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Artificial intelligence and its contribution to overcome COVID-19 人工智能及其对抗击新冠肺炎的贡献
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330646
A. Chockalingam, V. Tyagi, R. Krishnan, Shehroz S. Khan, Sarath Chandar, M. Beg, V. Mahajan, Parasvil Patel, S. Mullapudi, N. Thakkar, Arrti Bhasin, A. Tyagi, B. Ye, Alex Mihailidis
Artificial intelligence (AI) has a great impact on our daily living and makes our lives more efficient and productive. Especially during the coronavirus disease (COVID-19) pandemic, AI has played a key role in response to the global health crisis. There has been a boom in AI innovation and its use since the pandemic. However, despite its widespread adoption and great potential, most people have little knowledge of AI concepts and realization of its potential. The objective of this white paper is to communicate the importance of AI and its benefits to society. The report covers AI applications in six different topics from medicine (AI deployment in clinical settings, imaging and diagnostics, and acceleration of drug discovery) to more social aspects (support older adults in long-term care homes, and AI in supporting small and medium enterprises. The report ends with nine steps to consider for moving forward with AI implementation during and post pandemic period. These include legal and ethical data collection and storage, greater data access, multidisciplinary collaboration, and policy reform.
人工智能(AI)对我们的日常生活产生了巨大的影响,使我们的生活更加高效和富有成效。特别是在2019冠状病毒病(COVID-19)大流行期间,人工智能在应对全球卫生危机方面发挥了关键作用。自疫情以来,人工智能的创新和使用出现了蓬勃发展。然而,尽管人工智能被广泛采用,潜力巨大,但大多数人对人工智能的概念知之甚少,也没有意识到它的潜力。本白皮书的目的是传达人工智能的重要性及其对社会的好处。该报告涵盖了人工智能在六个不同主题中的应用,从医学(人工智能在临床环境中的部署、成像和诊断,以及加速药物发现)到更多的社会方面(支持长期护养院的老年人,以及人工智能在支持中小企业方面的应用)。报告最后提出了在大流行期间和大流行后推进人工智能实施的九项考虑步骤。这些挑战包括法律和伦理数据的收集和存储、更广泛的数据获取、多学科合作和政策改革。
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引用次数: 0
Voice support system using deep learning approaches for unilateral vocal cord paralyzed patients 基于深度学习方法的单侧声带麻痹患者语音支持系统
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330655
Chocko Valliappa, R. S. Sabeenian, M. Paramasivam, Eldho Paul, K. Manju, R. Pragadeesh
Vocal cord paralysis is a common problem faced by individuals, where the vocal cord fails to reverberate to produce sound waves. As a result, they are unable to speak out as they were speaking before. The proposed method is designed for aiding unilateral paralyzed peoples whose vocal cord fails to give the desired reverberations. The proposed system consists of voice-to-text and text-to-voice conversions. The voice of the paralyzed person is artificially reproduced by training a deep neural network with the unaffected voice of the patient. The confidence of the predicted output is improved by introducing voice-to-text conversion block along with the deep neural network. The performance metrics reveals the effectiveness of the proposed algorithm to reproduce natural sound. The similarity index is also high compared to that of other state-of-the-art techniques.
声带麻痹是个体面临的一个常见问题,声带无法产生回声来产生声波。因此,他们无法像以前那样畅所欲言。所提出的方法是为了帮助单侧瘫痪的人,他们的声带无法产生所需的回声。所提出的系统包括语音到文本和文本到语音的转换。瘫痪者的声音是通过用患者未受影响的声音训练深度神经网络来人工复制的。通过引入语音到文本转换块以及深度神经网络,提高了预测输出的置信度。性能指标揭示了所提出的算法再现自然声音的有效性。与其他最先进的技术相比,相似性指数也很高。
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引用次数: 1
A novel machine learning-based video classification approach to detect pneumonia in COVID-19 patients using lung ultrasound 一种新的基于机器学习的视频分类方法用于检测新冠肺炎患者肺部超声肺炎
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330653
Deepa Krishnaswamy, Salehe Erfanian Ebadi, Seyed Ehsan Seyed Bolouri, D. Zonoobi, Russ Greiner, Nathaniel Meuser-Herr, J. Jaremko, J. Kapur, M. Noga, K. Punithakumar
Context: Efficiently diagnosing COVID-19-related pneumonia is of high clinical relevance. Point-of-care ultrasound allows detecting lung conditions via patterns of artifacts, such as clustered B-lines. Aims: The aim is to classify lung ultrasound videos into three categories: Normal (containing A-lines), interstitial abnormalities (B-lines), and confluent abnormalities (pleural effusion/consolidations) using a semi-automated approach. Settings and Design: This was a prospective observational study using 1530 videos in 300 patients presenting with clinical suspicion of COVID-19 pneumonia, where the data were collected and labeled by human experts versus machine learning. Subjects and Methods: Experts labeled each of the videos into one of the three categories. The labels were used to train a neural network to automatically perform the same classification. The proposed neural network uses a unique two-stream approach, one based on raw red-green-blue channel (RGB) input and the other consisting of velocity information. In this manner, both spatial and temporal ultrasound features can be captured. Statistical Analysis Used: A 5-fold cross-validation approach was utilized for the evaluation. Cohen's kappa and Gwet's AC1 metrics are calculated to measure the agreement with the human rater for the three categories. Cases are also divided into interstitial abnormalities (B-lines) and other (A-lines and confluent abnormalities) and precision-recall and receiver operating curve curves created. Results: This study demonstrated robustness in determining interstitial abnormalities, with a high F1 score of 0.86. For the human rater agreement for interstitial abnormalities versus the rest, the proposed method obtained a Gwet's AC1 metric of 0.88. Conclusions: The study demonstrates the use of a deep learning approach to classify artifacts contained in lung ultrasound videos in a robust manner.
背景:高效诊断新型冠状病毒肺炎具有很高的临床意义。即时超声可以通过伪影的模式来检测肺部状况,比如聚集的b线。目的:目的是使用半自动方法将肺超声视频分为三类:正常(含a线),间质异常(b线)和融合异常(胸腔积液/实变)。设置和设计:这是一项前瞻性观察性研究,使用了300名临床怀疑为COVID-19肺炎的患者的1530个视频,其中数据由人类专家与机器学习收集和标记。研究对象和方法:专家将每个视频分为三类之一。这些标签被用来训练神经网络来自动执行相同的分类。该神经网络采用一种独特的双流方法,一种基于原始红绿蓝通道(RGB)输入,另一种由速度信息组成。通过这种方式,可以捕获空间和时间超声特征。使用的统计分析:采用5重交叉验证方法进行评价。Cohen的kappa和Gwet的AC1指标是用来衡量与人类评分者在这三个类别上的一致程度的。病例也分为间质异常(b线)和其他(a线和合流异常),并绘制精确召回曲线和受者操作曲线。结果:本研究在确定间质异常方面具有稳健性,F1评分高达0.86。对于人类间质异常的一致性,该方法获得的Gwet的AC1度量为0.88。结论:该研究展示了使用深度学习方法以稳健的方式对肺超声视频中包含的伪影进行分类。
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引用次数: 2
Coronavirus disease 2019: The prospect for botanical drug's polymolecular approach 2019冠状病毒病:植物药多分子方法的展望
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330651
A. Boulet
Coronavirus disease 2019 (COVID-19) pandemic has caused the millions of deaths worldwide. Much of the mortality has been associated with a cytokine storm syndrome in patients admitted to the hospital with acute respiratory distress syndrome. Vast arrays of anti-inflammatory therapies are being explored to decrease the cytokine storm to save the lives. None of these therapies have demonstrated efficacy at all stages of the disease thus underlining its complexity. The current vaccine approach is challenged by the emerging virus variants. A multi-target approaches have been used with success for human immunodeficiency virus and some types of cancer. It has been recently proposed to use the same strategy for COVID-19. With their polymolecular structure, botanical drugs may offer an option within that strategy. Thykamine™, a novel botanical drug, with demonstrated anti-inflammatory, antioxidant, and immunomodulatory effects may become the part of the therapeutic arsenal against COVID-19.
2019冠状病毒病(新冠肺炎)大流行已导致全球数百万人死亡。大部分死亡与急性呼吸窘迫综合征患者的细胞因子风暴综合征有关。正在探索大量的抗炎疗法,以减少细胞因子风暴,挽救生命。这些疗法中没有一种在疾病的所有阶段都显示出疗效,从而突显了其复杂性。目前的疫苗方法受到新出现的病毒变种的挑战。多靶点方法已成功用于人类免疫缺陷病毒和某些类型的癌症。最近有人提议对新冠肺炎使用同样的策略。由于其多分子结构,植物药物可能在该策略中提供一种选择。Thykamine™, 一种新型植物药物,具有抗炎、抗氧化和免疫调节作用,可能成为对抗新冠肺炎的治疗武器库的一部分。
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引用次数: 0
Noncommunicable diseases in the age of pandemics 流行病时代的非传染性疾病
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330644
A. Chockalingam, S. Kalyanasundaram
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引用次数: 0
Modeling pandemics and vaccine and equity issues 模拟流行病、疫苗和公平问题
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330649
V. Murty, Brian T Schwartz, R. Dembo, J. Thakur, Arrti Bhasin, A. Chockalingam
We present some recent activity in Ontario on the mathematical modeling of COVID-19 and the development of optimal strategies for vaccine distribution that take into account equity issues.
我们介绍了安大略省最近在新冠肺炎数学模型和制定考虑公平问题的疫苗分配最佳策略方面的一些活动。
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引用次数: 0
Enveloped virus-like particles as a platform for vaccine development 包膜病毒样颗粒作为疫苗开发的平台
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330656
F. Diaz-Mitoma
Vaccination is the most effective approach in preventing and controlling the global public health threat of infectious diseases. Enveloped virus-like particles (eVLPs) offer advantages over other subunit vaccines because of their self-adjuvanting properties. Their optimal size and particulate structure activate antigen-presenting cells. The flexibility in manufacturing, applications, and advantages for preventing or treating disease are highlighted by the vaccine candidates described in this review. Previous preclinical and clinical studies demonstrated the immunogenicity of two eVLP vaccine candidates designed to protect against cytomegalovirus. The expression of viral envelope proteins in the eVLPs induces a robust neutralizing antibody response, which is considered a correlate of protection in many viral infections. VBI has developed two vaccine candidates against SARS CoV2, VBI-2902a, and VBI-2905a. Ongoing clinical development of these vaccine candidates will assess human safety and immunogenicity, after one or two doses in previously vaccinated and unvaccinated, individuals (NCT04773665).
疫苗接种是预防和控制传染病对全球公共卫生威胁的最有效方法。由于包膜病毒样颗粒(evlp)具有自我调节特性,因此与其他亚单位疫苗相比具有优势。它们的最佳尺寸和颗粒结构可以激活抗原呈递细胞。本文介绍的候选疫苗在制造、应用和预防或治疗疾病方面的灵活性和优势。先前的临床前和临床研究证明了两种eVLP候选疫苗的免疫原性,这些疫苗被设计用于预防巨细胞病毒。evlp中病毒包膜蛋白的表达诱导了强大的中和抗体反应,这被认为是许多病毒感染中保护的相关因素。VBI已经开发了两种针对SARS CoV2的候选疫苗,VBI-2902a和VBI-2905a。正在进行的这些候选疫苗的临床开发将在先前接种和未接种疫苗的个体中接种一剂或两剂后评估人体安全性和免疫原性(NCT04773665)。
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引用次数: 2
Vaccine distribution for COVID-19 and equity issues in India 新冠肺炎疫苗分配和印度的公平问题
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330658
J. Thakur, H. Kaur
India, being the biggest producer of drugs including vaccines, emerged as a major supplier of the coronavirus vaccines for most of the countries across the world during the COVID-19 pandemic. Two vaccines, Covishield and Covaxin, were given emergency use authorization by India's drugs regulator during initial phases. Under the guidance of the National Expert Group on Vaccine Administration for COVID-19, India started its national vaccination program against SARS-CoV-2 on January 16, 2021. CoWIN (COVID-19 Vaccine Intelligence Network) is playing a vital role in real-time monitoring of COVID-19 vaccination. Having a robust Universal Immunization Program and experience of the previous immunization campaigns are advantages for India's COVID-19 vaccination program. Under Vaccine Maitri initiative, India is providing vaccines to nations across the world to ensure vaccine equity. In India, vaccination is being done in a phased manner where priority is given to the health and other frontline workers, people with age >50 years and people with comorbidities and above 18 years. As per the current policy, center government is responsible for buying 75% of all vaccines made for use in India and will distribute it to states based on their populations, disease burdens, and number of people to be vaccinated. Remaining 25% vaccines are available to be procured by private hospitals. However, existing facilities seem to be unable to meet the increased demand, and the government is considering approval for other vaccines to be imported. The world, including India, is still fighting against COVID-19 and vaccine equity is very important to win against this pandemic.
印度是包括疫苗在内的最大药品生产国,在新冠肺炎大流行期间成为世界上大多数国家冠状病毒疫苗的主要供应国。Covishield和Covaxin两种疫苗在最初阶段获得了印度药品监管机构的紧急使用授权。在新冠肺炎疫苗管理国家专家组的指导下,印度于2021年1月16日启动了全国SARS-CoV-2疫苗接种计划。CoWIN(新冠肺炎疫苗情报网络)在新冠肺炎疫苗接种的实时监测中发挥着至关重要的作用。印度新冠肺炎疫苗接种计划的优势在于拥有强大的全民免疫计划和以往免疫运动的经验。根据疫苗Maitri倡议,印度正在向世界各国提供疫苗,以确保疫苗公平。在印度,疫苗接种正在分阶段进行,优先考虑卫生和其他一线工作人员、50岁以上人群以及患有合并症和18岁以上人群。根据目前的政策,中央政府负责购买印度75%的疫苗,并将根据各州的人口、疾病负担和接种人数将其分发给各州。其余25%的疫苗可由私立医院采购。然而,现有设施似乎无法满足日益增长的需求,政府正在考虑批准进口其他疫苗。包括印度在内的世界仍在与新冠肺炎作斗争,疫苗公平对于战胜这一流行病非常重要。
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引用次数: 1
Canada India Healthcare Summit 2021: Executive Overview 加拿大印度医疗保健峰会2021:执行概述
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330645
V. Lakshmanan, A. Chockalingam, S. Kalyanasundaram
The Canada India Health-care Summit 2021, (“CIHS 2021”), is the 3rd Summit, focusing on healthcare, organized by Canada India Foundation, as part of an ongoing series of thematic Canada India Forums, to highlight opportunities for collaboration between Canada and India in key strategic sectors and make public policy recommendations to the respective governments. The Federation of Indian Chambers of Commerce and Industry, Toronto Rehabilitation Institute – University Health Network and the Consulate General of India in Toronto were co-organizers of the Summit. CIHS 2021 was focused on three themes: (1) artificial intelligence and its contribution to overcome COVID-19, (2) biotechnology and its contribution to overcome COVID-19, and (3) pandemic responses and initiatives. The Summit was held on May 20, 2021– May 21, 2021, and was preceded by three webinars. More than 60 healthcare experts and government leaders spoke at the Summit, to nearly 500 virtual attendees. A full report of the Summit with specific policy recommendations was made to the Canadian and Indian governments.
2021年加拿大印度保健问题首脑会议(" 2021年加拿大印度保健问题首脑会议")是加拿大印度基金会组织的第三届首脑会议,其重点是保健问题,是正在举行的一系列加拿大印度专题论坛的一部分,旨在强调加拿大和印度在关键战略部门的合作机会,并向各自政府提出公共政策建议。印度工商会联合会、多伦多康复研究所-大学保健网络和印度驻多伦多总领事馆是首脑会议的共同组织者。CIHS 2021聚焦三个主题:(1)人工智能及其对战胜COVID-19的贡献;(2)生物技术及其对战胜COVID-19的贡献;(3)大流行应对和举措。峰会于2021年5月20日至21日举行,之前举行了三场网络研讨会。60多位医疗保健专家和政府领导人在峰会上向近500名虚拟与会者发表了讲话。向加拿大和印度政府提交了一份载有具体政策建议的首脑会议的完整报告。
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引用次数: 0
Chronic noncommunicable diseases and COVID-19: How they both interact 慢性非传染性疾病与新冠肺炎:二者如何相互作用
IF 0.4 Pub Date : 2021-11-01 DOI: 10.4103/2468-8827.330648
M. Farkouh, Arrti Bhasin, D. Ko, Aviral Roy, I. Khurana, A. Chockalingam
This white paper will summarize the key topics, outcomes, and recommendations from the Canada-India Healthcare Summit 2021 COVID-19 Pandemic Response and Initiatives sessions held on May 20–21, 2021. In particular, the authors have focused their attention on topics on the effect of COVID-19 on noncommunicable diseases, depression, research on substance abuse, and post COVID-19 pain management. The authors have developed a better understanding of these conditions' interplay with COVID-19 infection. The paper also deals with important topics around the effects of NCD on COVID-19 and vice versa, as well as key considerations around research and development, innovation, policy, and finally, summarizes the ways forward in which Canada and India could collaborate strategically. We also include key points raised during the summit.
本白皮书将总结2021年5月20日至21日举行的加拿大-印度医疗保健峰会2021新冠肺炎疫情应对和倡议会议的关键主题、成果和建议。特别是,作者将注意力集中在新冠肺炎对非传染性疾病的影响、抑郁症、药物滥用研究和新冠肺炎后疼痛管理等主题上。作者对这些条件与新冠肺炎感染的相互作用有了更好的理解。该论文还涉及非传染性疾病对新冠肺炎的影响,以及研究与开发、创新、政策等方面的主要考虑因素,最后总结了加拿大和印度可以进行战略合作的方式。我们还包括首脑会议期间提出的要点。
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引用次数: 1
期刊
International Journal of Noncommunicable Diseases
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