Journal of Psychosomatic Research最新文献_第9页

Mapping the 9-year sleep trajectory and its implications for chronic disease risks among middle-aged and older adults 绘制中老年人 9 年睡眠轨迹及其对慢性疾病风险的影响。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-02 DOI: 10.1016/j.jpsychores.2024.111967

Qian Li , Ngan Yin Chan , Liping Zhang , Samuel Yeung-shan Wong , Xue Yang

Objective

To identify the 9-year trajectories of sleep duration and to assess the relationship between time-dependent sleep duration and sleep trajectories with 14 chronic diseases in adults.

Methods

This study used five waves of data of the China Health and Retirement Longitudinal Survey. Participants with complete sleep duration data and at least one record of 14 chronic diseases were included. The group-based trajectory model was used to identify sleep trajectories from 2011 to 2020. Time-dependent survival analysis and logistic regression were used to examine the relationship between time-dependent sleep duration and sleep trajectories with chronic diseases.

Results

A total of 9063 participants were included, with a mean (standard deviation, SD) sleep duration of 6.37 (1.83) h/d. Sleeping <7 h/d predicted higher risks of 11 chronic diseases at follow-up, with hazard ratios (HR) and 95 % confidence intervals (CI) ranging from 1.71 (1.26–2.33) for psychiatric disease to 1.15 (1.04–1.27) for dyslipidemia. Five sleep trajectories were identified and labeled as group 1–5 based on ascending order of sleep duration. Consistently sleeping <4 h/d (group 1) and 4–6 h/d predicted higher risks of most chronic diseases, with the highest HR (95 %CI) of 3.50 (1.73–6.92) and 2.94 (1.82–4.49) for psychiatric diseases, respectively. Consistently sleeping 6–7 h/d (group 3) predicted higher risks of digestive diseases and arthritis. Decreasing sleep (group 4) predicted higher risks of psychiatric diseases and memory-related diseases.

Conclusions

Consistently sleeping <6 h/d predicted higher risks of most chronic diseases, especially psychiatric diseases. Digestive disease and arthritis were more sensitive to consistently inadequate sleep.

目的确定成人睡眠时间的 9 年轨迹，并评估随时间变化的睡眠时间和睡眠轨迹与 14 种慢性疾病之间的关系：本研究使用了中国健康与退休纵向调查的五波数据。方法：本研究使用了中国健康与退休纵向调查的五次波次数据，纳入了具有完整睡眠时间数据和至少一次 14 种慢性病记录的参与者。采用基于群体的轨迹模型来识别2011年至2020年的睡眠轨迹。采用时间依赖性生存分析和逻辑回归来研究时间依赖性睡眠时间和睡眠轨迹与慢性疾病之间的关系：结果：共纳入 9063 名参与者，平均（标准差，SD）睡眠时间为 6.37 (1.83) h/d。睡眠结论持续睡眠

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引用次数: 0

Network structure of functional somatic symptoms 功能性躯体症状的网络结构

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-11-01 DOI: 10.1016/j.jpsychores.2024.111968

Alexandra Litzenburger , Yannick Rothacher , Kay-Uwe Hanusch , Ulrike Ehlert , Urs M. Nater , Susanne Fischer

Objective

The overlap among functional somatic syndromes (FSS) is substantial, which is why various empirical attempts at an improved understanding of related symptoms have been undertaken. Network analyses are particularly valuable from a clinical point of view, since they focus on the extent to which symptoms expression is co-dependent. The aim of this study was to provide the first estimation of the network structure of symptoms in 17 FSS.

Methods

N = 3054 young adults participated in an online survey. The Questionnaire on Functional Somatic Syndromes (FSSQ) was used to diagnose FSS and to assess related symptoms. The Patient Health Questionnaire (PHQ-9) was used to assess (comorbid) depression. Various R packages were used for network analysis, which yielded correlations between symptoms (edges), symptom groups (communities), and measures of centrality for individual symptoms (e.g., node strength).

Results

The final network had a relatively small number of edges, with small (46.5 %) or small- to medium-sized (47.1 %) correlations. Ten communities were identified: cognitive problems/fatigue/depression, sensory problems, facial pain, head/neck/upper back pain, dizziness/nausea, throat pain/problems with swallowing, chest pain, widespread pain, abdominal pain/problems with digestion, and genital pain. The highest node strength in the network was found for the symptoms “tired”, “down, depressed, or hopeless”, and “tired after minimal exertion”.

Conclusions

The network analyses pointed to ten distinct groups of moderately associated symptoms in individuals with FSS. Fatigue and depression emerged as important symptoms connecting groups. Future studies should test whether (transdiagnostic) interventions specifically targeting these symptoms are particularly potent in alleviating FSS.

目的：功能性躯体综合征（FSS）之间存在大量重叠现象，因此人们尝试通过各种实证研究来加深对相关症状的理解。从临床角度来看，网络分析尤其有价值，因为它侧重于症状表达的共同依赖程度。本研究的目的是首次估算 17 种 FSS 症状的网络结构：方法：3054 名年轻人参与了在线调查。功能性躯体综合征问卷（FSSQ）用于诊断 FSS 和评估相关症状。患者健康问卷（PHQ-9）用于评估（合并）抑郁症。使用各种 R 软件包进行网络分析，得出症状（边）、症状组（群落）之间的相关性，以及单个症状的中心性度量（如节点强度）：最终网络的边缘数量相对较少，相关性较小（46.5%）或中小型（47.1%）。确定了 10 个群组：认知问题/疲劳/抑郁、感觉问题、面部疼痛、头部/颈部/上背部疼痛、头晕/恶心、喉咙痛/吞咽困难、胸痛、广泛性疼痛、腹痛/消化不良和生殖器疼痛。网络中节点强度最高的症状是 "疲倦"、"沮丧、抑郁或绝望 "和 "极度劳累后疲倦"：结论：网络分析显示，FSS 患者有十组不同的中度相关症状。疲劳和抑郁是连接各组的重要症状。未来的研究应测试专门针对这些症状的（跨诊断）干预措施是否能有效缓解 FSS。

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引用次数: 0

Caregiving, caring intensity, and allostatic load: A comparison of caring to others inside and outside the home 护理、护理强度和异质负荷：家庭内外对他人的关爱比较

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-22 DOI: 10.1016/j.jpsychores.2024.111966

Stephen Gallagher , Aoife Bowman Grangel , Ailbhe Dempsey , Siobhán Howard

Objective

Caregiving to a sick or disabled relative is a key chronic stress model in health psychology. However, caregiving is not uniformly stressful, and this study tested whether caregiving effects on life satisfaction and allostatic load varies by caring intensity, i.e., caring within the home, outside the own home, or both (e.g. Dual caring).

Method

Using data from the UK Understanding Society Wave 2, a sample of non-caregivers (N = 3149) and caregivers (N = 562) met inclusion criteria and completed measures of life satisfaction and provided blood samples for capturing endocrine, cardiovascular and immune parameters for assessment of allostatic load.

Results

Dual caregivers had lower life satisfaction compared to non-carers, and other caregiver groups. Further, dual caregivers had higher levels of allostatic load compared to non-carers and those caring within the home and those caring outside the home. These group differences withstood adjustment for several co-variates including gender, education, income and lifestyle factors.

Conclusions

These results confirm that caregiving is not uniformly stressful with dual caring, an index of caring intensity being more damaging for health. The findings are also discussed in relation to the caregiver-control model of chronic stress.

目的护理生病或残疾的亲属是健康心理学中的一种重要的慢性压力模式。本研究测试了护理对生活满意度和异质负荷的影响是否会因护理强度（即在家中护理、在家中以外护理或两者兼有（如双重护理））而有所不同、方法利用英国 "了解社会 "调查第 2 波的数据，抽样调查了符合纳入标准的非照顾者（3149 人）和照顾者（562 人），他们填写了生活满意度调查表，并提供了血液样本，用于采集内分泌、心血管和免疫参数，以评估变态反应负荷。此外，与非照护者、在家照护者和外出照护者相比，双重照护者的异位负荷水平更高。这些群体差异经受住了包括性别、教育、收入和生活方式因素在内的若干共变因素的调整。研究结果还与慢性压力的照顾者-控制模型进行了讨论。

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引用次数: 0

The role of self-efficacy and tangible support in managing depression in fibromyalgia: Expanding social support strategies 自我效能感和有形支持在控制纤维肌痛抑郁中的作用：扩展社会支持策略

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-21 DOI: 10.1016/j.jpsychores.2024.111964

Ajeng Ayu Widiastuti , Adi Atmoko , Nur Eva , Henni Anggraini , Aryudho Widyatno , Riza Amalia , Beny Dwi Pratama

引用次数: 0

Most people do not attribute their burnout symptoms to work 大多数人不会把自己的职业倦怠症状归咎于工作。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-21 DOI: 10.1016/j.jpsychores.2024.111962

Renzo Bianchi , Elin Lindsäter , Tonje Erevik Vollan , Rune Tesaker , Håkon Homme Mathisen , Sigrid Hovdal Øyangen , Benjamin Ek , Una Wen Bø , Emilie Sofie Eilertsen , Tonje Hauglie-Hanssen , Jenny Sofie Hunvik , Maja Hansen Rasul , Irvin Sam Schonfeld

A prevailing belief among researchers is that burnout is a work-specific syndrome induced by intractable job stress. The validity of this belief, however, remains unclear. This cross-sectional study compared burnout with two general conditions, nonspecific psychological distress (NSPD) and exhaustion, in terms of (a) causal attributions to work and (b) associations with 11 job variables (e.g., job satisfaction). The study involved 813 individuals employed in Norway (70.5 % female). Burnout was assessed with the Burnout Assessment Tool; NSPD, with the K6; and exhaustion, with the Karolinska Exhaustion Disorder Scale. Results showed that only 27.7 % of participants with burnout symptoms attributed these symptoms to work. The proportions of individuals ascribing their symptoms to work were similar for NSPD (26.9 %) and exhaustion (27.5 %). The higher one's burnout score, the higher the likelihood of attributing one's burnout, NSPD, and exhaustion symptoms to work. Overall, burnout shared more variance with job variables than did NSPD and exhaustion. Coworker support, job security, and job autonomy constituted notable exceptions. In multiple regression analyses, seven of the 11 job variables predicted NSPD; five predicted burnout and exhaustion. An a posteriori analysis of a nationally balanced quota sample of 591 U.S. employees (48.2 % female) replicated our main finding—only 35.9 % of participants attributed their burnout symptoms to work. This study invites stakeholders to exercise more caution when making etiological inferences about burnout. Assuming that symptoms experienced at work are necessarily caused by work may hinder our ability to mitigate these symptoms. Our findings further question work-centric views of burnout.

研究人员普遍认为，职业倦怠是一种由难以承受的工作压力诱发的工作综合症。然而，这种观点的正确性仍不明确。这项横断面研究比较了职业倦怠与非特异性心理困扰（NSPD）和精疲力竭这两种一般情况在（a）对工作的因果归因和（b）与 11 个工作变量（如工作满意度）之间的关联。这项研究涉及在挪威工作的813人（70.5%为女性）。倦怠感通过倦怠感评估工具进行评估；NSPD通过K6进行评估；精疲力竭则通过卡罗林斯卡精疲力竭障碍量表进行评估。结果显示，只有 27.7% 有职业倦怠症状的参与者将这些症状归咎于工作。将自己的症状归因于工作的人数比例，在 NSPD（26.9%）和精疲力竭（27.5%）方面相似。职业倦怠得分越高，将自己的职业倦怠、NSPD 和疲惫症状归因于工作的可能性就越大。总体而言，工作倦怠与工作变量之间的差异要大于 NSPD 和精疲力竭。同事支持、工作安全感和工作自主性是明显的例外。在多元回归分析中，11 个工作变量中有 7 个预测了 NSPD，5 个预测了职业倦怠和精疲力竭。对 591 名美国雇员（48.2% 为女性）的全国均衡配额样本进行的后验分析重复了我们的主要发现--只有 35.9% 的参与者将其职业倦怠症状归因于工作。这项研究提醒相关人员在对职业倦怠进行病因学推断时要更加谨慎。假设在工作中出现的症状一定是由工作引起的，可能会妨碍我们减轻这些症状的能力。我们的研究结果进一步质疑了以工作为中心的职业倦怠观点。

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引用次数: 0

Childhood maltreatment, cognitive performance, and cognitive decline in middle-aged and older adults with chronic disease: A prospective study 患有慢性疾病的中老年人的童年虐待、认知表现和认知能力下降：一项前瞻性研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-21 DOI: 10.1016/j.jpsychores.2024.111965

Ann Xiuli Chicoine , Howard Chertkow , Jean-Claude Tardif , David Busseuil , Bianca D'Antono

Objectives

Childhood maltreatment (CM) may increase the risk for cognitive deficits and dementia later in life. However, most research has been cross-sectional in nature, has typically focused on specific types of CM, and rarely examined individual differences. The objectives are to evaluate 1) if CM predicts poorer cognitive performance and greater cognitive decline over a 5-year follow-up in older men and women with coronary artery disease (CAD) or other non-cardiovascular (non-CVD) chronic disease, and whether 2) sex and CAD status influence these relations.

Methods

Men and women (N = 1254; 39.6 % women; 65.6 ± 7.0 years old) with CAD or other non-CVD chronic diseases completed the Childhood Trauma Questionnaire Short Form (CTQ-SF). The Montreal Cognitive Assessment (MoCA) was administered twice at 5-year intervals. Main analyses included bivariate correlations, hierarchical analyses and moderation analyses controlling for sociodemographic and health parameters.

Results

CM was experienced by 32 % of the sample, while scores suggestive of cognitive deficits were obtained by 32.7 % and 40.2 % at study onset and follow-up, respectively. CM was associated with significantly lower MoCA scores at study onset (b = −0.013, p = 0.020), but not with change in MoCA over time (b = −0.002, p = 0.796). While MoCA scores did differ as a function of sex and CAD status, the latter did not influence the relations between maltreatment and MoCA.

Conclusions

CM predicted poorer cognitive functioning among older individuals with chronic diseases but did not play a role in any further cognitive decline over the follow-up period. Further research is needed to help understand the mechanisms implicated.

目的：童年虐待（CM）可能会增加日后出现认知障碍和痴呆症的风险。然而，大多数研究都是横断面研究，通常侧重于特定类型的儿童虐待，很少研究个体差异。本研究的目的是评估：1）冠状动脉疾病（CAD）或其他非心血管疾病（non-cardiovascular (non-CVD)）慢性疾病老年男性和女性患者在 5 年随访期间，CM 是否预示着较差的认知表现和较大的认知衰退；2）性别和 CAD 状态是否影响这些关系：患有冠状动脉疾病或其他非心血管疾病慢性病的男性和女性（N = 1254；39.6% 为女性；65.6 ± 7.0 岁）填写了儿童创伤问卷简表（CTQ-SF）。蒙特利尔认知评估（MoCA）每隔 5 年进行两次。主要分析包括双变量相关性分析、层次分析以及控制社会人口学和健康参数的调节分析：32%的样本患有CM，32.7%和40.2%的样本在研究开始和随访时分别获得了提示认知障碍的分数。在研究开始时，CM 与较低的 MoCA 分数明显相关（b = -0.013，p = 0.020），但与 MoCA 随时间的变化无关（b = -0.002，p = 0.796）。虽然MoCA得分因性别和CAD状态而异，但后者并不影响虐待与MoCA之间的关系：CM预示着患有慢性疾病的老年人认知功能较差，但在随访期间并没有导致认知功能进一步下降。需要进一步研究以帮助了解其中的机制。

{"title":"Childhood maltreatment, cognitive performance, and cognitive decline in middle-aged and older adults with chronic disease: A prospective study","authors":"Ann Xiuli Chicoine , Howard Chertkow , Jean-Claude Tardif , David Busseuil , Bianca D'Antono","doi":"10.1016/j.jpsychores.2024.111965","DOIUrl":"10.1016/j.jpsychores.2024.111965","url":null,"abstract":"<div><h3>Objectives</h3><div>Childhood maltreatment (CM) may increase the risk for cognitive deficits and dementia later in life. However, most research has been cross-sectional in nature, has typically focused on specific types of CM, and rarely examined individual differences. The objectives are to evaluate 1) if CM predicts poorer cognitive performance and greater cognitive decline over a 5-year follow-up in older men and women with coronary artery disease (CAD) or other non-cardiovascular (non-CVD) chronic disease, and whether 2) sex and CAD status influence these relations.</div></div><div><h3>Methods</h3><div>Men and women (<em>N</em> = 1254; 39.6 % women; 65.6 ± 7.0 years old) with CAD or other non-CVD chronic diseases completed the Childhood Trauma Questionnaire Short Form (CTQ-SF). The Montreal Cognitive Assessment (MoCA) was administered twice at 5-year intervals. Main analyses included bivariate correlations, hierarchical analyses and moderation analyses controlling for sociodemographic and health parameters.</div></div><div><h3>Results</h3><div>CM was experienced by 32 % of the sample, while scores suggestive of cognitive deficits were obtained by 32.7 % and 40.2 % at study onset and follow-up, respectively. CM was associated with significantly lower MoCA scores at study onset (b = −0.013, <em>p</em> = 0.020), but not with change in MoCA over time (b = −0.002, <em>p</em> = 0.796). While MoCA scores did differ as a function of sex and CAD status, the latter did not influence the relations between maltreatment and MoCA.</div></div><div><h3>Conclusions</h3><div>CM predicted poorer cognitive functioning among older individuals with chronic diseases but did not play a role in any further cognitive decline over the follow-up period. Further research is needed to help understand the mechanisms implicated.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"187 ","pages":"Article 111965"},"PeriodicalIF":3.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlike other medical conditions, type 2 diabetes is a risk factor for new-onset major depression after COVID-19 与其他疾病不同，2 型糖尿病是 COVID-19 后新发重度抑郁症的风险因素。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-21 DOI: 10.1016/j.jpsychores.2024.111963

Matthieu Gasnier , Anne-Lise Lecoq , Tài Pham , Luc Morin , François Radiguer , Eugénie Gosset-Grainville , Marie Quinque , Wassim Najib Alaoui , Eric Deflesselle , Walid Choucha , Samy Figueiredo , Mohamad Zaidan , Laurent Savale , David Montani , Xavier Monnet , Laurent Becquemont , Emmanuelle Corruble , Romain Colle

Objective

It is unclear whether pre-COVID medical conditions are risk factors for post-COVID major depressive episode (MDE). We aimed to determine which pre-COVID medical conditions are risk factors for post-COVID MDE after a hospitalization for COVID-19.

Methods

We conducted a nested retrospective case-cohort study within a cohort of 650 patients evaluated six months after hospitalization for COVID-19 at Bicêtre hospital, France. Nine medical conditions present before COVID-19 (High blood pressure, obesity, type 2 diabetes, cardiac, respiratory and renal disease, immune deficiency, neoplasia and liver disease) were extracted from medical records. MDE was assessed using the Structured Clinical Interview for DSM-5 Disorders-Clinician Version (SCID-5-CV). Bivariate and multivariable analyses were performed to determine which pre-COVID medical conditions are independent risk factors for post-COVID new-onset MDE.

Results

Patients mean age was 62.8 (15.8), 258 (39.7 %) were women; 301 (46.3 %) had high blood pressure, 205 (32.4 %) had obesity, and 186 (28.6 %) had type 2 diabetes. Thirty-six (5.5 %) patients were diagnosed with a new-onset MDE. In contrast to other medical conditions, type 2 diabetes was significantly associated with new-onset MDE (OR = 2.51 [1.19–5.29]).

Conclusion

Unlike other pre-COVID medical conditions, type 2 diabetes is a risk factor for post-COVID MDE. Patients with type 2 diabetes should be screened for MDE after a hospitalization for COVID-19.

目的：目前尚不清楚COVID前的医疗状况是否是COVID后重度抑郁发作（MDE）的风险因素。我们旨在确定哪些 COVID 前的医疗状况是 COVID-19 住院后重度抑郁发作的风险因素：我们在法国 Bicêtre 医院对 COVID-19 住院 6 个月后进行评估的 650 名患者队列中开展了一项巢式回顾性病例队列研究。研究人员从病历中提取了 COVID-19 前的九种疾病（高血压、肥胖、2 型糖尿病、心脏病、呼吸系统疾病、肾病、免疫缺陷、肿瘤和肝病）。MDE 采用 DSM-5 疾病结构化临床访谈-医师版（SCID-5-CV）进行评估。进行了二元和多元分析，以确定哪些COVID前的疾病是COVID后新发MDE的独立风险因素：患者平均年龄为 62.8（15.8）岁，258（39.7%）人为女性；301（46.3%）人患有高血压，205（32.4%）人患有肥胖症，186（28.6%）人患有 2 型糖尿病。有 36 名患者（5.5%）被诊断为新发 MDE。与其他病症相比，2 型糖尿病与新发 MDE 显著相关（OR = 2.51 [1.19-5.29]）：结论：与COVID前的其他病症不同，2型糖尿病是COVID后MDE的风险因素。2型糖尿病患者在因COVID-19住院后应进行MDE筛查。

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引用次数: 0

Weekend sleep duration, weekday sleep characteristics and the risk of prediabetes and diabetes 周末睡眠时间、平日睡眠特征与糖尿病前期和糖尿病风险。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-18 DOI: 10.1016/j.jpsychores.2024.111959

Tomoyuki Kawada

引用次数: 0

Association between fluctuations in blood cholesterol levels and the risk of suicide death in the general population 血液中胆固醇水平的波动与普通人群自杀死亡风险之间的关系

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-18 DOI: 10.1016/j.jpsychores.2024.111956

Chaiho Jeong , Jin-Hyung Jung , Dae Jong Oh , Kyungdo Han , Mee Kyoung Kim

Objective

Suicide is a pressing global public health issue. While recent studies have explored the association between serum cholesterol levels and suicide risk, the association between cholesterol variability and suicide risk is not well characterized.

Methods

This was a nationwide population-based cohort study using data from the Korean National Health Insurance Service database. A total of 1,983,701 patients with at least three measurements of TC between 2004 and 2009 were included. Participants were followed until death by suicide or the study's end in December 2021. Participants were categorized based on baseline TC or TC variability. TC variability was assessed using coefficient of variation (CV), variability independent of the mean (VIM), and average successive variability (ASV).

Results

Over a median follow-up of 11 years, 5883 (0.3 %) patients died by suicide. Compared to subjects with TC <200 mg/dL, those with TC ≥240 mg/dL had a lower risk of suicide death (hazard ratio [HR]: 0.85, 95 % confidence interval [95 % CI]: 0.78–0.93). In the unadjusted model, the HR for suicide death in the highest quartile (Q4) compared to the lowest quartile (Q1) of TC variability was 1.36 (95 % CI: 1.26–1.46). After adjusting for potential confounders, high variability in TC levels was associated with a higher risk of suicide death (HR 1.27, 95 % CI: 1.18–1.37). When analyzed based on the combination of TC baseline and variability, the highest quartile of TC variability showed a higher rate of suicide death compared to the lowest quartile, regardless of baseline TC level.

Conclusion

High TC variability and low TC levels were associated with an increased risk of suicide.

目的自杀是一个紧迫的全球性公共卫生问题。尽管最近的研究探讨了血清胆固醇水平与自杀风险之间的关系，但胆固醇变异性与自杀风险之间的关系还没有得到很好的描述。方法这是一项基于全国人口的队列研究，使用的数据来自韩国国民健康保险服务数据库。共纳入了 1,983,701 名在 2004 年至 2009 年期间至少测量过三次胆固醇的患者。研究人员对参与者进行了随访，直至其自杀身亡或研究于 2021 年 12 月结束。根据基线 TC 或 TC 变异性对参与者进行分类。采用变异系数（CV）、不依赖于平均值的变异性（VIM）和平均连续变异性（ASV）对TC变异性进行评估。结果在11年的中位随访中，有5883名（0.3%）患者死于自杀。与血清总胆固醇<200毫克/分升的受试者相比，血清总胆固醇≥240毫克/分升的受试者自杀死亡的风险较低（危险比[HR]：0.85，95%置信区间[95% CI]：0.78-0.93）。在未经调整的模型中，与血 TC 变异性最低的四分位数（Q1）相比，血 TC 变异性最高的四分位数（Q4）的自杀死亡风险为 1.36（95 % 置信区间：1.26-1.46）。在对潜在的混杂因素进行调整后，TC 水平的高变异性与自杀死亡的高风险相关（HR 1.27，95 % CI：1.18-1.37）。根据血 TC 基线和变异性组合进行分析时，无论血 TC 基线水平如何，血 TC 变异性最高的四分位数与最低的四分位数相比，自杀死亡率更高。

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引用次数: 0

Dissecting the association between long COVID and depressive symptoms in a nationally representative population from France 在法国具有全国代表性的人群中剖析长 COVID 与抑郁症状之间的关联。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-10-18 DOI: 10.1016/j.jpsychores.2024.111961

Sarah Tebeka , Joël Coste , Tatjana T. Makovski , Caroline Alleaume , Cyrille Delpierre , Anne Gallay , Baptiste Pignon , Clément Gouraud , Charles Ouazana Vedrines , Victor Pitron , Olivier Robineau , Olivier Steichen , Cédric Lemogne

Objective

Depressive symptoms may overlap with those of long COVID. This cross-sectional study aims to compare the prevalence of depressive symptoms among individuals infected with SARS-CoV-2 with versus without long COVID and to explore specific associations with each of the nine core symptoms of major depression.

Methods

Data regarding age, gender, SARS-CoV-2 infections, current symptoms, their date of onset, impact on daily functioning, and consideration of alternative diagnoses were collected through phone interviews between September and December 2022 in a nationally representative sample of adults aged ≥18. Data on chronic health conditions and depressive symptoms (PHQ-9) were collected online in infected participants with or without long COVID, according to the WHO definition of the post-COVID-19 condition.

Results

Among 1247 participants (mean age (SD): 48.3 (14.3) years, 53.3 % of women), 12.8 % had long COVID and 87.2 % experienced SARS-CoV-2 infection at least 3 months prior to the survey without long COVID. Participant with long COVID were four-fold more likely to have a PHQ-9 score ≥ 10 than those without (44.0 % versus 11.1 %). Three symptoms out of nine were independently associated with long COVID: little interest or pleasure (aOR [95 % CI]: 2.01 [1.03–3.92]), feeling tired or having little energy (1.92 [1.10–3.33]), and poor attention/concentration (2.02 [1.03–3.96]).

Conclusion

Clinicians should screen patients with long COVID for major depression but associations with specific depressive symptoms suggest some clinical overlap. Future studies should consider the course of each depressive symptom separately and focus on those less prone to overlap with symptoms of long COVID.

目的抑郁症状可能与长COVID的症状重叠。本横断面研究旨在比较感染 SARS-CoV-2 并伴有和未伴有长 COVID 的人群中抑郁症状的发生率，并探讨与重度抑郁症九种核心症状中每种症状的具体关联：在 2022 年 9 月至 12 月期间，通过电话访问具有全国代表性的年龄≥18 岁的成年人样本，收集了有关年龄、性别、SARS-CoV-2 感染情况、当前症状、发病日期、对日常功能的影响以及是否考虑过其他诊断的数据。根据世界卫生组织对COVID-19后病情的定义，在线收集了有或无长期COVID的感染者的慢性健康状况和抑郁症状（PHQ-9）数据：在 1247 名参与者（平均年龄（SD）：48.3（14.3）岁，53.3% 为女性）中，12.8% 的人有长期 COVID，87.2% 的人在调查前至少 3 个月感染过 SARS-CoV-2，但没有长期 COVID。PHQ-9 评分≥10分的参与者中，患有长COVID的比例是未患有长COVID的比例的四倍（44.0%对11.1%）。在九种症状中，有三种症状与长期COVID独立相关：缺乏兴趣或乐趣（aOR [95 % CI]：2.01 [1.03-3.92]）、感到疲倦或精力不足（1.92 [1.10-3.33]）以及注意力/集中力差（2.02 [1.03-3.96]）：临床医生应筛查长 COVID 患者是否患有重度抑郁症，但与特定抑郁症状的关联表明存在一些临床重叠。未来的研究应分别考虑每种抑郁症状的病程，并重点关注不易与长 COVID 症状重叠的患者。

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引用次数: 0