Archives of Medical Research最新文献_第9页

Knowledge, Attitudes and Practices Regarding COVID-19 and Its Vaccination in a High School Population 高中人群关于COVID-19及其疫苗接种的知识、态度和做法

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-27 DOI: 10.1016/j.arcmed.2025.103241

Mauricio Rodríguez-Álvarez , Luis Pablo Cruz-Hervert , María Eugenia Jiménez-Corona , Norma Mongua-Rodríguez , María Dolores Valle Martínez , Benjamín Barajas Sánchez , Javier Romero y Fuentes , Lourdes García-García , Samuel Ponce-de-León-Rosales

Background

The coronavirus disease 2019 (COVID-19) pandemic had a profound impact on education in Mexico, with extended school closures and the shift to distance learning. The absence of an initial vaccine and the general need for evidence on prevention measures within university communities prompted this study.

Objective

To assess the knowledge, attitudes, and practices regarding COVID-19 and its vaccination in the high school community (HSC) of the National Autonomous University of Mexico (UNAM) by the third year of the pandemic.

Methods

A cross-sectional, 26-question online survey was conducted among UNAM HSC in September 2022. The data were analyzed using multivariate logistic and linear regression models to identify factors associated with vaccination.

Results

A total of 22,000 surveys were collected, 16,789 of which were eligible for analysis. Among these, 16,361 (97.4 %) respondents were vaccinated. The primary reason for nonvaccination was the inability to access a vaccine (37.2 %). Younger respondents (<18 years) were more likely to be unvaccinated, 10–14 years, (OR: 5.36; 95 % CI: 2.12–13.55; p < 0.001); and 15–18 years, (OR: 2.77; 95 % CI: 1.12–6.82, p = 0.028). Individuals with overweight/obesity (OR: 1.39; 95 % CI 1.05–1.85; p = 0.023); immunosuppression (OR: 2.6; 95 % CI: 1.56–4.33; p < 0.001), and those who considered these conditions as risk factors for COVID-19 were significantly more likely to be unvaccinated. Conversely, those who viewed hypertension as a risk factor OR 0.7 (95 % CI 0.53–0.93)) or who were accustomed to face mask use OR 0.28 (95 % CI 0.22–0.35), p < 0.001) were more likely to be vaccinated.

Conclusions

We found a high acceptance of COVID-19 vaccination at UNAM HSC, which may have contributed to the safer resumption of in-person activities and helped mitigate the impact of subsequent epidemic waves; the reasons for non-vaccination appear addressable through targeted logistical measures and tailored information.

2019年冠状病毒病（COVID-19）大流行对墨西哥的教育产生了深远影响，学校停课时间延长，并转向远程教育。缺乏最初的疫苗和对大学社区预防措施证据的普遍需求促使了这项研究。目的评估墨西哥国立自治大学（UNAM）高中社区（HSC）在大流行第三年时对COVID-19及其疫苗接种的知识、态度和做法。方法于2022年9月对UNAM HSC进行了一项包含26个问题的横断面在线调查。使用多变量逻辑和线性回归模型对数据进行分析，以确定与疫苗接种相关的因素。结果共收集调查问卷2.2万份，其中符合分析条件的调查问卷16789份。其中，16361人（97.4%）接种了疫苗。未接种疫苗的主要原因是无法获得疫苗（37.2%）。较年轻的应答者（18岁）更有可能未接种疫苗，10-14岁，(OR: 5.36；95% ci: 2.12-13.55；p & lt;0.001);15-18岁，(OR: 2.77；95% CI: 1.12-6.82, p = 0.028)。超重/肥胖个体(OR: 1.39；95% ci 1.05-1.85；P = 0.023)；免疫抑制(OR: 2.6；95% ci: 1.56-4.33；p & lt;0.001)，而那些认为这些情况是COVID-19危险因素的人更有可能未接种疫苗。相反，将高血压视为危险因素的患者OR为0.7 (95% CI 0.53-0.93)，或习惯使用口罩的患者OR为0.28 (95% CI 0.22-0.35), p <；0.001)更有可能接种疫苗。结论新冠肺炎疫苗接种的接受度较高，这可能有助于更安全地恢复现场活动，并有助于减轻后续流行浪潮的影响；不接种疫苗的原因似乎可以通过有针对性的后勤措施和量身定制的信息来解决。

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引用次数: 0

Changing Landscape of Liver Cirrhosis Etiologies 肝硬化病因的变化趋势

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-27 DOI: 10.1016/j.arcmed.2025.103240

Nahum Méndez-Sánchez , Mariana M Ramírez-Mejía , Ming-Hua Zheng , Carlos Cortez-Hernández , Elianee M Tovar-Bojorquez , Raúl Contreras-Omaña , Juan D Monsiváis-Morales , Jacqueline Córdova-Gallardo , Mauricio Castillo-Barradas , Nubia Guzmán-Rodríguez , María S González-Huezo , Adrian Sandez-Araiza , Eira Cerda-Reyes , Stefanny Cornejo-Hernández , Beatriz Barranco-Fragoso , Ana D Cano-Contreras , José M Remes-Troche , Fatima Higuera-de-la-Tijera , José L Pérez-Hernández , Norberto Chávez-Tapia , Heriberto Rodríguez-Hernández

Background and Aims

Liver cirrhosis is a major public health problem worldwide. In Mexico, the increased prevalence of obesity and type 2 diabetes mellitus (T2DM) has contributed to an increase in the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). This study examines the current etiologies of cirrhosis in Mexico, highlighting regional and demographic differences.

Methods

We conducted a multicenter cross-sectional study of 2182 patients with cirrhosis diagnosed between 2018 and 2024 in 13 tertiary care hospitals in northern, central, and southern Mexico. Demographic data, etiology, and complications were analyzed.

Results

MASLD was the most frequent cause of cirrhosis (42.8 %), followed by alcohol-related liver disease (ALD, 23.8 %) and hepatitis C virus (HCV, 12.2 %). MASLD was more common in older patients and women, while ALD was more frequent in younger patients and men. HCC was observed in 8.9 % of patients, with a higher prevalence in the central region. The most common complications were portal hypertension (59.5 %) and ascites (30.4 %). Regional differences were observed, with a higher prevalence of MASLD in central and southern Mexico, while ALD was more prominent in the northern region.

Conclusion

This cross-sectional study underscores the changing etiologies of liver cirrhosis in Mexico, with MASLD emerging as the leading cause, particularly in older patients and women. Regional differences were evident, with ALD being more frequent in younger patients and in men, especially in the northern region.

背景和目的肝硬化是世界范围内的一个主要公共卫生问题。在墨西哥，肥胖和2型糖尿病（T2DM）患病率的增加导致了代谢功能障碍相关脂肪变性肝病（MASLD）患病率的增加。本研究考察了目前墨西哥肝硬化的病因，强调了区域和人口差异。方法：我们对墨西哥北部、中部和南部13家三级医院2018年至2024年间诊断为肝硬化的2182例患者进行了一项多中心横断面研究。对人口统计资料、病因及并发症进行分析。结果smasld是肝硬化最常见的原因（42.8%），其次是酒精相关性肝病（ALD, 23.8%）和丙型肝炎病毒（HCV, 12.2%）。MASLD在老年患者和女性中更为常见，而ALD在年轻患者和男性中更为常见。在8.9%的患者中观察到HCC，中部地区的患病率较高。最常见的并发症是门静脉高压（59.5%）和腹水（30.4%）。观察到区域差异，墨西哥中部和南部的MASLD患病率较高，而ALD在北部地区更为突出。这项横断面研究强调了墨西哥肝硬化病因的变化，MASLD成为主要原因，特别是在老年患者和女性中。地区差异很明显，ALD在年轻患者和男性中更为常见，特别是在北部地区。

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引用次数: 0

Response to: “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study” 对《癌症患者感染性心内膜炎的临床特征和结局：一项多中心病例对照研究》的回应

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-23 DOI: 10.1016/j.arcmed.2025.103233

Gustavo Méndez-Hirata , Frida Rivera-Buendía , Eduardo Viveros-Rentería , Eric Ochoa-Hein , Patricia Cornejo-Juárez , Manlio Márquez , Jose Ramón Hidalgo-Dura , Yoana Leyva-López , Diana Vilar-Compte

引用次数: 0

Declaration of Helsinki 2024: Advances and Persistent Setbacks From a Latin American and Caribbean Bioethical Perspective 2024年赫尔辛基宣言：从拉丁美洲和加勒比生物伦理的角度看进展和持续的挫折

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-21 DOI: 10.1016/j.arcmed.2025.103237

Fernando Hellmann , Susana M. Vidal , Claude Vergès , Constanza Ovalle , Diego Fonti , Gabriela Minaya , Ignacio Maglio , Luis Manuel López Dávila , Maria Virginia Rodriguez Funes , Marianela Barcia , Martha Marcela Rodríguez Alanís , Marta Ascura , Thiago Rocha Da Cunha , Xiomara Bu , Volnei Garrafa , José Ramón Acosta Sariego

引用次数: 0

A Comprehensive Review of Behcet’s Disease Damage Assessment Tools 白塞病损害评估工具综述

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-20 DOI: 10.1016/j.arcmed.2025.103238

Alireza Khabbazi , Ehsan Mehrtabar , Saba Mehrtabar , Amirreza Khalaji , Aida Malek Mahdavi

Outcome assessment of rheumatic diseases has a significant role in evaluating the effect of various therapies in clinical studies and in the treatment of these patients in daily practice. Outcome assessment in rheumatic disorders is based on the evaluation of disease activity, quality of life, disability, and mortality caused by the disease. Behçet’s disease (BD) is a multisystem inflammatory condition that can cause damage to multiple organs. Damage assessment, along with assessment of BD activity, are two necessary and complementary components of BD outcome measures, based on Outcome Measures in Rheumatology. In clinical trials of BD, outcome assessment has been based on disease activity measures, which do not measure damage severity. In this review, we considered three damage indices that have recently been introduced to assess BD-related injury, including vasculitis damage index (VDI), Behçet’s syndrome overall damage index (BODI), and Behçet’s disease damage index (BDI).

风湿性疾病的结局评估在临床研究和日常治疗中对各种治疗方法的疗效评价中具有重要作用。风湿性疾病的结局评估是基于疾病活动性、生活质量、残疾和由疾病引起的死亡率的评估。behet病（BD）是一种多系统炎症性疾病，可引起多器官损伤。损害评估和BD活动评估是基于《风湿病学结果测量》的BD结果测量的两个必要和互补的组成部分。在双相障碍的临床试验中，结果评估是基于疾病活动度测量，而不是测量损害的严重程度。在这篇综述中，我们考虑了最近引入的用于评估bd相关损伤的三种损伤指标，包括血管炎损伤指数（VDI）、behet综合征整体损伤指数（BODI）和behet病损伤指数（BDI）。

引用次数: 0

Diabetes Mellitus Impairs the Bone Regeneration Capacity of Mesenchymal Stromal Cell-Based Therapy 糖尿病损害间充质间质细胞治疗的骨再生能力

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-20 DOI: 10.1016/j.arcmed.2025.103234

Alann Thaffarell Portilho Souza , Gileade Pereira Freitas , Helena Bacha Lopes , Denise Weffort , Leticia Faustino Adolpho , Maria Paula Oliveira Gomes , Fabiola Singaretti Oliveira , Adriana Luisa Gonçalves Almeida , Marcio Mateus Beloti , Adalberto Luiz Rosa

Background

Diabetes mellitus (DM) negatively impacts bone tissue, leading to bone loss and increased fracture risk. Many individuals need additional treatments, and therapy based on mesenchymal stromal cells (MSCs) represents a promising treatment for bone defects in patients with diabetes.

Aims

The present study explored the effects of interactions between MSCs from normoglycemic (NG-MSCs) and diabetic (DM-MSCs) donors on osteoblast differentiation and the effects of cell therapy using NG-MSCs on bone regeneration in defects created in diabetic rats.

Methods

After inducing DM with streptozotocin, we evaluated the morphometric parameters of rat femurs and the osteoblast differentiation of MSCs, as well as the effects of the interaction between NG-MSCs and DM-MSCs on their osteoblast differentiation. The efficacy of cell therapy was measured by evaluating the bone repair in calvarial defects of diabetic rats treated with local injections of either NG-MSCs or a vehicle.

Results

DM induced bone loss and impaired the osteoblast differentiation of MSCs, which was partially restored by NG-MSCs, while the bone formation observed in defects treated with NG-MSCs and the vehicle was similar.

Conclusion

These results indicate that the beneficial effect of NG-MSCs on DM-MSCs did not translate into enhanced bone repair, mainly due to a hostile environment created by hyperglycemia, which compromised the ability of MSCs to induce bone formation.

糖尿病（DM）对骨组织产生负面影响，导致骨质流失和骨折风险增加。许多个体需要额外的治疗，基于间充质间质细胞（MSCs）的治疗是治疗糖尿病患者骨缺损的一种很有希望的治疗方法。目的本研究探讨了来自正常血糖（NG-MSCs）和糖尿病（DM-MSCs）供体的间充质干细胞相互作用对成骨细胞分化的影响，以及使用NG-MSCs进行细胞治疗对糖尿病大鼠骨缺损再生的影响。方法采用链脲佐菌素诱导DM后，观察大鼠股骨形态计量学参数和MSCs的成骨分化情况，以及NG-MSCs和DM-MSCs相互作用对其成骨分化的影响。通过观察局部注射NG-MSCs或载体对糖尿病大鼠颅骨缺损的骨修复效果，观察细胞治疗的效果。结果dm诱导骨丢失，MSCs成骨分化受损，NG-MSCs能部分恢复成骨分化，而NG-MSCs处理的缺损骨形成与对照相似。这些结果表明，NG-MSCs对DM-MSCs的有益作用并没有转化为增强骨修复，这主要是由于高血糖造成的不利环境损害了MSCs诱导骨形成的能力。

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引用次数: 0

Comment on “Clinical Characteristics and Outcomes of Infective Endocarditis in Patients With Cancer: A Multicenter Case-Control Study” 《癌症患者感染性心内膜炎的临床特点和结局：一项多中心病例对照研究》评论

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-19 DOI: 10.1016/j.arcmed.2025.103232

Hamidreza Zivarifar , Ali Kamali , Masoud Keikha

引用次数: 0

Evaluation of Multimorbidity Burden in Frailty Transitions in Costa Rican Older Adults Using Multistate Markov Models 使用多状态马尔可夫模型评估哥斯达黎加老年人衰弱过渡中的多重疾病负担

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-14 DOI: 10.1016/j.arcmed.2025.103230

Rafael Ogaz-González , Postmus D , Ricardo Escamilla-Santiago , Luis Miguel Gutiérrez-Robledo , Malaquías López-Cervantes , Eva Corpeleijn

Background and Aims

The accumulation of non-communicable chronic diseases is recognized to play a crucial role in the deterioration of health in older adults, partly because it may impact frailty states. This study assessed the influence of multimorbidity on the phenotype transitions in frailty over time and frailty-related mortality risk.

Methods

Data from the Costa Rican Longevity and Healthy Aging Study Cohort (2005–2010) was used. A total of 2660 individuals aged 60 and above were included. Multimorbidity was defined as having three or more non-communicable diseases from 13 chronic conditions. Fried criteria were employed to assess frailty states (robust, pre-frail, frail). Markov-based multistate models were used to examine the impact of multimorbidity on frailty transitions and mortality over 5 years.

Results

Multimorbidity accelerates the transition to frailty. Compared to those with fewer than three non-communicable diseases, individuals with both multimorbidity and a prefrail state had a lower chance of recovering to robustness (HR:0.73 [95% CI: 0.54–0.99]), and a higher risk of becoming frail (HR:1.83 [95% CI: 1.43–2.34]). This translates into a 30-month earlier onset of frailty compared to individuals without chronic diseases. Multimorbidity increased the risk of all-cause mortality in those who were pre-frail (HR:1.83 [95% CI: 1.43–2.34]) but did not affect mortality risk in those who were already frail (HR:0.88 [95% CI: 0.62–1.23]).

Conclusions

Multimorbidity is a predictor for dynamic transitions to frailty or death. It favors the transition to “Frailty” more than to death and impacts mortality mostly in people with a “Pre-frail” state, encouraging them to explore opportunities for intervention.

背景和目的非传染性慢性疾病的积累被认为在老年人健康恶化中起着至关重要的作用，部分原因是它可能影响虚弱状态。本研究评估了多病对衰弱表型转变的影响，以及衰弱相关的死亡风险。方法采用哥斯达黎加长寿与健康老龄化研究队列（2005-2010）的数据。调查共包括2660名60岁及以上人士。多病定义为患有13种慢性病中的3种或3种以上非传染性疾病。采用油炸标准来评估虚弱状态（健壮，虚弱前，虚弱）。使用基于马尔可夫的多状态模型来检查5年多发病对衰弱转变和死亡率的影响。结果慢性疾病加速了向衰弱的过渡。与患有少于三种非传染性疾病的人相比，同时患有多种疾病和体弱多病的人恢复强健的机会较低（相对危险度：0.73 [95% CI: 0.54-0.99]），而体弱多病的风险较高（相对危险度：1.83 [95% CI: 1.43-2.34]）。与没有慢性疾病的人相比，这意味着身体虚弱的发病时间提前了30个月。多病增加了体弱前患者的全因死亡率（HR:1.83 [95% CI: 1.43-2.34]），但不影响体弱患者的死亡率（HR:0.88 [95% CI: 0.62-1.23]）。结论多重发病率是动态过渡到虚弱或死亡的预测因子。它更倾向于向“虚弱”过渡，而不是向死亡过渡，对死亡率的影响主要发生在“虚弱前”状态的人身上，鼓励他们探索干预的机会。

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引用次数: 0

Single Nucleotide Variants of the SLC2A9 Gene are Associated With Hyperuricemia in Mexican Patients With Type 2 Diabetes SLC2A9基因的单核苷酸变异与墨西哥2型糖尿病患者的高尿酸血症有关

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-14 DOI: 10.1016/j.arcmed.2025.103235

Gloria Elizabeth Vázquez-Rivera , Erika F. Gómez-García , Renato Parra-Michel , Rosalba Orozco-Sandoval , Lourdes del Carmen Rizo-de la Torre , Caridad A. Leal-Cortés , Claudia Nayeli Contreras-Aceves , Mariana Pérez-Coria , Alfonso Farías-Basulto , Francisco Mendoza-Carrera

Background

Chronic kidney disease (CKD) due to diabetes is the third leading cause of death in Mexico. A relationship between high serum uric acid (SUA) levels and kidney disease have been demonstrated. On the other hand, variants of the SLC2A9 gene have been associated with elevated SUA concentrations. This study evaluated the associations of the rs11722228, rs3775948, rs7678287, and rs1014290 variants with hyperuricemia and biochemical parameters in patients with type 2 diabetes (T2D).

Methods

The study included 1036 Mexican subjects with T2D. Patients were grouped based on the presence (n = 462) or absence (n = 574) of diabetic kidney disease (DKD). SUA concentrations and biochemical parameters were determined. Samples were genotyped through real-time polymerase chain reaction. Associations between genetic variants and hyperuricemia were analyzed by univariate and multivariate models adjusting for covariates.

Results

SUA levels and hyperuricemia prevalence were higher in the DKD group. rs3775948 and rs1014290 showed negative associations with hyperuricemia in the whole sample and in patients without DKD. rs7678287 was positively correlated with SUA and hyperuricemia in patients without DKD, whereas rs11722228 was a risk factor only in the DKD group. The presence of DKD and elevated triglycerides and total cholesterol were significant factors associated with hyperuricemia.

Conclusions

Variants rs3775948 and rs1014290 exhibit protective effects, while rs7678287 and rs11722228 may confer increased risk of hyperuricemia in Mexican patients with T2D. Analysis of SLC2A9 gene variants could help in detecting patients at increased risk of kidney or cardiovascular complications due to hyperuricemia.

背景：糖尿病引起的慢性肾脏疾病（CKD）是墨西哥第三大死亡原因。高血清尿酸（SUA）水平与肾脏疾病之间的关系已得到证实。另一方面，SLC2A9基因的变异与SUA浓度升高有关。本研究评估了rs11722228、rs3775948、rs7678287和rs1014290变异与2型糖尿病（T2D）患者高尿酸血症和生化参数的关系。方法纳入墨西哥T2D患者1036例。根据存在（n = 462）或不存在（n = 574）糖尿病肾病（DKD）对患者进行分组。测定SUA浓度及生化指标。通过实时聚合酶链反应对样品进行基因分型。通过调整协变量的单变量和多变量模型分析遗传变异与高尿酸血症之间的关系。结果DKD组的sua水平和高尿酸血症发生率较高。rs3775948和rs1014290与全样本和无DKD患者的高尿酸血症呈负相关。rs7678287与无DKD患者的SUA和高尿酸血症呈正相关，而rs11722228仅在DKD组中是危险因素。DKD、甘油三酯和总胆固醇升高是与高尿酸血症相关的重要因素。结论变异rs3775948和rs1014290具有保护作用，而rs7678287和rs11722228可能会增加墨西哥T2D患者高尿酸血症的风险。对SLC2A9基因变异的分析有助于发现高尿酸血症引起的肾脏或心血管并发症风险增加的患者。

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引用次数: 0

Human Voltage-Activated H+ Channel is Highly Expressed in Acute Myeloid Leukemia and is Associated With the Blast Differentiated Stage 人电压激活H+通道在急性髓系白血病中高表达并与细胞分化阶段相关

IF 4.7 3区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Archives of Medical Research

Pub Date : 2025-05-13 DOI: 10.1016/j.arcmed.2025.103221

Diego Issouribehere , Nicolás Enrique , Paulina Finochietto , Juan Ignacio Felice , Carolina Belli , Clara Ventura , Verónica Milesi

Background

In acute myeloid leukemia (AML), hematopoietic precursors of myeloid cells proliferate rapidly but are arrested at an early stage, impeding their maturation and normal function. The human voltage-activated proton channel (hHv1) is a membrane protein with important roles in myeloid phagocytic cells. This work aimed to evaluate the expression of hHv1 channel as a novel biological marker associated with the process of cell differentiation in AML.

Methods

In this study, we evaluated the expression of the hHv1, at both mRNA and protein levels in AML.

Results

We demonstrated that the expression of hHv1 is upregulated at both mRNA and protein levels in AML. Moreover, our results indicate that hHv1 expression correlates with the degree of monocytic differentiation in AML cells in a pattern similar to that previously reported for NADPH oxidase (NOX2), a relevant cellular structure functionally coupled to the hHv1 channel. However, while increases in NOX2 components have not been associated with improved prognosis or survival, we found that the hHv1 upregulation was associated with better prognosis and survival outcomes.

Conclusions

These results suggest that hHv1 may serve as a novel biomarker for favorable prognosis in AML and may represent a promising therapeutic target.

在急性髓性白血病（AML）中，骨髓细胞的造血前体增殖迅速，但在早期阶段被抑制，阻碍了它们的成熟和正常功能。人电压激活质子通道（hHv1）是一种在骨髓吞噬细胞中起重要作用的膜蛋白。本工作旨在评估hHv1通道作为AML细胞分化过程相关的新生物标志物的表达。方法在本研究中，我们评估了hHv1在AML中mRNA和蛋白水平的表达。结果我们证实hHv1在AML中mRNA和蛋白水平的表达上调。此外，我们的研究结果表明，hHv1的表达与AML细胞的单核细胞分化程度相关，其模式与先前报道的NADPH氧化酶（NOX2）相似，后者是一种与hHv1通道功能偶联的相关细胞结构。然而，虽然NOX2成分的增加与预后或生存改善无关，但我们发现hHv1上调与更好的预后和生存结果相关。结论hHv1可能是AML患者预后良好的一种新的生物标志物，可能是一个有前景的治疗靶点。

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引用次数: 0