Journal of lifestyle medicine最新文献

Background: The intervention in the Lifestyle Medicine Clinic from La Carlota Hospital gives an opportunity to assess the clinical effect of a healthy lifestyle in an inpatient setting with emphasis in a plant-based diet, supervised daily exercise, sleep hygiene, psychological and optional spiritual therapies. This work evaluated the effect of short-term therapy on biometrics and blood profiles' risk factors for non-communicable diseases (NCDs).

Methods: Twenty-five patients were enrolled in the intervention, 12 for the 10-day intervention and 13 for the 21-day intervention.

Results: The intervention improved most of the NCDs risk factors for the 10-day intervention weight decreased by -4.3% (p < .001), BMI -4.1% (p < .001), SBP -16.3% (p = .002), DBP -11.8% (p = .004), fasting glucose -31.3% (p = .041), total cholesterol -12.8% (p < .001), LDL -13.9 (p = .017), triglycerides and HDL lack statistical significance, however, there was a reduction of -7.7% and -9% respectively. For the 21-day intervention weight decreased by -8.3% (p = .016), SBP -11.2% (p = .005), DBP -11.4% (p = .022), triglycerides -39.5% (p = .034), total cholesterol -23.6% (p < .000), HDL -14.7% (p = .038), LDL -27.3% p < .000), BMI and fasting glucose presented a -15.2% and -21.2% reduction respectively without statistical significance.

Conclusion: The present study confirms that short-term lifestyle interventions effectively reduce the risk factors associated with NCD's.

Background: Scarce information is available on circadian body temperature fluctuation in healthy healthcare workers.

Methods: Forehead temperature was measured with an infrared thermometer in 33 ostensibly healthy laboratory professionals (mean age, 43 ± 13 years; 76% females) throughout a regular working shift, from 800 AM to 300 PM, at 1-hour intervals.

Results: A significant difference was found at different times of the day by 1-way analysis of variance (F statistics, 13.79; p < 0.001). The lowest mean forehead temperature was 36.2 ± 0.3℃, recorded at 100 PM, whilst the highest was 36.7 ± 0.3℃, at 900 AM. The mean difference between forehead temperature at acrophase and nadir was 0.5℃ (95% CI, 0.3-0.6℃; p < 0.001). The forehead temperature measured between 900-1200 AM was also significantly higher than that measured between 100-300 PM (0.3℃; 95% CI, 0.2-0.4℃; p < 0.001). The mean intra-individual variation of forehead temperature was higher but not significantly different in men (1.0 ± 0.2%) compared to women (0.8 ± 0.3%; p = 0.112).

Conclusion: Fever screening protocols for purposes of coronavirus disease 2019 (COVID-19) and other infectious diseases monitoring should consider normal daily fluctuations in forehead temperature.

Background: Rectus abdominis is the main core muscle. Weakness or any alteration in it may increase the pressure over the lower back, in obese women diastasis of rectus abdominis muscle found to be very common condition. Therefore, there may be a correlation between diastasis of rectus abdominis muscle and low back pain in obese women that needs to be explored, as there is no literature available.

Methods: In this study, 72 female subjects with Body Mass Index <30 kg/m² were recruited by snowball sampling method. Demographic (name, age) and anthropometric characteristics (height, weight and body mass index) were recorded. The separation in the rectus abdominis muscle was assessed with vernier calliper.

Results: Total subjects were included in the study; all the subjects were Female without any recent abdominal surgical history. The subjects included in the study with age of 30 years to 55 years old with body mass index of the included females must be (30-30.9) kg/m² i.e. women must come under obese category. Diastasis of rectus abdominis muscle was another variable used that must be present in each women. Low back pain was also used as the variable that may be present or may not be present in the women with diastasis of rectus abdominis muscle. The collected data were analysed by the appropriate statistical analysis tools. The p-value was found more than 0.05 (the alpha level set was less than 0.05) which is non-significant.

Conclusion: The study concluded a non-significant correlation between the diastasis of rectus abdominis muscle and low back pain in obese women. The present study concludes that it is not necessary that all obese women with low back pain always propose to have diastasis of rectus abdominis muscle.

Background: Mitochondrial-derived peptides (MDPs) such as MOTS-c and humanin have been studied for their cytoprotective functions. In mice, humanin-encoding Mtrnr2 is a mitochondrial pseudogene, and the humanin-like peptide is encoded by the nuclear Gm20594 gene. However, endogenous tissue-specific expression profiles of Gm20594 have not yet been identified.

Methods: Mtrnr1 and Gm20594 expression was profiled via reverse transcription using only oligo(dT) primers from tissues of C57BL6/J mice. To analyze altered expression upon mitochondrial biogenesis, C2C12 myocytes and brown adipocytes were differentiated. Mitochondrial DNA copy numbers were quantified for normalization.

Results: Both Mtrnr1 and Gm20594 were highly expressed in brown adipose tissue. When normalized against mitochondrial content, Mtrnr1 was identified as being highly expressed in the duodenum, followed by the jejunum. In models of mitochondrial biogenesis, both Mtrnr1 and Gm20594 were upregulated during myocyte and brown adipocyte differentiation. Increased Mtrnr1 expression during brown adipocyte differentiation remained significant after normalization against mitochondrial DNA copy number, whereas myocyte differentiation exhibited biphasic upregulation and downregulation in early and late phases, respectively.

Conclusion: Nuclear-encoded Gm20594 showed similar expression patterns of mitochondrial-encoded Mtrnr1. Brown adipose tissue presented the highest basal expression levels of Gm20594 and Mtrnr1. When normalized against mitochondrial DNA copy number, gut tissues exhibited the highest expression of Mtrnr1. Upregulation of Mtrnr1 during mitochondrial biogenesis is independent of mitochondrial content.

Cancer incidences are rising globally. Therefore, in order to prevent and treat cancer, understanding cancer pathology is crucial. Tumors reprogram their metabolic phenotype to meet their needs for bioenergy, biosynthesis, and redox control. Alteration of the metabolic pathway has been proposed as the hallmark of cancer and explains the distinction between normal and cancer cells concerning nutrient utilization. Changes in the metabolism of nutrients such as glucose, amino acid, and fatty acid are associated with cancer risk. Luckily, this can be controlled with lifestyle modifications. Improvements in lifestyle behaviors to reduce cancer risks include a healthy diet, calorie restriction, and regular physical activity. This review begins with the understandings of metabolic reprogramming in cancer. Then, there will be evidence on the correlation between lifestyle factors and altered nutrient metabolism suggesting an application of lifestyle intervention for cancer risk reduction.

Background: The Community Coalition Action Theory (CCAT) is a form of theories for the change across organizations. A community coalition is a structured arrangement where all members can work together on a common goal and objective. This article aimed to present how to use of CCAT framework to design interventions for increase seat belt in the bus.

Methods: The current article focuses on applications of the CCAT to provide framework for the development of activities and interventions related to bus seat belt usage.

Results: The CCAT have fourteen constructs include stages of development, community context, lead agency or convening group, coalition membership, processes, leadership and staffing, structures, pooled membership and external resources, member engagement, collaborative synergy, assessment and planning, implementation of strategies, community change outcomes, health/social outcomes and community capacity.

Conclusion: CCAT is one of the best practices that can be achieved through joint activities of multiple organizations that lead to improved health behaviors.

In this report, we describe a case of a 37-year old man who presented with a history of total cholesterol > 14 mmol/L and triglyceride levels > 40 mmol/L. The patient was initially thought to have familial hypercholesterolemia due to his elevated total cholesterol, by his family physician. He was prescribed evolucumab, a proprotein convertase subtilisin/ kexin type 9 inhibitor drug which has shown efficacy for lowering low-density lipoprotein-cholesterol levels, to reduce his high total cholesterol. However, in this patient, the elevated total cholesterol was likely due to hypertriglyceridemia, rather than increased low-density lipoprotein-cholesterol levels. Through this case we provide an approach for the clinical management of patients with elevated total cholesterol with underlying triglycerides ≥ 10 mmol/L. The primary intervention for management of triglycerides ≥ 10 mmol/L involves lifestyle modifications including, changes in diet, exercise, reduction in body mass index, and abstinence from alcohol consumption. Secondary intervention involves management through pharmacotherapy with fibrates and statins. Creating a plan of action with the patient, incorporating lifestyle modifications alone, the patient was able to reduce the triglycerides from an average of 44.94 mmol/L to 3.28 mmol/L.

Background: Combining the results of objective and subjective assessments of physical activity (PA) can provide a more complete assessment of PA patterns in medical students. This study aimed to determine the relationships between objective and subjective measured PA and its relation with socio-demographic characteristics among different stages of medical training.

Methods: This cross-sectional study was conducted on 186 students of four stages of medical training. The International Physical Activity Questionnaire Short-Form (IPAQ-SF) and pedometer were used.

Results: There were significant differences in total PA in terms of gender, weight, and serious illness. Differences between four stages of medical training in total (p = 0.002), vigorous (p < 0.001), and moderate PA (0.026) based on IPAQ-SF as well as pedometer-counted steps in Tuesday (p = 0.002) and Wednesday (p = 0.006) were significant. The results demonstrated a positive significant relationship between total PA based on IPAQ-SF and pedometer-determined steps in four days of the week.

Conclusion: There were positive low correlations between PA based on IPAQ-SF and pedometer among medical students. The PA of medical students at different years of medical training was different based on both IPAQ-SF and pedometer, which shows the need to pay attention to the special needs of students in terms of PA at each stage.

Background: Diabetes, hypertension, and obesity are vastly prevalent in the United States. Lifestyle modification programs can aid in controlling chronic disease. The aim of the study was to evaluate the health outcomes of the Complete Health Improvement Program (CHIP) concerning blood glucose, blood pressure, and weight. CHIP is a lifestyle medicine education program involving diet modification and increased physical activity.

Methods: A quantitative, summative program evaluation was performed to measure the outcomes of CHIP. Pre and post data sets were collected on 73 individuals who completed the 12-week CHIP program. Pre and post program blood glucose levels, blood pressure readings, and weight measurements were analyzed using a paired t-test with a 95% confidence level. Analysis determined influence of the intervention on the biomarkers.

Results: The post-intervention group means showed decreases in blood glucose, blood pressure, and weight. Statistical analysis revealed significant decreases in blood glucose (p = 0.008) and weight (p = 0.000). Blood pressure readings did not have statistically significant decreases (p = 0.403); however, the pre-intervention blood pressure readings were in the normotensive range.

Conclusion: Results indicated that the Complete Health Improvement Program decreased participants' blood glucose levels, blood pressure readings, and weight measurements. Statistically significant decreases in blood glucose and weight suggest enhanced control of diabetes and obesity through utilization of CHIP.

Background: Smoking cigarettes which progressively impairs the lung functions is a leading risk factor for early death and disability worldwide. Alternate use of the tobacco products along with some exercise practicing behaviour help to prevent the impairment of lung function because most smokers fail to cease smoking. The objective of this research was to find out the effectiveness of the balloon blowing exercise among the young adult smokers using the peak expiratory flow meter.

Methods: A quasi- experimental study in which 100 male participants were included according to inclusion and exclusion criteria. Pre-test and Post-test was taken using Peak expiratory flow meter, after intervention is provided.

Results: The mean appraise of the Group A pre-test was 287.1 and the post-test was 283.2, and the mean appraise of the Group B pre-test was 279.7 and the post-test was 367.2. The significant appraise was .581 for Group A and .000 for the Group B since the p < 0.05. The study shows the significant result as the p appraise is less than 0.05.

Conclusion: This study concludes that there was a significant increase in the peak expiratory flow rate in the post test of Group B.