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Role of S100β in Patients with Unstable Angina Pectoris: Insights from Quantitative Flow Ratio S100β 在不稳定型心绞痛患者中的作用:定量血流比率的启示。
IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-07-01 DOI: 10.1016/j.arcmed.2024.103034
Zhihao Liu , Jun Wang , Fuding Guo , Tianyou Xu , Fu Yu , Qiang Deng , Wuping Tan , Shoupeng Duan , Lingpeng Song , Yijun Wang , Ji Sun , Liping Zhou , Yueyi Wang , Xiaoya Zhou , Hao Xia , Hong Jiang

Background and objective

Disturbed autonomic nervous system (ANS) may promote inflammatory, immune, and oxidative stress responses, which may increase the risk of acute coronary events. S100β has been proposed as a biomarker of neuronal injury that would provide an insightful understanding of the crosstalk between the ANS, immune-inflammatory cells, and plaques that drive atherosclerosis. This study investigates the correlation between S100β, and functional coronary stenosis as determined by quantitative flow ratio (QFR).

Methods

Patients with unstable angina pectoris (UAP) scheduled for coronary angiography and QFR were retrospectively enrolled. Serum S100β levels were determined by enzyme-linked immunosorbent assay. The Gensini score was used to estimate the extent of atherosclerotic lesions and the cumulative sum of three-vessel QFR (3V-QFR) was calculated to estimate the total atherosclerotic burden.

Results

Two hundred thirty-three patients were included in this study. Receiver operator characteristic (ROC) curve indicated that S100β>33.28 pg/mL predicted functional ischemia in patients with UAP. Multivariate logistic analyses showed that a higher level of S100β was independently correlated with a functional ischemia-driven target vessel (QFR ≤0.8). This was also closely correlated with the severity of coronary lesions, as measured by the Gensini score (OR = 5.058, 95% CI: 2.912–8.793, p <0.001). According to 3V-QFR, S100β is inversely associated with total atherosclerosis burden (B = –0.002, p <0.001).

Conclusions

S100β was elevated in the functional ischemia stages of UAP. It was independently associated with coronary lesion severity as assessed by Gensini score and total atherosclerosis burden as estimated by 3V-QFR in patients with UAP.

背景和目的:自律神经系统(ANS)紊乱可能会促进炎症、免疫和氧化应激反应,从而增加急性冠状动脉事件的风险。S100β 被认为是神经元损伤的生物标志物,它将有助于深入了解自律神经系统、免疫炎症细胞和动脉粥样硬化斑块之间的相互影响。本研究探讨了 S100β 与定量血流比(QFR)测定的功能性冠状动脉狭窄之间的相关性:方法:研究人员回顾性纳入了计划接受冠状动脉造影术和定量血流比测定的不稳定型心绞痛(UAP)患者。血清 S100β 水平通过酶联免疫吸附试验测定。Gensini 评分用于估算动脉粥样硬化病变的范围,三血管 QFR 的累积总和(3V-QFR)用于估算动脉粥样硬化的总负担:本研究共纳入 233 名患者。接收器操作特征(ROC)曲线显示,S100β>33.28 pg/mL可预测UAP患者的功能性缺血。多变量逻辑分析表明,较高水平的 S100β 与功能性缺血驱动的靶血管(QFR ≤0.8)独立相关。这也与以 Gensini 评分衡量的冠状动脉病变严重程度密切相关(OR = 5.058,95% CI:2.912-8.793,p 结论:S100β 的升高与冠状动脉病变的严重程度密切相关:S100β在UAP功能性缺血阶段升高。在 UAP 患者中,S100β 与用 Gensini 评分评估的冠状动脉病变严重程度和用 3V-QFR 估算的总动脉粥样硬化负荷有独立关联。
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引用次数: 0
Response to: Comment on “Effect of Fibrate Treatment on Circulating Adipokine Levels: A Systematic Review and Meta-analysis of Randomized Clinical Trials” 回应:关于 "菲贝特治疗对循环脂肪因子水平的影响:随机临床试验的系统回顾和元分析 "的评论
IF 4.7 3区 医学 Q1 Medicine Pub Date : 2024-06-21 DOI: 10.1016/j.arcmed.2024.103028
LUIS E. SIMENTAL-MENDÍA , MARIO SIMENTAL-MENDÍA , AMIRHOSSEIN SAHEBKAR , TANNAZ JAMIALAHMADI
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引用次数: 0
In Vitro Human Endometrial Cells and In Vivo Rat Model Studies Suggest That Ulipristal Acetate Impacts Endometrial Compatibility for Embryo Implantation 体外人类子宫内膜细胞和体内大鼠模型研究表明,醋酸乌利司他会影响子宫内膜与胚胎着床的兼容性。
IF 4.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2024-06-19 DOI: 10.1016/j.arcmed.2024.103026

Background

Ulipristal acetate (UPA) and levonorgestrel are used as emergency hormonal contraceptives. Although both are highly effective in preventing pregnancy, UPA shows efficacy even when taken up to 120 h after unprotected sexual intercourse.

Aims

To investigate whether the mechanism of UPA's contraceptive action involves post-fertilization effects.

Methods

In vitro and in vivo studies using cultured human endometrial cells and a pre-clinical rat model.

Results

Endometrial cells treated with UPA showed changes in the expression of receptivity gene markers and a significant decrease in trophoblast spheroids attached to the cultured cells. In addition, administration of UPA to female unmated rats decreased the expression of implantation-related genes in the endometrium and inhibited the number of implantation sites in the mated group compared to the non-treated group.

Conclusions

These results support that UPA as an emergency contraceptive might have post-fertilization effects that may affect embryo implantation.

背景:醋酸乌利司他(UPA)和左炔诺孕酮被用作紧急激素避孕药。目的:研究 UPA 的避孕作用机制是否涉及受精后效应:方法:使用培养的人类子宫内膜细胞和临床前大鼠模型进行体外和体内研究:结果:经 UPA 处理的子宫内膜细胞的受孕基因标志物的表达发生了变化,附着在培养细胞上的滋养细胞球明显减少。此外,与未处理组相比,给未交配的雌性大鼠服用 UPA 可降低子宫内膜植入相关基因的表达,并抑制交配组植入点的数量:这些结果证明,作为一种紧急避孕药,UPA可能会产生受精后效应,从而影响胚胎着床。
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引用次数: 0
Comment on “Effect of Fibrate Treatment on Circulating Adipokine Levels: A Systematic Review and Meta-analysis of Randomized Clinical Trials” 关于 "菲贝特治疗对循环脂肪因子水平的影响:随机临床试验的系统回顾和元分析"
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-18 DOI: 10.1016/j.arcmed.2024.103027
LANG LI , XUE ZHAO , XUEYANG TANG
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引用次数: 0
Resistance Exercise Reduces Sarcopenia by Repairing Leaky Gut in Patients With Alzheimer's Disease 阻力运动通过修复阿尔茨海默病患者的肠道渗漏,减少肌肉疏松症的发生
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-16 DOI: 10.1016/j.arcmed.2024.103025
Rizwan Qaisar , M. Shahid Iqbal , Asima Karim , Firdos Ahmad

Purpose

Sarcopenia or age-associated muscle loss is common in patients with Alzheimer's disease (AD). We have previously demonstrated the contribution of a leaky gut to sarcopenia in AD. Here, we asked whether resistant exercise (RE) reduces the sarcopenia phenotype by repairing intestinal leakage in patients with AD.

Method

A prospective, single-center study of older adults, including healthy controls and patients with AD (n = 44–51/group), was conducted to measure plasma zonulin and claudin-3 (markers of intestinal leakage), handgrip strength (HGS), and short physical performance battery (SPPB) as a measure of functional capacity. Measurements in patients with AD were performed at baseline and after 12 weeks of RE.

Results

At baseline, patients with AD had higher plasma zonulin and claudin-3 and lower HGS, gait speed, and SPPB scores than controls. RE reduced plasma zonulin and claudin-3 levels and improved HGS, SPPB scores, and gait speed. Regression analysis revealed robust relationships between changes in plasma zonulin and claudin-3 with HGS. Plasma zonulin was also positively associated with SPPB scores. In addition, RE downregulated plasma markers of inflammation and oxidative stress. However, the prevalence of sarcopenia based on low HGS and muscle atrophy or low SPPB was not affected by RE.

Conclusion

Taken together, disruption of the intestinal mucosal barrier may contribute to functional decline and sarcopenia in AD, which is incompletely recovered by RE. Circulating levels of zonulin and claudin-3 may be valuable in predicting sarcopenia and functional capacity in older adults with AD.

目的:在阿尔茨海默病(AD)患者中,肌肉疏松症或与年龄相关的肌肉流失很常见。我们以前曾证实,肠道渗漏是导致阿兹海默症患者肌肉疏松症的原因之一。在此,我们想知道抗阻力运动(RE)是否能通过修复 AD 患者的肠道渗漏来减少肌肉疏松症表型:方法:我们对包括健康对照组和 AD 患者(44-51 人/组)在内的老年人进行了一项前瞻性单中心研究,以测量血浆 zonulin 和 claudin-3(肠道渗漏的标志物)、手握强度(HGS)以及作为功能能力测量指标的短期体能测试(SPPB)。对注意力缺失症患者的测量在基线和 RE 12 周后进行:与对照组相比,基线时 AD 患者的血浆 zonulin 和 claudin-3 较高,HGS、步速和 SPPB 分数较低。RE降低了血浆zonulin和claudin-3水平,改善了HGS、SPPB评分和步速。回归分析显示,血浆zonulin和claudin-3的变化与HGS之间存在密切关系。血浆zonulin还与SPPB评分呈正相关。此外,RE 下调了血浆中的炎症和氧化应激标记物。然而,RE 对基于低 HGS 和肌肉萎缩或低 SPPB 的肌少症发病率没有影响:综上所述,肠粘膜屏障的破坏可能会导致AD患者的功能衰退和肌少症,而RE又不能完全恢复这种功能衰退和肌少症。循环中的zonulin和claudin-3水平可能对预测患有AD的老年人的肌少症和功能能力有价值。
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引用次数: 0
Strengthening Essential Health Services Recovery Policy after the COVID-19 Pandemic. Evidence from the Mexican Institute of Social Security COVID-19 大流行后加强基本医疗服务恢复政策。来自墨西哥社会保障局的证据
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-14 DOI: 10.1016/j.arcmed.2024.103011
Svetlana V. Doubova , Saúl Eduardo Contreras-Sánchez , Ivan de Jesús Ascencio-Montiel , Margot González-León , Ernesto Krug-Llamas , Gabriela Borrayo-Sánchez , Laura C. Bonifaz , Ricardo Aviles-Hernández , Célida Duque-Molina , Zoe Robledo-Aburto

Aim

To evaluate the progress of the Mexican Institute of Social Security Recovery Policy (IMSS-RP) in addressing the decline in essential health services caused by the COVID-19 pandemic.

Methods

We analyzed eleven indicators of essential health services from 35 IMSS state delegations. The assessment included ambulatory and hospital care indicators such as breast and cervical cancer screening, family medicine, dental and specialty visits, diabetes and hypertension visits and health outcomes, deliveries, and elective surgeries. We analyzed the period before (January 2018–March 2021) and during (April 2021–June 2023) the implementation of the IMSS-RP. Statistical analysis to determine the association of the policy with service indicators and the change in their trends included an interrupted time series analysis and Poisson Generalized Estimating Equation models.

Results

The volume of services showed substantial declines during the first year of the COVID-19 pandemic, reaching between 11 and 81% of pre-pandemic levels. All services increased significantly during the first 27 months of the IMSS-RP implementation; specialty visits, cervical and breast cancer screening, and diabetes control exceeded pre-pandemic levels (103%,112%,103%, and 138%, respectively). However, only deliveries and the percentage of patients with controlled diabetes and hypertension showed a stable increase following the IMSS-RP implementation, whereas the remaining services showed an initial increase but began to decrease over time.

Conclusions

After 27 months of implementation, IMSS-RP achieved progress in increasing the volume of essential health services and improving chronic disease control. However, declining trends in several services signal the need to focalize the policy.

目的评估墨西哥社会保障恢复政策研究所(IMSS-RP)在应对 COVID-19 大流行导致的基本医疗服务下降方面所取得的进展。方法我们分析了来自 35 个墨西哥社会保障恢复政策研究所州代表团的 11 项基本医疗服务指标。评估包括门诊和医院护理指标,如乳腺癌和宫颈癌筛查、家庭医疗、牙科和专科就诊、糖尿病和高血压就诊及健康结果、分娩和择期手术。我们对 IMSS-RP 实施前(2018 年 1 月至 2021 年 3 月)和实施期间(2021 年 4 月至 2023 年 6 月)进行了分析。统计分析包括中断时间序列分析和泊松广义估计方程模型,以确定该政策与服务指标及其趋势变化之间的关联。在实施 IMSS-RP 的前 27 个月中,所有服务都大幅增加;专科门诊、宫颈癌和乳腺癌筛查以及糖尿病控制都超过了大流行前的水平(分别为 103%、112%、103% 和 138%)。结论经过 27 个月的实施,IMSS-RP 在增加基本医疗服务数量和改善慢性疾病控制方面取得了进展。然而,几项服务的下降趋势表明,有必要对政策进行重点调整。
{"title":"Strengthening Essential Health Services Recovery Policy after the COVID-19 Pandemic. Evidence from the Mexican Institute of Social Security","authors":"Svetlana V. Doubova ,&nbsp;Saúl Eduardo Contreras-Sánchez ,&nbsp;Ivan de Jesús Ascencio-Montiel ,&nbsp;Margot González-León ,&nbsp;Ernesto Krug-Llamas ,&nbsp;Gabriela Borrayo-Sánchez ,&nbsp;Laura C. Bonifaz ,&nbsp;Ricardo Aviles-Hernández ,&nbsp;Célida Duque-Molina ,&nbsp;Zoe Robledo-Aburto","doi":"10.1016/j.arcmed.2024.103011","DOIUrl":"https://doi.org/10.1016/j.arcmed.2024.103011","url":null,"abstract":"<div><h3>Aim</h3><p>To evaluate the progress of the Mexican Institute of Social Security Recovery Policy (IMSS-RP) in addressing the decline in essential health services caused by the COVID-19 pandemic.</p></div><div><h3>Methods</h3><p>We analyzed eleven indicators of essential health services from 35 IMSS state delegations. The assessment included ambulatory and hospital care indicators such as breast and cervical cancer screening, family medicine, dental and specialty visits, diabetes and hypertension visits and health outcomes, deliveries, and elective surgeries. We analyzed the period before (January 2018–March 2021) and during (April 2021–June 2023) the implementation of the IMSS-RP. Statistical analysis to determine the association of the policy with service indicators and the change in their trends included an interrupted time series analysis and Poisson Generalized Estimating Equation models.</p></div><div><h3>Results</h3><p>The volume of services showed substantial declines during the first year of the COVID-19 pandemic, reaching between 11 and 81% of pre-pandemic levels. All services increased significantly during the first 27 months of the IMSS-RP implementation; specialty visits, cervical and breast cancer screening, and diabetes control exceeded pre-pandemic levels (103%,112%,103%, and 138%, respectively). However, only deliveries and the percentage of patients with controlled diabetes and hypertension showed a stable increase following the IMSS-RP implementation, whereas the remaining services showed an initial increase but began to decrease over time.</p></div><div><h3>Conclusions</h3><p>After 27 months of implementation, IMSS-RP achieved progress in increasing the volume of essential health services and improving chronic disease control. However, declining trends in several services signal the need to focalize the policy.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141324303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Impairment Induced by Gestational Diabetes: Implications of Oxidative Stress as an Inducing Mechanism 妊娠糖尿病诱发的认知障碍:氧化应激作为诱导机制的意义
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-12 DOI: 10.1016/j.arcmed.2024.103016
Isabel Martin del Campo-Rota , Oscar Mario Delgado-Casillas , Antonio Ibarra

Background

Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.

Aims

We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.

Methods

We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.

Results

From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.

Conclusion

Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.

背景认知障碍被定义为改变推理、记忆、注意力和联想等多种大脑功能的神经系统疾病。研究发现,认知障碍与氧化应激等多种因素密切相关。氧化应激可由多种病理情况诱发,其特点是自由基水平升高和抗氧化剂水平降低。由于荷尔蒙变化和维持妊娠所需的氧气增加,妇女在怀孕期间会出现氧化应激的生理状态。然而,当氧化应激超过抗氧化能力时,就会导致细胞损伤,从而引发糖尿病。最近的研究表明,妊娠期糖尿病与认知功能障碍之间可能存在关联,但其潜在机制仍不清楚。我们的关键词是 "神经炎症"、"认知障碍"、"妊娠糖尿病"、"氧化应激"、"抗氧化剂 "和 "自由基"。结果从最初确定的 400 条记录中,共分析了 78 项研究并将其纳入我们的研究。了解这种相关性对于制定有针对性的医疗干预措施至关重要,并最终促进研究和预防工作,使母子二人在短期和长期内受益。
{"title":"Cognitive Impairment Induced by Gestational Diabetes: Implications of Oxidative Stress as an Inducing Mechanism","authors":"Isabel Martin del Campo-Rota ,&nbsp;Oscar Mario Delgado-Casillas ,&nbsp;Antonio Ibarra","doi":"10.1016/j.arcmed.2024.103016","DOIUrl":"https://doi.org/10.1016/j.arcmed.2024.103016","url":null,"abstract":"<div><h3>Background</h3><p>Cognitive impairment is defined as a neurological condition that alters multiple cerebral functions such as reasoning, memory, concentration, and association, among others. It has found to be widely correlated with several factors such as oxidative stress. The latter could be induced by numerous pathological conditions characterized by increased levels of free radicals and decreased levels of antioxidants. Pregnancy is a period when women undergo a physiological state of oxidative stress due to hormonal changes and increased oxygen requirements to maintain pregnancy. However, when oxidative stress exceeds antioxidant capacity, this leads to cellular damage that promotes a diabetogenic state. Recent studies suggest a possible association between gestational diabetes and cognitive impairment, but the underlying mechanisms remain unclear.</p></div><div><h3>Aims</h3><p>We aim to explore the pathophysiological relationship between cognitive impairment and oxidative stress, focusing on the possible involvement of oxidative stress as the inducing mechanism.</p></div><div><h3>Methods</h3><p>We performed a comprehensive literature review through PubMed and Google Scholar. Our keywords were “neuroinflammation”, “cognitive impairment”, “gestational diabetes”, “oxidative stress”, “antioxidants”, and “free radicals”.</p></div><div><h3>Results</h3><p>From the initial 400 records identified, a total of 78 studies were analyzed and included in our study.</p></div><div><h3>Conclusion</h3><p>Oxidative stress plays a fundamental role in the development of cognitive impairment. Understanding this correlation is essential to the development of targeted medical interventions and, ultimately, promote research and prevention that will benefit the mother-child binomial in the short and long term.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141313830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underlying Mechanisms of the Protective Effects of Lifestyle Factors in the Prevention of Age-Related Diseases 生活方式因素对预防老年相关疾病的保护作用的基本机制
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-10 DOI: 10.1016/j.arcmed.2024.103014
Nicolás Alcaráz , Pamela Salcedo-Tello , Rodrigo González-Barrios , Karla Torres-Arciga , Kioko Guzmán-Ramos

The rise in life expectancy has significantly increased the occurrence of age-related chronic diseases, leading to escalating expenses for both society and individuals. Among the main factors influencing health and lifespan, lifestyle takes a forefront position. Specifically, nutrition, mental activity, and physical exercise influence the molecular and functional mechanisms that contribute to the prevention of major age-related diseases. Gaining deeper insights into the mechanisms that drive the positive effects of healthy lifestyles is valuable for creating interventions to prevent or postpone the development of chronic degenerative diseases. This review summarizes the main mechanisms that underlie the positive effect of lifestyle factors in counteracting the major age-related diseases involving brain health, musculoskeletal function, cancer, frailty, and cardiovascular diseases, among others. This knowledge will help to identify high-risk populations for targeted intervention trials and discover new biomarkers associated with healthy aging.

预期寿命的延长大大增加了老年慢性病的发病率,导致社会和个人的支出不断攀升。在影响健康和寿命的主要因素中,生活方式占首要地位。具体来说,营养、精神活动和体育锻炼会影响分子和功能机制,从而有助于预防主要的老年相关疾病。深入了解健康生活方式产生积极影响的机制,对于制定预防或推迟慢性退行性疾病发展的干预措施非常有价值。本综述总结了生活方式因素在抵御主要老年相关疾病(包括脑健康、肌肉骨骼功能、癌症、虚弱和心血管疾病等)方面积极作用的主要机制。这些知识将有助于确定高风险人群,进行有针对性的干预试验,并发现与健康老龄化相关的新生物标志物。
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引用次数: 0
Quantitative Magnetic Resonance Biomarkers Identify Significant Recovery from Spinal Cord Injury after Bioactive Implants 定量磁共振生物标志物确定生物活性植入物对脊髓损伤的显著恢复作用
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-08 DOI: 10.1016/j.arcmed.2024.103012
DIANA OSORIO-LONDOÑO , AXAYÁCATL MORALES-GUADARRAMA , ROBERTO OLAYO-GONZÁLEZ , ERNESTO ROLDAN-VALADEZ
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引用次数: 0
Autoantigen Exposure in Murine Fetuses Elicited Nonpathogenic Autoimmunity 小鼠胎儿暴露于自身抗原会诱发非致病性自身免疫
IF 7.7 3区 医学 Q1 Medicine Pub Date : 2024-06-08 DOI: 10.1016/j.arcmed.2024.103013
Jeng-Chang Chen , Liang-Shiou Ou , Ming-Ling Kuo , Li-Yun Tseng , Hsueh-Ling Chang

Background and aim

Autoimmunity refers to the presence of autoantibodies and autoreactive lymphocytes against the structural molecules of an individual's cells or tissues, known as self-antigens or autoantigens. It might exist in the absence of autoimmune disease. However, how autoimmunity develops remains a mystery, despite the discovery of autoantibodies in human cord blood.

Methods

Murine fetuses on day 14 of gestation were subjected to intraperitoneal injection of murine thyroid peroxidase (TPO) peptides or collagen type II (CII) at graded doses via transuterine approach. Postnatally, the recipients were examined for autoantibodies by ELISA and autoreactive lymphocytes by in vitro incorporation of tritium and for the development of autoimmune thyroiditis or arthritis.

Results

At one month of age, the recipients did not secrete significant levels of anti-TPO or CII IgG2a in sera until a dose of 0.5 µg TPO or 5.0 µg CII was injected in utero. Serum anti-TPO or CII IgG2a persisted for at least two to four months postnatally. In recipients with elevated autoantibodies, their lymphocytes also showed proliferative responses specifically to TPO or CII. However, the development of autoantibodies and autoreactive lymphocytes was not associated with inflammatory cell infiltration of thyroid glands or paw joints even though anti-TPO or CII IgG2a was enhanced by postnatal TPO or CII challenge.

Conclusion

Fetal exposure to free autoantigens could be immunogenic, shedding new light on the in utero origin of autoantibodies and autoreactive lymphocytes. The development of autoimmunity requires a threshold intensity of autoantigen exposure in the fetus.

背景和目的自身免疫是指针对个体细胞或组织结构分子(称为自身抗原或自身抗原)的自身抗体和自身反应性淋巴细胞的存在。在没有自身免疫疾病的情况下,自身免疫也可能存在。方法通过经子宫途径向妊娠第 14 天的小鼠胎儿腹腔内注射分级剂量的小鼠甲状腺过氧化物酶(TPO)肽或 II 型胶原蛋白(CII)。结果一个月大时,受体血清中抗TPO或CII IgG2a的水平并不明显,直到宫内注射了0.5微克TPO或5.0微克CII。血清中的抗血小板生成素或 CII IgG2a 在出生后至少持续 2 到 4 个月。在自身抗体升高的受体中,他们的淋巴细胞也显示出对 TPO 或 CII 的特异性增殖反应。结论胎儿暴露于游离自身抗原可能具有免疫原性,这为自身抗体和自身反应性淋巴细胞在子宫内的来源提供了新的线索。自身免疫的发展需要胎儿暴露于自身抗原的阈值强度。
{"title":"Autoantigen Exposure in Murine Fetuses Elicited Nonpathogenic Autoimmunity","authors":"Jeng-Chang Chen ,&nbsp;Liang-Shiou Ou ,&nbsp;Ming-Ling Kuo ,&nbsp;Li-Yun Tseng ,&nbsp;Hsueh-Ling Chang","doi":"10.1016/j.arcmed.2024.103013","DOIUrl":"https://doi.org/10.1016/j.arcmed.2024.103013","url":null,"abstract":"<div><h3>Background and aim</h3><p>Autoimmunity refers to the presence of autoantibodies and autoreactive lymphocytes against the structural molecules of an individual's cells or tissues, known as self-antigens or autoantigens. It might exist in the absence of autoimmune disease. However, how autoimmunity develops remains a mystery, despite the discovery of autoantibodies in human cord blood.</p></div><div><h3>Methods</h3><p>Murine fetuses on day 14 of gestation were subjected to intraperitoneal injection of murine thyroid peroxidase (TPO) peptides or collagen type II (CII) at graded doses via transuterine approach. Postnatally, the recipients were examined for autoantibodies by ELISA and autoreactive lymphocytes by <em>in vitro</em> incorporation of tritium and for the development of autoimmune thyroiditis or arthritis.</p></div><div><h3>Results</h3><p>At one month of age, the recipients did not secrete significant levels of anti-TPO or CII IgG<sub>2a</sub> in sera until a dose of 0.5 µg TPO or 5.0 µg CII was injected <em>in utero</em>. Serum anti-TPO or CII IgG<sub>2a</sub> persisted for at least two to four months postnatally. In recipients with elevated autoantibodies, their lymphocytes also showed proliferative responses specifically to TPO or CII. However, the development of autoantibodies and autoreactive lymphocytes was not associated with inflammatory cell infiltration of thyroid glands or paw joints even though anti-TPO or CII IgG<sub>2a</sub> was enhanced by postnatal TPO or CII challenge.</p></div><div><h3>Conclusion</h3><p>Fetal exposure to free autoantigens could be immunogenic, shedding new light on the <em>in utero</em> origin of autoantibodies and autoreactive lymphocytes. The development of autoimmunity requires a threshold intensity of autoantigen exposure in the fetus.</p></div>","PeriodicalId":8318,"journal":{"name":"Archives of Medical Research","volume":null,"pages":null},"PeriodicalIF":7.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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