To avoid the issue of industrial layout plans in Airport Economic Zones (AEZs) being hard to implement due to mismatched the land supply and demand, it is necessary to clarify industrial layout factors that the government (land supplier) and locating enterprises (land demanders) focus on. This study constructs a AEZ's industrial layout optimization model from the government's perspective and enterprises’ locating utility. Based on the Gale-Shapley algorithm, aiming at eliminating blocking pairs, we establish government-enterprise interacting rules and coordinating mechanisms, corresponding to two types of government-enterprise interactions, namely public consultation and investment promotion joint meeting. According to government transparency and enterprise participation, the optimization model and Agent-Based Model are adopted in the combination to simulate the government-enterprise interactions in the decision-making of industrial layout in AEZ, under two interaction rules of “enterprises provide feedback in one go - the government makes revisions in one go” and “enterprises provide feedback one by one - the government makes revisions one by one”, respectively. By analyzing the changing curves of their objective functions, the equilibrium point where both parties can reach an agreement is identified, and the industrial layout scheme in AEZ is determined that will be mutually accepted. It is found that positive interaction with high government transparency and high enterprise participation will help improve the rationality of the industrial layout in AEZ, maximizing the efficiency of spatial allocation of elements and resources.