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Synergies Between Observed Warming and ENSO Episodes on Extreme Events 观测到的变暖和ENSO事件对极端事件的协同作用。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-04 DOI: 10.1111/nyas.70122
Francisco Estrada, Pierre Perron, Yohei Yamamoto

El Niño/Southern Oscillation (ENSO) is the dominant interannual variability mode of the global climate system with significant effects on a variety of weather conditions, including extremes. Past events illustrate the severe societal consequences this phenomenon has through weather disasters, food security, health, economic growth, migration, and conflict. ENSO's interactions with global warming are not well understood, although they can lead to significant changes in the characteristics of extreme events. Climate conditions in 2024/2025 may favor widespread severe extreme events with global temperature anomalies nearing or surpassing 1.5°C and a transition from strong El Niño to La Niña conditions. Here, we show that current warming has amplified the effects of ENSO on temperature and precipitation extremes worldwide. Results show that warming has produced a considerable amplification of the effects of ENSO episodes over such extremes, as well as extensively modified spatial patterns. We show that considerable shares of the population, gross domestic product, agriculture, and ecosystems now face a higher risk from extreme events due to the interactions between increased anthropogenic forcing and ENSO.

El Niño/南方涛动(ENSO)是全球气候系统的主要年际变率模态,对包括极端天气在内的各种天气条件具有重要影响。过去的事件表明,这一现象通过天气灾害、粮食安全、健康、经济增长、移民和冲突造成了严重的社会后果。ENSO与全球变暖的相互作用尚不清楚,尽管它们可以导致极端事件特征的重大变化。2024/2025年的气候条件可能有利于广泛的严重极端事件,全球温度异常接近或超过1.5°C,并从强El Niño向La Niña过渡。在这里,我们表明当前的变暖放大了ENSO对全球极端温度和降水的影响。结果表明,气候变暖使ENSO事件对这些极端事件的影响大大放大,并使空间格局发生了广泛的改变。我们表明,由于人为强迫和ENSO之间的相互作用,相当大一部分人口、国内生产总值、农业和生态系统现在面临着来自极端事件的更高风险。
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引用次数: 0
National Adoption of World Health Organization Recommendations on Calcium Supplementation During Pregnancy 全国采纳世界卫生组织关于怀孕期间补钙的建议。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-03 DOI: 10.1111/nyas.70120
Iris B. Romero, María Bernardita Puchulu, Surya M. Perez, Cintia White, Ziaul Hasan Rana, Megan W. Bourassa, Camila Delgado, José M. Belizán, Florencia Salva, Gabriela Cormick

In several countries, pregnant women have suboptimal intakes of calcium and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy reduces the risk of these disorders and is recommended for pregnant women with low dietary calcium intake to prevent preeclampsia. Our objective was to evaluate the global adoption of the World Health Organization (WHO) recommendation for calcium supplementation during pregnancy to prevent pre-eclampsia. Each WHO member state's Ministry of Health website, Google, and WHO databases were searched, between January and July 2024, to identify national antenatal care guidelines. We found pregnancy-related guidelines published between 2007 and 2024 in 92 countries of the 194 countries included in this review (47.4%), of which 58 (63%) included calcium intake recommendations, and 29 recommended calcium supplementation with doses varying from 0.5 to 2 g of elemental calcium per day. Most of these guidelines were from upper middle- or high-income countries (19, 65.5%), whereas in countries where this recommendation is most needed, there is a lack of published calcium supplementation recommendations during pregnancy.

在一些国家,孕妇的钙摄入量达不到最佳水平,由于产妇高血压疾病,死亡率很高。在怀孕期间补充钙可以降低这些疾病的风险,并建议饮食钙摄入量低的孕妇预防先兆子痫。我们的目的是评估世界卫生组织(世卫组织)建议在怀孕期间补充钙以预防先兆子痫的全球采用情况。在2024年1月至7月期间,检索了每个世卫组织成员国卫生部网站谷歌和世卫组织数据库,以确定国家产前保健指南。我们发现,在本综述纳入的194个国家中,有92个国家(47.4%)在2007年至2024年间发布了与妊娠相关的指南,其中58个(63%)包括钙摄入建议,29个建议钙补充剂量从每天0.5至2g不等。这些指南大多来自中高收入或高收入国家(19.65.5%),而在最需要这一建议的国家,缺乏公布的怀孕期间补钙建议。
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引用次数: 0
A Real-Time Defect Detector With Content-Guided Feature Extraction and Detail Enhancement 基于内容导向特征提取和细节增强的实时缺陷检测器。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-03 DOI: 10.1111/nyas.70123
Yuefei Huang, Tingting Fang, Ming Ye

Surface defect detection in industrial materials faces two main challenges: complex backgrounds and missed small defects. To address these problems, this paper presents CGRNet, an efficient real-time detector. CGRNet introduces a content-guided feature extraction network that uses global context to guide adaptive high-frequency filtering. This suppresses low-frequency noise and enhances edge and local features. The detail enhancement module with a double residual attention mechanism integrates channel-specific spatial attention maps for multi-scale feature interaction. This integration improves the detection of small defects. The SIoU loss function and Lion optimizer speed up convergence and improve localization accuracy. Experimental results show that CGRNet achieves a 93.6% mAP on the PVEL_AD dataset, surpassing existing methods in accuracy. On the NEU-DET dataset, the model runs at 81.9 frames per second, satisfying real-time application requirements.

工业材料表面缺陷检测面临两个主要挑战:复杂的背景和细小缺陷的遗漏。为了解决这些问题,本文提出了一种高效的实时检测器CGRNet。CGRNet引入了一种内容导向的特征提取网络,该网络利用全局上下文指导自适应高频滤波。这抑制了低频噪声,增强了边缘和局部特征。细节增强模块采用双剩余注意机制,集成了通道特定空间注意图,实现多尺度特征交互。这种集成改进了对小缺陷的检测。SIoU损失函数和Lion优化器加快了收敛速度,提高了定位精度。实验结果表明,CGRNet在PVEL_AD数据集上的mAP准确率达到93.6%,优于现有方法。在nue - det数据集上,模型以81.9帧/秒的速度运行,满足实时应用需求。
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引用次数: 0
Music Reward Sensitivity Associated With Frontostriatal Function and Structure in Congenital Amusia 先天性失音症中与额纹状体功能和结构相关的音乐奖励敏感性。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-03 DOI: 10.1111/nyas.70125
Zhishuai Jin, Sizhu Huyang, Lichen Jiang, Qiaoping Lian, Daxing Wu

Congenital amusia is a neurodevelopmental disorder affecting musical ability. Previous studies have demonstrated that music reward sensitivity has both functional and structural bases. However, the nature of music reward sensitivity and its neural underpinnings in amusia remains unclear. This study combined the Barcelona Music Reward Questionnaire and magnetic resonance imaging to investigate resting-state functional and structural correlates of music reward sensitivity in individuals with amusia. Behavioral results indicate individuals with amusia exhibit reduced sensitivity to music, including social rewards, mood regulation, emotional evocation, sensorimotor processing, and music seeking. Brain imaging revealed abnormalities in several classic cognitive and reward-related functional and structural brain areas. Specifically, individuals with amusia have abnormal resting-state functional activity in the right inferior frontal gyrus (IFG) along with altered functional and structural connectivity between the IFG and the striatum. Notably, reduced sensorimotor sensitivity to music in amusia is associated with increased resting-state functional activity in the IFG and enhanced structural connectivity between the IFG and nucleus accumbens (NAcc). Furthermore, the function of the IFG appears to influence the sensorimotor sensitivity via the IFG-NAcc structural connectivity in amusia. These findings suggest the cognitive system and its interactions with the reward system play crucial roles in developmental music disorder.

先天性失音症是一种影响音乐能力的神经发育障碍。先前的研究表明,音乐奖励敏感性既有功能基础,也有结构基础。然而,音乐奖励敏感性的本质及其在失音症中的神经基础仍不清楚。本研究结合巴塞罗那音乐奖励问卷和磁共振成像研究静息状态下失音症患者音乐奖励敏感性的功能和结构相关性。行为学结果表明,失音症患者对音乐的敏感性降低,包括社会奖励、情绪调节、情绪唤起、感觉运动加工和音乐寻找。脑成像显示在几个典型的认知和奖励相关的功能和结构脑区域异常。具体来说,患有失音症的个体在右侧额下回(IFG)有异常的静息状态功能活动,同时IFG和纹状体之间的功能和结构连接也发生了改变。值得注意的是,失音症患者对音乐的感觉运动敏感性降低与IFG静息状态功能活动增加以及IFG与伏隔核(NAcc)之间结构连通性增强有关。此外,IFG的功能似乎通过IFG- nacc结构连接影响失音症的感觉运动敏感性。这些发现表明,认知系统及其与奖励系统的相互作用在发展性音乐障碍中起着至关重要的作用。
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引用次数: 0
Skin Lesion Classification Using Focal Modulation Networks 使用焦点调制网络进行皮肤病变分类。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-03 DOI: 10.1111/nyas.70139
Hasan Zan

The automatic classification of dermoscopic images is essential for the early diagnosis and treatment of skin cancer. However, this task remains challenging due to high visual similarity among lesion types, variations in lesion appearance across progression stages, and the presence of artifacts in the images. While deep learning-based approaches have outperformed traditional machine learning methods, many existing models are computationally intensive and offer limited interpretability. These limitations hinder their integration into clinical workflows where efficiency and transparency are critical. In this study, I propose a framework based on focal modulation networks (FMNs) for skin lesion classification. FMNs are designed to efficiently capture both local and global features, addressing the limitations of transformer-based models in processing high-resolution medical images. I evaluate four FMN variants, namely, Tiny, Small, Base, and Large, on three public datasets: ISIC 2017, ISIC 2018, and ISIC 2019. The highest classification accuracy was obtained on ISIC 2019 with 97.8%, followed by 96.4% on ISIC 2018, and 88.1% on ISIC 2017. These results match or exceed those reported in several previous studies. Additionally, FMNs offer model interpretability through modulator visualization. Overall, the proposed method provides an accurate, efficient, and transparent solution for automated skin lesion classification.

皮肤镜图像的自动分类对于皮肤癌的早期诊断和治疗至关重要。然而,由于病变类型之间的高度视觉相似性,病变在进展阶段的外观变化以及图像中存在伪影,这项任务仍然具有挑战性。虽然基于深度学习的方法优于传统的机器学习方法,但许多现有模型都是计算密集型的,并且提供有限的可解释性。这些限制阻碍了它们整合到效率和透明度至关重要的临床工作流程中。在这项研究中,我提出了一个基于焦点调制网络(FMNs)的皮肤病变分类框架。FMNs旨在有效捕获局部和全局特征,解决基于变压器的模型在处理高分辨率医学图像中的局限性。我在三个公共数据集(ISIC 2017、ISIC 2018和ISIC 2019)上评估了四种FMN变体,即Tiny、Small、Base和Large。ISIC 2019的分类准确率最高,为97.8%,其次是ISIC 2018的96.4%,ISIC 2017的88.1%。这些结果与之前几项研究报告的结果相匹配或超过。此外,FMNs通过调制器可视化提供模型可解释性。总体而言,该方法为皮肤病变自动分类提供了准确、高效、透明的解决方案。
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引用次数: 0
What Sustains Wars: Will to Fight Versus Military Might 是什么维持了战争:战斗意志与军事力量
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-11-02 DOI: 10.1111/nyas.70113
Scott Atran

This essay explores the contributions of psychosocial factors in sustaining wars and other extreme group conflicts. It uses the Devoted Actor Framework (DAF) to better understand will to fight (WTF) as a quest for ontological significance. Devoted actors are viscerally and inseparably fused to one another and to their group by moral ideals often held to be sacred and indivisible, and thus highly resistant to negotiation and compromise. The quest for ontological significance involves affirming and securing group identities and associated moral ideals. The importance of WTF and reasons for its postwar neglect are highlighted in an analysis of initial versus later stages of the European theater in WWII. Next is an assessment of the limits of rational realism and the significance of religion and nationalism, followed by an examination of psychosocial factors involved in WTF via behavioral and brain studies in the Middle East, North Africa, Europe, and North America. The discussion section examines the scope and limits of DAF in terms of descriptive and explanatory power and in relation to other approaches to war and group conflict. A final coda addresses the Israel−Palestine conflict and the recent Gaza War to illustrate DAF's relevance for understanding and managing seemingly intractable conflicts.

本文探讨了社会心理因素在维持战争和其他极端群体冲突中的作用。它使用专用行动者框架(DAF)来更好地理解作为本体论意义探索的战斗意志(WTF)。忠诚的演员本能地和不可分割地与彼此和他们的群体融合在一起,这些道德理想通常被认为是神圣和不可分割的,因此他们高度抵制谈判和妥协。对本体论意义的追求包括肯定和确保群体身份和相关的道德理想。在对二战欧洲战场初期和后期的分析中,突出了WTF的重要性及其战后被忽视的原因。接下来是对理性现实主义的局限性以及宗教和民族主义的重要性的评估,然后通过在中东、北非、欧洲和北美进行的行为和大脑研究,对WTF中涉及的社会心理因素进行检查。讨论部分从描述和解释能力以及与其他战争和群体冲突方法的关系方面考察了DAF的范围和限制。最后的结尾处论述了以色列-巴勒斯坦冲突和最近的加沙战争,以说明DAF对理解和管理看似棘手的冲突的相关性。
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引用次数: 0
Retroflexion in the Stomach During Endoscopy: Importance of the Examination and Its Utility 胃内窥镜检查时的胃后屈:检查的重要性及其应用
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-10-31 DOI: 10.1111/nyas.70094
Kevin Huang, Hiroshi Mashimo

Endoscopic retroflexion in the stomach is an important diagnostic and therapeutic maneuver that is often underappreciated and underperformed by general endoscopists. Beyond providing a comprehensive visualization of the gastric cardia and fundus, the retroflexed endoscope is key to assessing the esophagogastric junction, identifying diaphragmatic hernias, and assessing wrap integrity after fundoplication. Such evaluation is critical given the ever-rising incidence of gastroesophageal reflux disorder, prevalence of diaphragmatic hernias, and demand for antireflux and antiobesity surgeries. Careful retroflexed inspection of the gastric cardia is also important in Helicobacter pylori infection, junctional cancers, and neoplasia associated with Barrett's esophagus. Retroflexion provides therapeutic options in ablation of Barrett's esophagus and dilation of subtle strictures. We review here the diagnostic and potential therapeutic importance of the retroflexed endoscope.

胃内翻是一种重要的诊断和治疗手法,但通常被普通内窥镜医师低估和执行不力。除了提供贲门和胃底的全面可视化外,后屈内窥镜是评估食管胃连接处、识别膈疝和评估胃底折叠后包裹完整性的关键。考虑到胃食管反流疾病的发病率不断上升、膈疝的患病率以及抗反流和抗肥胖手术的需求,这样的评估是至关重要的。在幽门螺杆菌感染、结膜癌和Barrett食管相关肿瘤时,仔细的逆行检查贲门也很重要。后屈为Barrett食管消融和细微狭窄扩张提供了治疗选择。我们在此回顾后屈内窥镜的诊断和潜在治疗的重要性。
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引用次数: 0
Comment on den Elzen et al. (2025): Clarifying India's Net-Zero Target and Uncertainty Analysis 对den Elzen等人(2025)的评论:澄清印度的净零目标和不确定性分析
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-10-30 DOI: 10.1111/nyas.70119
Ashish Sharma
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引用次数: 0
Enhancing Understanding and Interpretation of Ultrasound Images: A Tool for Fetal Congenital Heart Diseases 加强对超声图像的理解和解释:胎儿先天性心脏病的一种工具。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-10-30 DOI: 10.1111/nyas.70132
Chenchen Wei, Zhong Yang, Xinxin Yan, Muqing Lin, Li Xiao, Fang Wang, Min Wang, Qingxia Huang, Yue Wu, Ailin Zou, Zixuan Chen, Zhongshan Gou

This study aimed to evaluate the accuracy and efficiency of using a modeling tool named uSketch for generating patient-specific diagrams in cases of fetal congenital heart disease (CHD). Furthermore, it sought to explore the feasibility of employing uSketch to improve communication efficacy across diverse clinical settings. uSketch successfully produced matched diagrams for 941 cases (98.4%) by single-click, semi-automatic, or manual methods. The mean time required for diagram generation was significantly shorter with uSketch than that with hand-drawn sketches (0.88 ± 0.58 vs. 6.75 ± 2.95 min, p < 0.05). The expert panel unanimously concluded that uSketch exhibits professional-level capability in generating anatomical schematics for fetal CHD. Families with a CHD fetus receiving uSketch diagrams in addition to textual reports showed significantly higher questionnaire scores compared to those who received textual reports alone (p < 0.05). The questionnaire scores of medical students who utilized uSketch diagrams were significantly higher than those of their peers who employed traditional methods (p < 0.05). In conclusion, uSketch facilitates the generation of anatomical diagrams for fetal CHD. It achieves a remarkable coverage rate of 98.4% by automatic, semi-automatic, or manual methods. The deployment of uSketch can substantially enhance communication effectiveness across various clinical and educational contexts.

本研究旨在评估使用ussketch建模工具在胎儿先天性心脏病(CHD)病例中生成患者特异性图的准确性和效率。此外,它试图探索使用uSketch在不同临床环境中提高沟通效率的可行性。uSketch通过点击、半自动或手动的方法成功生成了941例(98.4%)的匹配图。ussketch生成图表所需的平均时间显著短于手绘草图(0.88±0.58 min vs. 6.75±2.95 min, p < 0.05)。专家小组一致认为,ussketch在生成胎儿CHD解剖示意图方面表现出专业水平的能力。接受uSketch图表和文字报告的CHD胎儿家庭的问卷得分明显高于只接受文字报告的家庭(p < 0.05)。使用uSketch图的医学生问卷得分显著高于使用传统方法的医学生(p < 0.05)。总之,ussketch有助于生成胎儿冠心病的解剖图。通过自动、半自动或手动方法,它达到了98.4%的显著覆盖率。部署uSketch可以大大提高各种临床和教育背景下的沟通效率。
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引用次数: 0
Mycoplasma agassizii Multilocus Sequence Typing Using Nanopore Sequencing: Insights Into Genetic Diversity and Isolate Characterization 使用纳米孔测序的阿加西支原体多位点序列分型:对遗传多样性和分离物特性的见解。
IF 4.8 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2025-10-30 DOI: 10.1111/nyas.70128
Carla Cacciotto, Rosanna Zobba, Manuel Louro, Margarida Alves, Andreia Valença, Rui Patrício, Emanuela Bazzoni, Marco Pittau, Roberta Lecis, Alberto Alberti

Mycoplasma agassizii (Mycoplasmopsis agassizii) is a major pathogen responsible for upper respiratory tract disease (URTD) in tortoises, contributing to worldwide population declines. Despite its significance, tools for strain-level identification and epidemiological tracking remain limited. This study proposes a Multilocus Sequence Typing (MLST) scheme based on eight housekeeping genes (uvrB, tpiA, gyrB, efTu, rpoB, uvrA, gmK, and atpG), combined with Nanopore sequencing, to characterize M. agassizii isolates from tortoises in Italy and Portugal. Among 127 samples, 73 (57.5%) tested positive for M. agassizii. Analysis of 15 isolates revealed 14 distinct sequence types (STs). High genetic diversity was observed, even among samples from the same rescue centers. No correlation was found between STs and geographic origin or tortoise species. Four loci (uvrB, gyrB, rpoB, and gmK) were sufficient to discriminate all STs at a haplotype diversity cut-off ≥ 0.83. The standardized index of association (Ia = 0.2246) suggests a partially clonal population with evidence of recombination. This MLST scheme offers a promising tool for tracking M. agassizii strain diversity and understanding its epidemiology. Broader application across symptomatic and asymptomatic hosts is needed to evaluate associations between specific strains and disease outcomes, which will support conservation and URTD control efforts in tortoises.

阿加西支原体(Mycoplasmopsis agassizii)是导致陆龟上呼吸道疾病(URTD)的主要病原体,导致世界范围内陆龟数量下降。尽管具有重要意义,但菌株水平鉴定和流行病学追踪的工具仍然有限。本研究提出了一种基于8个持家基因(uvrB、tpiA、gyrB、efTu、rpoB、uvrA、gmK和atpG)的多位点序列分型(MLST)方案,并结合纳米孔测序对意大利和葡萄牙陆龟分离的阿加西米氏菌进行了表征。127份样品中,有73份(57.5%)呈阳性。对15株分离株的分析显示出14种不同的序列类型(STs)。观察到高度的遗传多样性,甚至在来自同一救援中心的样本中也是如此。STs与地理来源或陆龟种类之间没有相关性。4个位点(uvrB、gyrB、rpoB和gmK)足以区分所有st,单倍型多样性截止值≥0.83。标准化关联指数(Ia = 0.2246)表明群体为部分无性系,存在重组证据。该MLST方案为跟踪小麦黑穗病菌株多样性和了解其流行病学提供了一个有前途的工具。需要在有症状和无症状宿主之间进行更广泛的应用,以评估特定菌株与疾病结果之间的关联,这将支持龟的保护和URTD控制工作。
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引用次数: 0
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