Advances in integrative medicine最新文献_第8页

The importance of constructing an osteopathic profession around modern common academic values and avoiding pseudoscience: The Spanish experience 围绕现代共同学术价值观建设骨科专业，避免伪科学西班牙经历

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-09-01 DOI: 10.1016/j.aimed.2023.09.003

Antonio Ciardo , Mar García Sánchez , Moisés Cobo Fernández

Introduction

The global health and wellness industry has an estimated value of $4 trillion USD, of which traditional and complementary medicine (osteopathy included) represent $359.7 billion USD (almost 9 %). While some European countries are gradually recognizing osteopathy as an independent health profession and regulating it in a timely manner, in Spain, osteopathy characterized by a lack of consensus within the professional community itself and the lack of regulation. In February 2019, the Government of Spain launched a campaign (#coNprueba) that was part of the "Plan against pseudotherapies and pseudosciences". In Spain, there is a serious possibility that it will be banned or that osteopathy will be classified as a subspecialization of other health professions (despite this contravening existing national laws). This could set a dangerous precedent for those countries where osteopathy is in the process of being recognized, as it could paralyze such implementation.

Aim

The aim is to understand how it might be possible to change this trend to promote the education of new osteopaths, foster a culture of research, and obtain regulated status. A narrative report based on the literature addresses current issues, including sources of debate and controversy.

Discussion/conclusion

The hand of osteopathy is outstretched to define a collaborative strategy in defence of a freely accessed, plural, safe, and regulated profession in Spain. Spain's own efforts could help the international osteopathy community define its niche and identity and determine the most flexible way to combine tradition and modernity.

全球健康和保健产业估计价值4万亿美元，其中传统和补充医学(包括整骨疗法)占3597亿美元(近9%)。虽然一些欧洲国家逐渐认识到整骨疗法是一种独立的健康职业，并及时对其进行监管，但在西班牙，整骨疗法的特点是在专业社区内部缺乏共识，缺乏监管。2019年2月，西班牙政府发起了一项运动(#coNprueba)，这是“打击假疗法和伪科学计划”的一部分。在西班牙，它很有可能被禁止，或者整骨疗法将被归类为其他卫生专业的一个分支(尽管这违反了现有的国家法律)。这可能会为那些正在承认整骨疗法的国家树立一个危险的先例，因为它可能会使这种疗法的实施陷入瘫痪。目的是了解如何可能改变这一趋势，以促进新骨科医生的教育，培养研究文化，并获得监管地位。基于文献的叙述性报告解决了当前的问题，包括辩论和争议的来源。在西班牙，整骨疗法的手被伸出来定义一种合作策略，以捍卫自由获取、多元、安全和规范的职业。西班牙自己的努力可以帮助国际整骨疗法界确定其定位和身份，并确定结合传统与现代的最灵活的方式。

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引用次数: 0

Use of Bach flower remedies in children and adolescents with attention deficit hyperactivity disorder: Systematic review and meta-analysis 巴哈花疗法在儿童和青少年注意缺陷多动障碍中的应用:系统回顾和荟萃分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-09-01 DOI: 10.1016/j.aimed.2023.07.001

Fernanda Nascimento de Oliveira , Cristina Eunice Okuyama , Audrey de Souza Marquez , Karen Barros Parron Fernandes , Paulo Victor Carpaneze Dalaqua , Andréia Cristina Feitosa do Carmo , Fátima Cristina Alves Branco-Barreiro

Objective

To systematically review the available evidence of the effect of Bach flower remedies (BFR) on the improvement of symptoms and behavior in children and adolescents with attention deficit hyperactivity disorder (ADHD).

Methods

This systematic review with meta-analysis was developed following PRISMA recommendations and the protocol was registered in PROSPERO. The search for controlled trials was performed in Cochrane Central Register of Controlled Trials, Embase, PubMed and LILACS and in grey literature from their inceptions until March, 2023. The population was children and adolescents diagnosed with ADHD. The intervention included the use BFR and the control included placebo or conventional therapies group. The outcome included improvement of symptoms and behavior. RoB 2.0 was used to assess the risk of bias, while GRADE was used to assess the quality of evidence. Stata version 16.0 was used to perform the meta-analysis.

Results

Of the 457 studies identified, only 4 studies that met the inclusion criteria remained and were included in the data analysis. The agreement between the reviewers for risk of bias assessment, based on the kappa statistic, was 0.91. Three studies reported improvement in ADHD symptoms with BFR. The studies presented some concerns regarding the risk of bias and the quality of evidence was “low”. The meta-analysis showed a positive effect favoring BFR (z = 2.57, p = 0.01) versus control with an effect size of 0.80 (0.19–1.42:95 %CI). I² test value was 35.96 %, indicating moderate heterogeneity among the studies.

Conclusions

BFR can have some effect on ADHD. However, further studies with higher methodological quality and long-term follow-up period are needed to reinforce these findings.

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引用次数: 0

Benefits from a plant-based diet, intermittent fasting and aspects of ayurvedic nutrition in rheumatoid arthritis – A case report 植物性饮食、间歇性禁食和阿育吠陀营养对类风湿关节炎的益处——一个病例报告

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-09-01 DOI: 10.1016/j.aimed.2023.07.003

Anika Rajput Khokhar , Kirsten Karberg , Christian S. Kessler

Background

Rheumatoid arthritis (RA) is one of the most common rheumatologic diseases worldwide causing high morbidity and mortality as well as a high socioeconomic burden. Current medications offer several therapeutic options. Additionally, increasing evidence endorses the beneficial influence of certain diets on the disease activity in RA.

Case presentation

Here we present a case of a female patient with a history of 3 years of active seronegative RA under current medication with prednisolone and methotrexate. Additionally, she received dietary counselling and started a plant-based diet with RA-specific dietary recommendations from Traditional Indian Medicine and intermittent fasting. This dietary regimen included meatless vegetable-based main meals, a high amount of whole food products, home-made food from fresh, organic products, and warm servings. While implementing the dietary recommendations for three years, inflammatory parameters decreased. At a 3-years-follow-up, she was able to cease her pharmacotherapy due to a complete clinical remission of RA disease activity.

Conclusions

This case highlights the value of additional nutritional therapy in RA as well as the potential role of the gut microbiota in the pathogenesis of RA. Well-planned prospective clinical trials are warranted in this promising field of medicine.

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引用次数: 0

Impacts of touch massage on the experience of patients with chronic pain: A non-randomized cluster clinical trial 触摸按摩对慢性疼痛患者体验的影响:一项非随机聚类临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-09-01 DOI: 10.1016/j.aimed.2023.09.004

Gora Da Rocha Rodrigues , Catherine Bollondi Pauly , Monique Boegli , François Curtin , Adrien Anex , Sezen Cekic , Christophe Luthy , Jules Desmeules , Christine Cedraschi

Background

Chronic pain is a major public health problem. Non-pharmacological interventions are increasingly being used as a complement to chronic pain treatment and are strongly recommended. The aim of this study was to evaluate the impact of Touch massage (TM) on the experience of patients with chronic pain hospitalized in a rehabilitation ward.

Method

A non-randomized cluster clinical trial was conducted. Eighty-two participants were included in this study, 39 in the intervention group and 43 in the control group. Participants in both groups received 4 sessions of massage (TM or via a machine) over the course of 2 weeks. For both groups, Patients’ Global Impression of Change (PGIC) in the perception of pain and secondary outcomes (pain intensity, anxiety/depression, patient- provider relationship) were measured at baseline and after the intervention.

Results

There was a small effect (Cohen’s d = 0.42) of the intervention type on the score of the PGIC. Patients who received TM tended to perceive more change than participants who received machine massage. The type of intervention had no effect on the other key variables (pain intensity, anxiety/depression, or patient- provider relationship).

Conclusion

This study shows with a rigorous and pragmatic methodology that TM has a positive impact on the perception of pain relief in patients suffering from chronic pain. TM appears as a useful and well manageable therapy for these difficult to treat patients and somewhat better than machine delivered foot massage.

慢性疼痛是一个主要的公共卫生问题。非药物干预越来越多地被用作慢性疼痛治疗的补充，并被强烈推荐。本研究的目的是评估触摸按摩(TM)对康复病房慢性疼痛住院患者体验的影响。进行了一项非随机群集临床试验。本研究共纳入82名受试者，其中干预组39人，对照组43人。两组的参与者在两周的时间里都接受了4次按摩(TM或通过机器)。对于两组，在基线和干预后测量了患者在疼痛感知和次要结局(疼痛强度，焦虑/抑郁，医患关系)方面的总体变化印象(PGIC)。干预类型对PGIC评分的影响较小(Cohen’s d = 0.42)。接受TM的患者比接受机器按摩的患者更容易感觉到变化。干预类型对其他关键变量(疼痛强度、焦虑/抑郁或医患关系)没有影响。本研究以严谨务实的方法显示，TM对慢性疼痛患者的疼痛缓解感有积极的影响。对于这些难以治疗的患者，TM似乎是一种有用且易于管理的治疗方法，并且比机器提供的足部按摩更好。

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引用次数: 0

Effect of Hatha Yoga and meditation on academic stress in medical students—Clinical trial 哈他瑜伽和冥想对医学生学业压力的影响-临床试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-09-01 DOI: 10.1016/j.aimed.2023.09.001

Sandra Moreno , Lina Becerra , Guillermo Ortega , Milton Fabian Suarez-Ortegón , Freddy Moreno

Introduction

Medical students use to deal with high levels of academic stress. Hatha yoga and meditation have been found to reduce variables associated with stress. Objective: To evaluate and compare the effect of Hatha yoga and meditation on academic stress in medical students at a private university in Cali, Colombia.

Methods and materials

A total of 27 volunteers were randomly divided into two groups: Hatha Yoga(n = 13) and Meditation (n = 14). Each group undertook two weekly one-hour sessions for 14 weeks. Study outcomes were salivary cortisol and perceived academic stress. Anthropometric and clinical variables were additionally measured as characteristics of the study sample. Perceived academic stress was estimated via a structured questionnaire. An intra-group analysis was also conducted to compare the outcomes at baseline and post-intervention within the groups.

Results

At baseline demographic, clinical, and anthropometric variables were similar between the intervention groups. After the intervention, no differences were found between meditation and hatha yoga groups in salivary cortisol measures (time 0, 15, 30, 45 min, and mean of the 4 measures) and perceived academic stress. However, the intra-group analysis showed that only in Hatha yoga there was a significant increase in cortisol measures and improvement in the scale of perceived academic stress.

Conclusion

Based on the intra-group but not between-group comparisons of outcomes at baseline and post-intervention, Hatha yoga reduced perceived academic stress despite a concomitant significant increase in cortisol levels. Further trials with larger samples of medical students should be conducted to contrast our findings.

医学生通常都要应对高水平的学业压力。人们发现，哈他瑜伽和冥想可以减少与压力相关的变量。目的:评价和比较哈达瑜伽和冥想对哥伦比亚卡利一所私立大学医学生学业压力的影响。共有27名志愿者被随机分为两组:哈他瑜伽(n=13)和冥想(n=14)。每个小组每周进行两次一小时的会议，持续14周。研究结果是唾液皮质醇和感知学业压力。人体测量学和临床变量作为研究样本的特征被额外测量。感知学业压力通过结构化问卷进行评估。还进行了组内分析，以比较组内基线和干预后的结果。在基线时，干预组之间的人口学、临床和人体测量变量相似。干预后，冥想组和哈达瑜伽组在唾液皮质醇测量(时间0、15、30、45分钟，以及4项测量的平均值)和感知的学业压力方面没有发现差异。然而，组内分析显示，只有在哈他瑜伽中，皮质醇测量值显著增加，感知学业压力的规模有所改善。基于组内而非组间基线和干预后结果的比较，尽管伴随皮质醇水平显著增加，但哈他瑜伽减少了感知的学业压力。应该对更多的医学生样本进行进一步的试验，以对比我们的发现。

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引用次数: 0

Characteristics of the research literature on herbal medicines corresponding with herbal supplements yielding the highest total sales: A bibliometric analysis 草药研究文献的特点与草药补品产生最高的总销售额:文献计量学分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-05-01 DOI: 10.1016/j.aimed.2023.05.004

Jeremy Y. Ng , Swati Anant , Nandana D. Parakh

Background

Herbal medicines are frequently utilized for healthcare purposes. Due to their increased use globally, it is essential to understand the characteristics of the research literature published on this topic.

Methods

Search strategies were informed by the top-selling herbal supplements from the 2020 HerbalGram Market Report. The Natural Medicines database was used to identify and record the most common terms used to refer to the herbs listed in the market report. Searches were run on Scopus on August 02, 2021, and all results were exported on the same day to avoid discrepancies due to database updates. Bibliometric data were collected, including information on total number of publications, publications per year, number of authors and journals, open access status, document type, author affiliations, most highly published authors, institutional affiliations, funding sponsors, country of publication, and most highly cited publications. VOSViewer, a software tool, was used to construct and visualize bibliometric networks.

Results

A total of 42,385 articles published by 92,814 unique authors between 1827 and 2021 were obtained. An overall upward trend was observed in the number of publications, with the most widely researched herbal medicines being wheatgrass, turmeric, barley and garlic. The most productive countries were the United States (n = 6957) and China (n = 5426).

Conclusions

A continuous upward trend was identified with respect to the volume of research literature published about this subset of herbal medicines. Due to the projected increase of the use of these medicines, future research should examine and analyse the characteristics of emerging publications in this field.

背景草药经常用于医疗保健目的。由于它们在全球范围内的使用越来越多，因此了解有关该主题的研究文献的特征至关重要。方法搜索策略根据《2020年HerbalGram市场报告》中最畅销的草药补充剂。天然药物数据库用于识别和记录市场报告中列出的草药的最常见术语。搜索于2021年8月2日在Scopus上运行，所有结果都在同一天导出，以避免因数据库更新而出现差异。收集了文献计量数据，包括出版物总数、每年出版的出版物、作者和期刊数量、开放获取状态、文件类型、作者隶属关系、最受欢迎的作者、机构隶属关系、资助赞助商、出版国和最受欢迎出版物的信息。VOSViewer是一种软件工具，用于构建和可视化文献计量网络。结果1827年至2021年间，共获得92814位独立作者发表的42385篇文章。出版物的数量总体呈上升趋势，研究最广泛的草药是麦草、姜黄、大麦和大蒜。产量最高的国家是美国（n=6957）和中国（n=5426）。结论关于这一草药子集的研究文献发表量呈持续上升趋势。由于这些药物的使用预计会增加，未来的研究应该检查和分析该领域新兴出版物的特点。

{"title":"Characteristics of the research literature on herbal medicines corresponding with herbal supplements yielding the highest total sales: A bibliometric analysis","authors":"Jeremy Y. Ng , Swati Anant , Nandana D. Parakh","doi":"10.1016/j.aimed.2023.05.004","DOIUrl":"https://doi.org/10.1016/j.aimed.2023.05.004","url":null,"abstract":"<div><h3>Background</h3><p>Herbal medicines are frequently utilized for healthcare purposes. Due to their increased use globally, it is essential to understand the characteristics of the research literature published on this topic.</p></div><div><h3>Methods</h3><p>Search strategies were informed by the top-selling herbal supplements from the 2020 HerbalGram Market Report. The Natural Medicines database was used to identify and record the most common terms used to refer to the herbs listed in the market report. Searches were run on Scopus on August 02, 2021, and all results were exported on the same day to avoid discrepancies due to database updates. Bibliometric data were collected, including information on total number of publications, publications per year, number of authors and journals, open access status, document type, author affiliations, most highly published authors, institutional affiliations, funding sponsors, country of publication, and most highly cited publications. VOSViewer, a software tool, was used to construct and visualize bibliometric networks.</p></div><div><h3>Results</h3><p>A total of 42,385 articles published by 92,814 unique authors between 1827 and 2021 were obtained. An overall upward trend was observed in the number of publications, with the most widely researched herbal medicines being wheatgrass, turmeric, barley and garlic. The most productive countries were the United States (n = 6957) and China (n = 5426).</p></div><div><h3>Conclusions</h3><p>A continuous upward trend was identified with respect to the volume of research literature published about this subset of herbal medicines. Due to the projected increase of the use of these medicines, future research should examine and analyse the characteristics of emerging publications in this field.</p></div>","PeriodicalId":7343,"journal":{"name":"Advances in integrative medicine","volume":"10 2","pages":"Pages 64-79"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49710123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Australian reflexology workforce: A descriptive secondary-analysis from the PRACI practice-based research network 澳大利亚反射疗法劳动力:来自PRACI基于实践的研究网络的描述性二级分析

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-05-01 DOI: 10.1016/j.aimed.2023.05.002

Harriet Gibson , Amie Steel , Jon Adams

Objectives

This study provides the first detailed empirical examination of the reflexology profession and reflexology practice in Australia.

Design

Secondary analysis of the Practitioner Research And Collaboration Initiative (PRACI) online baseline workforce survey and practice-specific manual therapy follow-up survey.

Methods

The baseline survey collected data about participant sociodemographics, practitioner and professional characteristics, and clinical special interest areas. The Follow up survey provided more information about practice behaviours including participant use of diagnostic and therapeutic tools. Responses from both surveys were linked and the data were analysed for descriptive statistics. Bivariate analyses tested the association between practitioner characteristics across two subgroups: those participants with both a reflexology and massage qualification; and those with a reflexology qualification but no massage qualification.

Results

The baseline survey was completed by 128 reflexologists and 74 (57.8 %) of the baseline respondents completed the secondary practice-specific manual therapy survey. Substantially more females (86.7 %) completed the survey and the mean age of participants was 53.1 years (SD 10.4). A diverse range of clinical interest topics were disclosed. Most frequent were general health and wellbeing (81.3 %) and musculoskeletal complaints (78.1 %). Digestive disorders (68.0 %), women’s health complaints (66.4 %), endocrine conditions (64.8 %), pain (64.8 %) and allergies (60.2 %) were also commonly identified as clinical interest areas. Participants with a reflexology qualification only reported a lower hourly rate, less new clients per month and less days in clinical practice compared to other participants. They also reported discussing diet and nutrition, exercise prescription, nutritional supplements less often than other participants.

Conclusions

Reflexology is a manual therapy with a broad range of applications that ay support many health conditions. This study highlights the important priority areas for the Australian reflexology profession to ensure sustainability of their workforce into the future.

目的本研究首次对澳大利亚的反射疗法专业和反射疗法实践进行了详细的实证检验。设计对从业者研究与合作倡议（PRACI）在线基线劳动力调查和特定实践的手动治疗随访调查的二次分析。方法基线调查收集了参与者的社会人口统计学、从业者和专业特征以及临床特殊兴趣领域的数据。后续调查提供了更多关于实践行为的信息，包括参与者使用诊断和治疗工具的情况。将两项调查的答复联系起来，并对数据进行描述性统计分析。双变量分析测试了两个亚组的从业者特征之间的相关性：那些同时具有反射学和按摩资格的参与者；以及那些有反射按摩资格但没有按摩资格的人。结果128名反射科医生完成了基线调查，74名（57.8%）基线受访者完成了二次实践特定手法治疗调查。更多的女性（86.7%）完成了调查，参与者的平均年龄为53.1岁（SD 10.4）。披露了各种各样的临床兴趣主题。最常见的是一般健康和幸福感（81.3%）以及肌肉骨骼疾病（78.1%）。消化系统疾病（68.0%）、女性健康问题（66.4%）、内分泌疾病（64.8%）、疼痛（64.8%）和过敏（60.2%）也是临床关注的领域。与其他参与者相比，具有反射疗法资格的参与者只报告了较低的时薪、每月新客户数和临床实践天数。他们还报告说，与其他参与者相比，讨论饮食和营养、运动处方、营养补充剂的频率更低。结论屈光不正是一种应用广泛的手法疗法，可支持多种健康状况。这项研究强调了澳大利亚反射学专业的重要优先领域，以确保其劳动力在未来的可持续性。

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引用次数: 0

Successful pregnancy of a woman with PCOS after intervention with cyclic meditation – A case report 多囊卵巢综合征妇女经循环冥想干预后成功妊娠1例报告

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-05-01 DOI: 10.1016/j.aimed.2023.05.007

K.S. Lakshmi , M. Fathima Jebin , V. Venugopal , K. Maheshkumar

Background

Traditional Complementary and Integrative Medicine (TCIM) therapy usage for treating infertility has increased in the recent times. However the scientific documented evidence of mind-body interventions such as yoga and meditation on women with infertility still remains largely unexplored.

Methods

We report a case of 25-year-old female with PCOS and infertility, unable to conceive for the past two years. Regular practice of cyclic meditation was given four days a week for 4 months.

Results

The patient started practicing cyclic meditation for a duration of 35 min, four times a week for a period of four month, from the 5th day of menstruation. In the fourth month, she missed her periods on the expected day, after a delay of 20 days, she got menses which lasted for 5 days. After that, for the next month, again she missed her period and this time she was tested positive for pregnancy on the 35th day from the last menstrual period (LMP).

Conclusion

Regular practice of cyclic meditation could have a positive impact in women with secondary infertility due to PCOS. However, future studies with experimental study design is required to warrant our current findings.

背景近年来，传统中西医结合治疗不孕不育的应用有所增加。然而，对不孕妇女进行瑜伽和冥想等身心干预的科学证据在很大程度上仍未得到探索。方法我们报告一例25岁女性多囊卵巢综合征和不孕，在过去两年内无法怀孕。在4个月的时间里，每周四天进行定期的循环冥想练习。结果患者从月经来潮第5天开始，每周4次，持续35分钟，为期4个月。第四个月，她错过了预期日期的月经，在推迟了20天后，她月经来潮了5天。之后，在接下来的一个月里，她再次错过了月经，这次她在最后一次月经后的第35天（LMP）被检测出怀孕呈阳性。然而，未来的研究需要实验研究设计来保证我们目前的发现。

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引用次数: 1

Predictors of herbal medicine use in Ashanti Region of Ghana 加纳阿散蒂地区草药使用的预测因素

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-05-01 DOI: 10.1016/j.aimed.2023.05.005

James Afriyie , Akwasi Kumi-Kyereme

Objective

To determine the predictors of herbal medicine use among adults in Ashanti Region of Ghana.

Method

A cross sectional study design was employed to obtain data from 910 adults using a questionnaire. Multivariate logistic regression analysis was conducted to determine the predictors of herbal medicine use.

Results

Majority of the respondents (73.7%) had used herbal medicine within 1 year prior to the survey. Living in a district (adjusted odds ratio [AOR] = 2893, CI: 1.646 −5076, p < .001) and being older than 20 years were the factors that predicted use of herbal medicine. The other predictors included having the opinion that herbal medicines work very well (AOR= 6.072, CI: 3.237 – 11.386, p < .001) or work somehow (AOR= 3.525, CI: 1.885 – 6.591, p < .001), and having the belief that one could definitely (AOR= 5.084, CI: 2.952 – 8.754, p < .001) or maybe (AOR= 2.034, CI: 1.186 – 3.487, p = .01) use herbal medicine with ease.

Conclusions

The study observed a high prevalence of herbal medicine use in the Ashanti region of Ghana particularly among those living in the districts and those older than 20 years of age. Predictors of herbal medicine use include positive perception of efficacy and ease of use. This highlights a need for public engagement via all forms of media on the possible implications of the safety and efficacy of herbal medicines.

目的确定加纳阿散蒂地区成年人中草药使用的预测因素。方法采用横断面研究设计，使用问卷从910名成年人中获得数据。进行多变量逻辑回归分析，以确定草药使用的预测因素。结果大多数受访者（73.7%）在调查前1年内使用过中草药。居住在一个地区（调整后的比值比[AOR]=2893，CI:1.646−5076，p<；.001）和年龄超过20岁是预测草药使用的因素。其他预测因素包括认为草药效果很好（AOR=6.072，CI:3.237-11.386，p<；.001）或以某种方式起作用（AOR=3.525，CI:1.885-6.591，p&lgt；.001），以及相信人们肯定可以（AOR=5.084，CI:2.952-8.754，p&llt；.001）或者可能（AOR=2.034，CI:1.186-3.487，p=.01）轻松使用草药。结论该研究观察到，加纳阿散蒂地区的草药使用率很高，尤其是在居住在该地区的人和20岁以上的人中。草药使用的预测因素包括对疗效和易用性的积极感知。这突出表明，需要通过各种形式的媒体让公众参与草药的安全性和有效性的可能影响。

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引用次数: 0

Efficacy of a prebiotic formulation for treatment of functional constipation and associated gastrointestinal symptoms in adults: A randomised controlled trial 一种益生元制剂治疗成人功能性便秘及相关胃肠道症状的疗效:一项随机对照试验

IF 1.7 Q2 Medicine

Advances in integrative medicine

Pub Date : 2023-05-01 DOI: 10.1016/j.aimed.2023.05.001

Elizabeth Steels , Rene Erhardt , Joanna E. Harnett , Vanessa Vigar , Kathryn J. Steadman

Objectives

Functional constipation is the result of a complex interplay between the gastrointestinal tract, the gut microbiome, the nervous system, along with diet and lifestyle factors. This study aimed to evaluate the efficacy of a prebiotic formulation containing plant-based extracts rich in dietary fibre and polyphenols in the management of functional constipation and associated gastrointestinal symptoms.

Design

This 3-week randomised controlled study assessed the effect of a prebiotic formulation (6 g powder taken in water twice daily), by comparison with a capsule designed to have minimal effect on gastrointestinal function, on indicators of bowel health in healthy adults with low fibre intake and meeting the Rome IV criteria for functional constipation.

Methods

Participants were informed that they may receive one of two products, either a powder or a capsule, both of which contained prebiotics. The primary outcome was change in frequency of complete spontaneous bowel movements. Secondary outcomes assessed were gastrointestinal symptoms, quality of life and mood using the PAC-SYM, PAC-QoL, and DASS-21. Safety and tolerability were also assessed.

Results

There was a significant improvement in bowel movements (p < 0.001) and improved stool consistency (p < 0.01) in participants taking the prebiotic powder formulation compared to those taking the capsule. Accompanying this was a significant reduction in overall gastrointestinal symptoms (p < 0.001) including abdominal (p < 0.001), rectal (p = 0.004) and stool (p = 0.002) symptoms, and a significant improvement in quality of life (p 0.001). There was a significant reduction in mean score for depression, anxiety, and stress for participants in both groups, which indicated a significant improvement in mood during the study that was unrelated to bowel function.

Conclusions

The results showed that the prebiotic powder formulation taken twice per day for 21 days was effective in reducing clinical symptoms of functional constipation in individuals reporting a low fibre intake.

目的功能性便秘是胃肠道、肠道微生物组、神经系统以及饮食和生活方式因素之间复杂相互作用的结果。本研究旨在评估含有富含膳食纤维和多酚的植物提取物的益生元配方在治疗功能性便秘和相关胃肠道症状方面的疗效。设计这项为期3周的随机对照研究通过与设计对胃肠功能影响最小的胶囊进行比较，评估了益生元配方（6克粉末，每天两次）对低纤维摄入且符合罗马IV功能性便秘标准的健康成年人肠道健康指标的影响。方法参与者被告知，他们可能会收到两种产品中的一种，粉末或胶囊，这两种产品都含有益生元。主要结果是完全自发排便频率的变化。使用PAC-SYM、PAC-QoL和DAS-21评估的次要结果是胃肠道症状、生活质量和情绪。还评估了安全性和耐受性。结果与服用胶囊的参与者相比，服用益生元粉末制剂的参与者排便次数显著改善（p＜0.001），大便稠度显著改善（p＜0.01）。与此同时，包括腹部（p＜0.001）、直肠（p＝0.004）和粪便（p＝0.002）症状在内的整体胃肠道症状（p＜001）显著减少，生活质量显著改善（p＝0.001）。两组参与者的抑郁、焦虑和压力平均分均显着降低，这表明在研究期间情绪显著改善，这与肠功能无关。结论研究结果表明，益生元粉末制剂每天服用两次，持续21天，可有效减轻纤维摄入量低的患者功能性便秘的临床症状。

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