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2007 7th IEEE Conference on Nanotechnology (IEEE NANO)最新文献

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Surface energy induced patterning of polymer nanostructures for cancer diagnosis and therapy 表面能诱导的聚合物纳米结构图像化用于癌症诊断和治疗
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601193
W. Hu, F. Yoon, A. Crouch, Li Tao, H. Hillebrenner, J. S. Guthi, Moon J. Kim, Jinming Gao
We have developed a new simple method to pattern discrete polymer micro and nanostructures. A Si template is patterned by lithography and selective surface treatment to have spatially different surface energies that induce microfluidic self-patterning of a spincoated polymer layer. Biocompatible diblock co-polymer and SU8 are patterned using this method to form monodisperse and shape specific microstructures. After patterning, these particles are lifted off the template surface into aqueous solution. The template is then cleaned and re-used. These freestanding polymer particles with uniform and precise spherical morphology can be used as carriers for drug and imaging agents for biomedical applications.
我们开发了一种新的简单方法来绘制离散聚合物微纳米结构。通过光刻和选择性表面处理对硅模板进行图案化,使其具有空间不同的表面能,从而诱导自旋涂覆聚合物层的微流体自图案化。利用该方法对生物相容性二嵌段共聚物和SU8进行图图化,形成单分散和形状特定的微结构。在制作图案化后,这些颗粒被从模板表面带到水溶液中。然后对模板进行清理和重用。这些独立的聚合物颗粒具有均匀和精确的球形形态,可作为生物医学应用的药物和显像剂的载体。
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引用次数: 1
Young's Modulus of High Aspect Ratio Si3N4 Nano-thickness Membrane 高纵横比氮化硅纳米膜的杨氏模量
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601367
Ping-Hei Chen, Cheng-Hao Yang, Chien-Ying Tsai, Tien-Li Chang, W. Hsu, Tai-Chou Chen
The physical properties of nano-thickness membrane are known to be different from those of bulk material. However, it requires a novel approach to measure the physical properties of nano-thickness membrane due to its nano-scale dimension. Currently, many potential applications for the nanoscale structures are not really practical because their mechanical properties have not been established. In this study, a suspended high aspect ratio silicon nitride nano-thickness membrane is fabricated by using silicon micro-machining. The membrane has a thickness of 30 nm and an area of 4 mm by 7 mm, as shown in Fig.1. Young's modulus of the silicon nitride nano-thickness membrane is determined from the deflection of the suspended membrane, which is resulted from the weight of membrane itself.
纳米膜的物理性质与块状材料不同。然而,由于纳米厚度薄膜的纳米尺度,需要一种新的方法来测量其物理性质。目前,由于纳米结构的力学性能尚未确定,许多潜在的应用并不实际。本研究采用硅微加工技术制备了悬浮式高纵横比氮化硅纳米厚膜。膜的厚度为30nm,面积为4mm × 7mm,如图1所示。氮化硅纳米厚度膜的杨氏模量是由膜自身重量引起的悬浮膜的挠度决定的。
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引用次数: 2
Localized heating of tumor cells utilizing superparamagnetic nanoparticles 利用超顺磁性纳米颗粒局部加热肿瘤细胞
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601345
Hao-Yu Tseng, Chen-Yi Lee, Y. Shih, Xi-Zhang Lin, Gwo-Bin Lee
This paper presents an investigation of hyperthermia cancer therapy utilizing high-frequency magnetic field to induce a localized temperature increase on tumors by using superparamagnetic nanoparticles. In-vitro and in-vivo experiments showed the feasibility of hyperthermia cancer therapy. The relationship between temperature rise and cell survival rate was also investigated. While CT-26 colon cancer cells were heated above 45degC, the survival rate of cancer cells would be greatly reduced. A temperature increase as high as 59.5degC can be successfully generated in rat livers. In-vivo tests also indicated that hyperthermia cancer therapy using this approach could significantly suppress the growth rate of tumors by utilizing concentrated magnetic nanoparticles and temperature-sensitive hydrogel, which was used to secure the nanoparticles in the target tumor tissue. Furthermore, a feedback temperature control system was successfully developed to keep the nanoparticles at a constant temperature to prevent overheating in the tumors such that a safer and more precise cancer therapy is feasible. The developed technique may be promising for the hyperthermia cancer therapy.
本文介绍了一种利用超顺磁性纳米颗粒,利用高频磁场诱导肿瘤局部温度升高的热疗癌症治疗方法。体外和体内实验证明了热疗治疗癌症的可行性。研究了温度升高与细胞存活率的关系。当CT-26结肠癌细胞加热到45℃以上时,癌细胞的存活率会大大降低。老鼠的肝脏可以成功地产生高达59.5摄氏度的温度升高。体内试验还表明,采用这种方法的热疗癌症治疗可以显著抑制肿瘤的生长速度,通过使用浓缩的磁性纳米颗粒和温度敏感的水凝胶,将纳米颗粒固定在目标肿瘤组织中。此外,他们还成功开发了一种反馈温度控制系统,使纳米颗粒保持在恒定的温度,以防止肿瘤过热,从而使更安全、更精确的癌症治疗成为可能。该技术在热疗癌症治疗中具有广阔的应用前景。
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引用次数: 3
Quantum well nanomechanical actuators with atomic vertical resolution 原子垂直分辨率的量子阱纳米力学致动器
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601158
J. D. Makowski, J. Talghader
A novel continuously tunable vertical actuator with sub-nanometer resolution is presented. It consists of a heterostructure cantilever which has collapsed over a 125 nm thick nanogap. Its operating principle relies on the temperature dependence of the adhesion energy between two InGaAs surface quantum well surfaces. Deflections from -17 nm to 5 nm with a precision better than three atomic layers have been measured.
提出了一种新型的亚纳米分辨率连续可调垂直驱动器。它由一个异质结构悬臂组成,该悬臂坍塌在125 nm厚的纳米间隙上。它的工作原理依赖于两个InGaAs表面量子阱表面之间的粘附能的温度依赖性。从-17纳米到5纳米的偏转,其精度优于三个原子层。
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引用次数: 0
Study of nanopattern forming with chemical coatings for silicon-based stamp in nanoimprint process 纳米压印工艺中化学涂层对硅基冲压件纳米图案形成的研究
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601305
Tien-Li Chang, Jung-Chang Wang
The aim of this study is to present a silane molecule self-assembled monolayer (octadecyltrimethoxysilane (CH3(CH2)17Si(OCH3)3): OTS-SAM) as anti-adhesive coatings to improve of silicon-based stamps for the developed nanoimprint lithography (NIL). In this work, the nanostructures of stamps are fabricated by electron-beam lithography (EBL). The diameters of period pillar nanopatterns on the silicon-based stamps are 150 nm and 200 nm, receptively. The influence of silicon-based stamp substrate can be investigated by contact angle measurement after modifying the chemical coating treatment for imprinted thin polymethyl methacrylate (PMMA) films. To control the forming of fabricated nanopatterns, the simulation can be done to obtain the effects of patterning distortion during this NIL process. In addition, the study employs atomic force microscopy (AFM) to obtain a simultaneous observation for the morphologies of silicon-based and imprinted PMMA polymer nanostructures interface. The results indicate an over 95% improvement for silicon-based nanopatterns with the anti-adhesive properties in NIL process.
本研究的目的是提出一种硅烷分子自组装单层(十八烷基三甲氧基硅烷(CH3(CH2)17Si(OCH3)3): OTS-SAM)作为抗粘涂层,以改善用于纳米压印(NIL)的硅基邮票。本文采用电子束光刻(EBL)技术制备了邮票的纳米结构。硅基邮票上的周期柱纳米图案直径分别为150 nm和200 nm。通过对印迹型聚甲基丙烯酸甲酯(PMMA)薄膜进行化学涂覆处理后的接触角测量,研究了硅基冲压衬底对印迹性能的影响。为了控制所制备的纳米图案的形成,可以进行模拟,以获得该过程中图案变形的影响。此外,本研究利用原子力显微镜(AFM)对硅基和印迹PMMA聚合物纳米结构界面的形貌进行了同步观察。结果表明,在NIL工艺下,硅基纳米图案的抗粘接性能提高了95%以上。
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引用次数: 0
Investigation of effects attributed to spherical carbon nanomaterials in proteomic matrix-assisted laser desorption ionization-time of flight mass spectrometer 球形碳纳米材料在蛋白质组学基质辅助激光解吸电离飞行时间质谱仪中的影响研究
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601355
H. Wen, L. Tsai, Chien-Wei Liu, Y. Tyan, S. Shy, B. Dai, P. Liao
The study presents the mass spectrometric application of carbon nanomaterials in proteomic research. We utilized two spherical carbon nanomaterials, C60 buckyball and iron-cored carbonball (Fe-C), in peptide sequence identification of a serum protein using matrix-assisted laser desorption ionization-time of flight mass spectrometer (MALDI-TOF-MS). The biological samples used in the experiments were enzymatically trypsinized bovine serum albumins (BSA) peptides instead of synthesized small peptide fragments. Experimental results were compared and noticeable improvements in mass spectrometric spectrum were obtained and quantified. In addition, we also utilized EDS and TEM to determine the chemical composition and morphology of nanostructure of iron-cored carbonball.
介绍了碳纳米材料质谱技术在蛋白质组学研究中的应用。利用两种球形碳纳米材料C60巴基球和铁芯碳球(Fe-C),利用基质辅助激光解吸电离飞行时间质谱仪(MALDI-TOF-MS)对血清蛋白进行肽序列鉴定。实验中使用的生物样品是酶促胰蛋白酶化的牛血清白蛋白(BSA)肽,而不是合成的小肽片段。对实验结果进行了比较,得到了质谱谱的显著改进并进行了量化。此外,我们还利用EDS和TEM测定了铁芯碳球的化学成分和纳米结构的形貌。
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引用次数: 1
Schrödinger Equation Monte Carlo-3D for simulation of nanoscale MOSFETs Schrödinger模拟纳米级mosfet的Monte Carlo-3D方程
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601380
Keng-Ming Liu, Wanqiang Chen, L. Register, S. Banerjee
A computational efficient quantum transport simulator, Schrodinger equation Monte Carlo in three dimensions (SEMC-3D), for simulating carrier quantum transport subject to scattering in 3D nanoscale MOSFETs is presented. SEMC-3D self-consistently solves (1) for the 2D-confined eigenstates across the channel as a function of position along the channel, (2) the quasi-1D quantum transport equations for injected carriers propagating through the simulation region within the each subband subject to a rigorous treatment of various intra- and inter-subband and valley scattering processes, and (3) the 3D Poisson equation. The technique, an extension of prior 1D and 2D versions of SEMC but subject to some significantly different computational considerations, is briefly described. SEMC-3D simulations of a Si omega-gate nano-scale nMOSFET are provided to illustrate the modeling capabilities and computational efficiency of SEMC-3D.
提出了一种计算效率高的量子输运模拟器——三维薛定谔方程蒙特卡罗(SEMC-3D),用于模拟三维纳米mosfet中受散射影响的载流子量子输运。SEMC-3D自一致地求解了(1)沿通道沿位置的二维受限本征态函数,(2)经过严格处理各种子带内、子带间和谷散射过程,在每个子带内通过模拟区域传播的注入载流子的准一维量子输运方程,以及(3)三维泊松方程。该技术是先前的1D和2D版本SEMC的扩展,但受到一些显着不同的计算考虑,简要描述。给出了一个Si ω栅极纳米级nMOSFET的SEMC-3D仿真,以说明SEMC-3D的建模能力和计算效率。
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引用次数: 0
Applications of magnetic nanoparticles in engineering and biomedical science 磁性纳米颗粒在工程和生物医学中的应用
Pub Date : 2007-12-01 DOI: 10.1109/NANO.2007.4601275
Tien-Li Chang, Ya-Wei Lee
This study mainly employs magnetic nanoparticles (MNPs) for an amazing variety of engineering and biomedical applications. Herein MNPs are fabricated from fine ferromagnetic particles of iron ferrite by chemical co-precipitation technique, and their average size is about 27 nm via HR-TEM micrograph and XRD analysis to investigate. In this study, MNPs have been demonstrated their excellent properties of heat transfer, electric conductivity, magnetism within the applications for multi-loop pulsating heat pipe (MLPHP), switch-based nanodevice, microfluidic on-chip system and nanogap-based DNA sensor. Based on the effect of magnetic field for MNPs, MLPHP can enhance thermal performance itself at different heating power. In addition, the switch-based nanodevice with MNPs can efficiently add and remove an electrical function of electron charging with current shift. Furthermore, the microfluidic chip utilizing MNPs is demonstrated that can be suited for drug delivThis study mainly employs magnetic nanoparticles (MNPs) for an amazing variety of engineering and biomedical applications. Herein MNPs are fabricated from fine ferromagnetic particles of iron ferrite by chemical co-precipitation technique, and their average size is about 27 nm via HR-TEM micrograph and XRD analysis to investigate. In this study, MNPs have been demonstrated their excellent properties of heat transfer, electric conductivity, magnetism within the applications for multi-loop pulsating heat pipe (MLPHP), switch-based nanodevice, microfluidic on-chip system and nanogap-based DNA sensor. Based on the effect of magnetic field for MNPs, MLPHP can enhance thermal performance itself at different heating power. In addition, the switch-based nanodevice with MNPs can efficiently add and remove an electrical function of electron charging with current shift. Furthermore, the microfluidic chip utilizing MNPs is demonstrated that can be suited for drug delivery. Finally, we use MNPs to develop an electrical approach to detect femtomolar DNA that can amplify the low target DNA concentration for a clinical gene diagnostic system.ery. Finally, we use MNPs to develop an electrical approach to detect femtomolar DNA that can amplify the low target DNA concentration for a clinical gene diagnostic system.
本研究主要采用磁性纳米颗粒(MNPs)用于各种工程和生物医学应用。本文采用化学共沉淀法将铁氧体铁磁微粒制备成MNPs,通过HR-TEM显微照片和XRD分析研究其平均尺寸约为27 nm。在这项研究中,MNPs在多回路脉动热管(MLPHP)、基于开关的纳米器件、微流控片上系统和基于纳米间隙的DNA传感器等方面的应用证明了其优异的传热、导电性和磁性。基于磁场对MNPs的影响,MLPHP可以在不同的加热功率下增强自身的热性能。此外,基于开关的纳米器件可以有效地增加和去除电子随电流移动充电的电学功能。此外,利用磁性纳米颗粒(MNPs)的微流控芯片被证明可以适用于药物输送。这项研究主要利用磁性纳米颗粒(MNPs)在各种工程和生物医学应用中得到惊人的应用。本文采用化学共沉淀法将铁氧体铁磁微粒制备成MNPs,通过HR-TEM显微照片和XRD分析研究其平均尺寸约为27 nm。在这项研究中,MNPs在多回路脉动热管(MLPHP)、基于开关的纳米器件、微流控片上系统和基于纳米间隙的DNA传感器等方面的应用证明了其优异的传热、导电性和磁性。基于磁场对MNPs的影响,MLPHP可以在不同的加热功率下增强自身的热性能。此外,基于开关的纳米器件可以有效地增加和去除电子随电流移动充电的电学功能。此外,利用MNPs的微流控芯片可以适用于药物输送。最后,我们使用MNPs开发了一种检测飞摩尔DNA的电方法,可以为临床基因诊断系统放大低目标DNA浓度。最后,我们使用MNPs开发了一种检测飞摩尔DNA的电方法,可以为临床基因诊断系统放大低目标DNA浓度。
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引用次数: 8
Improved spectral response of an InAs QD RC-SACM-APD with Ta2O5/SiO2 DBRs Ta2O5/SiO2 dbr改善了InAs QD RC-SACM-APD的光谱响应
Pub Date : 2007-08-01 DOI: 10.1109/NANO.2007.4601281
Dong Ho Kim, H. Song, C. Roh, C. Hahn, Shi-Jong Leem, N. Tsurumachi, Tae Geun Kim
We report the improvement in the spectral response of an InAs QD resonant-cavity separate absorption, charge, and multiplication avalanche photodetector (RC-SACM-APD) by increasing the quantum efficiency (QE) using dielectric Ta2O5/SiO2 top distributed Bragg reflectors (DBRs). The reflectivities of the top and bottom DBRs were numerically designed to be 70 % and 99.1 %, respectively, in order to maximize the QE. The spectral response characteristics of the InAs QD RC-SACM-APD with enhanced top DBRs was remarkably improved at 1098 nm, which is close to the target wavelength of 1100 nm, and its full width at half-maximum (FWHM) was 19 nm. The photoluminescence (PL) spectra revealed an intense and narrow single-mode peak at 1101 nm. The FWHM of the PL peak was as narrow as 8 nm and the difference in wavelength between the spectrum and the PL peak was as small as 3 nm.
本文报道了使用介质Ta2O5/SiO2顶部分布布拉格反射器(DBRs)提高量子效率(QE),从而改善了InAs QD谐振腔分离吸收、电荷和倍增雪崩探测器(RC-SACM-APD)的光谱响应。为了使QE最大化,顶部和底部dbr的反射率分别被数值设计为70%和99.1%。顶部dbr增强后的InAs QD RC-SACM-APD在1098 nm处的光谱响应特性得到了显著改善,接近1100 nm的目标波长,半峰全宽(FWHM)为19 nm。光致发光(PL)光谱在1101 nm处显示一个强而窄的单模峰。光谱线峰的频宽窄至8 nm,光谱与光谱线峰的波长差小至3 nm。
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引用次数: 1
The mechanisms of PAN electrospinning nanofibers based on the effect of surface charges 基于表面电荷效应的聚丙烯腈静电纺丝纳米纤维机理研究
Pub Date : 2007-08-01 DOI: 10.1109/NANO.2007.4601238
Xiao-hong Qin, Shanyuan Wang
In electrospinning, the addition of salts results in a higher charge density on the surface of jet. The theoretical analysis shows that the relationship between radius r of jet and the axial distance z from nozzle follows an allometric law in the form r ~ z-0.5 in case of full surface charge, and the scaling exponent becomes larger when the jet has part surface charge. Theoretical analysis also showed that the electricity potential with high content of LiCl descends more sharply than low content LiCl during the charged fibers moving. LiCl was chosen to confirm the theory. The experimental data agreed very well with our theoretical analysis by a series of experiments. Moreover, the structures of nanofibers with LiCl were investigated.
在静电纺丝中,盐的加入使喷流表面的电荷密度增大。理论分析表明,射流半径r与距喷管轴向距离z之间的关系在表面满荷时呈异速生长规律,表现为r ~ z-0.5,当射流有部分表面荷时,标度指数变大。理论分析还表明,在带电光纤移动过程中,高含量LiCl的电势比低含量LiCl的电势下降得更快。LiCl被选来证实这一理论。通过一系列的实验,得到的实验数据与我们的理论分析吻合得很好。此外,还研究了含LiCl纳米纤维的结构。
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引用次数: 0
期刊
2007 7th IEEE Conference on Nanotechnology (IEEE NANO)
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