首页 > 最新文献

化学与化工:英文版最新文献

英文 中文
Analysis of γ-Hydroxybutyrate in Human Urine by LC-MS/MS Method and Its Forensic Application 人尿中γ-羟基丁酸盐的LC-MS/MS分析及其法医学应用
Pub Date : 2017-03-28 DOI: 10.17265/1934-7375/2017.03.001
Lu Yujing, Wang Ruihua, Dong Ying
GHB (γ-hydroxybutyrate) is becoming popular recreational drugs. As a result of its strong sedative and amnesiac effects, GHB has been implicated in a number of DFSA cases. The natural presence of GHB in the human body and its rapid elimination after ingestion make it difficult to detect and to evaluate its roles in suspected GHB-facilitated assaults. The paper describes an analytical method for the determination of GHB in urine using LC-MS/MS. Samples were acidified by ammonium chloride solution and extracted with ethyl acetate, and then the extracts were analysed by LC-MS/MS. The limit of detection was 0.05 μg/mL (S/N = 3). The intraand inter-day precision was within 10.0% at three concentrations. The methods were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test GHB in real cases.
GHB(γ-羟基丁酸)正成为流行的娱乐药物。由于其强大的镇静和健忘症作用,GHB已与许多DFSA病例有关。GHB在人体内的自然存在及其摄入后的快速消除使其难以检测和评估其在疑似GHB引发的袭击中的作用。本文介绍了一种用LC-MS/MS测定尿液中GHB的分析方法。样品用氯化铵溶液酸化,用乙酸乙酯提取,然后用LC-MS/MS分析提取物。检出限为0.05μg/mL(S/N=3)。三种浓度的日内和日间精密度均在10.0%以内。该方法灵敏、准确、快速,适用于实际案件中GHB的法医毒理学检测。
{"title":"Analysis of γ-Hydroxybutyrate in Human Urine by LC-MS/MS Method and Its Forensic Application","authors":"Lu Yujing, Wang Ruihua, Dong Ying","doi":"10.17265/1934-7375/2017.03.001","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.03.001","url":null,"abstract":"GHB (γ-hydroxybutyrate) is becoming popular recreational drugs. As a result of its strong sedative and amnesiac effects, GHB has been implicated in a number of DFSA cases. The natural presence of GHB in the human body and its rapid elimination after ingestion make it difficult to detect and to evaluate its roles in suspected GHB-facilitated assaults. The paper describes an analytical method for the determination of GHB in urine using LC-MS/MS. Samples were acidified by ammonium chloride solution and extracted with ethyl acetate, and then the extracts were analysed by LC-MS/MS. The limit of detection was 0.05 μg/mL (S/N = 3). The intraand inter-day precision was within 10.0% at three concentrations. The methods were found to be sensitive, accurate, rapid and suitable for the forensic toxicology to test GHB in real cases.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44348789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reflection—The Story of Water 反思——水的故事
Pub Date : 2017-03-28 DOI: 10.17265/1934-7375/2017.03.005
Marijan Magdić, Vlatka Husetović, Mirna Coljak
{"title":"Reflection—The Story of Water","authors":"Marijan Magdić, Vlatka Husetović, Mirna Coljak","doi":"10.17265/1934-7375/2017.03.005","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.03.005","url":null,"abstract":"","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42089889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Various Extensions of Original Born-Kramers-Slater Model for Reactions Kinetics Based on Brownian Motion and Fokker-Plank Equation Including 1D, 2D, 3D, and Multi-dimensional Approaches 基于布朗运动和Fokker-Plank方程的原Born-Kramers-Slater反应动力学模型的各种扩展,包括1D, 2D, 3D和多维方法
Pub Date : 2017-03-28 DOI: 10.17265/1934-7375/2017.03.002
Michael Fundator
Different extensions, such as Transition State theory of Eyring-Polanyi-Evans model of the original Born-Kramers-Slater Model for the Velocity of Chemical Reactions are discussed based on Smoluchowski and Fokker-Plank equations with various properties of Brownian motion and including 1-, 2-, 3-, and multidimensional models with applications in Neuroscience.
基于具有各种布朗运动性质的Smoluchowski方程和Fokker-Plank方程,讨论了不同的扩展,如化学反应速度的原始Born-Kramers-Slater模型的eyling - polanyi - evans模型的过渡态理论,包括在神经科学中的应用的1-、2-、3-和多维模型。
{"title":"Various Extensions of Original Born-Kramers-Slater Model for Reactions Kinetics Based on Brownian Motion and Fokker-Plank Equation Including 1D, 2D, 3D, and Multi-dimensional Approaches","authors":"Michael Fundator","doi":"10.17265/1934-7375/2017.03.002","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.03.002","url":null,"abstract":"Different extensions, such as Transition State theory of Eyring-Polanyi-Evans model of the original Born-Kramers-Slater Model for the Velocity of Chemical Reactions are discussed based on Smoluchowski and Fokker-Plank equations with various properties of Brownian motion and including 1-, 2-, 3-, and multidimensional models with applications in Neuroscience.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43701879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Sensory evaluation of winter cereal silage. 冬季谷物青贮的感官评价。
Pub Date : 2017-03-28 DOI: 10.17265/1934-7375/2017.03.004
Carlos Eugênio Fortes Teixeira, R. S. Fontaneli
Silage is aimed at conservation of green fodder, with minimal losses and that this kind of food, does not occur formation of toxic compounds for animals. Practical aspects become important when control “in loco”, reflects management practiced in the property. There are different sensory evaluation techniques. The objective of this work was to study the applicability of the German system, now used in sensory evaluation of winter cereals (wheat silage and haylage oats). For quantitative analysis of silage (pH) that was used potentiometer. In determining the qualitative analysis was used German method adapted. Relating them to sensory characteristics such as smell, texture and color of the fodder saved by assigning a score to each sensory: a “key” predetermined quality identification. For multiple comparisons for film types tested in oat silages BRS Centauro, the results show that the qualitative sensory attributes evaluated by rating corresponded to the quantitative attributes (pH) evaluated, with no difference. For multiple comparisons in the silages, for all test loads in both wheat genotypes results showed no difference between the qualitative evaluation (sensory) and quantitative.
青贮的目的是保存绿色饲料,使其损失最小,而且这种食物不会对动物产生有毒化合物。当“就地”控制时,实践方面变得重要,反映了物业管理的实践。有不同的感官评估技术。这项工作的目的是研究德国系统的适用性,现在用于冬季谷物(小麦青贮和干草燕麦)的感官评价。采用电位器定量分析青贮饲料的pH值。在定性分析中采用了德国方法。通过给每一种感官打分,将它们与嗅觉、质地和颜色等感官特征联系起来:一种预先确定的质量识别“关键”。对不同类型的燕麦青贮BRS Centauro进行了多次比较,结果表明,分级评价的定性感官属性与评价的定量属性(pH)相对应,没有差异。在青贮的多重比较中,对于两种小麦基因型的所有试验负荷,定性评价(感官)和定量评价结果没有差异。
{"title":"Sensory evaluation of winter cereal silage.","authors":"Carlos Eugênio Fortes Teixeira, R. S. Fontaneli","doi":"10.17265/1934-7375/2017.03.004","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.03.004","url":null,"abstract":"Silage is aimed at conservation of green fodder, with minimal losses and that this kind of food, does not occur formation of toxic compounds for animals. Practical aspects become important when control “in loco”, reflects management practiced in the property. There are different sensory evaluation techniques. The objective of this work was to study the applicability of the German system, now used in sensory evaluation of winter cereals (wheat silage and haylage oats). For quantitative analysis of silage (pH) that was used potentiometer. In determining the qualitative analysis was used German method adapted. Relating them to sensory characteristics such as smell, texture and color of the fodder saved by assigning a score to each sensory: a “key” predetermined quality identification. For multiple comparisons for film types tested in oat silages BRS Centauro, the results show that the qualitative sensory attributes evaluated by rating corresponded to the quantitative attributes (pH) evaluated, with no difference. For multiple comparisons in the silages, for all test loads in both wheat genotypes results showed no difference between the qualitative evaluation (sensory) and quantitative.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43194811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Spin-Boson and Spin-Fermion Topological Model of Consciousness 意识的自旋玻色子和自旋费米拓扑模型
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.003
A. Yerkin, Yemelyanova Valentina, Nakisbekov Narymzhan, Alzhanuly Bakhytzhan, S. Ruben
The authors propose a new approach to the theory of spin-boson and spin-fermion topological model of consciousness. The authors will offer a common mechanism of spin-boson and spin-fermion topological model of consciousness.
作者对意识的自旋玻色子理论和自旋费米子拓扑模型提出了一种新的方法。作者将提供一个常见的自旋玻色子机制和意识的自旋费米子拓扑模型。
{"title":"Spin-Boson and Spin-Fermion Topological Model of Consciousness","authors":"A. Yerkin, Yemelyanova Valentina, Nakisbekov Narymzhan, Alzhanuly Bakhytzhan, S. Ruben","doi":"10.17265/1934-7375/2017.02.003","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.003","url":null,"abstract":"The authors propose a new approach to the theory of spin-boson and spin-fermion topological model of consciousness. The authors will offer a common mechanism of spin-boson and spin-fermion topological model of consciousness.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43397926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid Microwave-accelerated Multi-step Synthesis of 2,6-di(naphthalene Thioureido Carbamino)Pyridine 微波加速多步快速合成2,6-二(萘硫脲氨基)吡啶
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.007
Hai-Rui Zhang, Guo-Fu Zhang
A rapid and simple procedure for synthesis of 2,6-di(naphthalene thioureido carbamino)pyridine fluorescine anion acceptor by the reaction between pyridine-2,6-dicarbohydrazide obtained from 2,6-dimethylpyridine after three-step reaction and 1-naphthyl isothiocyanate is described, and all reactions could be carried out under microwave heating condition.
介绍了由2,6-二甲基吡啶经三步反应得到的吡啶-2,6-二碳酰肼与1-萘异硫氰酸酯反应,快速简便地合成2,6-二(萘硫脲基氨基)吡啶荧光阴离子受体的方法,所有反应都可以在微波加热条件下进行。
{"title":"Rapid Microwave-accelerated Multi-step Synthesis of 2,6-di(naphthalene Thioureido Carbamino)Pyridine","authors":"Hai-Rui Zhang, Guo-Fu Zhang","doi":"10.17265/1934-7375/2017.02.007","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.007","url":null,"abstract":"A rapid and simple procedure for synthesis of 2,6-di(naphthalene thioureido carbamino)pyridine fluorescine anion acceptor by the reaction between pyridine-2,6-dicarbohydrazide obtained from 2,6-dimethylpyridine after three-step reaction and 1-naphthyl isothiocyanate is described, and all reactions could be carried out under microwave heating condition.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41936621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
About New Inorganic Polymers-Double Condensed Phosphates of Silver and Trivalent Metals 关于新型无机聚合物银和三价金属的双凝聚磷酸盐
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.004
M. Avaliani, E. Shapakidze, N. Barnovi, M. Gvelesiani, D. Dzanashvili
A distinctive feature of phosphates is their special and significant ability to form inorganic polymeric compounds—condensed phosphates, which are destined to play a considerable role in our “high-tech” society in the future. Numerous olygophosphates, polyphosphates, double condensed phosphates and cyclophosphates with diverse formula, such as double tetra-, octaand dodecaphosphates were obtained and described by us last years. The offered data are the outcomes of our scientific researches: of synthesis, analysis, and estimation of results in correlation with new achievements in inorganic polymer’s chemistry. Many double condensed compounds, containing monovalent metals are obtained by us during systematic investigation of polycomponent systems, containing monoand trivalent metals at temperature range 100-600 °C. Synthesised condensed phosphates, in fact—inorganic polymers were examined in detail by chemical and thermogravimetric analysis, most compounds were examined by paper chromatography and the structures are determined by X-ray structural techniques/diffraction analysis. During our fundamental researches numerous new (about 70) unknown until now condensed phosphates have been obtained. Dependency of composition VS temperature and molar ratio, reliance of structure from duration of synthesis and radius of the ions are revealed.
磷酸盐的一个显著特点是它们形成无机聚合物化合物——缩合磷酸盐的特殊而显著的能力,这些化合物注定会在我们未来的“高科技”社会中发挥重要作用。近年来,我们获得并描述了许多具有不同结构式的多聚磷酸盐、多聚磷酸盐,双缩合磷酸盐和环磷酸盐,如双四聚磷酸盐、双八聚磷酸盐和双十二聚磷酸盐。所提供的数据是我们科学研究的成果:合成、分析和与无机聚合物化学新成果相关的结果估计。我们在对温度范围为100-600°C的含有单价金属和三价金属的多组分体系进行系统研究时,获得了许多含有单价金属的双缩合化合物。合成的缩合磷酸盐,实际上是无机聚合物,通过化学和热重分析进行了详细检查,大多数化合物通过纸层析进行了检查,结构通过X射线结构技术/衍射分析确定。在我们的基础研究中,已经获得了许多迄今为止未知的新的(约70种)缩合磷酸盐。揭示了组成对温度和摩尔比的依赖性,结构对合成时间和离子半径的依赖性。
{"title":"About New Inorganic Polymers-Double Condensed Phosphates of Silver and Trivalent Metals","authors":"M. Avaliani, E. Shapakidze, N. Barnovi, M. Gvelesiani, D. Dzanashvili","doi":"10.17265/1934-7375/2017.02.004","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.004","url":null,"abstract":"A distinctive feature of phosphates is their special and significant ability to form inorganic polymeric compounds—condensed phosphates, which are destined to play a considerable role in our “high-tech” society in the future. Numerous olygophosphates, polyphosphates, double condensed phosphates and cyclophosphates with diverse formula, such as double tetra-, octaand dodecaphosphates were obtained and described by us last years. The offered data are the outcomes of our scientific researches: of synthesis, analysis, and estimation of results in correlation with new achievements in inorganic polymer’s chemistry. Many double condensed compounds, containing monovalent metals are obtained by us during systematic investigation of polycomponent systems, containing monoand trivalent metals at temperature range 100-600 °C. Synthesised condensed phosphates, in fact—inorganic polymers were examined in detail by chemical and thermogravimetric analysis, most compounds were examined by paper chromatography and the structures are determined by X-ray structural techniques/diffraction analysis. During our fundamental researches numerous new (about 70) unknown until now condensed phosphates have been obtained. Dependency of composition VS temperature and molar ratio, reliance of structure from duration of synthesis and radius of the ions are revealed.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43426994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Formulation of Domperidone Microspheres Using a Combination of Locally Extracted Chitosan and Hpmc as Polymers 局部提取壳聚糖与Hpmc复合聚合物制备多潘立酮微球
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.005
S. Majekodunmi, Cynthia Chibuzor Uzoaganobi
Commercially available domperidone -a D2 receptor antagonistis an immediate release formulation which has never been formulated into microspheres for sustained release. The present work aims towards studying the effect of combination of a natural chitosan from an oyster shell of Mystilis edulis and HPMC (hydroxy propyl methyl cellulose) (spectracel 15 E) as polymer and tripolyphosphate as cross linking agent using wet gelation technique. The various polymer combination ratios for different batches were compared with a low molecular weight standard chitosan. The extracted chitosan – HPMC polymer combination ratios were chosen at ten levels: as batches B1, B2, B3, B4, B5, B6, B7, B8, B9, B10 for 1:1, 1:2, 2:1, 1:0, 0:1, 3:1, 1:3, 5:1, and 1:5 and 1:1 having 450:450, 300:600, 600:300, 900:0, 0:900, 675:225, 225:675, 750:150, 150:750, 450:450 mg respectively, while the quantity of domperidone and tripolyphosphate remained constant. B11 and B12 were formulated with standard chitosan and HPMC. The percentage yield of the formulated microspheres was determined and then evaluated for flowability, drug entrapment efficiency, drug release and mechanism of drug release by Fickian diffusion. The best batches of the domperidone loaded microspheres produced from the combination polymer were compared with the standard chitosan. The highest yields of microspheres were given by batches B12, B11, B10, and B4 with values of 50.1 ± 0.1%, 49.6 ± 0.1%, 46.6 ± 0.1%, and 46.1 ± 0.0% respectively while the lowest yield were 23.3 ± 0.2% and 23.6 ± 0.2%. B5 and B6 and B9 did not yield any microsphere. The bulk density, tapped density, compressibility and Hausner’s ratio of the microspheres showed good flowability and high percent compressibility. The drug entrapment efficiency showed that the entrapment ranged from 54.2 to 97.2, where the least entrapment was B4 (54.2 ± 0.1) and the highest B12 (97.2 ± 0.2). The polymer surface of the microspheres as observed by SEM (scanning electron microscopy) was heterogeneous and porous which offers enhanced bioadhesivity. The dissolution study was used to determine the percentage drug release which ranged from 12.1% to 68.9% after 5 hours. Batches 1, 2, 3, 4, 7, and 11 follow zero order kinetics via Fickian diffusion. The results indicate that microspheres of domperidone could be successfully formulated with a natural chitosan either alone or in combination with HPMC for sustained delivery of domperidone. Furthermore, the concentration of the natural polymer and HPMC employed in the formulation need to be carefully selected to enable the production of microspheres with the desired sustained release properties.
市售多潘立酮-一种D2受体拮抗剂,是一种从未配制成缓释微球的立即释放制剂。本工作旨在利用湿凝胶化技术研究从Mystilis edulis牡蛎壳中提取的天然壳聚糖与HPMC(羟丙基甲基纤维素)(spectracel 15E)作为聚合物和三聚磷酸盐作为交联剂的组合效果。将不同批次的各种聚合物组合比例与低分子量标准壳聚糖进行比较。提取的壳聚糖-HPMC聚合物组合比例在10个水平上选择:批次B1、B2、B3、B4、B5、B6、B7、B8、B9、B10分别为1:1、1:2、2:1、1:0、0:1、3:1、1:3、5:1和1:5和1:1,分别为450:450、300:600、600:30、900:0、0:900、675:225、225:675、750:150、150:750、450:450 mg,而多潘立酮和三聚磷酸的量保持不变。B11和B12是用标准壳聚糖和HPMC配制的。测定了配方微球的产率,然后通过Fickian扩散评估了其流动性、药物包封率、药物释放和药物释放机制。将该复合聚合物制备的多潘立酮微球的最佳批次与标准壳聚糖进行了比较。微球产量最高的是批次B12、B11、B10和B4,分别为50.1±0.1%、49.6±0.1%、46.6±0.1%和46.1±0.0%,而产量最低的是23.3±0.2%和23.6±0.2%。B5、B6和B9没有产生任何微球。微球的体积密度、振实密度、压缩性和豪斯纳比均表现出良好的流动性和较高的压缩率。药物包封率为54.2~97.2,其中包封率最低的是B4(54.2±0.1),最高的是B12(97.2±0.2)。SEM(扫描电子显微镜)观察到微球的聚合物表面是不均匀的和多孔的,具有增强的生物粘附性。溶出度研究用于确定5小时后药物释放的百分比,其范围为12.1%-68.9%。批次1、2、3、4、7和11通过菲克扩散遵循零级动力学。结果表明,多潘立酮微球可以与天然壳聚糖单独或与HPMC联合成功配制,用于多潘立顿的持续递送。此外,需要仔细选择配方中使用的天然聚合物和HPMC的浓度,以生产具有所需缓释性能的微球。
{"title":"Formulation of Domperidone Microspheres Using a Combination of Locally Extracted Chitosan and Hpmc as Polymers","authors":"S. Majekodunmi, Cynthia Chibuzor Uzoaganobi","doi":"10.17265/1934-7375/2017.02.005","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.005","url":null,"abstract":"Commercially available domperidone -a D2 receptor antagonistis an immediate release formulation which has never been formulated into microspheres for sustained release. The present work aims towards studying the effect of combination of a natural chitosan from an oyster shell of Mystilis edulis and HPMC (hydroxy propyl methyl cellulose) (spectracel 15 E) as polymer and tripolyphosphate as cross linking agent using wet gelation technique. The various polymer combination ratios for different batches were compared with a low molecular weight standard chitosan. The extracted chitosan – HPMC polymer combination ratios were chosen at ten levels: as batches B1, B2, B3, B4, B5, B6, B7, B8, B9, B10 for 1:1, 1:2, 2:1, 1:0, 0:1, 3:1, 1:3, 5:1, and 1:5 and 1:1 having 450:450, 300:600, 600:300, 900:0, 0:900, 675:225, 225:675, 750:150, 150:750, 450:450 mg respectively, while the quantity of domperidone and tripolyphosphate remained constant. B11 and B12 were formulated with standard chitosan and HPMC. The percentage yield of the formulated microspheres was determined and then evaluated for flowability, drug entrapment efficiency, drug release and mechanism of drug release by Fickian diffusion. The best batches of the domperidone loaded microspheres produced from the combination polymer were compared with the standard chitosan. The highest yields of microspheres were given by batches B12, B11, B10, and B4 with values of 50.1 ± 0.1%, 49.6 ± 0.1%, 46.6 ± 0.1%, and 46.1 ± 0.0% respectively while the lowest yield were 23.3 ± 0.2% and 23.6 ± 0.2%. B5 and B6 and B9 did not yield any microsphere. The bulk density, tapped density, compressibility and Hausner’s ratio of the microspheres showed good flowability and high percent compressibility. The drug entrapment efficiency showed that the entrapment ranged from 54.2 to 97.2, where the least entrapment was B4 (54.2 ± 0.1) and the highest B12 (97.2 ± 0.2). The polymer surface of the microspheres as observed by SEM (scanning electron microscopy) was heterogeneous and porous which offers enhanced bioadhesivity. The dissolution study was used to determine the percentage drug release which ranged from 12.1% to 68.9% after 5 hours. Batches 1, 2, 3, 4, 7, and 11 follow zero order kinetics via Fickian diffusion. The results indicate that microspheres of domperidone could be successfully formulated with a natural chitosan either alone or in combination with HPMC for sustained delivery of domperidone. Furthermore, the concentration of the natural polymer and HPMC employed in the formulation need to be carefully selected to enable the production of microspheres with the desired sustained release properties.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43430456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of Geographical Origin and Production Method of L(+)-Tartaric Acid by Isotopic Analyses with Chemometrics L(+)-酒石酸地理来源及生产方法的同位素化学计量学研究
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.001
G. D. Leirose, M. Grenier-loustalot, A. H. Oliveira
The determination of the geographical origin as well as the adulteration of natural products is a technical problem due to similar chemical composition between an adulterant and the original. It is assumed that tartaric acid comes from natural sources, however there is no specific regulation for this claim. This paper describes the use of isotope mass spectrometry associated with chemometrics to classify different samples of tartaric acid. The results showed that the variables δC, δO and δH allowed the discrimination of tartaric acid samples by geographical origin and production method. By using a combination of chemometric analysis it was possible to confirm a notoriousseparation of the samples. Thus, this is a promising method to be applied in the quality control and authenticity of tartaric acid.
天然产品的地理来源以及掺假的确定是一个技术问题,因为掺假物与原物之间的化学成分相似。人们认为酒石酸来自天然来源,但对此没有具体的规定。本文介绍了利用同位素质谱法结合化学计量学对酒石酸的不同样品进行分类。结果表明,δC、δO和δH可以用于酒石酸样品的产地和生产方法鉴别。通过使用化学计量分析的组合,有可能确认样品的臭名昭著的分离。因此,该方法在酒石酸的质量控制和鉴定中具有广阔的应用前景。
{"title":"Investigation of Geographical Origin and Production Method of L(+)-Tartaric Acid by Isotopic Analyses with Chemometrics","authors":"G. D. Leirose, M. Grenier-loustalot, A. H. Oliveira","doi":"10.17265/1934-7375/2017.02.001","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.001","url":null,"abstract":"The determination of the geographical origin as well as the adulteration of natural products is a technical problem due to similar chemical composition between an adulterant and the original. It is assumed that tartaric acid comes from natural sources, however there is no specific regulation for this claim. This paper describes the use of isotope mass spectrometry associated with chemometrics to classify different samples of tartaric acid. The results showed that the variables δC, δO and δH allowed the discrimination of tartaric acid samples by geographical origin and production method. By using a combination of chemometric analysis it was possible to confirm a notoriousseparation of the samples. Thus, this is a promising method to be applied in the quality control and authenticity of tartaric acid.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44033326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of the Internal Structures of Bones by Microtomography 骨内部结构的显微断层扫描比较
Pub Date : 2017-02-28 DOI: 10.17265/1934-7375/2017.02.002
J. C. L. Stutz, J. S. Dominguez, Joaquim Teixeira de Assis
The use of computed microtomography (μCT) has revolutionized many areas of research, such as noninvasive, fast and high precision techniques, which allows immediate visualization of internal structures without any risk to the object of study. μCT is widely accepted for medical diagnostics, is also important for purposes of zoological research and paleontological. In this work, we used the μCT to investigate the internal structure of bones from mammalian and poultry. We studied the bones of rats and quail. Through microtomography images, we observed that the bones of the poultry have a bony structure in the form of a trellis that is not present in bones of mammals. These trellises bony is an evolutionary adaptation that allowed the bones of the birds to become longer and lighter maintaining its strength. It was also observed that the percentage of the trabecular area in poultry is almost half of that observed in mammals. The results obtained validate the use of μCT as a technique that allows the study of bone structures in small samples, enabling to explore the morphological differences between the bones of those species.
计算机微断层扫描(μCT)的使用已经彻底改变了许多研究领域,例如非侵入性,快速和高精度技术,可以立即可视化内部结构,而不会对研究对象造成任何风险。μCT在医学诊断中被广泛接受,在动物学和古生物学研究中也很重要。本研究利用μCT对哺乳动物和家禽骨骼的内部结构进行了研究。我们研究了老鼠和鹌鹑的骨头。通过显微断层扫描图像,我们观察到家禽的骨骼具有一种在哺乳动物骨骼中不存在的网格形式的骨结构。这些网格状的骨头是一种进化适应,使鸟类的骨头变得更长更轻,保持其强度。还观察到,家禽小梁面积的百分比几乎是在哺乳动物中观察到的百分比的一半。这些结果验证了μCT作为一种技术的使用,该技术允许在小样本中研究骨骼结构,从而能够探索这些物种骨骼之间的形态学差异。
{"title":"Comparison of the Internal Structures of Bones by Microtomography","authors":"J. C. L. Stutz, J. S. Dominguez, Joaquim Teixeira de Assis","doi":"10.17265/1934-7375/2017.02.002","DOIUrl":"https://doi.org/10.17265/1934-7375/2017.02.002","url":null,"abstract":"The use of computed microtomography (μCT) has revolutionized many areas of research, such as noninvasive, fast and high precision techniques, which allows immediate visualization of internal structures without any risk to the object of study. μCT is widely accepted for medical diagnostics, is also important for purposes of zoological research and paleontological. In this work, we used the μCT to investigate the internal structure of bones from mammalian and poultry. We studied the bones of rats and quail. Through microtomography images, we observed that the bones of the poultry have a bony structure in the form of a trellis that is not present in bones of mammals. These trellises bony is an evolutionary adaptation that allowed the bones of the birds to become longer and lighter maintaining its strength. It was also observed that the percentage of the trabecular area in poultry is almost half of that observed in mammals. The results obtained validate the use of μCT as a technique that allows the study of bone structures in small samples, enabling to explore the morphological differences between the bones of those species.","PeriodicalId":67212,"journal":{"name":"化学与化工:英文版","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42410278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
化学与化工:英文版
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1