davidson , Simon B. Goldberg

We investigated whether informal meditation practice (i.e., self-reported application of meditative techniques outside a period of formal meditation) was associated with outcomes in smartphone-based loving-kindness and compassion training. Meditation-naïve participants (n = 351) with clinically elevated symptoms completed measures of psychological distress, loneliness, empathy, and prosociality at baseline and following a two-week intervention. Informal practice, psychological distress, and loneliness were also assessed daily. Steeper increases in informal practice had small associations with pre-post improvements in distress (r = −.18, p = .008) and loneliness (r = −.19, p = .009) but not empathy or prosociality. Using a currently recommended approach for establishing cross-lagged effects in longitudinal data (latent curve model with structured residuals), higher current-day informal practice was associated with decreased next-day distress with a very small effect size (βs = −.06 to −.04, p = .018) but not decreased next-day loneliness. No cross-lagged associations emerged from distress or loneliness to informal practice. Findings suggest that further investigation into a potential causal role of informal practice is warranted. Future studies experimentally manipulating informal practice are needed.

我们研究了非正式冥想练习(即在正式冥想之外自我报告的冥想技巧应用)是否与基于智能手机的爱心和同情心训练的结果有关。未参加过冥想的临床症状升高者(351 人)在基线和两周干预后完成了心理压力、孤独感、同情心和亲社会性的测量。每天还对非正式练习、心理困扰和孤独感进行评估。非正式实践的逐步增加与干预前的心理困扰(r = -.18,p = .008)和孤独感(r = -.19,p = .009)改善有微小关联,但与移情或亲社会性无关。使用目前推荐的纵向数据交叉滞后效应(具有结构化残差的潜在曲线模型),当日较高的非正式实践与次日较低的苦恼相关,但影响很小(βs = -.06 至 -.04, p = .018),而与次日较低的孤独感无关。苦恼或孤独感与非正式实践之间没有交叉滞后关系。研究结果表明,有必要进一步研究非正式实践的潜在因果作用。未来的研究需要通过实验来操纵非正式实践。
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引用次数: 0
Shorter communications: Exploring the impact of a brief smartphone-based alcohol intervention app (DrinksRation) on the quality of life of UK military veterans 简短交流:探索基于智能手机的简短酒精干预应用程序(DrinksRation)对英国退伍军人生活质量的影响
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-06 DOI: 10.1016/j.brat.2024.104540
Nora Trompeter , Charlotte Williamson , Roberto J. Rona , Ewan Carr , Amos Simms , Joan Agwuna , Nicola T. Fear , Laura Goodwin , Dominic Murphy , James Shearer , Daniel Leightley

Alcohol misuse – defined as consuming more than 14 units of alcohol per week - is a well-established problem among veterans. This study investigated the change in quality of life among help-seeking UK veterans who completed a 28-day brief alcohol intervention delivered via a digital smartphone application (called DrinksRation) and have previously sought clinical help for a mental health disorder. This study was a secondary outcome analysis of data collected during a randomised control trial. In total, 123 UK veterans participated in the study and were randomly allocated to either the intervention or control arm. Participants completed self-report questionnaires regarding their alcohol use and quality of life (WHOQOL-BREF) at baseline, day 28 (end of intervention), day 84, and day 168. At the primary endpoint (day 84), we found significantly greater improvements in the intervention arm compared to the control arm for psychological quality of life (Cohen's d = 0.47), and environmental quality of life (d = 0.34). However, we observed no statistically significant differences between the intervention and control arm for social relationships and physical quality of life. Further, for day 168 we found no significant differences. Findings suggest that DrinksRation can increase quality of life among help-seeking veterans who have previously sought help for a mental health disorder, but the increases were modest and restricted to certain domains. Additional treatment may be needed for long-term and sustained improvements in quality of life.

在退伍军人中,酗酒(定义为每周饮酒超过 14 单位)是一个公认的问题。这项研究调查了寻求帮助的英国退伍军人的生活质量变化情况,这些退伍军人通过数字智能手机应用程序(名为 DrinksRation)完成了为期 28 天的简短酒精干预,并曾因精神疾病寻求过临床帮助。这项研究是对随机对照试验期间收集的数据进行的二次结果分析。共有 123 名英国退伍军人参与了这项研究,他们被随机分配到干预组或对照组。参与者在基线、第 28 天(干预结束)、第 84 天和第 168 天填写了有关酒精使用和生活质量的自我报告问卷(WHOQOL-BREF)。在主要终点(第 84 天),我们发现与对照组相比,干预组在心理生活质量(Cohen's d = 0.47)和环境生活质量(d = 0.34)方面有明显改善。但是,我们观察到干预组和对照组在社会关系和身体生活质量方面没有明显的统计学差异。此外,在第 168 天,我们也没有发现明显的差异。研究结果表明,DrinksRation 可以提高曾因精神疾病寻求帮助的退伍军人的生活质量,但提高幅度不大,且仅限于某些领域。要想长期、持续地改善生活质量,可能还需要额外的治疗。
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引用次数: 0
Can neutral episodic memories become emotional? Evidence from facial expressions and subjective feelings 中性的外显记忆会变得情绪化吗?来自面部表情和主观感受的证据
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-03 DOI: 10.1016/j.brat.2024.104528
Sascha B. Duken , Franziska Neumayer , Nadza Dzinalija , Merel Kindt , Vanessa A. van Ast , Renée M. Visser

Maladaptive emotional memories are a transdiagnostic feature of mental health problems. Therefore, understanding whether and how emotional memories can change might help to prevent and treat mental disorders. We tested whether neutral memories of naturalistic events can retroactively acquire positive or negative affect, in a preregistered three-day Modification of Valence in Episodes (MOVIE) paradigm. On Day 1, participants (N = 41) encoded memories of neutral movie scenes, representing lifelike naturalistic experiences. On Day 2, they retrieved each episode before viewing a happy, sad, or neutral scene from the same movie (yielding a within-subjects design with a neutral-negative, neutral-positive, and neutral-neutral condition). On Day 3, participants again retrieved each memory from Day 1. We assessed the affective tone of episodes through facial expressions of positive and negative affect (using facial electromyography, fEMG) and through self-reported feelings. Positive updating of neutral episodes led to increased expressions of positive affect, whereas negative updating led to increased self-reported negative feelings. These results suggest that complex neutral episodic memories can retroactively acquire an affective tone, but the effects were modest and inconsistent across affect readouts. Future research should investigate alternative approaches to updating emotional memories that produce more profound changes in the valence of memories.

适应不良的情绪记忆是心理健康问题的一个跨诊断特征。因此,了解情绪记忆是否会改变以及如何改变可能有助于预防和治疗精神障碍。我们在一个预先登记的为期三天的 "情节中的情感改变(MOVIE)"范式中,测试了自然事件的中性记忆是否会追溯性地获得积极或消极情感。第 1 天,参与者(41 人)对中性的电影场景进行编码记忆,这些场景代表了栩栩如生的自然体验。第 2 天,受试者在观看同一部电影中的快乐、悲伤或中性场景之前检索每个情节(这是一个受试内设计,包括中性-消极、中性-积极和中性-中性条件)。第 3 天,参与者再次检索第 1 天的每段记忆。我们通过积极和消极情绪的面部表情(使用面部肌电图,fEMG)以及自我报告的感受来评估情节的情感基调。中性记忆的积极更新导致积极情绪表达的增加,而消极更新则导致自我报告的消极情绪的增加。这些结果表明,复杂的中性情节记忆可以追溯性地获得情感基调,但其效果并不明显,而且在不同的情感读数中效果也不一致。未来的研究应该探究更新情感记忆的其他方法,从而使记忆的情感发生更深刻的变化。
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引用次数: 0
A pilot study examining whether restricting and resuming specific actions systematically changes symptoms of depression and anxiety. A series of N-of-1 trials. 一项试点研究,探讨限制和恢复特定行动是否会系统性地改变抑郁和焦虑症状。一系列N-of-1试验。
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-03 DOI: 10.1016/j.brat.2024.104536
Nickolai Titov, Blake F. Dear, Olav Nielssen, Victoria Barrett, Rony Kayrouz, Lauren G. Staples

Anxiety and depressive disorders are highly prevalent and a leading cause of disability. Understanding how symptoms develop could lead to new preventive and clinical interventions. This pilot study examined whether systematically restricting specific behaviours (target actions) associated with good psychological health would increase psychological symptoms in healthy participants, and whether resuming those actions would reduce symptoms to baseline levels. Twelve adults participated in a series of N-of-1 trials comprising baseline (A), restriction (B) and recovery (C) phases. Outcomes were assessed weekly using measures of depression (PHQ-9), anxiety (GAD-7), and a validated 15-item measure of target actions (Big 5). Symptoms of depression and anxiety increased significantly from Phase A to Phase B and returned to baseline by the end of Phase C. Increased symptoms during Phase B were only observed in participants who restricted actions by more than 25%. Symptom increases were evident within 2 weeks of restriction, but most participants appeared to take longer to recover to baseline levels. This study demonstrates that reducing the frequency of specific actions may increase symptoms of anxiety and depression, which is reversed when those actions are resumed. This contributes to our understanding of the aetiology, maintenance, and recovery from depression, anxiety, and possibly other disorders.

焦虑症和抑郁症发病率很高,是导致残疾的主要原因之一。了解症状是如何形成的,有助于采取新的预防和临床干预措施。这项试验性研究探讨了系统性地限制与良好心理健康相关的特定行为(目标行为)是否会增加健康参与者的心理症状,以及恢复这些行为是否会将症状降至基线水平。12 名成年人参加了一系列 N-1 试验,包括基线(A)、限制(B)和恢复(C)阶段。每周使用抑郁测量(PHQ-9)、焦虑测量(GAD-7)和经过验证的 15 项目标行动测量(Big 5)对结果进行评估。从 A 阶段到 B 阶段,抑郁和焦虑症状明显增加,到 C 阶段结束时又恢复到基线水平。症状的增加在限制后两周内就很明显,但大多数参与者似乎需要更长时间才能恢复到基线水平。这项研究表明,减少特定行动的频率可能会增加焦虑和抑郁症状,而当恢复这些行动时,症状又会逆转。这有助于我们了解抑郁症、焦虑症以及其他疾病的病因、维持和恢复。
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引用次数: 0
Brief emotion regulation strategies to reduce alcohol craving: Mediating role of state difficulties in emotion regulation 减少酒精渴求的简短情绪调节策略:情绪调节中的状态困难的中介作用
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-04-02 DOI: 10.1016/j.brat.2024.104527
Yi-Chun Chang, Robin L. Rubey, Benjamin O. Ladd

Objective

This study experimentally compared the effects of emotion regulation (ER) strategies on alcohol craving and examined the mediating effect of state difficulties in emotion regulation (S-DER) on the relationship between negative/positive emotion and alcohol craving.

Method

417 participants (76.74% women, Mage = 20.76 years) endorsing past-month heavy/binge drinking were randomly assigned to one of four ER conditions (positive reappraisal, distancing, distraction, and acceptance). Participants completed state assessments, including negative/positive emotion, S-DER, and alcohol craving, prior to (T0) and after (T1) engaging in a negative emotion induction task. Subsequently, participants completed an ER strategy task based on their assigned ER strategy condition and completed a third state assessment (T2).

Results

Time had a significant quadratic effect on alcohol craving, such that craving increased from T0 to T1 and decreased from T1 to T2. There was no significant effect of ER strategy condition on craving. Change in S-DER mediated the relationship between the change in negative/positive emotion and the change in craving, with emotional modulation and emotional acceptance facets of S-DER dominating the mediating effect during negative emotion induction and ER strategy induction, respectively.

Conclusions

Results suggest interventions targeting S-DER's emotional modulation and acceptance facets could reduce acute craving when experiencing undesired emotions.

本研究通过实验比较了情绪调节(ER)策略对酒精渴求的影响,并考察了情绪调节中的状态困难(S-DER)对消极/积极情绪与酒精渴求之间关系的中介作用。方法将417名在过去一个月中大量/酗酒的参与者(76.74%为女性,年龄=20.76岁)随机分配到四种ER条件(积极再评价、疏远、分散注意力和接受)中的一种。参与者在参与负面情绪诱导任务之前(T0)和之后(T1)完成状态评估,包括负面/正面情绪、S-DER和酒精渴求。结果时间对酒精渴求有显著的二次影响,即从 T0 到 T1 酒精渴求增加,从 T1 到 T2 酒精渴求减少。ER策略条件对渴求没有明显影响。S-DER的变化介导了消极/积极情绪变化与渴求变化之间的关系,在消极情绪诱导和ER策略诱导期间,S-DER的情绪调节和情绪接受方面分别主导了介导效应。
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引用次数: 0
Less bang for my buck: Diminished anticipated enjoyment contributes to dysphoria-linked deficit in activity behavioural engagement choice 少花钱多办事预期乐趣的减少导致活动行为参与选择中与焦虑症相关的缺陷
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-03-30 DOI: 10.1016/j.brat.2024.104526
Julie L. Ji , Colin MacLeod

This study experimentally investigated the role of anticipated enjoyment and effort in mediating dysphoria-related deficit in activity engagement behavioural choice. Using a novel activity information processing task (about a fictional “new” Nintendo Wii sports game called “Tornado Ball”), N = 249 participants (n = 95 High Dysphoria; n = 154 Low Dysphoria) were presented information about the benefits (enjoyable features) and costs (mental and physical effort barriers) as product reviews from another player. The order of cost vs. benefit information was manipulated such that participants either heard cost information before benefit information, or vice versa. They then rated what their anticipated enjoyment and effort will be if they were to play Tornado Ball, before being given the opportunity to choose to try it themselves or not. The High Dysphoria group reported lower anticipated enjoyment (but not higher effort) relative to the Low Dysphoria group, but only when cost information was presented first. Importantly, a moderated mediation showed that the High Dysphoria group reported lower tendency to choose activity engagement (game play) as a function of having lower anticipated enjoyment, but only when cost information was presented first. The present finding indicate that reduced anticipated enjoyment may causally contribute to dysphoria-linked deficits in activity engagement behavioural choice.

本研究通过实验研究了预期的乐趣和努力在调节活动参与行为选择中与焦虑症相关的缺陷方面所起的作用。通过一项新颖的活动信息处理任务(关于一款虚构的 "新 "任天堂 Wii 体育游戏 "龙卷风球"),N = 249 名参与者(n = 95 名高焦虑症患者;n = 154 名低焦虑症患者)从另一名玩家的产品评论中获得了有关益处(令人愉悦的功能)和成本(精神和体力障碍)的信息。成本与益处信息的顺序是可以调整的,参与者可以先听到成本信息,然后再听到益处信息,反之亦然。然后,他们对自己玩龙卷风球的预期乐趣和努力程度进行评分,然后再让他们选择是否亲自尝试。与低焦虑组相比,高焦虑组的预期享受程度较低(但努力程度并不更高),但只有当成本信息首先呈现时才会出现这种情况。重要的是,调节调解显示,高焦虑症组由于预期享受较低而选择参与活动(玩游戏)的倾向较低,但只有当成本信息首先出现时才会出现这种情况。本研究结果表明,预期乐趣的降低可能是导致与焦虑症相关的活动参与行为选择缺陷的因果关系。
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引用次数: 0
Perseveration on suicidal thoughts and images in daily life: An examination of the cognitive model of suicide through a dynamic systems lens 在日常生活中坚持自杀的想法和意象:从动态系统的角度审视自杀认知模式
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-03-27 DOI: 10.1016/j.brat.2024.104524
Megan L. Rogers , Keyne C. Law , Olivia C. Lawrence , Abby A. Mandel

According to the cognitive model of suicide, interactions between hopelessness and attentional biases toward suicidal information create a narrowed attentional focus on suicide as a viable solution, particularly in the presence of life stress, leading to increased suicide risk. This study used a dynamic systems approach to examine the short-term temporal patterns between stress, hopelessness, suicide-specific rumination, and suicidal intent. Adults (N = 237; M = 27.12 years; 62% cisgender women; 87% White/European American) with elevated suicidal ideation completed ecological momentary assessments six times a day for 14 days. A multilevel model approach informed by dynamic systems theory was used to simultaneously assess stable and dynamic temporal processes underlying perceived stress, hopelessness, suicide-specific rumination, and suicidal intent. Each variable demonstrated temporal stability. In support of the cognitive model of suicide, we observed (1) a reciprocal relationship between stress and hopelessness such that stress and hopelessness amplified each other (early-stage processes), and (2) reinforcing loops such that hopelessness, suicide-specific rumination, and suicidal intent amplified each other (later-stage processes). A dynamic systems modeling approach underscored the negative impact of a perpetuating cycle of suicide-specific rumination, deepening hopelessness, and escalating suicidal intent on increasing suicide risk, which may be targets for intervention.

根据自杀认知模型,绝望情绪和对自杀信息的注意偏差之间的相互作用,会缩小对自杀这一可行解决方案的注意范围,尤其是在生活压力较大的情况下,从而导致自杀风险增加。本研究采用动态系统方法研究了压力、绝望、自杀特定反刍和自杀意向之间的短期时间模式。有较高自杀意念的成年人(人数 = 237;男 = 27.12 岁;62% 顺性别女性;87% 白人/欧裔美国人)在 14 天内每天完成六次生态瞬间评估。该研究采用动态系统理论为基础的多层次模型方法,同时评估感知压力、绝望、自杀特定反刍和自杀意向的稳定和动态时间过程。每个变量都表现出时间稳定性。为了支持自杀认知模型,我们观察到:(1)压力和绝望之间存在相互影响的关系,即压力和绝望会相互放大(早期过程);(2)绝望、自杀特定反刍和自杀意向会相互放大(后期过程)。动态系统建模方法强调了自杀特定反刍、绝望情绪加深和自杀意向升级的持续循环对增加自杀风险的负面影响,这可能是干预的目标。
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引用次数: 0
A randomized controlled trial of brief behavioral activation plus savoring for positive affect dysregulation in university students 针对大学生积极情绪失调的简短行为激活加回味随机对照试验
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-03-24 DOI: 10.1016/j.brat.2024.104525
Divya Kumar , Sarah Corner , Richard Kim , Alicia Meuret

Rising rates of depression on university campuses accentuate the need for specific intervention. Interventions targeting disturbances in positive affect, in particular, remain sparse, yet such deficits interfere substantially with functioning and further exacerbate or maintain negative symptoms. The current study aimed to evaluate the impact of a virtual, two-session Behavioral Activation augmented with Savoring (BA + S) intervention compared to an Emotional Awareness (EA) control group in increasing positive affect. Sixty university students with low positive affect were randomized to BA + S or EA and completed 21 days of experience-sampling of positive affect. Weekly measures of positive and negative valence symptoms were assessed at baseline, sessions one and two, and at one-week follow-up. Through a prori analyses utilizing multilevel and multivariate multilevel models, our results demonstrate that daily positive affect measured via experience-sampling significantly improved in BA + S, whereas positive affect did not change for those receiving EA, though the interaction of condition and time was not significant. Furthermore, interactions in weekly variables were significant. Increases in positive valence symptoms (affect, anhedonia, etc.) were only reported for students receiving BA + S but not EA. Negative valence symptoms (affect, depression, general distress) improved in both conditions but with superior improvements in BA + S compared to EA. BA + S shows promise for a scalable and accessible intervention to university students with clinical levels of positive and negative affect. ClinicalTrials ID: NCT05234476.

大学校园中抑郁症发病率的上升凸显了对特定干预措施的需求。特别是针对积极情绪障碍的干预措施仍然很少,但这种缺陷会严重影响人的功能,并进一步加重或维持消极症状。本研究旨在评估虚拟的、为期两节的行为激活与品味(BA + S)干预与情绪认知(EA)对照组相比,对增加积极情绪的影响。60 名积极情绪较低的大学生被随机分配到 BA + S 或 EA 组,并完成了 21 天的积极情绪体验取样。在基线、第一和第二阶段以及一周的随访中,每周对积极情绪和消极情绪症状进行评估。通过利用多层次和多变量多层次模型进行prori分析,我们的结果表明,通过经验取样测量的每日积极情绪在BA + S中得到了显著改善,而接受EA的人的积极情绪则没有变化,尽管条件和时间的交互作用并不显著。此外,每周变量的交互作用也很明显。只有接受 BA + S 而非 EA 的学生的积极情绪症状(情感、失落感等)有所增加。消极情绪症状(情感、抑郁、一般苦恼)在两种情况下都有所改善,但 BA + S 的改善效果优于 EA。BA + S有望成为一种可扩展、易接受的干预措施,适用于具有临床积极和消极情绪水平的大学生。临床试验编号:NCT05234476:NCT05234476。
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引用次数: 0
Ventromedial prefrontal cortex activation and neurofeedback modulation during episodic future thinking for individuals with suicidal thoughts and behaviors 有自杀想法和行为的人在发作性未来思维期间的中内侧前额叶皮层激活和神经反馈调节
IF 4.1 2区 心理学 Q1 PSYCHOLOGY, CLINICAL Pub Date : 2024-03-22 DOI: 10.1016/j.brat.2024.104522
R.L. Aupperle , R. Kuplicki , A. Tsuchiyagaito , E. Akeman , C.A. Sturycz-Taylor , D. DeVille , T. Lasswell , M. Misaki , H. Berg , T.J. McDermott , J. Touthang , E.D. Ballard , C. Cha , D.L. Schacter , M.P. Paulus

Individuals experiencing suicidal thoughts and behaviors (STBs) show less specificity and positivity during episodic future thinking (EFT). Here, we present findings from two studies aiming to (1) further our understanding of how STBs may relate to neural responsivity during EFT and (2) examine the feasibility of modulating EFT-related activation using real-time fMRI neurofeedback (rtfMRI-nf). Study 1 involved 30 individuals with major depressive disorder (MDD; half with STBs) who performed an EFT task during fMRI, for which they imagined personally-relevant future positive, negative, or neutral events. Positive EFT elicited greater ventromedial prefrontal cortex (vmPFC) activation compared to negative EFT. Importantly, the MDD + STB group exhibited reduced vmPFC activation across all EFT conditions compared to MDD-STB; although EFT fluency and subjective experience remained consistent across groups. Study 2 included rtfMRI-nf focused on vmPFC modulation during positive EFT for six participants with MDD + STBs. Results support the feasibility and acceptability of the rtfMRI-nf protocol and quantitative and qualitative observations are provided to help inform future, larger studies aiming to examine similar neurofeedback protocols. Results implicate vmPFC blunting as a promising treatment target for MDD + STBs and suggest rtfMRI-nf as one potential technique to explore for enhancing vmPFC engagement.

有自杀想法和行为(STBs)的人在发作性未来思维(EFT)过程中表现出较低的特异性和积极性。在此,我们将介绍两项研究的结果,旨在:(1)进一步了解 STB 与 EFT 期间神经反应性的关系;(2)研究使用实时 fMRI 神经反馈(rtfMRI-nf)调节 EFT 相关激活的可行性。研究1涉及30名重度抑郁障碍(MDD,其中一半患有STB)患者,他们在进行fMRI检查时执行了一项EFT任务,想象与个人相关的未来积极、消极或中性事件。与消极的 EFT 相比,积极的 EFT 会引起更大的腹外侧前额叶皮层(vmPFC)激活。重要的是,与MDD-STB组相比,MDD + STB组在所有EFT条件下的vmPFC激活都有所降低;尽管各组的EFT流畅度和主观体验保持一致。研究 2 包括 rtfMRI-nf,重点研究六名 MDD + STB 参与者在积极 EFT 期间的 vmPFC 调节。研究结果证明了 rtfMRI-nf 方案的可行性和可接受性,并提供了定量和定性观察结果,为今后旨在研究类似神经反馈方案的更大规模研究提供参考。研究结果表明,vmPFC钝化是治疗MDD + STBs的一个很有前景的治疗目标,并建议将rtfMRI-nf作为一种潜在的技术来探索如何提高vmPFC的参与度。
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Behaviour Research and Therapy
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