Archives of Medical Research最新文献

英文中文

Neuromodulation and Exercise Therapy: A Synergistic Approach to Improve Physical Mobility 神经调节和运动疗法：一种提高身体活动能力的协同方法

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2026-01-01 Epub Date: 2025-08-20 DOI: 10.1016/j.arcmed.2025.103282

JIA DONG JAMES WANG , LING-LING CHAN , YEW LONG LO , ENG KING TAN

引用次数: 0

Use and Conditions of a Breastfeeding Room in a Tertiary Health Institution: An Exploratory Study 三级卫生机构母乳喂养室的使用和条件：一项探索性研究

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2026-01-01 Epub Date: 2025-08-28 DOI: 10.1016/j.arcmed.2025.103284

Loraine Ledón-Llanes , Martha Kaufer-Horwitz , Consuelo Lomas-Soria , Berenice Palacios-González , Elena Zambrano

Background

Creating environments that facilitate breastfeeding (BF) practice in the workplace is an effective way to promote BF. However, few studies have addressed this sensitive and relevant topic in Mexican healthcare institutions.

Objective

Describe the conditions and use of the breastfeeding room (BFR) at a tertiary health institution and identify the perceptions of reproductive-age female workers, and the department heads and human resources staff (DH/HR).

Methods

A cross-sectional study (observational and exploratory) was conducted with 150 female reproductive-age workers and 41 DH/HR staff. They completed self-administered questionnaires, and responded to a semi-structured interview guide designed for the study. Participant observations were conducted in the BFR. Descriptive and inferential analyses were performed, considering statistical significance at p<0.05.

Results

Only 40 of the women of reproductive-age were aware of the existence of the BFR; and only one of the 20 who knew the specific location considered it to have proper conditions for milk extraction and storage. Between 21 and 28% of the participants considered that BF promotion actions were being conducted at the Institute. Although 61% of DH/HR reported knowing the existence of the BFR, the majority (80%) did not know if any female worker had used it.

Conclusions

Most of the Institute’s female workers of reproductive age did not know of the BFR’s existence, seldom used it, and said it lacked optimal conditions. Efforts to improve BFR conditions and functioning, as well as raise breastfeeding awareness at the workplace must be systematically promoted.

在工作场所创造有利于母乳喂养（BF）实践的环境是促进BF的有效途径。然而，很少有研究在墨西哥医疗保健机构中解决这一敏感和相关的主题。目的描述某三级卫生机构母乳喂养室（BFR）的条件和使用情况，并确定育龄女工、部门主管和人力资源工作人员（DH/HR）的看法。方法采用横断面研究（观察性和探索性）对150名育龄女工和41名卫生/人力资源工作人员进行调查。他们完成了自我管理的问卷，并回答了为研究设计的半结构化访谈指南。参与者在BFR中进行观察。进行描述性和推断性分析，考虑统计学显著性为p<；0.05。结果育龄妇女中仅有40人知晓BFR的存在；在知道具体地点的20人中，只有一人认为那里有合适的条件提取和储存牛奶。21%至28%的参与者认为该研究所正在开展男友推广活动。尽管61%的卫生保健/人力资源报告知道BFR的存在，但大多数（80%）不知道是否有女工使用过BFR。结论大多数育龄女工不知道BFR的存在，很少使用BFR，并表示BFR缺乏最佳条件。必须系统地促进改善BFR条件和功能以及提高工作场所母乳喂养意识的努力。

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引用次数: 0

Hot Topics in Gastroenterology and Hepatology 胃肠病学和肝病学热点话题。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-11-12 DOI: 10.1016/j.arcmed.2025.103347

Ludovico Abenavoli , Nahum Méndez-Sánchez

引用次数: 0

Challenges in Expanding the Donor Pool and Improving Long-Term Outcomes for Liver Transplantation 扩大供体池和改善肝移植长期预后的挑战。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-11-20 DOI: 10.1016/j.arcmed.2025.103348

Alberto Ferrarese , Sara Battistella , Francesca D’Arcangelo , Giuseppe Feltrin , Stefania Barbieri , Domenico Bassi , Alberto Zanetto , Giacomo Germani , Francesco Paolo Russo , Patrizia Burra

Liver transplantation is a curative treatment for many patients with end-stage liver disease, acute liver failure, and primary liver cancer when certain criteria are met. The persistent imbalance between organ availability and the number of patients on the waiting list presents both ethical and medical challenges in everyday clinical practice. Expanding the donor pool—and consequently increasing the number of retrieved grafts—requires action on multiple levels. These include raising awareness about organ donation, promoting willingness to donate, and increasing knowledge of post-transplant outcomes among the general population and healthcare professionals. In addition, organ acceptance criteria should be refined by incorporating recent advances in transplant hepatology and surgery. The survival benefit achieved through liver transplantation is well established for many conditions. To further improve long-term outcomes, more tailored and refined surveillance protocols are needed for the metabolic and neoplastic comorbidities that commonly develop after transplantation. In this updated literature review, we aim to highlight the main advances in these two crucial areas of liver transplantation.

肝移植是许多终末期肝病、急性肝衰竭和原发性肝癌患者在满足一定标准时的根治性治疗方法。器官供应和等待名单上的患者数量之间的持续不平衡在日常临床实践中提出了伦理和医学挑战。扩大供体池，从而增加移植的数量，需要在多个层面上采取行动。这些措施包括提高对器官捐赠的认识，促进捐赠意愿，增加普通人群和医疗保健专业人员对移植后结果的了解。此外，器官接受标准应结合移植肝病学和外科的最新进展加以完善。通过肝移植获得的生存益处在许多情况下都是公认的。为了进一步改善长期预后，需要针对移植后常见的代谢和肿瘤合并症制定更有针对性和更精细的监测方案。在这篇最新的文献综述中，我们旨在强调肝移植这两个关键领域的主要进展。

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引用次数: 0

Mechanism of SENP1-Mediated Regulation of Liver Sinusoidal Endothelial Cells to Promote Regeneration Via the HIF-1α Signaling Pathway senp1通过HIF-1α信号通路调控肝窦内皮细胞促进再生的机制

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-08-22 DOI: 10.1016/j.arcmed.2025.103295

Zhe Qing , Jian Duan , Qun Luo , Jinlan He , Hanfei Huang , Zhong Zeng

Background and Aims

Liver sinusoidal endothelial cells (LSECs) play a critical role in liver regeneration, but the specific molecular mechanism underlying this process remains unclear. Previous studies have shown that Sentrin/SUMO-specific protease 1 (SENP1) maintains the differentiation state of LSECs and promotes their proliferation under hypoxic conditions; however, the role of SENP1 in promoting liver regeneration by regulating LSECs is still unknown.

Methods

We employed a 70% hepatectomy (PHx) mouse model to explore the molecular mechanism underlying SENP1 regulation of LSECs and to observe the promotion of liver regeneration via the HIF-1α signaling pathway in vitro and in vivo.

Results

First, we found that the liver regeneration began on the first day after hepatectomy, while SENP1 expression in liver tissue was significantly upregulated. After SENP1 downregulation, the expression of Ki-67 and von Willebrand factor (vWF) in liver tissue decreased, as did the rate of liver regeneration. Second, in vitro, the proliferation activity of LSECs with SENP1 overexpression increased, and fenestration was better maintained. After co-culturing hepatocytes with LSECs that overexpress SENP1, an EdU assay showed that hepatocyte proliferation ability increased significantly. However, the opposite occurred when either a SENP1 or a HIF-1α inhibitor was used. In vivo, we observed that SENP1 can activate the VEGF/VEGFR2/Id1 signaling axis, upregulating the expression of VEGF and HGF through the HIF-1α signaling pathway, thus promoting hepatocyte proliferation and angiogenesis.

Conclusions

SENP1 may promote liver regeneration by regulating LSECs dependent on the HIF-1α signaling pathway.

背景和目的：肝窦内皮细胞（LSECs）在肝脏再生中起着关键作用，但这一过程的具体分子机制尚不清楚。先前的研究表明，Sentrin/ sumo特异性蛋白酶1 （SENP1）在缺氧条件下维持LSECs的分化状态，促进其增殖；然而，SENP1通过调节LSECs促进肝脏再生的作用尚不清楚。方法采用70%肝切除（PHx）小鼠模型，探讨SENP1调控LSECs的分子机制，并在体外和体内观察HIF-1α信号通路对肝脏再生的促进作用。结果首先，我们发现肝脏再生开始于肝切除术后第一天，肝组织中SENP1的表达显著上调。SENP1下调后，肝组织中Ki-67和血管性血变因子（vWF）的表达下降，肝脏再生率下降。其次，在体外，SENP1过表达的LSECs增殖活性增强，并且能更好地维持开窗状态。将肝细胞与过表达SENP1的LSECs共培养后，EdU检测显示肝细胞的增殖能力显著增强。然而，当使用SENP1或HIF-1α抑制剂时，情况正好相反。在体内，我们观察到SENP1可以激活VEGF/VEGFR2/Id1信号轴，通过HIF-1α信号通路上调VEGF和HGF的表达，从而促进肝细胞增殖和血管生成。结论senp1可能通过HIF-1α信号通路调控LSECs促进肝脏再生。

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引用次数: 0

Diagnostic Evaluation of Seronegative Celiac Disease 血清阴性乳糜泻的诊断评价。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.arcmed.2025.103338

Andrew Ford , Claire Jansson-Knodell , Alberto Rubio Tapia

Celiac disease (CeD) is an autoimmune condition that is traditionally characterized by the presence of serologic markers and flattening of the duodenal villi. However, a rare variant of the disease known as seronegative celiac disease (SNCeD), is characterized by an absence of these diagnostic serologies. The current diagnostic approach to this condition relies on excluding alternative seronegative enteropathies and confirming a positive CeD HLA genotype followed by an extended gluten-free diet (GFD). However, this current diagnostic approach is burdensome and underscores the need for more succinct methods. Encouragingly there are multiple tests that are being investigated for CeD diagnosis that also could extend to SNCeD diagnosis such as intestinal IgA anti-TG2 deposits, HLA-DQ tetramer assays, microRNA, interleukin-2, and flow cytometry among others.

乳糜泻（CeD）是一种自身免疫性疾病，传统上以血清学标志物和十二指肠绒毛变平为特征。然而，一种罕见的疾病变体，即血清阴性乳糜泻（SNCeD），其特征是缺乏这些诊断血清学。目前对这种疾病的诊断方法依赖于排除其他血清阴性肠病，并确认CeD HLA基因型阳性，然后延长无麸质饮食（GFD）。然而，目前的诊断方法是繁重的，并强调需要更简洁的方法。令人鼓舞的是，目前正在研究多种用于CeD诊断的检测方法，这些方法也可以扩展到SNCeD的诊断，如肠道IgA抗tg2沉积、HLA-DQ四聚体测定、microRNA、白细胞介素-2和流式细胞术等。

引用次数: 0

Global Burden of Peptic Ulcer Disease in Adolescents and Young Adults: Trends and Disparities from 1990–2021 青少年和年轻人消化性溃疡疾病的全球负担：1990-2021年的趋势和差异

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.arcmed.2025.103320

Tai Zhang , Beihua Zhang , Xudong Tang

Background

Peptic ulcer disease (PUD) significantly impacts adolescents and young adults (15–49 years), yet there are limited comprehensive analyses of its burden in this age group. This study examines global, regional, and national trends in PUD epidemiology from 1990–2021.

Methods

Using data from the 2021 Global Burden of Disease (GBD) Study, we analyzed PUD prevalence, incidence, disability-adjusted life years (DALYs), and mortality across 204 countries, stratified by age, sex, socio-demographic index (SDI), and GBD regions. Trends were quantified using estimated annual percentage changes (EAPC) and joinpoint regression.

Results

From 1990–2021, the global prevalence and incidence rates of PUD declined by 32.9 and 32.3%, respectively. Mortality and DALY rates decreased by 60.6 and 60.0%), respectively. Absolute cases increased by 50% in low SDI regions, while reductions were observed in middle SDI regions. South Asia and Western Sub-Saharan Africa had the highest prevalence rates. Sex disparities were evident, with males aged 45–49 having a prevalence rate that was 1.4-fold higher and a mortality rate that was 2.2-fold higher than females. Socioeconomic development inversely correlated with DALY rates (R = –0.708), but progress slowed after 2015 in high SDI regions.

Conclusions

The rising number of PUD cases in low SDI regions reflects population growth and limited healthcare access. Disparities highlight the need for targeted strategies. The slowed progress in high SDI regions indicates aging and evolving disease patterns. Tailored interventions are key for equitable control.

背景：消化性溃疡疾病（PUD）对青少年和年轻人（15-49岁）的影响显著，但对这一年龄组的负担的综合分析有限。本研究调查了1990-2021年全球、地区和国家PUD流行病学趋势。方法：使用2021年全球疾病负担（GBD）研究的数据，我们分析了204个国家的PUD患病率、发病率、残疾调整生命年（DALYs）和死亡率，并按年龄、性别、社会人口指数（SDI）和GBD地区进行了分层。使用估计的年百分比变化（EAPC）和连接点回归对趋势进行量化。结果：1990-2021年，全球PUD患病率和发病率分别下降了32.9%和32.3%。死亡率和DALY分别下降60.6%和60.0%。在低SDI地区，绝对病例增加了50%，而在中等SDI地区则减少了。南亚和西撒哈拉非洲的患病率最高。性别差异很明显，45-49岁男性的患病率比女性高1.4倍，死亡率比女性高2.2倍。社会经济发展与DALY率呈负相关（R = -0.708），但在2015年之后，高SDI地区的社会经济发展放缓。结论：低SDI地区PUD病例数的上升反映了人口增长和医疗保健服务的有限性。差距突出表明需要有针对性的战略。在高SDI区域，进展缓慢表明了衰老和疾病模式的演变。量身定制的干预措施是公平控制的关键。

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引用次数: 0

Non-Invasive Testing in Metabolic Dysfunction Associated Fatty Liver Disease 代谢功能障碍相关脂肪性肝病的无创检测。

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-10-31 DOI: 10.1016/j.arcmed.2025.103337

Cameron Gofton , Jacob George

Since the introduction of non-alcoholic steatohepatitis into the medical nomenclature, liver biopsy has been the best option for diagnosis, despite multiple limitations. Due to this inaccurate gold standard, there has been a need to develop non invasive testing for this disease to better diagnose and stage this condition. With the development of new terminology in 2020 of metabolic-dysfunction associated fatty liver disease providing a positive diagnostic criterion followed by metabolic-dysfunction associated steatotic liver disease, there has been extensive work to transition existing biomarkers into these new conditions. Despite this, there remains current gaps in biomarker development to meet the needs of this condition, particularly in view of its worldwide increasing prevalence. In this narrative review, we summarise the current concepts of non-invasive testing, review the available biomarkers and their accuracy in steatosis, steatohepatitis, and fibrosis, and discuss future concepts of biomarker development.

自从将非酒精性脂肪性肝炎引入医学术语以来，肝活检一直是诊断的最佳选择，尽管存在多种限制。由于这种不准确的金标准，有必要为这种疾病开发非侵入性测试，以更好地诊断和分期这种疾病。随着2020年代谢功能障碍相关脂肪性肝病新术语的发展，为代谢功能障碍相关脂肪性肝病提供了积极的诊断标准，人们已经开展了广泛的工作，将现有的生物标志物转化为这些新病症。尽管如此，目前在生物标志物开发方面仍存在差距，以满足这种情况的需求，特别是考虑到其在世界范围内日益普遍。在这篇叙述性综述中，我们总结了目前无创检测的概念，回顾了脂肪变性、脂肪性肝炎和纤维化中可用的生物标志物及其准确性，并讨论了生物标志物发展的未来概念。

引用次数: 0

Probiotics for the Management of Liver Cirrhosis and Its Complications 益生菌治疗肝硬化及其并发症

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.arcmed.2025.103304

Junxiu Chen , Haonan Zhao , Nahum Méndez-Sánchez , Xingshun Qi

Cirrhosis is the terminal stage of various chronic liver diseases, and its decompensated stage is mainly characterized by serious complications, such as hepatic encephalopathy, ascites, spontaneous bacterial peritonitis, and gastrointestinal bleeding. Gut microbial dysbiosis is prevalent in patients with cirrhosis. Considering the bidirectional regulation of the gut-liver axis, dysbiosis is closely related to the development and progression of liver cirrhosis. Probiotics, which modulate the gut microbiome, have received significant attention for managing cirrhosis and its complications. Through a review of relevant literature, we have provided a comprehensive summary of the potential efficacy of probiotics in treating cirrhosis and its complications, providing new insights into targeting the gut microbiome.

肝硬化是各种慢性肝病的终末阶段，其失代偿期主要表现为严重的并发症，如肝性脑病、腹水、自发性细菌性腹膜炎、胃肠道出血等。肝硬化患者普遍存在肠道微生物失调。考虑到肠肝轴的双向调节，生态失调与肝硬化的发生发展密切相关。调节肠道微生物群的益生菌在治疗肝硬化及其并发症方面受到了极大的关注。通过对相关文献的回顾，我们全面总结了益生菌治疗肝硬化及其并发症的潜在疗效，为靶向肠道微生物群提供了新的见解。

引用次数: 0

Metabolic Dysfunction-Associated Steatohepatitis in Focus: Pathogenesis, Non-Invasive Diagnostics, and Future Approaches 代谢功能障碍相关脂肪性肝炎的焦点：发病机制，非侵入性诊断和未来的方法

IF 3.4 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-12-01 Epub Date: 2025-11-29 DOI: 10.1016/j.arcmed.2025.103350

Abdulrahman Ismaiel , Mhd Bashir Almonajjed , Cristina Sorina Catana , Stefan-Lucian Popa , Dan L. Dumitrascu

Metabolic dysfunction-associated steatohepatitis (MASH) has become a critical public health concern, representing the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD). MASH is characterized by hepatic steatosis, inflammation, hepatocyte ballooning, and fibrosis, which increase the risk of cirrhosis and hepatocellular carcinoma. Closely linked to obesity, insulin resistance, and metabolic syndrome, MASH affects a significant proportion of the global population, requiring accurate diagnostic tools and tailored interventions. This manuscript delves into the current understanding of MASH, focusing on its pathophysiology, diagnostic challenges, and innovative non-invasive strategies. While liver biopsy remains the gold standard for diagnosis, its invasiveness and limitations have prompted the search for alternative approaches. Promising non-invasive techniques, such as elastography, MRI-based techniques, and serum biomarkers like cytokeratin-18, NIS4, and FAST scores, provide new ways to detect MASH and evaluate fibrosis severity. The updated MASLD criteria refine risk stratification further, capturing a broader range of at-risk individuals, including lean phenotypes. As MASH continues to strain healthcare systems worldwide, this review underscores the importance of advancing non-invasive diagnostics and integrating multi-omics approaches. Future research should focus on developing personalized strategies to halt disease progression, enhance early detection, and optimize patient outcomes.

代谢功能障碍相关脂肪性肝炎（MASH）已成为一个重要的公共卫生问题，代表了代谢功能障碍相关脂肪性肝病（MASLD）的进行性形式。MASH的特点是肝脂肪变性、炎症、肝细胞球囊化和纤维化，这些都增加了肝硬化和肝细胞癌的风险。MASH与肥胖、胰岛素抵抗和代谢综合征密切相关，影响着全球很大一部分人口，需要准确的诊断工具和量身定制的干预措施。这份手稿深入到目前对MASH的理解，侧重于其病理生理学，诊断挑战和创新的非侵入性策略。虽然肝活检仍然是诊断的金标准，但其侵入性和局限性促使人们寻找替代方法。有前途的非侵入性技术，如弹性成像、基于mri的技术和血清生物标志物，如细胞角蛋白-18、NIS4和FAST评分，提供了检测MASH和评估纤维化严重程度的新方法。更新的MASLD标准进一步细化了风险分层，捕获了更广泛的高危个体，包括瘦表型。随着MASH继续给全球医疗保健系统带来压力，本综述强调了推进非侵入性诊断和整合多组学方法的重要性。未来的研究应侧重于制定个性化的策略，以阻止疾病的进展，加强早期发现，并优化患者的预后。

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