Journal of Nutrition Health & Aging最新文献

英文中文

Nonlinear Dose-Response and Calcium-Magnesium Interactions of Dietary Minerals with Cognitive Function in Older Adults 老年人膳食矿物质与认知功能的非线性剂量反应和钙镁相互作用

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-03 DOI: 10.1016/j.jnha.2025.100669

Xingchen He , Yaxuan Yan , Jiawen Wang , Yijia Lin , Xinyi Wu , Min Li , Tianyu Zhong , Xuliang Weng

引用次数: 0

Breakfast consumption behavior was positively associated with cognitive function in Chinese adults aged 55 years and above 在55岁及以上的中国成年人中，早餐消费行为与认知功能呈正相关

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-30 DOI: 10.1016/j.jnha.2025.100662

Xiaoyun Song , Xiaofang Jia , Bing Zhang , Huijun Wang

Objectives

This study aims to investigate the relationship between breakfast consumption behavior and cognitive function in Chinese adults aged 55 years and above, and the mediating effect of diet quality.

Methods

Data were drawn from the China Health and Nutrition Survey (CHNS) 1997, 2000, 2004, 2006, 2015, and 2018. Participants aged 55 years and above who had at least two waves of completed data on dietary measures and cognitive assessments were eligible. Breakfast consumption behavior was counted during the 3-day 24-h survey period and classified into breakfast skipping and breakfast consumption. Cognitive function was examined using part items of the Telephone Interview for Cognitive Status-modified. Three-level linear mixed-effects models were performed to examine the relationship between breakfast consumption behavior and cognitive function due to the repeated-measured data. The Mediating effect of diet quality, indicated by the China Elderly Dietary Guidelines Index 2022 (CDGI 2022-E), was explored.

Results

A total of 5462 participants were included. Significant associations between breakfast consumption behavior and global cognitive score (breakfast skipping vs. consumption: β = −0.77, 95%CI: −1.23, −0.31) as well as global cognitive composite z-score (breakfast skipping vs. consumption: β = −0.22, 95%CI: −0.30, −0.15) were observed in total participants. Similar significant associations were found in participants stratified by age at baseline or gender. Overall diet quality assessed by CDGI 2022-E played a modest mediating role between breakfast consumption behavior and cognitive score.

Conclusions

Habitual breakfast consumption may have the advantage of improving cognitive function in the Chinese older population, in which overall diet quality exerted a mediating effect.

目的探讨中国55岁及以上成年人早餐消费行为与认知功能的关系，以及饮食质量的中介作用。方法数据来源于1997年、2000年、2004年、2006年、2015年和2018年中国健康与营养调查（CHNS）。年龄在55岁及以上的参与者在饮食测量和认知评估方面至少有两波完整的数据是符合条件的。统计3天24小时调查期间的早餐消费行为，分为不吃早餐和吃早餐。认知功能测试采用认知状态修正电话访谈的部分项目。由于重复测量的数据，采用三水平线性混合效应模型来检验早餐消费行为与认知功能之间的关系。以《中国老年人膳食指南指数2022》（CDGI 2022- e）为指标，探讨膳食质量的中介作用。结果共纳入5462名受试者。在所有参与者中，早餐消费行为与整体认知得分（不吃早餐vs.消费：β = - 0.77, 95%CI: - 1.23, - 0.31）以及整体认知复合z得分（不吃早餐vs.消费：β = - 0.22, 95%CI: - 0.30, - 0.15）之间存在显著关联。在按基线年龄或性别分层的参与者中也发现了类似的显著关联。CDGI 2022-E评估的整体饮食质量在早餐消费行为与认知评分之间起适度的中介作用。结论常规早餐可能对老年人认知功能有改善作用，其中整体饮食质量起中介作用。

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引用次数: 0

Centenarian athletes: The paradigm of healthy longevity? 百岁运动员：健康长寿的典范？

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-29 DOI: 10.1016/j.jnha.2025.100665

Ángel Buendía-Romero , Enrique Higueras-Liébana , Luis M. Alegre , Ignacio Ara , Pedro L. Valenzuela

引用次数: 0

Response to “Letter to the editor on: Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study” 对“致编辑的信：牙齿脱落、饮食质量和认知能力下降：一项15年的纵向研究”的回复

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-29 DOI: 10.1016/j.jnha.2025.100667

Lewis Winning , Gerard J. Linden

引用次数: 0

Letter to the editor on: “Tooth loss, diet quality, and cognitive decline: A 15-year longitudinal study” 致编辑的信：“牙齿脱落、饮食质量和认知能力下降：一项15年的纵向研究”

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-29 DOI: 10.1016/j.jnha.2025.100666

Jinyu Wu , Wen Wang , Kuncheng Yang

引用次数: 0

Association between ionized calcium levels and 3-months mortality in geriatric patients hospitalized for COVID-19 因COVID-19住院的老年患者3个月死亡率与离子钙水平的关系

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-28 DOI: 10.1016/j.jnha.2025.100661

Audrey Boudaille , Alexis Bourgeais , Mathieu Corvaisier , Olivier Brière , Jennifer Gautier , Cédric Annweiler , on behalf of the GERIA-COVID study group

Objectives

The aim of this study was to determine an association between ionized calcium (CaI) levels and mortality 3 months after Covid-19 infection in geriatric population.

Design

Observational retrospective cohort study.

Setting and participants

One hundred and seventy-nine patients hospitalized in the geriatric acute care unit of Angers University Hospital were included. This specific unit specifically dedicated to COVID-19 patients was opened for 2 periods : from March 1, 2020 to June 30, 2020 and from October 1, 2020 to March 29, 2021. Covariates considered were: age, sex, Iso-Resources Groups (GIR) score ≤ 3, Parathyroid hormone (PTH), C-Reactive Protein (CRP), severe undernutrition defined as albumin < 30 g/L, history of cancer, history of cardiomyopathy, severe chronic renal failure (defined as clearance < 30 ml/min), Ordinal Scale for Clinical Improvement (OSCI) score, use of systemic corticosteroids and usual vitamin D supplementation. Direct potentiometry was also used as a covariate.

Measurements

The time elapsed between the diagnosis of COVID-19 and death was studied by survival curves calculated using Cox model in each group defined by serum CaI concentration (>1.22 and ≤1.22 mmol/L).

Results

In the Cox model, a significant association was found between CaI over 1.22 mmol/l and 3-months mortality, analyzed in an adjusted model (HR 2.40 [1.34–4.31], p = 0.003).

Conclusion

There is an association between CaI and 3 months mortality in geriatric patients hospitalized for COVID-19.

目的本研究的目的是确定老年人群感染Covid-19后3个月离子化钙（CaI）水平与死亡率之间的关系。设计：观察性回顾性队列研究。环境和参与者纳入了在昂热大学医院老年急症护理部住院的179名患者。新冠肺炎患者专用病房开放时间为2020年3月1日至2020年6月30日和2020年10月1日至2021年3月29日。考虑的协变量包括：年龄、性别、等资源组（GIR）评分≤3、甲状旁腺激素（PTH）、c反应蛋白（CRP）、严重营养不良（白蛋白≤30g /L）、癌症史、心肌病史、严重慢性肾功能衰竭（清净≤30ml /min）、临床改善顺序量表（OSCI）评分、使用全身皮质类固醇和常规补充维生素D。直接电位法也被用作协变量。以血清CaI浓度（>；1.22和≤1.22 mmol/L）定义各组，采用Cox模型计算生存曲线，观察诊断为COVID-19至死亡的时间。结果在Cox模型中，血钙浓度超过1.22 mmol/l与3个月死亡率显著相关（HR 2.40 [1.34-4.31], p = 0.003）。结论老年COVID-19住院患者的CaI与3个月死亡率存在相关性。

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引用次数: 0

Letter to the editor concerning ‘Creatinine and cystatin C-based indices for predicting sarcopenia, frailty and disability in older community-dwelling adults’ 关于“基于肌酐和胱抑素c的指标预测社区老年人肌肉减少症、虚弱和残疾”的致编辑的信

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-27 DOI: 10.1016/j.jnha.2025.100664

Longqing Yu

引用次数: 0

Nutritional practices in long-term care across five European countries: Findings from the COST Action PROGRAMMING 五个欧洲国家长期护理中的营养实践：来自成本行动规划的发现

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-26 DOI: 10.1016/j.jnha.2025.100650

Anna Rudzińska , Gulistan Bahat , Gülçin Özalp , Serdar Özkök , Sumru Savas , Biljana Petreska-Zovic , André Rodrigues , Evrydiki Kravvariti , Anne Wissendorff Ekdahl , Sofia Duque , Mirko Petrovic , Marina Kotsani , Karolina Piotrowicz

Objectives

High quality nutrition and medical nutrition therapy in long-term care (LTC) settings are essential to overcome malnutrition and ensure a better quality of life. Heterogenous and often insufficient regulations contribute to a disparity in nutritional practices across Europe. The aim of the study was to gather information on nutrition-related regulations and practices, as well as establish potential future directions in LTC settings in five European countries: Greece, North Macedonia, Poland, Portugal and Türkiye.

Design

A country-specific literature review was conducted, including analysis of national regulations on nutrition in LTC settings. Additionally, the authors discussed possible future directions for each of the areas included in the review.

Results

In all the countries included regulations regarding the nutrition of LTC residents were identified. Countries differed in the availability of nutritional guidelines for this specific population, the requirement to employ a dietitian, and the presence of a mandatory nutritional assessment. No country-specific tools were identified for screening, assessment and diagnosing malnutrition. Meals are adapted in all countries to accommodate religious and/or cultural dietary preferences.

Conclusion

Areas for significant improvement were identified in all countries. The exchange of experiences between different European countries can lead to the development of good practices and a common direction for quality improvement regulations for nutritional care in LTC.

目的：在长期护理（LTC）环境中，高质量的营养和医学营养治疗对于克服营养不良和确保更好的生活质量至关重要。不同的和往往不充分的法规导致营养实践在整个欧洲的差异。该研究的目的是收集有关营养相关法规和做法的信息，并确定五个欧洲国家（希腊、北马其顿、波兰、葡萄牙和保加利亚）LTC环境的潜在未来方向。设计进行了一项针对国家的文献综述，包括对LTC环境下国家营养法规的分析。此外，作者还讨论了综述中每个领域可能的未来发展方向。结果所有纳入的国家都明确了LTC居民的营养法规。各国在针对这一特定人群的营养指南的可用性、聘请营养师的要求以及是否存在强制性营养评估方面存在差异。没有确定用于筛查、评估和诊断营养不良的具体国家工具。所有国家的膳食都经过调整，以适应宗教和/或文化饮食偏好。结论所有国家都确定了需要显著改进的领域。不同欧洲国家之间的经验交流可以促进良好做法的发展和LTC营养保健质量改进法规的共同方向。

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引用次数: 0

Association between frequency of adding salt to foods and risk of hearing loss: A population-based cohort study using UK Biobank data 食物中添加盐的频率与听力损失风险之间的关系：一项基于人群的队列研究，使用英国生物银行数据

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-26 DOI: 10.1016/j.jnha.2025.100663

Youngji Han , Kyu-Yup Lee , Incheol Seo , Da Jung Jung

Objectives

To evaluate the association between the frequency of adding salt to food and the risk of incident hearing loss.

Design

A prospective cohort study.

Setting and participants

492,168 UK Biobank participants aged 40–69 years who were free of hearing loss at baseline (2006–2010) and followed through 2023.

Measurements

Frequency of salt addition to foods was self-reported and categorized as “Never/Rarely,” “Sometimes,” “Usually,” or “Always.” Incident hearing loss was identified using ICD-10 codes H90 and H91. Cox proportional hazards models were applied to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for demographic, lifestyle, and medical confounders. Causal mediation analyses were conducted to investigate potential intermediating roles of systemic inflammation and vascular dysfunction.

Results

Over a mean follow-up of 11 years, 19,188 participants developed hearing loss. The incidence rate increased from 3.37 to 4.33 per 1,000 person-years across ascending salt use categories. Compared with the “Never/Rarely” group, the adjusted HR for the “Always” group was 1.23 (95% CI, 1.16–1.32), with a significant dose-response relationship (p for trend <0.001). Subgroup analyses showed stronger associations among younger participants, men, and individuals without diabetes or hypertension. Mediation analysis indicated that systemic inflammatory markers, particularly glycoprotein acetyls and CRP, significantly mediated part of the association, while blood pressure and arterial stiffness did not demonstrate a significant mediating effect.

Conclusions

Frequent addition of salt to food was associated with an increased risk of incident hearing loss in a dose-dependent manner. These findings suggest that salt intake may be a modifiable risk factor for hearing loss and implicate systemic inflammation as a potential biological pathway.

目的探讨食品加盐频率与偶发性听力损失风险的关系。设计前瞻性队列研究。背景和参与者：492168名英国生物银行参与者，年龄在40-69岁之间，在基线（2006-2010）时无听力损失，随访至2023年。测量食物中添加盐的频率是自我报告的，并分为“从不/很少”、“有时”、“通常”或“总是”。使用ICD-10代码H90和H91识别偶发性听力损失。Cox比例风险模型用于估计风险比（hr）和95%置信区间（ci），并对人口统计学、生活方式和医学混杂因素进行调整。进行了因果中介分析，以调查全身性炎症和血管功能障碍的潜在中介作用。结果在平均11年的随访中，19188名参与者出现了听力损失。随着盐使用类别的增加，发病率从每1000人年3.37人增加到4.33人。与“Never/Rarely”组相比，“Always”组调整后的HR为1.23 (95% CI, 1.16-1.32)，具有显著的剂量-反应关系（p为趋势<；0.001）。亚组分析显示，年轻参与者、男性和没有糖尿病或高血压的个体之间存在更强的相关性。中介分析表明，全身炎症标志物，特别是糖蛋白乙酰基和CRP，显著介导了部分关联，而血压和动脉僵硬度没有表现出显著的中介作用。结论：食物中频繁添加盐与听力损失风险增加呈剂量依赖性。这些发现表明，盐摄入可能是听力损失的一个可改变的危险因素，并暗示全身性炎症是一个潜在的生物学途径。

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引用次数: 0

The vicious cycle of depressive symptoms and disability in older adults 老年人抑郁症状和残疾的恶性循环

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-08-25 DOI: 10.1016/j.jnha.2025.100649

Mengzhen Sun , Xiaoru Sun , Hui Zhang , Xiaoyan Jiang , Xiaofeng Wang , Qi Zhang

Background

Unidirectional researches have suggested a correlation between depressive symptoms and disability, but it remains uncertain whether this association is bidirectional.

Methods

The study is based on the 1st-10 th waves of the NHATS (National Health and Aging Trends Study). The subset A and subset B included 3,459 and 3,801 samples, respectively. A random-intercept cross-lagged panel model was employed to explore the bidirectional dynamic relationship between depressive symptoms and physical function indicators, including BADL (basic ADL), IADL (instrumental ADL), and ADL (a combination of BADL and IADL).

Results

An increase in depressive symptoms led to a decline in physical function at all levels, and vice versa. When older adults experienced poorer physical function than usual, their subsequent depressive symptoms were stronger (BADL, β = 0.082, p < 0.0001; IADL, β = 0.072, p < 0.001; ADL, β = 0.098, p < 0.0001). Conversely, an increase in earlier depressive symptoms resulted in a future decline in physical function (BADL, β = 0.042−0.057, p < 0.05; IADL, β = 0.048, p < 0.05; ADL, β = 0.061, p < 0.01).

Conclusions

This study is the first to reveal a mutually reinforcing spiral effect between increased depressive symptoms and declines in any level of physical function. These findings highlight the importance of prevention strategies guided by a unity of mental-physical approach, offering a new perspective for the coordinated management of mental and physical health, and providing scientific evidence for policymaking and resource allocation.

单向研究表明抑郁症状与残疾之间存在相关性，但这种关联是否是双向的仍不确定。方法本研究基于全国健康与老龄化趋势研究（NHATS）的第1 -10波。子集A和子集B分别包含3,459和3,801个样本。采用随机截距交叉滞后面板模型探讨抑郁症状与生理功能指标BADL（基本ADL）、IADL（工具性ADL）、ADL （BADL与IADL联合）的双向动态关系。结果抑郁症状加重导致各层次身体机能下降，反之亦然。当老年人身体功能较平时差时，他们随后的抑郁症状更强（BADL, β = 0.082, p < 0.0001； IADL, β = 0.072, p < 0.001； ADL, β = 0.098, p < 0.0001）。相反，早期抑郁症状的加重会导致未来身体功能的下降（BADL, β = 0.042 - 0.057, p < 0.05； IADL, β = 0.048, p < 0.05； ADL, β = 0.061, p < 0.01）。结论：这项研究首次揭示了抑郁症状增加和身体机能下降之间相互加强的螺旋效应。这些研究结果强调了以身心合一为指导的预防策略的重要性，为身心健康的协调管理提供了新的视角，并为政策制定和资源配置提供了科学依据。

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