Pub Date : 2024-08-01DOI: 10.1016/S2542-5196(24)00125-6
Michael T Young PhD , Swapnil Vispute MS , Stylianos Serghiou PhD MD , Akim Kumok MS , Yash Shah BS , Kevin J Lane PhD , Flannery Black-Ingersoll MPH , Paige Brochu PhD , Monica Bharel MD MPH , Sarah Skenazy MPH , Alan Karthikesalingam PhD MD , Shailesh Bavadekar BE , Mansi Kansal MBA , Tomer Shekel MBA , Evgeniy Gabrilovich PhD , Gregory A Wellenius ScD
Background
A large body of evidence connects access to greenspace with substantial benefits to physical and mental health. In urban settings where access to greenspace can be limited, park access and use have been associated with higher levels of physical activity, improved physical health, and lower levels of markers of mental distress. Despite the potential health benefits of urban parks, little is known about how park usage varies across locations (between or within cities) or over time.
Methods
We estimated park usage among urban residents (identified as residents of urban census tracts) in 498 US cities from 2019 to 2021 from aggregated and anonymised opted-in smartphone location history data. We used descriptive statistics to quantify differences in park usage over time, between cities, and across census tracts within cities, and used generalised linear models to estimate the associations between park usage and census tract level descriptors.
Findings
In spring (March 1 to May 31) 2019, 18·9% of urban residents visited a park at least once per week, with average use higher in northwest and southwest USA, and lowest in the southeast. Park usage varied substantially both within and between cities; was unequally distributed across census tract-level markers of race, ethnicity, income, and social vulnerability; and was only moderately correlated with established markers of census tract greenspace. In spring 2019, a doubling of walking time to parks was associated with a 10·1% (95% CI 5·6–14·3) lower average weekly park usage, adjusting for city and social vulnerability index. The median decline in park usage from spring 2019 to spring 2020 was 38·0% (IQR 28·4–46·5), coincident with the onset of physical distancing policies across much of the country. We estimated that the COVID-19-related decline in park usage was more pronounced for those living further from a park and those living in areas of higher social vulnerability.
Interpretation
These estimates provide novel insights into the patterns and correlates of park use and could enable new studies of the health benefits of urban greenspace. In addition, the availability of an empirical park usage metric that varies over time could be a useful tool for assessing the effectiveness of policies intended to increase such activities.
{"title":"Quantifying urban park use in the USA at scale: empirical estimates of realised park usage using smartphone location data","authors":"Michael T Young PhD , Swapnil Vispute MS , Stylianos Serghiou PhD MD , Akim Kumok MS , Yash Shah BS , Kevin J Lane PhD , Flannery Black-Ingersoll MPH , Paige Brochu PhD , Monica Bharel MD MPH , Sarah Skenazy MPH , Alan Karthikesalingam PhD MD , Shailesh Bavadekar BE , Mansi Kansal MBA , Tomer Shekel MBA , Evgeniy Gabrilovich PhD , Gregory A Wellenius ScD","doi":"10.1016/S2542-5196(24)00125-6","DOIUrl":"10.1016/S2542-5196(24)00125-6","url":null,"abstract":"<div><h3>Background</h3><p>A large body of evidence connects access to greenspace with substantial benefits to physical and mental health. In urban settings where access to greenspace can be limited, park access and use have been associated with higher levels of physical activity, improved physical health, and lower levels of markers of mental distress. Despite the potential health benefits of urban parks, little is known about how park usage varies across locations (between or within cities) or over time.</p></div><div><h3>Methods</h3><p>We estimated park usage among urban residents (identified as residents of urban census tracts) in 498 US cities from 2019 to 2021 from aggregated and anonymised opted-in smartphone location history data. We used descriptive statistics to quantify differences in park usage over time, between cities, and across census tracts within cities, and used generalised linear models to estimate the associations between park usage and census tract level descriptors.</p></div><div><h3>Findings</h3><p>In spring (March 1 to May 31) 2019, 18·9% of urban residents visited a park at least once per week, with average use higher in northwest and southwest USA, and lowest in the southeast. Park usage varied substantially both within and between cities; was unequally distributed across census tract-level markers of race, ethnicity, income, and social vulnerability; and was only moderately correlated with established markers of census tract greenspace. In spring 2019, a doubling of walking time to parks was associated with a 10·1% (95% CI 5·6–14·3) lower average weekly park usage, adjusting for city and social vulnerability index. The median decline in park usage from spring 2019 to spring 2020 was 38·0% (IQR 28·4–46·5), coincident with the onset of physical distancing policies across much of the country. We estimated that the COVID-19-related decline in park usage was more pronounced for those living further from a park and those living in areas of higher social vulnerability.</p></div><div><h3>Interpretation</h3><p>These estimates provide novel insights into the patterns and correlates of park use and could enable new studies of the health benefits of urban greenspace. In addition, the availability of an empirical park usage metric that varies over time could be a useful tool for assessing the effectiveness of policies intended to increase such activities.</p></div><div><h3>Funding</h3><p>Google.</p></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 8","pages":"Pages e564-e573"},"PeriodicalIF":24.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542519624001256/pdfft?md5=60d6073253211cf4bf97941c5fd35055&pid=1-s2.0-S2542519624001256-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1016/S2542-5196(24)00161-X
Brian McCloskey , Ziad A Memish , Avinash Sharma , Tieble Traore , Salim Parker , Alimuddin Zumla
{"title":"Confronting heat-related illnesses and deaths at mass gathering religious and sporting events","authors":"Brian McCloskey , Ziad A Memish , Avinash Sharma , Tieble Traore , Salim Parker , Alimuddin Zumla","doi":"10.1016/S2542-5196(24)00161-X","DOIUrl":"10.1016/S2542-5196(24)00161-X","url":null,"abstract":"","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 8","pages":"Pages e522-e523"},"PeriodicalIF":24.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S254251962400161X/pdfft?md5=dd61622d6235a8526b59a69e63ccbc17&pid=1-s2.0-S254251962400161X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1016/S2542-5196(24)00144-X
Attila J Hertelendy PhD , Courtney Howard MD , Cecilia Sorensen MD , Jamie Ranse PhD , Ejemai Eboreime MD PhD , Sarah Henderson PhD , Jeffrey Tochkin MA , Gregory Ciottone MD
Increased frequency, intensity, and duration of wildfires are intensifying exposure to direct and smoke-related hazards in many areas, leading to evacuation and smoke-related effects on health and health systems that can affect regions extending over thousands of kilometres. Effective preparation and response are currently hampered by inadequate training, continued siloing of disciplines, insufficient finance, and inadequate coordination between health systems and governance at municipal, regional, national, and international levels. This Review highlights the key health and health systems considerations before, during, and after wildfires, and outlines how a health system should respond to optimise population health outcomes now and into the future. The focus is on the implications of wildfires for air quality, mental health, and emergency management, with elements of international policy and finance also addressed. We discuss commonalities of existing climate-resilient health care and disaster management frameworks and integrate them into an approach that addresses issues of financing, leadership and governance, health workforce, health information systems, infrastructure, supply chain, technologies, community interaction and health-care delivery, before, during, and after a wildfire season. This Review is a practical briefing for leaders and health professionals facing severe wildfire seasons and a call to break down silos and join with other disciplines to proactively plan for and fund innovation and coordination in service of a healthier future.
{"title":"Seasons of smoke and fire: preparing health systems for improved performance before, during, and after wildfires","authors":"Attila J Hertelendy PhD , Courtney Howard MD , Cecilia Sorensen MD , Jamie Ranse PhD , Ejemai Eboreime MD PhD , Sarah Henderson PhD , Jeffrey Tochkin MA , Gregory Ciottone MD","doi":"10.1016/S2542-5196(24)00144-X","DOIUrl":"10.1016/S2542-5196(24)00144-X","url":null,"abstract":"<div><p>Increased frequency, intensity, and duration of wildfires are intensifying exposure to direct and smoke-related hazards in many areas, leading to evacuation and smoke-related effects on health and health systems that can affect regions extending over thousands of kilometres. Effective preparation and response are currently hampered by inadequate training, continued siloing of disciplines, insufficient finance, and inadequate coordination between health systems and governance at municipal, regional, national, and international levels. This Review highlights the key health and health systems considerations before, during, and after wildfires, and outlines how a health system should respond to optimise population health outcomes now and into the future. The focus is on the implications of wildfires for air quality, mental health, and emergency management, with elements of international policy and finance also addressed. We discuss commonalities of existing climate-resilient health care and disaster management frameworks and integrate them into an approach that addresses issues of financing, leadership and governance, health workforce, health information systems, infrastructure, supply chain, technologies, community interaction and health-care delivery, before, during, and after a wildfire season. This Review is a practical briefing for leaders and health professionals facing severe wildfire seasons and a call to break down silos and join with other disciplines to proactively plan for and fund innovation and coordination in service of a healthier future.</p></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 8","pages":"Pages e588-e602"},"PeriodicalIF":24.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S254251962400144X/pdfft?md5=ca61939164508981cbf490e8194e1e81&pid=1-s2.0-S254251962400144X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-01DOI: 10.1016/S2542-5196(24)00140-2
Huaqing Wang PhD , Simin Gholami MSc , Wenyan Xu PhD , Amirhossein Samavatekbatan MSc , Ole Sleipness PhD , Prof Louis G Tassinary PhD JD
Research on the relationship between greenspace morphology and health is a growing field that informs the spatial design of greenspace to enhance health outcomes. This study reviews the current progress, methodologies, and knowledge gaps in this area. From a database search of 272 940 English articles and 39 053 Chinese articles up to April 18, 2024, we identified 22 and 7 studies on the topic for further evaluation. Predominantly cross-sectional and neighbourhood-scale analyses were conducted using land cover maps ranging from 0·25 to 100 meters in resolution. Six primary characteristics of greenspace morphology have been studied, including size, shape, fragmentation, connectedness, aggregation, and diversity. While associations between greenspace morphology and health outcomes have been observed, both their reliability and generalisability remain suggestive due to ecological study designs and heterogeneity among studies. Future research should prioritise individual-level prospective cohorts and intervention studies. Exploring mechanisms linking greenspace morphology and health, determining optimal map resolution, and distinguishing it from greenness magnitude in statistical analysis is essential. This evidence is crucial for health-promoting greenspace planning and should be routinely integrated into urban epidemiological research.
{"title":"Where and how to invest in greenspace for optimal health benefits: a systematic review of greenspace morphology and human health relationships","authors":"Huaqing Wang PhD , Simin Gholami MSc , Wenyan Xu PhD , Amirhossein Samavatekbatan MSc , Ole Sleipness PhD , Prof Louis G Tassinary PhD JD","doi":"10.1016/S2542-5196(24)00140-2","DOIUrl":"10.1016/S2542-5196(24)00140-2","url":null,"abstract":"<div><p>Research on the relationship between greenspace morphology and health is a growing field that informs the spatial design of greenspace to enhance health outcomes. This study reviews the current progress, methodologies, and knowledge gaps in this area. From a database search of 272 940 English articles and 39 053 Chinese articles up to April 18, 2024, we identified 22 and 7 studies on the topic for further evaluation. Predominantly cross-sectional and neighbourhood-scale analyses were conducted using land cover maps ranging from 0·25 to 100 meters in resolution. Six primary characteristics of greenspace morphology have been studied, including size, shape, fragmentation, connectedness, aggregation, and diversity. While associations between greenspace morphology and health outcomes have been observed, both their reliability and generalisability remain suggestive due to ecological study designs and heterogeneity among studies. Future research should prioritise individual-level prospective cohorts and intervention studies. Exploring mechanisms linking greenspace morphology and health, determining optimal map resolution, and distinguishing it from greenness magnitude in statistical analysis is essential. This evidence is crucial for health-promoting greenspace planning and should be routinely integrated into urban epidemiological research.</p></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 8","pages":"Pages e574-e587"},"PeriodicalIF":24.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542519624001402/pdfft?md5=8aeff536e0444db8879aef24075350d1&pid=1-s2.0-S2542519624001402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Globally, the diverse bacterial genus Vibrio is the most important group of bacterial pathogens found in marine and coastal waters. These bacteria can cause an array of human infections via direct exposure to seawater or through the consumption of seafoods grown and cultivated in coastal and estuarine settings. Crucially, we appear to be on the cusp of an alarming global increase in Vibrio disease. A worldwide increase in seafood consumption, the globalisation of the seafood trade, the more frequent use of coastal waters for recreational activities, and climate change all contribute to greatly increased human health risks associated with Vibrio bacteria. Coupled with a population that is increasingly susceptible to more serious infections, we are likely to see a marked increase in both reported cases and fatalities in the near future. In this Personal View, we discuss and frame this important and emerging public health issue, and provide various contemporary case studies to illustrate how the risk profiles of pathogenic Vibrio bacteria have transformed in the past two decades—particularly in response to changing climatological and meteorological drivers such as marine coastal warming and extreme weather events such as heatwaves and storms. We share various approaches to help better understand and manage risks associated with these bacteria, ranging from risk mitigation strategies to enhanced epidemiological monitoring and surveillance approaches.
{"title":"Stemming the rising tide of Vibrio disease","authors":"Craig Baker-Austin PhD , Prof Iain Lake PhD , Elizabeth Archer PhD , Rachel Hartnell PhD , Prof Joaquin Trinanes PhD , Prof Jaime Martinez-Urtaza PhD","doi":"10.1016/S2542-5196(24)00124-4","DOIUrl":"10.1016/S2542-5196(24)00124-4","url":null,"abstract":"<div><p>Globally, the diverse bacterial genus <em>Vibrio</em> is the most important group of bacterial pathogens found in marine and coastal waters. These bacteria can cause an array of human infections via direct exposure to seawater or through the consumption of seafoods grown and cultivated in coastal and estuarine settings. Crucially, we appear to be on the cusp of an alarming global increase in <em>Vibrio</em> disease. A worldwide increase in seafood consumption, the globalisation of the seafood trade, the more frequent use of coastal waters for recreational activities, and climate change all contribute to greatly increased human health risks associated with <em>Vibrio</em> bacteria. Coupled with a population that is increasingly susceptible to more serious infections, we are likely to see a marked increase in both reported cases and fatalities in the near future. In this Personal View, we discuss and frame this important and emerging public health issue, and provide various contemporary case studies to illustrate how the risk profiles of pathogenic <em>Vibrio</em> bacteria have transformed in the past two decades—particularly in response to changing climatological and meteorological drivers such as marine coastal warming and extreme weather events such as heatwaves and storms. We share various approaches to help better understand and manage risks associated with these bacteria, ranging from risk mitigation strategies to enhanced epidemiological monitoring and surveillance approaches.</p></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 7","pages":"Pages e515-e520"},"PeriodicalIF":24.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542519624001244/pdfft?md5=99fbdf66e0e636f803f7c0279ab3a9f6&pid=1-s2.0-S2542519624001244-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1016/S2542-5196(24)00121-9
Tormod Rogne PhD , Rong Wang PhD , Pin Wang PhD , Nicole C Deziel PhD , Prof Catherine Metayer PhD , Prof Joseph L Wiemels PhD , Kai Chen PhD , Joshua L Warren PhD , Prof Xiaomei Ma PhD
Background
High ambient temperature is increasingly common due to climate change and is associated with risk of adverse pregnancy outcomes. Acute lymphoblastic leukaemia is the most common malignancy in children, the incidence is increasing, and in the USA disproportionately affects Latino children. We aimed to investigate the potential association between high ambient temperature in pregnancy and risk of childhood acute lymphoblastic leukaemia.
Methods
We used data from California birth records (children born from Jan 1, 1982, to Dec 31, 2015) and California Cancer Registry (those diagnosed with childhood cancer in California from Jan 1, 1988, to Dec 31, 2015) to identify acute lymphoblastic leukaemia cases diagnosed in infants and children aged 14 years and younger and controls matched by sex, race, ethnicity, and date of last menstrual period. Ambient temperatures were estimated on a 1-km grid. The association between ambient temperature and acute lymphoblastic leukaemia was evaluated per gestational week, restricted to May–September, adjusting for confounders. Bayesian meta-regression was applied to identify critical exposure windows. For sensitivity analyses, we evaluated a 90-day pre-pregnancy period (assuming no direct effect before pregnancy), adjusted for relative humidity and particulate matter less than 2·5 microns in aerodynamic diameter, and constructed an alternatively matched dataset for exposure contrast by seasonality.
Findings
6849 cases of childhood acute lymphoblastic leukaemia were identified and, of these, 6258 had sufficient data for study inclusion. We also included 307 579 matched controls. Most of the study population were male (174 693 [55·7%] of the 313 837 included in the study) and of Latino ethnicity (174 906 [55·7%]). The peak association between ambient temperature and risk of acute lymphoblastic leukaemia was observed in gestational week 8, where a 5°C increase was associated with an odds ratio of 1·07 (95% CI 1·04–1·11). A slightly larger effect was seen among Latino children (OR 1·09 [95% CI 1·04–1·14]) than non-Latino White children (OR 1·05 [1·00–1·11]). The sensitivity analyses supported the results of the main analysis.
Interpretation
Our findings suggest an association between high ambient temperature in early pregnancy and risk of childhood acute lymphoblastic leukaemia. Further replication and investigation of mechanistic pathways might inform mitigation strategies.
Funding
Yale Center on Climate Change and Health, The National Center for Advancing Translational Science, National Institutes of Health.
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Pub Date : 2024-07-01DOI: 10.1016/S2542-5196(24)00117-7
Gongbo Chen PhD , Prof Yuming Guo PhD , Prof Xu Yue PhD , Rongbin Xu PhD , Wenhua Yu MPH , Tingting Ye MSc , Prof Shilu Tong PhD , Prof Antonio Gasparrini PhD , Prof Michelle L Bell PhD , Prof Ben Armstrong PhD , Prof Joel Schwartz PhD , Prof Jouni J K Jaakkola PhD , Eric Lavigne PhD , Prof Paulo Hilario Nascimento Saldiva PhD , Prof Haidong Kan PhD , Dominic Royé PhD , Aleš Urban PhD , Prof Ana Maria Vicedo-Cabrera PhD , Aurelio Tobias PhD , Prof Bertil Forsberg PhD , Ariana Zeka
Background
Wildfire activity is an important source of tropospheric ozone (O3) pollution. However, no study to date has systematically examined the associations of wildfire-related O3 exposure with mortality globally.
Methods
We did a multicountry two-stage time series analysis. From the Multi-City Multi-Country (MCC) Collaborative Research Network, data on daily all-cause, cardiovascular, and respiratory deaths were obtained from 749 locations in 43 countries or areas, representing overlapping periods from Jan 1, 2000, to Dec 31, 2016. We estimated the daily concentration of wildfire-related O3 in study locations using a chemical transport model, and then calibrated and downscaled O3 estimates to a resolution of 0·25° × 0·25° (approximately 28 km2 at the equator). Using a random-effects meta-analysis, we examined the associations of short-term wildfire-related O3 exposure (lag period of 0–2 days) with daily mortality, first at the location level and then pooled at the country, regional, and global levels. Annual excess mortality fraction in each location attributable to wildfire-related O3 was calculated with pooled effect estimates and used to obtain excess mortality fractions at country, regional, and global levels.
Findings
Between 2000 and 2016, the highest maximum daily wildfire-related O3 concentrations (≥30 μg/m3) were observed in locations in South America, central America, and southeastern Asia, and the country of South Africa. Across all locations, an increase of 1 μg/m3 in the mean daily concentration of wildfire-related O3 during lag 0–2 days was associated with increases of 0·55% (95% CI 0·29 to 0·80) in daily all-cause mortality, 0·44% (–0·10 to 0·99) in daily cardiovascular mortality, and 0·82% (0·18 to 1·47) in daily respiratory mortality. The associations of daily mortality rates with wildfire-related O3 exposure showed substantial geographical heterogeneity at the country and regional levels. Across all locations, estimated annual excess mortality fractions of 0·58% (95% CI 0·31 to 0·85; 31 606 deaths [95% CI 17 038 to 46 027]) for all-cause mortality, 0·41% (–0·10 to 0·91; 5249 [–1244 to 11 620]) for cardiovascular mortality, and 0·86% (0·18 to 1·51; 4657 [999 to 8206]) for respiratory mortality were attributable to short-term exposure to wildfire-related O3.
Interpretation
In this study, we observed an increase in all-cause and respiratory mortality associated with short-term wildfire-related O3 exposure. Effective risk and smoke management strategies should be implemented to protect the public from the impacts of wildfires.
Funding
Australian Research Council and the Australian National Health and Medical Research Council.
{"title":"All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis","authors":"Gongbo Chen PhD , Prof Yuming Guo PhD , Prof Xu Yue PhD , Rongbin Xu PhD , Wenhua Yu MPH , Tingting Ye MSc , Prof Shilu Tong PhD , Prof Antonio Gasparrini PhD , Prof Michelle L Bell PhD , Prof Ben Armstrong PhD , Prof Joel Schwartz PhD , Prof Jouni J K Jaakkola PhD , Eric Lavigne PhD , Prof Paulo Hilario Nascimento Saldiva PhD , Prof Haidong Kan PhD , Dominic Royé PhD , Aleš Urban PhD , Prof Ana Maria Vicedo-Cabrera PhD , Aurelio Tobias PhD , Prof Bertil Forsberg PhD , Ariana Zeka","doi":"10.1016/S2542-5196(24)00117-7","DOIUrl":"10.1016/S2542-5196(24)00117-7","url":null,"abstract":"<div><h3>Background</h3><p>Wildfire activity is an important source of tropospheric ozone (O<sub>3</sub>) pollution. However, no study to date has systematically examined the associations of wildfire-related O<sub>3</sub> exposure with mortality globally.</p></div><div><h3>Methods</h3><p>We did a multicountry two-stage time series analysis. From the Multi-City Multi-Country (MCC) Collaborative Research Network, data on daily all-cause, cardiovascular, and respiratory deaths were obtained from 749 locations in 43 countries or areas, representing overlapping periods from Jan 1, 2000, to Dec 31, 2016. We estimated the daily concentration of wildfire-related O<sub>3</sub> in study locations using a chemical transport model, and then calibrated and downscaled O<sub>3</sub> estimates to a resolution of 0·25° × 0·25° (approximately 28 km<sup>2</sup> at the equator). Using a random-effects meta-analysis, we examined the associations of short-term wildfire-related O<sub>3</sub> exposure (lag period of 0–2 days) with daily mortality, first at the location level and then pooled at the country, regional, and global levels. Annual excess mortality fraction in each location attributable to wildfire-related O<sub>3</sub> was calculated with pooled effect estimates and used to obtain excess mortality fractions at country, regional, and global levels.</p></div><div><h3>Findings</h3><p>Between 2000 and 2016, the highest maximum daily wildfire-related O<sub>3</sub> concentrations (≥30 μg/m<sup>3</sup>) were observed in locations in South America, central America, and southeastern Asia, and the country of South Africa. Across all locations, an increase of 1 μg/m<sup>3</sup> in the mean daily concentration of wildfire-related O<sub>3</sub> during lag 0–2 days was associated with increases of 0·55% (95% CI 0·29 to 0·80) in daily all-cause mortality, 0·44% (–0·10 to 0·99) in daily cardiovascular mortality, and 0·82% (0·18 to 1·47) in daily respiratory mortality. The associations of daily mortality rates with wildfire-related O<sub>3</sub> exposure showed substantial geographical heterogeneity at the country and regional levels. Across all locations, estimated annual excess mortality fractions of 0·58% (95% CI 0·31 to 0·85; 31 606 deaths [95% CI 17 038 to 46 027]) for all-cause mortality, 0·41% (–0·10 to 0·91; 5249 [–1244 to 11 620]) for cardiovascular mortality, and 0·86% (0·18 to 1·51; 4657 [999 to 8206]) for respiratory mortality were attributable to short-term exposure to wildfire-related O<sub>3</sub>.</p></div><div><h3>Interpretation</h3><p>In this study, we observed an increase in all-cause and respiratory mortality associated with short-term wildfire-related O<sub>3</sub> exposure. Effective risk and smoke management strategies should be implemented to protect the public from the impacts of wildfires.</p></div><div><h3>Funding</h3><p>Australian Research Council and the Australian National Health and Medical Research Council.</p></div>","PeriodicalId":48548,"journal":{"name":"Lancet Planetary Health","volume":"8 7","pages":"Pages e452-e462"},"PeriodicalIF":24.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2542519624001177/pdfft?md5=f2c36ec34d941fad1a4883a23deecc67&pid=1-s2.0-S2542519624001177-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}