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Evaluating Heat Risk: Comparing On-Site WBGT Measurements Versus Smartphone Application Estimates 热风险评估:现场 WBGT 测量值与智能手机应用估算值的比较
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-25 DOI: 10.1029/2025GH001347
A. J. Grundstein, S. W. Yeargin, E. R. Cooper, L. Cargile, J. Clark, R. M. Lopez, K. C. Miller, A. M. Montalvo, S. Scarneo-Miller, R. L. Stearns

Exertional heat illness poses a significant risk for workers, athletes, and military personnel participating in outdoor activities during hot weather. An important component of heat safety is to monitor environmental conditions through heat stress indices like the wet bulb globe temperature (WBGT) and adjust activity as conditions get progressively hotter. Traditionally, on-site (OS) WBGT measurement devices are used, but phone applications (PAs) offering WBGT estimates have emerged as a potential alternative. However, there is little information on how closely PA-derived WBGTs match OS measurements to guide decision-making. This study compared the PA-derived Zelus WBGT estimates with OS measurements from Kestrel 5400 devices and their impact on activity modification categorization. A 2-month observational study collected 1,056 paired (OS and PA) WBGT measurements from 26 high schools across 11 states in the United States and over diverse surfaces (artificial turf 53%, natural grass 44%, others 3%). WBGT values were categorized using regional activity modification thresholds to account for local acclimatization. Our findings indicated that while exhibiting high correlation (r = 0.89), PA WBGTs were on average about 1°C cooler, with differences of 2–3°C at higher WBGTs. Findings were similar for both grass and artificial turf surfaces. Further, significant discrepancies were observed in WBGT-based activity modification categories, with the PA more frequently indicating lower modification categories compared to OS devices, especially in hotter conditions. In light of these findings, the PA requires further validation prior to its adoption as a replacement for OS measurements.

劳累性中暑对在炎热天气参加户外活动的工人、运动员和军事人员构成重大风险。热安全的一个重要组成部分是通过湿球温度(WBGT)等热应力指数监测环境状况,并随着环境逐渐变热而调整活动。传统上,使用现场(OS) WBGT测量设备,但提供WBGT估计的电话应用程序(PAs)已成为潜在的替代方案。然而,关于pa衍生的wbgt与OS测量值的匹配程度如何以指导决策的信息很少。本研究比较了pa衍生的Zelus WBGT估计值与Kestrel 5400设备的OS测量值及其对活动改变分类的影响。一项为期2个月的观察性研究从美国11个州的26所高中收集了1056对(OS和PA) WBGT测量数据,这些数据来自不同的表面(人造草坪53%,天然草坪44%,其他3%)。利用区域活动修改阈值对WBGT值进行分类,以解释当地的适应性。我们的研究结果表明,尽管具有高相关性(r = 0.89),但PA wbgt平均温度较低约1°C,较高wbgt的差异为2-3°C。草皮和人造草坪表面的研究结果相似。此外,在基于wbgt的活动修改类别中观察到显著差异,与OS设备相比,PA更频繁地表示较低的修改类别,特别是在较热的条件下。鉴于这些发现,在采用PA作为OS测量的替代品之前,需要进一步验证。
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引用次数: 0
A Geospatial Perspective Toward the Role of Wild Bird Migrations and Global Poultry Trade in the Spread of Highly Pathogenic Avian Influenza H5N1 从地理空间角度看野鸟迁徙和全球家禽贸易在高致病性H5N1禽流感传播中的作用
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-25 DOI: 10.1029/2024GH001296
Mehak Jindal, Haley Stone, Samsung Lim, C. Raina MacIntyre

This study presents the interplay between wild bird migrations and global poultry trade in the unprecedented spread of highly pathogenic avian influenza, particularly the H5N1 clade 2.3.4.4b strain, across the world and diverse ecosystems from 2020 to 2023. We theorized the role of migratory birds in spreading pathogens as various wild bird species traverse major flyways between the northern and southern hemispheres. Simultaneously, we analyzed the global poultry trade data to assess its role in H5N1's anthropogenic spread, highlighting how human economic activities intersect with natural avian behaviors in disease dynamics. Lastly, we conducted spatial hotspot analysis to identify areas of significant clustering of H5N1 outbreak points over different bird families from 2003 to 2023. This approach provides a strong framework for identifying specific regions at higher risk for H5N1 outbreaks and upon which to further evaluate these patterns with targeted intervention studies and research into what is driving these patterns. Our findings indicate that both the poultry sector and wild bird migrations significantly contribute to global H5N1 transmission, which helps better understanding of H5N1 transmission mechanisms when combined with ecological, epidemiological, and socio-economic perspectives. The results are intended to inform policy-making and strategic planning in wildlife conservation and the poultry trade to improve public health and animal welfare globally.

本研究提出了野鸟迁徙和全球家禽贸易在高致病性禽流感(特别是H5N1分支2.3.4.4b毒株)在2020年至2023年在全球和不同生态系统中前所未有的传播中的相互作用。我们将候鸟在传播病原体中的作用理论化,因为各种野生鸟类穿越南北半球之间的主要飞行路线。同时,我们分析了全球家禽贸易数据,以评估其在H5N1的人为传播中的作用,强调人类经济活动与自然鸟类行为在疾病动力学中的交叉关系。最后,我们进行了空间热点分析,以确定2003 - 2023年不同鸟类科的H5N1爆发点的显著聚集区域。这种方法为确定H5N1暴发风险较高的特定地区提供了一个强有力的框架,并在此基础上通过有针对性的干预研究和研究推动这些模式的原因进一步评估这些模式。我们的研究结果表明,家禽业和野鸟迁徙都显著促进了H5N1的全球传播,这有助于从生态、流行病学和社会经济角度更好地了解H5N1的传播机制。研究结果旨在为野生动物保护和家禽贸易的决策和战略规划提供信息,以改善全球公共卫生和动物福利。
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引用次数: 0
Fire Intensity and spRead forecAst (FIRA): A Machine Learning Based Fire Spread Prediction Model for Air Quality Forecasting Application 火灾强度和蔓延预测(FIRA):基于机器学习的火灾蔓延预测模型在空气质量预测中的应用
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-22 DOI: 10.1029/2024GH001253
Wei-Ting Hung, Barry Baker, Patrick C. Campbell, Youhua Tang, Ravan Ahmadov, Johana Romero-Alvarez, Haiqin Li, Jordan Schnell

Fire activities introduce hazardous impacts on the environment and public health by emitting various chemical species into the atmosphere. Most operational air quality forecast (AQF) models estimate smoke emissions based on the latest available satellite fire products, which may not represent real-time fire behaviors without considering fire spread. Hence, a novel machine learning (ML) based fire spread forecast model, the Fire Intensity and spRead forecAst (FIRA), is developed for AQF model applications. FIRA aims to improve the performance of AQF models by providing realistic, dynamic fire characteristics including the spatial distribution and intensity of fire radiative power (FRP). In this study, data sets in 2020 over the continental United States (CONUS) and a historical California fire in 2024 are used for model training and evaluation. For application assessment, FIRA FRP predictions are applied to the Unified Forecast System coupled with smoke (UFS-Smoke) model as inputs, focusing on a California fire case in September 2020. Results show that FIRA captures fire spread with R-squared (R2) near 0.7 and good spatial similarity (∼95%). The comparison between UFS-Smoke simulations using near-real-time fire products and FIRA FRP predictions show good agreements, indicating that FIRA can accurately represent future fire activities. Although FIRA generally underestimates fire intensity, the uncertainties can be mitigated by applying scaling factors to FRP values. Use of the scaled FIRA largely outperforms the experimental UFS-Smoke model in predicting aerosol optical depth and the three-dimensional smoke contents, while also demonstrating the ability to improve surface fine particulate matter (PM2.5) concentrations affected by fires.

消防活动向大气中排放各种化学物质,对环境和公众健康产生有害影响。大多数可操作的空气质量预测(AQF)模型基于最新可用的卫星火灾产品来估计烟雾排放,如果不考虑火灾蔓延,这些产品可能无法代表实时火灾行为。因此,针对AQF模型的应用,开发了一种新的基于机器学习(ML)的火灾蔓延预测模型——火灾强度和蔓延预测(FIRA)。FIRA旨在通过提供真实的、动态的火灾特征,包括火灾辐射功率(FRP)的空间分布和强度,来提高AQF模型的性能。在本研究中,使用2020年美国大陆(CONUS)的数据集和2024年加利福尼亚历史火灾的数据集进行模型训练和评估。为了进行应用评估,将FIRA FRP预测应用于统一预测系统,并将烟雾(UFS-Smoke)模型作为输入,重点关注2020年9月加州的一起火灾案例。结果表明,FIRA捕捉火灾蔓延的R-squared (R2)接近0.7,具有良好的空间相似性(约95%)。使用近实时火灾产品的UFS-Smoke模拟与FIRA FRP预测之间的比较显示出良好的一致性,表明FIRA可以准确地代表未来的火灾活动。尽管FIRA通常低估了火灾强度,但可以通过对FRP值应用比例因子来减轻不确定性。在预测气溶胶光学深度和三维烟雾含量方面,使用缩放FIRA在很大程度上优于实验UFS-Smoke模型,同时也证明了改善受火灾影响的表面细颗粒物(PM2.5)浓度的能力。
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引用次数: 0
Seasonal Bird Migration Could Explain Regional Synchronicity and Amplification in Human West Nile Virus Case Numbers 季节性鸟类迁徙可以解释人类西尼罗病毒病例数的区域同步性和扩增性。
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-20 DOI: 10.1029/2024GH001194
Franklin W. Schwartz, Motomu Ibaraki, Hiroko M. Hort

West Nile virus (WNV) is a zoonotic virus with a mosquito-avian transmission cycle having occasional spillover to mammals. A network analysis of annual log-transformed WNV case numbers (2003–2022) generated four spatially and temporally coherent clusters among 48 U.S. states and six Canadian provinces. Cluster 1 and Cluster 3 were the largest groups corresponding to the Central Flyway and the closely associated Eastern Flyway (with an east-coast subset). Cluster 2 and Cluster 4 corresponded with less-well defined segments of a distinctly different Western Flyway. Thus, clustering can be explained by migratory pathways of terrestrial birds. We investigated avian involvement in the spread of WNV from potential sources in the southern U.S. Analyses revealed consistent patterns in log-transformed case numbers of human WNV. This study highlights the significant role of migratory birds in shaping the spatiotemporal patterns of WNV incidence across North America. However, the observed variability in incidence also likely reflects the interplay of other factors including local environmental conditions, mosquito populations, and regional variations in both migratory and non-migratory bird populations.

西尼罗河病毒(WNV)是一种人畜共患病毒,其传播周期为蚊子-鸟类传播,偶尔会波及哺乳动物。对年度对数转换 WNV 病例数(2003-2022 年)进行网络分析后,在美国 48 个州和加拿大 6 个省中产生了 4 个空间和时间上一致的群组。群组 1 和群组 3 是最大的群组,分别对应于中部蝇道和密切相关的东部蝇道(含东海岸子集)。第 2 组和第 4 组对应的是定义不太明确的西部飞禽通道。因此,陆地鸟类的迁徙路径可以解释这种聚类现象。我们调查了鸟类参与美国南部潜在来源的 WNV 传播的情况。这项研究强调了候鸟在形成北美地区 WNV 发病时空模式中的重要作用。然而,观察到的发病率变化也可能反映了其他因素的相互作用,包括当地环境条件、蚊子种群以及候鸟和非候鸟种群的地区差异。
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引用次数: 0
Regional Difference in the Association Between Long-Term PM and Cardiovascular Disease Incidence and Potential Determinants of the Difference 长期PM与心血管疾病发病率之间的区域差异及差异的潜在决定因素
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-19 DOI: 10.1029/2024GH001245
Ok-Jin Kim, Sun-Young Kim

While short-term studies of the adverse effects of air pollution have found regional differences, there has been insufficient evidence from long-term studies. This study investigated the spatial variation of the association between long-term exposure to particulate matter (PM) air pollution and cardiovascular disease (CVD) incidence and their relevant regional characteristics. We selected 155,017 adults who have lived over 13 years in each of the 16 regions of South Korea from the National Health Insurance Service-National Sample Cohort. We assessed the individual long-term exposure as a 5-year average concentration at district-level residential addresses estimated by previously validated exposure prediction models. We applied time-dependent Cox-proportional hazard models to explore the spatial variation of long-term PM exposure's association with CVD incidence. After adjusting for individual-level characteristics, we estimated the region-specific hazard ratios (HRs) of incident CVD per 10 μg/m3 increase in PM10 and PM2.5. Then, we calculated the correlation coefficients between region-specific HRs and 80 regional attributes in 13 categories across 16 regions to identify the related regional characteristics. Region-specific HRs of CVD incidence for PM showed considerable variation in magnitude and direction across 16 regions. HRs of PM10 and PM2.5 were higher in major urban areas and lower in rural areas. Urbanicity and emission sources exhibited significant correlations with HRs of overall CVD. Our findings offer an opportunity to explore regional characteristics that derive the difference in air pollution-associated health effects and help us provide guidance to target specific characteristics to avoid the adverse health effects of air pollution.

虽然对空气污染不利影响的短期研究发现了地区差异,但长期研究的证据不足。本研究探讨了长期暴露于空气污染颗粒物(PM)与心血管疾病(CVD)发病率相关性的空间变异及其相关区域特征。我们从国民健康保险服务国家样本队列中选择了韩国16个地区中每个地区生活超过13年的155,017名成年人。我们通过先前验证的暴露预测模型评估了个人长期暴露作为区级住宅地址的5年平均浓度。我们应用时间相关的Cox-proportional风险模型来探讨长期PM暴露与心血管疾病发病率之间的空间变化关系。在调整了个人水平的特征后,我们估计了PM10和PM2.5每增加10 μg/m3时发生心血管疾病的区域特异性风险比(HRs)。然后,我们计算了16个地区的13个类别的80个区域属性与区域特定人力资源的相关系数,以确定相关的区域特征。PM的CVD发病率的地区特异性hr在大小和方向上在16个地区有相当大的差异。主要城市地区PM10和PM2.5的hr较高,农村地区hr较低。城市化程度和排放源与总体CVD的hr呈显著相关。我们的研究结果提供了一个机会来探索产生空气污染相关健康影响差异的区域特征,并帮助我们提供针对特定特征的指导,以避免空气污染对健康的不利影响。
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引用次数: 0
Thank You to Our GeoHealth 2024 Reviewers 感谢我们的地球健康2024审稿人
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-18 DOI: 10.1029/2025GH001412
Thanh H. Nguyen

Peer-review is the foundation and the safeguard of scientific research. Without the dedication of our reviewers, the journal would not have been successful. In 2024, 231 reviewers completed the review for 238 manuscripts submitted to GeoHealth. Our reviewers are from all continents except Antarctica. Besides reviewers from North America, China, Europe, and China, we started to have reviewers from India, Latin America, and Africa. GeoHealth editorial board is committed to expanding the readership, authorship, and reviewership to other countries. If you have already reviewed for us, no matter where or who you are, we hope you and your colleagues will consider GeoHeatlh a home for your work. Below is the list of reviewers who completed more than two reviews (noted in italics) or have outstanding quality reviews. Two of our reviewers have been nominated for AGU Best Reviewers awards (*noted with an asterisk).

同行评议是科学研究的基础和保障。如果没有我们审稿人的奉献精神,这本杂志就不会成功。2024年,231名审稿人完成了对提交给GeoHealth的238份手稿的审查。我们的评论家来自除南极洲以外的所有大洲。除了来自北美、中国、欧洲和中国的审稿人,我们开始有来自印度、拉丁美洲和非洲的审稿人。《地球健康》编辑委员会致力于将读者、作者和审稿范围扩大到其他国家。如果您已经为我们进行了评审,无论您在哪里或何人,我们希望您和您的同事将geohealth视为您工作的家园。下面是完成了两次以上评审(以斜体标出)或具有出色质量评审的评审人员的列表。我们的两名评论者被提名为AGU最佳评论者奖(*以星号注明)。
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引用次数: 0
Perceptions of Environmental and Health Effects of Quarry Activities at Klefe in the Ho Municipality of the Volta Region 对沃尔特地区何市克勒夫采石活动的环境和健康影响的认识
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-06 DOI: 10.1029/2024GH001168
Selase Kofi Adanu, Maxwell Kwame Boakye, Shine Francis Gbedemah, Mexoese Nyatuame

Expansion of residential and commercial facilities have contributed to rapid urbanization of Ho municipality. As a result, quarry activities have intensified in Klefe a major stone quarry source for construction. The increased demand for quarry stones has created jobs for many but has also led to the perception of health and environment challenges negatively affecting the people and the natural environment. In view of the extensive quarry activities in the area, the aim of the study was to assess perceptions of effects of quarrying activities on human health and the environment. Stratified random sampling method was used to select respondents to answer questions on a questionnaire and application of a relative importance index to examine what the study community perceive as the most important environmental and health effects of quarrying. Exploratory factor analysis was used to determine relationships existing among environmental hazards and their perceived health effects. Sedimentation, land degradation and injury from quarrying were the main perceived effects of quarrying. Efforts to address any perceived effects of quarrying should focus on sedimentation, land degradation and injury from quarrying.

住宅和商业设施的扩张促进了何市的快速城市化。因此,在主要的建筑石料采石场克莱夫,采石场活动加强了。对采石场石材需求的增加为许多人创造了就业机会,但也导致人们认为健康和环境挑战对人民和自然环境产生了负面影响。鉴于该地区有广泛的采石活动,这项研究的目的是评估人们对采石活动对人类健康和环境的影响的看法。采用分层随机抽样方法选择受访者回答问卷问题,并应用相对重要性指数来检查研究社区认为采石最重要的环境和健康影响。探索性因子分析用于确定环境危害与其感知健康影响之间存在的关系。沉积、土地退化和采石造成的伤害是采石的主要影响。解决任何已知的采石影响的努力应侧重于沉积、土地退化和采石造成的损害。
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引用次数: 0
Times Matter, the Impact of Convective Dust Events on Air Quality in the Greater Phoenix Area, Arizona 时间问题,对流尘埃事件对亚利桑那州大凤凰城地区空气质量的影响
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-03-04 DOI: 10.1029/2024GH001209
K. Ardon-Dryer, T. Aziz

Convective dust events are common in the greater Phoenix area over the summer. These short-duration dust events degrade the air quality and pose a potential health threat to millions. In this study, 93 convective dust events that occurred in July and August 2015 to 2021 were examined to determine their impact on air quality. Seven PM10 stations were used to evaluate the changes in PM10 concentrations over different time intervals (10-min, hourly, and daily). Out of these 93 dust events, only 15.1% had a daily average above the EPA PM10 daily threshold, however, these daily concentrations were 12.8 and 28 times lower compared to hourly and 10-min concentrations (respectively) at the peak of the dust. 10-minute PM10 concentrations were on average 2.2 ± 0.8 times higher than the hourly concentrations. The findings of this study demonstrated that the traditional methods that use daily or hourly averages underestimate the atmospheric PM10 concentrations during short convective dust events and therefore lower the estimated exposure. There is a need to consider shorter time intervals to capture the PM concentrations accurately and highlight the importance of real-time monitoring and accurate characterization of short-duration events to assess their impacts on air quality and human health.

夏季,对流沙尘事件在大凤凰城地区很常见。这些持续时间短的沙尘事件会降低空气质量,对数百万人的健康构成潜在威胁。在这项研究中,研究人员检查了2015年7月和8月至2021年发生的93次对流沙尘事件,以确定它们对空气质量的影响。使用7个PM10监测站来评估不同时间间隔(10分钟、每小时和每天)PM10浓度的变化。在这93起沙尘事件中,只有15.1%的日平均值高于EPA PM10日阈值,然而,这些日浓度分别比沙尘高峰时的每小时和每10分钟浓度低12.8倍和28倍。10分钟PM10浓度平均为小时浓度的2.2±0.8倍。这项研究的结果表明,使用每日或每小时平均值的传统方法低估了短期对流尘埃事件期间大气PM10浓度,因此降低了估计暴露量。有必要考虑缩短时间间隔,以准确捕获PM浓度,并强调实时监测和准确描述短时间事件的重要性,以评估其对空气质量和人类健康的影响。
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引用次数: 0
Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000–2019 2000-2019年全球固体生物燃料排放对环境空气质量和人类健康的长期影响
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-02-27 DOI: 10.1029/2024GH001130
Debatosh B. Partha, Ying Xiong, Noah Prime, Steven J. Smith, Yaoxian Huang

Globally, solid biofuels (SB) have been widely used for household cooking and energy production for decades due to electricity shortages and socio-economic barriers to adopting renewable energy alternatives. This has detrimental effects on air quality, human health, and climate through trace gas and aerosol emissions. Despite numerous studies, the long-term consequences of SB emissions remain poorly understood. Here, we use the Community Earth System Model and the Community Emissions Data System emission inventory to investigate the SB emission impacts on air quality and human health for 2000–2019. Global SB emission increased the ambient PM2.5 (particulate matter with aerodynamic diameters $mathit{le }$2.5 μm) and ozone (O3) concentrations up to 23.61 μg ${upmu }mathrm{g}$/m3 and 13.69 ppbv, with significant effects found in India, China, and the Rest of Asia (ROA). Our study estimates total annual premature deaths (APDs) associated with global SB-attributable PM2.5 and O3 exposure as 1.11 million [95% confidence interval (95% CI): 1.00–1.22 million] in 2000 up to 1.43 million (95% CI: 1.30–1.56 million) in 2019. China's SB emissions and associated APDs have reduced substantially, whereas India and ROA had a major leap in both estimates in 2019 compared to 2000. China's progress in cutting residential SB emissions accounts for its improvements. Our study urges the reduction of SB usage and emissions to potentially improve overall air quality and human health conditions, especially in highly populated, low- and middle-income countries, where the poor air quality and associated health burden attributable to SB emissions are estimated to be higher.

在全球范围内,由于电力短缺和采用可再生能源替代品的社会经济障碍,固体生物燃料(SB)已被广泛用于家庭烹饪和能源生产数十年。这通过微量气体和气溶胶的排放对空气质量、人类健康和气候产生有害影响。尽管进行了大量的研究,但人们对SB排放的长期后果仍然知之甚少。本文利用社区地球系统模型和社区排放数据系统排放清单,研究了2000-2019年SB排放对空气质量和人类健康的影响。全球SB排放增加了环境PM2.5(空气动力学直径≤2.5 μm的颗粒物)和臭氧(O3)浓度,分别达到23.61 μ g ${upmu} mathm {g}$ /m3和13.69 ppbv,其中印度、中国、以及亚洲其他地区(ROA)。我们的研究估计,2000年与全球由sb引起的PM2.5和O3暴露相关的年度过早死亡(apd)总数为111万[95%置信区间(95% CI): 100 - 122万],到2019年为143万(95% CI: 130 - 156万)。中国的SB排放量和相关的apd大幅减少,而印度和ROA在2019年的两项估计都比2000年有了重大飞跃。中国在减少住宅锑排放方面取得的进展是其改善的原因。我们的研究敦促减少SB的使用和排放,以潜在地改善整体空气质量和人类健康状况,特别是在人口密集的低收入和中等收入国家,在这些国家,SB排放导致的空气质量差和相关健康负担估计更高。
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引用次数: 0
Short-Term Associations Between Ambient Ozone and Acute Myocardial Infarction Onset Among Younger Patients: Results From the VIRGO Study 在年轻患者中,环境臭氧与急性心肌梗死发作之间的短期关联:来自VIRGO研究的结果
IF 3.8 2区 医学 Q2 ENVIRONMENTAL SCIENCES Pub Date : 2025-02-18 DOI: 10.1029/2024GH001234
Siqi Zhang, Lingzhi Chu, Yuan Lu, Jing Wei, Robert Dubrow, Sarwat I. Chaudhry, Erica Spatz, Harlan Krumholz, Kai Chen

The association between ambient ozone (O3) and acute myocardial infarction (AMI) onset is unclear, particularly for younger patients and AMI subtypes. This study examined the short-term association of O3 with AMI onset in patients aged 18–55 years and explored differences by AMI subtypes and patient characteristics. We analyzed 2,322 AMI patients admitted to 103 US hospitals (2008–2012). Daily maximum 8-hr O3 concentrations estimated using a spatiotemporal deep learning approach were assigned to participants' home addresses. We used a time-stratified case-crossover design with conditional logistic regression to assess the association between O3 and AMI, adjusting for fine particulate matter, air temperature, and relative humidity. We conducted stratified analyses to examine associations for AMI subtypes and effect modification by sociodemographic status, lifestyle factors, and medical history. An interquartile range (16.6 ppb) increase in O3 concentrations was associated with an increased AMI risk at lag 4 days (odds ratio [OR] = 1.21, 95% confidence interval [CI]: 1.08–1.34) and lag 5 days (OR = 1.11, 95% CI: 1.00–1.24). The association was more pronounced for non-ST-segment elevation AMI and type 2 AMI compared with ST-segment elevation AMI and type 1 AMI, respectively. Stronger O3-AMI associations were observed in non-Hispanic Blacks than in non-Hispanic Whites. Our study provides evidence that short-term O3 exposure is associated with increased AMI risk in younger patients, with varying associations across AMI subtypes. The effect modification by race/ethnicity highlights the need for population-specific intervention strategies.

环境臭氧(O3)与急性心肌梗死(AMI)发病之间的关系尚不清楚,特别是对于年轻患者和AMI亚型。本研究考察了18-55岁患者O3与AMI发病的短期相关性,并探讨了AMI亚型和患者特征的差异。我们分析了美国103家医院(2008-2012年)的2322例AMI患者。使用时空深度学习方法估计的每日最大8小时臭氧浓度被分配到参与者的家庭住址。我们使用时间分层病例交叉设计和条件逻辑回归来评估O3和AMI之间的关系,调整细颗粒物、空气温度和相对湿度。我们进行了分层分析,以检查AMI亚型的相关性以及社会人口状况、生活方式因素和病史对其影响的改变。O3浓度四分位数范围(16.6 ppb)的增加与延迟4天(优势比[OR] = 1.21, 95%可信区间[CI]: 1.08-1.34)和延迟5天(OR = 1.11, 95% CI: 1.00-1.24)时AMI风险增加相关。与st段抬高AMI和1型AMI相比,非st段抬高AMI和2型AMI的相关性更为明显。与非西班牙裔白人相比,非西班牙裔黑人的O3-AMI相关性更强。我们的研究提供了证据,证明短期O3暴露与年轻患者AMI风险增加有关,不同AMI亚型之间存在不同的关联。种族/民族影响的改变突出了针对特定人群的干预策略的必要性。
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