Cleft lip and palate (CLP) are prevalent congenital anomalies significantly impacting functional, aesthetic, and psychological aspects during critical developmental stages. Managing CLP requires an interdisciplinary approach involving craniofacial surgeons, pediatricians, otolaryngologists, orthodontists, prosthodontists, and other specialized professionals. Recent biotechnological advances have introduced innovative materials such as autogenous grafts, allografts, and platelet-rich plasma (PRP), known for their enhanced osteoconductivity and osteoinductivity properties. These biotechnologies aim to optimize bone tissue healing and regeneration treatment outcomes and address the multifaceted challenges associated with CLP. Two cases outline a combined approach utilizing homologous lyophilized bone graft with PRP followed by orthodontic movement of the primary canine into the grafted cleft site as a management alternative for CLP patients. This novel procedure provided an effective alternative treatment option for alveolar cleft repair in young children aged 4 to 9. It significantly reduced surgical complications and postoperative discomfort by eliminating the need for a donor site. Three successful options for early alveolar bridge reconstruction include bone matrix and plasma cellular reorganization, orthodontically guided movement of the primary canine through the bone graft, and the natural eruption of the upper permanent canine. These approaches allow patients to eventually complete their orthodontic treatment and oral rehabilitation, resulting in a full, permanent dentition. Moreover, it can positively impact functional and psychological aspects early in treatment, boosting patient confidence.
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