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Lichen planus pigmentosus (LPP) versus erythema dyschromicum perstans (ashy’s dermatosis): A diagnostic dilemma!- Letter to editor 色素性扁平苔藓(LPP)与持久性变色红斑(灰性皮肤病):诊断困境!——致编辑的信
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.074
Shushruta Mohanty, Ekta Mishra, Ajit Surya Mohapatra, Arti Nial
Lichen planus pigmentosus (LPP) versus erythema dyschromicum perstans (ashy’s dermatosis): A diagnostic dilemma!- Letter to editor - IJPO- Print ISSN No: - 2394-6784 Online ISSN No:- 2394-6792 Article DOI No:- 10.18231/j.ijpo.2023.074, Indian Journal of Pathology and Oncology-Indian J Pathol Oncol
色素性扁平苔藓(LPP)与持久性变色红斑(灰性皮肤病):诊断困境!-致编辑信- IJPO- Print ISSN No:- 2394-6784 Online ISSN No:- 2394-6792文章DOI:- 10.18231/j.ijpo.2023.074, Indian Journal of Pathology and Oncology-Indian J Pathol Oncol
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引用次数: 0
An unusual occurrence of synchronous invasive duct carcinoma and multiple myeloma – A case report 侵袭性导管癌合并多发性骨髓瘤1例报告
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.060
Shraddha Mahindra, Meena Pangarkar, Radhika Pagey, Ashish Bohra, Shweta Deulkar, Ankita Tamhane, Anand Pathak, Abhinav Deshpande
The cancer survival rates continue to increase with the passing day owing to advances in diagnostic modalities, therapeutic strategies and the ongoing research. Simultaneously, there is also an increase in the incidence of multiple primary cancers due to the increased survival, long term effects of chemotherapy and/or radiation therapy, higher diagnostic sensitivity and the persisting effects of behavioural and genetic risk factors. Multiple Primary Malignancies (MPM) was first described in 1879 by Billroth. Multiple primary tumours are defined as synchronous or metachronous tumours presenting in the same individual. The neoplasms may be limited to a single organ or may involve multiple anatomical organs. This article presents a case study of a 72-year old female, who was referred to our institute with a history of lump in the left breast and fracture of left clavicle.
由于诊断方式、治疗策略和正在进行的研究的进步,癌症存活率不断增加。同时,由于生存率提高、化疗和/或放射治疗的长期影响、更高的诊断敏感性以及行为和遗传风险因素的持续影响,多种原发性癌症的发病率也有所增加。多发性原发恶性肿瘤(MPM)是由Billroth于1879年首次描述的。多发原发肿瘤被定义为在同一个体出现的同步或异时性肿瘤。肿瘤可能局限于单个器官,也可能累及多个解剖器官。这篇文章提出了一个病例研究的72岁女性,谁被转介到我们研究所的历史肿块在左乳房和左锁骨骨折。
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引用次数: 0
Xanthoma- A case report 黄瘤-一个病例报告
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.063
Tanvi Gokhale, Richa Jindal, Molly Joseph, Kuldeep Kaur, Ankita Nawale
Xanthomas are lesions that are mostly located within the skin or subcutaneous tissue and consist of cholesterol and cholesterol esters. Xanthomas can occur at any site. They are mostly associated with Familial hypercholesterolemia. Although the clinical picture is variable, a high level of LDL cholesterol is the common manifestation. Here we report a case report on multiple Xanthomas in a 19 years old male.
黄瘤是一种主要位于皮肤或皮下组织内的病变,由胆固醇和胆固醇酯组成。黄瘤可发生在任何部位。它们大多与家族性高胆固醇血症有关。虽然临床表现不同,但低密度脂蛋白胆固醇水平高是常见的表现。我们在此报告一位19岁男性多发性黄瘤的病例报告。
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引用次数: 0
Giant lipoma of thigh – Case report of rare tumour 大腿巨大脂肪瘤1例
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.072
Bijan Kumar Saha, Kaushik Saha, Abhishek Jaiswal
Lipomas are tumours which arise from fat tissues and are most common soft tissue tumours. When lipomas turn malignant, they are known as liposarcoma. Lipomas of length greater than 10cm or weight greater than 1000 grams is defined as giant lipoma. Lipomas are mostly asymptomatic at presentation, however when enlarged they can cause symptoms like pain, difficulty in walking due to compression of underlying neurovascular structures. A male patient aged 65 years presented with non-painful swelling in the left thigh which gradually increased in size over last 6 months. The patient did not have any symptoms due to swelling. On examination the swelling was measured 20x15 cm not fixed to skin or underlying bone or soft tissues. No inguinal lymph node was palpable. Contrast Enhanced Magnetic Resonance Imaging (CEMRI) of thigh showed a well circumscribed fat enhanced lesion in the anterior compartment of the left thigh which measures approximately 10.4 x 12.5 x 21.4 cm. The mass lesion was abutting & medially displacing the femoral neurovascular bundle without encasement. Core biopsy from lesion showed adipocytes with background myxoid stromal and skeletal tissue. No cellular pleomorphism mitosis or increased vascularity is evident. Patient underwent excision of tumour with intact capsule under GA via longitudinal elliptical incision. Final histopathology was reported as mature adipocyte separated by thin fibrous septa suggestive of lipoma without any evidence of lipoblasts or atypical nuclear cells. Patient does not have any recurrence after one year of follow up. Surgical excision with intact capsule is treatment of choice for lipoma. In giant lipomas malignant transformation to liposarcoma should be suspected. On imaging malignant transformation is suspected with characteristics like solid component, haemorrhage, infiltration into neurovascular structures which is confirmed on final histopathology report after excision.
脂肪瘤是由脂肪组织产生的肿瘤,是最常见的软组织肿瘤。当脂肪瘤变为恶性时,它们被称为脂肪肉瘤。长度大于10cm或重量大于1000克的脂肪瘤定义为巨大脂肪瘤。脂肪瘤在发病时大多无症状,但扩大后可引起疼痛、行走困难等症状,原因是压迫下层神经血管结构。65岁男性患者表现为左大腿无痛性肿胀,在过去6个月内逐渐增大。患者因肿胀无任何症状。检查时,肿胀测量为20x15 cm,不固定于皮肤或下面的骨骼或软组织。未见腹股沟淋巴结。大腿增强磁共振成像(CEMRI)显示左大腿前房室有一个边界清晰的脂肪增强病变,尺寸约为10.4 x 12.5 x 21.4 cm。肿块病变毗邻;股神经血管束内侧移位,无包膜。病灶核心活检显示脂肪细胞伴黏液样基质和骨组织。未见细胞多形性、有丝分裂或血管增生。患者在GA下经纵向椭圆切口行肿瘤完整包膜切除。最后的组织病理学报告为成熟的脂肪细胞被薄的纤维间隔隔开,提示脂肪瘤,没有任何脂肪母细胞或非典型核细胞的证据。随访1年,无复发。手术切除与完整的囊是治疗脂肪瘤的选择。巨大的脂肪瘤应怀疑恶性转化为脂肪肉瘤。影像学上怀疑为恶性转化,表现为实性成分、出血、神经血管结构浸润等特征,在切除后的最终组织病理学报告中得到证实。
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引用次数: 0
Angiolymphoid hyperplasia with eosinophilia of the tongue – A case report 舌部血管淋巴样增生伴嗜酸性粒细胞增多1例
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.069
Shushruta Mohanty, Sujata Panda, Ajit Surya Mohapatra, Sindhuja Dash
Angiolymphoid lymphoid hyperplasia with eosinophilia (ALHE) represents a heterogenous group of benign vascular lesions that is characterized by proliferation of small to medium sized vascular structures lined by plump epitheloid (histiocytoid)endothelial cells surrounded by mixed inflammatory infiltrate predominantly eosinophils. Intraoral lesions of ALHE are uncommon and tongue involvement is extremely rare. Here we report a case of ALHE of tongue in a 60 yr old female diagnosed on histopathology and confirmed by IHC.
血管淋巴样细胞增生伴嗜酸性粒细胞增多(ALHE)是一种异质性的良性血管病变,其特征是小到中等大小的血管结构增生,周围是丰满的上皮(组织细胞样)内皮细胞,周围是以嗜酸性粒细胞为主的混合炎性浸润。口腔内病变的ALHE是罕见的和舌头累及是极其罕见的。我们在此报告一位60岁女性,经组织病理诊断并经免疫组化证实为舌上ALHE。
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引用次数: 0
Xantho-granulomatous orchitis: A rare case mimicking malignancy 黄叶-肉芽肿性睾丸炎:罕见的恶性肿瘤
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.073
Manjari Kishore, Minakshi Bhardwaj
Testicular mass is an important and frequently encountered finding in hospital setting. Xanthogranulomatous orchitis (XGO) is an uncommon benign lesion and an important cause of testicular mass. It should always be kept as an important differential diagnosis while evaluating testicular lesions. We report a rare case of XGO in a 45-year-old male who presented with a right scrotal swelling. A provisional diagnosis of testicular mass; suspicious of malignancy was given. Right-sided orchidectomy was done. The excised mass was sent for a detailed histopathological evaluation. On histology, a definitive diagnosis of this rare entity was made.
睾丸肿块是一个重要的和经常遇到的发现在医院设置。摘要黄色肉芽肿性睾丸炎(XGO)是一种罕见的良性病变,是睾丸肿块的重要原因。在评估睾丸病变时,应始终将其作为重要的鉴别诊断。我们报告一个罕见的病例XGO在一个45岁的男性谁提出了一个右阴囊肿胀。睾丸肿块的初步诊断;怀疑为恶性肿瘤。行右侧睾丸切除术。切除的肿块被送去做详细的组织病理学评估。在组织学上,对这种罕见的实体做出了明确的诊断。
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引用次数: 0
Xanthogranulomatous appendicitis: A medical marvel 黄色肉芽肿性阑尾炎:医学奇迹
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.068
Neda Ahsan, Bushra Siddiqui, Shahbaz Habib Faridi, Mohammad Feroz Alam, Yahyaa Mansoor
Xanthogranulomatous inflammation (XGI) is a rare but well- described type of chronic inflammation. It was in the genitourinary tract where it was first reported. Any organ can be involved but the most common sites are kidney followed by the gallbladder. Histologically, it can be characterized by a collection of lipids- laden macrophages along with inflammatory infiltrate, with or without cholesterol clefts. XGI is extremely uncommon in the appendix. Due to its atypical presentation, it is usually detected post- operatively. Sami Akbulut et al. published a comprehensive study in January 2021 and reported only 38 patients worldwide. Here, we present a case of a 20 – year old female who came to the OPD with typical signs of Acute Appendicitis diagnosed histopathologically as Xanthogranulomatous appendicitis
摘要黄色肉芽肿性炎症(XGI)是一种罕见但描述良好的慢性炎症。它是在泌尿生殖系统中首次被报道的。任何器官都可能受累,但最常见的部位是肾脏,其次是胆囊。组织学上表现为脂质巨噬细胞聚集伴炎性浸润,伴或不伴胆固醇裂。XGI在阑尾极为罕见。由于其表现不典型,通常在手术后发现。Sami Akbulut等人在2021年1月发表了一项综合研究,报告了全球仅38例患者。在此,我们报告一位20岁的女性,她以典型的急性阑尾炎症状来到门诊,病理上被诊断为黄色肉芽肿性阑尾炎
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引用次数: 0
Comparison of CBNAAT and AFB screening using Ziehl Neelsen stain and fluorescent stain on FNAC sample for rapid diagnosis of tubercular lymphadenitis 采用Ziehl - Neelsen染色和荧光染色对FNAC样品进行CBNAAT和AFB筛选快速诊断结核性淋巴结炎的比较
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.055
Priya Jayakumar, Manju Kaushal, Nandini Duggal
: Tuberculous lymphadenitis is the most common etiology of cervical lymphadenopathy in endemic countries. Fine needle aspiration of palpable lymph nodes is done for rapid diagnosis of tuberculous lymphadenitis This study presents a comparative evaluation of fine needle aspiration cytology (FNAC) with acid fast bacilli screening using Ziehl Neelsen stain, Fluorescent stain with Cartridge based nucleic acid amplification test (CBNAAT) for the rapid diagnosis of tubercular lymphadenitis. : An observational cross sectional study was done over a period of 15 months from January 2020 to March 2021. All newly diagnosed cases of tubercular lymphadenitis irrespective of age and sex were included. Fine needle aspiration was performed from the palpable lymph node. Smears were prepared using Giemsa, Papanicolaou, Ziehl Neelsen and Auramine O stain.Rest of the sample was used for Mycobacterial growth indicator test (MGIT) and CBNAAT. Statistical Analysis was performed using McNemar test. For gold standard, MGIT as well as a composite reference standard on parameters that included MGIT, radiological findings of tuberculosis, Positive Mantoux test and Positive response to ATT seen in the form of complete resolution of clinical and radiological findings. : The diagnostic value of CBNAAT differed with respect to the chosen gold standard. With MGIT as gold standard, CBNAAT had the highest sensitivity, specificity, positive predictive value and negative predictive value. The diagnostic accuracy of CBNAAT was also the highest. Using CRS (Composite Reference standard) as gold standard, CBNAAT showed the highest specificity and positive predictive value. : With CBNAAT showing statistically significant data of a higher diagnostic value in our study as well as showing rapid result, being automated and not subjected to observer interpretation, we conclude that CBNAAT is more efficient in the diagnosis of tubercular lymphadenitis as compared to AFB screening methods. The only limitation of CBNAAT in our study was its ability to show positive results for three atypical mycobacteria due to possible cross contamination.
结核性淋巴结炎是流行国家最常见的宫颈淋巴结病病因。采用可触淋巴结细针穿刺快速诊断结核性淋巴结炎。本研究比较评价细针穿刺细胞学检查(FNAC)与快速酸杆菌筛选(Ziehl Neelsen染色)、核酸扩增荧光染色(CBNAAT)对结核性淋巴结炎的快速诊断价值。在2020年1月至2021年3月的15个月期间进行了一项观察性横断面研究。所有新诊断的结核性淋巴结炎病例不分年龄和性别。从可触及的淋巴结进行细针抽吸。涂片采用Giemsa、Papanicolaou、Ziehl Neelsen和Auramine O染色。其余样品进行分枝杆菌生长指示剂试验(MGIT)和CBNAAT。采用McNemar检验进行统计学分析。对于金标准,MGIT以及参数的复合参考标准,包括MGIT,结核病的放射表现,Mantoux阳性试验和以临床和放射表现的完全解决形式看到的ATT阳性反应。CBNAAT的诊断价值因所选金标准不同而不同。以MGIT为金标准,CBNAAT具有最高的敏感性、特异性、阳性预测值和阴性预测值。CBNAAT的诊断准确率也最高。以CRS (Composite参比标准)为金标准,CBNAAT具有最高的特异性和阳性预测值。鉴于CBNAAT在我们的研究中显示出具有统计学意义的数据,具有更高的诊断价值,并且显示出快速的结果,自动化且不受观察者解释,我们得出结论,与AFB筛查方法相比,CBNAAT在诊断结核性淋巴结炎方面更有效。在我们的研究中,CBNAAT的唯一限制是由于可能的交叉污染,它只能对三种非典型分枝杆菌显示阳性结果。
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引用次数: 0
Pleomorphic adenoma of lateral wall of nose: A case report 鼻侧壁多形性腺瘤1例
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.061
None Ankita, Pankaj Kumar Patel, Mahesh Prasad
Pleomorphic adenoma is a benign mixed tumour most frequently occurring in major salivary glands mainly parotid gland followed by minor salivary glands and lacrimal glands. It occurs rarely in skin and subcutaneous tissue where it had been previously termed as chondroid syringoma. Here we present a case of 22 years female presenting with a small subcutaneous swelling on left lateral wall of nose near medial canthus of left eye slowly progressing in size since 2 years and its histocytocorrelation. Complete excision and histopathology of such lesions is necessary as there may be recurrences and malignant transformation.
多形性腺瘤是一种良性混合性肿瘤,多发生于大唾液腺,以腮腺为主,其次为小唾液腺和泪腺。它很少发生在皮肤和皮下组织,它以前被称为软骨样注射器瘤。我们报告一位22岁的女性,在左眼内眦附近的鼻左侧壁有一个小的皮下肿物,其大小自2年来缓慢扩大,并与组织学有关。由于可能有复发和恶性转化,完全切除和组织病理学检查是必要的。
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引用次数: 0
Morphological perspective of skin adnexal tumours: A case series 皮肤附件肿瘤的形态学观察:一个病例系列
Pub Date : 2023-09-15 DOI: 10.18231/j.ijpo.2023.058
Sarbashis Hota, Sukanya Ghosh, Sneha Jha, Tushar Kanti Das
Adnexal or appendageal tumours of skin comprise an important subcategory of cutaneous neoplasms, although thorough understanding of this entity is still in its early stages. The role of immunohistochemistry in diagnosis is particularly limited, and, it is morphology that actually guides pathologists for clinching diagnosis. Here, we present three uncommon cases of skin adnexal tumours- a case of retiform trichoblastoma, trichilemmal carcinoma and sebaceous carcinoma; especially highlighting the morphological approach of diagnosis and the associated clinical implications based on literature review.
附件或附件皮肤肿瘤是皮肤肿瘤的一个重要亚类,尽管对这一实体的全面了解仍处于早期阶段。免疫组织化学在诊断中的作用特别有限,病理学家对诊断的指导实际上是形态学。在此,我们报告三例罕见的皮肤附件肿瘤——一例网状毛母细胞瘤、毛突癌和皮脂腺癌;特别强调基于文献回顾的形态学诊断方法和相关的临床意义。
{"title":"Morphological perspective of skin adnexal tumours: A case series","authors":"Sarbashis Hota, Sukanya Ghosh, Sneha Jha, Tushar Kanti Das","doi":"10.18231/j.ijpo.2023.058","DOIUrl":"https://doi.org/10.18231/j.ijpo.2023.058","url":null,"abstract":"Adnexal or appendageal tumours of skin comprise an important subcategory of cutaneous neoplasms, although thorough understanding of this entity is still in its early stages. The role of immunohistochemistry in diagnosis is particularly limited, and, it is morphology that actually guides pathologists for clinching diagnosis. Here, we present three uncommon cases of skin adnexal tumours- a case of retiform trichoblastoma, trichilemmal carcinoma and sebaceous carcinoma; especially highlighting the morphological approach of diagnosis and the associated clinical implications based on literature review.","PeriodicalId":486471,"journal":{"name":"Indian Journal of Pathology and Oncology","volume":"2013 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135486216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Indian Journal of Pathology and Oncology
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