Pub Date : 2025-12-13DOI: 10.1016/j.jpsychores.2025.112500
Petra Engelmann, Mareike Busmann, Bernd Löwe, Paul Hüsing
Background
Biopsychosocial mechanisms are assumed to underlie the chronification of back pain; however, potentially relevant factors have mainly been examined in isolation rather than within comprehensive aetiological models. This study investigated risk factors of chronic back pain based on a current biopsychosocial model for persistent somatic symptoms.
Methods
Within the prospective cohort study IDRIS (“From the identification of biopsychosocial risk factors to an increase in pain-related self-efficacy – The online-based conveyance of an explanatory model for chronic back pain”), German adults with (sub)acute back pain (< 12 weeks) completed online questionnaires on biopsychosocial variables at baseline, 1-month and 3-month follow-up. Possible predisposing and maintaining predictors of chronic back pain at 3 months were tested in linear regression models.
Findings
Between December 2022 and July 2024, 280 individuals from the general population with (sub)acute back pain (mean age 37.52 (SD 12.41) years; 65 % female) completed all assessments. Predictors of chronic back pain at 3 months were dysfunctional symptom expectations at 1-month follow-up (ß = 0.25, p < 0.001) and high baseline pain severity grades (highest grade: ß = 0.18, p < 0.01). Other postulated variables did not predict pain chronification.
Interpretation
This study supports the role of negative pain-related beliefs in the transition from acute to chronic back pain and suggests addressing dysfunctional symptom expectations in secondary prevention interventions to mitigate the risk of pain chronification. Future research should assess postulated predisposing factors for chronic back pain in clinical populations over longer timeframes to evaluate their long-term predictive value.
Funding
Stiftung Psychosomatik der Wirbelsäulenerkrankungen.
背景:生物心理社会机制被认为是背痛慢性化的基础;然而,潜在的相关因素主要是孤立的,而不是综合的病因学模型。本研究基于当前持续躯体症状的生物心理社会模型调查了慢性背痛的危险因素。方法:在前瞻性队列研究IDRIS(“从生物心理社会风险因素的识别到疼痛相关自我效能的增加——慢性背痛的在线解释模型”)中,患有(亚)急性背痛(< 12周)的德国成年人在基线、1个月和3个月的随访中完成了生物心理社会变量的在线问卷调查。在线性回归模型中检验3个月时慢性背痛的可能易感因素和维持因素。研究结果:在2022年12月至2024年7月期间,来自普通人群的280例(亚)急性背痛患者(平均年龄37.52岁(SD 12.41岁);(65%为女性)完成了所有评估。3个月时慢性背痛的预测因子是1个月随访时的功能失调症状预期(ß = 0.25, p)。解释:本研究支持疼痛相关的消极信念在从急性到慢性背痛转变中的作用,并建议在二级预防干预中解决功能失调症状预期,以减轻疼痛慢性化的风险。未来的研究应该在更长的时间框架内评估临床人群中慢性背痛的假定诱发因素,以评估其长期预测价值。资助:Stiftung Psychosomatik der Wirbelsäulenerkrankungen
{"title":"Biopsychosocial risk factors for the transition from acute to chronic back pain: A prospective cohort study","authors":"Petra Engelmann, Mareike Busmann, Bernd Löwe, Paul Hüsing","doi":"10.1016/j.jpsychores.2025.112500","DOIUrl":"10.1016/j.jpsychores.2025.112500","url":null,"abstract":"<div><h3>Background</h3><div>Biopsychosocial mechanisms are assumed to underlie the chronification of back pain; however, potentially relevant factors have mainly been examined in isolation rather than within comprehensive aetiological models. This study investigated risk factors of chronic back pain based on a current biopsychosocial model for persistent somatic symptoms.</div></div><div><h3>Methods</h3><div>Within the prospective cohort study IDRIS (“From the identification of biopsychosocial risk factors to an increase in pain-related self-efficacy – The online-based conveyance of an explanatory model for chronic back pain”), German adults with (sub)acute back pain (< 12 weeks) completed online questionnaires on biopsychosocial variables at baseline, 1-month and 3-month follow-up. Possible predisposing and maintaining predictors of chronic back pain at 3 months were tested in linear regression models.</div></div><div><h3>Findings</h3><div>Between December 2022 and July 2024, 280 individuals from the general population with (sub)acute back pain (mean age 37.52 (SD 12.41) years; 65 % female) completed all assessments. Predictors of chronic back pain at 3 months were dysfunctional symptom expectations at 1-month follow-up (<em>ß</em> = 0.25, <em>p</em> < 0.001) and high baseline pain severity grades (highest grade: <em>ß</em> = 0.18, <em>p</em> < 0.01). Other postulated variables did not predict pain chronification.</div></div><div><h3>Interpretation</h3><div>This study supports the role of negative pain-related beliefs in the transition from acute to chronic back pain and suggests addressing dysfunctional symptom expectations in secondary prevention interventions to mitigate the risk of pain chronification. Future research should assess postulated predisposing factors for chronic back pain in clinical populations over longer timeframes to evaluate their long-term predictive value.</div></div><div><h3>Funding</h3><div>Stiftung Psychosomatik der Wirbelsäulenerkrankungen.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112500"},"PeriodicalIF":3.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-13DOI: 10.1016/j.jpsychores.2025.112499
Iris Knoop , Annie S.K. Jones , Sam Norton , Nicholas Gall , Rona Moss-Morris
Purpose
Postural Orthostatic Tachycardia Syndrome (POTS) is a debilitating condition of the autonomic nervous system with no clear referral, diagnosis, and treatment pathways. Patients experience high levels of symptoms and moderate levels of distress. The purpose of this study was to explore biopsychosocial factors associated with distress in those under investigation for POTS, to identify potential targets for intervention.
Methods
A longitudinal, quantitative survey. Participants (n = 149) completed demographic, psychosocial, and symptom questionnaires prior to a diagnostic POTS clinic visit and 6 months follow-up (n = 98). Correlation and regression analyses were used to identify factors associated with distress at baseline (within one month before diagnostic hospital visit) and at 6 months follow up.
Results
At baseline, distress levels were moderate and greater symptom focusing, all-or-nothing and avoidance behaviours, threatening views of the illness, emotional reactivity, cardiac anxiety, POTS symptoms, number of specialists seen, lower social support, and younger age were significantly associated with higher levels of baseline distress. The baseline regression model including all demographic, clinical, and psychosocial factors explained 61.2 % of the variance in distress, with the psychosocial variables collectively explaining 55.6 % of this variance (F = 11.06, p < .001). There was no significant difference between distress levels at baseline and follow-up. Psychosocial variables explained 4.7 % of the variance (F = 0.76, p = .665) in changes in distress scores over 6 months. Baseline distress scores accounted for the vast majority of variance in distress at follow-up.
Conclusions
This study identified key novel psychosocial factors that were significantly associated with distress which could be potential targets for intervention. Additional factors such as younger age and a higher number of specialists seen were also associated with higher levels of distress, which merits attention when assessing patients' psychological wellbeing this patient group. Distress levels did not significantly change following the specialist consultation and investigation.
{"title":"Biopsychosocial factors associated with distress in people with suspected postural orthostatic tachycardia syndrome (POTS): A longitudinal regression and correlation study","authors":"Iris Knoop , Annie S.K. Jones , Sam Norton , Nicholas Gall , Rona Moss-Morris","doi":"10.1016/j.jpsychores.2025.112499","DOIUrl":"10.1016/j.jpsychores.2025.112499","url":null,"abstract":"<div><h3>Purpose</h3><div>Postural Orthostatic Tachycardia Syndrome (POTS) is a debilitating condition of the autonomic nervous system with no clear referral, diagnosis, and treatment pathways. Patients experience high levels of symptoms and moderate levels of distress. The purpose of this study was to explore biopsychosocial factors associated with distress in those under investigation for POTS, to identify potential targets for intervention.</div></div><div><h3>Methods</h3><div>A longitudinal, quantitative survey. Participants (<em>n</em> = 149) completed demographic, psychosocial, and symptom questionnaires prior to a diagnostic POTS clinic visit and 6 months follow-up (<em>n</em> = 98). Correlation and regression analyses were used to identify factors associated with distress at baseline (within one month before diagnostic hospital visit) and at 6 months follow up.</div></div><div><h3>Results</h3><div>At baseline, distress levels were moderate and greater symptom focusing, all-or-nothing and avoidance behaviours, threatening views of the illness, emotional reactivity, cardiac anxiety, POTS symptoms, number of specialists seen, lower social support, and younger age were significantly associated with higher levels of baseline distress. The baseline regression model including all demographic, clinical, and psychosocial factors explained 61.2 % of the variance in distress, with the psychosocial variables collectively explaining 55.6 % of this variance (F = 11.06, <em>p</em> < .001). There was no significant difference between distress levels at baseline and follow-up. Psychosocial variables explained 4.7 % of the variance (F = 0.76, <em>p</em> = .665) in changes in distress scores over 6 months. Baseline distress scores accounted for the vast majority of variance in distress at follow-up.</div></div><div><h3>Conclusions</h3><div>This study identified key novel psychosocial factors that were significantly associated with distress which could be potential targets for intervention. Additional factors such as younger age and a higher number of specialists seen were also associated with higher levels of distress, which merits attention when assessing patients' psychological wellbeing this patient group. Distress levels did not significantly change following the specialist consultation and investigation.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"201 ","pages":"Article 112499"},"PeriodicalIF":3.3,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145776321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1016/j.jpsychores.2025.112496
Celal Akdemir , Suna Aşkın Turan , Mücahit Furkan Balcı , Süleyman Özen , Nefise Şeker , Denizhan Bayramoğlu , Zeynep Bayramoğlu , Muzaffer Sancı
Purpose
This study evaluated associations between preoperative sleep quality, anxiety, and short-term postoperative outcomes in patients undergoing gynecologic oncology surgery.
Methods
This prospective observational study included 72 women undergoing open gynecologic cancer surgery. Preoperative sleep quality and anxiety were assessed 24–48 h before surgery using the Pittsburgh Sleep Quality Index (PSQI) and the Beck Anxiety Inventory (BAI). Postoperative pain was measured using the Numerical Rating Scale (NRS) at 0, 4, 8, 12, and 24 h. Complications, rescue analgesia use, and length of stay were recorded.
Results
Poor sleep quality (%31.9) and clinically significant anxiety (%19.4) were both associated with higher mean postoperative pain scores (PSQI ≥5: 6.3 ± 1.2 vs 5.1 ± 1.3, p = 0.002; BAI ≥16: 6.5 ± 1.1 vs 5.2 ± 1.4, p = 0.001). In adjusted analyses, higher PSQI (β = 0.112, 95 % CI 0.039–0.185, p = 0.003) and higher BAI scores (β = 0.044, 95 % CI 0.023–0.065, p < 0.001) remained significantly associated with increased mean pain. Poor sleep quality was also linked to longer hospitalization (4 vs 3 days, p < 0.001) and higher complication rates (%52.2 vs %12.2, p < 0.001). Elevated anxiety was similarly associated with higher complication rates (%57.1 vs %17.2, p = 0.004) and more frequent rescue analgesia use (%64.3 vs %29.3, p = 0.014).
Conclusion
Preoperative sleep disturbances and anxiety are significantly associated with worse postoperative pain, higher complication rates, and prolonged recovery; routine screening and targeted interventions may therefore improve surgical outcomes.
Trial registration
The study was retrospectively registered at ClinicalTrials.gov (Identifier: NCT07036549) on June 24, 2025.
目的:本研究评估妇科肿瘤手术患者术前睡眠质量、焦虑和术后短期预后之间的关系。方法本前瞻性观察研究纳入72例接受开放性妇科肿瘤手术的妇女。术前24-48 h采用匹兹堡睡眠质量指数(PSQI)和贝克焦虑量表(BAI)评估睡眠质量和焦虑。术后0、4、8、12和24 h采用数值评定量表(NRS)测量疼痛。记录并发症、抢救镇痛使用情况和住院时间。结果spoor睡眠质量(%31.9)和临床显著焦虑(%19.4)均与较高的术后平均疼痛评分相关(PSQI≥5:6.3±1.2 vs 5.1±1.3,p = 0.002; BAI≥16:6.5±1.1 vs 5.2±1.4,p = 0.001)。在校正分析中,较高的PSQI (β = 0.112, 95% CI 0.039-0.185, p = 0.003)和较高的BAI评分(β = 0.044, 95% CI 0.023-0.065, p < 0.001)仍然与平均疼痛增加显著相关。睡眠质量差还与住院时间较长(4天对3天,p < 0.001)和并发症发生率较高(% 52.2%对% 12.2%,p < 0.001)有关。焦虑升高同样与更高的并发症发生率(%57.1 vs %17.2, p = 0.004)和更频繁的急救镇痛使用相关(%64.3 vs %29.3, p = 0.014)。结论术前睡眠障碍和焦虑与术后疼痛加重、并发症发生率高、恢复时间长有显著关系;因此,常规筛查和有针对性的干预可以改善手术结果。试验注册该研究于2025年6月24日在ClinicalTrials.gov(标识符:NCT07036549)上回顾性注册。
{"title":"Preoperative sleep quality and anxiety as predictors of postoperative pain and recovery in Gynecologic oncology surgery: A prospective observational study","authors":"Celal Akdemir , Suna Aşkın Turan , Mücahit Furkan Balcı , Süleyman Özen , Nefise Şeker , Denizhan Bayramoğlu , Zeynep Bayramoğlu , Muzaffer Sancı","doi":"10.1016/j.jpsychores.2025.112496","DOIUrl":"10.1016/j.jpsychores.2025.112496","url":null,"abstract":"<div><h3>Purpose</h3><div>This study evaluated associations between preoperative sleep quality, anxiety, and short-term postoperative outcomes in patients undergoing gynecologic oncology surgery.</div></div><div><h3>Methods</h3><div>This prospective observational study included 72 women undergoing open gynecologic cancer surgery. Preoperative sleep quality and anxiety were assessed 24–48 h before surgery using the Pittsburgh Sleep Quality Index (PSQI) and the Beck Anxiety Inventory (BAI). Postoperative pain was measured using the Numerical Rating Scale (NRS) at 0, 4, 8, 12, and 24 h. Complications, rescue analgesia use, and length of stay were recorded.</div></div><div><h3>Results</h3><div>Poor sleep quality (%31.9) and clinically significant anxiety (%19.4) were both associated with higher mean postoperative pain scores (PSQI ≥5: 6.3 ± 1.2 vs 5.1 ± 1.3, <em>p</em> = 0.002; BAI ≥16: 6.5 ± 1.1 vs 5.2 ± 1.4, <em>p</em> = 0.001). In adjusted analyses, higher PSQI (β = 0.112, 95 % CI 0.039–0.185, <em>p</em> = 0.003) and higher BAI scores (β = 0.044, 95 % CI 0.023–0.065, <em>p</em> < 0.001) remained significantly associated with increased mean pain. Poor sleep quality was also linked to longer hospitalization (4 vs 3 days, <em>p</em> < 0.001) and higher complication rates (%52.2 vs %12.2, p < 0.001). Elevated anxiety was similarly associated with higher complication rates (%57.1 vs %17.2, <em>p</em> = 0.004) and more frequent rescue analgesia use (%64.3 vs %29.3, <em>p</em> = 0.014).</div></div><div><h3>Conclusion</h3><div>Preoperative sleep disturbances and anxiety are significantly associated with worse postoperative pain, higher complication rates, and prolonged recovery; routine screening and targeted interventions may therefore improve surgical outcomes.</div></div><div><h3>Trial registration</h3><div>The study was retrospectively registered at <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> (Identifier: <span><span>NCT07036549</span><svg><path></path></svg></span>) on June 24, 2025.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"201 ","pages":"Article 112496"},"PeriodicalIF":3.3,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1016/j.jpsychores.2025.112495
Ferenc Köteles , Michael Witthöft , Anne-Kathrin Bräscher , Josef Bailer , Steven Nordin
Objective
Our knowledge on the prevalence of self-reported sensitivities to environmental factors is poor. The lack of accepted criteria/assessment makes findings of different studies difficult to compare; the way of assessment might play a role in the reported prevalence rates. The present study aimed to report the prevalence rates of five environmental sensitivities for the German general population, to compare three of them with Swedish and Finnish data, and to demonstrate the impact of strictness of criterion on the results.
Methods
Data from a German (n = 2515), a Swedish (n = 3253) and a Finnish (n = 1467) population-based survey was used. Sentitivities were rated on ordinal scales in all samples.
Results
In the German sample, about 25 % of participants reported mild reactions to sounds, chemicals, and buildings, and about 10 % to electromagnetic fields (EMFs) and wind turbines, with a similar pattern for strong reactions, but with proportions of 1–2 %. Data from the Nordic countries show consistent similarities between these two countries, with prevalences exceeding 34 % for mild reactions to chemicals and sounds and about 5 % to EMFs, with a similar pattern for strong reactions, but with proportions of 1–8 %. Prevalence of sensitivity to EMFs was higher, whereas prevalence of sensitivity to chemicals and sounds was lower in Germany. Classification criteria significantly impacted the reported prevalence rates.
Conclusion
Various environmental sensitivities affect a considerable proportion of the general populations of the three countries. To improve comparability, self-report assessment of sensitivities should be based on at least an ordinal scale instead of the widely used yes-or-no question.
{"title":"Prevalence of self-reported sensitivities to various environmental factors in Germany, Sweden, and Finland based on multiple classification criteria","authors":"Ferenc Köteles , Michael Witthöft , Anne-Kathrin Bräscher , Josef Bailer , Steven Nordin","doi":"10.1016/j.jpsychores.2025.112495","DOIUrl":"10.1016/j.jpsychores.2025.112495","url":null,"abstract":"<div><h3>Objective</h3><div>Our knowledge on the prevalence of self-reported sensitivities to environmental factors is poor. The lack of accepted criteria/assessment makes findings of different studies difficult to compare; the way of assessment might play a role in the reported prevalence rates. The present study aimed to report the prevalence rates of five environmental sensitivities for the German general population, to compare three of them with Swedish and Finnish data, and to demonstrate the impact of strictness of criterion on the results.</div></div><div><h3>Methods</h3><div>Data from a German (<em>n</em> = 2515), a Swedish (<em>n</em> = 3253) and a Finnish (<em>n</em> = 1467) population-based survey was used. Sentitivities were rated on ordinal scales in all samples.</div></div><div><h3>Results</h3><div>In the German sample, about 25 % of participants reported mild reactions to sounds, chemicals, and buildings, and about 10 % to electromagnetic fields (EMFs) and wind turbines, with a similar pattern for strong reactions, but with proportions of 1–2 %. Data from the Nordic countries show consistent similarities between these two countries, with prevalences exceeding 34 % for mild reactions to chemicals and sounds and about 5 % to EMFs, with a similar pattern for strong reactions, but with proportions of 1–8 %. Prevalence of sensitivity to EMFs was higher, whereas prevalence of sensitivity to chemicals and sounds was lower in Germany. Classification criteria significantly impacted the reported prevalence rates.</div></div><div><h3>Conclusion</h3><div>Various environmental sensitivities affect a considerable proportion of the general populations of the three countries. To improve comparability, self-report assessment of sensitivities should be based on at least an ordinal scale instead of the widely used yes-or-no question.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"201 ","pages":"Article 112495"},"PeriodicalIF":3.3,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145758128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-05DOI: 10.1016/j.jpsychores.2025.112493
Molly Howland , Nicolas Thompson , Arushi Mahajan , Nona Nichols , Marielle Collins , Jack H. Owens Jr , Adele Viguera
Objective
Misdiagnosis of depression and delirium by non-psychiatric clinicians is common. Depression over-diagnosis can cause stigmatization of normal emotional reactions and delays in addressing delirium. We performed a multisite retrospective chart review to examine diagnostic agreement between non-psychiatric services and the consultation-liaison psychiatry (CLP) service.
Methods
We reviewed inpatient depression and delirium referrals across two Cleveland Clinic sites. Agreement between referral reason and CLP service diagnosis was assessed. We fit multivariable logistic regression models for the dependent variables of depression overdiagnosis and delirium masquerading as depression, with independent variables that included the primary team discipline and demographic and clinical variables.
Results
Diagnostic agreement for delirium, strict depression diagnosis, and broad depression diagnosis were 88 %, 67 %, and 80 %, respectively. Of patients referred for depression who did not receive a CL psychiatry diagnosis of depression, 49 % were diagnosed with adjustment disorder, 18 % with anxiety/OCD, 16 % with delirium, and 4 % with neurocognitive disorders. Older age and prior psychiatric diagnoses decreased the likelihood of depression overdiagnosis. Psychotropic medication use increased the likelihood of delirium misdiagnosed as depression.
Conclusion
Primary services overidentify depression and more accurately identify delirium. However, given that most alternative diagnoses were anxiety disorders or adjustment disorders, primary services seem adept at identifying psychological distress, which may be related to destigmatization and education efforts by psychiatrists. Primary services recognize prior psychiatric diagnoses as a depression risk factor and demonstrate awareness of geriatric presentations. However, prior psychotropic use may introduce bias. Further research, including direct knowledge and attitude assessments, is needed.
{"title":"Depressed or delirious? Overdiagnosis of depression in medically hospitalized patients","authors":"Molly Howland , Nicolas Thompson , Arushi Mahajan , Nona Nichols , Marielle Collins , Jack H. Owens Jr , Adele Viguera","doi":"10.1016/j.jpsychores.2025.112493","DOIUrl":"10.1016/j.jpsychores.2025.112493","url":null,"abstract":"<div><h3>Objective</h3><div>Misdiagnosis of depression and delirium by non-psychiatric clinicians is common. Depression over-diagnosis can cause stigmatization of normal emotional reactions and delays in addressing delirium. We performed a multisite retrospective chart review to examine diagnostic agreement between non-psychiatric services and the consultation-liaison psychiatry (CLP) service.</div></div><div><h3>Methods</h3><div>We reviewed inpatient depression and delirium referrals across two Cleveland Clinic sites. Agreement between referral reason and CLP service diagnosis was assessed. We fit multivariable logistic regression models for the dependent variables of depression overdiagnosis and delirium masquerading as depression, with independent variables that included the primary team discipline and demographic and clinical variables.</div></div><div><h3>Results</h3><div>Diagnostic agreement for delirium, strict depression diagnosis, and broad depression diagnosis were 88 %, 67 %, and 80 %, respectively. Of patients referred for depression who did not receive a CL psychiatry diagnosis of depression, 49 % were diagnosed with adjustment disorder, 18 % with anxiety/OCD, 16 % with delirium, and 4 % with neurocognitive disorders. Older age and prior psychiatric diagnoses decreased the likelihood of depression overdiagnosis. Psychotropic medication use increased the likelihood of delirium misdiagnosed as depression.</div></div><div><h3>Conclusion</h3><div>Primary services overidentify depression and more accurately identify delirium. However, given that most alternative diagnoses were anxiety disorders or adjustment disorders, primary services seem adept at identifying psychological distress, which may be related to destigmatization and education efforts by psychiatrists. Primary services recognize prior psychiatric diagnoses as a depression risk factor and demonstrate awareness of geriatric presentations. However, prior psychotropic use may introduce bias. Further research, including direct knowledge and attitude assessments, is needed.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"201 ","pages":"Article 112493"},"PeriodicalIF":3.3,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jpsychores.2025.112480
Haitham Abu Khadija , Nizar Abu Hamdeh , Duha Najajra , Wafiq Othman , Hamza A. Abdul-Hafez , Anwar Zahran , Omar Heih , Yahya Z. Fraitekh , Mohammad Masu'd , Mahdi Awwad , Idiberto José Zotarelli Filho , Alaa Zayed , Moaath Sawalha , Sara Ismail , Izzeddin Swidan , Omar Abu-Hamda , Oday Nana , Kasem Hamoudy , Basem Bali , Moaath Nairat , Mohammad Alnees
Background
Hallucinations are underrecognized neuropsychiatric complications after cardiac surgery. Data on incidence and type-specific predictors in coronary artery bypass grafting (CABG) and valvular surgery are limited.
Methods
We conducted a multicenter prospective cohort study (September 2022 to May 2025) across West Bank cardiac surgery centers. A total of 1332 adults (997 CABG, 335 valve) were assessed daily for 7 days postoperatively using the Questionnaire for Psychotic Experiences. Predictors of visual and auditory hallucinations evaluated with Cox proportional hazards models.
Results
Visual hallucinations occurred in 11.5 % of CABG patients and 10.0 % of valve surgery patients, while auditory hallucinations were reported in 7.0 % and 5.0 %, respectively. In the CABG group, the multivariable Cox regression models stratified by hospital showed that auditory hallucinations were significantly associated with lower left ventricular ejection fraction (HR = 1.05 per 1 % decrease; 95 % CI 1.01–1.09), longer aortic cross-clamp time (HR = 1.01 per minute; 95 % CI1.0004–1.02), and immunosuppressive therapy (HR = 4.81; 95 % CI 1.13–20.53). Postoperative blood transfusion was associated with an increased risk of visual hallucinations in univariate analysis (HR = 1.87; 95 % CI 1.05–3.33), but the association became borderline after adjustment (HR = 1.97; 95 % CI 0.95–4.09). Among the valve surgery cohort, the hospital-stratified models indicated that prolonged postoperative ventilation was independently protective against visual hallucinations (adjusted HR = 0.78; 95 % CI 0.68–0.90), whereas noradrenalin use (adjusted HR = 6.07; 95 % CI 2.18–16.93) and immunosuppressive therapy (adjusted HR = 5.13; 95 % CI 1.14–23.09) markedly increased the risk. For auditory hallucinations in valve surgery patients, adrenaline exposure emerged as a significant independent predictor (adjusted HR = 3.40; 95 % CI 1.21–9.54).
Conclusions
Postoperative hallucinations affected ∼1 in 10 patients; visual hallucinations were more frequent, auditory hallucinations linked to stress and medications, with risks varying by surgery type, supporting tailored monitoring and prevention.
背景:幻觉是心脏手术后未被充分认识的神经精神并发症。关于冠状动脉旁路移植术(CABG)和瓣膜手术的发生率和类型特异性预测因素的数据有限。方法:我们在西岸心脏外科中心进行了一项多中心前瞻性队列研究(2022年9月至2025年5月)。共有1332名成人(997例冠脉搭桥,335例瓣膜)在术后7天内每天使用精神病经历问卷进行评估。用Cox比例风险模型评估视觉和听觉幻觉的预测因子。结果:冠脉搭桥患者出现视幻觉的比例为11.5%,瓣膜手术患者出现视幻觉的比例为10.0%,出现听幻觉的比例为7.0%,出现听幻觉的比例为5.0%。在CABG组,医院分层的多变量Cox回归模型显示,幻听与左室射血分数降低(HR = 1.05 / 1%; 95% CI 1.01-1.09)、主动脉交叉夹持时间延长(HR = 1.01 / min; 95% CI1.0004-1.02)和免疫抑制治疗(HR = 4.81; 95% CI 1.13-20.53)显著相关。单因素分析显示,术后输血与视幻觉风险增加相关(HR = 1.87; 95% CI 1.05-3.33),但调整后相关性变为临界(HR = 1.97; 95% CI 0.95-4.09)。在瓣膜手术队列中,医院分层模型显示,术后延长通气对视幻觉有独立的保护作用(调整后的HR = 0.78; 95% CI 0.68-0.90),而使用去甲肾上腺素(调整后的HR = 6.07; 95% CI 2.18-16.93)和免疫抑制治疗(调整后的HR = 5.13; 95% CI 1.14-23.09)显著增加了视幻觉的风险。对于瓣膜手术患者的幻听,肾上腺素暴露是一个重要的独立预测因子(调整后HR = 3.40; 95% CI 1.21-9.54)。结论:术后10例患者中有1例出现幻觉;视觉幻觉更频繁,听觉幻觉与压力和药物有关,风险因手术类型而异,支持量身定制的监测和预防。
{"title":"Postoperative visual and auditory hallucinations after cardiac surgery: VAACS umbrella study","authors":"Haitham Abu Khadija , Nizar Abu Hamdeh , Duha Najajra , Wafiq Othman , Hamza A. Abdul-Hafez , Anwar Zahran , Omar Heih , Yahya Z. Fraitekh , Mohammad Masu'd , Mahdi Awwad , Idiberto José Zotarelli Filho , Alaa Zayed , Moaath Sawalha , Sara Ismail , Izzeddin Swidan , Omar Abu-Hamda , Oday Nana , Kasem Hamoudy , Basem Bali , Moaath Nairat , Mohammad Alnees","doi":"10.1016/j.jpsychores.2025.112480","DOIUrl":"10.1016/j.jpsychores.2025.112480","url":null,"abstract":"<div><h3>Background</h3><div>Hallucinations are underrecognized neuropsychiatric complications after cardiac surgery. Data on incidence and type-specific predictors in coronary artery bypass grafting (CABG) and valvular surgery are limited.</div></div><div><h3>Methods</h3><div>We conducted a multicenter prospective cohort study (September 2022 to May 2025) across West Bank cardiac surgery centers. A total of 1332 adults (997 CABG, 335 valve) were assessed daily for 7 days postoperatively using the Questionnaire for Psychotic Experiences. Predictors of visual and auditory hallucinations evaluated with Cox proportional hazards models.</div></div><div><h3>Results</h3><div>Visual hallucinations occurred in 11.5 % of CABG patients and 10.0 % of valve surgery patients, while auditory hallucinations were reported in 7.0 % and 5.0 %, respectively. In the CABG group, the multivariable Cox regression models stratified by hospital showed that auditory hallucinations were significantly associated with lower left ventricular ejection fraction (HR = 1.05 per 1 % decrease; 95 % CI 1.01–1.09), longer aortic cross-clamp time (HR = 1.01 per minute; 95 % CI1.0004–1.02), and immunosuppressive therapy (HR = 4.81; 95 % CI 1.13–20.53). Postoperative blood transfusion was associated with an increased risk of visual hallucinations in univariate analysis (HR = 1.87; 95 % CI 1.05–3.33), but the association became borderline after adjustment (HR = 1.97; 95 % CI 0.95–4.09). Among the valve surgery cohort, the hospital-stratified models indicated that prolonged postoperative ventilation was independently protective against visual hallucinations (adjusted HR = 0.78; 95 % CI 0.68–0.90), whereas noradrenalin use (adjusted HR = 6.07; 95 % CI 2.18–16.93) and immunosuppressive therapy (adjusted HR = 5.13; 95 % CI 1.14–23.09) markedly increased the risk. For auditory hallucinations in valve surgery patients, adrenaline exposure emerged as a significant independent predictor (adjusted HR = 3.40; 95 % CI 1.21–9.54).</div></div><div><h3>Conclusions</h3><div>Postoperative hallucinations affected ∼1 in 10 patients; visual hallucinations were more frequent, auditory hallucinations linked to stress and medications, with risks varying by surgery type, supporting tailored monitoring and prevention.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"202 ","pages":"Article 112480"},"PeriodicalIF":3.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146020540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1016/j.jpsychores.2025.112428
A. Tuborgh , S.W. Svendsen , A. Elklit , J. Hunter , E. Ornbol , J.S. Jensen , A. Schröder , J.F. Nielsen , E.T. Næss-Schmidt , M.M. Thastum , C.U. Rask
Background
Insecure attachment may negatively affect symptom reporting and disability in physical illness, but research on its influence on treatment outcome is scarce. We explored if insecure attachment: 1) impacted overall treatment outcome, and 2) moderated the effect of an early interdisciplinary intervention in young persons with long-lasting postconcussion symptoms (PCS).
Methods
This is a secondary analysis of the ‘Get going After concussIoN’ (GAIN) trial. Participants aged 15–30 years were randomised to either GAIN or enhanced usual care (EUC). Attachment insecurity (anxiety and avoidance) was measured at baseline with the Experiences in Close Relationships-Relationship Structure Questionnaire, and treatment outcome measured by PCS was recorded by the Rivermead Post-Concussion Symptoms Questionnaire. The impact of insecure attachment was explored using both a dimensional and a categorical approach. Multiple linear regression analysis was applied.
Results
Ninety-one out of 112 trial participants were included. Neither attachment anxiety nor attachment avoidance independently affected the treatment outcome. However, in a categorical approach, fearful patients (i.e., combined high anxiety and high avoidance) had a less favourable outcome (β = 9.98, 95 % CI: 4.05; 15.92, p = 0.001) than nonfearful patients. Insecure attachment did not moderate the superior effect of GAIN on PCS compared with EUC.
Conclusion
This study provided weak support for an association between insecure attachment and the outcome of an early intervention against long-lasting PCS in young persons after a concussion. However, patients with fearful attachment may represent a more vulnerable subgroup. Further research is needed to explore if attachment-informed intervention may enhance treatment prospects.
背景:不安全依恋可能对躯体疾病的症状报告和残疾产生负面影响,但对其对治疗结果影响的研究较少。我们探讨了不安全依恋是否:1)影响整体治疗结果,2)调节早期跨学科干预对长期脑震荡后症状(PCS)的影响。方法:这是对“脑震荡后恢复”(GAIN)试验的二次分析。15-30岁的参与者被随机分配到GAIN组或强化常规护理组(EUC)。依恋不安全感(焦虑和回避)基线采用亲密关系体验-关系结构问卷测量,治疗结果采用Rivermead脑震荡后症状问卷记录。不安全依恋的影响是用维度和分类的方法来探讨的。采用多元线性回归分析。结果:112名试验参与者中有91人入选。依恋焦虑和依恋回避均未独立影响治疗结果。然而,在分类方法中,恐惧患者(即高度焦虑和高度回避的结合)的结果不如无恐惧患者(β = 9.98, 95% CI: 4.05; 15.92, p = 0.001)。与EUC相比,不安全依恋并没有调节GAIN对PCS的优越效果。结论:本研究为不安全依恋与青少年脑震荡后长期PCS的早期干预结果之间的关联提供了微弱的支持。然而,有恐惧依恋的患者可能是一个更脆弱的亚群。需要进一步的研究来探索依恋知情干预是否可以提高治疗前景。
{"title":"Corrigendum to “Does insecure attachment affect treatment outcome in young persons with post-concussion symptoms? A secondary analysis of the GAIN trial”. J Psychosom Res. 2023 Jan;164:111100","authors":"A. Tuborgh , S.W. Svendsen , A. Elklit , J. Hunter , E. Ornbol , J.S. Jensen , A. Schröder , J.F. Nielsen , E.T. Næss-Schmidt , M.M. Thastum , C.U. Rask","doi":"10.1016/j.jpsychores.2025.112428","DOIUrl":"10.1016/j.jpsychores.2025.112428","url":null,"abstract":"<div><h3>Background</h3><div>Insecure attachment may negatively affect symptom reporting and disability in physical illness, but research on its influence on treatment outcome is scarce. We explored if insecure attachment: 1) impacted overall treatment outcome, and 2) moderated the effect of an early interdisciplinary intervention in young persons with long-lasting postconcussion symptoms (PCS).</div></div><div><h3>Methods</h3><div>This is a secondary analysis of the ‘Get going After concussIoN’ (GAIN) trial. Participants aged 15–30 years were randomised to either GAIN or enhanced usual care (EUC). Attachment insecurity (anxiety and avoidance) was measured at baseline with the Experiences in Close Relationships-Relationship Structure Questionnaire, and treatment outcome measured by PCS was recorded by the Rivermead Post-Concussion Symptoms Questionnaire. The impact of insecure attachment was explored using both a dimensional and a categorical approach. Multiple linear regression analysis was applied.</div></div><div><h3>Results</h3><div>Ninety-one out of 112 trial participants were included. Neither attachment anxiety nor attachment avoidance independently affected the treatment outcome. However, in a categorical approach, fearful patients (i.e., combined high anxiety and high avoidance) had a less favourable outcome (β = 9.98, 95 % CI: 4.05; 15.92, <em>p</em> = 0.001) than nonfearful patients. Insecure attachment did not moderate the superior effect of GAIN on PCS compared with EUC.</div></div><div><h3>Conclusion</h3><div>This study provided weak support for an association between insecure attachment and the outcome of an early intervention against long-lasting PCS in young persons after a concussion. However, patients with fearful attachment may represent a more vulnerable subgroup. Further research is needed to explore if attachment-informed intervention may enhance treatment prospects.</div></div>","PeriodicalId":50074,"journal":{"name":"Journal of Psychosomatic Research","volume":"199 ","pages":"Article 112428"},"PeriodicalIF":3.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}