Burns最新文献

{"title":"Spanish translation, cultural, and content validation of the Mouth Impairment and Disability Assessment in a prospective, longitudinal evaluation of pediatric patients with facial burn injuries","authors":"Bernadette Nedelec ,&nbsp;Ingrid Parry ,&nbsp;Clarissa Ochoa ,&nbsp;David G. Greenhalgh ,&nbsp;Zoë Edger-Lacoursière ,&nbsp;Jakub Sawicki","doi":"10.1016/j.burns.2025.107775","DOIUrl":"10.1016/j.burns.2025.107775","url":null,"abstract":"<div><div>The Mouth Impairment and Disability Assessment (MIDA) was developed to provide clinicians with an outcome measure that thoroughly and objectively evaluates the impairment and disabilities associated with burn injuries of the face involving the mouth. However, thus far, it is only available in English and French-Canadian and has not been used with pediatric burn survivors. Additionally, there is limited longitudinal outcome data describing the recovery trajectory associated with burn injuries of the mouth. Thus, the purpose of this study was to translate the MIDA into Spanish, validate the content with the pediatric burn survivor population who have sustained a burn injury involving their mouth, and prospectively collect data to document the recovery profile and examine the psychometric properties.</div></div><div><h3>Methods</h3><div>This was a prospective, observational case series of pediatric burn survivors. Prior to commencing patient recruitment, a forward-backward translation and cultural adaptation process was undertaken to create a Spanish version of the MIDA. English- and Spanish-speaking pediatric burn survivors who met the inclusion criteria and had signed the informed consent were evaluated using the MIDA at approximately one month, three months, six months, and 12 months post-burn. Individual and subscale summary data from the MIDA are reported. Construct validity was assessed by examining the correlations between MIDA subscale scores at baseline and measures of vertical and horizontal mouth opening.</div></div><div><h3>Results</h3><div>Sixteen predominantly Hispanic (75 %) pediatric burn survivors were evaluated approximately one-month post-burn, eleven were evaluated at three and six months, and nine at twelve months. The majority were male (62.5 %) with a mean age of 10.4 years old and mean total body surface area burn of 33.3 %. The median number of surgeries was two, with a median of one involving the face, mouth, or neck. Content validity was confirmed through cognitive debriefing and self-reported difficulties with all items within the measure at various points across time. The recovery profile varied across time, with many reporting a reduction in function between one and three months, most reporting an improvement by six or twelve months, but some continuing to experience extreme difficulty or dissatisfaction at twelve months.</div></div><div><h3>Discussion</h3><div>The Spanish version of the MIDA can now be used with the burn survivor population to evaluate the outcome of face and neck burns that may result in mouth impairment and disability. In addition, it proved to be a valid measure for quantifying the challenges that arise for pediatric burn survivors. There is a need for future research to investigate which treatment interventions optimize long-term outcomes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107775"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative power of organ-specific SOFA assessment in burn sepsis: A temporal biomarker analysis","authors":"Hang Su ,&nbsp;Bo Yuan ,&nbsp;Yan Liu ,&nbsp;Wenjing Xi ,&nbsp;Liang Qiao","doi":"10.1016/j.burns.2025.107771","DOIUrl":"10.1016/j.burns.2025.107771","url":null,"abstract":"<div><h3>Background</h3><div>Severe burn patients face diagnostic challenges in distinguishing sepsis from systemic inflammation using Sepsis-3 criteria. Current Sequential Organ Failure Assessment (SOFA) validation studies focus on composite scores, neglecting subsystem-level analysis in burn-specific pathophysiology.</div></div><div><h3>Methods</h3><div>This retrospective cohort study analyzed 55 severe burn patients (TBSA&gt;30 %) from a Chinese burn center (2021–2022), comparing 19 sepsis cases with 36 controls. We analyzed SOFA subsystems and biomarkers (creatinine, platelet count, NT-proBNP, and PCT) during both the early phase (days 1 and 3 post-burn) and the late phase (after day 3 post-burn), performed TBSA-adjusted logistic regression, and constructed a nomogram.</div></div><div><h3>Results</h3><div>Cardiovascular (84.2 % vs 2.8 %, p &lt; 0.001), renal (31.6 % vs 0 %, p &lt; 0.001), and coagulation (42.1 % vs 5.6 %, p &lt; 0.001) subsystems showed superior diagnostic specificity. Platelet trajectories revealed critical divergence at day 3 (septic: 66 vs control: 120 ×10⁹/L, p &lt; 0.001), while creatinine elevation persisted across phases (day 1: 100 vs 62 μmol/L, p &lt; 0.001, day 3: 84 vs 65 μmol/L, and late phase: 118 vs 58μmol/L, p &lt; 0.001). PCT demonstrated isolated diagnostic utility confined to the late phase (6.12 vs 0.55 μg/L, p &lt; 0.001). Day 3 platelet count, late-phase creatinine, and PCT were incorporated into the nomogram, which achieved an AUC of 0.930 in ROC analysis.</div></div><div><h3>Conclusion</h3><div>Subsystem-specific SOFA analysis identifies creatinine elevation and thrombocytopenia as key sepsis indicators in burns. Serial platelet and creatinine monitoring from day 3 post-injury enhances early detection, while PCT demonstrates diagnostic utility only in the late phase. A clinically applicable nomogram was developed to predict sepsis risk. These findings suggest that these specific organ systems are the principal contributors to the SOFA score in burn-related sepsis.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107771"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: \"Admission lymphopenia predicts risk of pneumonia and AKI in hospitalized burn injuries\"","authors":"Min Zhang ,&nbsp;Xingyi Yang","doi":"10.1016/j.burns.2025.107806","DOIUrl":"10.1016/j.burns.2025.107806","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107806"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145614204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we predict mortality, length of stay, and time taken to heal at the point of admission in burn patients?","authors":"Olivia Antoinette Smith ,&nbsp;Ascanio Tridente ,&nbsp;Sankhya Kapil Sen","doi":"10.1016/j.burns.2025.107779","DOIUrl":"10.1016/j.burns.2025.107779","url":null,"abstract":"<div><h3>Background</h3><div>Burn injuries may be complex, life-changing and life-threatening. Knowing the factors that contribute to unfavourable outcomes, particularly mortality, is crucial so that they can be assessed and addressed. Well-recognised contributors to adverse outcomes in burn patients include age, burn size, revised Baux score, and inhalation injury. Less well described, but increasingly reported, is frailty status. Here we aim to expand the current literature by adjusting for confounders not previously investigated. This is important particularly with an increasing emphasis on frailty assessment in acute care.</div></div><div><h3>Methods</h3><div>A retrospective analysis of adult burn patients who required admission was conducted at a single burns unit in the United Kingdom from 2019 to 2024. The Rockwood Clinical Frailty Scale (CFS) was used to assess an individual’s frailty on a scale of 1 (very fit) to 9 (terminally ill). Univariate and multi-variate linear and logistic regression analyses assessed associations between various predictors, including revised Baux score and frailty (as a potential prognostic factor), and hospital mortality, length of stay, and time taken to heal.</div></div><div><h3>Results</h3><div>Our study included 1451 adult patients. Adjusting for age, sex, burn size, inhalation injury, and revised Baux score, frailty was significantly associated with increased mortality (OR 3, CI 1.84 – 4.88, p &lt; 0.001), length of hospital stay (LOS, <em>b</em> 2.03, 95 % CI 1.27 – 2.78, p &lt; 0.001), and time taken to heal (<em>b</em> 4.5, 95 % CI 1.75 – 7.3, p = 0.001). Other significant predictors of mortality were %TBSA (OR per % increase 1.06, 95 % CI 1.03–1.1, p &lt; 0.001) and revised Baux (OR per 1 point increase 1.06, 95 % CI 1.03 – 1.1, p = 0.001). Burn %TBSA was also predictive of LOS (β per 1 % increase 0.35, 95 % CI 0.24 – 0.47, p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Our findings suggest that 1) age, %TBSA, revised Baux score, and frailty are independently associated with mortality in burn injured patients; 2) frailty score and the % TBSA are independent predictors of increased length of hospital stay; and 3) frailty is an independent predictor of prolonged burn wound healing time. Further validation in more severe burn cohorts and multi-centre populations is needed before strong clinical recommendations can be made.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107779"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145670566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: \"Burn injury in obesity: Examination of the Burn Care Quality Platform’s (BCQP) available data on obese patients to determine burn-related outcomes\"","authors":"Mahta Moghaddam Ahmadi,&nbsp;Moein Moghaddam Ahmadi","doi":"10.1016/j.burns.2025.107801","DOIUrl":"10.1016/j.burns.2025.107801","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107801"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burn repair molecule? Evaluating FGF-21 in thermal injury – A systematic review","authors":"Tobias Niederegger ,&nbsp;Thomas Schaschinger ,&nbsp;Jule Brandt ,&nbsp;Leonard Knoedler ,&nbsp;Samuel Knoedler ,&nbsp;Alen Palackic ,&nbsp;Felix J. Klimitz ,&nbsp;Dorothea Noll ,&nbsp;Patrick Most ,&nbsp;Julia Ritterhoff ,&nbsp;Adriana C. Panayi ,&nbsp;Gabriel Hundeshagen","doi":"10.1016/j.burns.2025.107785","DOIUrl":"10.1016/j.burns.2025.107785","url":null,"abstract":"<div><div>Severe burns induce a hypermetabolic and inflammatory state, impairing wound healing and contributing to long-term morbidity. Fibroblast growth factor 21 (FGF-21), a metabolic hormone regulating lipid oxidation, glucose uptake, and mitochondrial homeostasis, has emerged as a potential biomarker and therapeutic modulator in critical illness.</div><div>This systematic review followed PRISMA 2020 guidelines and assessed seven studies (2015–2024) published until April 2025. Clinical, in vivo, and in vitro investigations were included. Methodological quality was evaluated using the Level of Evidence, Newcastle-Ottawa Scale, and the SYRCLE Risk of Bias tool.</div><div>In our study, FGF-21 was commonly upregulated following burn injury and was associated with hypermetabolism, adipose tissue browning, mitochondrial stress, and systemic inflammation. Nutritional interventions, including hydrolyzed collagen and omega-3 fatty acids, reduced FGF-21 levels, improved wound healing, and attenuated inflammatory responses. Preclinical models demonstrated that administration of exogenous FGF-21 enhanced re-epithelialization, angiogenesis, mitochondrial function, and anti-inflammatory signaling pathways. Conversely, chronically elevated endogenous FGF-21 levels were consistently linked to metabolic exhaustion, liver dysfunction, and impaired recovery.</div><div>Overall, FGF-21 may be a promising diagnostic and therapeutic target in burn care. Its clinical relevance and long-term effects require further investigation for successful integration into clinical practice.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107785"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in burn size assessment: A systematic review of emerging technologies","authors":"Amy Woods ,&nbsp;Poh Tan,&nbsp;Tamara Mertz,&nbsp;Christopher J. Lewis","doi":"10.1016/j.burns.2025.107782","DOIUrl":"10.1016/j.burns.2025.107782","url":null,"abstract":"<div><h3>Background</h3><div>Accurate and reproducible assessment of total body surface area (TBSA) in burns is vital for guiding fluid resuscitation, triage, referral decisions, and overall clinical management. Traditional methods are widely used but prone to significant inter-rater variability and diagnostic inaccuracies.</div></div><div><h3>Objective</h3><div>This systematic review evaluates emerging technologies developed to improve TBSA estimation, focusing on diagnostic accuracy and inter-rater reliability.</div></div><div><h3>Methods</h3><div>A comprehensive search of EMBASE, MEDLINE (OVID), Web of Science, Scopus, PubMed and Cochrane Library databases was conducted. Studies assessing technological tools for TBSA estimation in both human and artificial burns were included. Primary outcomes were accuracy and reliability, while secondary outcomes included speed and user feedback. Study quality was appraised using the QUADAS-2 tool.</div></div><div><h3>Results</h3><div>Thirty-six studies were included: 3D programs (n = 7), mobile applications (n = 11), 3D stereophotogrammetry (n = 8), and machine learning models (n = 10). 3D stereophotogrammetry showed the highest accuracy (mean ICC = 0.988) and excellent inter-rater reliability (ICC = 0.989). 3D programs demonstrated good diagnostic performance and reduced variability. Mobile applications improved accuracy and consistency, particularly among non-specialists, and offered practical benefits in prehospital settings. Machine learning, though largely in experimental phases, demonstrated promising accuracy, with some models outperforming clinician estimates.</div></div><div><h3>Conclusion</h3><div>3D stereophotogrammetry provided more consistent and reliable estimates of TBSA, while mobile applications offered practical and scalable solutions. Early machine learning approaches showed potential but remain largely experimental. Overall, most studies were of low quality and methodologically heterogeneous; therefore, definitive conclusions cannot yet be drawn. Further high-quality, real-world research is required to validate accuracy and establish clinical utility.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107782"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: “Red blood cell transfusion risk factors and outcomes in burn patients: A retrospective cohort study”","authors":"Liying Jin,&nbsp;Xingyi Yang","doi":"10.1016/j.burns.2025.107814","DOIUrl":"10.1016/j.burns.2025.107814","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107814"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into the clinical condition of burn patients with venous catheters","authors":"Mohammad Hossein Sobhkhizi,&nbsp;Mozhdeh Mohammadghasemi,&nbsp;Negin Mohammadghasemi,&nbsp;Zahra Shahraki","doi":"10.1016/j.burns.2025.107749","DOIUrl":"10.1016/j.burns.2025.107749","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107749"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term skin quality and scar formation after enzymatic debridement of deep-dermal burn wounds: A follow-up comparative study of Suprathel® and Jelonet®","authors":"Wolfram Heitzmann ,&nbsp;Mitja Mossing ,&nbsp;Maria von Kohout ,&nbsp;Yasser Alhujaili ,&nbsp;Jan Akkan ,&nbsp;Paul Christian Fuchs ,&nbsp;Rolf Lefering ,&nbsp;Jennifer Lynn Schiefer","doi":"10.1016/j.burns.2025.107803","DOIUrl":"10.1016/j.burns.2025.107803","url":null,"abstract":"<div><div>Recent advances in burn care have highlighted the benefits of enzymatic debridement in reducing long-term scarring by preserving viable dermal structures. Nexobrid®, a bromelain-based enzymatic debridement agent, has become an established treatment modality for deep-dermal burns, particularly of the hand, due to its selective action and tissue-sparing properties. After debridement, the choice of dressing critically influences inflammation, re-epithelialization, and ultimately scar quality and skin function. In clinical practice, Suprathel®, a synthetic copolymer membrane, and Jelonet®, a paraffin-impregnated gauze, are widely used. While Suprathel® offers improved pain control and patient comfort, Jelonet® remains a cost-effective standard.</div><div>Building on our previous intra-individual trial, which showed similar healing times but greater patient comfort with Suprathel®, this planned single-center, prospective long-term follow-up aims to address the lack of data on long-term scar quality and skin barrier function after enzymatic debridement. It includes the same 23 patients with deep-dermal hand burns who had received wound coverage with both Suprathel® and Jelonet® on comparable wound areas, assessed at 3, 6, and 12 months using objective instruments (Cutometer®, Mexameter®, Tewameter®, O2C®) and subjective scales (Vancouver Scar Scale, Patient and Observer Scar Assessment Scale).</div><div>Both dressings resulted in favorable and largely comparable scar outcomes over 12 months, with no significant differences in elasticity, perfusion, or overall clinical scar appearance. Subtle yet statistically significant differences in transepidermal water loss (p &lt; 0.01) and pigmentation (p &lt; 0.01) indicated a trend toward enhanced epidermal barrier restoration and reduced hypopigmentation in Suprathel®-treated areas, although these effects did not translate into perceptible clinical advantages.</div><div>These results confirm that both Suprathel® and Jelonet® are effective options for post-enzymatic debridement wound coverage, showing comparable long-term scar outcomes. The choice may reasonably depend on clinical workflow and dressing-management preferences, with Suprathel® remaining the standard in our burn center due to its reduced frequency of dressing changes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 1","pages":"Article 107803"},"PeriodicalIF":2.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}