Journal of Nutrition Health & Aging最新文献_第9页

Age-specific associations between intrinsic capacity impairments and self-rated health in community-dwelling adults: Insights from Taiwan longitudinal study on aging 社区居民内在能力障碍与自评健康之间的年龄关联：来自台湾老化纵向研究的见解。

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-30 DOI: 10.1016/j.jnha.2025.100688

Sheng-Ping Chu , Chi-Yun Wu , Hsi-Yu Lai , I-Tzu Chen , Lin-Chieh Meng , Chih-Kuang Liang , Ming-Yueh Chou , Wei-Ju Lee , Liang-Kung Chen , Fei-Yuan Hsiao

Background

The World Health Organization's Integrated Care for Older People framework emphasizes intrinsic capacity (IC) assessment, yet the relationship between specific intrinsic capacity impairments and self-rated health (SRH) across different age groups remains inadequately characterized.

Objectives

To analyze age-specific associations between six IC domains and self-rated health using Taiwan Longitudinal Study on Aging data, adjusting for demographic, socioeconomic, and health factors.

Methods

We extracted 3,330 participants with good or poor self-rated health, stratified into three age groups: 55−64 years (n = 1,278), 65−74 years (n = 1,011), and 75+ years (n = 1,041). Five sequential logistic regression models assessed associations between IC impairments (locomotor capacity, vitality, vision, hearing, cognition, psychological capacity) and self-rated health, adjusting for sex, education, marital status, employment, economic satisfaction, chronic conditions, smoking, drinking, physical exercise, and sleep quality.

Results

IC impairment prevalence increased with age: 17.2% (55−64), 38.2% (65−74), and 61.5% (75+). After adjustment, age-specific patterns of IC impairments associated with poor self-rated health emerged. In middle-aged adults (55−64), locomotor capacity showed the strongest association with poor self-rated health (OR = 14.61, 95% CI: 3.50–61.01), though the wide confidence interval reflects the low prevalence of impairment. Psychological capacity (OR = 5.96, 95% CI: 3.32–10.69) could thus be the most dominant IC impairment that is linked to poor self-rated health in this age group. For young-old adults (65−74), locomotor capacity had the greatest impact (OR = 4.19, 95% CI: 2.02–8.67), followed by psychological capacity (OR = 3.68, 95% CI: 2.33–5.82) and vitality (OR = 2.14, 95% CI: 1.11–4.16). In the oldest adults (75+), vitality became particularly important (OR = 4.17, 95% CI: 2.22–7.84), alongside with psychological capacity (OR = 3.15, 95% CI: 2.18–4.56) and locomotor capacity (OR = 2.20, 95% CI: 1.52–3.17).

Conclusions

Age-specific patterns suggest targeted interventions: mental health support for middle-aged adults, mobility preservation for young-old adults, and vitality enhancement for the oldest adults. These findings provide guidance for age-tailored ICOPE strategies.

背景：世界卫生组织的老年人综合护理框架强调内在能力（IC）评估，但不同年龄组的特定内在能力损伤与自评健康（SRH）之间的关系仍然没有充分表征。目的：利用台湾老龄化纵向研究资料，在调整人口统计学、社会经济和健康因素后，分析六个IC域与自评健康之间的年龄相关性。方法：我们提取了3330名自评健康状况良好或较差的参与者，分为三个年龄组：55-64岁（n = 1,278）、65-74岁（n = 1,011）和75岁以上（n = 1,041）。五个顺序逻辑回归模型评估了IC损伤（运动能力、活力、视觉、听觉、认知、心理能力）与自评健康之间的关系，调整了性别、教育、婚姻状况、就业、经济满意度、慢性病、吸烟、饮酒、体育锻炼和睡眠质量。结果：IC损伤患病率随年龄增加：55 ~ 64岁为17.2%，65 ~ 74岁为38.2%，75岁以上为61.5%。调整后，出现了与不良自我评价健康相关的IC损伤的年龄特异性模式。在中年人（55-64岁）中，运动能力与自我评价健康状况不佳的相关性最强（OR = 14.61, 95% CI: 3.50-61.01），尽管较宽的置信区间反映了较低的损害发生率。因此，心理能力（OR = 5.96, 95% CI: 3.32-10.69）可能是与该年龄组自我评价健康状况不佳相关的最主要的IC损伤。对于65-74岁的年轻老年人，运动能力的影响最大（OR = 4.19, 95% CI: 2.02-8.67），其次是心理能力（OR = 3.68, 95% CI: 2.33-5.82）和活力（OR = 2.14, 95% CI: 1.11-4.16）。在老年人（75岁以上）中，活力变得尤为重要（OR = 4.17, 95% CI: 2.22-7.84），此外还有心理能力（OR = 3.15, 95% CI: 2.18-4.56）和运动能力（OR = 2.20, 95% CI: 1.52-3.17）。结论：针对不同年龄的模式，建议采取针对性的干预措施：中年人的心理健康支持，年轻老年人的活动能力保持，以及老年人的活力增强。这些发现为制定适合年龄的ICOPE策略提供了指导。

{"title":"Age-specific associations between intrinsic capacity impairments and self-rated health in community-dwelling adults: Insights from Taiwan longitudinal study on aging","authors":"Sheng-Ping Chu , Chi-Yun Wu , Hsi-Yu Lai , I-Tzu Chen , Lin-Chieh Meng , Chih-Kuang Liang , Ming-Yueh Chou , Wei-Ju Lee , Liang-Kung Chen , Fei-Yuan Hsiao","doi":"10.1016/j.jnha.2025.100688","DOIUrl":"10.1016/j.jnha.2025.100688","url":null,"abstract":"<div><h3>Background</h3><div>The World Health Organization's Integrated Care for Older People framework emphasizes intrinsic capacity (IC) assessment, yet the relationship between specific intrinsic capacity impairments and self-rated health (SRH) across different age groups remains inadequately characterized.</div></div><div><h3>Objectives</h3><div>To analyze age-specific associations between six IC domains and self-rated health using Taiwan Longitudinal Study on Aging data, adjusting for demographic, socioeconomic, and health factors.</div></div><div><h3>Methods</h3><div>We extracted 3,330 participants with good or poor self-rated health, stratified into three age groups: 55−64 years (n = 1,278), 65−74 years (n = 1,011), and 75+ years (n = 1,041). Five sequential logistic regression models assessed associations between IC impairments (locomotor capacity, vitality, vision, hearing, cognition, psychological capacity) and self-rated health, adjusting for sex, education, marital status, employment, economic satisfaction, chronic conditions, smoking, drinking, physical exercise, and sleep quality.</div></div><div><h3>Results</h3><div>IC impairment prevalence increased with age: 17.2% (55−64), 38.2% (65−74), and 61.5% (75+). After adjustment, age-specific patterns of IC impairments associated with poor self-rated health emerged. In middle-aged adults (55−64), locomotor capacity showed the strongest association with poor self-rated health (OR = 14.61, 95% CI: 3.50–61.01), though the wide confidence interval reflects the low prevalence of impairment. Psychological capacity (OR = 5.96, 95% CI: 3.32–10.69) could thus be the most dominant IC impairment that is linked to poor self-rated health in this age group. For young-old adults (65−74), locomotor capacity had the greatest impact (OR = 4.19, 95% CI: 2.02–8.67), followed by psychological capacity (OR = 3.68, 95% CI: 2.33–5.82) and vitality (OR = 2.14, 95% CI: 1.11–4.16). In the oldest adults (75+), vitality became particularly important (OR = 4.17, 95% CI: 2.22–7.84), alongside with psychological capacity (OR = 3.15, 95% CI: 2.18–4.56) and locomotor capacity (OR = 2.20, 95% CI: 1.52–3.17).</div></div><div><h3>Conclusions</h3><div>Age-specific patterns suggest targeted interventions: mental health support for middle-aged adults, mobility preservation for young-old adults, and vitality enhancement for the oldest adults. These findings provide guidance for age-tailored ICOPE strategies.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100688"},"PeriodicalIF":4.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to the Japanese Diet is Associated with Lower Risk of Geriatric Depression: A Prospective-Cohort Study Based on the New Integrated Suburban Seniority Investigation (NISSIN) Project 坚持日本饮食与降低老年抑郁症风险相关：一项基于新综合郊区年资调查（nisin）项目的前瞻性队列研究。

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-29 DOI: 10.1016/j.jnha.2025.100689

Ho Chen , Eri Maeda , Wen Hao , Kenji Wakai , Satoe Okabayashi , Shigekazu Ukawa , Akiko Tamakoshi

Objectives

Geriatric depression is an increasingly important public health issue in an aging society. However, while Japan boasts one of the world’s highest and healthiest life expectancies at birth, there was no prospective cohort study dedicated to the specific association between the Japanese diet and geriatric depression. Thus, we aimed to examine this relationship and assess whether such association extends beyond better physical health secondary to higher diet quality.

Design, setting, participants, and measurements

Our study utilized the New Integrated Suburban Seniority Investigation (NISSIN) Project, which is an age-specific prospective cohort study that recruited residents of Nisshin City, Japan who were about to reach 65 years of age between 1996 and 2005. We measured the adherence to the Japanese diet of 1620 elderly Japanese individuals (827 male and 793 female) with a modified version of the Japanese Diet Index (JDI) and assessed the development of geriatric depression with the Geriatric Depression Scale 15 items questionnaire when they reached 70 years of age.

Results

A total of 135 individuals developed geriatric depression at 70 years of age. After adjusting for major confounding factors, those within the highest group of adherence to the Japanese diet had significantly reduced risk of developing geriatric depression (adjusted odds ratio [aOR] = 0.525, 95% confidence interval [CI]: 0.286 – 0.962) when compared to those with the lowest adherence, and each point received on the JDI was also associated with reduced risk of geriatric depression (aOR = 0.900, 95% CI: 0.816−0.992). Dietary item-wise analyses showed that fish and shellfish (p = 0.024), green-yellow vegetable (p = 0.003), and soybean-derived products (p = 0.001) were significantly associated with lower risk of geriatric depression.

Conclusion

Adherence to the Japanese diet, especially those rich in green-yellow vegetables, soybean-derived products, and fish and shellfish, may be protective against geriatric depression.

目的：老年抑郁症是老龄化社会日益重要的公共卫生问题。然而，尽管日本是世界上出生时预期寿命最高、最健康的国家之一，但没有一项前瞻性队列研究专门研究日本饮食与老年抑郁症之间的具体联系。因此，我们的目的是研究这种关系，并评估这种联系是否超出了更好的身体健康，其次是更高的饮食质量。设计、设置、参与者和测量：我们的研究利用了新综合郊区年事调查（nisin）项目，这是一项年龄特定的前瞻性队列研究，招募了1996年至2005年间日本日新市65岁以上的居民。采用修正版日本饮食指数（JDI）测量了1620名日本老年人（男性827名，女性793名）对日本饮食的依从性，并使用老年抑郁量表15项问卷评估了他们在70岁时的老年抑郁发展情况。结果：共有135人在70岁时患上老年抑郁症。在对主要混杂因素进行校正后，与依从性最低的组相比，坚持日本饮食的最高组患老年抑郁症的风险显著降低（调整优势比[aOR] = 0.525, 95%可信区间[CI]: 0.286 - 0.962）， JDI的每一分也与降低老年抑郁症的风险相关（aOR = 0.900, 95% CI: 0.816-0.992）。饮食项目分析显示，鱼类和贝类（p = 0.024）、黄绿色蔬菜（p = 0.003）和大豆衍生产品（p = 0.001）与老年抑郁症风险降低显著相关。结论：坚持日本饮食，特别是那些富含黄绿色蔬菜、大豆制品、鱼类和贝类的饮食，可能对老年抑郁症有保护作用。

{"title":"Adherence to the Japanese Diet is Associated with Lower Risk of Geriatric Depression: A Prospective-Cohort Study Based on the New Integrated Suburban Seniority Investigation (NISSIN) Project","authors":"Ho Chen , Eri Maeda , Wen Hao , Kenji Wakai , Satoe Okabayashi , Shigekazu Ukawa , Akiko Tamakoshi","doi":"10.1016/j.jnha.2025.100689","DOIUrl":"10.1016/j.jnha.2025.100689","url":null,"abstract":"<div><h3>Objectives</h3><div>Geriatric depression is an increasingly important public health issue in an aging society. However, while Japan boasts one of the world’s highest and healthiest life expectancies at birth, there was no prospective cohort study dedicated to the specific association between the Japanese diet and geriatric depression. Thus, we aimed to examine this relationship and assess whether such association extends beyond better physical health secondary to higher diet quality.</div></div><div><h3>Design, setting, participants, and measurements</h3><div>Our study utilized the New Integrated Suburban Seniority Investigation (NISSIN) Project, which is an age-specific prospective cohort study that recruited residents of Nisshin City, Japan who were about to reach 65 years of age between 1996 and 2005. We measured the adherence to the Japanese diet of 1620 elderly Japanese individuals (827 male and 793 female) with a modified version of the Japanese Diet Index (JDI) and assessed the development of geriatric depression with the Geriatric Depression Scale 15 items questionnaire when they reached 70 years of age.</div></div><div><h3>Results</h3><div>A total of 135 individuals developed geriatric depression at 70 years of age. After adjusting for major confounding factors, those within the highest group of adherence to the Japanese diet had significantly reduced risk of developing geriatric depression (adjusted odds ratio [aOR] = 0.525, 95% confidence interval [CI]: 0.286 – 0.962) when compared to those with the lowest adherence, and each point received on the JDI was also associated with reduced risk of geriatric depression (aOR = 0.900, 95% CI: 0.816−0.992). Dietary item-wise analyses showed that fish and shellfish (p = 0.024), green-yellow vegetable (p = 0.003), and soybean-derived products (p = 0.001) were significantly associated with lower risk of geriatric depression.</div></div><div><h3>Conclusion</h3><div>Adherence to the Japanese diet, especially those rich in green-yellow vegetables, soybean-derived products, and fish and shellfish, may be protective against geriatric depression.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100689"},"PeriodicalIF":4.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic determinants of sarcopenia incidence: A 14-year prospective study of 33,797 participants 肌肉减少症发病率的代谢组学决定因素：一项为期14年的前瞻性研究，33,797名参与者

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-26 DOI: 10.1016/j.jnha.2025.100668

Ha-Na Kim , John C. Newman , Ji Hyun Lee , Yun-Ah Lee , Yuji Jeong , Se-Hong Kim

Objectives

Sarcopenia, an age-related loss of skeletal muscle mass and strength, increases the risk of adverse health outcomes and socioeconomic burden; however, the metabolic causes of sarcopenia are unclear. This study investigated the association between plasma metabolites and incident sarcopenia and evaluated their predictive value for the incidence of sarcopenia.

Methods

This prospective cohort study included 33,797 participants aged 40–69 years from the UK Biobank who were free of sarcopenia and had plasma metabolomic data available. Plasma metabolite levels, including amino acids, fatty acids, lipid/lipoprotein subclasses, creatinine, and glycoprotein acetyls, were measured using nuclear magnetic resonance-based profiling. Incident sarcopenia was defined using the ICD-10 codes or criteria for low skeletal muscle mass and muscle strength.

Results

During a follow-up period of over 14 years, 829 participants developed sarcopenia. Of the 249 metabolites tested, 38 were significantly associated with the incidence of sarcopenia. The area under the ROC curve (AUC) of sarcopenia incidence for the 38 metabolites was 0.696 (95% CI: 0.666–0.726), and the AUC for conventional risk factors was 0.738–0.892, according to the models. The combined model, which integrated conventional risk factors and metabolites, significantly improved prediction (AUC: 0.779–0.898).

Conclusions

This study identified 38 plasma metabolites associated with incident sarcopenia. Incorporating these metabolites into models with conventional risk factors yielded statistically significant improvements in prediction beyond that of conventional factors alone; however, the gain was modest, and its clinical relevance remains to be determined. These findings suggest that although the clinical utility of these metabolites for predicting sarcopenia incidence has not yet been fully established, they may nevertheless provide insights into underlying biological pathways and could contribute to the development of preventive or therapeutic strategies in geriatric care.

骨骼肌减少症是一种与年龄相关的骨骼肌质量和力量损失，增加了不良健康结果和社会经济负担的风险；然而，肌肉减少症的代谢原因尚不清楚。本研究探讨血浆代谢物与肌少症发病率之间的关系，并评估其对肌少症发病率的预测价值。方法：这项前瞻性队列研究包括33797名年龄在40-69岁之间的参与者，他们来自英国生物银行，没有肌肉减少症，并且有血浆代谢组学数据。血浆代谢物水平，包括氨基酸、脂肪酸、脂质/脂蛋白亚类、肌酐和糖蛋白乙酰，使用基于核磁共振的谱分析测量。使用ICD-10代码或低骨骼肌质量和肌肉力量标准定义偶发性肌肉减少症。结果在超过14年的随访期间，829名参与者患上了肌肉减少症。在所检测的249种代谢物中，有38种与肌肉减少症的发病率显著相关。根据模型，38种代谢物的肌少症发生率的ROC曲线下面积（AUC）为0.696 (95% CI: 0.666-0.726)，常规危险因素的AUC为0.738-0.892。综合了传统危险因素和代谢物的联合模型显著提高了预测效果（AUC: 0.779-0.898）。结论：本研究确定了38种血浆代谢物与肌少症相关。将这些代谢物纳入具有常规危险因素的模型中，在预测方面取得了统计学上显著的改善，优于单独使用常规因素；然而，获益是适度的，其临床相关性仍有待确定。这些发现表明，尽管这些代谢物在预测肌肉减少症发病率方面的临床应用尚未完全确定，但它们可能为潜在的生物学途径提供了见解，并有助于制定老年护理的预防或治疗策略。

{"title":"Metabolomic determinants of sarcopenia incidence: A 14-year prospective study of 33,797 participants","authors":"Ha-Na Kim , John C. Newman , Ji Hyun Lee , Yun-Ah Lee , Yuji Jeong , Se-Hong Kim","doi":"10.1016/j.jnha.2025.100668","DOIUrl":"10.1016/j.jnha.2025.100668","url":null,"abstract":"<div><h3>Objectives</h3><div>Sarcopenia, an age-related loss of skeletal muscle mass and strength, increases the risk of adverse health outcomes and socioeconomic burden; however, the metabolic causes of sarcopenia are unclear. This study investigated the association between plasma metabolites and incident sarcopenia and evaluated their predictive value for the incidence of sarcopenia.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 33,797 participants aged 40–69 years from the UK Biobank who were free of sarcopenia and had plasma metabolomic data available. Plasma metabolite levels, including amino acids, fatty acids, lipid/lipoprotein subclasses, creatinine, and glycoprotein acetyls, were measured using nuclear magnetic resonance-based profiling. Incident sarcopenia was defined using the ICD-10 codes or criteria for low skeletal muscle mass and muscle strength.</div></div><div><h3>Results</h3><div>During a follow-up period of over 14 years, 829 participants developed sarcopenia. Of the 249 metabolites tested, 38 were significantly associated with the incidence of sarcopenia. The area under the ROC curve (AUC) of sarcopenia incidence for the 38 metabolites was 0.696 (95% CI: 0.666–0.726), and the AUC for conventional risk factors was 0.738–0.892, according to the models. The combined model, which integrated conventional risk factors and metabolites, significantly improved prediction (AUC: 0.779–0.898).</div></div><div><h3>Conclusions</h3><div>This study identified 38 plasma metabolites associated with incident sarcopenia. Incorporating these metabolites into models with conventional risk factors yielded statistically significant improvements in prediction beyond that of conventional factors alone; however, the gain was modest, and its clinical relevance remains to be determined. These findings suggest that although the clinical utility of these metabolites for predicting sarcopenia incidence has not yet been fully established, they may nevertheless provide insights into underlying biological pathways and could contribute to the development of preventive or therapeutic strategies in geriatric care.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100668"},"PeriodicalIF":4.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition for Healthy Longevity 健康长寿的营养

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-26 DOI: 10.1016/j.jnha.2025.100691

Natasha Grande de França , João Valentini Neto

引用次数: 0

Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates prausnitzii粪杆菌表明非人灵长类动物的健康寿命和寿命

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-23 DOI: 10.1016/j.jnha.2025.100690

Kylie Kavanagh , Taylor Sheridan , Ravichandra Vemuri , Aleaya Bowie , Darla DeStephanis , Shannon Kraniak , Elizabeth Burner , McKinley Santiago

Objective

To assess the relationship between fecal Faecalibacterium prausnitzii and health resiliency.

Design

Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of Faecalibacterium prausnitzii.

Setting

Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.

Participants

Old world male and female nonhuman primates.

Measurements

Age, weight, glycemic indices, fecal total microbial loads and specific detection Faecalibacterium prausnitzii levels as measured by whole genome sequencing or polymerase chain reaction.

Results

Higher levels of fecal Faecalibacterium prausnitzii was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered Faecalibacterium prausnitzii levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).

Conclusion

The abundance of the intestinal microbial species Faecalibacterium prausnitzii appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.

目的探讨粪便中prausnitzfaecalibacterium与健康恢复力的关系。设计在疾病发生前对非人类灵长类动物的粪便中prausnitzii粪杆菌的丰度进行评估。辐射诱发的和自发产生的年龄诱发的发病率和死亡率，包括2型糖尿病的高发病率。参与者来自世界雄性和雌性非人类灵长类动物。测量方法：sage、体重、血糖指数、粪便总微生物负荷及特异检测，采用全基因组测序或聚合酶链反应测定prausnitzii粪杆菌水平。结果在全身照射后存活的非人类灵长类动物粪便中观察到较高水平的prausnitzii粪杆菌，它们的寿命更长，并且可以保护它们免受未来2型糖尿病的诊断。2型糖尿病的发展进一步降低了prausnitzii粪杆菌的水平。粪便丰度差异的平均效应大小为1.76（95%可信区间为0.03-3.50）。结论prausnitzii粪杆菌（Faecalibacterium prausnitzii）肠道微生物物种的丰度似乎是一个强有力的候选生物标志物物种，预示着优越的健康弹性和相关寿命。

{"title":"Faecalibacterium prausnitzii Indicates Healthspan and Lifespan in Nonhuman Primates","authors":"Kylie Kavanagh , Taylor Sheridan , Ravichandra Vemuri , Aleaya Bowie , Darla DeStephanis , Shannon Kraniak , Elizabeth Burner , McKinley Santiago","doi":"10.1016/j.jnha.2025.100690","DOIUrl":"10.1016/j.jnha.2025.100690","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the relationship between fecal <em>Faecalibacterium prausnitzii</em> and health resiliency.</div></div><div><h3>Design</h3><div>Cohorts of nonhuman primates were evaluated prior to disease development for fecal abundances of <em>Faecalibacterium prausnitzii.</em></div></div><div><h3>Setting</h3><div>Radiation-induced and spontaneously arising age-induced morbidity and mortality, including high rates of Type 2 diabetes.</div></div><div><h3>Participants</h3><div>Old world male and female nonhuman primates.</div></div><div><h3>Measurements</h3><div>Age, weight, glycemic indices, fecal total microbial loads and specific detection <em>Faecalibacterium prausnitzii</em> levels as measured by whole genome sequencing or polymerase chain reaction.</div></div><div><h3>Results</h3><div>Higher levels of fecal <em>Faecalibacterium prausnitzii</em> was observed in nonhuman primates that survived whole body irradiation, had longer lifespans, and were protected from future Type 2 diabetes diagnoses. Type 2 diabetes development further lowered <em>Faecalibacterium prausnitzii</em> levels. The mean effect size for differences in fecal abundance was 1.76 (95% confidence interval 0.03–3.50).</div></div><div><h3>Conclusion</h3><div>The abundance of the intestinal microbial species <em>Faecalibacterium prausnitzii</em> appears to be a strong candidate biomarker species for a preferred microbiome that predicts superior health resiliency and associated lifespan.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100690"},"PeriodicalIF":4.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linking social support network deficits to late-life malnutrition: The hidden psychological pathway 将社会支持网络缺陷与晚年营养不良联系起来：隐藏的心理途径

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-22 DOI: 10.1016/j.jnha.2025.100686

Miao Miao, Yu Zhou, Chen Qiu, Doris Sau Fung Yu

Objectives

Social and mental health significantly influence the nutritional status of older adults. While a relationship exists between social support network deficits and malnutrition, the underlying mechanisms remain unclear. This study aims to explore the associations and potential psychological pathways among social support network deficits, depressive symptoms, and malnutrition in older adults.

Methods

A secondary analysis was conducted using data from the Jockey Club Pathway to Healthy Aging project, collected between May 2022 and June 2024. Structural equation modeling was employed to examine the relationships among social support network deficits, depressive symptoms, and malnutrition, as well as the mediating role of depressive symptoms in the overall participants and across body mass index subgroups.

Results

The study included 5,286 older adults, with an undernourishment prevalence of 14.8%. Social support network deficits (β = −0.044, p = 0.004) and depressive symptoms (β = −0.150, p < 0.001) were significantly negatively associated with malnutrition scores, with depressive symptoms mediating 55.1% of the total effect (β = −0.098, p < 0.001). Depressive symptoms acted as a complete mediator in the normal weight group, while it served as a partial mediator in the overweight and obese groups.

Conclusions

The risk of malnutrition in older adults is associated with social support network deficits and depressive symptoms. Preventive strategies should differ based on body mass index, focusing on social factors for overweight and obese individuals while addressing negative emotions in those with normal weight to encourage healthy dietary habits and lifestyles.

目的社会和心理健康对老年人营养状况有显著影响。虽然社会支持网络缺陷与营养不良之间存在关系，但其潜在机制尚不清楚。本研究旨在探讨老年人社会支持网络缺陷、抑郁症状和营养不良之间的联系和潜在的心理途径。方法利用赛马会健康老龄化路径项目的数据进行二次分析，收集时间为2022年5月至2024年6月。采用结构方程模型检验社会支持网络缺失、抑郁症状和营养不良之间的关系，以及抑郁症状在整体参与者和跨体重指数亚组中的中介作用。结果该研究包括5286名老年人，营养不良患病率为14.8%。社会支持网络缺陷（β = - 0.044, p = 0.004）和抑郁症状（β = - 0.150, p < 0.001）与营养不良评分呈显著负相关，其中抑郁症状介导了总效应的55.1% （β = - 0.098, p < 0.001）。抑郁症状在正常体重组中起完全中介作用，而在超重和肥胖组中起部分中介作用。结论老年人营养不良风险与社会支持网络缺失和抑郁症状相关。预防策略应根据体重指数的不同而有所不同，重点关注超重和肥胖个体的社会因素，同时解决体重正常人群的负面情绪，鼓励健康的饮食习惯和生活方式。

{"title":"Linking social support network deficits to late-life malnutrition: The hidden psychological pathway","authors":"Miao Miao, Yu Zhou, Chen Qiu, Doris Sau Fung Yu","doi":"10.1016/j.jnha.2025.100686","DOIUrl":"10.1016/j.jnha.2025.100686","url":null,"abstract":"<div><h3>Objectives</h3><div>Social and mental health significantly influence the nutritional status of older adults. While a relationship exists between social support network deficits and malnutrition, the underlying mechanisms remain unclear. This study aims to explore the associations and potential psychological pathways among social support network deficits, depressive symptoms, and malnutrition in older adults.</div></div><div><h3>Methods</h3><div>A secondary analysis was conducted using data from the Jockey Club Pathway to Healthy Aging project, collected between May 2022 and June 2024. Structural equation modeling was employed to examine the relationships among social support network deficits, depressive symptoms, and malnutrition, as well as the mediating role of depressive symptoms in the overall participants and across body mass index subgroups.</div></div><div><h3>Results</h3><div>The study included 5,286 older adults, with an undernourishment prevalence of 14.8%. Social support network deficits (β = −0.044, <em>p</em> = 0.004) and depressive symptoms (β = −0.150, <em>p</em> < 0.001) were significantly negatively associated with malnutrition scores, with depressive symptoms mediating 55.1% of the total effect (β = −0.098, <em>p</em> < 0.001). Depressive symptoms acted as a complete mediator in the normal weight group, while it served as a partial mediator in the overweight and obese groups.</div></div><div><h3>Conclusions</h3><div>The risk of malnutrition in older adults is associated with social support network deficits and depressive symptoms. Preventive strategies should differ based on body mass index, focusing on social factors for overweight and obese individuals while addressing negative emotions in those with normal weight to encourage healthy dietary habits and lifestyles.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100686"},"PeriodicalIF":4.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between omega-3 fatty acid intake and risk of diabetic retinopathy: A systematic review and meta-analysis omega-3脂肪酸摄入与糖尿病视网膜病变风险之间的关系：一项系统综述和荟萃分析

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-22 DOI: 10.1016/j.jnha.2025.100632

Kai-Yang Chen , Hoi-Chun Chan , Chi-Ming Chan

Background

Diabetic Retinopathy is a significant microvascular complication of diabetes mellitus characterized by progressive damage to the retinal vasculature. Current management strategies focus on modifying risk factors and treating established disease. Omega-3 polyunsaturated fatty acids (PUFAs) demonstrate anti-inflammatory, antioxidative, and vasculoprotective properties.

Objectives

To evaluate the protective effects of omega-3 fatty acids on DR incidence, progression, and microvascular health across diverse diabetic populations.

Methods

A comprehensive literature search was conducted via PubMed, EBSCO Open Research, ScienceDirect, Wiley Online Library, and Google Scholar. A reviewer screened the potential articles against prespecified eligibility criteria. The risk of bias in the eligible studies was then evaluated using the Newcastle Ottawa Scale (NOS), a Risk of Bias visualization tool developed by the Cochrane Collaboration (ROB 2.0). Data were then systematically extracted and analyzed.

Results

Fourteen studies involving 139,879 participants were analyzed. Omega-3 fatty acid intake of ≥500 mg/day significantly reduced the risk of sight-threatening diabetic retinopathy (DR) by 48% (HR = 0.52; 95% CI: 0.31–0.88; p = 0.001). Subgroup meta-analysis showed a stronger associated protective effect in type 2 diabetes (T2D) compared to type 1 (T1D), with a pooled hazard ratio of 0.71 (log HR = −0.339; SE = 0.0667; p < 0.000001). The antioxidant benefits were linked by a pooled mean difference of −1.399 in oxidative stress markers (MDA/TBARS) (95% CI: −1.432 to −1.366; Z = 83.29; p < 0.00001), with no significant heterogeneity (I² = 0%). Further stratification showed robust effects in both RCTs (HR = 0.743; p = 0.002) and non-RCTs (HR = 0.514; p = 0.005). These findings support omega-3s—especially in T2D—as a non-pharmacologic intervention for DR prevention, likely through anti-inflammatory and vasoprotective mechanisms.

Conclusion

Omega-3 fatty acid intake is associated with dose-dependent protection against diabetic retinopathy, with the greatest benefits from whole food sources, optimal omega-6/omega-3 ratios, and in well-controlled T2D patients.

背景：糖尿病视网膜病变是糖尿病的一种重要的微血管并发症，其特征是视网膜血管的进行性损害。目前的管理战略侧重于改变危险因素和治疗既定疾病。Omega-3多不饱和脂肪酸（PUFAs）具有抗炎、抗氧化和血管保护特性。目的评价omega-3脂肪酸对不同糖尿病人群DR发病、进展和微血管健康的保护作用。方法通过PubMed、EBSCO Open Research、ScienceDirect、Wiley Online Library和b谷歌Scholar进行综合文献检索。审稿人根据预先规定的资格标准筛选潜在的文章。然后使用纽卡斯尔渥太华量表（NOS）评估符合条件的研究的偏倚风险，这是一种由Cochrane协作（ROB 2.0）开发的偏倚风险可视化工具。然后系统地提取和分析数据。结果14项研究共纳入139,879名受试者。ω -3脂肪酸摄入量≥500毫克/天显著降低48%的视力威胁糖尿病视网膜病变（DR）的风险（HR = 0.52; 95% CI: 0.31-0.88; p = 0.001）。亚组荟萃分析显示，与1型糖尿病（T1D）相比，2型糖尿病（T2D）的相关保护作用更强，合并风险比为0.71 （log HR = - 0.339; SE = 0.0667; p < 0.000001）。氧化应激标志物（MDA/TBARS）的合并平均差异为- 1.399 (95% CI: - 1.432至- 1.366;Z = 83.29; p < 0.00001)，无显著异质性（I²= 0%）。进一步分层在rct （HR = 0.743; p = 0.002）和非rct （HR = 0.514; p = 0.005）中均显示出强大的效果。这些发现支持omega-3作为预防DR的非药物干预，特别是在t2d中，可能通过抗炎和血管保护机制。结论：omega-3脂肪酸摄入与预防糖尿病视网膜病变的剂量依赖性保护有关，在全食物来源、最佳omega-6/omega-3比例和控制良好的T2D患者中获益最大。

{"title":"Association between omega-3 fatty acid intake and risk of diabetic retinopathy: A systematic review and meta-analysis","authors":"Kai-Yang Chen , Hoi-Chun Chan , Chi-Ming Chan","doi":"10.1016/j.jnha.2025.100632","DOIUrl":"10.1016/j.jnha.2025.100632","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic Retinopathy is a significant microvascular complication of diabetes mellitus characterized by progressive damage to the retinal vasculature. Current management strategies focus on modifying risk factors and treating established disease. Omega-3 polyunsaturated fatty acids (PUFAs) demonstrate anti-inflammatory, antioxidative, and vasculoprotective properties.</div></div><div><h3>Objectives</h3><div>To evaluate the protective effects of omega-3 fatty acids on DR incidence, progression, and microvascular health across diverse diabetic populations.</div></div><div><h3>Methods</h3><div>A comprehensive literature search was conducted via PubMed, EBSCO Open Research, ScienceDirect, Wiley Online Library, and Google Scholar. A reviewer screened the potential articles against prespecified eligibility criteria. The risk of bias in the eligible studies was then evaluated using the Newcastle Ottawa Scale (NOS), a Risk of Bias visualization tool developed by the Cochrane Collaboration (ROB 2.0). Data were then systematically extracted and analyzed.</div></div><div><h3>Results</h3><div>Fourteen studies involving 139,879 participants were analyzed. Omega-3 fatty acid intake of ≥500 mg/day significantly reduced the risk of sight-threatening diabetic retinopathy (DR) by 48% (HR = 0.52; 95% CI: 0.31–0.88; p = 0.001). Subgroup meta-analysis showed a stronger associated protective effect in type 2 diabetes (T2D) compared to type 1 (T1D), with a pooled hazard ratio of 0.71 (log HR = −0.339; SE = 0.0667; p < 0.000001). The antioxidant benefits were linked by a pooled mean difference of −1.399 in oxidative stress markers (MDA/TBARS) (95% CI: −1.432 to −1.366; Z = 83.29; p < 0.00001), with no significant heterogeneity (I² = 0%). Further stratification showed robust effects in both RCTs (HR = 0.743; p = 0.002) and non-RCTs (HR = 0.514; p = 0.005). These findings support omega-3s—especially in T2D—as a non-pharmacologic intervention for DR prevention, likely through anti-inflammatory and vasoprotective mechanisms.</div></div><div><h3>Conclusion</h3><div>Omega-3 fatty acid intake is associated with dose-dependent protection against diabetic retinopathy, with the greatest benefits from whole food sources, optimal omega-6/omega-3 ratios, and in well-controlled T2D patients.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 10","pages":"Article 100632"},"PeriodicalIF":4.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition disorders and related conditions—Prevalence, overlap and relation to one year survival in geriatric patients 营养失调及相关疾病：老年患者的患病率、重叠及与一年生存率的关系

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-20 DOI: 10.1016/j.jnha.2025.100682

Frida Ostonen Peelen , Maria Enge , Rikke Lundsgaard Nielsen , Anne Marie Beck , Ann Ödlund Olin , Tommy Cederholm , Anne-Marie Boström , Ingvild Paur

Objectives

To investigate the overlap between the nutrition disorders (malnutrition, low-intake dehydration, obesity) and nutrition related conditions (frailty, sarcopenia, sarcopenic obesity), and the significance of each of these and their combinations for survival among older patients admitted to geriatric care.

Methods

This exploratory study was based on a cross-sectional study with 100 patients (≥65 years) admitted to two geriatric departments. Data was retrieved from the Electronic Patient Record. Malnutrition was defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria with no prior screening. A low-intake dehydration equation, using proxy urea, was applied. Obesity was diagnosed at BMI > 29.9 kg/m². Frailty was assessed by Clinical Frailty Scale, whereas sarcopenia was diagnosed according to the European Working Group of Sarcopenia in Older People (EWGSOP2). Sarcopenic obesity was defined as the combination of sarcopenia and obesity. Mortality was recorded up to one year after discharge.

Main findings

The nutrition disorders and nutrition related conditions displayed considerable overlaps, and the prevalences were; frailty 67%, low-intake dehydration 62%, malnutrition 58%, sarcopenia 30%, obesity 13%, and sarcopenic obesity 0%. Higher numbers of nutrition disorders and nutrition related conditions combined, and malnutrition (according to GLIM) alone, were related to decreased one-year survival as show in Kaplan Meier plots.

Conclusion

The prevalence and overlap of the nutrition disorders; malnutrition, and low-intake dehydration and the nutrition related conditions; frailty and sarcopenia were high in patients acutely admitted to geriatric departments. Increasing number of nutrition disorders and nutrition related conditions combined, and malnutrition alone were associated with decreased survival.

目的探讨营养失调（营养不良、低摄入量脱水、肥胖）和营养相关疾病（虚弱、肌肉减少症、肌肉减少性肥胖）之间的重叠，以及这些疾病及其组合对老年患者生存的意义。方法本探索性研究基于一项横断面研究，纳入了两个老年科收治的100例患者（≥65岁）。数据从电子病历中检索。营养不良是根据全球营养不良领导倡议（GLIM）标准定义的，没有事先筛查。采用替代尿素的低进食量脱水方程。BMI >； 29.9 kg/m2诊断为肥胖。虚弱是通过临床虚弱量表评估的，而肌肉减少症是根据欧洲老年人肌肉减少症工作组（EWGSOP2）诊断的。肌少性肥胖被定义为肌少症和肥胖的结合。出院后一年的死亡率均有记录。主要发现：营养失调与营养相关疾病存在一定的重叠，患病率为：虚弱67%，低摄入量脱水62%，营养不良58%，肌肉减少30%，肥胖13%，肌肉减少型肥胖0%。Kaplan Meier图显示，较高数量的营养失调和营养相关疾病，以及单独的营养不良（根据GLIM），与一年生存率下降有关。结论营养失调的患病率和重叠性；营养不良、低摄入量脱水及与营养有关的情况；老年急诊科患者虚弱和肌肉减少率较高。营养失调和营养相关疾病的数量增加，以及单独的营养不良与生存率下降有关。

{"title":"Nutrition disorders and related conditions—Prevalence, overlap and relation to one year survival in geriatric patients","authors":"Frida Ostonen Peelen , Maria Enge , Rikke Lundsgaard Nielsen , Anne Marie Beck , Ann Ödlund Olin , Tommy Cederholm , Anne-Marie Boström , Ingvild Paur","doi":"10.1016/j.jnha.2025.100682","DOIUrl":"10.1016/j.jnha.2025.100682","url":null,"abstract":"<div><h3>Objectives</h3><div>To investigate the overlap between the nutrition disorders (malnutrition, low-intake dehydration, obesity) and nutrition related conditions (frailty, sarcopenia, sarcopenic obesity), and the significance of each of these and their combinations for survival among older patients admitted to geriatric care.</div></div><div><h3>Methods</h3><div>This exploratory study was based on a cross-sectional study with 100 patients (≥65 years) admitted to two geriatric departments. Data was retrieved from the Electronic Patient Record. Malnutrition was defined according to the Global Leadership Initiative on Malnutrition (GLIM) criteria with no prior screening. A low-intake dehydration equation, using proxy urea, was applied. Obesity was diagnosed at BMI > 29.9 kg/m<sup>2</sup>. Frailty was assessed by Clinical Frailty Scale, whereas sarcopenia was diagnosed according to the European Working Group of Sarcopenia in Older People (EWGSOP2). Sarcopenic obesity was defined as the combination of sarcopenia and obesity. Mortality was recorded up to one year after discharge.</div></div><div><h3>Main findings</h3><div>The nutrition disorders and nutrition related conditions displayed considerable overlaps, and the prevalences were; frailty 67%, low-intake dehydration 62%, malnutrition 58%, sarcopenia 30%, obesity 13%, and sarcopenic obesity 0%. Higher numbers of nutrition disorders and nutrition related conditions combined, and malnutrition (according to GLIM) alone, were related to decreased one-year survival as show in Kaplan Meier plots.</div></div><div><h3>Conclusion</h3><div>The prevalence and overlap of the nutrition disorders; malnutrition, and low-intake dehydration and the nutrition related conditions; frailty and sarcopenia were high in patients acutely admitted to geriatric departments. Increasing number of nutrition disorders and nutrition related conditions combined, and malnutrition alone were associated with decreased survival.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100682"},"PeriodicalIF":4.0,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Frequent Ramen consumption and increased mortality risk in specific subgroups: A Yamagata cohort study” [J Nutr Health Aging, 29 (2025) 100643] “经常吃拉面与特定亚组死亡风险增加：一项Yamagata队列研究”[J] .营养学与老龄化，29(2025)100643。

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-20 DOI: 10.1016/j.jnha.2025.100684

Miho Suzuki , Natsuko Suzuki , Ri Sho , Masayoshi Souri , Tsuneo Konta

引用次数: 0

Applicability and predictive validity of the global leadership initiative on malnutrition criteria for older patients with sepsis according to different muscle mass assessment methods 根据不同肌肉质量评估方法，全球领导力倡议对老年脓毒症患者营养不良标准的适用性和预测有效性

IF 4 3区医学 Q1 GERIATRICS & GERONTOLOGY

Journal of Nutrition Health & Aging

Pub Date : 2025-09-19 DOI: 10.1016/j.jnha.2025.100685

Na Shang , Qiujing Li , Haijing Zhou , Xiangqun Zhang , Shubin Guo , Xue Mei

Objectives

To evaluate the applicability of the Global Leadership Initiative on Malnutrition (GLIM) criteria in older patients with sepsis and to compare the predictive validity for 28-day mortality of different muscle mass assessment methods in the emergency department.

Design

Prospective cohort study.

Setting

Emergency department.

Patients

Older patients (≥65 years) with sepsis.

Measurements

Muscle mass was assessed using three methods: (1) the skeletal muscle index at the third lumbar vertebra (L3) on computed tomography (CT) scans; (2) calf circumference (CC), and (3) mid-upper-arm circumference (MAC). Cox regression analysis was performed to assess the association between the GLIM criteria and 28-day all-cause mortality. Additionally, the C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the predictive validity of the three instruments. Survival curves were assessed using the Kaplan–Meier method and compared using the log-rank test.

Results

A total of 598 patients with sepsis were included. The prevalence of malnutrition according to GLIM-CT, GLIM-CC, and GLIM-MAC was 53.3%, 63.0%, and 40.8%, respectively. Cox regression analysis revealed that the GLIM criteria were independent risk factors for all-cause 28-day mortality. Incorporation of GLIM-CT, GLIM-CC, or GLIM-MAC into a base model significantly improved the C-statistic. The model including GLIM-CT had the highest C-statistic, improving the C-statistic of the base model from 0.780 (95% confidence interval [CI]: 0.741−0.819) to 0.823 (95% CI: 0.789−0.857). This improvement in risk prediction was also confirmed via category-free NRI and IDI, suggesting that GLIM-CT had the best performance. Kaplan–Meier survival analysis showed that patients with malnutrition defined according to the GLIM criteria had a greater probability of 28-day mortality (log-rank, P < 0.001).

Conclusion

Malnutrition, defined via any of the three methods, was predictive of 28-day mortality among older patients with sepsis in the emergency department. GLIM-CT had the best predictive validity.

目的评价全球营养不良领导倡议（Global Leadership Initiative on nutrition， GLIM）标准在老年脓毒症患者中的适用性，并比较不同肌肉质量评估方法在急诊科对28天死亡率的预测效度。前瞻性队列研究。SettingEmergency部门。患者（≥65岁）败血症患者。测量采用三种方法评估肌肉质量：(1)计算机断层扫描（CT）第三腰椎（L3）骨骼肌指数；(2)小腿围（CC）和(3)中上臂围（MAC）。采用Cox回归分析评估GLIM标准与28天全因死亡率之间的关系。此外，采用c统计量、净重分类改善（NRI）和综合区分改善（IDI）来评估三种工具的预测效度。使用Kaplan-Meier法评估生存曲线，并使用log-rank检验进行比较。结果共纳入598例脓毒症患者。根据格利姆- ct、格利姆- cc和格利姆- mac，营养不良发生率分别为53.3%、63.0%和40.8%。Cox回归分析显示，GLIM标准是全因28天死亡率的独立危险因素。将gim - ct、gim - cc或gim - mac纳入基础模型可显著提高c统计量。包含glimm - ct的模型c -统计量最高，将基础模型的c -统计量从0.780（95%置信区间[CI]: 0.741−0.819）提高到0.823（95%置信区间[CI]: 0.789−0.857）。通过无分类NRI和IDI也证实了这种风险预测的改善，表明gim - ct具有最佳性能。Kaplan-Meier生存分析显示，根据GLIM标准定义的营养不良患者28天死亡率更高（log-rank, P < 0.001）。结论：通过三种方法中的任何一种定义的营养不良可预测急诊科老年败血症患者28天死亡率。预测效度最佳。

{"title":"Applicability and predictive validity of the global leadership initiative on malnutrition criteria for older patients with sepsis according to different muscle mass assessment methods","authors":"Na Shang , Qiujing Li , Haijing Zhou , Xiangqun Zhang , Shubin Guo , Xue Mei","doi":"10.1016/j.jnha.2025.100685","DOIUrl":"10.1016/j.jnha.2025.100685","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate the applicability of the Global Leadership Initiative on Malnutrition (GLIM) criteria in older patients with sepsis and to compare the predictive validity for 28-day mortality of different muscle mass assessment methods in the emergency department.</div></div><div><h3>Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting</h3><div>Emergency department.</div></div><div><h3>Patients</h3><div>Older patients (≥65 years) with sepsis.</div></div><div><h3>Measurements</h3><div>Muscle mass was assessed using three methods: (1) the skeletal muscle index at the third lumbar vertebra (L3) on computed tomography (CT) scans; (2) calf circumference (CC), and (3) mid-upper-arm circumference (MAC). Cox regression analysis was performed to assess the association between the GLIM criteria and 28-day all-cause mortality. Additionally, the C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the predictive validity of the three instruments. Survival curves were assessed using the Kaplan–Meier method and compared using the log-rank test.</div></div><div><h3>Results</h3><div>A total of 598 patients with sepsis were included. The prevalence of malnutrition according to GLIM-CT, GLIM-CC, and GLIM-MAC was 53.3%, 63.0%, and 40.8%, respectively. Cox regression analysis revealed that the GLIM criteria were independent risk factors for all-cause 28-day mortality. Incorporation of GLIM-CT, GLIM-CC, or GLIM-MAC into a base model significantly improved the C-statistic. The model including GLIM-CT had the highest C-statistic, improving the C-statistic of the base model from 0.780 (95% confidence interval [CI]: 0.741−0.819) to 0.823 (95% CI: 0.789−0.857). This improvement in risk prediction was also confirmed via category-free NRI and IDI, suggesting that GLIM-CT had the best performance. Kaplan–Meier survival analysis showed that patients with malnutrition defined according to the GLIM criteria had a greater probability of 28-day mortality (log-rank, <em>P</em> < 0.001).</div></div><div><h3>Conclusion</h3><div>Malnutrition, defined via any of the three methods, was predictive of 28-day mortality among older patients with sepsis in the emergency department. GLIM-CT had the best predictive validity.</div></div>","PeriodicalId":54778,"journal":{"name":"Journal of Nutrition Health & Aging","volume":"29 11","pages":"Article 100685"},"PeriodicalIF":4.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0