Sandy beaches are fragile ecosystems situated at the interface of land and sea, highly vulnerable to both anthropogenic and environmental drivers that threaten their ecological integrity. Fishing intensity and climate change are among the most significant pressures, with the former being difficult to regulate in open-access systems and the latter increasingly disrupting key ecosystem services, such as biodiversity and sediment stability. Despite separate evaluations of these drivers, long-term studies examining their combined impacts within social-ecological systems are limited. This study leverages a unique 40-year dataset of beach sampling surveys, coupled with morphodynamic, climatic, and economic variables, to evaluate their relative effects on the abundance of the adult yellow clam (Mesodesma mactroides) population subject to artisanal harvesting at Barra del Chuy beach, Uruguay. Using MARIMA models and autocorrelation analysis, the study identified a transition in dominant drivers: human-driven factors shaped abundance from 1983 to 1992, while climate-driven factors prevailed from 1993 to 2023. This shift marks a transition from economic to environmental dominance, resulting in a regime shift characterized by a sudden and persistent alteration in yellow clam abundance. These changes reinforce previous findings that detected shifts in community structure, ecosystem dynamics, and the loss of key ecological functions. The long-term analysis reveals a synergistic interaction between regional climatic factors and local morphodynamic variables (e.g., grain size), while economic drivers, such as CPUE and unit price, play a secondary role. These results emphasize the importance of adaptive management strategies that integrate climate-driven dynamics with traditional economic considerations to foster the sustainable harvesting and conservation of sandy beach ecosystems.