Annals of Tropical Medicine and Public Health最新文献

{"title":"Sphingosine -1- phosphate receptor 1 polymorphism as a cause of Fingolimod unresponsiveness and Multiple Sclerosis initiation","authors":"A. H. Khaliel, A. Abbas, A. Hatem, A. Abdulamir","doi":"10.36295/ASRO.2021.24204","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24204","url":null,"abstract":"Background: Alot of immune cells have sphingosine -1phosphate receptor (SIPR) which regulates its migration from lymph node to blood circulation. The SIPR polymorphisms have been the focus the focus of some studies as genetic risk factor for multiple sclerosis and drug responsiveness. Aim: This study was aimed to show if the genetic variations of the S1P1 have a role in Fingolimod/Gilenya (FTY720) unresponsiveness and if S1P1polymorphisms were considered as genetic predisposition factor for MS. Materials and methods: This Case control study involved; sixty-six (66) with multiple sclerosis (MS), their ages were range from 14 to 69 years. They attended to seek treatment in the MS out patient’s clinic at Medical CityBaghdad Teaching Hospital in the period, which extended from December 2018 to March 2020. Patient was divided into two group resistant group (34) and response group (32) to fingolimod (Gelyinia) treatment. Results: The SIPR 1 gene sequencing revealed two SNPs rs3737577andrs3737578without significant differences between control group and patients, responder patients and non-responder patients on the level of genotype and allele frequency. A comparison between responsive and resistant patients revealed that the haplotype block TT was more frequent among nonresponder patients (30.88%) than responder patients (15.63%) with a significant difference (OR= 2.41, 95%CI=1.03-5.64, p= 0.042). Conclusion: There is no relationship between SIPR1 gene polymorphismand the responsiveness to the fingolimod in MS patients, but the TT haplotype block in this gene may have a negative effect on response to that medication also this gene polymorphisms cannot considered as genetic risk factor for MS initiation. Keyword: Multiple Sclerosis, SIPR1 and Fingolimod (Gelyinia) How to cite this article: Khaliel AH, Abbas AA-H, et al (2021): Sphingosine-1 phosphate receptor 1 polymorphism as a cause of fingolimod unresponsiveness and multiple sclerosis initiation, Ann Trop Med & Public Health; 24(S2): SP24204. DOI: http://doi.org/10.36295/ASRO.2021.24204 Introduction Multiple sclerosis (MS) is a chronic, inflammatory immune-mediated, neurodegenerative disorder. It is the leading nontraumatic cause of disability in young adults and affect three times women than men (1,2) .The deep heterogeneity of MS is not restricted to the symptoms, but to histologic appearances of lesions, neuroradiologic and response to therapy (3) Over the past two decades, different novel disease-modifying drugs for multiple sclerosis (MS) have been approved. However, there are high differences in the patient response to the available medications, which is hypothesized to be partly attributed to genetics (4) . Sphingosine-1-phosphate (S1P) is a normal bioactive lipid molecule and a commonfirst Khaliel et al (2021): Genetic variation of S1P1 in FTY720 and MS Feb 2021 Vol. 24 Issue 2 Annals of Tropical Medicine & Public Health http://doi.org/10.36295/ASRO.2021.24204 or second messenger in the immune","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84242440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NURSES’ SPIRITUAL DISTRESS DURING END OF LIFE DECISION MAKING: A PHENOMENOLOGICAL STUDY","authors":"A. Hidayat, W. Kongsuwan, K. Nilmanat, A. S. Siwi","doi":"10.36295/ASRO.2021.24307","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24307","url":null,"abstract":"Objectives: This study describes the meaning of Muslim nurses ’ lived experience during their involvement in End of Life (EOL) decision making in Intensive Care Unit (ICU) Methods: This study was conducted in an ICU of a government hospital in Central Java, Indonesia. Fourteen nurses were recruited as participants after they met the inclusion criteria: Muslims, working at least three years in the ICU, and willing to share their experience. Data were collected using in-depth interviews. Van Manen's hermeneutic phenomenological approach was used to analyze the data transcription. Results: Experiences of nurses' involvement in EOL decision making revealed four thematic categories. Feeling spiritual distress, understanding family’s feelings as a killer, respecting privacy, and continuing time of caring. These themes reflecting van Manen's four lived world of body, time, relation, and space. Conclusions: This study described the meaning of Muslim nurses ’ EOL decision making in ICU and influence nursing policies regarding education in EOL decision making in ICU settings.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77029870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of Paramedical staff regarding Autism in Al-Najaf governorate, Iraq","authors":"G. Talib, A. A. Al-Sarray","doi":"10.36295/ASRO.2021.24234","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24234","url":null,"abstract":"Autism is a life-long neurodevelopmental condition interfering with the person’s ability to communicate and relate to others. It appears to be one of the fastest growing disabilities in children. To determine the level of knowledge of Paramedical staff regarding Autism in Al-Najaf governorate. A descriptive; cross sectional study conducted at 30 randomly selected (multistage sample) hospitals and primary health care centers in Al-Najaf governorate, included 464Paramedical staff, The data collection continued for the period starting on 12 th December-2019 ending on 7 th March, 2020. The results of demographic data was conducted on Paramedical staff with their mean age (32.2±10.6) years ranging from (20-59) years and the highest percentage (55.2%) were in the age group (20-29) years and the lowest percentage(11.2) were in the age group (50---59) years, most of studied sample were females (66.3%) and married (66.2%),regarding period of experiencethe highest percentage (46.3%) with period of experience (1-4) years, while regarding the residence the majority of the studied sample (80.6%) from urban area.Regarding educational level highest percentage (58.6%) from medical institute. And lowest percentage (11.4) from collage and above. With regard to the professional level the highest percentage (48.3 %) from nurse, and the lowest percentage (4.1%) from medical technical college graduates. While regarding the health institution the highest percentage (80.0%) from primary health care centers, and the low percentage (20.0%) from hospitals, according to their family member with autism and training courses, the highest percentage (95.7%) of the paramedical staff who do not have a member with autism, while regarding the training courses the majority of the studied sample (92.2%) had not entered training courses.Their knowledge was mainly gained from Internet, friends and health workers. In conclusion,this study concluded that the paramedical staff had fair and acceptable knowledge regarding Autism in Al-Najaf governorate during the period of study. National education programs on autism are needed to be presented to the public through cooperation between health authorities, society organizations and non-governmental organization.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80974847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capacity Building of Village Health Cadres in Community-Based Disaster Risk Reduction in Volcanic Disaster Prone Areas of Banyumas Regency","authors":"Ridlwan Kamaluddin, Eva Rahayu","doi":"10.36295/ASRO.2021.24351","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24351","url":null,"abstract":"Objective : This study aims to evaluate the training to increase village health cadres capacity in areas which prone to volcanic eruptions in Banyumas regency. Methods : This research used quasi eksperiment non equivalent pre and post test group with control design . The population in this study is the village health volunteers in disaster-prone areas of Mount Slamet as many as 9 villages. The sample in thiswere 32 people for the intervention group and 32 controls. Results : The results of this research is the increased knowledge (p <0.05), and the skills of village health cadres (p<0.05) regarding disaster risk reduction. Conclusions : Disaster preparedness training for village health cadres could improve the knowledge and skills of cadres in disaster risk reduction. Village health cadres has endure difficult task and duty, so special health cadres in disaster risk reduction, called cadres of disaster preparedness (KASTANA) is needed.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87694837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Professionalism of Physical Education Teachers in Bali Province by Using a Lesson Study Model based on Balinese Local Wisdom","authors":"M. A. Wijaya, I. Kanca, I. Yoda, I. K. I. Swadesi, Rifqi Festiawan","doi":"10.36295/ASRO.2021.24332","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24332","url":null,"abstract":"Introduction: Balinese Local Wisdom includes Tri Hita Karana (a harmonious relationship between God Humans Environment), Tri Kaya Parisudha (thinking, saying and doing good) and traditional Balinese games . Objective: This study aims to develop a lesson study model based on Balinese local wisdom in increasing the professionalism of Physical Education (PE) teachers inbasiceducationin Bali. Method: This research development employs the Fenrich model, includes6 phases, namely: 1) analysis;2) planning; 3) design;4) development; 5) implementation; and6) evaluation and revision. This article focuses on the implementation phase. The study was conducted in four elementary and junior high schools that took place in Badung regency, Buleleng regency, Jembrana regency, Karangasem regency, and Klungkung regency. Data collection techniques used were: PE class observation sheet, Formative Class Evaluation (FCE) questionnaire and the analysis of the focus learning. The data were analyzed descriptively. Results: The results showed:1) the PE teacher's activities in providing motion task, feedback and evaluation were carried out as much as 55.71% in the core learning activities, 2) the active time allotment provided by the PE teacher was in the average of 73 minutes of 120 minutes from learning time, 3) the number of student's direct engagement was 85.0%, and 4) the average FCE score was 2.82 from a maximum score of 3.00. Conclusion: Based on the data analysis and discussion, it can be concluded that a lesson study model based on Balinese local wisdom was very well implemented and was able to improve the professionalism of PE teachers inbasiceducation in Bali province.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82743036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of the Development of Rhythmic Activity Model of the Barongan Dance Modification for Physical Education Learning In Primary School","authors":"Yudha Febrianta, P. Sukoco, F. Sugiyanto, Rifqi Festiawan","doi":"10.36295/ASRO.2021.24305","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24305","url":null,"abstract":"Objectives: This study aims to produce a rhythmic activity model by modifying barongan dance in Physical Education learning in primary schools. Method: This is a research adapted by Borg & Galls research steps consisting of ten steps of conducting research as follows: (1) gathering information, (2) planning the products to be created, (3) preparing initial product drafts, (4) having small-scale trials, (5) revising product, (6) having large-scale trials, (7) revising product, (8) testing the effectiveness, (9) revising final product, (10) disseminating the products. Small-scale field trials were conducted at the two Primary School. Large-scale field trials were conducted at four Primary School. The instruments used to collect data are observations, interviews, evaluation sheets of effectiveness tests including evaluation of learning outcomes, consisting of cognitive, affective, psychomotor evaluation. The validity of the cognitive validity evaluation instrument is 0.631 with the reliability of 0.836. Meanwhile the evaluation of affective validity is 0.679 with reliability of 0.700, and the evaluation of psychomotor validity is 0.648 with the reliability of 0.824. The data analysis technique used is quantitative descriptive analysis and normality test analysis, homogeneit y test, and t test. Result: The product of rhythmic activity model development, which is the result of this research, was done by modifying barongan dance in physical education learning for the high -grade students in primary schools. This product is found to be very effective. Conclusions: The rhythmic activity in barongan dance modification in Physical Education learning contributed 11.03% for cognitive aspects, 12.06% for affective aspects, and 13.60% for psychomotor aspects.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88544877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence of Metabolic Syndrome among University Workers and Its Relationship with The Anthropometric Parameters","authors":"Yovita Puri Subardjo, F. C. Agustia, Dika Betaditya, G. R. Ramadhan, Noor Cherinawati","doi":"10.36295/ASRO.2021.24331","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24331","url":null,"abstract":"Background: Metabolic syndrome parameters can predict the development of metabolic diseases, such as diabetes mellitus type 2 and cardiovascular diseases. Workers have a higher risk of suffering from the metabolic syndrome due to their less physical activities as well as high carbohydrate and fat consumptions. For routine health control, the metabolic syndrome diagnoses are known less practical and more costly than the anthropometric measurements . Objectives: This study aims at obtaining the prevalence of metabolic syndrome among workers and finding the most related anthropometric parameter to metabolic syndrome. Methods: 80 research subjects were collected to participate in a cross -sectional study measured us ing the anthropometric parameters and metabolic syndrome components to obtain the relationship of anthropometric parameters with metabolic syndrome components using the Pearson-Spearman analysis as well as the multivariate analysis. Results: The results showed that the prevalence of metabolic syndrome among workers was 31.25%. The increasing anthropometric variable values also indicate the increasing metabolic syndrome components as follows: waist -to-hip ratio to triglyceride level; abdominal circumference to blood pressure; body mass index to triglyceride level and abdominal circumference; body fat percentage to abdominal circumference and fasting blood sugar. The interaction between body fat percentage and mid-upper arm circumference increased the triglyceride level by 13%. The interaction between waist-to-hip ratio and body mass index increased the abdominal circumference by 81%. Conclusions: The increasing anthropometric parameters can be used to assess the increasing value of metabolic syndrome components.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91072921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Branched Chain Amino Acid and Glycine in Prediabetes and Type II Diabetes Mellitus","authors":"Israa Abass Rasheed, E. Alwasiti, I. Al-Karawi","doi":"10.36295/ASRO.2021.24223","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24223","url":null,"abstract":"2 National Diabetes center, Mustansiriyah University, Iraq *Corresponding author: Israaalhelo2@gmail.com (Rasheed) Abstract “Prediabetes is the term used for people whose glucose levels do not meet the diabetes criteria but is too high to be considered normal. Prediabetes patients should not be regarded as a clinical entity in their own right, but rather as an increased risk of diabetes and cardiovascular disease (CVD) ,It is linked to obesity (especially abdominal or visceral obesity), high triglyceride dyslipidemia and/or low HDL cholesterol, and hypertension. Branched-chain amino acids (BCAAs) are essential amino acids that include Valine, Leucine, and isoleucine, glycine is non-essential amino acids. Recent studied show that (BCAA) increased positively with insulin resistance and glycine work inversely this make a predictive for Type 2 DM. the present study show a higher significance increase of BCAA in prediabetes patients compared to control and lower significance decrease of glycine in prediabetes compared to control. In conclusion Amino acid and glucose metabolism are closely linked; amino acids represent a main reservoir for gluconeogenesis and influence insulin and glucagon secretion. Both processes are altered early in the pathogenesis of T2D, which, at least in theory, makes amino acids good candidates for biomarkers in this area.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89623902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing Knowledge and Students Attitude Through Health Education on Bullying","authors":"Mikawati, Evi Lusiana, Sitti Syamsiah, Hasriany, Nisaul Magfirah","doi":"10.36295/ASRO.2021.24318","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24318","url":null,"abstract":"Background: Bullying is defined as an act by using power to hurt a person or group of people verbally, physically, and psychologically so that the victim feels depressed, traumatized, and helpless. Children and adolescents falling victim to bullying are more at risk of health problems, both physically and mentally. This Study aimed to find out the effect of bullying health education on students' knowledge and attitudes about bullying in elementary school. Material and Methods: This study is an experimental research with pre-experimental design research method without using control group. Respondents were the sixgrade students at the Aroepala State Elementary School who were enrolled and actively participated in the study for at least 6 months as many as 60 people. A data analysis method using Wilcoxon Signed-Rank Test, to examine scores from two samples couple and nonstandard distribution data, namely pre-test and post-test in experiment group. Result: Results show that bullying health education by the group method can improve students' knowledge and attitude about bullying (p=0.000). Conclusion: It is recommended that schools should have local content on bullying materials integrated into subjects so as to improve students' understanding of bullying behavior.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78164968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Bladder Cancer at early age in Iraq used by Tumor Marker and Genes Characterization","authors":"Hayder Hatem Abdulwahhab, M. Dölarslan, M. Marjani","doi":"10.36295/ASRO.2021.24212","DOIUrl":"https://doi.org/10.36295/ASRO.2021.24212","url":null,"abstract":"Cancer is mostly considered as a 30 % genetic disease so much so that this disease, which defines a multi-step neoplasia characterized by tumor formation and cell proliferation becomes uncontrolled, depends on the individual's genetic predisposition.Bladder tumors are clinically characterized by their high recurrence rate once they invade the muscle layerwhich added clinical value as diagnostic and prognostic biomarkers in bladder cancer. Progress of the high-impact technologies for molecular analysis of tumors allow explore genetic profiles, epigenetic and protein characteristic different tumor subtypes and identify targets and molecular pathways that define a specific clinical behavior. Objective to evaluate the Bladder Tumor Marker (BTM) as a new developed tumor marker in comparison to cytology in the selected area.The present study contributes to a growing body of work on gene expression signatures in bladder cancer and urine samples collection from Bladder cancer early detection center at Nineveh health department, Al-khansa Teaching Hospital in Mosul during the study period patients N: 101 and controls N: 19 .The final study is to establish a concept of stratification of patients with bladder cancer. For this, we have developed a multi-parameter test for the quantification of the selected biomarkers.","PeriodicalId":7958,"journal":{"name":"Annals of Tropical Medicine and Public Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78370735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}