Journal of Nutrition Health & Aging最新文献

{"title":"Cross-sectional association of food insecurity with loneliness in older adults: The role of sex, age, and psychosomatic factors","authors":"Razak M. Gyasi ,&nbsp;Emelia Aikins ,&nbsp;André Hajek ,&nbsp;Jones Opoku-Ware ,&nbsp;Benjamin Appiah Osei ,&nbsp;Joana Kwabena-Adade ,&nbsp;Louis Jacob ,&nbsp;Masoud Rahmati ,&nbsp;George Dakurah ,&nbsp;Karl Peltzer","doi":"10.1016/j.jnha.2024.100328","DOIUrl":"10.1016/j.jnha.2024.100328","url":null,"abstract":"<div><h3>Objective</h3><p>Food insecurity (FI) is a critical social determinant of poor psychosocial health. While data on the specific roles of sex and age in the FI-loneliness link among older adults are limited, the underlying mechanisms are largely unknown. This study examines the age-sex-specific associations of FI with loneliness among older adults in Ghana and quantifies the extent to which psychosomatic factors mediate the association.</p></div><div><h3>Methods</h3><p>We analyzed cross-sectional data from the Aging, Health, Psychological, and Health-seeking Behavior Study in Ghana. The past 30-day FI was assessed using items on hunger and breakfast skipping frequency due to a lack of resources. We assessed loneliness severity with the University of California, Los Angeles 3-item Loneliness Scale. Multivariable OLS regressions and bootstrapping mediation analysis using the Hayes PROCESS macro plug-in were used to evaluate the associations.</p></div><div><h3>Results</h3><p>We included 1,201 individuals aged ≥50 years (mean = 62.9 [SD = 11.9]; women = 63.3%). The prevalence of loneliness was 17.7%. The prevalence of moderate and severe FI was 44.0% and 8.5%, respectively. In the adjusted model, greater FI was significantly associated with loneliness severity (<em>B</em> = .22, <em>SE</em> = .029, <em>p</em> &lt; .001). We found significant interactive effects of FI × age (<em>B</em> = −.17, <em>SE</em> = .023, <em>p</em> &lt; .01) and FI × sex (<em>B</em> = −.28, <em>SE</em> = .036, <em>p</em> &lt; .001) on loneliness. Thus, the FI-loneliness link was respectively more marked among women (<em>B</em> = .25, <em>SE</em> = .035, <em>p</em> &lt; .001) and ≥65 age groups (<em>B</em> = .34, <em>SE</em> = .041, <em>p</em> &lt; .001) than men (<em>B</em> = .16, <em>SE</em> = .051, <em>p</em> &lt; .01) and those aged 50−64 (<em>B</em> = .22; <em>SE</em> = .040, <em>p</em> &lt; .001). Finally, comorbid depression/anxiety (41.07%), hopelessness (48.6%), worthlessness (42.1%), functional limitations (8.2%), and pain severity (6.4%) mediated the FI-loneliness association.</p></div><div><h3>Conclusions</h3><p>Age- and sex-specific associations between FI and loneliness exist among older Ghanaians. Addressing FI in concert with psychosomatic problems in older adults may contribute meaningfully to reducing loneliness in later life.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100328"},"PeriodicalIF":4.3,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004159/pdfft?md5=7e76edb2aa3c9418fbb56524ee1ff274&pid=1-s2.0-S1279770724004159-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141890981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank","authors":"Zihao Jiang ,&nbsp;Jieyu Chen ,&nbsp;Siqi Wu ,&nbsp;Shuai Ji ,&nbsp;Ying Yang ,&nbsp;Wen Fang ,&nbsp;Ziwei Li ,&nbsp;Jingxin Lin ,&nbsp;Jie Chen ,&nbsp;Chuanghai Wu ,&nbsp;Hiu Yee Kwan ,&nbsp;Yigui Lai ,&nbsp;Xiaoshan Zhao","doi":"10.1016/j.jnha.2024.100319","DOIUrl":"10.1016/j.jnha.2024.100319","url":null,"abstract":"<div><h3>Background</h3><p>The relationship between serum uric acid (SUA) levels and brain-related health remains uncertain.</p></div><div><h3>Objectives</h3><p>This study aimed to investigate the relationship between SUA levels and some neurodegenerative disorders and brain structure.</p></div><div><h3>Design</h3><p>A longitudinal study.</p></div><div><h3>Setting and participants</h3><p>384,517 participants who did not have stroke, dementia, and Parkinsonism, with complete urate testes and covariates were included.</p></div><div><h3>Measurements</h3><p>Cox proportional hazards models, competing risk models, and restricted cubic spine models were applied.</p></div><div><h3>Results</h3><p>During the median follow-up time of 12.7 years (interquartile range [IQR]:12.0, 13.5), 7821 (2.0%) participants developed stroke, 5103 (1.3%) participants developed dementia, and 2341 (0.6%) participants developed Parkinsonism. Nonlinear relationships were identified between SUA levels and stroke (J-shaped), dementia, and Parkinsonism (U-shaped). SUA levels of 4.2 mg/dl, 6.4 mg/dl, and 6.6 mg/dl yielded the lowest risk of stroke, dementia, and Parkinsonism, respectively. Besides, we found high SUA levels reduced the volumes of total brain, grey matter, white matter, grey matter in the hippocampus, and hippocampus, but increased lateral-ventricle volume. Inflammation accounted for 9.1% and 10.0% in the association of SUA with stroke and lateral-ventricle volume.</p></div><div><h3>Conclusions</h3><p>Lower SUA levels increased the risk of Parkinsonism, while both lower and higher SUA levels were positively associated with increased risk of stroke and dementia. Moreover, high SUA levels reduced brain structure volumes. Our findings suggest the association between SUA levels and brain-related disorders and highlight the importance of SUA management.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100319"},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004068/pdfft?md5=a49e566f442b46f6743377d1ebf272aa&pid=1-s2.0-S1279770724004068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and aging: advances in research and clinical practice","authors":"Philipe de Souto Barreto","doi":"10.1016/j.jnha.2024.100336","DOIUrl":"10.1016/j.jnha.2024.100336","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 8","pages":"Article 100336"},"PeriodicalIF":4.3,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004238/pdfft?md5=ff0168c8d269f6700e1c944e2bf52292&pid=1-s2.0-S1279770724004238-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142039602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic targets for muscle weakness in older adults: proteome-wide Mendelian randomization and colocalization analyses","authors":"Shuai-Kang Wang ,&nbsp;Qi-Jun Wang ,&nbsp;Xuan Zhao ,&nbsp;Peng Wang ,&nbsp;Xiang-Yu Li ,&nbsp;Wei Wang ,&nbsp;Shi-Bao Lu","doi":"10.1016/j.jnha.2024.100325","DOIUrl":"10.1016/j.jnha.2024.100325","url":null,"abstract":"<div><h3>Background</h3><p>Recent research highlights the importance of muscular strength as a key factor in physical fitness, a strong indicator of overall mortality risk, and a vital target for preventing chronic diseases. This study used a proteome-wide Mendelian randomization analysis plus colocalization analysis for low hand grip strength to explore potential therapeutic targets for muscle weakness.</p></div><div><h3>Methods</h3><p>We conducted two two-sample Mendelian randomization analyses from four cohorts to identify and validate the causal relationship between plasma proteins and low grip strength. We also employed bidirectional Mendelian randomization analysis with Steiger filtering, Bayesian co-localization, and phenotype scanning to detect reverse causality, thereby consolidating our Mendelian randomization findings. Downstream analyses were also undertaken of identified proteins, including knockout models, enrichment analyses, and protein-protein interaction networks. Finally, we assessed the druggability of the identified proteins.</p></div><div><h3>Results</h3><p>At Bonferroni significance (P &lt; 6.82 × 10⁻⁵), Mendelian randomization analysis revealed that three proteins were causally associated with low grip strength. Increased MGP (OR = 0.85) and HP (OR = 0.96) decreased the risk of low grip strength, whereas elevated ART4 (OR = 1.06) increased the risk of low grip strength. None of the three proteins had reverse causality with low grip strength. Bayesian co-localization suggested that MGP shared the same variant with low grip strength (coloc.abf-PPH4 = 0.826). Further downstream analyses showed that MGP, which is highly expressed in musculoskeletal system, is a potential novel target for muscle weakness.</p></div><div><h3>Conclusions</h3><p>The proteome-wide Mendelian randomization investigation identified three proteins associated with the risk of muscle weakness. MGP, HP, and ART4 deserve further investigation as potential therapeutic targets for muscle weakness.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100325"},"PeriodicalIF":4.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004123/pdfft?md5=27aade60444a45727b9127a91e5e0986&pid=1-s2.0-S1279770724004123-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of visceral adiposity index with phenotypic age acceleration: insight from NHANES 1999–2010","authors":"Cheng Xu ,&nbsp;Zhen Song ,&nbsp;Jia-ni Wang ,&nbsp;Chong-chao Li","doi":"10.1016/j.jnha.2024.100323","DOIUrl":"10.1016/j.jnha.2024.100323","url":null,"abstract":"<div><h3>Background</h3><p>Obesity correlates with accelerated aging. This study aims to investigate the association between the visceral adiposity index (VAI) and accelerated aging.</p></div><div><h3>Methods</h3><p>Biological aging was evaluated by phenotypic age acceleration (PhenoAgeAccel). Utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2010, we employed weighted multivariable logistic regression models, along with subgroup analysis, to examine the association between VAI and PhenoAgeAccel. Moreover, smooth curve fitting was utilized to identify potential nonlinear association, complemented by a two-piece linear regression model to investigate threshold effects.</p></div><div><h3>Results</h3><p>Of the included 11,340 participants aged 20 years and older, the mean (95% CI) age was 46.569 (45.946, 47.191) years, and 49.189% were male. The mean (95% CI) VAI for all participants was 2.176 (2.114, 2.238), and the mean (95% CI) PhenoAgeAccel was −6.306 (−6.618, −5.994) years. In the fully adjusted model, each incremental unit increase of VAI was associated with a 0.312-year increase in PhenoAgeAccel (β = 0.312, 95% CI: 0.217, 0.408). This positive association was more statistically significant among individuals with cancer. Furthermore, a segmented association was observed between VAI and PhenoAgeAccel, with a turning point identified at 10.543. Below this threshold, VAI exhibited a positive correlation with PhenoAgeAccel (β = 0.617, 95% CI: 0.499, 0.735), while beyond it, the association became nonsignificant.</p></div><div><h3>Conclusion</h3><p>This study demonstrated a positive association between VAI and accelerated aging within a nationally representative population. The findings suggest that controlling adiposity may exert anti-aging effects and help prevent aging-related diseases.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100323"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400410X/pdfft?md5=db025a6ca92e591423f7244c02d260df&pid=1-s2.0-S127977072400410X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical performance changes as clues to late-life blood pressure changes with advanced age: the osteoporotic fractures in men study","authors":"Deepika R. Laddu ,&nbsp;Hajwa Kim ,&nbsp;Peggy M. Cawthon ,&nbsp;Michael J. LaMonte ,&nbsp;Shane A. Phillips ,&nbsp;Jun Ma ,&nbsp;Marcia L. Stefanick","doi":"10.1016/j.jnha.2024.100317","DOIUrl":"10.1016/j.jnha.2024.100317","url":null,"abstract":"<div><h3>Objectives</h3><p>This study examined whether changes in late-life physical performance are associated with contemporaneous changes in blood pressure (BP) in older men.</p></div><div><h3>Design</h3><p>prospective cohort study over 7 years.</p></div><div><h3>Setting and Participants</h3><p>Physical performance (gait speed, grip strength, chair stand performance) and clinic-measured BP at baseline and at least one follow-up (year 7 or 9) were assessed in 3,135 men aged ≥65 y enrolled in the Osteoporotic Fractures in Men Study (MrOS).</p></div><div><h3>Methods</h3><p>Generalized estimating equation analysis of multivariable models with standardized point estimates (β [95% CI]) described longitudinal associations between physical performance and BP changes in participants overall, and stratified by baseline cardiovascular disease (CVD), antihypertensive medication use (none, ≥1), and enrollment age (&lt;75 years; ≥75 years).</p></div><div><h3>Results</h3><p>Overall, positive associations (z-score units) were found between each increment increase in gait speed and systolic (SBP) (0.74 [0.22, 1.26]) and grip strength (0.35 [0.04, 0.65]) or gait speed (0.55 [0.24, 0.85]) with diastolic (DBP). Better grip strength and chair stand performance over time were associated with 1.83 [0.74, 2.91] and 3.47 [0.20, 6.74] mmHg higher SBP, respectively in men with CVD at baseline (both interaction <em>P</em> &lt; .05). Gait speed increases were associated with higher SBP in men without CVD (0.76 [0.21, 1.32]), antihypertensive medication non-users (0.96 [0.30, 1.62]), aged &lt;75 years (0.73 [0.05, 1.41]) and ≥75 years (0.76 [0.06, 1.47]). Similar positive, but modest associations for DBP were observed with grip strength in men with CVD, antihypertensive medication non-users, and aged &lt;75 years, and with gait speed in men without CVD, aged &lt;75 years, and irrespective of antihypertensive medication use.</p></div><div><h3>Conclusion</h3><p>In older men, better physical performance is longitudinally associated with higher BP. Mechanisms and implications of these seemingly paradoxical findings, which appears to be modified by CVD status, antihypertensive medication use, and age, requires further investigation.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100317"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004044/pdfft?md5=f631145091c6477e47bf86b469c82f5d&pid=1-s2.0-S1279770724004044-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering the direct relations between nutrients and epigenetic ageing","authors":"Pol Grootswagers ,&nbsp;Daimy Bach ,&nbsp;Ynte Biemans ,&nbsp;Pariya Behrouzi ,&nbsp;Steve Horvath ,&nbsp;Charlotte S. Kramer ,&nbsp;Simin Liu ,&nbsp;JoAnn E. Manson ,&nbsp;Aladdin H. Shadyab ,&nbsp;James D. Stewart ,&nbsp;Eric Whitsel ,&nbsp;Bo Yang ,&nbsp;Lisette de Groot","doi":"10.1016/j.jnha.2024.100324","DOIUrl":"10.1016/j.jnha.2024.100324","url":null,"abstract":"<div><h3>Background</h3><p>Along with the ageing of society, the absolute prevalence of age-related diseases is expected to rise, leading to a substantial burden on healthcare systems and society. Thus, there is an urgent need to promote healthy ageing. As opposed to chronological age, biological age was introduced to accurately represent the ageing process, as it considers physiological deterioration that is linked to morbidity and mortality risk. Furthermore, biological age responds to various factors, including nutritional factors, which have the potential to mitigate the risk of age-related diseases. As a result, a promising biomarker of biological age known as the <em>epigenetic clock</em> has emerged as a suitable measure to investigate the direct relations between nutritional factors and ageing, thereby identifying potential intervention targets to improve healthy ageing.</p></div><div><h3>Methods</h3><p>In this study, we analysed data from 3,969 postmenopausal women from the Women's Health Initiative to identify nutrients that are associated with the rate of ageing by using an accurate measure of biological age called the PhenoAge epigenetic clock. We used Copula Graphical Models, a data-driven exploratory analysis tool, to identify direct relationships between nutrient intake and age-acceleration, while correcting for every variable in the dataset.</p></div><div><h3>Results</h3><p>We revealed that increased dietary intakes of coumestrol, beta-carotene and arachidic acid were associated with decelerated epigenetic ageing. In contrast, increased intakes of added sugar, gondoic acid, behenic acid, arachidonic acid, vitamin A and ash were associated with accelerated epigenetic ageing in postmenopausal women.</p></div><div><h3>Conclusion</h3><p>Our study discovered direct relations between nutrients and epigenetic ageing, revealing promising areas for follow-up studies to determine the magnitude and causality of our estimated diet-epigenetic relationships.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100324"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004111/pdfft?md5=f9b4c63712ec99ea8f23c39c97eab41d&pid=1-s2.0-S1279770724004111-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The weight-adjusted waist index and frailty: A cohort study from the China Health and Retirement Longitudinal Study","authors":"Jinhua Luo ,&nbsp;Hailian Deng ,&nbsp;Yueying Wu ,&nbsp;Tuming Zhang ,&nbsp;Yuying Cai ,&nbsp;Yu Yang","doi":"10.1016/j.jnha.2024.100322","DOIUrl":"10.1016/j.jnha.2024.100322","url":null,"abstract":"<div><h3>Objectives</h3><p>This cohort study’s aim was to assess the association between the weight-adjusted waist index (WWI) and frailty among middle-aged and elderly individuals in China.</p></div><div><h3>Methods</h3><p>Seven-year complete follow-up data from 10,349 adults aged ≥45 years, initially surveyed in 2 011 in the China Health and Retirement Longitudinal Study, were analyzed, including clinical demographic characteristics, anthropometric indices, frailty scores, and relevant covariates. The WWI was calculated as waist circumference divided by the square root of the body weight. Frailty was evaluated using the Frailty Index. Relationships between the WWI and frailty were evaluated via Cox proportional hazards modeling. Receiver operating characteristic curve analyses assessed the effectiveness of obesity-related indicators in predicting frailty.</p></div><div><h3>Results</h3><p>Over a median 84-month follow-up period, frailty occurred in 23.7% (2453/10,349) of participants. After potential confounder adjustment, the WWI positively correlated with frailty (adjusted hazard ratio: 1.14; 95% confidence interval: 1.08–1.20; <em>p</em> &lt; 0.001). After WWI-stratification into quartiles based on frailty and covariate adjustment, regression analyses were conducted; the adjusted hazard ratios exhibited a significant upward trend (<em>p</em> &lt; 0.001). The subgroup analyses revealed higher positive correlations between the WWI and frailty in males and those aged ≥65 years and lower correlations in those with a high school or higher educational level and in married or cohabiting individuals. The strong positive correlation was unaltered in the other subgroup analyses. The WWI outperformed all other obesity-related indicators as a frailty predictor.</p></div><div><h3>Conclusions</h3><p>The WWI is a dependable and innovative obesity-related predictor of frailty and could help in mitigating its development.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100322"},"PeriodicalIF":4.3,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004093/pdfft?md5=3c8448c7f923ca8325c7ab3918951d41&pid=1-s2.0-S1279770724004093-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of frailty and sarcopenia with short-term mortality in older critically ill patients","authors":"Weimin Bai ,&nbsp;Hongbo Ge ,&nbsp;Han Han ,&nbsp;Juan Xu ,&nbsp;Lijie Qin","doi":"10.1016/j.jnha.2024.100321","DOIUrl":"10.1016/j.jnha.2024.100321","url":null,"abstract":"<div><h3>Background</h3><p>There is still no study on the use of the SARC-CalF questionnaire for older critically ill patients. Moreover, there is limited evidence on whether a combination of sarcopenia and frailty can provide incremental improvements in risk stratification for older critically ill patients.</p></div><div><h3>Methods</h3><p>A total of 653 patients older than 60 years were recruited. We used the clinical frailty scale (CFS) and SARC-CalF questionnaire to assess the frailty status and sarcopenia risk, respectively, of older patients shortly after admission to the ICU. The effect of frailty and sarcopenia risk on ICU mortality and 30-day mortality was evaluated.</p></div><div><h3>Results</h3><p>A total of 147 (22.5%) patients died in the ICU, and 187 (28.6%) patients died within 30 days after ICU admission. The CFS score was associated with increased ICU mortality [per 1-score increase: odds ratio (OR) = 1.222, 95% confidential interval (CI): 1.003–1.489] and 30-day mortality (per 1-score increase: OR = 1.307, 95% CI: 1.079–1.583). The SARC-CalF score was also associated with increased ICU mortality (per 1-score increase: OR = 1.204, 95% CI: 1.120–1.294) and 30-day mortality (per 1-score increase: OR = 1.247, 95% CI: 1.163–1.337). The addition of the CFS + SARC-CalF score to Acute Physiology and Chronic Health Evaluation (APACHE) II improved discrimination and reclassified ICU and 30-day mortality risk.</p></div><div><h3>Conclusions</h3><p>Sarcopenia risk assessed by the SARC-CalF questionnaire provided independent prognostic information for older critically ill patients. A combination of sarcopenia and frailty improved the prediction of mortality for older critically ill patients and thus might be useful in the clinical decision-making process.</p></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 8","pages":"Article 100321"},"PeriodicalIF":4.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1279770724004081/pdfft?md5=475a8ee0a57ca721d85cf5af1d655a8c&pid=1-s2.0-S1279770724004081-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the molecular to the functional level: the aging continuum through blood pressure trajectories","authors":"L. Bencivenga ,&nbsp;L. Rouch","doi":"10.1016/j.jnha.2024.100320","DOIUrl":"10.1016/j.jnha.2024.100320","url":null,"abstract":"","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"28 9","pages":"Article 100320"},"PeriodicalIF":4.3,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S127977072400407X/pdfft?md5=8eacb29920447de77693f618c4218052&pid=1-s2.0-S127977072400407X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141731887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}