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Carcinogenic and non-carcinogenic health risk assessment of heavy metals in water from selected oil pollution-prone communities in the Niger delta region 尼日尔三角洲地区某些易受石油污染社区水中重金属的致癌和非致癌健康风险评估
Pub Date : 2025-10-09 DOI: 10.1016/j.jtemin.2025.100266
Benjamin Onozeyi Dimowo , Adewole Michael Gbadebo , Adewale Matthew Taiwo , Olatunbosun Samuel Sojinu , Moses Onaivi Dimowo
Water is vital to human health, yet its quality is threatened by industrial activity and crude oil pollution. This study evaluated water quality and associated carcinogenic and non-carcinogenic health risks from ten heavy metals for infants, children, teenagers, and adults through oral and dermal exposure routes in selected communities of Edo and Cross River States. A total of 113 samples from boreholes, wells, and a surface water source were analysed for As, Pb, Cd, Cr, Ni, Zn, Fe, Cu, Mn, and Ag using ICP-MS. Health risks were quantified following USEPA protocols. Findings revealed elevated concentrations of Pb (0.03±0.000–0.066±0.001 mg/L), Cd (0.001±0.001–0.011±0.002 mg/L) and Fe (0.301±0.078–0.950±0.000 mg/L) exceeding regulatory thresholds (WHO, SON, and NESREA). Water Quality Index (WQI) classed 13 water sources as “good”, 55 “poor,” 31 “very poor,” and 14 unsuitable for use. Degree of Contamination (Cdeg) values (4.23–16.27) and Contamination Factor (CF) values confirmed widespread contamination, particularly from Pb (1.60–9.10), Cd (0.67–4.33), Ni (0.10–2.80), and Fe (0.13–4.01). Pollution Load Index (PLI) values (0.10–0.46) and Nemerow Pollution Index (Pn) values (1.24–2.28) on the other hand suggested no acute pollution. Non-carcinogenic health risks were primarily linked to cadmium (HQ>1), especially for infants, with all 113 samples posing potential risks (HI>1). Total mean cancer risk exceeded the USEPA threshold (1 × 10⁻⁴) in all samples, with infants (1.80 × 10⁻²) being most vulnerable. The contribution of metals to the cancer risk was in the order, Ni>Fe>As>Cr>Cd>Pb. These findings underscore the urgent need for continuous monitoring, effective water treatment, and stricter environmental regulation.
水对人类健康至关重要,但其质量受到工业活动和原油污染的威胁。本研究评估了江户州和克罗斯河州选定社区通过口腔和皮肤接触途径对婴儿、儿童、青少年和成人造成的十种重金属的水质和相关的致癌和非致癌健康风险。采用ICP-MS对来自钻孔、井和地表水水源的113个样品进行了砷、铅、镉、铬、镍、锌、铁、铜、锰和银的分析。健康风险按照美国环保局的方案进行了量化。结果显示,铅(0.03±0.000 ~ 0.066±0.001 mg/L)、镉(0.001±0.001 ~ 0.011±0.002 mg/L)和铁(0.301±0.078 ~ 0.950±0.000 mg/L)的浓度均高于规定阈值(WHO、SON和NESREA)。水质指数(WQI)将13个水源划分为“良好”,55个为“差”,31个为“很差”,14个不适合使用。污染程度(Cdeg)值(4.23-16.27)和污染因子(CF)值证实了广泛的污染,特别是铅(1.60-9.10),Cd (0.67-4.33), Ni(0.10-2.80)和Fe(0.13-4.01)。污染负荷指数(PLI)值(0.10 ~ 0.46)和Nemerow污染指数(Pn)值(1.24 ~ 2.28)表明没有急性污染。非致癌性健康风险主要与镉有关(HQ>1),特别是对婴儿而言,所有113个样本都存在潜在风险(HQ>1)。所有样本的总平均癌症风险都超过了美国环保局的阈值(1 × 10⁻),其中婴儿(1.80 × 10⁻)是最脆弱的。金属对癌症风险的贡献顺序为:Ni>;Fe>As>Cr>Cd>Pb。这些发现强调了持续监测、有效的水处理和更严格的环境法规的迫切需要。
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引用次数: 0
Spatio-temporal evaluation of urbanization impacts on groundwater quality and the risk of human exposure to nitrate-contaminated groundwater 城市化对地下水水质影响及人体硝酸盐污染风险的时空评价
Pub Date : 2025-10-03 DOI: 10.1016/j.jtemin.2025.100265
Joseph I. Nwachukwu , Leon J. Clarke , Francis Q. Brearley , Elias Symeonakis , Chika V. Nwachukwu

Background

The study investigates how spatial factors linked to urbanisation in Owerri, Nigeria, contribute to groundwater contamination. It also evaluates the associated public health risks, particularly from poorly designed private boreholes in environmentally sensitive areas.

Methodology

Groundwater was sampled in two seasons across a ∼100 km² area and analysed for major ions and DOC using ion chromatography and a Shimadzu TOC analyser, respectively. Water Quality Index (WQI) and Synthetic Pollution Index (SPI) were used to evaluate the drinking suitability of groundwater. A non-cancer risk model assessed age-specific health risks. Parameter relationships and variations were analysed using correlation and ANOVA, with sampling locations mapped using a handheld GPS.

Results

Findings showed nitrate (NO3-) as a critical contaminant having exceeded the World Health Organization’s (WHO) permissible limit (PL) of 50 µg ml-1 in c.12 % and 26 % of boreholes in the respective seasons. DOC exceeded the WHO limit in about 83 % of sites during the rainy season but dropped to 2 % in the dry season. Nitrate pollution aligned with urban density patterns, while water quality declined from rainy to dry season, with 70 % to 25 % (WQI) and 13 % to 43 % (SPI) classified as good. Hazard quotients above 1 were recorded in 17 % to 32 % of the population during the rainy season and doubled in the dry season, indicating heightened health risks.

Conclusion

The study revealed significant seasonal variation in NO₃⁻ and high DOC levels, posing health risks to young children, and recommends Integrated Vulnerable Zone Management (IVZM) for safe water and sustainable urban planning in line with SDG 3.
该研究调查了与尼日利亚奥韦里城市化相关的空间因素如何导致地下水污染。它还评估了相关的公共健康风险,特别是来自环境敏感地区设计不良的私人钻孔的风险。方法:在约100平方公里的区域内,分两个季节对地下水进行采样,分别使用离子色谱法和岛津TOC分析仪分析主要离子和DOC。采用水质指数(WQI)和综合污染指数(SPI)评价地下水饮用适宜性。一个非癌症风险模型评估了特定年龄的健康风险。使用相关性和方差分析分析参数关系和变化,使用手持式GPS绘制采样位置。结果:在不同季节,分别有12%和26%的钻孔的硝酸盐(NO3-)超过了世界卫生组织(WHO)的允许限值(50µg ml-1)。雨季期间,约83%的地点的DOC超过了世卫组织的限值,但在旱季则降至2%。硝酸盐污染与城市密度模式一致,而水质从雨季到旱季呈下降趋势,其中70%至25% (WQI)和13%至43% (SPI)为良好。在雨季,17%至32%的人口危险系数高于1,在旱季则增加一倍,表明健康风险增加。该研究揭示了NO₃⁻和高DOC水平的显著季节性变化,对幼儿构成健康风险,并建议采用综合脆弱区管理(IVZM)来实现安全用水和符合可持续发展目标3的可持续城市规划。
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引用次数: 0
Understanding trace elements dynamics and environmental health: insights from Fish Mortality in Rajshahi, Bangladesh 了解微量元素动态和环境健康:来自孟加拉国拉杰沙希鱼类死亡率的见解
Pub Date : 2025-09-24 DOI: 10.1016/j.jtemin.2025.100264
A․H․M․Selim Reza , Md․Shazzadur Rahman , Fazal Md․Mohi Shine , Md․Abu Bakar Siddique , Md․Abdur Rahman , Sudip Saha , Abu Bakar Siddique , Fawzia Adib Flowra

Introduction

This study investigates the combined impact of trace metal contamination and environmental factors on fish mortality in aquaculture ponds in the Rajshahi region of Bangladesh. The primary objective is to assess how physicochemical parameters and trace metal concentrations interact with climatic conditions to influence fish health and survival.

Materials and Methods

Water, sediment, and fish tissue samples were collected and analyzed for arsenic (As), mercury (Hg), chromium (Cr), cadmium (Cd), and lead (Pb) using Atomic Absorption Spectrometry (AAS-240FS). Key physicochemical parameters such as pH, electrical conductivity (EC), total dissolved solids (TDS), and dissolved oxygen (DO) were measured. Climatic variables, including relative humidity and temperature, were recorded to evaluate their relationship with DO levels and fish mortality events.

Results and Discussion

Mean values of pH, EC, and TDS were 6.77, 433.4 µS cm−1, and 209 mg L−1, respectively. Trace metal concentrations in water followed the order Pb > As > Cr > Hg > Cd; in sediment, Cr > Pb > As > Hg > Cd; and in fish tissue, Cr > Pb > As > Hg > Cd. A significant inverse correlation was found between high relative humidity (90–95 %) and DO levels, which decreased from 4.00 mg L−1 to 1.08 mg L−1 well below the critical threshold of 5–6 mg L−1 required for fish survival. Additionally, TDS exhibited a negative correlation with DO and a positive correlation with sedimentary arsenic, indicating that siltation from heavy rainfall contributes to oxygen depletion. The highest fish mortality, recorded on September 1, 2020, coincided with overcast conditions, elevated temperatures, and reduced photosynthetic activity, all of which exacerbated hypoxic stress.

Conclusion

The findings highlight the complex interplay between environmental stressors and trace metal pollution in aquaculture ponds. Regular water quality monitoring, pollution control, and adaptive management strategies are essential to reduce fish mortality risks and ensure the long-term sustainability of aquaculture in the region.
本研究调查了痕量金属污染和环境因素对孟加拉国Rajshahi地区水产养殖池塘鱼类死亡率的综合影响。主要目的是评估理化参数和微量金属浓度如何与气候条件相互作用,从而影响鱼类健康和生存。材料与方法采用原子吸收光谱法(AAS-240FS)对水、沉积物和鱼类组织样品中的砷(As)、汞(Hg)、铬(Cr)、镉(Cd)和铅(Pb)进行分析。测量了关键的理化参数,如pH、电导率(EC)、总溶解固体(TDS)和溶解氧(DO)。记录了包括相对湿度和温度在内的气候变量,以评估它们与DO水平和鱼类死亡事件的关系。结果与讨论pH、EC和TDS的平均值分别为6.77、433.4µS cm−1和209 mg L−1。水中微量金属的浓度顺序为Pb >; As > Cr > Hg >;沉积物中Cr >; Pb > As > Hg > Cd;在鱼类组织中,Cr > Pb > As > Hg > Cd。在高相对湿度(90 - 95%)和DO水平之间发现了显著的负相关,DO水平从4.00 mg L - 1下降到1.08 mg L - 1,远低于鱼类生存所需的5-6 mg L - 1的临界阈值。此外,TDS与DO呈负相关,与沉积砷呈正相关,表明强降雨淤积导致氧耗竭。2020年9月1日记录的鱼类死亡率最高,恰逢阴天、气温升高和光合活性降低,所有这些都加剧了缺氧应激。结论环境应激因素与水产养殖池塘微量金属污染之间存在复杂的相互作用。定期进行水质监测、污染控制和适应性管理战略对于降低鱼类死亡风险和确保该区域水产养殖的长期可持续性至关重要。
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引用次数: 0
Elemental bioaccumulation as trophic discriminator in Southeast Alaska gray wolves: Marine-terrestrial diet shifts 元素生物积累作为阿拉斯加东南部灰狼的营养鉴别:海洋-陆地饮食的转变
Pub Date : 2025-09-22 DOI: 10.1016/j.jtemin.2025.100263
Miranda Brohman , Gretchen H. Roffler , Dimitrios G. Giarikos , David W. Kerstetter , Amy C. Hirons
Gray wolves (Canis lupus) in Southeast Alaska exhibit diverse foraging strategies shaped by regional ecological factors. Stable isotope (δ13C and δ15N) and trace element (TE) analyses were used to evaluate dietary patterns and contaminant exposure in four wolf populations from northern Lynn Canal (Douglas Island, Juneau, Gustavus, and Pleasant Island) from wolf hair samples collected from 2013–2021, along with sea otter (Enhydra lutris) hair in wolf scat collected in 2018–2019. Stable isotope ratios revealed that Juneau wolves predominantly consume terrestrial prey such as Sitka black-tailed deer (Odocoileus hemionus sitkensis) and mountain goats (Oreamnos americanus), and wolves on Douglas Island mainly consume Sitka black-tailed deer. In contrast, wolves from Gustavus and Pleasant Island exhibited enriched isotopic signatures, indicating a significant incorporation of marine-derived prey, particularly sea otters. Analysis of TEs revealed higher concentrations in wolves consuming marine-based diets, highlighting potential bioaccumulation risks compared to terrestrial-based diets. Gustavus wolves had the highest geometric mean concentrations for Cr (1.63 µg/g), Hg (4.24 µg/g), and Mo (0.180 µg/g) while Pleasant Island wolves had the highest for Al (153 µg/g), Cd (0.160 µg/g), Co (0.208 µg/g), Fe (343 µg/g), Mn (52.1 µg/g), and V (0.592 µg/g). The Se:Hg ratio also indicated a higher likelihood of mercury toxicity in all wolf populations, underscoring environmental health concerns. Assessing the dietary preferences and prey availability of apex predators, alongside the potential risks posed by elevated TE concentrations, is essential for informing targeted conservation strategies aimed at safeguarding these species across both coastal and inland Southeast Alaska.
阿拉斯加东南部灰狼(Canis lupus)表现出受区域生态因素影响的多样化觅食策略。采用稳定同位素(δ13C和δ15N)和微量元素(TE)分析方法,从2013-2021年收集的林恩运河北部(道格拉斯岛、朱诺岛、古斯塔夫斯岛和普莱森特岛)的狼毛样本和2018-2019年收集的狼粪中海獭(Enhydra lutris)毛中评估了四个狼种群的饮食模式和污染物暴露情况。稳定同位素比值表明,朱诺狼主要捕食陆地猎物锡特卡黑尾鹿(Odocoileus hemionus sitkensis)和美洲山羊(Oreamnos americanus),道格拉斯岛的狼主要捕食锡特卡黑尾鹿。相比之下,来自古斯塔夫斯和普莱森特岛的狼表现出丰富的同位素特征,这表明它们有明显的海洋猎物,尤其是海獭。对TEs的分析显示,食用海洋食物的狼体内的TEs浓度较高,与食用陆地食物相比,突出了潜在的生物积累风险。古斯塔夫狼的几何平均浓度最高,分别为铬(1.63µg/g)、汞(4.24µg/g)和钼(0.180µg/g),而喜乐岛狼的几何平均浓度最高,分别为铝(153µg/g)、镉(0.160µg/g)、钴(0.208µg/g)、铁(343µg/g)、锰(52.1µg/g)和钒(0.592µg/g)。硒汞比还表明,所有狼种群中汞中毒的可能性更高,强调了环境健康问题。评估顶端捕食者的饮食偏好和猎物可得性,以及TE浓度升高带来的潜在风险,对于制定有针对性的保护策略至关重要,这些策略旨在保护阿拉斯加东南部沿海和内陆的这些物种。
{"title":"Elemental bioaccumulation as trophic discriminator in Southeast Alaska gray wolves: Marine-terrestrial diet shifts","authors":"Miranda Brohman ,&nbsp;Gretchen H. Roffler ,&nbsp;Dimitrios G. Giarikos ,&nbsp;David W. Kerstetter ,&nbsp;Amy C. Hirons","doi":"10.1016/j.jtemin.2025.100263","DOIUrl":"10.1016/j.jtemin.2025.100263","url":null,"abstract":"<div><div>Gray wolves (<em>Canis lupus</em>) in Southeast Alaska exhibit diverse foraging strategies shaped by regional ecological factors. Stable isotope (δ<sup>13</sup>C and δ<sup>15</sup>N) and trace element (TE) analyses were used to evaluate dietary patterns and contaminant exposure in four wolf populations from northern Lynn Canal (Douglas Island, Juneau, Gustavus, and Pleasant Island) from wolf hair samples collected from 2013–2021, along with sea otter (<em>Enhydra lutris</em>) hair in wolf scat collected in 2018–2019. Stable isotope ratios revealed that Juneau wolves predominantly consume terrestrial prey such as Sitka black-tailed deer (<em>Odocoileus hemionus sitkensis</em>) and mountain goats (<em>Oreamnos americanus</em>), and wolves on Douglas Island mainly consume Sitka black-tailed deer. In contrast, wolves from Gustavus and Pleasant Island exhibited enriched isotopic signatures, indicating a significant incorporation of marine-derived prey, particularly sea otters. Analysis of TEs revealed higher concentrations in wolves consuming marine-based diets, highlighting potential bioaccumulation risks compared to terrestrial-based diets. Gustavus wolves had the highest geometric mean concentrations for Cr (1.63 µg/g), Hg (4.24 µg/g), and Mo (0.180 µg/g) while Pleasant Island wolves had the highest for Al (153 µg/g), Cd (0.160 µg/g), Co (0.208 µg/g), Fe (343 µg/g), Mn (52.1 µg/g), and V (0.592 µg/g). The Se:Hg ratio also indicated a higher likelihood of mercury toxicity in all wolf populations, underscoring environmental health concerns. Assessing the dietary preferences and prey availability of apex predators, alongside the potential risks posed by elevated TE concentrations, is essential for informing targeted conservation strategies aimed at safeguarding these species across both coastal and inland Southeast Alaska.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"14 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145266274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of peeled and unpeeled white and red cocoa yam varieties by mineral and vitamin profiles 去皮和未去皮的白色和红色可可山药品种的矿物质和维生素谱的比较评价
Pub Date : 2025-09-12 DOI: 10.1016/j.jtemin.2025.100262
Elijah O. Odesanmi , Deborah O. Jesusanmi , Olorunfemi R. Molehin , Modupe A Ogundare , Omotade I. Oloyede , Yemisi Alli Smith , Bukola T. Aluko , Olajumoke O. Ojo , Olorunfemi Ojo , Seun Akomolafe

Background

Cocoa yam (Xanthosoma sagittifolium) is a starchy root vegetable that is widely consumed in tropical regions. As an underutilized crop, its potential as a functional food remains largely unexplored.

Objectives

The aim of this current study was to compare peeled and unpeeled white and red cocoa yam varieties, specifically by their emergent mineral and vitamin profiles

Methods

The research employed an Atomic Absorption Spectrophotometer (AAS) to detect minerals like iron (Fe), magnesium (Mg), lead (Pb), manganese (Mn), sodium (Na), and potassium (K), likewise HPLC-UV to detect vitamins like vitamin E,C,A and vitamin K present in peeled and unpeeled white and red cocoa yam.

Results

The mineral analysis revealed that the unpeeled red cocoa yam (URCY) and unpeeled white cocoa yam (UWCY) consistently displayed significantly higher levels of macrominerals, such as calcium (123.238±0.02 mg 100 g in UWCY and 115.793±0.56 mg 100 g in URCY), magnesium, sodium, and potassium, compared to the peeled counterparts (PWCY and PRCY). The unpeeled varieties also exhibited greater concentrations of trace minerals, including iron (17.987±0.02 mg 100g−1 in URCY and 63.320±0.03 mg 100 g in UWCY), copper, zinc, and manganese. Interestingly, all varieties had negligible levels of lead, indicating minimal contamination. The vitamin composition analysis further highlighted the importance of the peel. The unpeeled URCY variety demonstrated the highest levels of fat-soluble vitamins, such as vitamin A (3.947±0.04 μg 100g−1 URCY and 4.315±0.01 μg 100 g in UWCY), vitamin E, and vitamin K. For water-soluble vitamins, URCY also had the greatest amounts of vitamin C (8.652±0.02 mg 100g−1) and vitamin B6.

Conclusion

These findings suggest that the peel of the cocoa yam is a rich source of various essential minerals and vitamins, which are known to confer numerous health benefits. Consuming cocoa yam with the peel intact can provide greater nutritional and functional food benefits to consumers compared to peeled varieties.
可可山药是一种淀粉类根茎蔬菜,在热带地区广泛食用。作为一种未充分利用的作物,其作为功能性食品的潜力在很大程度上仍未得到开发。本研究的目的是比较去皮和未去皮的白色和红色可可山药品种,特别是它们的矿物质和维生素特征。方法研究采用原子吸收分光光度计(AAS)检测铁(Fe)、镁(Mg)、铅(Pb)、锰(Mn)、钠(Na)和钾(K)等矿物质,同样采用HPLC-UV检测去皮和未去皮的白色和红色可可山药中存在的维生素E、C、A和维生素K。结果未去皮的红可可山药(URCY)和未去皮的白可可山药(UWCY)的钙(UWCY为123.238±0.02 mg 100 g, UWCY为115.793±0.56 mg 100 g)、镁、钠和钾的含量均显著高于去皮的PWCY和PRCY。未去皮品种的微量矿物质含量也更高,包括铁(URCY为17.987±0.02 mg 100g - 1, UWCY为63.320±0.03 mg 100g)、铜、锌和锰。有趣的是,所有品种的铅含量都可以忽略不计,表明污染很小。维生素成分分析进一步强调了果皮的重要性。未去皮URCY品种的脂溶性维生素含量最高,如维生素A (URCY为3.947±0.04 μg 100g−1,UWCY为4.315±0.01 μg 100g)、维生素E和维生素k。水溶性维生素方面,URCY的维生素C(8.652±0.02 mg 100g−1)和维生素B6的含量最高。这些发现表明,可可山药的果皮是各种必需矿物质和维生素的丰富来源,已知这些矿物质和维生素对健康有许多好处。与去皮的品种相比,食用果皮完整的可可山药可以为消费者提供更多的营养和功能性食品益处。
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引用次数: 0
Health risks from the harmful mineral elements’ extractability in the Lubumbashi’s three most used medicinal plants root barks 卢本巴希三种最常用的药用植物根皮中有害矿物元素的可提取性对健康的危害
Pub Date : 2025-08-28 DOI: 10.1016/j.jtemin.2025.100261
Cedrick S. Mutombo , Cynthia M. Kibwe , Gael N. Mavungu , Henry M. Manya , Arsene T. Kabamba , Vianney N. Ntabaza , Salvius A. Bakari , Joh B. Kahumba

Background

To date, no studies have been reported on the mineral element’s extractability in medicinal plants from Lubumbashi, despite the harmful mineral element’s accumulation in medicinal plant species from this region. This study evaluates (i) the extractability of mineral elements in aqueous extracts of root barks from 3 of Lubumbashi’s most used medicinal plants and (ii) the health risk from the harmful mineral elements bioaccessibility.

Methods

Root bark powders of Oldfieldia dactyllophylla (Welw.exOliv.) J. Léonard, Phyllanthus muellerianus (Kuntze) Exell, and Securidaca longepedunculata Fresen, collected from 3 sites in the Lubumbashi region, were macerated (2 h, 6 h, 12 h, and 24 h), infused and decocted in distilled water. These extracts, corresponding crude samples (powders), and used solvent were subjected to inductively coupled plasma atomic emission spectroscopy.

Results

4 macroelements (Ca, K, Na, Mg), 6 trace elements (Co, Cu, Fe, Mn, Zn, Se), and 5 non-essential elements (Ag, Al, Cd, Pb, Ni), were detected and quantified in the crude sample of each species. Cd, Co, Fe, and Na were most extracted (82.5, 64.3, 89.8, and 55.6 % respectively) by infusion in P. muellerianus; Mg by infusion (41.3 %), and Cd by decoction (37.1 %) in O. dactylophylla; as well as Se and Co by infusion (74.6 and 55.4 % respectively) in S. longepedunculata. Mineral elements daily intake trough the studied extracts decreased in order P. muellerianus > S. longepedunculata > O. dactyllophylla, reflecting the mineral content of their crude drugs, and showing the dangerousness of P. muellerianus, known to bioaccumulate harmful minerals including Cd and Pb. Target hazard quotients (HTQ) were > 1 for Al, Cd and Pb, multiplying the non-carcinogenic toxic hazard index (HI) by 40, 22, and 32 respectively for infused, decocted and 24 h macerated P. muellerianus. However, the carcinogenic risk was significantly negligible (CR < 0.0001) for extracts of all the analyzed species.

Conclusion

Ingestion of 367 mL of O. dactyllophylla root bark aqueous extracts would be harmless, whereas extraction on the same samples of S. longepedunculata and P. muellerianus should preferably be 2 to 12 h maceration.
尽管卢本巴希地区药用植物中含有大量有害矿物元素,但迄今为止还没有关于卢本巴希药用植物中矿物元素可提取性的研究报道。本研究评估(i)卢本巴希最常用的3种药用植物根皮水提取物中矿物元素的可提取性,(ii)有害矿物元素的生物可及性对健康的风险。方法:采用长叶古菲尔根皮粉末。采自卢本巴希地区3个地点的J. lsamuonard、Phyllanthus muellerianus (Kuntze) Exell和Securidaca longepedunculata Fresen,分别浸泡(2 h、6 h、12 h和24 h)、浸渍和蒸馏水煎煮。用电感耦合等离子体原子发射光谱分析了萃取物、相应的粗样品(粉末)和所用溶剂。结果各物种粗样中均检出4种常量元素(Ca、K、Na、Mg), 6种微量元素(Co、Cu、Fe、Mn、Zn、Se)和5种非必需元素(Ag、Al、Cd、Pb、Ni)。Cd、Co、Fe和Na的浸出率最高,分别为82.5%、64.3%、89.8和55.6%;紫苏中Mg滴注(41.3%)、Cd煎煮(37.1%);Se和Co的含量分别为74.6%和55.4%。通过所研究的提取物每日矿物质元素摄取量依次递减,这反映了其药材中矿物质的含量,同时也显示了其具有生物积累Cd、Pb等有害矿物质的危险性。Al、Cd和Pb的靶危险系数(HTQ)为1,与注药、煎煮和浸泡24 h的非致癌性毒性系数(HI)分别乘以40、22和32。然而,所有被分析物种的提取物的致癌风险明显可以忽略不计(CR < 0.0001)。结论短叶黄皮水提液367 mL对人体无害,而长叶黄皮和细叶黄皮水提液浸泡2 ~ 12 h对人体无害。
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引用次数: 0
Anti-anemic potential of cerium oxide nanoparticles in diet-induced obese rats: Role of hepcidin, oxidative stress, and inflammation 氧化铈纳米颗粒在饮食诱导的肥胖大鼠中的抗贫血潜力:hepcidin,氧化应激和炎症的作用
Pub Date : 2025-08-24 DOI: 10.1016/j.jtemin.2025.100260
Samir A.E. Bashandy , Marawan A. Elbaset , Fatma A.A. Ibrahim , Sherif A. Abdelmottaleb Moussa , Noha A. Abd El-Latif , Sherif M. Afifi , Tuba Esatbeyoglu , Ahmed M.A. El-Seidy

Background

Obesity and overweight result in low-grade systemic inflammation associated with an increase of oxidative stress and hepcidin discharging and lowering iron absorption giving rise to anemia. This study is aimed to investigate the anti-anemic effect of cerium oxide nanoparticles (CeO2NPs) in obese rats via investigation of hepcidin expression, ferritin, inflammatory markers, and oxidative stress parameters

Methods

CeO2NPs were synthesized using sol–gel method. Eight male rats were specified as control non-obese. Twenty-four Wistar adult male rats were subjected to high fat diet /sucrose and they were divided into 3 groups; obese, 15 or 30 mg.kg−1 CeO2NPs IP treatment for the subsequent 8 weeks. Blood cell counts, hepicidin gene expression in adipose tissue, inflammatory and oxidative stress parameters beside iron parameters were evaluated in the experimental groups.

Results

CeO2NPs crystallite size is 48.88 nm. The ratio of Ce4+ was 69.33 %. The intraperitoneal injection of obese rats with CeO2NPs substantially reduced the elevetion in WBCs, platelets count, plasma cholesterol, triglycerides, malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α (Tumor necrosis factor alpha), IL-6 (Interleukin-6), and CRP (C-reactive protein) levels. Also, CeO2NPs combate the increase of hepcidin gene expression, ferritin level, iron content in adipose tissue, body weight, body mass index (BMI) and plasma leptin concentration of obese rats. Moreover, RBCs and WBCs count, Hb level, adiponectin level, and reduced glutathione (GSH) were enhanced in obese rats given CeO2NPs.

Conclusion

CeO2NPs may have anti-anemic activity in obese rats via management of hepcidin gene expression along with antioxidant and anti-inflammatory properties.
背景:肥胖和超重导致低度全身性炎症,与氧化应激和hepcidin释放和降低铁吸收的增加有关,从而导致贫血。本研究旨在通过研究氧化铈纳米颗粒(CeO2NPs)对肥胖大鼠hepcidin表达、铁蛋白、炎症标志物和氧化应激参数的影响,探讨其抗贫血作用。8只雄性大鼠被指定为对照非肥胖。取24只Wistar成年雄性大鼠饲喂高脂/蔗糖饲料,随机分为3组;15或30 mg.kg - 1 CeO2NPs IP治疗,随后8周。测定各组小鼠血细胞计数、脂肪组织hepicidin基因表达、炎症和氧化应激参数及铁参数。结果sceo2nps晶粒尺寸为48.88 nm。Ce4+的含量为69.33%。腹腔注射CeO2NPs可显著降低肥胖大鼠白细胞、血小板计数、血浆胆固醇、甘油三酯、丙二醛(MDA)、超氧化物歧化酶(SOD)、TNF-α(肿瘤坏死因子α)、IL-6(白细胞介素-6)和CRP (c反应蛋白)水平的升高。此外,CeO2NPs还能抑制肥胖大鼠hepcidin基因表达、铁蛋白水平、脂肪组织铁含量、体重、体重指数(BMI)和血浆瘦素浓度的升高。此外,给予CeO2NPs的肥胖大鼠红细胞和白细胞计数、Hb水平、脂联素水平和还原谷胱甘肽(GSH)水平均升高。结论ceo2nps可能通过调控hepcidin基因表达及抗氧化和抗炎作用,在肥胖大鼠中具有抗贫血活性。
{"title":"Anti-anemic potential of cerium oxide nanoparticles in diet-induced obese rats: Role of hepcidin, oxidative stress, and inflammation","authors":"Samir A.E. Bashandy ,&nbsp;Marawan A. Elbaset ,&nbsp;Fatma A.A. Ibrahim ,&nbsp;Sherif A. Abdelmottaleb Moussa ,&nbsp;Noha A. Abd El-Latif ,&nbsp;Sherif M. Afifi ,&nbsp;Tuba Esatbeyoglu ,&nbsp;Ahmed M.A. El-Seidy","doi":"10.1016/j.jtemin.2025.100260","DOIUrl":"10.1016/j.jtemin.2025.100260","url":null,"abstract":"<div><h3>Background</h3><div>Obesity and overweight result in low-grade systemic inflammation associated with an increase of oxidative stress and hepcidin discharging and lowering iron absorption giving rise to anemia. This study is aimed to investigate the anti-anemic effect of cerium oxide nanoparticles (CeO<sub>2</sub>NPs) in obese rats via investigation of hepcidin expression, ferritin, inflammatory markers, and oxidative stress parameters</div></div><div><h3>Methods</h3><div>CeO<sub>2</sub>NPs were synthesized using sol–gel method. Eight male rats were specified as control non-obese. Twenty-four Wistar adult male rats were subjected to high fat diet /sucrose and they were divided into 3 groups; obese, 15 or 30 mg.kg<sup>−1</sup> CeO<sub>2</sub>NPs IP treatment for the subsequent 8 weeks. Blood cell counts, hepicidin gene expression in adipose tissue, inflammatory and oxidative stress parameters beside iron parameters were evaluated in the experimental groups.</div></div><div><h3>Results</h3><div>CeO<sub>2</sub>NPs crystallite size is 48.88 nm. The ratio of Ce<sup>4+</sup> was 69.33 %. The intraperitoneal injection of obese rats with CeO<sub>2</sub>NPs substantially reduced the elevetion in WBCs, platelets count, plasma cholesterol, triglycerides, malondialdehyde (MDA), superoxide dismutase (SOD), TNF-α (Tumor necrosis factor alpha), IL-6 (Interleukin-6), and CRP (C-reactive protein) levels. Also, CeO<sub>2</sub>NPs combate the increase of hepcidin gene expression, ferritin level, iron content in adipose tissue, body weight, body mass index (BMI) and plasma leptin concentration of obese rats. Moreover, RBCs and WBCs count, Hb level, adiponectin level, and reduced glutathione (GSH) were enhanced in obese rats given CeO<sub>2</sub>NPs.</div></div><div><h3>Conclusion</h3><div>CeO<sub>2</sub>NPs may have anti-anemic activity in obese rats via management of hepcidin gene expression along with antioxidant and anti-inflammatory properties.</div></div>","PeriodicalId":73997,"journal":{"name":"Journal of trace elements and minerals","volume":"14 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global lead contamination in soils, sediments, and aqueous environments: Exposure, toxicity, and remediation 全球土壤、沉积物和水环境中的铅污染:暴露、毒性和修复
Pub Date : 2025-08-08 DOI: 10.1016/j.jtemin.2025.100259
Pratibha Mishra , Shakir Ali , Rakesh Kumar , Shashank Shekhar

Background

Lead (Pb) is a heavy meta(loid) and historically been used in paints, jewelleries, electronics, soldering, plumbing, and cookware due to its high malleability, low melting point, resistance to corrosion, and ability to bond with other metals. However, Pb is recognized as one of the toxic elements commonly occurring in soils, sediments, and natural water.

Objectives and methods

This article provides a comprehensive review of the current status of Pb contamination, underscoring its distribution, persistence, fate, and impacts on humans and plants. We investigated recent literature focusing on: (a) sources of Pb contamination in soils, sediments, and aqueous environments, (b) lead mobilization, occurrences, toxicity mechanisms, and their potential health effects; and (c) various remediation methods for Pb contamination in soil and water. Additionally, case studies from the USA, China, and India on Pb sources and pollution in different ecosystems are discussed.

Results

Our findings indicate that: 1) Lead concentrations exceed permissible limits in numerous soils, sediments, and water globally, while remediation efforts remain largely localized and limited in scale. 2) The mobility of Pb facilitates its bioaccumulation, enabling it to substitute for Ca²⁺ as a signalling messenger in plants and animals. This results in adverse effects such as impaired germination and nutrient uptake in plants, as well as neurotoxicity and other cascading negative impacts in humans and animals.

Conclusion

The study reveals that soils, sediments, and aqueous environments are moderately to highly polluted with Pb, necessitating further investigation into its mobilization and toxicity. Therefore, this contaminant should be comprehensively studied and mitigated through appropriate policy interventions.
铅(Pb)是一种重金属(loid),由于其高延展性,低熔点,耐腐蚀性和与其他金属结合的能力,历史上被用于油漆,珠宝,电子,焊接,管道和炊具。然而,铅被认为是土壤、沉积物和天然水中常见的有毒元素之一。目的与方法本文综述了铅污染的现状,重点介绍了铅污染的分布、持久性、命运及其对人类和植物的影响。我们调查了最近的文献,重点是:(a)土壤、沉积物和水环境中铅污染的来源;(b)铅的迁移、发生、毒性机制及其潜在的健康影响;(c)土壤和水中铅污染的各种修复方法。此外,还讨论了美国、中国和印度在不同生态系统中铅来源和污染的案例研究。结果:1)全球许多土壤、沉积物和水中的铅浓度都超过了允许的限度,而修复工作在很大程度上仍然是局部的,规模有限。2) Pb的迁移性促进了它的生物积累,使其能够替代Ca 2 +在植物和动物中作为信号信使。这会导致不良影响,如植物发芽和营养吸收受损,以及对人类和动物的神经毒性和其他级联负面影响。结论土壤、沉积物和水环境中存在中度至重度铅污染,需要进一步研究其迁移和毒性。因此,应全面研究这种污染物,并通过适当的政策干预加以缓解。
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引用次数: 0
Interactive effect of copper and nickel on juveniles of tambaqui (Colossoma macropomum) exposed to pH 4 and pH 7 铜和镍对暴露于pH 4和pH 7环境下的大鲵幼鱼的交互作用
Pub Date : 2025-08-05 DOI: 10.1016/j.jtemin.2025.100257
Priscylla M. Pavione, Adalberto L. Val
Copper (Cu) and nickel (Ni) are common in natural waters and can be toxic to fish, including those in the Amazon. The objective of this study is to assess the impact of copper (Cu) and nickel (Ni) on the biochemical and physiological characteristics of juvenile Colossoma macropomum. The study exposed 64 animals to varying concentrations of Cu and Ni, as well as a mixture of both metals, at pH levels of 4 and 7 for 96 h. The results demonstrated that pH levels significantly impacted several biological markers, including hemoglobin, catalase, lipoperoxidation (LPO), superoxide dismutase (SOD), and acetylcholinesterase (AChE). In particular, pH 7 was found to increase LPO and catalase levels while decreasing SOD and AChE levels. Notably, the study identified an inverse relationship between LPO levels and AChE activities. Exposure to Cu and Cu+Ni mix resulted in the inhibition of H+-ATPase activity at pH 4. At pH 4, Cu and Cu+Ni mix also inhibited Na+/K+-ATPase activity, while at pH 7, Ni and Cu+Ni mix inhibited it. The antagonistic effect of Ni and Cu on Na+/K+-ATPase was confirmed in animals exposed to a Cu+Ni mix. In all experimental conditions, superoxide dismutase (SOD) activities exhibited an increase at pH 4, which was followed by a decrease in lipid peroxidation (LPO). The effects of metals on SOD, LPO, and ACHE were found to be offset by changes in water pH.
铜(Cu)和镍(Ni)在自然水域中很常见,可能对鱼类有毒,包括亚马逊河流域的鱼类。本研究旨在探讨铜(Cu)和镍(Ni)对巨像幼鱼生理生化特性的影响。该研究将64只动物暴露在不同浓度的Cu和Ni以及两种金属的混合物中,pH值为4和7,持续96小时。结果表明,pH值显著影响了几种生物标志物,包括血红蛋白、过氧化氢酶、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)和乙酰胆碱酯酶(AChE)。pH 7增加了LPO和过氧化氢酶水平,降低了SOD和AChE水平。值得注意的是,该研究确定了LPO水平与AChE活性之间的反比关系。暴露于Cu和Cu+Ni混合物中导致pH为4时H+- atp酶活性受到抑制。在pH为4时,Cu和Cu+Ni混合对Na+/K+- atp酶活性也有抑制作用,而在pH为7时,Ni和Cu+Ni混合对Na+/K+- atp酶活性有抑制作用。在暴露于Cu+Ni混合物的动物中证实了Ni和Cu对Na+/K+- atp酶的拮抗作用。在所有实验条件下,pH为4时,超氧化物歧化酶(SOD)活性升高,随后脂质过氧化(LPO)降低。发现金属对SOD、LPO和ACHE的影响被水pH的变化所抵消。
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引用次数: 0
Assessment of pond water quality and human health risk in the shoreline, intermediate and inland coastal areas of Bangladesh 评估孟加拉国海岸线、中部和内陆沿海地区的池塘水质和人类健康风险
Pub Date : 2025-07-12 DOI: 10.1016/j.jtemin.2025.100256
Md. Shohel Khan , Shitangsu Kumar Paul

Introduction

Surface water quality of the southwestern coastal zones of Bangladesh has been deteriorating through different human, industrial and agricultural activities. The emission of the effluents containing trace metals from these activities can contaminate the surface water. Human health may be adversely affected through the intake of trace metals present in drinking water.

Objectives

The study assessed pond water quality and human health risk in three villages named shoreline (Rajoir), intermediate (Gangarampur) and inland (Ganapatipur) of southwest coastal Bangladesh. A total of 36 water samples were collected from randomly selected 12 stations covering almost the entire study area. A total of 18 parameters were tested to determine the quality through water quality index (WQI), metal evaluation index (MEI), metal pollution index (MPI), and hazard index (HI). In addition, a total of 338 household heads (HHs) were interviewed through a self-developed semi-structured questionnaire along with three focus group discussions (FGDs) to achieve the objectives.

Results

The mean WQI increased from 105.95–150.69 from the shoreline to the inland area and was graded as ‘unsuitable’. The mean MEI was higher in the intermediate than that of shoreline and inland areas. The mean HIchild was also higher than HIinfant and HIadult in the three study areas, indicating that children were at higher risk rather than other. The MEI results indicated that about 50 % of water samples were graded as ‘moderately affected’ for all the study area. According to MPI, about 75 % (inland) and 50 % (shoreline) water samples were graded as ‘moderately affected’. HI recommended that all the sampling stations were graded as ‘unsafe’ except 25 % of samples from both shoreline and intermediate areas for infants. The majority of the respondents reported suffering from various diseases.

Conclusion

Pond water is recommended for use in drinking or household purposes only after proper filtration. Furthermore, the research findings are important for environmental and human health. Further research would be beneficial to explore the link among water pollution, human health, and livelihoods, and to understand the extent of pollution. This study also serves as a baseline for the coastal area of Bangladesh.
由于不同的人类、工业和农业活动,孟加拉国西南沿海地区的地表水质量一直在恶化。这些活动排放的含有微量金属的废水会污染地表水。人体健康可能因摄入饮用水中的微量金属而受到不利影响。目的对孟加拉国西南沿海3个村庄的池塘水质和人类健康风险进行评估,这些村庄分别为海岸线村(Rajoir)、中间村(Gangarampur)和内陆村(Ganapatipur)。从随机选择的12个站点采集了36个水样,几乎覆盖了整个研究区域。通过水质指数(WQI)、金属评价指数(MEI)、金属污染指数(MPI)和危害指数(HI)共测试18个参数来确定水质。此外,通过自行编制的半结构化问卷和三次焦点小组讨论,对338名户主进行了访谈,以实现目标。结果滨海至内陆地区的平均WQI为105.95 ~ 150.69,为“不适宜”。中部地区的平均MEI指数高于沿海和内陆地区。在三个研究区域中,平均HIchild也高于HIinfant和HIadult,表明儿童的风险高于其他儿童。MEI结果表明,在所有研究区域,约50%的水样被评为“中度受影响”。根据MPI,大约75%(内陆)和50%(海岸线)的水样被评为“中度受影响”。国际卫生组织建议,除了海岸线和中间地区25%的婴儿样本外,所有采样站都被评为“不安全”。大多数答复者报告患有各种疾病。结论池水应经适当过滤后,方可饮用或家庭使用。此外,研究结果对环境和人类健康具有重要意义。进一步的研究将有助于探索水污染与人类健康和生计之间的联系,并了解污染的程度。这项研究也可以作为孟加拉国沿海地区的基线。
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引用次数: 0
期刊
Journal of trace elements and minerals
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