Journal of the Iranian Chemical Society最新文献

The degradation of dyes in the wastewater from the industrial wastes has been an environment concern with the rapid industrialization of the economy, requiring the need for the development of dye degradation strategies. In the present work, we employed a facile sol–gel method for the synthesis of Cr-doped bismuth ferrite (BFO) nanoparticles. The as-prepared nanoparticles were exploited to degrade the Eosin-Y dye under visible light irradiation. The XRD measurement confirmed the formation of pure phase BiFeO₃ nanoparticles, with average crystallite size varying from 32.13 to 17.38 nm for pristine and 5% Cr-doped BFO samples, respectively. The XPS measurements were performed to ascertained the chemical state of the elements present in the BFO sample. The band gap of BFO was observed to evolve from 2.12 to 2.18 eV with Cr doping, indicating high light absorbing capability particularly within the visible spectrum. SEM and TEM was used to examine the morphological characteristics of the prepared samples. The photocatalytic degradation of the Eosin-Y dye was investigated under visible light with the doped as well as the undoped samples. A highest photodegradation efficiency of 80.6% for the time period of 75 min have been achieved for the 5% Cr-doped BFO samples. This work provides a new insight for the application of Cr-doped BFO nanoparticles for the remediation of industrial wastewater.

The formation, accumulation, and deposition of proteins aggregates are fundamental pathological characteristics underlying various disease states. Thus, the discovery and development of innovative compounds capable of impeding amyloid formation and mitigating its associated toxicity represent a highly promising therapeutic strategy. This study focused on developing a series of 2‐Amino‐4‐(phenyl) ‐3‐cyano‐4H,5H-pyrano[3,2‐c] chromene‐5‐one derivatives as multitargeted directed ligands (MTDLs) for inhibition of amyloid aggregation. The compounds were evaluated for their capacity to hinder amyloid formation by hen egg white lysozyme (HEWL), a well-established model protein for amyloid investigations. The inhibitory impact of the compounds was assessed through a range of methods, such as Congo red and Thioflavin T binding assays, atomic force microscopy, and cell-based cytotoxicity assays. The results provide compelling evidence that all tested compounds effectively inhibit HEWL amyloid fibril formation and reduce its associated cytotoxicity with different efficiencies. Our investigation reveals those hydrophobic substituents, such as -O-Methyl and -NO₂, significantly enhance the inhibitory potential of our compound's basic structure, while the presence of -Br diminishes it. Methoxy and nitro substituents exhibit a greater affinity for participating in hydrogen bonding, potentially leading to an augmented inhibitory efficacy when compared to bromo derivatives. The results highlight the importance of hydrophobicity, aromaticity, and hydrogen bonding capability in determining the amyloid inhibition activity exhibited by our compounds. These findings provide valuable insights for future rational designs of amyloid inhibitors for potential therapeutic interventions in amyloid-associated diseases.

The development of natural adsorbents that are abundant, cost-effective, and efficient for the treatment of ecosystems is a significant challenge. In this study, the sorption of Congo red, as a toxic dye, from aqueous media was investigated using an Algerian clay sample from the western town of Maghnia as a low-cost adsorbent that has undergone simple purification. Different parameters such as contact time (5–120 min), initial dye concentration (5–20 mg/L), solution pH (4–12), adsorbent weight (10–100 mg), and temperature (15–50 °C) have been investigated. The equilibrium (9.8 mg g⁻¹) was obtained for a contact time of 60 min, and the maximum sorption occurred at pH 8.5. The adsorption kinetic followed the pseudo-second-order kinetic model with a high degree of correlation coefficient (R² = 0.99). The adsorption isotherm showed an appropriate fit to the Freundlich model. Thermodynamic investigations revealed that the adsorption process is feasible, spontaneous, and endothermic. These results demonstrate that Algerian clay can be employed as a low-cost alternative for the removal of recalcitrant dyes from industrial wastewater.

Acarbose, miglitol and voglibose are α-glucosidase enzyme inhibitors that are clinically used to treat type-II diabetes mellitus. However, they are also associated with several adverse side effects. In this study, a series of sulfonamide-substituted coumarin was synthesised in a three-step reaction from precursor, 2-oxo-2H-chromene-3-carboxylic acid. The structure of all synthesised compounds was confirmed using NMR, FTIR and LCMS analysis and found to be in good agreement with the calculated values. Synthesised coumarin derivatives were screened for their in vitro α-glucosidase inhibitory activity. Besides compound 8, 15 compounds demonstrated good to excellent inhibitory activity with the IC₅₀ values ranging from 40.6 to 2021 µM as compared to acarbose (IC₅₀ = 3410 ± 1.54 µM). A structure–activity relationship was established to form correlation of the substituents effect with inhibitory activity. It was found that chlorine substituent played an important role in the activity compared to other halogen substituents. Derivatives showing inhibition activity were subjected to docking studies to identify the binding modes contributing towards the inhibition activity.

Nitrogen-containing heterocyclic compounds (NCHCs) have an important role in the field of medicinal chemistry due to their extensive biological activities and their prevalence in natural compounds, pharmaceuticals, and materials science. Here, we have reviewed the recent advancements in the formulation of NCHCs via multicomponent reactions (MCRs). These reactions, which allow the efficient and eco-friendly formulation of complex molecules, have revolutionized the synthesis of heterocycles such as triazoles, imidazoles, pyrazoles, pyrimidines, and pyridazines. This review has further emphasized the key MCR strategies, including the Biginelli, Ugi, Hantzsch, and Passerini reactions, highlighting their mechanisms, scope, and applications in drug discovery. Finally, we have emphasized the biological evaluation of synthesized NCHCs possessing several pharmacological features like antiallergic, anti-inflammatory, anticancer, antimicrobial, neurological, and analgesic activities. The synthesis of specific NCHC scaffolds and their structure–activity relationships are also explored, emphasizing the significance of these compounds in the development of novel therapeutics.

A novel dispersive magnetic micro-solid-phase extraction (DM-µ-SPE) method based on the magnetic NiFe₂O₄ polyamidoamine dendrimers modified with deep eutectic solvent sorbent has been developed for the extraction of naproxen and nabumetone. The extracted analytes were quantified by a high-performance liquid chromatographic (HPLC) method with UV detection at 280 nm. The linearity was in the range of 1–400 µg L⁻¹ for naproxen and 3–400 µg L⁻¹ for nabumetone. The developed DM-µ-SPE/HPLC–UV method has been characterized by excellent intra- and inter-day repeatability of 2.3, 3.3, and 2.5, 4.0%, respectively, for naproxen and nabumetone at the concentration level of 70.0 µg L⁻¹ (n = 5). Enhancement factors of 157.7 and 151.8 and limit of detections of 0.15 µg L⁻¹ and 0.26 µg L⁻¹ for naproxen and nabumetone were achieved, respectively. The sorption isotherm study illustrated that the experimental data of NAP fitted better to the Langmuir isotherm with a maximum monolayer sorption capacity of 76.92 mg g⁻¹, while the NAB data fitted to the Temkin isotherm model. The method was successfully applied to the determination of non-steroidal anti-inflammatory drug analytes in water and milk samples.

Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well defined as a therapy for preventing diabetic polyneuropathies, scavenges free radicals, chelates metals, and restores intracellular glutathione levels which otherwise decline with age.

Sodium zinc histidine dithiooctanamide (DHL-HisZn_Na) is a water-soluble substance, with strong antioxidant and anti-inflammatory properties, similar to α-lipoic acid with histidine bound to α-lipoic acid and zinc chelated with sulfur atoms. DHL-HisZn_Na slowly loses its stability under dry conditions in the dark and under refrigeration. Purification is essential for use after long-term storage. In this study, ethanol crystallization and suspension methods were utilized in development for the first time as purification methods for DHL-HisZn_Na.

Tin sulfide (SnS) semiconductors have become emerging sensor materials for the electrochemical sensing of heavy metals in trace amounts due to their supportive electrochemical properties. This study reports the synthesis, characterization of SnS/rGO composites and sensing of mercury and lead ions in an aqueous solution. SnS/rGO composites with the proper loading of rGO concentration were synthesized using simple solvothermal method and applied for sensing the heavy metals of mercury and lead ions. The synthesized samples were characterized by XRD, FE-SEM, TEM, FTIR and Raman spectroscopy to study the structure and morphology of the samples. Cyclic voltammetry and AC impedance were used to characterize the samples for electrochemical detection of toxic metals Hg and Pb ions. The XRD analysis reveals that the average crystallite of SnS/rGO nanoplates is in the range of 56–67 nm and was confirmed by TEM. FE-SEM analysis reveals the formation of nanoplates on rGO sheets. Raman spectroscopy and FTIR analysis confirm the presence of rGO and the composition of the prepared sample. The electrochemical sensing of SnS and SnS/rGO nanoplates with graphite powder in 0.1 M KOH solution showed good reversibility and was applied for sensing of HgCl₂ and PbCl₂ with a quick response time of 2 s. The LOD for Hg and Pb ions was found to be 47.3–65.3 ppm, respectively. All the prepared electrodes of SnS and SnS/rGO composites could be effectively supported by the electrochemical sensing response to HM ions in alkali medium.

Remdesivir (RDV) is a drug that exhibits broad-spectrum antiviral against RNA viruses, and so this drug could be an appropriate therapeutic candidate. To increase the therapeutic efficiency of Remdesivir, nanoparticles are employed to prolong bioavailability and facilitate targeted delivery in the body and the drug transportation. In this study, we employed classical atomistic molecular dynamics simulations to characterize the adsorption properties of this compound on Ag nanoparticles. The simulation results show that Remdesivir molecules adsorb onto the surface of Ag nanoparticles in a size-dependent manner, so that smaller AgNPs exhibit a higher degree of Remdesivir coating than larger ones. The results also show that the coating of Remdesivir molecules on nanoparticles can improve their pharmacokinetic properties in vivo studies. These findings provide a basis for designing nanoparticle-based drug delivery systems.

A lot of research is focused on creating novel chemotherapeutic medicines since cancer is becoming a more serious concern. In the present investigation, we have developed some quinolinyl–benzothiazolyl linked with amino acids and their anticancer efficacy against melanoma and breast cancer cells evaluated. All the compounds evaluated for in silico studies towards the target protein Human estrogen receptor (PDB: 2IOK). Out of all the evaluated aminoacids conjugates four compounds 5b, 5 k, 5f, and 5d exhibited remarkable docking scores and were chosen for in vitro anticancer studies. Out of which 5 k, and 5f exhibited good anticancer properties with the IC₅₀[μg/mL] of 22.9 and 22.3 respectively against the melanoma cell line and 5b exhibited good anticancer properties with the IC₅₀[μg/mL] of 61.0 against breast cancer cell.

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