This study introduces a new type of cantilever-probe system that extends atomic force microscopy to high-load, large-contact-area measurements, supporting friction studies from nano to millimeter scales. By using polymer cantilevers with colloidal microspheres, this customizable probe system (8–25 N/m cantilever stiffness; 0.08–2.5 mm probe radius) allows friction measurements on single-crystal MoS₂ under loads of 0.5–120 μN, contact areas of 0.02–10 μm2, and contact pressures from 2 to 150 MPa, bridging nanoscale and microscale observations. Our findings reveal a novel scale effect, where the friction coefficient increases by a factor of 34 with a 30-fold increase in probe radius. This affordable alternative to commercial cantilevers also simplifies calibration and enhances accessibility for tribological studies in nanocomposites, MEMS/NEMS, and biological materials, offering a scalable tool for cross-scale friction research.