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Quantifying urban park use in the USA at scale: empirical estimates of realised park usage using smartphone location data 大规模量化美国城市公园的使用情况:利用智能手机定位数据对公园实际使用情况进行实证估算。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-01 DOI: 10.1016/S2542-5196(24)00125-6
Michael T Young PhD , Swapnil Vispute MS , Stylianos Serghiou PhD MD , Akim Kumok MS , Yash Shah BS , Kevin J Lane PhD , Flannery Black-Ingersoll MPH , Paige Brochu PhD , Monica Bharel MD MPH , Sarah Skenazy MPH , Alan Karthikesalingam PhD MD , Shailesh Bavadekar BE , Mansi Kansal MBA , Tomer Shekel MBA , Evgeniy Gabrilovich PhD , Gregory A Wellenius ScD

Background

A large body of evidence connects access to greenspace with substantial benefits to physical and mental health. In urban settings where access to greenspace can be limited, park access and use have been associated with higher levels of physical activity, improved physical health, and lower levels of markers of mental distress. Despite the potential health benefits of urban parks, little is known about how park usage varies across locations (between or within cities) or over time.

Methods

We estimated park usage among urban residents (identified as residents of urban census tracts) in 498 US cities from 2019 to 2021 from aggregated and anonymised opted-in smartphone location history data. We used descriptive statistics to quantify differences in park usage over time, between cities, and across census tracts within cities, and used generalised linear models to estimate the associations between park usage and census tract level descriptors.

Findings

In spring (March 1 to May 31) 2019, 18·9% of urban residents visited a park at least once per week, with average use higher in northwest and southwest USA, and lowest in the southeast. Park usage varied substantially both within and between cities; was unequally distributed across census tract-level markers of race, ethnicity, income, and social vulnerability; and was only moderately correlated with established markers of census tract greenspace. In spring 2019, a doubling of walking time to parks was associated with a 10·1% (95% CI 5·6–14·3) lower average weekly park usage, adjusting for city and social vulnerability index. The median decline in park usage from spring 2019 to spring 2020 was 38·0% (IQR 28·4–46·5), coincident with the onset of physical distancing policies across much of the country. We estimated that the COVID-19-related decline in park usage was more pronounced for those living further from a park and those living in areas of higher social vulnerability.

Interpretation

These estimates provide novel insights into the patterns and correlates of park use and could enable new studies of the health benefits of urban greenspace. In addition, the availability of an empirical park usage metric that varies over time could be a useful tool for assessing the effectiveness of policies intended to increase such activities.

Funding

Google.

背景:大量证据表明,使用绿地对身心健康大有裨益。在绿地有限的城市环境中,公园的进入和使用与较高水平的体育活动、身体健康的改善以及较低水平的精神压力有关。尽管城市公园具有潜在的健康益处,但人们对公园使用率在不同地点(城市之间或城市内部)或不同时间的变化却知之甚少:我们通过汇总和匿名的智能手机定位历史数据,估算了 2019 年至 2021 年美国 498 个城市的城市居民(城市人口普查区的居民)的公园使用率。我们使用描述性统计来量化公园使用率在不同时期、不同城市之间以及城市内不同人口普查区之间的差异,并使用广义线性模型来估计公园使用率与人口普查区级别描述符之间的关联:2019 年春季(3 月 1 日至 5 月 31 日),18%-9% 的城市居民每周至少游览一次公园,美国西北部和西南部的平均使用率较高,东南部最低。在城市内部和城市之间,公园使用率差异很大;在人口普查区一级的种族、民族、收入和社会脆弱性指标中,公园使用率分布不均;与人口普查区绿地的既定指标仅有适度相关性。在2019年春季,根据城市和社会脆弱性指数进行调整后,步行到公园的时间每增加一倍,平均每周公园使用率就会降低10-1%(95% CI 5-6-14-3)。从 2019 年春季到 2020 年春季,公园使用率的中位数下降了 38-0%(IQR 28-4-46-5),这与全国大部分地区开始实施物理距离政策相吻合。我们估计,与 COVID-19 相关的公园使用率下降对于那些居住在距离公园较远的地区和那些居住在社会脆弱性较高的地区的人来说更为明显:这些估计结果为了解公园使用的模式和相关因素提供了新的视角,有助于对城市绿地的健康益处进行新的研究。此外,提供一个随时间变化的经验性公园使用指标,可以成为评估旨在增加此类活动的政策效果的有用工具:资助:谷歌
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引用次数: 0
Confronting heat-related illnesses and deaths at mass gathering religious and sporting events 在群众聚集的宗教和体育活动中应对与高温有关的疾病和死亡。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-01 DOI: 10.1016/S2542-5196(24)00161-X
Brian McCloskey , Ziad A Memish , Avinash Sharma , Tieble Traore , Salim Parker , Alimuddin Zumla
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引用次数: 0
Health and climate policy 健康与气候政策。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-01 DOI: 10.1016/S2542-5196(24)00173-6
The Lancet Planetary Health
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引用次数: 0
Seasons of smoke and fire: preparing health systems for improved performance before, during, and after wildfires 烟与火的季节:在野火发生之前、期间和之后,让卫生系统为提高绩效做好准备。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-01 DOI: 10.1016/S2542-5196(24)00144-X
Attila J Hertelendy PhD , Courtney Howard MD , Cecilia Sorensen MD , Jamie Ranse PhD , Ejemai Eboreime MD PhD , Sarah Henderson PhD , Jeffrey Tochkin MA , Gregory Ciottone MD

Increased frequency, intensity, and duration of wildfires are intensifying exposure to direct and smoke-related hazards in many areas, leading to evacuation and smoke-related effects on health and health systems that can affect regions extending over thousands of kilometres. Effective preparation and response are currently hampered by inadequate training, continued siloing of disciplines, insufficient finance, and inadequate coordination between health systems and governance at municipal, regional, national, and international levels. This Review highlights the key health and health systems considerations before, during, and after wildfires, and outlines how a health system should respond to optimise population health outcomes now and into the future. The focus is on the implications of wildfires for air quality, mental health, and emergency management, with elements of international policy and finance also addressed. We discuss commonalities of existing climate-resilient health care and disaster management frameworks and integrate them into an approach that addresses issues of financing, leadership and governance, health workforce, health information systems, infrastructure, supply chain, technologies, community interaction and health-care delivery, before, during, and after a wildfire season. This Review is a practical briefing for leaders and health professionals facing severe wildfire seasons and a call to break down silos and join with other disciplines to proactively plan for and fund innovation and coordination in service of a healthier future.

野火发生的频率、强度和持续时间增加,加剧了许多地区暴露于直接危害和烟雾相关危害的程度,导致疏散和烟雾对健康和卫生系统的影响,这些影响可波及数千公里的区域。目前,有效的准备和应对工作受到以下因素的阻碍:培训不足、各学科继续各自为政、资金不足以及市、地区、国家和国际各级卫生系统和治理之间的协调不足。本综述强调了野火发生之前、期间和之后卫生和卫生系统的主要考虑因素,并概述了卫生系统应如何应对,以优化现在和未来的人口健康结果。重点是野火对空气质量、心理健康和应急管理的影响,同时也涉及国际政策和财政等因素。我们讨论了现有抵御气候变化的医疗保健和灾害管理框架的共性,并将其整合到一种方法中,以解决野火季节之前、期间和之后的融资、领导力和治理、医疗劳动力、医疗信息系统、基础设施、供应链、技术、社区互动和医疗保健服务等问题。本综述为面临严重野火季节的领导者和卫生专业人员提供了一份实用的简报,并呼吁打破各自为政的局面,与其他学科联合起来,积极规划和资助创新与协调,为更健康的未来服务。
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引用次数: 0
Where and how to invest in greenspace for optimal health benefits: a systematic review of greenspace morphology and human health relationships 在何处以及如何投资绿地以获得最佳健康效益:绿地形态与人类健康关系的系统回顾。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-08-01 DOI: 10.1016/S2542-5196(24)00140-2
Huaqing Wang PhD , Simin Gholami MSc , Wenyan Xu PhD , Amirhossein Samavatekbatan MSc , Ole Sleipness PhD , Prof Louis G Tassinary PhD JD

Research on the relationship between greenspace morphology and health is a growing field that informs the spatial design of greenspace to enhance health outcomes. This study reviews the current progress, methodologies, and knowledge gaps in this area. From a database search of 272 940 English articles and 39 053 Chinese articles up to April 18, 2024, we identified 22 and 7 studies on the topic for further evaluation. Predominantly cross-sectional and neighbourhood-scale analyses were conducted using land cover maps ranging from 0·25 to 100 meters in resolution. Six primary characteristics of greenspace morphology have been studied, including size, shape, fragmentation, connectedness, aggregation, and diversity. While associations between greenspace morphology and health outcomes have been observed, both their reliability and generalisability remain suggestive due to ecological study designs and heterogeneity among studies. Future research should prioritise individual-level prospective cohorts and intervention studies. Exploring mechanisms linking greenspace morphology and health, determining optimal map resolution, and distinguishing it from greenness magnitude in statistical analysis is essential. This evidence is crucial for health-promoting greenspace planning and should be routinely integrated into urban epidemiological research.

绿地形态与健康之间关系的研究是一个不断发展的领域,它为绿地的空间设计提供信息,以提高健康效果。本研究回顾了这一领域目前的进展、方法和知识差距。通过数据库检索截至 2024 年 4 月 18 日的 272 940 篇英文文章和 39 053 篇中文文章,我们分别发现了 22 项和 7 项有关该主题的研究,以供进一步评估。我们使用分辨率从 0-25 米到 100 米不等的土地覆被图进行了以横断面和街区尺度为主的分析。研究了绿地形态的六个主要特征,包括大小、形状、破碎度、连通性、聚集度和多样性。虽然已观察到绿地形态与健康结果之间的关联,但由于生态研究设计和研究之间的异质性,其可靠性和普遍性仍有待进一步研究。未来的研究应优先考虑个人层面的前瞻性队列和干预研究。探索绿地形态与健康之间的关联机制、确定最佳地图分辨率以及在统计分析中区分绿地形态与绿化程度至关重要。这些证据对于促进健康的绿地规划至关重要,应定期纳入城市流行病学研究。
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引用次数: 0
Political restoration 政治恢复。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-07-01 DOI: 10.1016/S2542-5196(24)00146-3
The Lancet Planetary Health
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引用次数: 0
Stemming the rising tide of Vibrio disease 遏制弧菌疾病的上升趋势。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-07-01 DOI: 10.1016/S2542-5196(24)00124-4
Craig Baker-Austin PhD , Prof Iain Lake PhD , Elizabeth Archer PhD , Rachel Hartnell PhD , Prof Joaquin Trinanes PhD , Prof Jaime Martinez-Urtaza PhD

Globally, the diverse bacterial genus Vibrio is the most important group of bacterial pathogens found in marine and coastal waters. These bacteria can cause an array of human infections via direct exposure to seawater or through the consumption of seafoods grown and cultivated in coastal and estuarine settings. Crucially, we appear to be on the cusp of an alarming global increase in Vibrio disease. A worldwide increase in seafood consumption, the globalisation of the seafood trade, the more frequent use of coastal waters for recreational activities, and climate change all contribute to greatly increased human health risks associated with Vibrio bacteria. Coupled with a population that is increasingly susceptible to more serious infections, we are likely to see a marked increase in both reported cases and fatalities in the near future. In this Personal View, we discuss and frame this important and emerging public health issue, and provide various contemporary case studies to illustrate how the risk profiles of pathogenic Vibrio bacteria have transformed in the past two decades—particularly in response to changing climatological and meteorological drivers such as marine coastal warming and extreme weather events such as heatwaves and storms. We share various approaches to help better understand and manage risks associated with these bacteria, ranging from risk mitigation strategies to enhanced epidemiological monitoring and surveillance approaches.

在全球范围内,弧菌属细菌种类繁多,是海洋和沿海水域中最重要的细菌病原体。这些细菌可通过直接接触海水或通过食用在沿海和河口环境中生长和养殖的海产品引起一系列人类感染。至关重要的是,我们似乎正处于弧菌疾病在全球范围内惊人增长的边缘。全球海产品消费量的增加、海产品贸易的全球化、更频繁地使用沿海水域进行娱乐活动以及气候变化,都会大大增加与弧菌有关的人类健康风险。再加上人们越来越容易受到更严重的感染,在不久的将来,我们很可能会看到报告病例和死亡人数都会显著增加。在这篇《个人观点》中,我们讨论并阐述了这一新出现的重要公共卫生问题,并提供了各种当代案例研究,以说明致病性弧菌的风险特征在过去二十年中发生了怎样的变化--尤其是在应对气候和气象变化的驱动因素(如海洋沿岸变暖以及热浪和风暴等极端天气事件)方面。我们分享了有助于更好地了解和管理与这些细菌有关的风险的各种方法,从风险缓解战略到强化流行病学监测和监控方法。
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引用次数: 0
High ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia: an observational study 孕期环境温度过高与儿童患急性淋巴细胞白血病的风险:一项观察性研究。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-07-01 DOI: 10.1016/S2542-5196(24)00121-9
Tormod Rogne PhD , Rong Wang PhD , Pin Wang PhD , Nicole C Deziel PhD , Prof Catherine Metayer PhD , Prof Joseph L Wiemels PhD , Kai Chen PhD , Joshua L Warren PhD , Prof Xiaomei Ma PhD

Background

High ambient temperature is increasingly common due to climate change and is associated with risk of adverse pregnancy outcomes. Acute lymphoblastic leukaemia is the most common malignancy in children, the incidence is increasing, and in the USA disproportionately affects Latino children. We aimed to investigate the potential association between high ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia.

Methods

We used data from California birth records (children born from Jan 1, 1982, to Dec 31, 2015) and California Cancer Registry (those diagnosed with childhood cancer in California from Jan 1, 1988, to Dec 31, 2015) to identify acute lymphoblastic leukaemia cases diagnosed in infants and children aged 14 years and younger and controls matched by sex, race, ethnicity, and date of last menstrual period. Ambient temperatures were estimated on a 1-km grid. The association between ambient temperature and acute lymphoblastic leukaemia was evaluated per gestational week, restricted to May–September, adjusting for confounders. Bayesian meta-regression was applied to identify critical exposure windows. For sensitivity analyses, we evaluated a 90-day pre-pregnancy period (assuming no direct effect before pregnancy), adjusted for relative humidity and particulate matter less than 2·5 microns in aerodynamic diameter, and constructed an alternatively matched dataset for exposure contrast by seasonality.

Findings

6849 cases of childhood acute lymphoblastic leukaemia were identified and, of these, 6258 had sufficient data for study inclusion. We also included 307 579 matched controls. Most of the study population were male (174 693 [55·7%] of the 313 837 included in the study) and of Latino ethnicity (174 906 [55·7%]). The peak association between ambient temperature and risk of acute lymphoblastic leukaemia was observed in gestational week 8, where a 5°C increase was associated with an odds ratio of 1·07 (95% CI 1·04–1·11). A slightly larger effect was seen among Latino children (OR 1·09 [95% CI 1·04–1·14]) than non-Latino White children (OR 1·05 [1·00–1·11]). The sensitivity analyses supported the results of the main analysis.

Interpretation

Our findings suggest an association between high ambient temperature in early pregnancy and risk of childhood acute lymphoblastic leukaemia. Further replication and investigation of mechanistic pathways might inform mitigation strategies.

Funding

Yale Center on Climate Change and Health, The National Center for Advancing Translational Science, National Institutes of Health.

背景:由于气候变化,环境温度过高的现象越来越普遍,这与不良妊娠结局的风险有关。急性淋巴细胞白血病是儿童最常见的恶性肿瘤,发病率正在上升,在美国,拉丁裔儿童的发病率更高。我们旨在研究孕期环境温度过高与儿童急性淋巴细胞白血病风险之间的潜在关联:我们利用加州出生记录(1982 年 1 月 1 日至 2015 年 12 月 31 日出生的儿童)和加州癌症登记(1988 年 1 月 1 日至 2015 年 12 月 31 日在加州确诊为儿童癌症的儿童)中的数据,确定了确诊为急性淋巴细胞白血病的 14 岁及以下婴幼儿病例,以及按性别、种族、民族和末次月经日期匹配的对照组。环境温度按 1 公里网格估算。环境温度与急性淋巴细胞白血病之间的关系按孕周进行评估,时间仅限于 5 月至 9 月,并对混杂因素进行了调整。采用贝叶斯元回归法确定关键暴露窗口。在敏感性分析中,我们评估了孕前 90 天(假设孕前无直接影响),调整了相对湿度和空气动力直径小于 2-5 微米的颗粒物,并构建了一个替代匹配数据集,用于按季节性进行暴露对比:我们发现了 6849 例儿童急性淋巴细胞白血病病例,其中 6258 例病例的数据足以纳入研究。我们还纳入了 307 579 例匹配对照。研究对象中大部分为男性(313 837 例研究对象中的 174 693 例[55-7%])和拉丁裔(174 906 例[55-7%])。环境温度与罹患急性淋巴细胞白血病风险之间的关系在孕 8 周达到顶峰,温度每升高 5°C,几率比为 1-07(95% CI 1-04-1-11)。拉丁裔儿童的影响(OR 1-09 [95% CI 1-04-1-14])略大于非拉丁裔白人儿童(OR 1-05 [1-00-1-11])。敏感性分析支持主要分析的结果:我们的研究结果表明,孕早期环境温度过高与儿童急性淋巴细胞白血病的发病风险有关。对机理途径的进一步复制和调查可能会为缓解策略提供依据:耶鲁大学气候变化与健康中心、国家促进转化科学中心、美国国立卫生研究院。
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引用次数: 0
All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis 全因、心血管和呼吸系统死亡率与野火相关臭氧:多国两阶段时间序列分析。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-07-01 DOI: 10.1016/S2542-5196(24)00117-7
Gongbo Chen PhD , Prof Yuming Guo PhD , Prof Xu Yue PhD , Rongbin Xu PhD , Wenhua Yu MPH , Tingting Ye MSc , Prof Shilu Tong PhD , Prof Antonio Gasparrini PhD , Prof Michelle L Bell PhD , Prof Ben Armstrong PhD , Prof Joel Schwartz PhD , Prof Jouni J K Jaakkola PhD , Eric Lavigne PhD , Prof Paulo Hilario Nascimento Saldiva PhD , Prof Haidong Kan PhD , Dominic Royé PhD , Aleš Urban PhD , Prof Ana Maria Vicedo-Cabrera PhD , Aurelio Tobias PhD , Prof Bertil Forsberg PhD , Ariana Zeka

Background

Wildfire activity is an important source of tropospheric ozone (O3) pollution. However, no study to date has systematically examined the associations of wildfire-related O3 exposure with mortality globally.

Methods

We did a multicountry two-stage time series analysis. From the Multi-City Multi-Country (MCC) Collaborative Research Network, data on daily all-cause, cardiovascular, and respiratory deaths were obtained from 749 locations in 43 countries or areas, representing overlapping periods from Jan 1, 2000, to Dec 31, 2016. We estimated the daily concentration of wildfire-related O3 in study locations using a chemical transport model, and then calibrated and downscaled O3 estimates to a resolution of 0·25° × 0·25° (approximately 28 km2 at the equator). Using a random-effects meta-analysis, we examined the associations of short-term wildfire-related O3 exposure (lag period of 0–2 days) with daily mortality, first at the location level and then pooled at the country, regional, and global levels. Annual excess mortality fraction in each location attributable to wildfire-related O3 was calculated with pooled effect estimates and used to obtain excess mortality fractions at country, regional, and global levels.

Findings

Between 2000 and 2016, the highest maximum daily wildfire-related O3 concentrations (≥30 μg/m3) were observed in locations in South America, central America, and southeastern Asia, and the country of South Africa. Across all locations, an increase of 1 μg/m3 in the mean daily concentration of wildfire-related O3 during lag 0–2 days was associated with increases of 0·55% (95% CI 0·29 to 0·80) in daily all-cause mortality, 0·44% (–0·10 to 0·99) in daily cardiovascular mortality, and 0·82% (0·18 to 1·47) in daily respiratory mortality. The associations of daily mortality rates with wildfire-related O3 exposure showed substantial geographical heterogeneity at the country and regional levels. Across all locations, estimated annual excess mortality fractions of 0·58% (95% CI 0·31 to 0·85; 31 606 deaths [95% CI 17 038 to 46 027]) for all-cause mortality, 0·41% (–0·10 to 0·91; 5249 [–1244 to 11 620]) for cardiovascular mortality, and 0·86% (0·18 to 1·51; 4657 [999 to 8206]) for respiratory mortality were attributable to short-term exposure to wildfire-related O3.

Interpretation

In this study, we observed an increase in all-cause and respiratory mortality associated with short-term wildfire-related O3 exposure. Effective risk and smoke management strategies should be implemented to protect the public from the impacts of wildfires.

Funding

Australian Research Council and the Australian National Health and Medical Research Council.

背景:野火活动是对流层臭氧(O3)污染的重要来源:野火活动是对流层臭氧(O3)污染的一个重要来源。然而,迄今为止还没有一项研究系统地考察了全球范围内野火相关的臭氧暴露与死亡率之间的关系:我们进行了多国两阶段时间序列分析。从多城市多国家(MCC)合作研究网络中,我们从 43 个国家或地区的 749 个地点获得了每日全因死亡、心血管死亡和呼吸系统死亡的数据,这些数据代表了 2000 年 1 月 1 日至 2016 年 12 月 31 日的重叠时期。我们使用化学传输模型估算了研究地点与野火相关的臭氧日浓度,然后将臭氧估算值校准并降级到 0-25° × 0-25° 的分辨率(赤道约 28 平方公里)。我们采用随机效应荟萃分析法,首先在地点层面,然后在国家、地区和全球层面进行汇总,研究了与野火相关的短期臭氧暴露(滞后期为 0-2 天)与日死亡率之间的关系。利用汇集效应估计值计算出每个地点与野火相关的臭氧导致的年超额死亡率,并利用该估计值得出国家、地区和全球层面的超额死亡率:2000年至2016年期间,在南美洲、中美洲、亚洲东南部和南非等地观测到了与野火相关的最高日臭氧浓度(≥30 μg/m3)。在所有地区,在滞后的 0-2 天内,与野火相关的臭氧日平均浓度每增加 1 μg/m3 就会导致每日全因死亡率增加 0-55%(95% CI 0-29 至 0-80),每日心血管死亡率增加 0-44%(-0-10 至 0-99),每日呼吸系统死亡率增加 0-82%(0-18 至 1-47)。在国家和地区层面上,每日死亡率与野火相关臭氧暴露的关联显示出很大的地域异质性。在所有地区,估计每年全因死亡率超额死亡率为 0-58%(95% CI 0-31 至 0-85;31 606 例死亡 [95% CI 17 038 至 46 027]),心血管死亡率为 0-41%(-0-10 至 0-91;5249 [-1244 至 11 620]),呼吸系统死亡率为 0-86%(0-18 至 1-51;4657 [999 至 8206]):在这项研究中,我们观察到短期暴露于与野火相关的 O3 会增加全因死亡率和呼吸系统死亡率。应实施有效的风险和烟雾管理策略,以保护公众免受野火的影响:澳大利亚研究委员会和澳大利亚国家健康与医学研究委员会。
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引用次数: 0
Urgent optimism for planetary health: lessons from the video game industry 对地球健康的迫切乐观:电子游戏产业的启示。
IF 24.1 1区 医学 Q1 ENVIRONMENTAL SCIENCES Pub Date : 2024-07-01 DOI: 10.1016/S2542-5196(24)00110-4
Fatimah Ahamad , Jemilah Mahmood , Oliver Lacey-Hall , Menaka Ganeson , Hannah Zuhairah Ariff , Tai-Jie Lim
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Lancet Planetary Health
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