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2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems最新文献

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Flexible Parylene-based Microelectrode Technology for Intraocular Retinal Prostheses 基于柔性聚苯乙烯的眼内视网膜假体微电极技术
D. Rodger, Wen Li, H. Ameri, A. Ray, J. Weiland, M. Humayun, Y. Tai
We present the first single metal layer flexible microelectrode arrays designed for intraocular implantation that utilize parylene C as their primary structural and insulating material. These electrodes are fabricated as a key component of an intraocular retinal prosthesis comprising a radio-frequency coil for power and data transfer, a packaged high lead-count telemetry-recovery and driving application-specific integrated circuit (ASIC), and a high-density epiretinal stimulating microelectrode array for the treatment of retinal degenerative blindness in humans. Electrochemical tests have demonstrated that these thin-film platinum electrodes perform as necessary for neuronal stimulation. A novel bioconformal MEMS geometry for a complete intraocular system with capsular retaining-wings that enables all the components of the system to be implanted and retained within the lens capsule and vitreous cavity of the eye is also presented. The efficacy of this geometry when compared with a previous model without capsular retaining-wings has been verified by surgical implantation in animal models.
我们提出了第一个单金属层柔性微电极阵列,设计用于眼内植入,利用聚对二甲苯作为其主要结构和绝缘材料。这些电极是眼内视网膜假体的关键组成部分,包括用于电力和数据传输的射频线圈,封装的高铅计数遥测恢复和驱动专用集成电路(ASIC),以及用于治疗人类视网膜退行性失明的高密度视网膜外刺激微电极阵列。电化学测试表明,这些薄膜铂电极对神经元刺激是必要的。本文还提出了一种新的生物适形MEMS几何结构,用于具有囊状保留翼的完整眼内系统,使系统的所有组件能够植入并保留在眼睛的晶状体囊和玻璃体腔内。这种几何形状的有效性,与以前的模型相比,没有包膜保留翼已经通过手术植入动物模型进行了验证。
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引用次数: 39
Capacity Evaluation of a MEMS Based Micro Cooling Device Using Liquid Metal as Coolant 以液态金属为冷却剂的MEMS微冷却装置容量评估
Z. Deng, Jing Liu
The latest generation of gigahertz-clock-rate CPUs is becoming more challenging to fit into designs. These chips are squeezing into tighter and tighter spaces with no enough places for heat to dissipate. Meanwhile, high-capacity cooling options remain limited for many small-scale applications such as microsystems, sensors and actuators, and micro/nano electronic components. This work presents a MEMS based micro cooling device, which is comprised of an active cooling substrate embedded with fluidic cooling functionality using liquid metal, to provide direct cooling to high heat flux electronics and MEMS devices. In order to better understand the cooling capability of this MEMS-based micro cooling device, the three-dimensional heat transfer process thus involved was numerically simulated. A series of calculations with different flow rates and thermal parameters were performed. Effect of different working fluids is also investigated. The results indicate that the MEMS-based cooling device has powerful cooling capability while using liquid metal as cooling fluid, and thus allow for lower operating temperatures for electronic devices and micro/nano systems
最新一代的千兆赫时钟速率cpu正变得越来越难以适应设计。这些芯片被挤进越来越小的空间,没有足够的地方散热。同时,对于许多小型应用,如微系统、传感器和执行器以及微/纳米电子元件,高容量冷却选择仍然有限。本研究提出了一种基于MEMS的微冷却装置,该装置由嵌入液态金属流体冷却功能的主动冷却基板组成,可为高热流密度电子器件和MEMS器件提供直接冷却。为了更好地了解这种基于mems的微冷却装置的冷却能力,对其三维传热过程进行了数值模拟。在不同的流量和热参数下进行了一系列的计算。研究了不同工质的影响。结果表明,以液态金属为冷却流体的mems冷却装置具有强大的冷却能力,从而可以降低电子器件和微纳米系统的工作温度
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引用次数: 10
Design Principle of Suspension of MEMS Gyroscope MEMS陀螺仪悬架设计原理
Q. Shi, Shourong Wang, A. Qiu, Yishen Xu, Xunsheng Ji
Canceling and minimizing quadrature error is the key to improve the performance of MEMS gyroscopes. This paper addresses how to design suspension springs to decrease the quadrature error which induced with manufacture asymmetric. According to the stiffness matrix of suspension spring, the relationship among quadrature error, terms of stiffness matrix and width mismatch was put forward. The off-diagonal term which is coupled between driven and sensing directions has larger effect on the quadrature error than other off-diagonal terms of system stiffness matrix. The design principle of suspension springs of MEMS gyroscope was put forward, which is suggest that U-spring, serpentine spring and folded-flexure spring should be preferential adopted. At last, a z-axis MEMS gyroscope was improved based on the design principle, and the results of FEM simulation and experiment show the quadrature error is decreased largely
消除和减小正交误差是提高微机电系统陀螺仪性能的关键。本文讨论了如何设计悬架弹簧以减小由于制造不对称而引起的正交误差。根据悬架弹簧的刚度矩阵,提出了正交误差与刚度矩阵项和宽度失配之间的关系。驱动方向和传感方向耦合的非对角项对系统刚度矩阵的正交误差影响较大。提出了MEMS陀螺仪悬架弹簧的设计原则,建议优先采用u形弹簧、蛇形弹簧和折叠柔性弹簧。最后,根据设计原理对z轴MEMS陀螺仪进行了改进,有限元仿真和实验结果表明,该陀螺仪的正交误差大大减小
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引用次数: 12
A Novel Micro Dispensing Chip for Microarray Fabrication 用于微阵列制造的新型微点胶芯片
Baojian Xu, Zhi Qiao, Qinghui Jin, Jianlong Zhao
The paper proposes a novel design concept and fabrication method of micro dispensing chip. The filling process is performed by capillary force without extra energy, greatly reducing the complexity of design and operation. The annular interspaces around the nozzles in the chip can help the droplet formation on the hydrophilic surfaces, and the step conjunction between the channel and the reservoir can reduce the fluid refluence to the inlet. The fabrication of the silicon chip with 25 reservoirs has been successfully completed by deep reactive ion etching (DRIE). Polydimethyl silocane (PDMS) membrane can tightly bond the silicon surface to form a sealed channel in the vacuum environment at 150degC in 3 hrs. By applying 10 kPa pressure with the duration of 1000 mus, the chip could simultaneously produce 5 times 5 array on the glass within the area of 3.4mm times 3.4mm. The coefficient of variation (CV) for intensities within 25 individual fluid spots can reach 4.1% and the CV for diameters is as low as 3.8%. The results from both computational fluid dynamics (CFD) simulations and dispensing experiments demonstrated that the fabricated silicon chip can produce uniform microarrays with high stability and good reproducibility in a short time
提出了一种新型微点胶芯片的设计思路和制造方法。灌装过程由毛细力完成,无需额外的能量,大大降低了设计和操作的复杂性。切屑中喷嘴周围的环形间隙有助于液滴在亲水性表面上形成,通道与储液器之间的阶梯连接可以减少流体回流到入口。采用深度反应离子刻蚀(deep reactive ion etching, DRIE)技术,成功制备了25个储层的硅片。聚二甲基硅油(PDMS)膜能在150℃的真空环境下3小时内与硅表面紧密结合形成密封通道。通过施加10 kPa的压力,持续1000 μ s,芯片可以在3.4mm × 3.4mm的玻璃上同时产生5 × 5阵列。25个流体斑内强度的变异系数(CV)可达4.1%,直径的CV低至3.8%。计算流体力学(CFD)模拟和点胶实验结果表明,所制备的硅芯片可以在短时间内制备出稳定性高、重现性好的均匀微阵列
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引用次数: 1
Feasibility Study of Micro Electro-thermal Actuator for Lever Nano Motion 杠杆纳米运动微电热致动器的可行性研究
Xue-jin Shen, Yongyu Zhang, Xiaoyang Chen
The nano manipulation needs miniaturized microtools for minute adjustment or in situ mechanical characterization. This paper demonstrates the feasibility of using bulk silicon electro-thermal expansion micro actuator to drive a lever nano motion platform. The feasibility study includes specimen preparation and dynamic and static characteristic testing. The specimen is made up of a micro electro-thermal actuator and two stage lever with 24.6 lever ratio for transforming the micro displacement of thermal expansion actuator into nano displacement of platform, and the dimension of whole specimen is 1150 mumx 850 mum. The other symmetry two stage lever is used to amplify the nano displacement of platform upon the micro displacement simultaneously for comparing with that one of thermal expansion actuator. The lever fulcrum is flexure hinge. In the testing, the apply voltage ranging from 0 to 5 V. The biggest static input displacement of thermal expansion actuator is more than 2 mum, and the output displacement is about half of the input ones. The non-synchronizing phenomenon has been found in the dynamic process, which is depending on the frequency of applied alternating voltage.
纳米操作需要小型化的微工具进行微小的调整或原位力学表征。本文论证了用体硅电热膨胀微驱动器驱动杠杆纳米运动平台的可行性。可行性研究包括试样制备和动静态特性测试。试件由一个微电热致动器和两级杠杆组成,杠杆比为24.6,用于将热膨胀致动器的微位移转化为平台的纳米位移,试件整体尺寸为1150 μ m × 850 μ m。另一个对称两级杠杆用于将平台的纳米位移同时放大到微位移上,并与热膨胀执行器的纳米位移进行比较。杠杆支点为柔性铰链。在测试中,施加的电压范围从0到5v。热膨胀执行器的最大静态输入位移大于2 μ m,输出位移约为输入位移的一半。在动态过程中发现了不同步现象,这取决于施加交流电压的频率。
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引用次数: 5
Deviations of Electroosmotic Fluidic Profile from Electric Double Layer Theory 电渗透流体剖面与双电层理论的偏差
Yongqian Li, Liding Wang, Zheng Xu
The plug-like fluidic profile is one of most advantages of electroosmotic flow, which influences the reproducibility, sensitivity and separation efficiency of the microfluidic devices. Electroosmotic flow in microchannels with hydraulic diameters of less than 20 microns are investigated experimentally and qualitatively compared with prediction in electric double layer (EDL) theory. Fluidic profiles are obtained using caged-dye based technique with a high degree of resolution near the channel walls. The experimental results indicate the existence of transition zones, which is characterized by a drastic transition in velocity profile as a matching zone between the channel wall and the middle steady flow. The width scale of the transition layer was found to be the same magnitude of hydraulic diameter and much larger than the prediction in EDL theory, which is correlated with the zeta potential and length ratio of Debye length to channel's hydraulic diameter, while the middle profile is influenced by pressure force and the viscidity force. The experiments indicate that the deviations from plug-like velocity profile can be avoided by the reduction of pressure gradient and the channel's dimensional size
微流控器件的重现性、灵敏度和分离效率受到微流控器件的影响,而微流控器件的塞状流控结构是电渗透技术的最大优势之一。对水力直径小于20微米的微通道中的电渗透流动进行了实验和定性研究,并与双电层理论的预测结果进行了比较。流体分布是使用基于笼状染料的技术获得的,在通道壁附近具有高分辨率。实验结果表明,过渡区存在,其特征是作为通道壁面与中间稳定流的匹配区,流速剖面发生剧烈转变。过渡层的宽度尺度与水力直径大小相同,且比EDL理论预测的要大得多,这与zeta势和德拜长度与管道水力直径的长度比有关,而中间剖面受压力力和粘性力的影响。实验结果表明,通过减小压力梯度和减小通道尺寸,可以避免与类塞速度分布的偏差
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引用次数: 1
Liquid Phase Electrochemical Route to Carbon Nanotubes at Room Temperature 室温下碳纳米管的液相电化学途径
H. S. Cheng, M. R. Shen, C. Mak, P. Lim
A novel room temperature synthesis of carbon nanotubes (CNTs) by liquid phase deposition of methanol is firstly reported. Nanotube samples were characterized with field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and Raman spectroscopy. FESEM micrographs revealed that nanotubes with diameter in the range of 20-200 nm were grown at room temperature. HR-TEM images and electron diffraction pattern demonstrated that the as-grown nanotubes were multi-wall carbon nanotubes (MWCNTs). Furthermore, Raman spectra of the nanotubes showed two strong characteristic vibrational modes at 1352 cm-1 and 1585 cm-1, Raman peaks commonly found for carbon nanotubes
本文首次报道了甲醇液相沉积法在室温下合成碳纳米管的新方法。采用场发射扫描电镜(FESEM)、透射电镜(TEM)和拉曼光谱对纳米管样品进行了表征。FESEM显微镜显示,在室温下生长的纳米管直径在20 ~ 200 nm之间。透射电镜和电子衍射图表明,生长的纳米管为多壁碳纳米管(MWCNTs)。此外,纳米管的拉曼光谱在1352 cm-1和1585 cm-1处显示出两个强的特征振动模式,这是碳纳米管常见的拉曼峰
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引用次数: 2
Simulation and Analysis of Dynamic Biomolecule Identification Technique Based on Molecular Motors and GMR Effect 基于分子马达和GMR效应的动态生物分子识别技术仿真与分析
Dan Wu, Changzhe Wu, J. Yue, Ming Wang, T. Song
ATP synthase is the minimal molecular motor and a highly efficient rotary machine. Giant magnetoresistance (GMR) effect is the change in electrical resistance that occurs when materials are exposed to a magnetic field. In this paper, a new dynamic biomolecule identification technique is proposed using GMR sensor combined with ATP molecular motors. Molecular motors, attached with magnetic nano-particles, can be rotated by special magnetic field. If there is specific target molecular in the sample combining with the probe molecular which is labeled on the molecular motor, the load of the molecular motor will be changed. So the movement of the molecular motor is changed, which can be detected by GMR sensor. Without the procedure of pre-treating, labeling the sample, and removing the redundant label, the biomolecule identification system could be manufactured in portable size and conveniently used in many fields. A physical model was established to simulate the identification system and a mathematic model was generated to analyze dynamics of molecular motor's rotating. The experiment results and the simulation results are consistent. It certificates the feasibility of this technique to identify biomolecule.
ATP合酶是最小的分子马达和高效率的旋转机器。巨磁阻(GMR)效应是当材料暴露在磁场中时发生的电阻变化。本文提出了一种利用GMR传感器与ATP分子马达相结合的动态生物分子识别技术。分子马达附着磁性纳米粒子,在特殊的磁场作用下旋转。如果样品中有特定的靶分子与标记在分子马达上的探针分子结合,就会改变分子马达的负载。因此分子马达的运动发生了变化,这种变化可以被GMR传感器检测到。该生物分子识别系统无需预处理、标记、去除冗余标记等步骤,可制作成便携尺寸,可方便地应用于许多领域。建立了识别系统的物理模型,并建立了分子马达旋转动力学分析的数学模型。实验结果与仿真结果一致。验证了该技术用于生物分子识别的可行性。
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引用次数: 0
Double Matched Microgyro Resonant System in Drive and Sense Modes 驱动和感应模式双匹配微陀螺谐振系统
Dunzhu Xia, Bailing Zhou, Shourong Wang
The working principle of Micromechanical Resonator is introduced by using control theory. The Q of the MEMS resonator is very important under different vacuum condition. Theoretically, the sense mode motion is amplified by the mechanical quality factor of the sense mode when the two frequencies are closely matched. To achieve a high stability driving not only at the aspect of resonance frequency but also at its amplitude. An intelligent Double Matched Resonance system based on DSP chip and DDS combined techniques is presented and a design frame for a new type intelligent closed-loop drive generator is proposed. The interface method in digital circuitry part and the weak signal detection technique in analogy circuitry part are analyzed in detail. Combined with closed-loop experiment data and scanning curves, several frequency searching approaches in different vacuum circumstance are presented. After automatic sweeping to their resonance frequency, a number of MEMS z-axis rate gyroscope can work in excellent stability.
运用控制理论介绍了微机械谐振器的工作原理。在不同的真空条件下,MEMS谐振器的Q值是非常重要的。从理论上讲,当两个频率紧密匹配时,感模运动被感模的机械品质因子放大。不仅在谐振频率方面,而且在其振幅方面都实现了高稳定性的驱动。提出了一种基于DSP芯片和DDS技术相结合的智能双匹配共振系统,并提出了一种新型智能闭环驱动发电机的设计框架。详细分析了数字电路部分的接口方法和类比电路部分的微弱信号检测技术。结合闭环实验数据和扫描曲线,给出了不同真空环境下的几种频率搜索方法。许多MEMS z轴速率陀螺仪在自动扫频到谐振频率后,可以在良好的稳定性下工作。
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引用次数: 0
Fabricating Microelectrode with Nano Radius Tip by Electrochemical Micromachining 利用电化学微加工技术制备纳米半径微电极
Zhenlong Wang, B. Zhu
A fabrication technology of microelectrode with nano radius of its tip was presented in electrochemical micromachining (EMM). The mechanism of pulses EMM was expatriated firstly. The shaping principle of microelectrode and micro probe was analyzed. Based on the fundamental experimental behavior of EMM current, a control strategy of current density was proposed with the gap variance. Then an experimental setup was constructed with pulses power supply and a control computer, which could detect the machining process and control the current density. After the experiments of technology analyzed, some microelectrodes were fabricated successfully by tungsten filament. This could provide the simple microelectrode for further electro-machining or micro probe for scanning probe microscopy. Preliminary experimental results show the feasibility of EMM and its potential capability for better machining accuracy and smaller machining size
在电化学微加工中,提出了一种尖端为纳米半径的微电极制备技术。首先阐述了脉冲EMM的机理。分析了微电极和微探针的成形原理。基于EMM电流的基本实验行为,提出了一种随间隙变化的电流密度控制策略。在此基础上,利用脉冲电源和控制计算机建立了加工过程检测和电流密度控制的实验装置。经过工艺分析实验,成功地用钨丝制作了一些微电极。这可以为进一步的电加工提供简单的微电极或为扫描探针显微镜提供微探针。初步实验结果表明,EMM方法是可行的,具有提高加工精度和减小加工尺寸的潜力
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引用次数: 0
期刊
2006 1st IEEE International Conference on Nano/Micro Engineered and Molecular Systems
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