Journal of Psychosomatic Research最新文献_第9页

Effects of app-based relaxation techniques on perceived momentary relaxation: Observational data analysis in people with cancer 基于应用程序的放松技巧对瞬间放松感知的影响：癌症患者的观察数据分析。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-23 DOI: 10.1016/j.jpsychores.2024.111864

Objective

To examine the effects of six relaxation techniques on perceived momentary relaxation and a possible association of relaxation effects with time and practice experience in people with cancer.

Methods

We used data from participants with cancer in a larger study practicing app-based relaxation techniques over 10 weeks, assessed momentary relaxation before and after every third relaxation practice, and analyzed momentary relaxation changes with a linear mixed-effects model.

Results

The sample included 611 before-after observations from 91 participants (70 females (76.9%)) with a mean age of 55.43 years (SD 10.88). We found moderate evidence for variations in momentary relaxation changes across different techniques (P = .026), with short meditation, mindfulness meditation, guided imagery, and progressive muscle relaxation more frequently observed and leading to more relaxation than body scan and walking meditation. Furthermore, we found moderate evidence for increasing momentary relaxation changes over time (P = .046), but no evidence for an association between momentary relaxation and the number of previous observations (proxy for practice experience; P = .47).

Conclusion

We compared six app-based relaxation techniques in a real-life setting of people with cancer. The observed variations in perceived momentary relaxation appear to correspond with the popularity of the techniques used: The most popular relaxation techniques were the most effective and the least popular were the least effective. The effects increased over time, likely caused by dropout of individuals who gained no immediate benefit. Our findings open an interesting avenue for future research to better understand which relaxation techniques work best for whom in which situations.

Trial Registration

DRKS00027546; https://drks.de/search/en/trial/DRKS00027546

目的研究六种放松技巧对癌症患者瞬间放松感知的影响，以及放松效果与时间和练习经验之间可能存在的关联：我们使用了一项大型研究中癌症患者在 10 周内练习基于应用程序的放松技巧的数据，在每三次放松练习前后对瞬间放松进行了评估，并使用线性混合效应模型分析了瞬间放松的变化：样本包括 91 名参与者（70 名女性，占 76.9%）的 611 个前后观察结果，平均年龄为 55.43 岁（标准差为 10.88）。我们发现有中等程度的证据表明，不同技巧的瞬间放松变化存在差异（P = .026），与身体扫描和步行冥想相比，短时冥想、正念冥想、引导想象和渐进式肌肉放松的观察频率更高，带来的放松也更多。此外，我们还发现了随着时间推移瞬间放松变化增加的中等程度证据（P = .046），但没有证据表明瞬间放松与之前观察次数（代表练习经验；P = .47）之间存在关联：我们在癌症患者的真实生活环境中比较了六种基于应用程序的放松技巧。观察到的瞬间放松感的变化似乎与所使用技巧的流行程度相符：最受欢迎的放松技巧效果最好，而最不受欢迎的技巧效果最差。随着时间的推移，效果会逐渐增强，这可能是由于没有立即获益的人退出了研究。我们的研究结果为今后的研究开辟了一条有趣的途径，以更好地了解哪些放松技巧在哪些情况下对哪些人最有效：DRKS00027546; https://drks.de/search/en/trial/DRKS00027546.

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引用次数: 0

Cultural resonance and medical practice: Heart rate variability test in Taiwanese psychiatry clinics 文化共鸣与医疗实践：台湾精神病诊所的心率变异性测试

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-17 DOI: 10.1016/j.jpsychores.2024.111860

引用次数: 0

Which patients are at risk of developing symptom diagnoses that persist for more than a year in primary care? Development and external validation of a prediction model 哪些患者有可能在初级保健中出现持续一年以上的症状诊断？预测模型的开发和外部验证

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-15 DOI: 10.1016/j.jpsychores.2024.111859

Objectives

To train, test and externally validate a prediction model that supports General Practitioners (GPs) in early identification of patients at risk of developing symptom diagnoses that persist for more than a year.

Methods

We retrospectively collected and selected all patients having episodes of symptom diagnoses during the period 2008 and 2021 from the Family Medicine Network (FaMe-Net) database. From this group, we identified symptom diagnoses that last for less than a year and symptom diagnoses that persist for more than a year. Multivariable logistic regression analysis using a backward selection was used to assess which factors were most predictive for developing symptom diagnoses that persist for more than a year. Performance of the model was assessed using calibration and discrimination (AUC) measures. External validation was tested using data between 2018 and 2022 from AHON-registry, a primary care electronic health records data registry including 73 general practices from the north and east regions of the Netherlands and about 460, 795 patients.

Results

From the included 47,870 patients with a symptom diagnosis in the FaMe-Net registry, 12,481 (26.1%) had a symptom diagnosis that persisted for more than a year. Older age (≥ 75 years: OR = 1.30, 95% CI [1.19, 1.42]), having more previous symptom diagnoses (≥ 3: 1.11, [1.05, 1.17]) and more contacts with the GP over the last 2 years (≥ 10 contacts: 5.32, [4.80, 5.89]) were predictive of symptom diagnoses that persist for more than a year with a marginally acceptable discrimination (AUC 0.70, 95% CI [0.69–0.70]). The external validation showed poor performance with an AUC of 0.64 ([0.63–0.64]).

Conclusion

A clinical prediction model based on age, number of previous symptom diagnoses and contacts might help the GP to early identify patients developing symptom diagnoses that persist for more than a year. However, the performance of the original model is limited. Hence, the model is not yet ready for a large-scale implementation.

方法我们从家庭医学网络（FaMe-Net）数据库中回顾性地收集并选择了 2008 年至 2021 年期间所有出现症状诊断的患者。我们从中找出了持续时间少于一年的症状诊断和持续时间超过一年的症状诊断。我们使用反向选择的多变量逻辑回归分析来评估哪些因素对持续一年以上的症状诊断最具预测性。模型的性能通过校准和区分度（AUC）进行评估。使用AHON-登记处2018年至2022年的数据进行了外部验证，该登记处是一个初级保健电子健康记录数据登记处，包括荷兰北部和东部地区的73家全科诊所和约460 795名患者。结果在FaMe-Net登记处纳入的47870名有症状诊断的患者中，有12481人（26.1%）的症状诊断持续一年以上。年龄较大（≥ 75 岁：OR = 1.30，95% CI [1.19，1.42]）、既往症状诊断次数较多（≥ 3 次：1.11，[1.05，1.17]）以及过去 2 年中与全科医生接触次数较多（≥ 10 次：5.32，[4.80，5.89]）均可预测持续一年以上的症状诊断，其区分度略可接受（AUC 0.70，95% CI [0.69-0.70]）。结论基于年龄、既往症状诊断次数和接触次数的临床预测模型可帮助全科医生及早发现症状诊断持续一年以上的患者。然而，原始模型的性能有限。因此，该模型尚未准备好大规模实施。

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引用次数: 0

The weight of weights: Causal impact of overweight on major depressive disorder and its disparate association with suicide attempts in over 450,000 individuals of European ancestry (AM-SRNMA 003) 体重的重量：超重对重度抑郁障碍的因果影响及其与超过 45 万欧洲血统的自杀企图的不同关联（AM-SRNMA 003）

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-14 DOI: 10.1016/j.jpsychores.2024.111858

Aim

Some studies and societal discussions have suggested a potential link between overweight and a higher risk of mental disorders and suicidal ideation. However, the causal relationships between these factors remain unclear. This study aims to assess the bidirectional causal associations between overweight and mental disorders, including suicidal attempts.

Method

We conducted a Two-Sample Mendelian Randomization study utilizing data from over 450,000 individuals of European ancestry sourced from a comprehensive Genome-Wide Association Study database. We chose single-nucleotide polymorphisms as instrumental variables.

Results

Our analyses consistently supported a unidirectional causal association of overweight with the increased risk of major depressive disorder (MDD, β = 0.152, se = 0.069, P = 0.027), bipolar affective disorders (BD, β = 0.197, se = 0.092, P = 0.033), and attention-deficit / hyperactivity disorder (ADHD, β = 0.308, se = 0.080, P = 1.366 × 10⁻⁴). We observed no significant causal relationships for the exposure of overweight to anxiety disorder (AD), manic episode (MA), panic disorder (PD), schizophrenia (SZ), substance use disorder (SUD), autism spectrum disorder (ASD), ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

Conclusion

This study has provided evidence for the causal relationship between overweight and MDD, BD, ADHD, with no observed relationship between overweight and AD, MA, PD, SZ, SUD, ASD, ever attempted suicide, recent thoughts of suicide or self-harm, and suicide or other intentional self-harm events.

目的一些研究和社会讨论表明，超重与较高的精神障碍和自杀意念风险之间存在潜在联系。然而，这些因素之间的因果关系仍不明确。本研究旨在评估超重与精神障碍（包括自杀企图）之间的双向因果关系。方法我们利用来自全基因组关联研究综合数据库的超过 45 万名欧洲血统个体的数据，开展了一项双样本孟德尔随机研究。结果我们的分析一致支持超重与重度抑郁障碍（MDD，β = 0.152，se = 0.069，P = 0.027）、双相情感障碍（BD，β = 0.197，se = 0.092，P = 0.033）和注意缺陷/多动障碍（ADHD，β = 0.308，se = 0.080，P = 1.366 × 10-4）的单向因果关系。我们观察到，超重与焦虑症（AD）、躁狂症（MA）、恐慌症（PD）、精神分裂症（SZ）、药物使用障碍（SUD）、自闭症谱系障碍（ASD）、曾经自杀未遂、最近有自杀或自残念头以及自杀或其他故意自残事件之间没有明显的因果关系。结论本研究为超重与 MDD、BD、ADHD 之间的因果关系提供了证据，但未观察到超重与 AD、MA、PD、SZ、SUD、ASD、曾试图自杀、最近有自杀或自残念头以及自杀或其他故意自残事件之间存在关系。

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引用次数: 0

Genetic causal relationship between placental weight and autism spectrum disorder: A two-sample Mendelian randomization study 胎盘重量与自闭症谱系障碍之间的遗传因果关系：双样本孟德尔随机研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-06 DOI: 10.1016/j.jpsychores.2024.111857

Zhao Liu

Object

Previous research has suggested an association between placental tissue abnormalities and the diagnosis of autism spectrum disorder. This study aims to explore the causal relationship between placental weight and autism spectrum disorder.

Methods

This study employed Mendelian randomization analysis to investigate the potential causal relationship between placental weight and autism spectrum disorder. The study design involved two sample populations, with data for the exposed population sourced from previous studies focusing on PW, and data for the outcome population obtained from the Integrative Psychiatric Research and the Psychiatric Genomics Consortium study. To ensure the robustness of the results, three sensitivity analyses were performed, including heterogeneity testing, pleiotropy testing, and a leave-one-out analysis. The inverse variance weighted method served as the gold standard for the Mendelian randomization analysis.

Results

The results of the first analysis revealed a significant correlation between an increase in placental weight and an elevated risk of autism spectrum disorder (p = 0.02). Sensitivity analysis detected heterogeneity and outliers. After removing two outlier SNPs in the second round of analysis, the results still supported a genetic causal relationship between placental weight and autism spectrum disorder (p = 0.01). The second-round sensitivity analysis did not reveal any heterogeneity or outliers.

Conclusion

Our study provides compelling evidence supporting a causal relationship between elevated placental weight and increased risk of autism spectrum disorder. These findings underscore the significance of placental development in the etiology of autism spectrum disorder and propose a potential early predictive indicator for autism spectrum disorder.

研究目的以往的研究表明，胎盘组织异常与自闭症谱系障碍诊断之间存在关联。本研究旨在探讨胎盘重量与自闭症谱系障碍之间的因果关系：本研究采用孟德尔随机分析法调查胎盘重量与自闭症谱系障碍之间的潜在因果关系。研究设计涉及两个样本人群，暴露人群的数据来源于以往以PW为重点的研究，而结果人群的数据则来源于综合精神病学研究和精神病学基因组学联合会的研究。为确保研究结果的稳健性，研究人员进行了三项敏感性分析，包括异质性检验、多效性检验和剔除分析。反方差加权法作为孟德尔随机分析的金标准：第一项分析结果显示，胎盘重量增加与自闭症谱系障碍风险升高之间存在显著相关性（p = 0.02）。敏感性分析发现了异质性和异常值。在第二轮分析中剔除两个异常 SNP 后，结果仍然支持胎盘重量与自闭症谱系障碍之间存在遗传因果关系（p = 0.01）。第二轮敏感性分析未发现任何异质性或异常值：我们的研究提供了令人信服的证据，支持胎盘重量升高与自闭症谱系障碍风险增加之间存在因果关系。这些发现强调了胎盘发育在自闭症谱系障碍病因学中的重要性，并提出了一个潜在的自闭症谱系障碍早期预测指标。

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引用次数: 0

Fear of hypoglycemia in parents of children with type 1 diabetes trained for intranasal glucagon use 接受鼻内胰高血糖素使用培训的 1 型糖尿病患儿家长对低血糖的恐惧。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-07-04 DOI: 10.1016/j.jpsychores.2024.111856

Alda Troncone , Alessia Piscopo , Angela Zanfardino , Antonietta Chianese , Crescenzo Cascella , Gaetana Affuso , Anna Borriello , Stefano Curto , Assunta Serena Rollato , Veronica Testa , Emanuele Miraglia del Giudice , Lorenza Magliano , Dario Iafusco

Objective

To investigate fear of hypoglycemia (FoH) in parents of children with type 1 diabetes (T1D) before and after undergoing training to learn intranasal (IN) glucagon administration.

Method

In this pre-test/post-test uncontrolled study 364 caregivers of patients with T1D (6–18 years) completed questionnaires measuring sociodemographic characteristics, diabetes-related factors (e.g., type of insulin therapy, glycemic control), and parents' trait anxiety. Parents' FoH was assessed at baseline (T0, training) and after nine months (T1). Two repeated-measure mixed analyses of covariance (ANCOVA) compared the FoH at T0 and at T1 and analyzed the moderating roles of anxiety proneness and type of insulin therapy, as well as of anxiety proneness and use of sensor. Age, T1D duration, HbA1c values, and SES were included as covariates.

Results

Parental FoH at T1 (M = 1.72; SE = 0.06/M = 1.57; SE = 0.09) was significantly lower than parental FoH at T0 (M = 1.89; SE = 0.06/M = 1.77; SE = 0.09). The group with high trait-anxiety had a higher level of FoH (M = 2.05; SE = 0.08/M = 1.89; SE = 0.12) than the group with low trait-anxiety (M = 1.57; SE = 0.08/M = 1.46; SE = 0.09) at both time points. SES was negatively associated with FoH at T0 (t = −2.87; p = .004/t = −2.87; p = .005). No other significant effects were found.

Conclusions

Training and educating parents on IN glucagon use can help them effectively manage hypoglycemic episodes and alleviate the fear that generally accompany such events.

目的研究1型糖尿病（T1D）患儿家长在接受鼻内注射胰高血糖素（IN）培训前后对低血糖（FoH）的恐惧：在这项前测/后测非对照研究中，364 名 1 型糖尿病患者（6-18 岁）的照顾者填写了调查问卷，调查内容包括社会人口学特征、糖尿病相关因素（如胰岛素治疗类型、血糖控制情况）以及父母的特质焦虑。在基线（T0，培训）和九个月后（T1）对家长的 FoH 进行了评估。两次重复测量混合协方差分析（ANCOVA）比较了 T0 和 T1 时的 FoH，并分析了焦虑倾向和胰岛素治疗类型以及焦虑倾向和传感器使用的调节作用。年龄、T1D持续时间、HbA1c值和社会经济地位被列为协变量：结果：T1时父母的FoH（M = 1.72; SE = 0.06/M = 1.57; SE = 0.09）明显低于T0时父母的FoH（M = 1.89; SE = 0.06/M = 1.77; SE = 0.09）。在两个时间点上，高特质焦虑组的 FoH 水平（M = 2.05；SE = 0.08/M = 1.89；SE = 0.12）均高于低特质焦虑组（M = 1.57；SE = 0.08/M = 1.46；SE = 0.09）。在 T0 阶段，SES 与 FoH 呈负相关（t = -2.87; p = .004/t = -2.87; p = .005）。没有发现其他重大影响：结论：对家长进行 IN 胰高血糖素使用方面的培训和教育可帮助他们有效控制低血糖发作，并减轻低血糖发生时家长的恐惧心理。

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引用次数: 0

Bidirectionality of LF when the movie makes you sad: Effects of negative emotions on heart rate variability among patients with major depression 电影让人悲伤时低频的双向性：负面情绪对重度抑郁症患者心率变异性的影响

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-06-29 DOI: 10.1016/j.jpsychores.2024.111855

Hayri Can Ozden , S. Can Gurel , Necla Ozer , Basaran Demir

Objectives

Heart rate variability (HRV) reflects the capacity to adapt to internal and environmental changes. Decreased HRV may indicate inadequate adaptive capacity. This study aims to investigate the relationship between the heart and brain's adaptive abilities, both at rest and when negative emotions are stimulated in depression.

Subjects and methods

The study included 30 patients (20 female, 10 male) with major depression (mean age = 29.8 ± 7.8) and 30 healthy controls, all of whom had similar characteristics in terms of age and gender, selected through convenience sampling. The patients were drug-free at the time of the assessment. Holter recordings were obtained while subjects watched videos stimulating anger, fear, sadness, and a neutral video, and at rest, HRV parameters were calculated. To control for interindividual variability and account for paired sampling, linear mixed effects models were employed.

Results

Watching the ‘sadness video’ led to an increase in low frequency band (LF) [LF change (Control vs depression); Difference:-620.80 df:107 t:-2.093 P:0.039] and LF/high frequency band ratio (LF/HF) [LF/HF change (control vs depression group); Difference:-1.718 df:105 t:-2.374 P:0.020] in the depression group. The video led to a decrease in LF and LF/HF in the controls. Although the differences between the conditions and interactions with the group were significant, the effects were independent of depression severity.

Conclusion

In depression, brain's regulatory effect on the heart differed from controls in the sadness condition, possibly due to increased arousal levels in subjects with depression and their inability to suppress sympathetic activity when a state of sadness is stimulated.

目标心率变异性（HRV）反映了对内部和环境变化的适应能力。心率变异性降低可能表明适应能力不足。本研究旨在探讨抑郁症患者在静息状态下和受到负面情绪刺激时，心脏和大脑适应能力之间的关系。研究对象和方法本研究通过方便抽样选取了 30 名重度抑郁症患者（20 名女性，10 名男性）（平均年龄 = 29.8 ± 7.8）和 30 名健康对照者，他们在年龄和性别方面都具有相似的特征。患者在接受评估时均未服药。在受试者观看刺激愤怒、恐惧、悲伤的视频和中性视频时采集 Holter 记录，并在休息时计算心率变异参数。结果观看 "悲伤视频 "导致低频段（LF）增加[LF 变化（对照组 vs 抑郁症组）；差值：-620.80 df:107 t:-2.093 P:0.039]和低频/高频段比率（LF/HF）[LF/HF变化（对照组 vs 抑郁症组）；差值：-1.718 df:105 t:-2.374 P:0.020]。视频导致对照组的 LF 和 LF/HF 下降。结论在抑郁状态下，大脑对心脏的调节作用在悲伤状态下与对照组不同，这可能是由于抑郁症患者的唤醒水平增加，以及他们在悲伤状态下无法抑制交感神经活动。

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引用次数: 0

The relationship between chronic disease variety and quantity and suicidal ideation: A cross-sectional study of NHANES 慢性病的种类和数量与自杀意念之间的关系：美国国家健康调查（NHANES）横断面研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-06-26 DOI: 10.1016/j.jpsychores.2024.111854

Shijie Guo , Guangwei Qing , Guang Yang

Background

This cross-sectional study examines the link between chronic diseases and suicidal thoughts in U.S. adults using 2013–2018 National Health and Nutrition Examination Survey (NHANES) data, aiming to identify potential risk factors for suicidal ideation.

Methods

Using NHANES data, we analyzed the association between various chronic conditions (hypertension, diabetes, asthma, etc.) and suicidal thoughts, employing logistic regression models adjusted for demographics and lifestyle factors.

Results

The analysis of 8891 participants revealed a significant association between suicidal thoughts and chronic diseases such as liver disease, diabetes, and asthma. The risk of suicidal ideation is higher with the number of chronic conditions.

Conclusion

Our findings suggest a strong link between the presence and number of chronic diseases and the risk of suicidal thoughts, emphasizing the importance of integrated care approaches that address both physical and mental health needs.

背景：这项横断面研究利用2013-2018年美国国家健康与营养调查（NHANES）数据，研究了美国成年人的慢性病与自杀念头之间的联系，旨在找出自杀念头的潜在风险因素：我们利用 NHANES 数据分析了各种慢性疾病（高血压、糖尿病、哮喘等）与自杀想法之间的关联，并采用逻辑回归模型对人口统计学和生活方式因素进行了调整：对 8891 名参与者进行的分析表明，自杀念头与肝病、糖尿病和哮喘等慢性疾病之间存在显著关联。结论：我们的研究结果表明，自杀念头与肝病、糖尿病和哮喘等慢性疾病之间存在密切联系：我们的研究结果表明，慢性疾病的存在和数量与自杀念头的风险之间存在密切联系，这强调了同时满足身体和心理健康需求的综合护理方法的重要性。

引用次数: 0

Comment on “beyond physical pain: A large-scale cohort study on endometriosis trends and mental health correlates” 评论 "超越身体疼痛：关于子宫内膜异位症趋势和心理健康相关因素的大规模队列研究 "的评论。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-06-23 DOI: 10.1016/j.jpsychores.2024.111853

Maria I. Zervou , George N. Goulielmos

引用次数: 0

Association of COVID-19 vaccination and anxiety symptoms: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort longitudinal study 接种 COVID-19 疫苗与焦虑症状的关系：以硬皮病患者为中心的干预网络 (SPIN) 队列纵向研究。

IF 3.5 2区医学 Q2 PSYCHIATRY

Journal of Psychosomatic Research

Pub Date : 2024-06-23 DOI: 10.1016/j.jpsychores.2024.111852

Gabrielle Virgili-Gervais , Richard S. Henry , Linda Kwakkenbos , Marie-Eve Carrier , Scott Patten , Susan J. Bartlett , Luc Mouthon , John Varga , Andrea Benedetti , Brett D. Thombs , the SPIN COVID-19 Patient Advisory Team , SPIN Investigators

Objective

Symptoms of anxiety increased early in the COVID-19 pandemic among people with systemic sclerosis (SSc) then returned to pre-pandemic levels, but this was an aggregate finding and did not evaluate whether vaccination may have contributed to reduced anxiety symptom levels. We investigated whether being vaccinated for COVID-19 was associated with reduced anxiety symptoms among people with SSc.

Methods

The longitudinal Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrollees. Participants completed measures bi-weekly through July 2020, then every 4 weeks afterwards through August 2022 (32 assessments). We used linear mixed models to evaluate longitudinal trends of PROMIS Anxiety 4a v1.0 anxiety domain scores and their association with vaccination.

Results

Among 517 participants included in analyses, 489 (95%) were vaccinated by September 2021, and no participants were vaccinated subsequently. Except for briefly at the beginning, when few had received a vaccine, and end, when only 28 participants remained unvaccinated, anxiety symptom trajectories were largely overlapping. Participants who were never vaccinated had higher anxiety symptoms by August 2022, but there were no other differences, and receiving a vaccination did not appear to change anxiety symptom trajectories meaningfully.

Conclusion

Vaccination did not appear to influence changes in anxiety symptoms among vulnerable people with SSc during the COVID-19 pandemic. This may be due to people restricting their behavior when they were unvaccinated and returning to more normal social engagement once vaccinated to maintain a steady level of anxiety symptoms.

目的：系统性硬化症（SSc）患者的焦虑症状在COVID-19大流行初期有所增加，随后又恢复到大流行前的水平，但这只是一个综合结果，并未评估接种疫苗是否有助于降低焦虑症状水平。我们研究了接种 COVID-19 疫苗是否与系统性硬化症患者焦虑症状的减轻有关：纵向硬皮病患者中心干预网络（SPIN）COVID-19队列于2020年4月启动，包括正在进行的SPIN队列的参与者和外部注册者。参与者在 2020 年 7 月之前每两周完成一次评估，之后每 4 周完成一次评估，直至 2022 年 8 月（32 次评估）。我们使用线性混合模型来评估 PROMIS Anxiety 4a v1.0 焦虑域得分的纵向趋势及其与疫苗接种的关系：在纳入分析的517名参与者中，489人（95%）在2021年9月之前接种了疫苗，没有参与者在之后接种疫苗。除了在开始和结束时有过短暂的接种，当时只有 28 名参与者未接种疫苗，焦虑症状轨迹在很大程度上是重叠的。到 2022 年 8 月，从未接种过疫苗的参与者焦虑症状较重，但并无其他差异，接种疫苗似乎并没有对焦虑症状轨迹产生有意义的改变：结论：在COVID-19大流行期间，接种疫苗似乎不会影响易感 SSc 患者焦虑症状的变化。这可能是由于患者在未接种疫苗时限制了自己的行为，而在接种疫苗后则恢复了更正常的社交活动，从而保持了焦虑症状的稳定水平。

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引用次数: 0