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Retention of the N-nitrosodiethanolamine by hydrophilic interaction liquid chromatography on different polar columns: mechanism study and optimization 亲水相互作用液相色谱法在不同极性色谱柱上保留 N-亚硝基二乙醇胺:机理研究与优化
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-10 DOI: 10.1007/s13738-024-03085-9
Ghazaleh Abedi, Zahra Talebpour, Arezu Hosseiny

To investigate the retention mechanism of N-nitrosodiethanolamine (NDELA) in liquid chromatography, the mobile phase composition was changed on five stationary phases including silica, diol, cyano, amino, and zwitterionic. Afterward, temperature, pH, and buffer concentration effects are studied. Results demonstrate a dual hydrophilic interaction liquid chromatography (HILIC)-reversed phase (RP) mechanism for the retention of NDELA. The transition between the HILIC and RP behavior on a different column, “U-turn” points, was observed between 43 and 68% of water in acetonitrile. The depiction of the natural logarithm of retention factor vs. inverse of the absolute temperature was linear for cyano, amino, and zwitterionic columns. In contrast, it was curvature for silica and diol columns. In each column, the positive slopes indicate a negative retention enthalpy, signifying an exothermic process of transferring analytes from the mobile phase to the stationary phases being examined. In the case of buffer pH and concentration, an ammonium acetate solution with a pH of 5.7 and a concentration of 10 mM was selected for further investigation. Finally, the selectivity of this method in optimal conditions for the analysis of NDELA in shampoo has been investigated. According to the well-obtained selectivity of NDELA in shampoo and the advantages of the HILIC method, this method seems to be a suitable alternative to RP methods.

为研究N-亚硝基二乙醇胺(NDELA)在液相色谱中的保留机理,改变了硅胶、二元醇、氰基、氨基和齐聚物等5种固定相的流动相组成。随后,研究了温度、pH 值和缓冲液浓度的影响。结果表明,亲水相互作用液相色谱(HILIC)和反相色谱(RP)是保留玖龙牌萘乙二胺的双重机制。在不同的色谱柱上观察到 HILIC 和 RP 行为之间的转换,即 "U-turn "点,水在乙腈中的含量为 43% 至 68%。氰基、氨基和齐聚物色谱柱的保留因子自然对数与绝对温度的倒数呈线性关系。相反,硅胶柱和二元醇柱的保留因子呈曲线变化。在每种色谱柱中,正斜率表示负的保留焓,表明分析物从流动相转移到固定相的放热过程。在缓冲液 pH 值和浓度方面,选择了 pH 值为 5.7、浓度为 10 mM 的醋酸铵溶液进行进一步研究。最后,研究了该方法在最佳条件下分析洗发水中 NDELA 的选择性。根据洗发水中 NDELA 的良好选择性和 HILIC 方法的优点,该方法似乎可以替代 RP 方法。
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引用次数: 0
Synthesis, characterization and anti-microbiological evaluation of 2-[(2,6-diaryl piperidin-4-yl)hydrazono]-2,3-dihydrothiazoles as a new class of antimicrobial agents 作为新型抗菌剂的 2-[(2,6-二芳基哌啶-4-基)肼基]-2,3-二氢噻唑的合成、表征和抗微生物学评价
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-09 DOI: 10.1007/s13738-024-03090-y
N. Sarathi, S. L. Ashok Kumar, C. Sankar

A series of 2-[(2,6-diarylpiperidin-4-yl)hydrazono]-2,3-dihydrothiazoles (25–40) were synthesized by the reaction of respective thiosemicarbazones (9–24) with phenacyl bromide in the presence of sodium acetate-acetic acid buffer and refluxing in ethanol for 12–16 h. The newly synthesized target compounds were characterized by elemental analysis, mass, FT-IR, 1H and 13C NMR spectroscopic methods. A Structure activity relationship study was carried out for the title compounds against a panel of bacterial strains viz Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis and Klebsiella pneumonia and the fungal strains Cryptococcus neoformans, Candida albicans, Rhizopus sp, Aspergillus niger and Aspergillus flavus, respectively, using ciprofloxacin and amphotericin-B as standard drugs. These studies proved that compounds 26 and 34 against Staphylococcus aureus, 35 against P. aeruginosa, 38 against B. subtilis, and 27 against K. pneumonia showed maximum inhibitory potency at the lowest concentration (6.25 µg/mL), whereas 26, 34 and 35 against C. neoformans and 26 and 27 against Candida albicans showed beneficial antifungal activity at a minimum concentration (MIC) of 6.25 µg/mL.

一系列 2-[(2,6-diarylpiperidin-4-yl)hydrazono]-2,3-dihydrothiazoles(25-40)是由各自的硫代氨基羰基化合物(9-24)与苯基溴在醋酸钠-醋酸缓冲液中反应并在乙醇中回流 12-16 小时合成的。针对一系列细菌菌株,即金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌、伤寒沙门氏菌、枯草芽孢杆菌和克雷伯菌,对标题化合物进行了结构活性关系研究、以环丙沙星和两性霉素-B 为标准药物,分别对新型隐球菌、白色念珠菌、根霉菌、黑曲霉和黄曲霉等细菌菌株和真菌菌株进行了研究。这些研究证明,针对金黄色葡萄球菌的化合物 26 和 34、针对铜绿假单胞菌的化合物 35、针对枯草杆菌的化合物 38 以及针对肺炎双球菌的化合物 27 在最低浓度(6.25 微克/毫升)下显示出最大抑制效力,而针对新变形杆菌的化合物 26、34 和 35 以及针对白色念珠菌的化合物 26 和 27 在最低浓度(MIC)为 6.25 微克/毫升时显示出有益的抗真菌活性。
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引用次数: 0
Design, synthesis, biological evaluation and molecular docking studies of thiophene derivatives 噻吩衍生物的设计、合成、生物学评价和分子对接研究
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-07 DOI: 10.1007/s13738-024-03088-6
Rashmi Shah, Prabhakar Kumar Verma, Manisha Shah, Satendra Kumar

A series of 1-(2-amino-2,4,5,6,7,7a-hexahydrobenzo[b]-3-yl)-3-substitued-phenylpropane-1,3-dionederivatives were synthesized using the Gewald synthesis in first step which is followed by Baker−Venkataraman rearrangement to yield title compounds. The FTIR, MS and 1H NMR results of the produced derivatives were validated. The biological potential such as antimicrobial, antioxidant and antimycobacterial activity against a particularly virulent strain of MTB (MTB H37Ra) of the synthesized compounds were examined. Antimicrobial screening outcomes showed that compound S17 turned to be the most effective antibacterial agent against Gram positive bacteria such as Staphylococcus aureus (MIC = 16.87 µM) and Bacillus subtilis (MIC = 9.45 µM) and Gram negative bacteria such as Escherichia coli (MIC = 16.87 µM) and compound S7 against Salmonella typhi (MIC = 9.74 µM) and compound S16 displayed remarkable antifungal activity toward each Candida albicans and Aspergillus niger (MIC = 15.23 µM). The standard drugs, cefadroxil (antibacterial), have MIC value against S. aureus, B. subtilis, E. coli and S. Typhi are 16.40 µM, 32.80 µM, 16.40 µM and 16.40 µM, respectively, and fluconazole (antifungal) has MIC value 20.40 µM against both the C. albicans and A.niger strain. In comparison with ascorbic acid, a standard drug (IC50 44.91 µg/mL), compound S10 demonstrated good antioxidant activity, with an IC50 value of 45.29 µg/mL, according to the results of the antioxidant screening. The results of the in vitro antituberculosis screening showed that compound S23 was found to be effective with an MIC value of 78.125 µg/mL. Molecular docking study of an enzymatic active site of “DprE1-decaprenylphosphoryl-β-D-ribose-2′-epimerase” shows a comparable binding mode to the native ligand with better docking score which contributes in understanding and development of models for ligand–protein interactions. Compound S23 showed better docking score of − 8.516 as compared to the Isoniazid with the docking score of − 6.315 which in future will create the fundamental structural framework for MTB inhibition.

Graphic abstract

研究人员采用 Gewald 合成法合成了一系列 1-(2-氨基-2,4,5,6,7,7a-六氢苯并[b]-3-基)-3-取代苯基丙烷-1,3-二酮衍生物,第一步通过 Baker-Venkataraman 重排反应生成了标题化合物。生成的衍生物的傅立叶变换红外光谱、质谱和 1H NMR 结果均得到验证。研究人员还考察了合成化合物的生物潜力,如抗菌、抗氧化和抗霉菌活性,这些化合物对一种毒性特别强的 MTB 菌株(MTB H37Ra)具有抗菌、抗氧化和抗霉菌活性。抗菌筛选结果表明,化合物 S17 对金黄色葡萄球菌(MIC = 16.87 µM)和枯草杆菌(MIC = 9.45 µM)和革兰氏阴性菌如大肠杆菌(MIC = 16.87 µM)的抗菌剂,化合物 S7 对伤寒沙门氏菌(MIC = 9.74 µM)的抗菌剂,化合物 S16 对白色念珠菌和黑曲霉(MIC = 15.23 µM)均显示出显著的抗真菌活性。标准药物头孢羟氨苄(抗菌)对金黄色葡萄球菌、枯草杆菌、大肠杆菌和伤寒杆菌的 MIC 值分别为 16.40 µM、32.80 µM、16.40 µM 和 16.40 µM,氟康唑(抗真菌)对白色念珠菌和黑曲霉菌株的 MIC 值均为 20.40 µM。根据抗氧化筛选结果,与标准药物抗坏血酸(IC50 值为 44.91 µg/mL)相比,化合物 S10 表现出良好的抗氧化活性,IC50 值为 45.29 µg/mL。体外抗结核筛选结果表明,化合物 S23 有效,其 MIC 值为 78.125 µg/mL。对 "DprE1-脱癸烯酰基磷酰-β-D-核糖-2′-epimerase "酶活性位点的分子对接研究表明,化合物 S23 的结合模式与原生配体相似,且对接得分更高,这有助于理解和开发配体与蛋白质相互作用的模型。化合物 S23 的对接得分为-8.516,而异烟肼的对接得分为-6.315,两者相比,化合物 S23 的对接得分更高,这将为今后抑制 MTB 建立基本的结构框架。
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引用次数: 0
Mono-doped (X = S2−, Se2−, and Te2−) and co-doped (Zr4+-X) TiO2 monolayer nanosheet for water splitting: DFT modeling 用于水分离的单掺杂(X = S2-、Se2- 和 Te2-)和共掺杂(Zr4+-X)TiO2 单层纳米片:DFT 建模
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-09-06 DOI: 10.1007/s13738-024-03096-6
Nasim Orangi, Hossein Farrokhpour

The water splitting activity of (111) TiO2 monolayer nanosheet and its mono and co-doped forms has been investigated by the periodic density functional theory (DFT) calculations. Upon Zr4+ mono-doping and even increasing the concentration of Zr4+ dopant, the band gap of the (111) TiO2 monolayer becomes wider than that of the corresponding pure monolayer (3.9 eV), which reduces the photocatalytic efficiency. Fortunately, (S2−, Se2−, and Te2−) mono-doping and their increased concentration can effectively decrease the band gap by introducing midgap states above the valence band edge for the relevant monolayers. Moreover, the (Zr4+-S2−), (Zr4+-Se2−), and (Zr4+-Te2−) co-doping leads to a narrowed band gap and enhances the visible-light photoactivity of the (111) TiO2 monolayer. Among considered monolayers, the Te2−-doped and (Zr4+-Te2−) co-doped (111) TiO2 monolayers are the most desirable photocatalysts for hydrogen generation in this work.

通过周期性密度泛函理论(DFT)计算研究了(111) TiO2单层纳米片及其单掺杂和共掺杂形式的分水活性。当 Zr4+ 单掺杂甚至增加 Zr4+ 掺杂浓度时,(111) TiO2 单层的带隙比相应的纯单层(3.9 eV)更宽,从而降低了光催化效率。幸运的是,(S2-、Se2- 和 Te2-)单掺杂及其浓度的增加可以通过为相关单层引入价带边缘以上的中隙态而有效降低带隙。此外,(Zr4+-S2-)、(Zr4+-Se2-)和(Zr4+-Te2-)共掺杂会导致带隙变窄,并增强 (111) TiO2 单层的可见光光活性。在所考虑的单层中,掺杂Te2和(Zr4+-Te2-)共掺杂的(111)TiO2单层是本研究中最理想的制氢光催化剂。
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引用次数: 0
Novel acidic deep eutectic solvents: synthesis, phase diagram, thermal behavior, physicochemical properties and application 新型酸性深共晶溶剂:合成、相图、热行为、理化性质和应用
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-30 DOI: 10.1007/s13738-024-03077-9
Aso Kianpoor, Rahmat Sadeghi

Three new binary acidic deep eutectic solvents (DESs) were derived from tetrabutylammonium bromide (TBAB) as a hydrogen bond acceptor (HBA) coupled with azelaic acid (AzA), benzilic acid (BeA) and boric acid (BoA) as hydrogen bond donors (HBD). In order to draw the complete phase diagram and find the molar ratios in which the DESs are formed, HBA and HBDs were mixed together in the full range of molar ratios and their thermal behavior (by differential scanning calorimetry method) and stability were investigated. The activity coefficient models including Wilson, NRTL and regular solution were applied to correlate the measured solid–liquid equilibrium data. FT–IR and NMR analysis were used to investigate the chemical structures, occurrence the hydrogen bond formation between the DESs constituents and purity of the prepared DESs. Physicochemical properties of these DESs including melting point, density, and speed of sound, conductivity and refractive index were measured at different temperatures. The performance of these new DESs were successfully evaluated for the dissolution of four metal oxides including PbO, CuO, Fe2O3 and ZnO and the obtained solubility values were compared with the reported literature data.

以四丁基溴化铵(TBAB)为氢键接受体(HBA),壬二酸(AzA)、苯齐酸(BeA)和硼酸(BoA)为氢键供体(HBD),衍生出三种新的二元酸性深共晶溶剂(DES)。为了绘制完整的相图并找到形成 DESs 的摩尔比,我们将 HBA 和 HBD 以各种摩尔比混合在一起,并研究了它们的热行为(采用差示扫描量热法)和稳定性。应用包括 Wilson、NRTL 和常规溶液在内的活度系数模型来关联测得的固液平衡数据。傅立叶变换红外光谱和核磁共振分析用于研究化学结构、DESs 成分之间氢键的形成以及所制备 DESs 的纯度。在不同温度下测量了这些 DES 的物理化学特性,包括熔点、密度、声速、电导率和折射率。成功评估了这些新型 DES 在溶解四种金属氧化物(包括 PbO、CuO、Fe2O3 和 ZnO)方面的性能,并将所获得的溶解度值与所报道的文献数据进行了比较。
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引用次数: 0
Synthesis, fluorescence, enzymes effects, and evaluation of tetrahydroxy substituted zinc phthalocyanine as multitarget metabolic enzyme inhibitors with molecular docking: the biochemistry-oriented drug design 四羟基取代锌酞菁作为多靶点代谢酶抑制剂的合成、荧光、酶效应和分子对接评估:以生物化学为导向的药物设计
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-27 DOI: 10.1007/s13738-024-03079-7
Derya Güngördü Solğun, Nastaran Sadeghian, Tugba Taskin-Tok, Mehmet Salih Ağirtaş, Parham Taslimi

Synthesis and properties of tetrahydroxy substituted zinc phthalocyanine is reported. UV–Visible spectrum for the aggregation properties of the compound and fluorescence properties were examined by excitation, emission spectra. This complex was an inhibitor of butyrylcholinesterase (BChE), α-Gly, α-Amy, and acetylcholinesterase (AChE) enzymes for tetra- hydroxy phthalocyaninato zinc (II) 3 with IC50 values of 49.18 μM for α-Amy, 110.85 μM for BChE, 35.13 μM for α-glycosidase and 54.63 μM for AChE, respectively. On the otherside, within the scope of computational study, in vitro activity behavior and states of the related complex, which cannot be explained experimentally, were evaluated at atomic level. The pharmacodynamics properties of the complex (3) were elucidated by molecular docking against four target enzymes, AChE, BChE, α-Gly and α-Amy. After that, its potential drug candidate was investigated based on its pharmacokinetic properties with help of in silico-ADMET analysis. As a result of all the applications, a desired goal in medicinal chemistry was to develop new, reliable and safe cholinesterase and α-glycosidase inhibitors with high efficacy.

报告了四羟基取代锌酞菁的合成和特性。紫外可见光谱显示了该化合物的聚集特性,激发光谱和发射光谱显示了其荧光特性。该复合物是丁酰胆碱酯酶(BChE)、α-甘氨酸、α-氨酰胆碱酯酶和乙酰胆碱酯酶(AChE)的抑制剂,其 IC50 值分别为:α-氨酰胆碱酯酶为 49.18 μM,BChE 为 110.85 μM,α-糖苷酶为 35.13 μM,AChE 为 54.63 μM。另一方面,在计算研究的范围内,在原子水平上对相关复合物的体外活性行为和状态进行了评估,这些都是实验无法解释的。通过与 AChE、BChE、α-Gly 和 α-Amy 四种靶酶的分子对接,阐明了复合物 (3) 的药效学特性。随后,在硅-ADMET 分析的帮助下,根据其药代动力学特性对其潜在候选药物进行了研究。通过所有这些应用,药物化学的预期目标是开发出新的、可靠的、安全的、高效的胆碱酯酶和α-糖苷酶抑制剂。
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引用次数: 0
The effect of terminal halogen atom on the self-assembly of bisthienylethene-based rod-like molecules 末端卤素原子对双噻吩基棒状分子自组装的影响
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-26 DOI: 10.1007/s13738-024-03087-7
Ying Pu, Yurun Liang, Xiuning Hu, Guoyi Li, Binli Deng, Xiaotong Liu, Yulong Xiao

Three novel rod-like molecules containing a bisthienylethene as π-conjugate rigid core with a different type of terminal functional atom (H, Cl, Br) were constructed by using Suzuki coupling and Knoevenagel reactions. The effect of the terminal functional atom on self-assembly behaviors in both bulk state and solution states and solid structures was investigated by using differential scanning calorimetry, polarized optical microscopy, small-angle X-ray scattering diffraction, density functional theory calculations and field-emission scanning electron microscopy. The non-halogen substituted compound and chlorinated compound are non-mesogen, whereas the brominated compound can self-assemble into a monotropic single-layer smectic A phase. The non-halogen substituted compound cannot form organogel in the common organic solvents, the chlorinated compound can form yellow-green fluorescent oragnogels in ethyl acetate and acetone, with rod-like morphology and brominated compound can form yellow-green, yellow or orange fluorescent oragnogels in ethyl acetate, acetone, 1,4-dioxane and toluene with sheet-like morphology. In addition, the terminal halogen atom induced great changes in the orderliness of solid morphology. Therefore, tuning terminal halogen atom could well lead to the transition of self-assembly behaviors in bulk state and solution state, which provides a way to obtain different self-assembly materials.

利用铃木偶联反应和克诺文纳格尔反应,构建了三种新型棒状分子,它们以双噻吩为π-共轭刚性核心,具有不同类型的末端官能团(H、Cl、Br)。利用差示扫描量热法、偏振光学显微镜、小角 X 射线散射衍射、密度泛函理论计算和场发射扫描电子显微镜研究了末端官能团原子对体态和溶液态自组装行为以及固体结构的影响。非卤素取代的化合物和氯化化合物都是非介质,而溴化化合物则可以自组装成单向性的单层 Smectic A 相。非卤素取代的化合物不能在普通有机溶剂中形成有机凝胶,氯化化合物可在乙酸乙酯和丙酮中形成具有杆状形态的黄绿色荧光有机凝胶,溴化化合物可在乙酸乙酯、丙酮、1,4-二氧六环和甲苯中形成具有片状形态的黄绿色、黄色或橙色荧光有机凝胶。此外,末端卤素原子会导致固体形态的有序性发生巨大变化。因此,调整末端卤素原子可以很好地导致体态和溶液态自组装行为的转变,为获得不同的自组装材料提供了途径。
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引用次数: 0
Response surface method Box-Behnken design-based optimization of organic fertilizer enrichment using bat guano 基于响应面法的箱-贝肯设计,利用蝙蝠粪优化有机肥增效
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-23 DOI: 10.1007/s13738-024-03083-x
Jülide Erkmen

Agricultural environmental pollution needs to be reduced in our future. The biggest obstacles to preventing this situation are that agricultural inputs such as synthetic fertilizers increase product yield and scattered agricultural areas. This study involves the optimization of the production process of an easy-to-apply organic fertilizer with high nutritional value by subjecting bat guano, one of the valuable organic fertilizers, to anaerobic digestion together with cattle manure. Response surface method Box-Behnken design, a statistical model, was used for process optimization. The process input parameters were temperature, cattle manure, and bat manure, and the response value was considered as 2% total nitrogen. As a result of the optimization for a total nitrogen value of 2%, the optimum mixture ratio was determined as cattle manure 77.0448%, bat manure 12%, and temperature 40 °C. Analysis results showed that the addition of bat manure increased the N, P, K, and humic and fulvic acid values in the fertilizer. The study revealed that strong organic fertilizers can be used to increase the value of cattle manure organically. It also offers very promising results based on reducing agricultural pollution and ensuring agricultural sustainability.

未来需要减少农业环境污染。防止出现这种情况的最大障碍是农业投入(如合成肥料)会增加产品产量和分散农业区域。本研究通过将宝贵的有机肥料之一蝙蝠粪与牛粪一起进行厌氧消化,优化了一种营养价值高、易于施用的有机肥料的生产工艺。采用响应面法 Box-Behnken 设计(一种统计模型)进行工艺优化。工艺输入参数为温度、牛粪和蝙蝠粪,响应值为总氮的 2%。针对 2%的总氮值进行优化后,确定最佳混合比例为牛粪 77.0448%、蝙蝠粪 12%、温度 40 °C。分析结果表明,添加蝙蝠粪增加了肥料中的氮、磷、钾、腐殖酸和富里酸值。这项研究表明,可以使用强效有机肥料有机地提高牛粪的价值。在减少农业污染和确保农业可持续发展的基础上,它还提供了非常有前景的结果。
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引用次数: 0
Synthesis of novel quinazolinone-triheterocyclic hybrides as dual inhibition of urease and ache 合成新型喹唑啉酮-三杂环杂化物作为脲酶和胃酸的双重抑制剂
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-21 DOI: 10.1007/s13738-024-03080-0
Emre Menteşe, Yeter Ünal Güzel, Gülay Akyüz, Nesrin Ünal Karaali

New triheteroyclic compounds containing quinazolinone, thiophene, andthiadiazole /thiazolidinone structureswere synthesized and characterized by FT-IR, 1H–NMR, and13C–NMRspectral data. The new compounds’ inhibitory activities on urease and acetylcholinesterase were assessed. All triheterocyclic compounds with thiadiazole ring have urease and acetylcholinesteraseinhibitory activities.Especially compound 5a; 3-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl]methyl-2-(thiophen-3-ylmethyl)quinazolin-4(3H)-onehas the best urease inhibition result with 13.30 ± 0.15 µg/mL IC50 value, and it also has the best acetylcholinesterase inhibition with 20.30 ± 0.15 µg/mL IC50 value.

合成了含有喹唑啉酮、噻吩和噻二唑/噻唑烷酮结构的新的三杂环化合物,并通过傅立叶变换红外光谱、1H-NMR 和 13C-NMR 光谱数据对其进行了表征。评估了新化合物对脲酶和乙酰胆碱酯酶的抑制活性。特别是化合物 5a;3-[(5-(苯基氨基)-1,3,4-噻二唑-2-基]甲基-2-(噻吩-3-基甲基)喹唑啉-4(3H)-酮对尿素酶的抑制效果最好,为 13.它对乙酰胆碱酯酶的抑制效果也最好,IC50 值为 20.30 ± 0.15 µg/mL。
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引用次数: 0
Study on Eu3+-doped MgAl-LDH as carrier of chlorogenic acid and their fluorescent property 作为绿原酸载体的 Eu3+ 掺杂 MgAl-LDH 及其荧光特性研究
IF 2.2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2024-08-19 DOI: 10.1007/s13738-024-03081-z
Xiaoqiang Shang, Tingting Li, Fang Guo, Yijun Liu, Yufeng Chen

Since drug release behavior depends on the interaction between the drugs and carriers, the present work is to study the drug delivery system based on magnesium aluminum layered double hydroxides containing europium (MgAl-Eu-LDH) for chlorogenic acid (CGA). Various characterizations, including X-ray diffraction (XRD), infrared spectrum, zeta potentials, UV–Vis absorption spectrum, scanning electron scanning electron microscope equipped with energy-dispersive X-ray spectroscopy (SEM–EDS), CHN elemental analysis, and fluorescent spectra, were employed to investigate the drug delivery system. Results revealed that the CGA was loaded into MgAl-Eu-LDH. The drug delivery system based on MgAl-Eu-LDH exhibited more slow and sustained release of CGA compared with that of the previous methotrexate or 5-fluorouracil, and the drug release experiment can be reproducible. Moreover, the MgAl-Eu-LDH showed different fluorescence before loading CGA, during loading CGA, and after releasing CGA. These results may provide a reference for the development of CGA drug delivery systems with slow and sustained release.

由于药物释放行为取决于药物和载体之间的相互作用,本研究工作旨在研究基于含铕的镁铝层状双氢氧化物(MgAl-Eu-LDH)的绿原酸(CGA)给药系统。研究采用了多种表征方法,包括 X 射线衍射 (XRD)、红外光谱、ZETA 电位、紫外可见吸收光谱、配备能量色散 X 射线光谱仪的扫描电子显微镜 (SEM-EDS)、CHN 元素分析和荧光光谱,来研究该给药系统。结果表明,CGA 被负载在 MgAl-Eu-LDH 中。与之前的甲氨蝶呤或 5-氟尿嘧啶相比,基于 MgAl-Eu-LDH 的给药系统能更缓慢、更持久地释放 CGA,且药物释放实验具有可重复性。此外,MgAl-Eu-LDH 在装载 CGA 之前、装载 CGA 期间和释放 CGA 之后显示出不同的荧光。这些结果可为开发缓释和持续释放的 CGA 给药系统提供参考。
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Journal of the Iranian Chemical Society
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