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Concentrations and probable health risks of potentially toxic metals (Pb, Cd and Cr) in some Nigerian lipstick products 尼日利亚部分口红产品中潜在有毒金属(铅、镉和铬)的浓度和可能的健康风险
Pub Date : 2024-04-24 DOI: 10.1016/j.jtemin.2024.100142
Ogundele L. Tunde , Ayeku P. Oluwagbemiga , Oladejo O. Felix

Background

Lipstick is one of the widely used cosmetic items that are produced from both natural and processed materials and they are one of the sources of metals and metalloids released among the users. This study measured concentrations of Pb, Cd and Cr in some brands of Nigerian lipstick products and assessed their probable health risks to the users.

Methods

A total of twenty (L1 - L20) brands of lipstick products were purchased from the central cosmetic stores and the samples were prepared, digested and concentrations of Pb, Cd and Cr were determined using Atomic Absorption Spectrometry (AAS). The probable health risk was assessed via average daily dose (ADD) by ingestion route, hazard quotient (HQ), hazard index (HI), cancer risks (CR), and relative intake index (RII).

Results

The ranges of concentrations of Pb, Cd and Cr were 5.6 - 25.1, 2.5 - 21.5 and 5.0 - 61.7 μg g−1, respectively. The ranges of ADD values of Pb, Cr and Cd were 1.2 × 103 - 5.7 × 103; 1.3 × 103 - 5.7 × 103 and 5.1 × 103 - 1.4 × 103 µg day1, respectively. Among the samples Cr had HQ values 1.3 to 9.6. The HQ values of Cd for L2, L6, L12 and L14 ranges between 1.1 and 1.5. Then HQ values of Pb for L1 -L20 were 1.0 - 4.1. The HI values of Pb, Cr and Cd in each lipstick brands range from 2.8 to 12.5, indicating a non-carcinogenic health risk. The CR values for Cr and Cd are from 6.6 × 10−4 to 6.9 × 10−4 and from 2.0 × 10−2 to 2.5 × 10−2, respectively and they were within the acceptable limit value of 1.0 × 10−4. The RII of Pb, Cd and Cr were 4.50 - 20.1, 2.0 – 19.2 and 1.9 – 23.0 %, respectively.

Conclusion

All the health indices indicated non-carcinogenic health risks. The continuous exposure and unintentional ingestion of such lipstick products can pose high risks to the users due to bioaccumulation of Pb, Cd and Cr which may lead to negative health conditions.

背景口红是广泛使用的化妆品之一,由天然材料和加工材料制成,是使用者释放金属和类金属的来源之一。本研究测量了尼日利亚一些品牌口红产品中的铅、镉和铬的浓度,并评估了它们对使用者可能造成的健康风险。方法从中央化妆品商店购买了二十(L1 - L20)个品牌的口红产品,制备、消化样品并使用原子吸收光谱法(AAS)测定铅、镉和铬的浓度。结果 铅、镉和铬的浓度范围分别为 5.6 - 25.1、2.5 - 21.5 和 5.0 - 61.7 μg g-1。铅、铬和镉的 ADD 值范围分别为 1.2 × 10-3 - 5.7 × 10-3;1.3 × 10-3 - 5.7 × 10-3 和 5.1 × 10-3 - 1.4 × 10-3 µg day-1。在这些样本中,铬的 HQ 值为 1.3 至 9.6。L2、L6、L12 和 L14 样品中镉的 HQ 值介于 1.1 和 1.5 之间。L1 - L20 中铅的 HQ 值为 1.0 - 4.1。各品牌口红中铅、铬和镉的 HI 值介于 2.8 至 12.5 之间,表明不会对健康造成危害。铬和镉的 CR 值分别为 6.6 × 10-4 至 6.9 × 10-4 和 2.0 × 10-2 至 2.5 × 10-2,均在 1.0 × 10-4 的可接受限值范围内。铅、镉和铬的 RII 分别为 4.50 - 20.1%、2.0 - 19.2%和 1.9 - 23.0%。由于铅、镉和铬的生物累积作用,持续接触和无意摄入此类口红产品会给使用者带来高风险,可能导致不良健康状况。
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引用次数: 0
Heavy metals and radionuclides in Islamabad's industrial area: A comprehensive analysis of soil and water pollution, source apportionment and health effects using statistical and geospatial tools 伊斯兰堡工业区的重金属和放射性核素:利用统计和地理空间工具全面分析土壤和水污染、来源分配和健康影响
Pub Date : 2024-04-21 DOI: 10.1016/j.jtemin.2024.100127
Mavia Anjum , Naila Siddique , Hannan Younis , Yasir Faiz , Munib Ahmed Shafique , Anjum Mahnoor , Ayesha Sajid , Muhammad Altaf

Introduction

Heavy metal pollution in industrial areas around the world is a significant problem that is worsening day by day. Heavy and toxic metals are detrimental to human health and ecology in a region. Hence, determining their level and potential is critical to form effective pollution control strategies for reducing the risks associated with them.

Study area

Islamabad is the capital city of Pakistan with a dedicated industrial zone.

Purpose

This study evaluated the heavy metal pollution levels in the soil and water of Islamabad's industrial area and radionuclides activity in the soil using statistical, geospatial tools as well as their subsequent health and ecological hazards.

Materials and methods

Elemental analysis in this study was performed using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES). The radionuclides activity in the soil was quantified using High Purity Germanium Detector (HPGe).

Results

The soil of Islamabad's industrial area is highly polluted with heavy and toxic metals. The risk posed by heavy metals to the eco-system was calculated using Ecological risk factor and was found to be above recommended level. Principal component analysis (PCA), Pearson's correlation and inverse distance weighting interpolation (IDW) revealed that the soil near the steel mills, landfill and marble processing plants is extremely polluted with heavy metals. Health hazards from heavy metal exposure through ingestion, inhalation, and dermal contact were also calculated. Cr posed a carcinogenic risk to children via the three exposure pathways with the value being 4 × 10−4. Natural radioactivity levels for Ra-226, Th-232 and K-40 were found to be 25.96±12.50, 15.84±2.59, 469.48±52.38 Bqkg−1, respectively. Elemental analysis of water samples coupled with geospatial analysis showed that water samples collected near the industrial complexes have elevated levels of Sb. The water quality for irrigation was assessed and the water from Islamabad's industrial area was found to be suitable for irrigation.

Conclusion

In conclusion, the soil of Islamabad's industrial area is highly polluted with heavy metals and has lower levels of natural radioactivity. The water near the industries also has elevated levels of some heavy metals.

导言世界各地工业区的重金属污染是一个严重问题,而且日益恶化。重金属和有毒金属对人类健康和地区生态环境有害。本研究使用统计和地理空间工具评估了伊斯兰堡工业区土壤和水体中的重金属污染水平和土壤中的放射性核素活度,以及其对健康和生态的危害。结果伊斯兰堡工业区的土壤受到重金属和有毒金属的严重污染。使用生态风险因子计算了重金属对生态系统造成的风险,结果发现重金属含量高于建议水平。主成分分析(PCA)、皮尔逊相关性和反距离加权插值(IDW)显示,钢铁厂、垃圾填埋场和大理石加工厂附近的土壤受到严重的重金属污染。此外,还计算了通过摄入、吸入和皮肤接触重金属对健康造成的危害。铬通过三种接触途径对儿童造成的致癌风险值为 4 × 10-4。镭-226、钍-232 和 K-40 的天然放射性水平分别为 25.96±12.50、15.84±2.59 和 469.48±52.38 Bqkg-1。水样的元素分析和地理空间分析表明,在工业园区附近采集的水样中锑含量较高。对灌溉用水的水质进行了评估,发现伊斯兰堡工业区的水适合灌溉。工业区附近的水体中一些重金属的含量也很高。
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引用次数: 0
Supplementation of critical micro-nutrients in peri‑parturient dairy buffaloes improves lactation performance 为围产期奶水牛补充关键微量营养素可提高泌乳性能
Pub Date : 2024-04-19 DOI: 10.1016/j.jtemin.2024.100136
Vikas Jyani , Vishal Mudgal , Meenakshi Gupta , Anurag Bharadwaj

Background

The peri‑parturient period is the most vital period of a dairy animal's life and affects its future performance. Dairy animals get exposed to severe metabolic stress during the peri‑parturient period and their stress tolerance capacity during the period remains a key factor to harvest optimum production from these animals without getting exposed to any of peri‑parturient disorders. The study aimed to evaluate the effect of weekly critical micro-nutrient (CMN) supplementation during the periparturient period on the lactation performance of Murrah buffaloes.

Methods

Weekly CMN (vitamins E, A, and niacin with minerals Co, Cr, Cu, Se, and Zn) supplementation during the periparturient period (56 days prepartum, till 56 days post-partum) was performed on twenty-two healthy Murrah buffaloes during their advanced stage of gestation following dividing them into two groups of 11 buffaloes in each group, representing control and supplemented (Treatment) groups. Buffaloes were selected and sustained on recommended practices of feeding as per nutrient requirements, except the inclusion of CMN supplement once a week in the treatment group's buffaloes after proper mixing with common concentrate mixture being fed to buffaloes. Weekly milk production recording was carried out with analysis of milk quality parameters, for an initial 10 weeks of the lactation.

Results

The treatment helped in improving the milk production record of buffaloes; total milk yield by 18 % and fat-corrected milk by 30 % (P < 0.05). It leads to qualitative improvement as well (percentage of milk fat and protein, P < 0.05).

Conclusion

It may be concluded that weekly supplementation of critical micronutrients during the periparturient period helps improve buffalo milk production performance.

背景围产期是乳牛一生中最关键的时期,影响着其未来的生产性能。乳牛在围产期会面临严重的新陈代谢应激,其在这一时期的应激耐受能力是乳牛获得最佳产量而不会出现任何围产期疾病的关键因素。本研究旨在评估围产期每周补充关键微量营养素(CMN)对伊拉水牛泌乳性能的影响。方法在围产期(产前 56 天至产后 56 天)每周补充 CMN(维生素 E、A 和烟酸以及矿物质 Co、Cr、Cu、Se 和 Zn),对象是 22 头处于妊娠后期的健康穆拉水牛,将其分为两组,每组 11 头,分别代表对照组和补充(治疗)组。根据营养需求选择水牛并按照推荐的喂养方法喂养,但在与普通精料混合物适当混合后,在治疗组水牛中每周添加一次 CMN 补充剂。在最初 10 周的泌乳期内,每周记录产奶量并分析牛奶质量参数。结果治疗有助于提高水牛的产奶量;总产奶量提高了 18%,脂肪校正奶提高了 30%(P < 0.05)。结论在围产期每周补充关键微量营养素有助于提高水牛的产奶性能。
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引用次数: 0
Biofortification of scent leaf (Ocimum gratissimum L.) with selenium enhances antiinflammatory cytokines and humoral response in Wistar rats 用硒对香叶(Ocimum gratissimum L.)进行生物强化可增强 Wistar 大鼠体内的抗炎细胞因子和体液反应
Pub Date : 2024-04-17 DOI: 10.1016/j.jtemin.2024.100128
IniOluwa AyoOluwa Akindoyeni , Idowu Sunday Oyeleye , Omodesola Oluwafisayo Ogunruku , Ganiyu Oboh

Background

Dietary selenium (Se) has been shown to influence immunity in both humans and rats. It exerts its health effects via incorporation into selenoproteins involved in both innate and adaptive immunity. It is also involved in the synthesis and activity of the antioxidant enzyme glutathione peroxidase. This study sought to investigate the effect of Se biofortified scent leaves (Ocimum gratissimum L.) on selected immunomodulatory and inflammatory markers in wistar rats.

Methodology

Scent leaf plant was cultivated on Se fortified (0–0.1 %) soil. Upon maturity, the leaves were harvested and the Se and phenolic contents, as well as in vitro antioxidant properties were determined. Subsequently, dietary inclusions of the Se biofortified scent leaves were fed to rats. The experimental rats consist of control group fed basal diet, rats fed 2.5 % and 5.0 % dietary inclusions of unfortified scent leaves and rats fed 2.5 % and 5.0 % dietary inclusions of 0.05 % Se-fortified scent leaves. This was carried out for 30 days, after which selected immunomodulatory and inflammatory markers, as well as glutathione peroxidase activity (GPx) were quantified in the serum.

Results

The vegetables bioaccumulated Se in the leaves up to 0.93 ± 0.05 mg/100 g d.w. The Se biofortified scent leaves exhibited significantly higher in vitro antioxidant properties, total phenol and flavonoid contents quantitatively and qualitatively. In experimental rats, it was observed that the 0.05 % Se biofortified scent leaves based-diets significantly increased the levels of the anti- inflammatory cytokines (IL-4 and IL-10). Furthermore, there were significant increase in serum Immunoglobulins G and M in rats fed dietary inclusions of the Se biofortified leaves.

Conclusion

The study suggests that Se biofortification at optimum level of 0.05 % increased phenolic content in scent leaf and improved rat´s anti-inflammatory and antibodies, hence making the vegetables candidate functional food with potential anti-inflammatory and immune boosting properties.

背景膳食硒(Se)已被证明可影响人类和大鼠的免疫力。硒通过与参与先天性免疫和适应性免疫的硒蛋白结合而发挥其保健作用。它还参与抗氧化酶谷胱甘肽过氧化物酶的合成和活性。本研究试图探讨生物强化硒的香叶(Ocimum gratissimum L.)对wistar大鼠体内某些免疫调节和炎症指标的影响。成熟后采收叶片,测定其中的硒和酚含量以及体外抗氧化特性。随后,用含 Se 生物强化香叶的食物喂养大鼠。实验大鼠包括喂食基础食物的对照组、喂食 2.5 % 和 5.0 % 未强化香叶膳食内含物的大鼠,以及喂食 2.5 % 和 5.0 % 含有 0.05 % Se 强化香叶膳食内含物的大鼠。结果蔬菜叶片中硒的生物累积量达到 0.93 ± 0.05 mg/100 g d.w.,硒生物强化香叶的体外抗氧化性、总酚和类黄酮的定量和定性含量均显著提高。在实验大鼠身上观察到,基于 0.05 % Se 生物强化香叶的膳食明显提高了抗炎细胞因子(IL-4 和 IL-10)的水平。此外,用含 Se 生物强化叶片的膳食喂养大鼠,其血清免疫球蛋白 G 和 M 也有明显增加。
{"title":"Biofortification of scent leaf (Ocimum gratissimum L.) with selenium enhances antiinflammatory cytokines and humoral response in Wistar rats","authors":"IniOluwa AyoOluwa Akindoyeni ,&nbsp;Idowu Sunday Oyeleye ,&nbsp;Omodesola Oluwafisayo Ogunruku ,&nbsp;Ganiyu Oboh","doi":"10.1016/j.jtemin.2024.100128","DOIUrl":"https://doi.org/10.1016/j.jtemin.2024.100128","url":null,"abstract":"<div><h3>Background</h3><p>Dietary selenium (Se) has been shown to influence immunity in both humans and rats. It exerts its health effects via incorporation into selenoproteins involved in both innate and adaptive immunity. It is also involved in the synthesis and activity of the antioxidant enzyme glutathione peroxidase. This study sought to investigate the effect of Se biofortified scent leaves (<em>Ocimum gratissimum</em> L.<em>)</em> on selected immunomodulatory and inflammatory markers in wistar rats.</p></div><div><h3>Methodology</h3><p>Scent leaf plant was cultivated on Se fortified (0–0.1 %) soil. Upon maturity, the leaves were harvested and the Se and phenolic contents, as well as in vitro antioxidant properties were determined. Subsequently, dietary inclusions of the Se biofortified scent leaves were fed to rats. The experimental rats consist of control group fed basal diet, rats fed 2.5 % and 5.0 % dietary inclusions of unfortified scent leaves and rats fed 2.5 % and 5.0 % dietary inclusions of 0.05 % Se-fortified scent leaves. This was carried out for 30 days, after which selected immunomodulatory and inflammatory markers, as well as glutathione peroxidase activity (GPx) were quantified in the serum.</p></div><div><h3>Results</h3><p>The vegetables bioaccumulated Se in the leaves up to 0.93 ± 0.05 mg/100 g d.w. The Se biofortified scent leaves exhibited significantly higher in vitro antioxidant properties, total phenol and flavonoid contents quantitatively and qualitatively. In experimental rats, it was observed that the 0.05 % Se biofortified scent leaves based-diets significantly increased the levels of the anti- inflammatory cytokines (IL-4 and IL-10). Furthermore, there were significant increase in serum Immunoglobulins G and M in rats fed dietary inclusions of the Se biofortified leaves.</p></div><div><h3>Conclusion</h3><p>The study suggests that Se biofortification at optimum level of 0.05 % increased phenolic content in scent leaf and improved rat´s anti-inflammatory and antibodies, hence making the vegetables candidate functional food with potential anti-inflammatory and immune boosting properties.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"8 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000132/pdfft?md5=c20d62e55f4ac7a9339a8e08d9770728&pid=1-s2.0-S2773050624000132-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140638380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heavy metal levels in camel milk and health risk assessment: A global systematic review 骆驼奶中的重金属含量与健康风险评估:全球系统性审查
Pub Date : 2024-04-16 DOI: 10.1016/j.jtemin.2024.100131
Mohamed Amine Kerdoun , Rachid Djafer

Introduction

This systematic review investigates the potential toxicity of metals and metalloids, including lead (Pb), mercury (Hg), cadmium (Cd), and nickel (Ni), in raw camel milk, with a focus on health risk assessment for human consumption through the calculation of Target Hazard Quotient (THQ) and Carcinogenesis Risk (CR).

Methods

From 927 initial articles, we analyzed 20 original articles, comprising 787 samples published between 2000 and 2024.

Results

Pb levels ranged from nondetectable to 1.560 mg.kg−1, while Cd levels ranged from 0.0008 to 0.800 mg.kg−1. Egypt and Saudi Arabia reported the highest levels of Pb, Ni, and Cd. Pb concentrations in milk exceeded the Codex Alimentarius recommended limit (0.020 mg.kg−1) in 10 out of 18 studies. Overall, Pb and Cd exposure through milk consumption appeared safe for humans, although THQ values exceeded 1 in two Pb studies out of 18 and in one Cd study out of 16.

Conclusion

This study contributes to establishing an international database on toxic metal levels in camel milk, informing strategies for managing metal-related risks in milk consumption.

导言本系统综述调查了生骆驼奶中金属和类金属的潜在毒性,包括铅(Pb)、汞(Hg)、镉(Cd)和镍(Ni),重点是通过计算目标危害商数(THQ)和致癌风险(CR)评估人类食用的健康风险。结果 铅的含量从检测不到到 1.560 毫克/千克不等,镉的含量从 0.0008 到 0.800 毫克/千克不等。埃及和沙特阿拉伯的铅、镍和镉含量最高。在 18 项研究中,有 10 项研究发现牛奶中的铅浓度超过了食品法典建议的限值(0.020 毫克/千克-1)。总体而言,人类通过饮用牛奶摄入的铅和镉似乎是安全的,尽管在 18 项铅研究中,有两项研究的 THQ 值超过了 1,在 16 项镉研究中,有一项研究的 THQ 值超过了 1。
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引用次数: 0
A modification of the dimethylglyoxime method for Nickel determination: Application in bioremediation processes 改进二甲基乙二醛肟法测定镍含量:在生物修复过程中的应用
Pub Date : 2024-04-16 DOI: 10.1016/j.jtemin.2024.100130
Micaela B. Gómez Jousse , Gisela Ferraro , Federico J. Pomiro , Daniel M. Pasquevich , Carolina Bagnato

Background

Environmental contamination with nickel is increasing due to the discharge of industrial effluents and other anthropogenic activities. Therefore, the improvement of methods for monitoring nickel concentration is of great value. The dimethylglyoxime (DMG) method is used to determine the nickel concentration in aqueous solutions. This method requires the oxidation of Ni(II) to Ni(IV) by bromine water before adding DMG, which is necessary to complete color development. The original method uses more than 50 mL of final reagent volume per sample. In this study, a volume reduction of the DMG method was performed.

Results

A volume reduction of 1 mL per sample was successfully achieved for the DMG method. The working range was 0 - 10 mg Ni(II) L−1. The specified limits of detection and quantification (LOQ and LOD) were 1.18 and 0.41 mg L−1 respectively. A comparative analysis with atomic absorption spectroscopy (AAS) showed no significant differences between both methods for nickel determination. The modified DMG method was effective for the measurement of nickel in experimental samples from a bioremediation assay.

Conclusion

The modified DMG method offers considerable advantages. The modified method reduces the volume of reagents used from 50 mL to just 1 mL. The requirement of smaller volume of each reagent is economically favorable, and consequently the amount of passive waste generated is reduced. It is easily reproducible in a laboratory with access to a spectrophotometer and simple reagents. In addition, the possibility to measure samples from bioremediation assays is an advantage.

背景由于工业废水的排放和其他人为活动,镍对环境的污染日益严重。因此,改进镍浓度监测方法具有重要价值。二甲基乙二醛肟(DMG)法可用于测定水溶液中的镍浓度。这种方法需要先用溴水将 Ni(II) 氧化成 Ni(IV),然后再加入 DMG,这是完成显色的必要条件。最初的方法每个样品使用的最终试剂体积超过 50 毫升。本研究对 DMG 方法进行了体积缩减。工作范围为 0 - 10 mg Ni(II) L-1。检测限和定量限(LOQ 和 LOD)分别为 1.18 mg L-1 和 0.41 mg L-1。与原子吸收光谱法(AAS)的比较分析表明,这两种方法在镍的测定上没有显著差异。改良的 DMG 方法可有效测定生物修复实验样品中的镍含量。改进后的方法将试剂用量从 50 mL 减少到 1 mL。减少每种试剂的用量在经济上是有利的,从而减少了被动废物的产生量。在有分光光度计和简单试剂的实验室中,该方法很容易重复使用。此外,它还可以测量生物修复试验的样品。
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引用次数: 0
Assessment of titanium and cobalt urinary release from dental implants by ICP-MS: A case-control study 利用 ICP-MS 评估牙科植入物中钛和钴的尿释放量:一项病例对照研究
Pub Date : 2024-04-15 DOI: 10.1016/j.jtemin.2024.100126
Hadil Gribi , Aya Guenfoud , Anissa Zergui , Mokhtar Eddine Djouad

Introduction

Dental implants are medical devices designed to replace missing teeth. They are usually made of titanium and cobalt. The present study aimed to evaluate the systematic release of cobalt and titanium in patients with dental implants.

Materials and methods

The present case-control study was conducted in dentistry establishments of the region of Chlef and included 24 patients with dental implants (group P) and 24 control subjects (group C). Titanium and cobalt urinary evels were quantified using Inductively Coupled Plasma Mass Spectrometry. The Shapiro–Wilk and Mann-whitney statistical tests were performed using R software.

Results

Assessed levels ranged from 0.001 to 0.025 and 0.020–3.900 ug.g 1 of creatinine for titanium and cobalt respectively. No statistically significant differences in titanium and cobalt urinary concentrations were found between the Group P and C (p = 0.521 and p = 0.577 for titanium and cobalt respectively). No statistically significant difference in titanium urinary levels was found between the smokers and non-smokers (p = 0.137). However, a statistically significant difference in cobalt urinary levels was found between the smokers and non-smokers (p = 0.002). In addition, a statistically significant difference in titanium and cobalt urinary levels was found between the subjects with and without orthopaedic implant (p = 0.001).

Conclusion

The results revealed that there was no significant release of titanium and cobalt through dental implants in the studied population. Further studies with multidisciplinary approach, long-term follow-up and larger sample are required to evaluate other metals release from dental and orthopaedic implants.

导言 牙科植入物是一种医疗器械,用于替换缺失的牙齿。它们通常由钛和钴制成。本研究旨在评估牙科植入物患者体内钴和钛的系统性释放。材料和方法本病例对照研究在 Chlef 地区的牙科机构进行,包括 24 名牙科植入物患者(P 组)和 24 名对照组受试者(C 组)。采用电感耦合等离子体质谱法对尿液中的钛和钴含量进行了定量。结果钛和钴的评估水平分别为 0.001 至 0.025 微克/克肌酐和 0.020 至 3.900 微克/克肌酐。在 P 组和 C 组之间,钛和钴的尿液浓度没有明显的统计学差异(钛和钴分别为 p = 0.521 和 p = 0.577)。吸烟者和非吸烟者尿液中的钛含量没有明显的统计学差异(p = 0.137)。然而,吸烟者和非吸烟者尿液中钴含量的差异有统计学意义(p = 0.002)。结论:研究结果表明,在所研究的人群中,钛和钴没有通过牙科植入物明显释放出来。要评估牙科和矫形外科植入物中其他金属的释放情况,还需要通过多学科方法、长期随访和更大样本进行进一步研究。
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引用次数: 0
Necroptosis in aluminum-induced neural cells and animal models of Alzheimer's disease 铝诱导的神经细胞和阿尔茨海默病动物模型中的坏死现象
Pub Date : 2024-04-09 DOI: 10.1016/j.jtemin.2024.100125
Qinli Zhang , Qiao Niu

Introduction

Progressive neural cell loss is a pathological hallmark of Alzheimer's disease (AD). Environmental factors should be taken into consideration due to their epigenetic link to AD, and also because most of the causal environmental factors are preventable. Aluminum (Al) as a common risk environmental factor has been reported to be related to AD. Nonetheless, the nature, time duration, and molecular mechanism of neural cell death in Al-induced AD remain poorly understood. The present article reviews the role of necroptosis, as a novel cell death pathway, in Al-induced AD models in vitro and in vivo.

Methods

In the present review, Al-induced necroptosis is summarized in terms of neural cell death and AD animal models induced by Al compounds. Furthermore, a major role of necroptosis in AD is highlighted by comparing studies of apoptosis and autophagy in Al-induced neural cell death and AD animal models.

Results

Current research on Al-induced necroptosis has been summarized in Al-treated neural cells and animal AD models. Treatment with Necrostatin-1 (Nec-1) as its specific inhibitor could down-regulate expression of cell death and necroptosis-related proteins; finally, AD-related expression of the signal pathway declined accordingly. The results consistently implied that Al could induce necroptosis, and that Nec-1 could suppress neural cell death pathways not only in Al-induced necroptosis but also in apoptosis and autophagy. Compared with the inhibitors of apoptosis and autophagy, the effects of Nec-1 were more prominent. It indicated that necroptosis is a dominant cell death pathway in Al-treated neural cells and animal models.

Conclusion

Based on the relative literature, it has been suggested that necroptosis is involved in the process of Al-induced AD. It implies that Nec-1 represents a promising anti-Alzheimer's approach and has potential theoretical value in environmental factor Al-induced AD neuropathologies.

导言渐进性神经细胞丧失是阿尔茨海默病(AD)的病理特征。由于环境因素与阿尔茨海默病存在表观遗传学上的联系,而且大多数致病环境因素都是可以预防的,因此环境因素应被纳入考虑范围。据报道,铝(Al)作为一种常见的风险环境因素与阿兹海默症有关。然而,人们对铝诱导的注意力缺失症中神经细胞死亡的性质、持续时间和分子机制仍然知之甚少。本文综述了坏死作为一种新型细胞死亡途径在铝诱导的体外和体内AD模型中的作用。方法本文从神经细胞死亡和铝化合物诱导的AD动物模型的角度总结了铝诱导的坏死。此外,通过比较铝诱导的神经细胞死亡和 AD 动物模型中细胞凋亡和自噬的研究,强调了坏死在 AD 中的重要作用。用Necrostatin-1(Nec-1)作为其特异性抑制剂可以下调细胞死亡和坏死相关蛋白的表达;最后,AD相关信号通路的表达也相应下降。这些结果一致表明,铝能诱导坏死,而 Nec-1 不仅能抑制铝诱导的坏死,还能抑制细胞凋亡和自噬。与抑制细胞凋亡和自噬的抑制剂相比,Nec-1 的作用更为突出。结论根据相关文献,有学者认为坏死参与了 Al 诱导的注意力缺失症的过程。这意味着,Nec-1 是一种很有前景的抗阿尔茨海默氏症方法,在环境因素铝诱导的阿尔茨海默氏症神经病理学方面具有潜在的理论价值。
{"title":"Necroptosis in aluminum-induced neural cells and animal models of Alzheimer's disease","authors":"Qinli Zhang ,&nbsp;Qiao Niu","doi":"10.1016/j.jtemin.2024.100125","DOIUrl":"https://doi.org/10.1016/j.jtemin.2024.100125","url":null,"abstract":"<div><h3>Introduction</h3><p>Progressive neural cell loss is a pathological hallmark of Alzheimer's disease (AD). Environmental factors should be taken into consideration due to their epigenetic link to AD, and also because most of the causal environmental factors are preventable. Aluminum (Al) as a common risk environmental factor has been reported to be related to AD. Nonetheless, the nature, time duration, and molecular mechanism of neural cell death in Al-induced AD remain poorly understood. The present article reviews the role of necroptosis, as a novel cell death pathway, in Al-induced AD models in vitro and in vivo.</p></div><div><h3>Methods</h3><p>In the present review, Al-induced necroptosis is summarized in terms of neural cell death and AD animal models induced by Al compounds. Furthermore, a major role of necroptosis in AD is highlighted by comparing studies of apoptosis and autophagy in Al-induced neural cell death and AD animal models.</p></div><div><h3>Results</h3><p>Current research on Al-induced necroptosis has been summarized in Al-treated neural cells and animal AD models. Treatment with Necrostatin-1 (Nec-1) as its specific inhibitor could down-regulate expression of cell death and necroptosis-related proteins; finally, AD-related expression of the signal pathway declined accordingly. The results consistently implied that Al could induce necroptosis, and that Nec-1 could suppress neural cell death pathways not only in Al-induced necroptosis but also in apoptosis and autophagy. Compared with the inhibitors of apoptosis and autophagy, the effects of Nec-1 were more prominent. It indicated that necroptosis is a dominant cell death pathway in Al-treated neural cells and animal models.</p></div><div><h3>Conclusion</h3><p>Based on the relative literature, it has been suggested that necroptosis is involved in the process of Al-induced AD. It implies that Nec-1 represents a promising anti-Alzheimer's approach and has potential theoretical value in environmental factor Al-induced AD neuropathologies.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"8 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000107/pdfft?md5=0ae3285a4c7ba8004f245616186c7e21&pid=1-s2.0-S2773050624000107-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium as a powerful trace element for mitigation of plant salt stress: A review 硒是缓解植物盐胁迫的有效微量元素:综述
Pub Date : 2024-04-02 DOI: 10.1016/j.jtemin.2024.100123
Bouzid Nedjimi

Background

Selenium (Se) is an important trace element with several positive impacts for animal and human health. Salinity poses a substantial problem to agriculture and crop production worldwide, that necessitates innovative procedures to enhance salt tolerance of crop species. Selenium (Se) and Selenium nanoparticles (Se–NPs) application is a simple and effective practice for boosting growth and productivity of crop species under salt conditions.

Objective

The aim of this review was to summarize recent literature on about the efficiency of Se and Se–NPs amendments to enhance plant growth and crop productivity under saline conditions.

Methodology

In this review, we have delved the effects of Se and Se-NPs on seed priming and germination under salt stress. We explored the effects of Se on plant growth, mineral nutrition and photosynthesis activity. Different effects modulated by Se and Se-NPs to improve the water relations, oxidative defense system and osmolyte production are also reviewed.

Conclusion

We have concluded that Se and Se-NPs supply offer a very promising solution to improve plant growth and salt stress tolerance of crop species. We emphasize the requirement of further investigations to elucidate the forms, accurate doses, and timing of Se amendments on plants subjected to salt stress, and to assess their long-term environmental impacts.

背景硒(Se)是一种重要的微量元素,对动物和人类健康具有多种积极影响。盐碱化给全球农业和作物生产带来了严重问题,因此有必要采用创新方法来提高作物品种的耐盐性。硒(Se)和硒纳米粒子(Se-NPs)的应用是在盐分条件下促进作物生长和提高其产量的一种简单而有效的方法。方法在这篇综述中,我们探讨了硒和硒纳米粒子对盐胁迫下种子萌发和发芽的影响。我们探讨了 Se 对植物生长、矿质营养和光合作用的影响。结论我们得出结论,Se 和 Se-NPs 的供应为改善作物物种的植物生长和盐胁迫耐受性提供了一个非常有前景的解决方案。我们强调需要开展进一步研究,以阐明硒添加剂对盐胁迫植物的作用形式、准确剂量和时机,并评估其对环境的长期影响。
{"title":"Selenium as a powerful trace element for mitigation of plant salt stress: A review","authors":"Bouzid Nedjimi","doi":"10.1016/j.jtemin.2024.100123","DOIUrl":"https://doi.org/10.1016/j.jtemin.2024.100123","url":null,"abstract":"<div><h3>Background</h3><p>Selenium (Se) is an important trace element with several positive impacts for animal and human health. Salinity poses a substantial problem to agriculture and crop production worldwide, that necessitates innovative procedures to enhance salt tolerance of crop species. Selenium (Se) and Selenium nanoparticles (Se–NPs) application is a simple and effective practice for boosting growth and productivity of crop species under salt conditions.</p></div><div><h3>Objective</h3><p>The aim of this review was to summarize recent literature on about the efficiency of Se and Se–NPs amendments to enhance plant growth and crop productivity under saline conditions.</p></div><div><h3>Methodology</h3><p>In this review, we have delved the effects of Se and Se-NPs on seed priming and germination under salt stress. We explored the effects of Se on plant growth, mineral nutrition and photosynthesis activity. Different effects modulated by Se and Se-NPs to improve the water relations, oxidative defense system and osmolyte production are also reviewed.</p></div><div><h3>Conclusion</h3><p>We have concluded that Se and Se-NPs supply offer a very promising solution to improve plant growth and salt stress tolerance of crop species. We emphasize the requirement of further investigations to elucidate the forms, accurate doses, and timing of Se amendments on plants subjected to salt stress, and to assess their long-term environmental impacts.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"8 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000089/pdfft?md5=391dcec9f77f072a00f75bfe39998ee1&pid=1-s2.0-S2773050624000089-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selenium in plant-based beverages: How can in vitro bioaccessibility contribute to an accurate daily intake? 植物饮料中的硒:体外生物可及性如何有助于准确计算每日摄入量?
Pub Date : 2024-04-02 DOI: 10.1016/j.jtemin.2024.100124
José Luan da Paixão Teixeira, Raquel Fernanda Milani, Marcelo Antonio Morgano

Background

Lactose intolerance, cow milk protein allergy, and environmental and ethical concerns drive the global market for plant-based beverages (PPBs). Despite this, data on the occurrence of selenium (Se) in these beverages are scarce.

Objective

The objectives of this study were to assess total selenium and determine the bioaccessible fractions in plant-based beverages (PBBs) from cereals, oilseeds, and pumpkin seeds, using an in vitro static method to simulate human digestion; and estimate the contribution these beverages have to the reference daily intake (RDI) for children and adults.

Methodology

The study involved beverages made under laboratory conditions. Samples and extracts were submitted to acid digestion (ultrasonic and block digester); total and bioaccessible Se levels were determined by ICP-MS. In vitro bioaccessibility was assessed using the INFOGEST protocol.

Results

The results revealed a wide variation in Se content in the studied plant-based beverages from 10.3 µg kg−1 (sunflower seeds) to 3509 µg kg−1 (Brazil nuts). The bioaccessibility of Se was found only in PBBs made from oilseeds with macadamia, cashew and Brazil nut, with a variation in values from 86 to 96 %. The Se content and its bioaccessible fraction of Brazil nut PBB may contribute to 1276 % and 1218 % of the RDI for children and adults, respectively.

Conclusions

The Se content varied among samples of cereals, oilseeds and pumpkin seeds, reflecting the diversity in the studied PBBs. Only PBBs containing oilseeds (macadamia, cashews, and Brazil nuts) exhibited measurable amounts of bioaccessible Se, indicating an association with the raw material. However, the consumption of the PBB containing Brazil nuts may pose a risk of adverse effects, due to its high contribution to the RDI in both children and adults.

背景乳糖不耐症、牛奶蛋白过敏以及环境和道德问题推动了全球植物饮料(PPB)市场的发展。本研究的目的是采用模拟人体消化的体外静态法,评估谷物、油籽和南瓜籽等植物饮料(PBBs)中的总硒含量,并确定其中的生物可利用部分;同时估算这些饮料对儿童和成人每日参考摄入量(RDI)的贡献。将样品和提取物进行酸消化(超声波和块状消化器);用 ICP-MS 测定硒的总含量和生物可及性。结果显示,所研究的植物饮料中的硒含量差异很大,从 10.3 µg kg-1(葵花籽)到 3509 µg kg-1(巴西坚果)不等。硒的生物可接受性仅存在于由油籽、澳洲坚果、腰果和巴西坚果制成的多溴联苯中,其数值从 86% 到 96% 不等。结论 谷物、油籽和南瓜籽样品中的硒含量各不相同,反映了所研究的多溴联苯的多样性。只有含有油籽的多溴联苯(澳洲坚果、腰果和巴西坚果)显示了可测量的生物可利用硒含量,这表明多溴联苯与原材料有关。不过,食用含有巴西坚果的多溴联苯可能会带来不良影响的风险,因为它在儿童和成人的每日允许摄入量中所占比例都很高。
{"title":"Selenium in plant-based beverages: How can in vitro bioaccessibility contribute to an accurate daily intake?","authors":"José Luan da Paixão Teixeira,&nbsp;Raquel Fernanda Milani,&nbsp;Marcelo Antonio Morgano","doi":"10.1016/j.jtemin.2024.100124","DOIUrl":"https://doi.org/10.1016/j.jtemin.2024.100124","url":null,"abstract":"<div><h3>Background</h3><p>Lactose intolerance, cow milk protein allergy, and environmental and ethical concerns drive the global market for plant-based beverages (PPBs). Despite this, data on the occurrence of selenium (Se) in these beverages are scarce.</p></div><div><h3>Objective</h3><p>The objectives of this study were to assess total selenium and determine the bioaccessible fractions in plant-based beverages (PBBs) from cereals, oilseeds, and pumpkin seeds, using an <em>in vitro</em> static method to simulate human digestion; and estimate the contribution these beverages have to the reference daily intake (RDI) for children and adults.</p></div><div><h3>Methodology</h3><p>The study involved beverages made under laboratory conditions. Samples and extracts were submitted to acid digestion (ultrasonic and block digester); total and bioaccessible Se levels were determined by ICP-MS. <em>In vitro</em> bioaccessibility was assessed using the INFOGEST protocol.</p></div><div><h3>Results</h3><p><em>The results revealed a wide variation in Se content in the studied plant-based beverages</em> from 10.3 µg kg<sup>−1</sup> (sunflower seeds) to 3509 µg kg<sup>−1</sup> (Brazil nuts). The bioaccessibility of Se was found only in PBBs made from oilseeds with macadamia, cashew and Brazil nut, with a variation in values from 86 to 96 %. The Se content and its bioaccessible fraction of Brazil nut PBB may contribute to 1276 % and 1218 % of the RDI for children and adults, respectively.</p></div><div><h3>Conclusions</h3><p>The Se content varied among samples of cereals, oilseeds and pumpkin seeds, reflecting the diversity in the studied PBBs. Only PBBs containing oilseeds (macadamia, cashews, and Brazil nuts) exhibited measurable amounts of bioaccessible Se, indicating an association with the raw material. However, the consumption of the PBB containing Brazil nuts may pose a risk of adverse effects, due to its high contribution to the RDI in both children and adults.</p></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"8 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773050624000090/pdfft?md5=6d2c2037290b137a9ea31d82423390e9&pid=1-s2.0-S2773050624000090-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140533854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of trace elements and minerals
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