Journal of Psychosomatic Research最新文献_第9页

Reduced distress tolerance and elevated depression in functional tremor: A comparative cross-sectional observational study of tremor disorders 功能性震颤的痛苦耐受性降低和抑郁升高：震颤障碍的比较横断面观察研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jpsychores.2025.112479

Patrick Sheehan , Yongjia Deng , Holly E. Phelps , Nicholas Jasinski , Kierstan Pyle , Michelle M. Coleman , Danielle Sblendorio , Delanie Talkington , Ann Murray , Adeel A. Memon , Maria C. Moreno-Escobar , Jessica Frey

Background

Patients with Parkinson's Disease (PD) frequently experience depression and anxiety, while those with Essential Tremor (ET) report anxiety and embarrassment related to their tremor. The emotional burden of functional tremor (FT) is less well understood.

Objective

To examine distress tolerance and related psychological symptoms across tremor subtypes.

Methods

Patients with FT (n = 20), ET (n = 21), and PD (n = 20) completed the Distress Tolerance Scale, Beck's Depression Inventory, and Essential Tremor Embarrassment Assessment. Adverse childhood experiences (ACEs), tremor-related disability, and tremor severity were also assessed.

Results

Patients with FT reported significantly higher depression than both PD and ET groups (overall: F(2,54) = 6.85, p = .002; FT vs. PD: p = .005; FT vs. ET: p = .005), and lower distress tolerance than the PD group (F(2,54) = 3.54, p = .036). No significant differences were found between groups in embarrassment, ACEs, nor disability.

Conclusion

This distinct psychological profile in patients with FT highlights the need for integrated biopsychosocial care, and the development of targeted, comprehensive interventions.

Tremor is the most common symptom in movement disorder clinics (Sharma and Pandey, 2016 [1]). Essential Tremor (ET) affects ∼5.8 % of people over 65 (Louis and McCreary, 2021 [2]), while Parkinson's Disease (PD) affects ∼1 % of people over 60 (Tysnes and Storstein, 2017 [3]). Functional tremors (FT), the most common functional movement disorder (FMD), comprise 55 % of FMD diagnoses (Bhatia and Schneider, 2007 [4]).

帕金森氏病（PD）患者经常经历抑郁和焦虑，而原发性震颤（ET）患者则报告与震颤相关的焦虑和尴尬。功能性震颤（FT）的情绪负担尚不清楚。目的探讨不同震颤亚型患者的痛苦耐受性及相关心理症状。方法FT （n = 20）、ET （n = 21）、PD （n = 20）患者分别完成痛苦耐受量表、贝克抑郁量表和特发性震颤困窘评定。不良童年经历（ace）、震颤相关残疾和震颤严重程度也被评估。结果FT患者的抑郁程度明显高于PD组和ET组(总体：F(2,54) = 6.85, p = 0.002；FT vs. PD: p = 0.005；FT组与ET组：p = 0.005)，且痛苦耐受力低于PD组（F(2,54) = 3.54, p = 0.036）。在尴尬、ace和残疾方面，两组之间没有发现显著差异。结论：FT患者的这种独特的心理特征强调了综合生物心理社会护理的必要性，以及有针对性的综合干预措施的发展。震颤是运动障碍诊所中最常见的症状（Sharma and Pandey, 2016[1]）。特发性震颤（ET）影响约5.8%的65岁以上人群（Louis and McCreary, 2021[3]），而帕金森病（PD）影响约1%的60岁以上人群（Tysnes and Storstein, 2017[3]）。功能性震颤（FT）是最常见的功能性运动障碍（FMD），占FMD诊断的55% （Bhatia和Schneider， 2007[4]）。

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引用次数: 0

Non-pharmacological palliative interventions for cancer-related pain and fatigue: A network meta-analysis 癌症相关疼痛和疲劳的非药物姑息性干预：网络荟萃分析。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.jpsychores.2025.112501

Yan Adi Wibawa , Tsai-Wei Huang , Yan Wisnu Prajoko , Made Satya Nugraha Gautama , Sri Setyowati , Enggar Purnaningsih , Sri Indah Ekowati , Endang Fatmawati , Indriyani , Nur Aini , Fitria Endah Janitra

引用次数: 0

Self-efficacy mediates social support and self-management behaviors in kidney transplant recipients: A systematic review and meta-analytic structural equation modeling analysis 自我效能感对肾移植受者社会支持和自我管理行为的影响：一项系统综述和荟萃分析结构方程模型分析

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jpsychores.2025.112470

Jiaxin Fang , Liu Han , Xiaohong Lin , Keke Lin , Xiangru Li , Yingtian Jia , Xinran Yang , Hongxia Liu , Rongmei Zhang

Background

Self-management among kidney transplant recipients (KTRs) is crucial for preventing postoperative complications and improving health outcomes. However, challenges such as a lack of physical activity and the frequent consumption of high-calorie foods persist. Therefore, targeted interventions for enhancing post-transplant self-management behaviors are essential. Currently, scientific evidence on effective strategies to improve self-management among KTRs is lacking. Enhancing social support and promoting self-efficacy may be significant approaches.

Design and methods

This study employs a meta-analytic structural equation modeling (MASEM) approach to examine the mediating role of self-efficacy in the relationship between social support and self-management behaviors in KTRs. A comprehensive search was conducted across multiple databases, including PubMed, Embase, APA PsycInfo, Cochrane Library, CINAHL, Web of Science, ERIC, Springer, CNKI, VIP, and Wanfang, from the inception of each database until August 9, 2024. Statistical analyses were performed using Comprehensive Meta-Analysis software, Mplus for Mac, and R Studio for Mac.

Results

A total of 1990 titles and abstracts were screened in this study, resulting in the inclusion of 19 studies. The MASEM was constructed using a two-stage structural equation modeling approach. The analysis revealed that self-efficacy partially mediated the relationship between social support and self-management behaviors (direct effect: 0.140; indirect effect: 0.299; 95 % CI: 0.268, 0.331).

Conclusions

This study highlights the importance of clinical interventions aimed at enhancing social support and self-efficacy to improve self-management behaviors in KTRs.

Registration

https://doi.org/10.17605/OSF.IO/MXBZY(https://osf.io/).

背景肾移植受者的自我管理对于预防术后并发症和改善健康结果至关重要。然而，缺乏体育活动和频繁食用高热量食物等挑战依然存在。因此，加强移植后自我管理行为的针对性干预至关重要。目前，缺乏有效的策略来提高ktr自我管理的科学证据。加强社会支持和提高自我效能感可能是重要的途径。设计与方法本研究采用元分析结构方程模型（MASEM）方法，探讨自我效能感在社会支持与自我管理行为之间的中介作用。我们对PubMed、Embase、APA PsycInfo、Cochrane Library、CINAHL、Web of Science、ERIC、施普林格、CNKI、VIP、万方等多个数据库进行了全面检索，检索时间从每个数据库建立到2024年8月9日。采用综合meta分析软件Mplus for Mac和R Studio for Mac进行统计分析。结果本研究共筛选了1990篇论文和摘要，纳入了19篇研究。MASEM采用两阶段结构方程建模方法构建。分析发现，自我效能感在社会支持与自我管理行为的关系中起部分中介作用（直接效应：0.140；间接效应：0.299;95% CI: 0.268, 0.331）。结论加强社会支持和自我效能感的临床干预对改善ktrs患者的自我管理行为具有重要意义[j] . registrationhttp://doi.org/10.17605/OSF.IO/MXBZY(https://osf.io/。

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引用次数: 0

Corrigendum to ‘Machine learning–based prediction of delirium in older patients with chronic kidney disease requiring intensive care: A hospital-based retrospective cohort study’ [Journal of Psychosomatic Research, 200 (2026), article PSR_112454] “基于机器学习预测需要重症监护的老年慢性肾病患者谵妄：一项基于医院的回顾性队列研究”的更正[Journal of Psychosomatic Research， 200(2026)，文章PSR_112454]。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-08 DOI: 10.1016/j.jpsychores.2025.112494

Chia-Rung Wu , Yung-Chun Chang , Victoria Traynor , Shu-Tai Shen Hsiao , Shu-Liu Guo , Shu-Chuan Lin , Sen-Kuang Hou , Hsiao-Yean Chiu

引用次数: 0

A longitudinal latent class analysis of health-related quality of life post pelvic fractures; the BIOS cohort study 骨盆骨折后健康相关生活质量的纵向潜类分析BIOS队列研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.jpsychores.2025.112504

Maartje L.V. Kusters , Nina Kupper , Lars Brouwers , Mariska A.C. de Jongh

Background

The objective of this study was to identify latent profiles in the HRQoL recovery of patients with pelvic fractures and examine demographic, psychological, and medical determinants.

Methods

184 patients (M_age = 58.3 ± 16.9, 59 % male) from the BIOS study were included. HRQoL was assessed six times across two years. At 1-week post-injury, additional pre-injury HRQoL (EQ-5D-3L), psychological (HADS, IES), and functional (MPS, MAHS) measures were assessed. A 3-step repeated measures latent class analysis (RMLCA) identified latent profiles in HRQoL and examined their correlates.

Results

Four similar recovery profiles for the EQ-5D domains of VAS, mobility, and usual activities were identified: low/poor, intermediate/partial, high/full, and prominent improvement/fast & full recovery. For the EQ-5D domains of pain/discomfort, self-care, and anxiety/depression, three similar profiles were identified: poor recovery, partial recovery/intermediate problems, and full recovery/ no pain. Higher emotional distress, comorbidities, and complications were associated with the low VAS profile. Older age, pelvic ring fracture, pelvic surgery, higher ISS, lower emotional distress, and higher pre-injury HRQoL levels were associated with the prominent improvement VAS profile. Better physical functioning was associated with the intermediate and high VAS profiles.

Conclusions

Results unveiled person-level heterogeneity evidenced by the four latent recovery trajectories of HRQoL following pelvic fracture and their distinct associated covariates, among which psychological functioning, which significantly contributed to HRQoL recovery. Future research should focus on the development of adequate screening tools facilitating decision-making applications which in turn can optimize personalized treatment programs. The current findings offer valuable insights to aid in this developmental process.

本研究的目的是确定骨盆骨折患者HRQoL恢复的潜在特征，并检查人口统计学、心理和医学决定因素。方法纳入184例BIOS患者（年龄≥58.3±16.9，男性59%）。HRQoL在两年内评估了六次。在损伤后1周，评估其他损伤前HRQoL （EQ-5D-3L）、心理（HADS、IES）和功能（MPS、MAHS）指标。采用3步重复测量潜类分析（RMLCA）确定HRQoL的潜类特征，并检验其相关性。结果在VAS的EQ-5D域、可动性和日常活动方面有4个相似的恢复特征：低/差、中/部分、高/完全和显著改善/快速和完全恢复。对于疼痛/不适、自我照顾和焦虑/抑郁的EQ-5D领域，确定了三种相似的特征：恢复不良、部分恢复/中度问题和完全恢复/无疼痛。较高的情绪困扰、合并症和并发症与较低的VAS评分有关。年龄较大、骨盆环骨折、骨盆手术、较高的ISS、较低的情绪困扰和较高的损伤前HRQoL水平与VAS评分显著改善相关。较好的身体功能与中高VAS评分相关。结论骨盆骨折后HRQoL的四个潜在恢复轨迹及其不同的相关协变量显示了个体水平的异质性，其中心理功能对HRQoL的恢复有显著影响。未来的研究应侧重于开发适当的筛查工具，以促进决策应用，从而优化个性化的治疗方案。目前的研究结果为这一发展过程提供了有价值的见解。

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引用次数: 0

Single-arm longitudinal study to assess changes in insula functional connectivity following a mobile-based lifestyle intervention in adults with metabolic abnormalities 单臂纵向研究评估代谢异常成人在移动生活方式干预后脑岛功能连通性的变化。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-14 DOI: 10.1016/j.jpsychores.2025.112498

Deokjong Lee , Kyung Mee Park , Jihye Kim , Sin Young Ko , Byeonghee Lee , Chae Jung Park , Kyoung Min Kim , Jin Young Park

Backgrounds

Mobile-based lifestyle intervention has been widely used to improve behavior for obesity and overweight. This study targeting adults with metabolic abnormalities aims to identify neural correlates related to weight loss due to mobile-based lifestyle intervention.

Methods

We conducted 8 weeks of mobile-based lifestyle intervention for 37 adults with metabolic abnormalities, including overweight. Participants underwent physical measurements, blood tests, psychometric questionnaires, and resting-state functional magnetic resonance imaging (fMRI) scans before and after the mobile-based intervention. For the resting-state fMRI, brain regions that showed changes in functional connectivity (FC) before and after mobile-based intervention were explored. Seed-based FC analysis was performed focusing on the subregions of the insular cortex.

Results

Participants significantly reduced body mass index (BMI) after mobile-based intervention. The degree of BMI reduction was significantly correlated with compliance with the intervention. In resting fMRI, FC of the posterior insula with the bilateral inferior parietal lobule and the left ventrolateral prefrontal cortex were enhanced after mobile-based intervention. The increase in FC between the posterior insula and the inferior posterior lobule showed a significant correlation with the decrease in binge eating scale scores.

Conclusion

The mobile-based lifestyle intervention significantly reduced weight and alleviated binge eating in adults with metabolic abnormalities. FC enhancement between the posterior insula and the frontoparietal regions was also observed after mobile-based lifestyle intervention. The relationship between these FC changes and strengthening weight control through mobile-based lifestyle intervention should be investigated through future research.

背景：基于手机的生活方式干预已被广泛用于改善肥胖和超重的行为。这项针对成人代谢异常的研究旨在确定基于移动的生活方式干预与体重减轻相关的神经相关性。方法：我们对37名代谢异常（包括超重）的成年人进行了8周的基于移动的生活方式干预。参与者在移动干预前后接受了身体测量、血液测试、心理测量问卷和静息状态功能磁共振成像（fMRI）扫描。对于静息状态fMRI，研究人员探索了在基于移动的干预前后显示功能连接（FC）变化的大脑区域。基于种子的FC分析集中在岛叶皮层的亚区。结果：参与者在移动干预后显著降低了身体质量指数（BMI）。BMI降低程度与干预依从性显著相关。静息fMRI显示，运动干预后，脑岛后部与双侧下顶叶和左腹外侧前额叶皮层的FC增强。后岛叶和下后小叶之间FC的增加与暴食量表得分的下降有显著相关。结论：以移动为基础的生活方式干预可显著减轻代谢异常成人的体重和暴饮暴食。在以移动为基础的生活方式干预后，也观察到脑岛后部和额顶叶区域之间的FC增强。这些FC变化与通过基于移动的生活方式干预加强体重控制之间的关系应该通过未来的研究来调查。

{"title":"Single-arm longitudinal study to assess changes in insula functional connectivity following a mobile-based lifestyle intervention in adults with metabolic abnormalities","authors":"Deokjong Lee , Kyung Mee Park , Jihye Kim , Sin Young Ko , Byeonghee Lee , Chae Jung Park , Kyoung Min Kim , Jin Young Park","doi":"10.1016/j.jpsychores.2025.112498","DOIUrl":"10.1016/j.jpsychores.2025.112498","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Mobile-based lifestyle intervention has been widely used to improve behavior for obesity and overweight. This study targeting adults with metabolic abnormalities aims to identify neural correlates related to weight loss due to mobile-based lifestyle intervention.</div></div><div><h3>Methods</h3><div>We conducted 8 weeks of mobile-based lifestyle intervention for 37 adults with metabolic abnormalities, including overweight. Participants underwent physical measurements, blood tests, psychometric questionnaires, and resting-state functional magnetic resonance imaging (fMRI) scans before and after the mobile-based intervention. For the resting-state fMRI, brain regions that showed changes in functional connectivity (FC) before and after mobile-based intervention were explored. Seed-based FC analysis was performed focusing on the subregions of the insular cortex.</div></div><div><h3>Results</h3><div>Participants significantly reduced body mass index (BMI) after mobile-based intervention. The degree of BMI reduction was significantly correlated with compliance with the intervention. In resting fMRI, FC of the posterior insula with the bilateral inferior parietal lobule and the left ventrolateral prefrontal cortex were enhanced after mobile-based intervention. The increase in FC between the posterior insula and the inferior posterior lobule showed a significant correlation with the decrease in binge eating scale scores.</div></div><div><h3>Conclusion</h3><div>The mobile-based lifestyle intervention significantly reduced weight and alleviated binge eating in adults with metabolic abnormalities. FC enhancement between the posterior insula and the frontoparietal regions was also observed after mobile-based lifestyle intervention. The relationship between these FC changes and strengthening weight control through mobile-based lifestyle intervention should be investigated through future research.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"201 ","pages":"Article 112498"},"PeriodicalIF":3.3,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spirituality, collectivism, and psychosomatic health: A new pathway for culturally responsive mental health care in Southeast Asia 灵性、集体主义和心身健康：东南亚文化响应性精神卫生保健的新途径。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-11-29 DOI: 10.1016/j.jpsychores.2025.112481

Ashari Mahfud , Anisatul Latifah , Citra Abriani Maharani , Shinta Mayasari , Muslikah , Marlin Sianturi

引用次数: 0

Factors influencing excessive daytime sleepiness in obstructive sleep apnea: A retrospective cohort analysis integrating psychological assessment with polysomnography 影响阻塞性睡眠呼吸暂停患者日间过度嗜睡的因素：一项综合心理评估和多导睡眠图的回顾性队列分析。

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1016/j.jpsychores.2025.112502

Tuzhi Wang, Guoliang Peng, Kaiqi Huang, Hongyao Li, Yushan Chen, Xiaotao Zhang, Jiyang Pan

Objective

This study aimed to systematically evaluate psychological and polysomnographic parameters to analyze factors influencing excessive daytime sleepiness (EDS) in patients with obstructive sleep apnea (OSA).

Methods

We conducted a retrospective study of 318 adult OSA patients from a tertiary hospital sleep center. Participants underwent overnight polysomnography and completed questionnaires including the Epworth Sleepiness Scale (ESS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Mood Disorder Questionnaire (MDQ). Statistical analyses involved univariate and multivariable logistic regression, with dose-response relationships assessed using restricted cubic splines.

Results

Among 318 OSA patients, 95 (29.9 %) had EDS (ESS >10). The EDS group showed significantly higher PHQ-9, GAD-7, and MDQ scores (all p < 0.05). Polysomnography revealed that EDS patients exhibited longer total sleep time, shorter wake after sleep onset, higher apnea-hypopnea index (AHI), elevated AHI during rapid eye movement sleep, and reduced lowest oxygen saturation. After adjusting for confounders, multivariable analysis identified PHQ-9 scores (OR = 1.12, 95 %CI:1.06–1.18), MDQ scores (OR = 1.16, 95 %CI:1.06–1.27), and respiratory arousal index (OR = 1.03, 95 %CI:1.01–1.05) as independent risk factors for EDS, all demonstrating significant positive linear dose-response relationships.

Conclusion

Our findings indicate that depressive symptoms, subclinical affective instability, and respiratory arousals are independently associated with EDS in OSA patients, with clear dose-response relationships. These results suggest that a multifactorial framework encompassing both psychological and physiological domains may be a valuable direction for understanding EDS, and warrant future investigation into the clinical value of integrated assessments.

目的：本研究旨在系统评价阻塞性睡眠呼吸暂停（OSA）患者的心理及多导睡眠图参数，分析影响患者日间过度嗜睡（EDS）的因素。方法：对某三级医院睡眠中心318例OSA患者进行回顾性研究。参与者接受了夜间多导睡眠检查，并完成了包括Epworth嗜睡量表（ESS）、患者健康问卷-9 （PHQ-9）、广泛性焦虑障碍问卷-7 （GAD-7）和情绪障碍问卷（MDQ）在内的调查问卷。统计分析包括单变量和多变量逻辑回归，使用限制三次样条评估剂量-反应关系。结果：318例OSA患者中，95例（29.9%）发生EDS （ESS 2010）。结论：我们的研究结果表明，抑郁症状、亚临床情感不稳定和呼吸觉醒与OSA患者的EDS独立相关，且存在明显的剂量-反应关系。这些结果表明，一个包括心理和生理领域的多因素框架可能是理解EDS的一个有价值的方向，并保证未来对综合评估的临床价值进行研究。

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引用次数: 0

Personality traits as predictors of self-care agency in women with gynecological cancers: Cross-sectional study 人格特质作为妇科癌症患者自我照顾能力的预测因子：横断面研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.jpsychores.2025.112503

Huri Çolu , Elif Uludağ

Background

Gynecological cancers present a dual burden of physiological and psychosocial distress. Self-care agency defined as an individual's capacity to initiate and maintain health-related behaviors is critical for optimizing well-being in cancer patients. While psychological factors, particularly personality traits, are known to influence self-care in chronic illnesses, their role in gynecological oncology remains underexplored. This study aimed to determine whether personality traits predict self-care agency among women with gynecological cancers.

Methods

A descriptive, cross-sectional design was employed with 200 women recruited via convenience sampling. Data were collected using a demographic form, the Cervantes Personality Scale, and the Exercise of Self-Care Agency Scale. Simple linear regression analyses examined the predictive value of personality subscales on self-care agency.

Results

Personality traits were found to be significant predictors of self-care agency. Extroversion, emotional stability, and consistency explained 37.5 %, 20.1 %, and 30.4 % of the variance in self-care agency, respectively (p < 0.05). Women with higher levels of these traits demonstrated greater self-care capacity, while introversion, neuroticism, and inconsistency were linked to reduced self-care agency.

Conclusions

This study highlights the significant role of personality traits in influencing self-care agency in this population. Tailoring supportive care to address individual personality characteristics may improve self-management and overall treatment outcomes. Incorporating psychosocial assessments into routine care and developing targeted interventions could enhance quality of life. Future research should focus on intervention studies to validate these approaches and optimize personalized care strategies in gynecological oncology.

妇科癌症呈现出生理和社会心理困扰的双重负担。自我保健机构被定义为个人发起和维持与健康有关的行为的能力，对优化癌症患者的福祉至关重要。虽然心理因素，特别是人格特征，已知会影响慢性疾病患者的自我护理，但它们在妇科肿瘤中的作用仍未得到充分探讨。本研究旨在确定人格特征是否能预测妇科癌症患者的自我照顾能力。方法采用描述性、横断面设计，采用方便抽样方法对200名妇女进行调查。数据收集使用人口统计形式，塞万提斯人格量表和自我照顾代理量表的行使。简单线性回归分析了人格分量表对自我照顾能动性的预测价值。结果人格特质是自我照顾能动性的显著预测因子。外向性、情绪稳定性和一致性分别解释了37.5%、20.1%和30.4%的自我照顾能力方差（p < 0.05）。这些特征水平较高的女性表现出更强的自我照顾能力，而内向、神经质和不一致则与自我照顾能力下降有关。结论本研究强调了人格特质对该人群自我照顾能力的重要影响。针对个体个性特征定制支持性护理可以改善自我管理和整体治疗结果。将心理社会评估纳入日常护理并制定有针对性的干预措施可以提高生活质量。未来的研究应侧重于干预研究，以验证这些方法并优化妇科肿瘤的个性化护理策略。

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引用次数: 0

Frequency and correlates of non-adherence in a large sample of adult patients after kidney transplantation: A cross-sectional KTx360° substudy 肾移植后大样本成人患者不依从发生率及其相关因素：一项横断面KTx360°亚研究

IF 3.3 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2026-02-01 Epub Date: 2025-11-25 DOI: 10.1016/j.jpsychores.2025.112474

Mariel Nöhre , Felix Klewitz , Maximilian Bauer-Hohmann , Eva Kyaw Tha Tun , Marietta Lieb , Yesim Erim , Uwe Tegtbur , Lena Schiffer , Lars Pape , Mario Schiffer , Martina de Zwaan

Objective

Non-adherence to immunosuppressive medication (ISM) is a common and preventable cause of graft loss after kidney transplantation (KTx). Adherence is a multifaceted construct influenced by various factors. Despite frequent reports linking non-adherence with multiple variables, results often seem contradictory. The lack of patient registers in Germany to encompass psychosocial aspects limits data to smaller, selective studies. The aim was to evaluate the frequency and correlates of non-adherence in a large sample of adult KTx patients.

Methods

This cross-sectional substudy was embedded within the structured follow-up program KTx360°. It took place at the transplant centers of Hannover Medical School, Hann. Münden and Erlangen in Germany between May 2017 and October 2020. 838 adult KTx patients participated in this substudy. Adherence was assessed using the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) alongside other sociodemographic, psychosocial, and medical variables.

Results

Participants had an average age of 52.3 years (SD = 13.5), with 58.7 % male. According to the BAASIS interview, 22.1 % reported non-adherence, mainly due to timing (13.0 %) and taking (11.7 %) non-adherence, with only 0.5 % ceasing at least one ISM. Factors linked to non-adherence in regression analysis included younger age, male gender, longer post-transplant time, and perceived medication overuse. The effect sizes were small. The informative value is limited by the design and the sample size.

Conclusion

In our cross-sectional analysis, nearly a quarter of the participants reported suboptimal adherence, mainly associated with primarily non-modifiable risk factors. Routine adherence assessments and targeted interventions are essential to improving long-term outcomes.

目的：免疫抑制药物不依从性（ISM）是肾移植术后移植物丧失的一个常见且可预防的原因。依从性是一个受多种因素影响的多方面结构。尽管经常有报告将不遵医嘱与多个变量联系起来，但结果似乎往往是相互矛盾的。德国缺乏包括心理社会方面的患者登记，限制了数据规模较小的选择性研究。目的是评估大量成年KTx患者不依从性的频率和相关因素。方法本横断面亚研究纳入结构化随访计划KTx360°。实验在汉诺威医学院的移植中心进行。2017年5月至2020年10月期间在德国的梅恩登和埃尔兰根。838名成年KTx患者参与了本亚研究。使用巴塞尔免疫抑制药物依从性评估量表（basasis）以及其他社会人口统计学、社会心理和医学变量来评估依从性。结果参与者平均年龄52.3岁（SD = 13.5），男性占58.7%。根据basasis的访谈，22.1%的患者报告未依从性，主要是由于时间（13.0%）和服用（11.7%）未依从性，只有0.5%的患者至少停止了一次ISM。在回归分析中，与不依从性相关的因素包括年龄较小、男性、移植后时间较长和感知到的药物过度使用。效应量很小。信息价值受到设计和样本量的限制。在我们的横断面分析中，近四分之一的参与者报告了不理想的依从性，主要与主要不可改变的风险因素有关。常规依从性评估和有针对性的干预措施对于改善长期结果至关重要。

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引用次数: 0