Pub Date : 2025-11-21DOI: 10.1016/j.burns.2025.107806
Min Zhang , Xingyi Yang
{"title":"Comments on: \"Admission lymphopenia predicts risk of pneumonia and AKI in hospitalized burn injuries\"","authors":"Min Zhang , Xingyi Yang","doi":"10.1016/j.burns.2025.107806","DOIUrl":"10.1016/j.burns.2025.107806","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107806"},"PeriodicalIF":2.9,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.burns.2025.107801
Mahta Moghaddam Ahmadi, Moein Moghaddam Ahmadi
{"title":"Comments on: \"Burn injury in obesity: Examination of the Burn Care Quality Platform’s (BCQP) available data on obese patients to determine burn-related outcomes\"","authors":"Mahta Moghaddam Ahmadi, Moein Moghaddam Ahmadi","doi":"10.1016/j.burns.2025.107801","DOIUrl":"10.1016/j.burns.2025.107801","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107801"},"PeriodicalIF":2.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As autografting is limited for severely burned patients due to a lack of healthy donor sites, tissue-engineered autologous skin substitutes have emerged as a promising alternative. Yet, challenges persist, particularly regarding production time. Since cell culture is influenced by multiple factors, identifying these factors is crucial for improving culture yields. This retrospective study aimed to identify factors affecting skin cell extraction yields.
Methods
Culture data (method used, etc.) and clinical data (medical history, etc.) from all available patient records over a 35-year-period were collected. 18 variables were assessed using XGBoost as a variable selection tool, before fitting mixed-effects multivariate linear modeling.
Results
As expected, age inversely correlated with keratinocyte and fibroblast extraction yields, decreasing by 0.048 × 106 cells/cm² per year (CI95 % = [-0.065;-0.031]) and 0.035 × 106 cells/cm² per year (CI95 % = [-0.050;-0.019]), respectively. Keratinocyte yield also rose by 0.936 × 106 cells/cm² (CI95 % = [0.175;1.697]) when hairs could be grasped during the epidermis-dermis separation. Conversely, fibroblast yield increased by 0.042 × 106 cells/cm² per day post-burn (CI95 % = [0.007;0.076]) and by 0.019 × 106 cells/cm² per percentage of TBSA burned (CI95 % = [0.002;0.036]).
Conclusions
This findings provide valuable insights into factors influencing skin cell extraction yields, which may help optimize skin biopsy parameters, ultimately improving production efficiency.
{"title":"Factors affecting skin keratinocyte and fibroblast extraction yields for the production of living skin substitutes to treat severely burned patients","authors":"Ludivine Dubourget , Danielle Larouche , Sergio Cortez Ghio , Véronique J. Moulin , Chanel Beaudoin-Cloutier , Lucie Germain","doi":"10.1016/j.burns.2025.107805","DOIUrl":"10.1016/j.burns.2025.107805","url":null,"abstract":"<div><h3>Backgrounds</h3><div>As autografting is limited for severely burned patients due to a lack of healthy donor sites, tissue-engineered autologous skin substitutes have emerged as a promising alternative. Yet, challenges persist, particularly regarding production time. Since cell culture is influenced by multiple factors, identifying these factors is crucial for improving culture yields. This retrospective study aimed to identify factors affecting skin cell extraction yields.</div></div><div><h3>Methods</h3><div>Culture data (method used, etc.) and clinical data (medical history, etc.) from all available patient records over a 35-year-period were collected. 18 variables were assessed using XGBoost as a variable selection tool, before fitting mixed-effects multivariate linear modeling.</div></div><div><h3>Results</h3><div>As expected, age inversely correlated with keratinocyte and fibroblast extraction yields, decreasing by 0.048 × 10<sup>6</sup> cells/cm² per year (CI<sub>95 %</sub> = [-0.065;-0.031]) and 0.035 × 10<sup>6</sup> cells/cm² per year (CI<sub>95 %</sub> = [-0.050;-0.019]), respectively. Keratinocyte yield also rose by 0.936 × 10<sup>6</sup> cells/cm² (CI<sub>95 %</sub> = [0.175;1.697]) when hairs could be grasped during the epidermis-dermis separation. Conversely, fibroblast yield increased by 0.042 × 10<sup>6</sup> cells/cm² per day post-burn (CI<sub>95 %</sub> = [0.007;0.076]) and by 0.019 × 10<sup>6</sup> cells/cm² per percentage of TBSA burned (CI<sub>95 %</sub> = [0.002;0.036]).</div></div><div><h3>Conclusions</h3><div>This findings provide valuable insights into factors influencing skin cell extraction yields, which may help optimize skin biopsy parameters, ultimately improving production efficiency.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107805"},"PeriodicalIF":2.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.burns.2025.107803
Wolfram Heitzmann , Mitja Mossing , Maria von Kohout , Yasser Alhujaili , Jan Akkan , Paul Christian Fuchs , Rolf Lefering , Jennifer Lynn Schiefer
Recent advances in burn care have highlighted the benefits of enzymatic debridement in reducing long-term scarring by preserving viable dermal structures. Nexobrid®, a bromelain-based enzymatic debridement agent, has become an established treatment modality for deep-dermal burns, particularly of the hand, due to its selective action and tissue-sparing properties. After debridement, the choice of dressing critically influences inflammation, re-epithelialization, and ultimately scar quality and skin function. In clinical practice, Suprathel®, a synthetic copolymer membrane, and Jelonet®, a paraffin-impregnated gauze, are widely used. While Suprathel® offers improved pain control and patient comfort, Jelonet® remains a cost-effective standard.
Building on our previous intra-individual trial, which showed similar healing times but greater patient comfort with Suprathel®, this planned single-center, prospective long-term follow-up aims to address the lack of data on long-term scar quality and skin barrier function after enzymatic debridement. It includes the same 23 patients with deep-dermal hand burns who had received wound coverage with both Suprathel® and Jelonet® on comparable wound areas, assessed at 3, 6, and 12 months using objective instruments (Cutometer®, Mexameter®, Tewameter®, O2C®) and subjective scales (Vancouver Scar Scale, Patient and Observer Scar Assessment Scale).
Both dressings resulted in favorable and largely comparable scar outcomes over 12 months, with no significant differences in elasticity, perfusion, or overall clinical scar appearance. Subtle yet statistically significant differences in transepidermal water loss (p < 0.01) and pigmentation (p < 0.01) indicated a trend toward enhanced epidermal barrier restoration and reduced hypopigmentation in Suprathel®-treated areas, although these effects did not translate into perceptible clinical advantages.
These results confirm that both Suprathel® and Jelonet® are effective options for post-enzymatic debridement wound coverage, showing comparable long-term scar outcomes. The choice may reasonably depend on clinical workflow and dressing-management preferences, with Suprathel® remaining the standard in our burn center due to its reduced frequency of dressing changes.
{"title":"Long-term skin quality and scar formation after enzymatic debridement of deep-dermal burn wounds: A follow-up comparative study of Suprathel® and Jelonet®","authors":"Wolfram Heitzmann , Mitja Mossing , Maria von Kohout , Yasser Alhujaili , Jan Akkan , Paul Christian Fuchs , Rolf Lefering , Jennifer Lynn Schiefer","doi":"10.1016/j.burns.2025.107803","DOIUrl":"10.1016/j.burns.2025.107803","url":null,"abstract":"<div><div>Recent advances in burn care have highlighted the benefits of enzymatic debridement in reducing long-term scarring by preserving viable dermal structures. Nexobrid®, a bromelain-based enzymatic debridement agent, has become an established treatment modality for deep-dermal burns, particularly of the hand, due to its selective action and tissue-sparing properties. After debridement, the choice of dressing critically influences inflammation, re-epithelialization, and ultimately scar quality and skin function. In clinical practice, Suprathel®, a synthetic copolymer membrane, and Jelonet®, a paraffin-impregnated gauze, are widely used. While Suprathel® offers improved pain control and patient comfort, Jelonet® remains a cost-effective standard.</div><div>Building on our previous intra-individual trial, which showed similar healing times but greater patient comfort with Suprathel®, this planned single-center, prospective long-term follow-up aims to address the lack of data on long-term scar quality and skin barrier function after enzymatic debridement. It includes the same 23 patients with deep-dermal hand burns who had received wound coverage with both Suprathel® and Jelonet® on comparable wound areas, assessed at 3, 6, and 12 months using objective instruments (Cutometer®, Mexameter®, Tewameter®, O2C®) and subjective scales (Vancouver Scar Scale, Patient and Observer Scar Assessment Scale).</div><div>Both dressings resulted in favorable and largely comparable scar outcomes over 12 months, with no significant differences in elasticity, perfusion, or overall clinical scar appearance. Subtle yet statistically significant differences in transepidermal water loss (p < 0.01) and pigmentation (p < 0.01) indicated a trend toward enhanced epidermal barrier restoration and reduced hypopigmentation in Suprathel®-treated areas, although these effects did not translate into perceptible clinical advantages.</div><div>These results confirm that both Suprathel® and Jelonet® are effective options for post-enzymatic debridement wound coverage, showing comparable long-term scar outcomes. The choice may reasonably depend on clinical workflow and dressing-management preferences, with Suprathel® remaining the standard in our burn center due to its reduced frequency of dressing changes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107803"},"PeriodicalIF":2.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.burns.2025.107802
Nicholas D. Soulakis , Caroline Hensing , Annabelle Shaffer , David Gonzalez-Velez , Ashley A. Peters , Nathan Pecoraro , Paul M. Arnold
Introduction
Burn injuries cause significant morbidity and mortality. By better understanding the epidemiology and seasonality of such injuries, burn education and prevention efforts can be improved. The purpose of this investigation is to provide an update to the epidemiology of burn injuries in the United States (US).
Methods
This retrospective study analyzes data from the National Electronic Injury Surveillance System (NEISS) from 2014 to 2023. The NEISS collects data on emergency department visits from approximately 100 hospitals throughout the US. Data were analyzed using R version 4.4.3. to calculate annual burn estimates, injury rates, frequencies and acute periods of increased incidence.
Results
Between 2014 and 2023, emergency departments in the US treated an average of 206,856 burn injuries annually. These injuries occurred mainly in the home (66.8 %) and in males (53.1 %), with a peak incidence in children under 5 (20.6 %). This study found no significant increasing or decreasing trends in incidence over time; however, burn injury incidence and associated products fluctuated based on season, with an increased incidence occurring around July 4th.
Conclusion
Burn injuries significantly affect the US population. Public health and primary care workers may utilize information provided by this study to better target patient education on burn injury prevention.
{"title":"Epidemiology of emergency department visits for burn injuries in the United States, 2014–2023","authors":"Nicholas D. Soulakis , Caroline Hensing , Annabelle Shaffer , David Gonzalez-Velez , Ashley A. Peters , Nathan Pecoraro , Paul M. Arnold","doi":"10.1016/j.burns.2025.107802","DOIUrl":"10.1016/j.burns.2025.107802","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries cause significant morbidity and mortality. By better understanding the epidemiology and seasonality of such injuries, burn education and prevention efforts can be improved. The purpose of this investigation is to provide an update to the epidemiology of burn injuries in the United States (US).</div></div><div><h3>Methods</h3><div>This retrospective study analyzes data from the National Electronic Injury Surveillance System (NEISS) from 2014 to 2023. The NEISS collects data on emergency department visits from approximately 100 hospitals throughout the US. Data were analyzed using R version 4.4.3. to calculate annual burn estimates, injury rates, frequencies and acute periods of increased incidence.</div></div><div><h3>Results</h3><div>Between 2014 and 2023, emergency departments in the US treated an average of 206,856 burn injuries annually. These injuries occurred mainly in the home (66.8 %) and in males (53.1 %), with a peak incidence in children under 5 (20.6 %). This study found no significant increasing or decreasing trends in incidence over time; however, burn injury incidence and associated products fluctuated based on season, with an increased incidence occurring around July 4th.</div></div><div><h3>Conclusion</h3><div>Burn injuries significantly affect the US population. Public health and primary care workers may utilize information provided by this study to better target patient education on burn injury prevention.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107802"},"PeriodicalIF":2.9,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.burns.2025.107799
Shujun Qiu, Mingxian Chen
{"title":"Comments on: \"Background pain, procedural pain, and optimism are associated with post-discharge pain in burn survivors\"","authors":"Shujun Qiu, Mingxian Chen","doi":"10.1016/j.burns.2025.107799","DOIUrl":"10.1016/j.burns.2025.107799","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107799"},"PeriodicalIF":2.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.burns.2025.107781
Leopoldo C. Cancio, Kaitlin A. Pruskowski
{"title":"Historical note: The research strategy that halved postburn mortality","authors":"Leopoldo C. Cancio, Kaitlin A. Pruskowski","doi":"10.1016/j.burns.2025.107781","DOIUrl":"10.1016/j.burns.2025.107781","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107781"},"PeriodicalIF":2.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-19DOI: 10.1016/j.burns.2025.107788
Peng Han, Jie Zhang, Yunpeng Ma
Background
The pathogenesis of keloids is still unclear and effective biomarkers are lacking. Therefore, it is urgent to find clinically effective biomarkers and study their regulatory mechanisms.
Methods
Candidate genes were screened by amplifying RNA methylation-related gene modules by weighted correlation network analysis and intersecting them with differentially expressed genes in the GSE145725 dataset. After Mendelian randomisation, machine learning and gene expression validation, keloid prediction models were constructed. Subsequently, genomic enrichment analysis, immune infiltration, GeneMANIA analysis, molecular network and drug prediction were performed, and biomarker function was explored using single-cell datasets. Finally, biomarker expression in clinical samples was validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR).
Results
A total of two biomarkers (PEAR1 and MAPKAPK3) were identified and the disease prediction model performed well. They were mainly involved in the proteasomal and ribosomal pathways and were associated with myeloid dendritic cells and resting T CD4 + memory cells. In addition, fibroblasts were identified as key cells expressing PEAR1 and MAPKAPK3. RT-qPCR confirmed that the expression of both biomarkers was downregulated in the keloid group, consistent with the results of differential expression analysis.
Conclusion
This study suggests that PEAR1 and MAPKAPK3 may contribute to keloid formation and provides insights for subsequent functional studies.
{"title":"Uncovering and validating biomarkers associated with RNA methylation modifications in keloids: Insights from transcriptomic and Mendelian randomization analyses","authors":"Peng Han, Jie Zhang, Yunpeng Ma","doi":"10.1016/j.burns.2025.107788","DOIUrl":"10.1016/j.burns.2025.107788","url":null,"abstract":"<div><h3>Background</h3><div>The pathogenesis of keloids is still unclear and effective biomarkers are lacking. Therefore, it is urgent to find clinically effective biomarkers and study their regulatory mechanisms.</div></div><div><h3>Methods</h3><div>Candidate genes were screened by amplifying RNA methylation-related gene modules by weighted correlation network analysis and intersecting them with differentially expressed genes in the GSE145725 dataset. After Mendelian randomisation, machine learning and gene expression validation, keloid prediction models were constructed. Subsequently, genomic enrichment analysis, immune infiltration, GeneMANIA analysis, molecular network and drug prediction were performed, and biomarker function was explored using single-cell datasets. Finally, biomarker expression in clinical samples was validated by reverse transcription quantitative polymerase chain reaction (RT-qPCR).</div></div><div><h3>Results</h3><div>A total of two biomarkers (PEAR1 and MAPKAPK3) were identified and the disease prediction model performed well. They were mainly involved in the proteasomal and ribosomal pathways and were associated with myeloid dendritic cells and resting T CD4 + memory cells. In addition, fibroblasts were identified as key cells expressing PEAR1 and MAPKAPK3. RT-qPCR confirmed that the expression of both biomarkers was downregulated in the keloid group, consistent with the results of differential expression analysis.</div></div><div><h3>Conclusion</h3><div>This study suggests that PEAR1 and MAPKAPK3 may contribute to keloid formation and provides insights for subsequent functional studies.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107788"},"PeriodicalIF":2.9,"publicationDate":"2025-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burn survivors can experience overlapping symptoms; identifying clusters may improve care. This study examined chronic symptom clusters six months post-burn and their predictors and psychosocial impacts.
Methods
Data from the Burn Model System (2015–2022) were analyzed using factor analysis of post-burn symptoms. Linear regression assessed associations between factor scores and psychosocial outcomes.
Results
The sample included 405 patients (66 % male; mean age 45.4; median burn size 14 % TBSA; 60.2 % fire/flame). A three-factor solution was identified: (1) Psychological distress (28 % variance) with high loadings for anxiety and depression, moderate for sleep disturbance; (2) Pain-related symptoms (22 %) with high pain interference and intensity, moderate fatigue; (3) Itch-related symptoms (16 %) with high itch interference, moderate itch intensity. Rehabilitation days were associated with all factors; surgeries with Factors 1 and 2. Women scored higher on Factor 1, while %TBSA predicted Factor 3. Higher Factor 1 scores were linked to poorer mental health, greater PTSD burden, and lower life satisfaction and higher Factor 2 scores to worse physical and mental health.
Conclusion
At six months post-burn, symptoms clustered into psychological distress, pain, and itch factors. Pain and distress, but not itch, were associated with poorer physical, mental, and social functioning.
{"title":"Pain, itch, and psychological distress symptom clusters in burn survivors: A factor analysis","authors":"Lynn Nakad , Arushi Biswas , Jeannie-Marie Leoutsakos , Rachel Kornhaber , Michelle Cleary , Julie A. Caffrey , Sheera F. Lerman","doi":"10.1016/j.burns.2025.107787","DOIUrl":"10.1016/j.burns.2025.107787","url":null,"abstract":"<div><h3>Background</h3><div>Burn survivors can experience overlapping symptoms; identifying clusters may improve care. This study examined chronic symptom clusters six months post-burn and their predictors and psychosocial impacts.</div></div><div><h3>Methods</h3><div>Data from the Burn Model System (2015–2022) were analyzed using factor analysis of post-burn symptoms. Linear regression assessed associations between factor scores and psychosocial outcomes.</div></div><div><h3>Results</h3><div>The sample included 405 patients (66 % male; mean age 45.4; median burn size 14 % TBSA; 60.2 % fire/flame). A three-factor solution was identified: (1) Psychological distress (28 % variance) with high loadings for anxiety and depression, moderate for sleep disturbance; (2) Pain-related symptoms (22 %) with high pain interference and intensity, moderate fatigue; (3) Itch-related symptoms (16 %) with high itch interference, moderate itch intensity. Rehabilitation days were associated with all factors; surgeries with Factors 1 and 2. Women scored higher on Factor 1, while %TBSA predicted Factor 3. Higher Factor 1 scores were linked to poorer mental health, greater PTSD burden, and lower life satisfaction and higher Factor 2 scores to worse physical and mental health.</div></div><div><h3>Conclusion</h3><div>At six months post-burn, symptoms clustered into psychological distress, pain, and itch factors. Pain and distress, but not itch, were associated with poorer physical, mental, and social functioning.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107787"},"PeriodicalIF":2.9,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.burns.2025.107785
Tobias Niederegger , Thomas Schaschinger , Jule Brandt , Leonard Knoedler , Samuel Knoedler , Alen Palackic , Felix J. Klimitz , Dorothea Noll , Patrick Most , Julia Ritterhoff , Adriana C. Panayi , Gabriel Hundeshagen
Severe burns induce a hypermetabolic and inflammatory state, impairing wound healing and contributing to long-term morbidity. Fibroblast growth factor 21 (FGF-21), a metabolic hormone regulating lipid oxidation, glucose uptake, and mitochondrial homeostasis, has emerged as a potential biomarker and therapeutic modulator in critical illness.
This systematic review followed PRISMA 2020 guidelines and assessed seven studies (2015–2024) published until April 2025. Clinical, in vivo, and in vitro investigations were included. Methodological quality was evaluated using the Level of Evidence, Newcastle-Ottawa Scale, and the SYRCLE Risk of Bias tool.
In our study, FGF-21 was commonly upregulated following burn injury and was associated with hypermetabolism, adipose tissue browning, mitochondrial stress, and systemic inflammation. Nutritional interventions, including hydrolyzed collagen and omega-3 fatty acids, reduced FGF-21 levels, improved wound healing, and attenuated inflammatory responses. Preclinical models demonstrated that administration of exogenous FGF-21 enhanced re-epithelialization, angiogenesis, mitochondrial function, and anti-inflammatory signaling pathways. Conversely, chronically elevated endogenous FGF-21 levels were consistently linked to metabolic exhaustion, liver dysfunction, and impaired recovery.
Overall, FGF-21 may be a promising diagnostic and therapeutic target in burn care. Its clinical relevance and long-term effects require further investigation for successful integration into clinical practice.
{"title":"The burn repair molecule? Evaluating FGF-21 in thermal injury – A systematic review","authors":"Tobias Niederegger , Thomas Schaschinger , Jule Brandt , Leonard Knoedler , Samuel Knoedler , Alen Palackic , Felix J. Klimitz , Dorothea Noll , Patrick Most , Julia Ritterhoff , Adriana C. Panayi , Gabriel Hundeshagen","doi":"10.1016/j.burns.2025.107785","DOIUrl":"10.1016/j.burns.2025.107785","url":null,"abstract":"<div><div>Severe burns induce a hypermetabolic and inflammatory state, impairing wound healing and contributing to long-term morbidity. Fibroblast growth factor 21 (FGF-21), a metabolic hormone regulating lipid oxidation, glucose uptake, and mitochondrial homeostasis, has emerged as a potential biomarker and therapeutic modulator in critical illness.</div><div>This systematic review followed PRISMA 2020 guidelines and assessed seven studies (2015–2024) published until April 2025. Clinical, in vivo, and in vitro investigations were included. Methodological quality was evaluated using the Level of Evidence, Newcastle-Ottawa Scale, and the SYRCLE Risk of Bias tool.</div><div>In our study, FGF-21 was commonly upregulated following burn injury and was associated with hypermetabolism, adipose tissue browning, mitochondrial stress, and systemic inflammation. Nutritional interventions, including hydrolyzed collagen and omega-3 fatty acids, reduced FGF-21 levels, improved wound healing, and attenuated inflammatory responses. Preclinical models demonstrated that administration of exogenous FGF-21 enhanced re-epithelialization, angiogenesis, mitochondrial function, and anti-inflammatory signaling pathways. Conversely, chronically elevated endogenous FGF-21 levels were consistently linked to metabolic exhaustion, liver dysfunction, and impaired recovery.</div><div>Overall, FGF-21 may be a promising diagnostic and therapeutic target in burn care. Its clinical relevance and long-term effects require further investigation for successful integration into clinical practice.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107785"},"PeriodicalIF":2.9,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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