Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112756
Fábio Cardoso, C. G. Lima da Silva, Sávio Samuel Feitosa Machado, Sionara Melo Figueiredo de Carvalho, Modesto Leite Rolim Neto, Jaime Emanuel Brito Araújo
{"title":"Vaccination against COVID-19 and SARS-COV-2 in people living with HIV","authors":"Fábio Cardoso, C. G. Lima da Silva, Sávio Samuel Feitosa Machado, Sionara Melo Figueiredo de Carvalho, Modesto Leite Rolim Neto, Jaime Emanuel Brito Araújo","doi":"10.5114/hivar.2022.112756","DOIUrl":"https://doi.org/10.5114/hivar.2022.112756","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"21 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82655757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112580
I. Furtado, S. Valdoleiros, J. Fragoso, O. Vasconcelos, M. Gonçalves, R. Sarmento-Castro
{"title":"Clinical experience with dolutegravir: efficacy, safety, and tolerability","authors":"I. Furtado, S. Valdoleiros, J. Fragoso, O. Vasconcelos, M. Gonçalves, R. Sarmento-Castro","doi":"10.5114/hivar.2022.112580","DOIUrl":"https://doi.org/10.5114/hivar.2022.112580","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"24 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81612404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112682
Isabella Damiani, M. N. Naval Machado, Melissa Rodrigues de Araújo, Antônio Adilson Soares de Lima
{"title":"Primary syphilis as oral lesion in HIV/AIDS-positive patient: case report of unusual manifestation","authors":"Isabella Damiani, M. N. Naval Machado, Melissa Rodrigues de Araújo, Antônio Adilson Soares de Lima","doi":"10.5114/hivar.2022.112682","DOIUrl":"https://doi.org/10.5114/hivar.2022.112682","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"138 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80527228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112718
Rosa Nimmy Mathew, Manjula M.Y.
{"title":"Self-esteem and self-efficacy among HIV-positive adolescents: an intervention study","authors":"Rosa Nimmy Mathew, Manjula M.Y.","doi":"10.5114/hivar.2022.112718","DOIUrl":"https://doi.org/10.5114/hivar.2022.112718","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"241 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75917780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112758
B. Teshale, S. Awoke
Introduction: Acquired immune deficiency syndrome (AIDS) is a medical condition caused by human immunodeficiency virus (HIV), and has been the major concern worldwide. Despite antiretroviral treatment (ART) treatment showing significant clinical importance by meeting the goal of therapy, there is still a number of deaths due to socio-economic, demographic, and health-related factors. Therefore, this study was aimed to investigate the survival status and predictors of mortality for adult HIV-positive patients treated with ART. Material and methods: A retrospective cohort study was conducted with 1,285 of HIV-infected patients aged 15 years and greater, who were enrolled in ART at Mizan-Tepi University Teaching Hospital from September, 2007 to January, 2015. A multivariable Cox regression model was applied to assess significant predictors of mortality. Results: During follow-up period, a total of 1,285 patients contributed to 59,237 person/year of followup, and 273 (21%) of the patients died, showing overall incidence rate of 4.6 per 1,000 persons/ year (273/59,237). The median follow-up period was 44 months. During follow-up, 273 (21%) patients died, of whom nearly 32% and 12% of deaths occurred within 6 months and between 6 and 12 months of highly active antiretroviral therapy (HAART) initiation, respectively. Conclusions: Multivariable Cox proportional hazards model revealed that having concomitant tuberculosis infection, low baseline CD4 count, low baseline weight, living in rural area, using of a substance, older age, lower educational level, higher World Health Organization (WHO) clinical stages, functional status, and marital status were all significantly associated with progression to death for HIV/AIDS-infected patients. HIV AIDS Rev 2022; 21, 1: DOI: https://doi.org/10.5114/hivar.2022.112758
{"title":"Survival analysis and predictors of mortality for adult HIV/AIDS patients following antiretroviral therapy in Mizan-Tepi University Teaching Hospital, Southwest Ethiopia: a retrospective cohort study","authors":"B. Teshale, S. Awoke","doi":"10.5114/hivar.2022.112758","DOIUrl":"https://doi.org/10.5114/hivar.2022.112758","url":null,"abstract":"Introduction: Acquired immune deficiency syndrome (AIDS) is a medical condition caused by human immunodeficiency virus (HIV), and has been the major concern worldwide. Despite antiretroviral treatment (ART) treatment showing significant clinical importance by meeting the goal of therapy, there is still a number of deaths due to socio-economic, demographic, and health-related factors. Therefore, this study was aimed to investigate the survival status and predictors of mortality for adult HIV-positive patients treated with ART. Material and methods: A retrospective cohort study was conducted with 1,285 of HIV-infected patients aged 15 years and greater, who were enrolled in ART at Mizan-Tepi University Teaching Hospital from September, 2007 to January, 2015. A multivariable Cox regression model was applied to assess significant predictors of mortality. Results: During follow-up period, a total of 1,285 patients contributed to 59,237 person/year of followup, and 273 (21%) of the patients died, showing overall incidence rate of 4.6 per 1,000 persons/ year (273/59,237). The median follow-up period was 44 months. During follow-up, 273 (21%) patients died, of whom nearly 32% and 12% of deaths occurred within 6 months and between 6 and 12 months of highly active antiretroviral therapy (HAART) initiation, respectively. Conclusions: Multivariable Cox proportional hazards model revealed that having concomitant tuberculosis infection, low baseline CD4 count, low baseline weight, living in rural area, using of a substance, older age, lower educational level, higher World Health Organization (WHO) clinical stages, functional status, and marital status were all significantly associated with progression to death for HIV/AIDS-infected patients. HIV AIDS Rev 2022; 21, 1: DOI: https://doi.org/10.5114/hivar.2022.112758","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"55 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74362040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112762
Vikas Kumar, H. Joshi, I. Pandey
Human immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified. HIV belongs to class of retroviruses, known as ‘lenti-viruses’ and ‘slow’ viruses. A literature assessment was conducted through several reliable national and international journals as well as books and monographs, to investigate reverse transcriptase inhibitor (RI) from human immunodeficiency virus type 1 (HIV-1). Reverse transcriptase inhibitor limits the reverse transcriptase activity, which is considered the key enzyme of retroviral multiplication process, and eventually prevents infection and progression of retroviruses. In the current paper, more than twenty-five drugs were presented, which are used for management/treatment of AIDS. The aim of the present review was to summarize the latest update on reverse transcriptase inhibition. Lately, significant advancement has been observed on the growth of HIV-drugs targeting reverse transcriptase enzyme. There is a continuous increase in various compounds with anti-HIV activity and isolated from natural sources. The present review provided a selection of publications concerning the topic. Salient features of reverse transcriptase inhibitors (both NRTIs and NNRTI's) and possibility for development of new chemical entity were presented.
{"title":"Reverse transcriptase inhibition: a way to defeat HIV","authors":"Vikas Kumar, H. Joshi, I. Pandey","doi":"10.5114/hivar.2022.112762","DOIUrl":"https://doi.org/10.5114/hivar.2022.112762","url":null,"abstract":"Human immunodeficiency virus (HIV) induces disease in humans that is known as AIDS (acquired immunodeficiency syndrome). First AIDS cases were registered in 1981, and later, types of HIV infection, such as HIV-1 and HIV-2 were identified. HIV belongs to class of retroviruses, known as ‘lenti-viruses’ and ‘slow’ viruses. A literature assessment was conducted through several reliable national and international journals as well as books and monographs, to investigate reverse transcriptase inhibitor (RI) from human immunodeficiency virus type 1 (HIV-1). Reverse transcriptase inhibitor limits the reverse transcriptase activity, which is considered the key enzyme of retroviral multiplication process, and eventually prevents infection and progression of retroviruses. In the current paper, more than twenty-five drugs were presented, which are used for management/treatment of AIDS. The aim of the present review was to summarize the latest update on reverse transcriptase inhibition. Lately, significant advancement has been observed on the growth of HIV-drugs targeting reverse transcriptase enzyme. There is a continuous increase in various compounds with anti-HIV activity and isolated from natural sources. The present review provided a selection of publications concerning the topic. Salient features of reverse transcriptase inhibitors (both NRTIs and NNRTI's) and possibility for development of new chemical entity were presented.","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"77 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80150521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.113389
R. Safdari, Seyedahmad Seyedalinaghi, N. Mohammadzadeh, T. Noori, Pakzad Rahmati, Kowsar Qaderi, F. Voltarelli, E. Mehraeen
{"title":"Developing Aysoo: a mobile-based self-management application for people living with HIV","authors":"R. Safdari, Seyedahmad Seyedalinaghi, N. Mohammadzadeh, T. Noori, Pakzad Rahmati, Kowsar Qaderi, F. Voltarelli, E. Mehraeen","doi":"10.5114/hivar.2022.113389","DOIUrl":"https://doi.org/10.5114/hivar.2022.113389","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"162 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73127657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.5114/hivar.2022.112852
Minyechil Alehegn
{"title":"Application of machine learning and deep learning for the prediction of HIV/AIDS","authors":"Minyechil Alehegn","doi":"10.5114/hivar.2022.112852","DOIUrl":"https://doi.org/10.5114/hivar.2022.112852","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"14 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82283366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.5114/hivar.2021.109264
Jacob Musinsky, A. Noy
{"title":"Remission of a primary effusion lymphoma with initiation of highly active antiretroviral therapy and antiviral therapy in a previously untreated HIV-positive patient","authors":"Jacob Musinsky, A. Noy","doi":"10.5114/hivar.2021.109264","DOIUrl":"https://doi.org/10.5114/hivar.2021.109264","url":null,"abstract":"","PeriodicalId":53943,"journal":{"name":"HIV & AIDS Review","volume":"129 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73354295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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