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2011 Fourth International Conference on Modeling, Simulation and Applied Optimization最新文献

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Modeling and optimization of struvite precipitation process for phosphorus recovery from wastewater 鸟粪石沉淀法回收废水中磷的工艺建模与优化
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775497
K. Fattah, D. Mavinic
The recovery of phosphorus from wastewater following struvite precipitation pathway can provide a viable and sustainable source for phosphorus. This pathway is important because current phosphorus ore reserves are expected to be exhausted within the next few decades, or, the recovery from the ores will become more costly. However, the recovery of phosphorus from wastewater is not straightforward due to the complexities arising from the number of variables and chemistry involved with the precipitation of phosphorus as struvite. Modeling the dynamic nature of the crystallization phenomenon appears to be the method of choice to control the process. In this study, a dynamic control model for phosphorus recovery process via struvite crystallization was developed. This model incorporated both chemistry and control software, and was used to increase the efficiency and ease of process operation of a pilot-scale fluidized crystallizer. This process model was the basis of an automatic controller that had the capability to manipulate flows and chemical additions, and thereby control the system at a desired set point. The control model was then used as a prediction tool to determine conditions that influence the supersaturation ratio — the primary control parameter — of the process.
鸟粪石沉淀途径回收废水中的磷可为磷提供一个可行的、可持续的来源。这条途径很重要,因为目前的磷矿储量预计将在未来几十年内耗尽,或者从矿石中回收将变得更加昂贵。然而,从废水中回收磷并不是简单的,因为磷以鸟粪石的形式沉淀的变量和化学成分的数量引起了复杂性。对结晶现象的动态性质进行建模似乎是控制这一过程的首选方法。建立了鸟粪石结晶法回收磷过程的动态控制模型。该模型结合了化学和控制软件,并用于提高中试规模流化结晶器的效率和流程操作的便利性。该过程模型是自动控制器的基础,该控制器具有操纵流量和化学添加剂的能力,从而将系统控制在所需的设定点。然后将控制模型用作预测工具,以确定影响过程的过饱和比(主要控制参数)的条件。
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引用次数: 0
Possibility of genetic restoration for a disease treatment 基因修复治疗疾病的可能性
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775517
T. Tsukahara, Yuji Ooka, S. Alam, H. Suzuki, K. Fujimoto
We are trying to alter the coded message of RNA transcripts by photochemical RNA editing to treat genetic diseases. A mutation of mtDNA T8993C in Leigh syndrome as a model, we subjected site-directed deamination of C to U by reversible photoligation using hairpin-type oligonucleotides with carboxyvinyldeoxy-uridine at the 5'-terminal. We observed significant objective base substituted fragment with ODN2 as a 72mer ODN as a target. Then, we tried to genetic restoration experiments as patient derived samples as targets. ODN2 could restore 10% of the mutated C to U, when in-vitro-synthesized-full-length RNA was used as a target. Moreover, the site-directed deamination was performed even toward total RNA from the patients's cells as a target.
我们正试图通过光化学RNA编辑来改变RNA转录本的编码信息,以治疗遗传疾病。以Leigh综合征mtDNA T8993C突变为模型,我们使用5'端具有羧基乙烯基脱氧尿苷的发针型寡核苷酸,通过可逆光定位将C脱除为U。我们观察到明显的客观碱基取代片段,以ODN2作为72mer的ODN作为目标。然后,我们尝试以患者衍生样本为靶点进行基因修复实验。以体外合成的全长RNA为靶点,ODN2可将10%的突变C恢复为U。此外,位点定向脱氨甚至对来自患者细胞的总RNA作为靶标进行。
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引用次数: 0
Four step implicit block method of Runge-Kutta type for solving first order ordinary differential equations 求解一阶常微分方程的龙格-库塔型四步隐式块法
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775471
H. M. Radzi, Z. Majid, F. Ismail, M. Suleiman
In this paper, a four step implicit block method for solving first order ordinary differential equations (ODEs) is proposed. The method approximates the solutions of initial value problems at four-point mesh simultaneously using variable step size. This four step implicit method is of the multistep type but it is implemented as the Runge-Kutta type. The stability regions of the method are also studied. Numerical results are presented to show the efficiency of the proposed block method.
本文提出了求解一阶常微分方程的四步隐式块法。该方法采用变步长方法同时逼近四点网格初值问题的解。这个四步隐式方法是多步类型,但它是作为龙格-库塔类型实现的。研究了该方法的稳定区域。数值结果表明了该方法的有效性。
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引用次数: 4
A sequential approach for fault detection and identification of vehicles' ultrasonic parking sensors 车辆超声泊车传感器故障检测与识别的顺序方法
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775498
M. Abdel-Hafez, Ahmad Al Nabulsi, A. Jafari, Farouq Al Zaabi, M. Sleiman, Ahmad AbuHatab
This paper presents a sequential fault detection and identification algorithm to be applied for vehicle's ultrasonic parking sensors. The algorithm detects a bias fault in any of the ultrasonic sensors by computing the probability of having that bias fault given a constructed measurement residual that is only a function of the measurement noise and measurement fault. A set of bias hypotheses are assumed and initially given equal alarm probability. It is assumed that only one sensor will acquire a bias at any given time. Once the probability of a hypothesis approaches 1, that hypothesis is declared as the correct hypothesis and the bias associated with the hypothesis is removed from the sensors' reading. This study is essential to ensure accurate operation of vehicle's ultrasonic parking sensors.
提出了一种应用于车辆超声泊车传感器的故障序列检测与识别算法。该算法在给定测量噪声和测量故障的函数的测量残差的情况下,通过计算存在该偏置故障的概率来检测任何超声波传感器中的偏置故障。假设一组偏差假设,并初始给定相等的报警概率。假定在任何给定时间只有一个传感器会获得偏置。一旦一个假设的概率接近1,该假设就被宣布为正确的假设,与该假设相关的偏差就会从传感器的读数中去除。该研究对保证车辆超声泊车传感器的准确工作具有重要意义。
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引用次数: 3
Geosynchronous transfer orbit design: A practical approach 地球同步转移轨道设计:一种实用方法
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775483
E. Hernandez, J. Bolivar, Q. Wang
This paper is proposing a practical approach for a Geosynchronous Transfer Orbit design. To design the intermediate orbits between the injection orbit and the Geosynchronous Orbit were used the Hohmann Transfer Orbit, Keppler 3rd Law and the propellant consumption equations. According to design, these intermediate orbits will be followed by a communication satellite during its orbital maneuver sequence ensuring its final orbital position and minimal fuel consumption. Simulation results and comparison with STK software showed that the approach can simply and effectively be used in the Geosynchronous Transfer Orbit Design.
本文提出了一种实用的地球同步转移轨道设计方法。利用Hohmann转移轨道、Keppler第三定律和推进剂消耗方程设计了注入轨道和地球同步轨道之间的中间轨道。根据设计,在这些中间轨道之后将有一颗通信卫星在其轨道机动序列中确保其最终轨道位置和最小的燃料消耗。仿真结果和与STK软件的比较表明,该方法可以简单有效地用于地球同步转移轨道设计。
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引用次数: 5
Gene expression profiles predict survival of patients with advanced non-small cell lung cancers 基因表达谱预测晚期非小细胞肺癌患者的生存
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775581
R. Harun, J. Hadi, Nur Shukriyah Mhazir, Pang Jyh Chyang, I. Rose, R. Manap, F. Anshar, NorAdina A Tajuddin, Andrea By Li, A Rahman A Jamal
A large variation in prognosis is observed despite the use of clinical prognostic factors in patients with advanced non-small cell lung cancer (NSCLC). It is likely that this variation is due to the different biological properties of the tumour cells. In this work we aimed to identify gene signature that could predict survival in advanced NSCLC. Total RNA was extracted from five 5 μm-thick sections of the FFPE using the High Pure RNA Paraffin Kit (Roche). RNA amplification was performed using WT-Ovation™ FFPE RNA Amplification System V2 (NuGen). The amplified cDNA was then labelled and hybridised onto Illumina HumanRef-8 v3.0 Expression BeadChips. Microarray data analysis was subsequently performed using Genespring GX version 9.0. Out of 75 FFPE samples, only 32 had sufficient RNA quality and quantity for microarray gene expression analysis. Patients were grouped into long and short survival groups based on the time to cancer-related death. After normalization and filtration, 19,002 genes were selected for differential gene expression analysis. A total of 440 genes differed significantly between the long and short survival groups (ANOVA, p < 0.05, with Benjamini and Hochberg False Discovery Rate multiple testing correction). Unsupervised Hierarchial Clustering with Pearson correlation and average linkage identified two broad clusters of patients corresponding to the long and short survival. Thirteen genes were selected based on the TTest, 2-fold expression changes, principal components analysis and univariate Cox regression analysis and risk scores were calculated for each patient. These gene signatures were independent predictors of survival. The model was validated with a published microarray data from 130 patients with NSCLC. Using Gene Set Analysis (GSA), we found certain biological processes including metastasis and chemotherapy resistance were up-regulated in the short survival group while TID pathway and MAPKKK cascade were enriched in the long survival group. As the conclusion, there is several distinct gene expression profiles associated with survival of patients with advanced stage NSCLC. Survival outcomes in advanced NSCLC could be predicted based on a 13-gene signature.
尽管在晚期非小细胞肺癌(NSCLC)患者中使用了临床预后因素,但观察到预后存在很大差异。这种差异很可能是由于肿瘤细胞的不同生物学特性。在这项工作中,我们旨在确定可以预测晚期非小细胞肺癌生存的基因特征。采用高纯度RNA石蜡试剂盒(Roche)从5个5 μm厚的FFPE切片中提取总RNA。采用WT-Ovation™FFPE RNA扩增系统V2 (NuGen)进行RNA扩增。然后将扩增的cDNA标记并杂交到Illumina HumanRef-8 v3.0表达珠芯片上。随后使用genesspring GX version 9.0进行微阵列数据分析。在75个FFPE样本中,只有32个样本具有足够的RNA质量和数量进行微阵列基因表达分析。根据癌症相关死亡的时间,将患者分为长生存组和短生存组。经归一化和过滤后,选择19,002个基因进行差异基因表达分析。长生存组和短生存组共有440个基因差异显著(方差分析,p < 0.05,经Benjamini和Hochberg错误发现率多重检验校正)。无监督分层聚类与Pearson相关和平均连锁确定了两大类患者对应的长生存期和短生存期。根据TTest选择13个基因,进行2倍表达变化、主成分分析和单因素Cox回归分析,计算每位患者的风险评分。这些基因特征是生存的独立预测因子。该模型用来自130例非小细胞肺癌患者的公开微阵列数据进行了验证。通过基因集分析(Gene Set Analysis, GSA),我们发现短生存组的转移和化疗耐药等生物学过程上调,而长生存组的TID通路和MAPKKK级联富集。综上所述,有几种不同的基因表达谱与晚期NSCLC患者的生存相关。晚期非小细胞肺癌的生存结果可以基于13个基因特征来预测。
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引用次数: 2
A simulation optimization approach to un-paced assembly line balancing problem-II with additional reworking issue 带附加返工问题的无节奏装配线平衡问题的仿真优化方法
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775596
M. Noushabadi, U. Bahalke, K. Dolatkhahi, A. Yolmeh
This paper investigates the problem of assembly line balancing problem, in which the products in the production line may undergo to be reworked on the current task. Since the real manufacturing systems deal with the stochastic nature of the items in production lines, this paper considers the simple assembly line balancing problem type 2 (SALBP-II) under the conditions of stochastic processing time of tasks and the element of reworking system. Exposing to the stochastic conditions encouraged us to handle the problem via simulation optimization procedure, which uses the well known genetic algorithm as an optimization tool. Results show the adaptation and effectiveness of GA to considered problem.
本文研究了装配线平衡问题,其中生产线上的产品可能会在当前任务上进行返工。由于实际制造系统处理生产线上产品的随机特性,本文考虑了任务加工时间随机和返工系统要素随机条件下的简单装配线平衡问题2 (SALBP-II)。暴露在随机条件下鼓励我们通过模拟优化程序来处理问题,该程序使用众所周知的遗传算法作为优化工具。结果表明了遗传算法对所考虑问题的适应性和有效性。
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引用次数: 3
Prediction of afflux of bridge constriction with piers using Artificial Neural Network 基于人工神经网络的桥墩收缩流预测
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775538
S. Atabay, Jamal A. Abdalla, G. Seckin, M. Mortula
Bridge constriction in channels usually causes afflux which results in increase in backwater level well above the normal level and may possibly result in overflow on the flood plain surrounding the channel during flooding period. This paper uses Artificial Neural Network to predict the afflux based on the parameters including coefficient of frictions of main channel (nmc) and of floodplain (nfp), bridge width (b) and flow discharge (Q). A Multi-Layer Perceptron (MLP) ANN is used to predict the afflux using these parameters. The training and testing data are the result of experimental investigation. It is observed that the afflux values predicted by the ANN model are very accurate compared to the experimentally measured values with a Normalized Mean Square Error (NMSE) of 0.002 and a Correlation Coefficient of 0.999. The developed ANN model can be used safely to conduct a parametric study to investigate the influence of the parameters nmc, nfp, b and Q on the afflux of a bridge constriction with piers.
河道中的桥梁收缩通常会引起涌水,导致回水水位远远超过正常水平,并可能导致洪水期间河道周围洪泛区的溢流。基于主河道摩擦系数(nmc)、河漫滩摩擦系数(nfp)、桥面宽度(b)、流量(Q)等参数,采用人工神经网络对流量进行预测,并采用多层感知器(MLP)人工神经网络对流量进行预测。训练和测试数据是实验调查的结果。结果表明,人工神经网络模型预测的入流值与实验实测值比较准确,归一化均方误差(NMSE)为0.002,相关系数为0.999。所建立的人工神经网络模型可以安全地用于参数化研究nmc、nfp、b和Q参数对带有桥墩的桥缩流的影响。
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引用次数: 1
Optimization of nonlinearities through control techniques of the quadrotor aerial vehicle 四旋翼飞行器控制技术的非线性优化
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775511
Premeela T. Nathan, H. Almurib
The kinematic and dynamic analysis is applied to the task of controlling and maneuvering the quad-rotor. Here, an evaluation and discussion of the PD (Proportional Derivative) controller is used to navigate the vehicle as it performs basic translational and rotational motions. A comparison is made between the advantages and disadvantages of the controller through the evaluation of the effects of nonlinearities such as atmospheric noise, sensor drift and noise, acceptable range of additional payload and inertial values as well as limitations of maximum rotor speed. Lastly, the most discussed means of quad-rotor optimization are evaluated.
将运动学和动力学分析应用于四旋翼飞行器的控制和机动任务。在这里,评估和讨论PD(比例导数)控制器用于导航车辆,因为它执行基本的平移和旋转运动。通过对大气噪声、传感器漂移和噪声、附加载荷和惯性值可接受范围以及最大旋翼转速限制等非线性影响的评估,比较了该控制器的优缺点。最后,对讨论最多的四旋翼优化方法进行了评价。
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引用次数: 3
Formal methods and automation for system verification 系统验证的形式化方法和自动化
Pub Date : 2011-04-19 DOI: 10.1109/ICMSAO.2011.5775479
H. Krad
Software and hardware systems are growing fast in both functionality and complexity and consequently, the probability of delicate faults existence in these systems is also increasing. Some of these faults may result in disastrous loss in both money and time. One main goal of designing those systems is to construct better and more reliable systems, regardless of the level of their complexity. Formal methods can be used to specify such systems and be automated to verify them. In this paper, we introduce and show how we can use some of those formal methods, Propositional Logic (PL) and First Order Logic (FOL), in specifying and verifying the correctness of related system aspects.
软件和硬件系统在功能和复杂性方面都在快速增长,因此,这些系统中存在细微故障的可能性也在增加。其中一些错误可能会导致灾难性的金钱和时间损失。设计这些系统的一个主要目标是构建更好、更可靠的系统,而不考虑它们的复杂程度。可以使用形式化方法来指定这样的系统,并自动验证它们。在本文中,我们介绍并展示了如何使用这些形式化方法,命题逻辑(PL)和一阶逻辑(FOL)来指定和验证相关系统方面的正确性。
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引用次数: 3
期刊
2011 Fourth International Conference on Modeling, Simulation and Applied Optimization
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