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Determinants of 6-month mortality in super-old patients with femoral neck fractures: the role of surgery and preoperative status in Japan 日本高龄股骨颈骨折患者6个月死亡率的决定因素:手术和术前状态的作用
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-24 DOI: 10.1007/s00402-025-06095-1
Tetsuro Tani, Makoto Kitade, Ai Takahashi, Seiji Okada, Akihiko Matsumine
AbstractSection Introduction

The number of individuals aged > 90 years (super-old) is steadily increasing, along with the incidence of femoral neck fractures. Surgical treatment in patients aged > 85 years is associated with a high risk of complications, and in super-old patients, surgical intervention is particularly challenging because of multiple comorbidities. However, data on mortality without surgery and its associated factors in this age group are lacking. This study aimed to (1) evaluate the 6-month mortality rate following femoral neck fractures in super-old patients and (2) identify factors associated with 6-month mortality following injury.

AbstractSection Materials and methods

This retrospective study included patients aged > 90 years admitted to our hospital with femoral neck fractures between April 2010 and March 2021, with at least 6 months of follow-up. We collected data on demographics, fracture type, preinjury ambulatory function, treatment type (surgical or non-surgical), and admission laboratory data. Patients were grouped by survival status at 6 months after injury, and mortality rates and associated predictive factors were analyzed.

AbstractSection Results

A total of 76 patients were included in the study (non-surgical group, n = 37; surgical group, n = 39). The cohort included 14 men and 62 women, with a mean age of 91.9 years (range, 90–96 years). The overall 6-month mortality rate was 21.0% (16/76), with higher mortality in the non-surgical group (40.5%) than in the surgical group (2.5%). Significant predictors of 6-month mortality were pre-injury ambulatory function and serum albumin levels at admission.

AbstractSection Conclusion

In super-old patients with femoral neck fractures, the 6-month mortality rate is approximately 20%, increasing to 40% in the absence of surgical treatment. Poor preinjury ambulatory function and low albumin levels were significant predictors of mortality. These findings highlight the importance of surgical treatment and pre-operative assessments in this population.

【摘要】章节简介随着股骨颈骨折的发生,90岁高龄(超高龄)患者数量稳步增加。85岁患者的手术治疗与并发症的高风险相关,而对于高龄患者,由于多种合并症,手术干预尤其具有挑战性。然而,该年龄组未手术死亡率及其相关因素的数据缺乏。本研究旨在(1)评估超高龄患者股骨颈骨折后6个月的死亡率,(2)确定损伤后6个月死亡率的相关因素。【摘要】资料与方法本研究纳入2010年4月至2021年3月我院收治的90岁股骨颈骨折患者,随访至少6个月。我们收集了人口统计学、骨折类型、伤前动态功能、治疗类型(手术或非手术)和入院实验室数据的数据。根据损伤后6个月的生存状况对患者进行分组,并分析死亡率及相关预测因素。【摘要】本研究共纳入76例患者,其中非手术组37例,手术组39例。该队列包括14名男性和62名女性,平均年龄91.9岁(范围90-96岁)。总6个月死亡率为21.0%(16/76),非手术组死亡率(40.5%)高于手术组(2.5%)。损伤前的动态功能和入院时的血清白蛋白水平是6个月死亡率的重要预测因子。【摘要】结论超高龄股骨颈骨折患者6个月死亡率约为20%,若不进行手术治疗,死亡率可达40%。损伤前运动功能差和低白蛋白水平是死亡率的重要预测因素。这些发现强调了手术治疗和术前评估在这一人群中的重要性。
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引用次数: 0
Similar clinical and survival outcomes between robotic-assisted cemented and cementless total knee arthroplasty 机器人辅助骨水泥和无骨水泥全膝关节置换术的临床和生存结果相似
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-24 DOI: 10.1007/s00402-025-06100-7
Umberto Vitale, Matteo Agarossi, Luca Ruosi, Ferdinando De Dona, Mattia Loppini, Federico D’Amario
AbstractSection Background

Cemented fixation remains the standard in total knee arthroplasty (TKA), but cementless techniques are gaining popularity, particularly in younger, more active patients. Robotic assistance may improve the accuracy of cementless implantation and promote favorable outcomes.

AbstractSection Methods

A retrospective review was conducted of 130 cruciate-retaining primary TKAs performed using the ROSA® robotic-assisted system between October 2021 and September 2023 by a single high-volume surgeon. Patients received either a cementless Persona Trabecular Metal® (n = 80) or cemented Persona® (n = 50) prosthesis. Patient demographics, perioperative data, complications, and revisions were recorded. Patient-reported outcome measures (PROMs) WOMAC, Oxford Knee Score, Knee Society Score, and Forgotten Joint Score-12 were collected preoperatively and at minimum one-year follow-up.

AbstractSection Results

Patients in the cementless group were younger (p < 0.001) and more frequently men (p = 0.003). Both groups showed significant improvement in all PROMs from baseline (p < 0.001), with no statistically significant differences in final PROMs between groups. One revision occurred in the cemented group (2.0%) due to stiffness and pain; two manipulations under anesthesia (MUA) were required in the cementless group (2.5%). No differences were observed in operative time or hospital length of stay.

AbstractSection Conclusion

At short-term follow-up, cementless and cemented robotic-assisted TKAs demonstrated equivalent improvements in PROMs and survivorship. Cementless implants may represent a viable option in appropriately selected patients, particularly younger individuals, when combined with robotic precision. Long-term data are needed to confirm durability.

摘要背景骨水泥固定仍然是全膝关节置换术(TKA)的标准,但无骨水泥技术越来越受欢迎,特别是在年轻、更活跃的患者中。机器人辅助可以提高无骨水泥植入的准确性,促进良好的结果。【摘要】【章节方法】回顾性分析了2021年10月至2023年9月期间由一名高容量外科医生使用ROSA®机器人辅助系统进行的130例保留十字架的初级tka。患者接受无骨水泥假体Persona小梁金属®(n = 80)或骨水泥假体Persona®(n = 50)。记录患者人口统计资料、围手术期资料、并发症和修订情况。术前和至少1年的随访收集患者报告的结果测量(PROMs) WOMAC、牛津膝关节评分、膝关节社会评分和遗忘关节评分-12。【摘要】【章节】结果无骨水泥组患者较年轻(p < 0.001),男性较多(p = 0.003)。两组的所有PROMs均较基线有显著改善(p < 0.001),两组之间的最终PROMs无统计学差异。由于僵硬和疼痛,骨水泥组发生了一次翻修(2.0%);无骨水泥组(2.5%)需2次麻醉下操作。手术时间和住院时间均无差异。在短期随访中,无骨水泥和骨水泥机器人辅助tka在PROMs和生存率方面表现出同等的改善。在适当选择的患者中,特别是年轻人,当与机器人精度相结合时,无骨水泥植入物可能是一种可行的选择。需要长期数据来确认耐久性。
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引用次数: 0
Trabecular metal technology (TMT) cups in primary total hip arthroplasty: outcomes and survivorship of a large cohort 小梁金属技术(TMT)杯在初次全髋关节置换术中的应用:一个大队列的结果和生存率
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-24 DOI: 10.1007/s00402-025-06063-9
Alessandro El Motassime, Lorenzo Fulli, Rudy Sangaletti, Luca Andriollo, Francesco Benazzo, Stefano Marco Paolo Rossi
AbstractSection Introduction

Total hip arthroplasty (THA) is a widely performed procedure presenting substantial functional improvement in patients with hip joint pathology. Cementless acetabular components have well renowned popularity for their potential for long-term durability and bone preservation. Among these implants, trabecular metal technology (TMT), particularly using tantalum, has been introduced to enhance biological fixation and implant longevity.

AbstractSection Methods

This retrospective study analyzed 3464 primary THAs performed using tantalum TMT acetabular cups between 2012 and 2022 at a single high-volume arthroplasty center. Patients included were adults undergoing THA for osteoarthritis, hip dysplasia, post-traumatic arthritis, or avascular necrosis, with a minimum follow-up of 24 months. Clinical outcomes were evaluated using the Harris Hip Score (HHS), and implant survivorship was assessed via Kaplan–Meier analysis.

AbstractSection Results

The mean follow-up was 7.03 years (± 2.58). The mean HHS improved significantly from 46.7 (± 7.2) preoperatively to 91.07 (± 7.8) at final follow-up. The implant survivorship free from any reoperation was 97.78%, while survivorship free from aseptic loosening was 99.89%. Radiographically, mean cup inclination was 41.3° (± 5.9), with signs of potential aseptic loosening in only four cases (0.11%). Complications included 46 infections managed with DAIR/DAPRI and 30 implant-related revisions, primarily due to dislocation or mechanical failure.

AbstractSection Conclusion

Tantalum acetabular components demonstrate excellent mid-term clinical and radiographic performance in a broad patient population, suggesting their utility in both high-demand and compromised bone quality cases. Continued follow-up is necessary to confirm long-term implant survivorship.

摘要全髋关节置换术(THA)是一种广泛应用的手术,对髋关节病理患者的功能有实质性的改善。无骨水泥髋臼假体因其长期耐久性和骨保存的潜力而广受欢迎。在这些种植体中,小梁金属技术(TMT),特别是使用钽,已被引入以提高生物固定和种植体寿命。【摘要】本研究回顾性分析了2012年至2022年在单个大容量关节置换术中心使用钽TMT髋臼杯进行的3464例原发性髋关节置换术。纳入的患者是因骨关节炎、髋关节发育不良、创伤后关节炎或缺血性坏死而接受THA的成年人,随访时间至少为24个月。使用Harris髋关节评分(HHS)评估临床结果,通过Kaplan-Meier分析评估种植体存活率。【摘要】结果平均随访7.03年(±2.58年)。平均HHS由术前46.7(±7.2)分提高到最终随访时的91.07(±7.8)分。无再次手术的种植体成活率为97.78%,无无菌性松动的种植体成活率为99.89%。x线摄影显示,平均杯倾角为41.3°(±5.9),仅4例(0.11%)有潜在无菌性松动迹象。并发症包括46例DAIR/DAPRI感染和30例种植体相关修复,主要是由于脱位或机械故障。结论钽髋臼假体在广泛的患者群体中表现出优异的中期临床和影像学表现,表明其在高需求和骨质量受损病例中的应用。需要继续随访以确认种植体的长期存活。
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引用次数: 0
Biomechanical comparison of fixation techniques for associated both-column acetabular fractures requiring single (anterior or posterior) versus combined anterior–posterior approaches 单一(前路或后路)与前后路联合入路治疗合并髋臼双柱骨折的生物力学比较
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-24 DOI: 10.1007/s00402-025-06072-8
Dietmar Krappinger, Huy Le Quang, Werner Schmoelz, Peter Schwendinger, Andreas E. Ellmerer, Axel Gänsslen, Richard A. Lindtner

Introduction

Comparative data on fixation techniques for associated both-column (ABC) acetabular fractures are scarce. Compared with both column plating (AP + PP) via a combined anterior–posterior approach, single column plate plus other column lag screw fixation obviates the need for a second surgical approach. In this study, we (1) developed a clinically relevant ABC fracture model and (2) biomechanically compared the fixation strength of single column plate plus other column lag screw fixation and both column plating.

Materials and methods

An ABC fracture model was created using fourth-generation composite hemipelves. Three different ABC fracture fixation techniques were biomechanically compared: (1) anterior column plate plus posterior column screw fixation (AP + PCS), posterior column plate plus anterior column screw fixation (PP + ACS), and anterior column plate plus posterior column plate fixation (AP + PP). Both single-leg stance (SLS) and sit-to-stand (STS) loading protocols were applied (loads from 50 to 750 N, ramp: 100 N/s). Fracture gap motion (FGM) and relative interfragmentary rotation (RIFR) between the four main fracture fragments were analysed at 750 N using an optical 3D measurement system.

Results

Single column plate plus other column lag screw fixation techniques (AP + PCS and PP + ACS) provided comparable fixation strength to AP + PP, as evidenced by similar or even lower FGM and RIFR values. Moreover, no significant differences in FGM and RIFR were found between AP + PCS and PP + ACS. Compared to SLS loading, STS loading resulted in higher mean FGM and RIFR between the posterior iliac wing and the posterior column fragment across all fixation techniques.

Conclusions

In our ABC fracture model, both column plate fixation (AP + PP) via a combined approach did not demonstrate superior biomechanical stability compared with single column plate plus other column lag screw fixation. The latter, however, requires only one approach, thereby reducing surgical time and approach-related morbidity, and appears preferable if reduction of both columns is achievable through a single approach.

关于伴发双柱髋臼骨折固定技术的比较资料很少。与经前后联合入路的两柱钢板(AP + PP)相比,单柱钢板加其他柱拉力螺钉固定无需第二次手术入路。在本研究中,我们(1)建立了临床相关的ABC骨折模型;(2)从生物力学角度比较了单柱钢板加其他柱拉力螺钉固定和双柱钢板固定的固定强度。材料与方法采用第四代复合材料半棱形模型建立了san ABC断裂模型。对三种不同的ABC骨折固定技术进行生物力学比较:(1)前柱钢板加后柱螺钉固定(AP + PCS)、后柱钢板加前柱螺钉固定(PP + ACS)、前柱钢板加后柱钢板固定(AP + PP)。采用单腿站立(SLS)和坐立(STS)加载方案(负载从50到750 N,斜坡:100 N/s)。使用光学三维测量系统分析了750 N下四个主要断裂碎片之间的断裂间隙运动(FGM)和相对碎片间旋转(RIFR)。结果单柱钢板加其他柱拉力螺钉固定技术(AP + PCS和PP + ACS)的固定强度与AP + PP相当,FGM和RIFR值相似甚至更低。AP + PCS与PP + ACS在FGM和RIFR方面无显著差异。与SLS载荷相比,STS载荷在所有固定技术中导致髂后翼和后柱碎片之间的平均FGM和RIFR更高。结论在我们的ABC骨折模型中,两种柱钢板联合固定(AP + PP)与单柱钢板加其他柱拉力螺钉固定相比没有更好的生物力学稳定性。然而,后者只需要一个入路,从而减少手术时间和入路相关的发病率,如果通过单一入路可以实现双柱的复位,则更可取。
{"title":"Biomechanical comparison of fixation techniques for associated both-column acetabular fractures requiring single (anterior or posterior) versus combined anterior–posterior approaches","authors":"Dietmar Krappinger,&nbsp;Huy Le Quang,&nbsp;Werner Schmoelz,&nbsp;Peter Schwendinger,&nbsp;Andreas E. Ellmerer,&nbsp;Axel Gänsslen,&nbsp;Richard A. Lindtner","doi":"10.1007/s00402-025-06072-8","DOIUrl":"10.1007/s00402-025-06072-8","url":null,"abstract":"<div><h3>Introduction</h3><p>Comparative data on fixation techniques for associated both-column (ABC) acetabular fractures are scarce. Compared with both column plating (AP + PP) via a combined anterior–posterior approach, single column plate plus other column lag screw fixation obviates the need for a second surgical approach. In this study, we (1) developed a clinically relevant ABC fracture model and (2) biomechanically compared the fixation strength of single column plate plus other column lag screw fixation and both column plating.</p><h3>Materials and methods</h3><p>An ABC fracture model was created using fourth-generation composite hemipelves. Three different ABC fracture fixation techniques were biomechanically compared: (1) anterior column plate plus posterior column screw fixation (AP + PCS), posterior column plate plus anterior column screw fixation (PP + ACS), and anterior column plate plus posterior column plate fixation (AP + PP). Both single-leg stance (SLS) and sit-to-stand (STS) loading protocols were applied (loads from 50 to 750 N, ramp: 100 N/s). Fracture gap motion (FGM) and relative interfragmentary rotation (RIFR) between the four main fracture fragments were analysed at 750 N using an optical 3D measurement system.</p><h3>Results</h3><p>Single column plate plus other column lag screw fixation techniques (AP + PCS and PP + ACS) provided comparable fixation strength to AP + PP, as evidenced by similar or even lower FGM and RIFR values. Moreover, no significant differences in FGM and RIFR were found between AP + PCS and PP + ACS. Compared to SLS loading, STS loading resulted in higher mean FGM and RIFR between the posterior iliac wing and the posterior column fragment across all fixation techniques.</p><h3>Conclusions</h3><p>In our ABC fracture model, both column plate fixation (AP + PP) via a combined approach did not demonstrate superior biomechanical stability compared with single column plate plus other column lag screw fixation. The latter, however, requires only one approach, thereby reducing surgical time and approach-related morbidity, and appears preferable if reduction of both columns is achievable through a single approach.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06072-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145352887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and treatment of surgical infections after distal radius fractures: a systematic review 桡骨远端骨折后手术感染的流行病学和治疗:系统综述。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-23 DOI: 10.1007/s00402-025-06061-x
Andrea Cruciani, Cristina Giuli, Giulia Di Pietro, Luigi Cianni, Camillo Fulchignoni, Pierluigi Del Vecchio, Giulio Maccauro, Raffaele Vitiello

Introduction

Distal radius fractures (DRFs) are among the most frequent injuries treated by orthopaedic surgeons. Although postoperative infection is uncommon, it represents a clinically relevant complication that may affect outcomes. This systematic review aimed to evaluate the incidence, subtypes, and treatment of infections following surgical management of DRFs.

Materials and methods

A systematic search of MEDLINE/PubMed and Cochrane Library was performed from inception to June 2024, following PRISMA guidelines. English-language longitudinal studies (prospective or retrospective) reporting infection after DRF surgery were included. Case reports, meta-analyses, animal studies, and articles without relevant outcomes were excluded. Extracted data included infection incidence, classification, microbiological findings, and reported management.

Results

Fifty-five studies met inclusion criteria, encompassing 6499 patients and 6451 procedures. A total of 341 infections were reported (5.3%). Superficial surgical site infections accounted for 22.6% of cases, deep infections for 12.0%, and pin-tract infections for 61.0%. Infection rates differed by fixation method: approximately 2.0% for open reduction and internal fixation, 12.0% for Kirschner-wire fixation, and 13.9% for external fixation. Microbiological confirmation was reported only in a minority of studies; when available, Staphylococcus aureus was the most frequently isolated organism. Management strategies ranged from oral antibiotics and local wound care for superficial infections to intravenous antibiotics with debridement and hardware removal for severe cases.

Conclusions

Infections following DRF surgery are relatively rare but vary across fixation techniques, with pin-tract infections predominating in percutaneous and external constructs. The heterogeneity of infection definitions and the scarcity of microbiological reporting limit comparability between studies. Standardized SSI/FRI classification and more consistent documentation are needed to improve evidence-based prevention and treatment strategies.

桡骨远端骨折(DRFs)是骨科医生治疗的最常见的损伤之一。虽然术后感染并不常见,但它是一种可能影响预后的临床相关并发症。本系统综述旨在评估DRFs手术后感染的发生率、亚型和治疗。材料和方法:根据PRISMA指南,从成立到2024年6月对MEDLINE/PubMed和Cochrane图书馆进行系统检索。纳入了报告DRF手术后感染的英语纵向研究(前瞻性或回顾性)。排除病例报告、荟萃分析、动物研究和没有相关结果的文章。提取的数据包括感染发生率、分类、微生物学结果和报告的管理。结果:55项研究符合纳入标准,包括6499名患者和6451项手术。共报告感染341例(5.3%)。手术部位浅表感染占22.6%,深部感染占12.0%,针道感染占61.0%。不同固定方式的感染率不同:切开复位内固定约为2.0%,克氏针固定约为12.0%,外固定约为13.9%。仅在少数研究中报道了微生物证实;在可用的情况下,金黄色葡萄球菌是最常见的分离生物。管理策略包括对浅表感染的口服抗生素和局部伤口护理,对严重病例的静脉注射抗生素并清创和取出硬体。结论:DRF手术后的感染相对罕见,但不同的固定技术不同,针道感染主要是经皮和外固定装置。感染定义的异质性和微生物报告的稀缺性限制了研究之间的可比性。需要标准化的SSI/FRI分类和更一致的文献来改进循证预防和治疗策略。
{"title":"Epidemiology and treatment of surgical infections after distal radius fractures: a systematic review","authors":"Andrea Cruciani,&nbsp;Cristina Giuli,&nbsp;Giulia Di Pietro,&nbsp;Luigi Cianni,&nbsp;Camillo Fulchignoni,&nbsp;Pierluigi Del Vecchio,&nbsp;Giulio Maccauro,&nbsp;Raffaele Vitiello","doi":"10.1007/s00402-025-06061-x","DOIUrl":"10.1007/s00402-025-06061-x","url":null,"abstract":"<div><h3>Introduction</h3><p>Distal radius fractures (DRFs) are among the most frequent injuries treated by orthopaedic surgeons. Although postoperative infection is uncommon, it represents a clinically relevant complication that may affect outcomes. This systematic review aimed to evaluate the incidence, subtypes, and treatment of infections following surgical management of DRFs.</p><h3>Materials and methods</h3><p>A systematic search of MEDLINE/PubMed and Cochrane Library was performed from inception to June 2024, following PRISMA guidelines. English-language longitudinal studies (prospective or retrospective) reporting infection after DRF surgery were included. Case reports, meta-analyses, animal studies, and articles without relevant outcomes were excluded. Extracted data included infection incidence, classification, microbiological findings, and reported management.</p><h3>Results</h3><p>Fifty-five studies met inclusion criteria, encompassing 6499 patients and 6451 procedures. A total of 341 infections were reported (5.3%). Superficial surgical site infections accounted for 22.6% of cases, deep infections for 12.0%, and pin-tract infections for 61.0%. Infection rates differed by fixation method: approximately 2.0% for open reduction and internal fixation, 12.0% for Kirschner-wire fixation, and 13.9% for external fixation. Microbiological confirmation was reported only in a minority of studies; when available, <i>Staphylococcus aureus</i> was the most frequently isolated organism. Management strategies ranged from oral antibiotics and local wound care for superficial infections to intravenous antibiotics with debridement and hardware removal for severe cases.</p><h3>Conclusions</h3><p>Infections following DRF surgery are relatively rare but vary across fixation techniques, with pin-tract infections predominating in percutaneous and external constructs. The heterogeneity of infection definitions and the scarcity of microbiological reporting limit comparability between studies. Standardized SSI/FRI classification and more consistent documentation are needed to improve evidence-based prevention and treatment strategies.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06061-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total joint arthroplasty patients who experience the minimal clinically important difference for worsening (MCID-W) have higher revision rates at 1, 3, and 5 years postoperatively: 经历最小临床重要恶化差异(MCID-W)的全关节置换术患者在术后1年、3年和5年的翻修率更高。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-21 DOI: 10.1007/s00402-025-06068-4
Perry L. Lim, Nicholas Sauder, Shian L. Peterson, Christopher M. Melnic, Hany S. Bedair

Introduction

The Minimal Clinically Important Difference (MCID) is critical in assessing patient-reported outcomes following total joint arthroplasty (TJA). Although many studies consider the MCID for Improvement (MCID-I), thresholds have also been defined for the MCID for Worsening (MCID-W). However, the potential impact of the MCID-W on surgical outcomes in TJA is under-investigated. This study investigated the association between the MCID-W and revision rate.

Materials and methods

This retrospective study was performed using 2787 primary TJAs—1563 total knee arthroplasties (TKAs) and 1224 total hip arthroplasties (THAs)—with minimum five-year follow-up. Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) scores were collected preoperatively and at one-year postoperatively. Patients were classified based on experiencing MCID-I, MCID-W, or “no change” after TJA (scores between MCID-I and MCID-W). MCID-W and MCID-I values were determined by a distribution-based method. Revision-free survival was compared at 1 year, 3 years, and 5 years postoperatively.

Results

The overall revision rate for the entire TJA cohort was 1.1% at 1 year, 1.8% at 3 years, and 2.2% at 5 years postoperatively. TJA patients who experienced MCID-W had a higher revision rate than MCID-I patients at 1 year (3.6 versus 0.8%, P < 0.001), 3 years (5.3 versus 1.1%, P < 0.001), and 5 years postoperatively (5.7 versus 1.5%, P < 0.001). Similarly, stratifying into TKAs and THAs revealed an association between MCID-W and higher revision rates. Revision-free survival curves for MCID-W patients revealed lower survival at 1 year (P < 0.001), 3 years (P < 0.001), and 5 years (P < 0.001).

Conclusions

Patients experiencing the MCID-W are more likely to undergo revision surgery at 1, 3, and 5 years following both THA and TKA procedures. The MCID-W may be a useful tool to help identify postoperative THA and TKA patients at highest risk for revision surgery. Future studies utilizing MCID-W as a predictive tool are needed to determine its effectiveness in optimizing TJA patient outcomes.

最小临床重要差异(MCID)在评估全关节置换术(TJA)后患者报告的结果中至关重要。尽管许多研究考虑了改善型MCID (MCID- i),但也定义了恶化型MCID (MCID- w)的阈值。然而,MCID-W对TJA手术结果的潜在影响尚未得到充分研究。本研究探讨了MCID-W与复习率之间的关系。材料和方法:本回顾性研究包括2787例原发性TJAs-1563全膝关节置换术(tka)和1224例全髋关节置换术(tha),随访时间至少为5年。术前和术后1年收集患者报告结果测量信息系统生理功能短表10a (PROMIS PF-10a)评分。患者根据TJA后mcid - 1、MCID-W或“无变化”(评分介于mcid - 1和MCID-W之间)进行分类。MCID-W和MCID-I值采用基于分布的方法确定。在术后1年、3年和5年比较无修复生存期。结果:整个TJA队列的总体修订率为术后1年1.1%,3年1.8%,5年2.2%。经历过MCID-W的TJA患者在1年内的翻修率高于mcid - 1患者(3.6% vs 0.8%, P)。结论:经历过MCID-W的患者更有可能在THA和TKA手术后的1,3和5年接受翻修手术。MCID-W可能是一个有用的工具,可以帮助识别THA和TKA术后翻修手术风险最高的患者。未来的研究需要利用MCID-W作为预测工具来确定其在优化TJA患者预后方面的有效性。
{"title":"Total joint arthroplasty patients who experience the minimal clinically important difference for worsening (MCID-W) have higher revision rates at 1, 3, and 5 years postoperatively:","authors":"Perry L. Lim,&nbsp;Nicholas Sauder,&nbsp;Shian L. Peterson,&nbsp;Christopher M. Melnic,&nbsp;Hany S. Bedair","doi":"10.1007/s00402-025-06068-4","DOIUrl":"10.1007/s00402-025-06068-4","url":null,"abstract":"<div><h3>Introduction</h3><p>The Minimal Clinically Important Difference (MCID) is critical in assessing patient-reported outcomes following total joint arthroplasty (TJA). Although many studies consider the MCID for Improvement (MCID-I), thresholds have also been defined for the MCID for Worsening (MCID-W). However, the potential impact of the MCID-W on surgical outcomes in TJA is under-investigated. This study investigated the association between the MCID-W and revision rate.</p><h3>Materials and methods</h3><p>This retrospective study was performed using 2787 primary TJAs—1563 total knee arthroplasties (TKAs) and 1224 total hip arthroplasties (THAs)—with minimum five-year follow-up. Patient-Reported Outcomes Measurement Information System Physical Function Short Form 10a (PROMIS PF-10a) scores were collected preoperatively and at one-year postoperatively. Patients were classified based on experiencing MCID-I, MCID-W, or “no change” after TJA (scores between MCID-I and MCID-W). MCID-W and MCID-I values were determined by a distribution-based method. Revision-free survival was compared at 1 year, 3 years, and 5 years postoperatively.</p><h3>Results</h3><p>The overall revision rate for the entire TJA cohort was 1.1% at 1 year, 1.8% at 3 years, and 2.2% at 5 years postoperatively. TJA patients who experienced MCID-W had a higher revision rate than MCID-I patients at 1 year (3.6 versus 0.8%, <i>P</i> &lt; 0.001), 3 years (5.3 versus 1.1%, <i>P</i> &lt; 0.001), and 5 years postoperatively (5.7 versus 1.5%, <i>P</i> &lt; 0.001). Similarly, stratifying into TKAs and THAs revealed an association between MCID-W and higher revision rates. Revision-free survival curves for MCID-W patients revealed lower survival at 1 year (<i>P</i> &lt; 0.001), 3 years (<i>P</i> &lt; 0.001), and 5 years (<i>P</i> &lt; 0.001).</p><h3>Conclusions</h3><p>Patients experiencing the MCID-W are more likely to undergo revision surgery at 1, 3, and 5 years following both THA and TKA procedures. The MCID-W may be a useful tool to help identify postoperative THA and TKA patients at highest risk for revision surgery. Future studies utilizing MCID-W as a predictive tool are needed to determine its effectiveness in optimizing TJA patient outcomes.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reverse arthroplasty compared to hemiarthroplasty and open reduction and internal fixation for displaced proximal humerus fracture in patients above 60: a Bayesian network meta-analysis 60岁以上患者肱骨近端移位骨折逆行关节置换术与半关节置换术、切开复位内固定的比较:一项贝叶斯网络meta分析
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-18 DOI: 10.1007/s00402-025-06067-5
Filippo Migliorini, Giuliano Sammaria, Luise Schäfer, Michael Memminger, Francesco Simeone, Nicola Maffulli
AbstractSection Introduction

The present Bayesian network meta-analysis compared reverse total shoulder arthroplasty (rTSA) to hemiarthroplasty (HA) and open reduction and internal fixation (ORIF) for displaced proximal humeral fractures (PHF) in patients above 60.

AbstractSection Methods

This study was conducted according to the PRISMA extension statement for reporting systematic reviews incorporating network meta-analyses of healthcare interventions. In December 2024, PubMed, Web of Science, and Embase databases were accessed. No time constraint was set for the search. All clinical studies were accessed comparing rTSA, ORIF and HA for displaced PHF in patients older than 60. Only studies which compared at least two of the interventions of interest were eligible when they reported a minimum of 12 months of follow-up. Two-, three-, and four-part displaced fractures and fractures with a head-splitting component were considered.

AbstractSection Results

Data from 878 procedures were collected. 72% (631 of 878 patients) were women. The mean length of the follow-up was 33.8 ± 14.8 months. The mean age of the patients was 73.4 ± 4.6 years. Between groups, comparability was found in the mean age, the ratio of men to women, the length of the follow-up, and the time elapsed from injury to the procedure. The rTSA demonstrated the lowest rate of complications, followed by HA and ORIF. The rTSA demonstrated the lowest rate of revision, followed by HA and ORIF. Given the limited and heterogeneous data, only complications and revision rates were analysed in the network meta-analysis; functional outcomes were discussed narratively.

AbstractSection Conclusion

In patients above 60 with displaced PHF, rTSA was associated with a lower complication and revision rate than ORIF and HA.

AbstractSection Level of evidence

Level IV, systematic review and meta-analysis.

本贝叶斯网络meta分析比较了逆行全肩关节置换术(rTSA)与半关节置换术(HA)和切开复位内固定(ORIF)治疗60岁以上肱骨近端移位骨折(PHF)的疗效。摘要章节方法本研究是根据PRISMA报告系统评价扩展声明进行的,纳入了医疗保健干预措施的网络meta分析。2024年12月,PubMed、Web of Science和Embase数据库被访问。没有为搜索设置时间限制。所有的临床研究都比较了rTSA、ORIF和HA治疗60岁以上患者的移位性PHF。只有比较了至少两种感兴趣的干预措施的研究在报告至少12个月的随访时才符合条件。考虑了二、三、四部分移位骨折和有劈头成分的骨折。结果共收集878例手术资料。72%(878例患者中的631例)为女性。平均随访时间为33.8±14.8个月。患者平均年龄73.4±4.6岁。在两组之间,在平均年龄、男女比例、随访时间和从受伤到手术的时间上发现了可比性。rTSA的并发症发生率最低,HA和ORIF次之。rTSA的修复率最低,HA和ORIF次之。由于数据有限且异构,网络荟萃分析仅分析并发症和修改率;叙述功能结果。结论在60岁以上移位性PHF患者中,rTSA的并发症和翻修率低于ORIF和HA。【摘要】第四节证据水平、系统评价和荟萃分析。
{"title":"Reverse arthroplasty compared to hemiarthroplasty and open reduction and internal fixation for displaced proximal humerus fracture in patients above 60: a Bayesian network meta-analysis","authors":"Filippo Migliorini,&nbsp;Giuliano Sammaria,&nbsp;Luise Schäfer,&nbsp;Michael Memminger,&nbsp;Francesco Simeone,&nbsp;Nicola Maffulli","doi":"10.1007/s00402-025-06067-5","DOIUrl":"10.1007/s00402-025-06067-5","url":null,"abstract":"<div>\u0000 \u0000 <span>AbstractSection</span>\u0000 Introduction\u0000 <p>The present Bayesian network meta-analysis compared reverse total shoulder arthroplasty (rTSA) to hemiarthroplasty (HA) and open reduction and internal fixation (ORIF) for displaced proximal humeral fractures (PHF) in patients above 60.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Methods\u0000 <p>This study was conducted according to the PRISMA extension statement for reporting systematic reviews incorporating network meta-analyses of healthcare interventions. In December 2024, PubMed, Web of Science, and Embase databases were accessed. No time constraint was set for the search. All clinical studies were accessed comparing rTSA, ORIF and HA for displaced PHF in patients older than 60. Only studies which compared at least two of the interventions of interest were eligible when they reported a minimum of 12 months of follow-up. Two-, three-, and four-part displaced fractures and fractures with a head-splitting component were considered.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Results\u0000 <p>Data from 878 procedures were collected. 72% (631 of 878 patients) were women. The mean length of the follow-up was 33.8 ± 14.8 months. The mean age of the patients was 73.4 ± 4.6 years. Between groups, comparability was found in the mean age, the ratio of men to women, the length of the follow-up, and the time elapsed from injury to the procedure. The rTSA demonstrated the lowest rate of complications, followed by HA and ORIF. The rTSA demonstrated the lowest rate of revision, followed by HA and ORIF. Given the limited and heterogeneous data, only complications and revision rates were analysed in the network meta-analysis; functional outcomes were discussed narratively.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Conclusion\u0000 <p>In patients above 60 with displaced PHF, rTSA was associated with a lower complication and revision rate than ORIF and HA.</p>\u0000 \u0000 <span>AbstractSection</span>\u0000 Level of evidence\u0000 <p>Level IV, systematic review and meta-analysis.</p>\u0000 \u0000 </div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06067-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quadrilateral surface plating combined with anti-protrusio cage for pelvic discontinuity—a preliminary clinical comparison of a novel technique 四边形表面镀联合防突笼治疗骨盆不连续——一种新技术的初步临床比较。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-17 DOI: 10.1007/s00402-025-06093-3
Mehmet Suleyman Abul, Muzaffer Agir, Omer Faruk Sevim, Engin Eceviz, İbrahim Tuncay

Background

Pelvic discontinuity is a rare but challenging condition in revision hip arthroplasty. Traditional reconstruction with anti-protrusio cages often lacks anterior support, providing no resistance against medial migration or implant protrusion, thereby potentially compromising long-term stability and implant longevity.

Methods

This retrospective study included 13 patients with intraoperatively confirmed pelvic discontinuity who underwent revision total hip arthroplasty between 2014 and 2023. Patients were divided into two groups: Group 1 (n = 8) received anti-protrusio cage reconstruction alone, while Group 2 (n = 5) underwent additional anterior quadrilateral surface plating prior to cage implantation. Clinical and radiological outcomes were assessed with a minimum follow-up of 2 years (mean: 6.3 years), including complications, loosening, and reoperation.

Results

Thirteen patients (mean age: 73.3 years) with intraoperatively confirmed pelvic discontinuity were included.Complication and reoperation rates were significantly higher in Group 1 (75%) compared to Group 2 (20%) (p < 0.001). Kaplan–Meier analysis demonstrated superior complication-free survival in Group 2 (80% at 11 years) versus Group 1 (37.5% at 11 years). Periprosthetic fracture rates did not differ significantly (p = 0.21).

Conclusion

Preliminary results suggest that the addition of quadrilateral surface plating may enhance construct stability and reduce complications. Further studies with larger cohorts and biomechanical validation are warranted.

背景:骨盆不连续是髋关节翻修成形术中一种罕见但具有挑战性的疾病。传统的抗突出笼重建通常缺乏前路支持,无法抵抗内侧移动或种植体突出,因此可能影响种植体的长期稳定性和使用寿命。方法:本回顾性研究纳入了2014年至2023年间13例术中确诊盆腔不连续并行翻修全髋关节置换术的患者。患者分为两组:组1 (n = 8)单独行抗突出笼重建,组2 (n = 5)在植入笼前行前四边形表面电镀。临床和放射学结果通过至少2年的随访(平均6.3年)进行评估,包括并发症、松动和再手术。结果:13例患者(平均年龄:73.3岁)术中证实盆腔不连续。组1的并发症和再手术率(75%)明显高于组2 (20%)(p)。结论:初步结果表明,加入四边形表面电镀可以提高假体的稳定性,减少并发症。进一步的研究更大的队列和生物力学验证是必要的。
{"title":"Quadrilateral surface plating combined with anti-protrusio cage for pelvic discontinuity—a preliminary clinical comparison of a novel technique","authors":"Mehmet Suleyman Abul,&nbsp;Muzaffer Agir,&nbsp;Omer Faruk Sevim,&nbsp;Engin Eceviz,&nbsp;İbrahim Tuncay","doi":"10.1007/s00402-025-06093-3","DOIUrl":"10.1007/s00402-025-06093-3","url":null,"abstract":"<div><h3>Background</h3><p>Pelvic discontinuity is a rare but challenging condition in revision hip arthroplasty. Traditional reconstruction with anti-protrusio cages often lacks anterior support, providing no resistance against medial migration or implant protrusion, thereby potentially compromising long-term stability and implant longevity.</p><h3>Methods</h3><p>This retrospective study included 13 patients with intraoperatively confirmed pelvic discontinuity who underwent revision total hip arthroplasty between 2014 and 2023. Patients were divided into two groups: Group 1 (<i>n</i> = 8) received anti-protrusio cage reconstruction alone, while Group 2 (<i>n</i> = 5) underwent additional anterior quadrilateral surface plating prior to cage implantation. Clinical and radiological outcomes were assessed with a minimum follow-up of 2 years (mean: 6.3 years), including complications, loosening, and reoperation.</p><h3>Results</h3><p>Thirteen patients (mean age: 73.3 years) with intraoperatively confirmed pelvic discontinuity were included.Complication and reoperation rates were significantly higher in Group 1 (75%) compared to Group 2 (20%) (<i>p</i> &lt; 0.001). Kaplan–Meier analysis demonstrated superior complication-free survival in Group 2 (80% at 11 years) versus Group 1 (37.5% at 11 years). Periprosthetic fracture rates did not differ significantly (<i>p</i> = 0.21).</p><h3>Conclusion</h3><p>Preliminary results suggest that the addition of quadrilateral surface plating may enhance construct stability and reduce complications. Further studies with larger cohorts and biomechanical validation are warranted.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association betweensubchondral bone sclerosis and pain in varus ankle osteoarthritis: a CT-based analysis using patient-reported outcomes 膝关节内翻性骨关节炎软骨下骨硬化与疼痛之间的关系:基于ct的患者报告结果分析
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-17 DOI: 10.1007/s00402-025-06096-0
Dan Moriwaki, Tomoyuki Nakasa, Yasunari Ikuta, Saori Ishibashi, Satoru Sakurai, Taro Chujo, Nobuo Adachi

Purpose

Although severe pain caused by progressive ankle osteoarthritis (OA) impairs patients’ quality of life, factors associated with severe pain in ankle OA are unknown. This study aimed to analyze the characteristics of pain and the association between pain, radiographic alignment, and computed tomography (CT) and magnetic resonance imaging (MRI) findings in patients with varus ankle OA.

Methods

Seventy-five ankles from 73 patients with varus ankle OA who underwent surgery were retrospectively reviewed. Pain was evaluated using the self-administered foot evaluation questionnaire (SAFE-Q). Ankle alignment was assessed by radiography. Subchondral bone sclerosis was assessed by CT-derived Hounsfield unit (HU) ratio, and synovitis and bone marrow edema (BME) were assessed by MRI. The relationship between pain and imaging findings was analyzed.

Results

Pain and pain-related scores in the SAFE-Q significantly correlated with the Takakura-Tanaka classification stage (r = − 0.529), osteophyte score (r = − 0.460), HU ratios (r = − 0.729), synovial thickness score (r = − 0.387), and BME area (r = − 0.475). Multivariate analysis revealed that high HU ratio, progressed OA stage, and thick synovium were significantly associated with severe pain. Notably, HU ratios showed moderate to strong correlations with pain, regardless of radiographic severity, even in the regions where joint space was radiographically preserved.

Conclusions

Subchondral bone sclerosis, OA severity, and synovitis are significantly correlated with pain in patients with varus ankle OA. The novel finding is that HU ratios of subchondral bone correlate with pain irrespective of radiographic stage, suggesting that severe pain reflects hidden mechanical stress and cartilage degeneration associated with subchondral sclerosis. Varus ankle OA with severe pain should be managed early and appropriately, regardless of radiographic severity.

Level of evidence

III.

目的:虽然进行性踝关节骨关节炎(OA)引起的剧烈疼痛会损害患者的生活质量,但与踝关节骨关节炎(OA)剧烈疼痛相关的因素尚不清楚。本研究旨在分析踝关节内翻性骨关节炎患者的疼痛特征,以及疼痛、x线线、计算机断层扫描(CT)和磁共振成像(MRI)结果之间的关系。方法:回顾性分析73例踝关节内翻骨性关节炎患者的75个踝关节。采用自我管理足部评估问卷(SAFE-Q)评估疼痛。通过x线摄影评估踝关节对齐。采用ct Hounsfield单位(HU)比评估软骨下骨硬化,MRI评估滑膜炎和骨髓水肿(BME)。分析疼痛与影像学表现的关系。结果:SAFE-Q疼痛及疼痛相关评分与Takakura-Tanaka分级分期(r = - 0.529)、骨癣评分(r = - 0.460)、HU比值(r = - 0.729)、滑膜厚度评分(r = - 0.387)、BME面积(r = - 0.475)显著相关。多因素分析显示,高HU比、OA分期进展和滑膜厚与严重疼痛显著相关。值得注意的是,无论放射学的严重程度如何,即使在关节间隙被放射学保留的区域,HU比率也显示出中度到强相关性。结论:软骨下骨硬化、骨性关节炎严重程度和滑膜炎与踝关节内翻骨性关节炎患者的疼痛显著相关。新的发现是,软骨下骨的HU比与疼痛无关,与x线分期有关,这表明严重的疼痛反映了与软骨下硬化相关的隐藏机械应力和软骨退变。踝关节内翻性骨关节炎伴剧烈疼痛应及早适当处理,无论放射学的严重程度如何。证据水平:III。
{"title":"Association betweensubchondral bone sclerosis and pain in varus ankle osteoarthritis: a CT-based analysis using patient-reported outcomes","authors":"Dan Moriwaki,&nbsp;Tomoyuki Nakasa,&nbsp;Yasunari Ikuta,&nbsp;Saori Ishibashi,&nbsp;Satoru Sakurai,&nbsp;Taro Chujo,&nbsp;Nobuo Adachi","doi":"10.1007/s00402-025-06096-0","DOIUrl":"10.1007/s00402-025-06096-0","url":null,"abstract":"<div><h3>Purpose</h3><p>Although severe pain caused by progressive ankle osteoarthritis (OA) impairs patients’ quality of life, factors associated with severe pain in ankle OA are unknown. This study aimed to analyze the characteristics of pain and the association between pain, radiographic alignment, and computed tomography (CT) and magnetic resonance imaging (MRI) findings in patients with varus ankle OA.</p><h3>Methods</h3><p>Seventy-five ankles from 73 patients with varus ankle OA who underwent surgery were retrospectively reviewed. Pain was evaluated using the self-administered foot evaluation questionnaire (SAFE-Q). Ankle alignment was assessed by radiography. Subchondral bone sclerosis was assessed by CT-derived Hounsfield unit (HU) ratio, and synovitis and bone marrow edema (BME) were assessed by MRI. The relationship between pain and imaging findings was analyzed.</p><h3>Results</h3><p>Pain and pain-related scores in the SAFE-Q significantly correlated with the Takakura-Tanaka classification stage (<i>r</i> = − 0.529), osteophyte score (<i>r</i> = − 0.460), HU ratios (<i>r</i> = − 0.729), synovial thickness score (<i>r</i> = − 0.387), and BME area (<i>r</i> = − 0.475). Multivariate analysis revealed that high HU ratio, progressed OA stage, and thick synovium were significantly associated with severe pain. Notably, HU ratios showed moderate to strong correlations with pain, regardless of radiographic severity, even in the regions where joint space was radiographically preserved.</p><h3>Conclusions</h3><p>Subchondral bone sclerosis, OA severity, and synovitis are significantly correlated with pain in patients with varus ankle OA. The novel finding is that HU ratios of subchondral bone correlate with pain irrespective of radiographic stage, suggesting that severe pain reflects hidden mechanical stress and cartilage degeneration associated with subchondral sclerosis. Varus ankle OA with severe pain should be managed early and appropriately, regardless of radiographic severity.</p><h3>Level of evidence</h3><p>III.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00402-025-06096-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bipolar disorder medications are associated with increased odds of fracture nonunion 双相情感障碍药物与骨折不愈合的几率增加有关。
IF 2.1 3区 医学 Q2 ORTHOPEDICS Pub Date : 2025-10-17 DOI: 10.1007/s00402-025-06101-6
Samuel S. Gay, Adam Nguyen, Jared D. Wainwright, Joseph C. Wenke

Purpose

The purpose of this study was to assess the odds of nonunion for open and closed fractures in patients with bipolar disorder (BD) and characterize any confounding effect of medication prescription.

Materials and methods

This was a retrospective cohort study with data sourced from the TriNetX Research database. Our query was for patients that are ≥ 18 years old with extremity long bone fractures with and without prior BD diagnosis. A 1:1 propensity score matching method, matching for age; sex; nicotine use; long-term NSAID use; long-term opioid use; and prior diagnoses of obesity, osteoporosis, and the Charlson comorbidities, was used to create reference groups. The primary outcome was fracture nonunion. Odds of fracture nonunion of the observed groups were compared to the control groups using an odds ratio (OR) with 95% confidence interval (CI).

Results

A total of 1,824,610 patients with long bone fractures were analyzed, with 2.8% having BD. The nonunion rate was higher in patients with BD (3.9%) than those without BD (3.2%, P < .001). The highest nonunion rates were observed in open fractures at 5.1–16.2%, with no significant difference between patients with and without BD (OR 1.04, 95% CI 0.89–1.22). Closed fractures had nonunion rates of 1.6–5.4%, with BD patients showing 1.30 times higher odds (95% CI 1.21–1.41). In BD patients, having a medication prescription for treatment of BD increased the odds of nonunion in closed fractures by 1.68 times (95% CI 1.50–1.88) when compared to those without medication prescription. When patients prescribed medications were removed, BD patients no longer had significantly different odds of nonunion in closed fractures (OR 1.07, 95% CI 0.95–1.21).

Conclusions

Pharmacological prescriptions for BD, but not BD itself, were associated with significantly increased odds of nonunion in closed fractures, while open fractures were unaffected. Orthopaedic surgeons should consider these increased odds when treating these patients and tailor fracture treatment strategies accordingly.

目的:本研究的目的是评估双相情感障碍(BD)患者开放性和闭合性骨折不愈合的几率,并描述药物处方的任何混杂效应。材料和方法:这是一项回顾性队列研究,数据来自TriNetX研究数据库。我们的调查对象是年龄≥18岁的四肢长骨骨折患者,既往有或没有BD诊断。采用1:1倾向评分匹配法,匹配年龄;性;尼古丁使用;长期使用非甾体抗炎药;长期使用阿片类药物;以及肥胖、骨质疏松和查尔森合并症的既往诊断,被用来创建参照组。主要结局为骨折不愈合。采用95%可信区间(CI)的比值比(OR)比较观察组与对照组骨折不愈合的几率。结果:共分析了1,824,610例长骨骨折患者,其中2.8%患有BD。BD患者的不愈合率(3.9%)高于非BD患者(3.2%),P结论:BD的药物处方与闭合性骨折不愈合的发生率显著增加相关,而不是BD本身,而开放骨折不受影响。骨科医生在治疗这些患者时应考虑到这些增加的可能性,并相应地调整骨折治疗策略。
{"title":"Bipolar disorder medications are associated with increased odds of fracture nonunion","authors":"Samuel S. Gay,&nbsp;Adam Nguyen,&nbsp;Jared D. Wainwright,&nbsp;Joseph C. Wenke","doi":"10.1007/s00402-025-06101-6","DOIUrl":"10.1007/s00402-025-06101-6","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of this study was to assess the odds of nonunion for open and closed fractures in patients with bipolar disorder (BD) and characterize any confounding effect of medication prescription.</p><h3>Materials and methods</h3><p>This was a retrospective cohort study with data sourced from the TriNetX Research database. Our query was for patients that are ≥ 18 years old with extremity long bone fractures with and without prior BD diagnosis. A 1:1 propensity score matching method, matching for age; sex; nicotine use; long-term NSAID use; long-term opioid use; and prior diagnoses of obesity, osteoporosis, and the Charlson comorbidities, was used to create reference groups. The primary outcome was fracture nonunion. Odds of fracture nonunion of the observed groups were compared to the control groups using an odds ratio (OR) with 95% confidence interval (CI).</p><h3>Results</h3><p>A total of 1,824,610 patients with long bone fractures were analyzed, with 2.8% having BD. The nonunion rate was higher in patients with BD (3.9%) than those without BD (3.2%, <i>P</i> &lt; .001). The highest nonunion rates were observed in open fractures at 5.1–16.2%, with no significant difference between patients with and without BD (OR 1.04, 95% CI 0.89–1.22). Closed fractures had nonunion rates of 1.6–5.4%, with BD patients showing 1.30 times higher odds (95% CI 1.21–1.41). In BD patients, having a medication prescription for treatment of BD increased the odds of nonunion in closed fractures by 1.68 times (95% CI 1.50–1.88) when compared to those without medication prescription. When patients prescribed medications were removed, BD patients no longer had significantly different odds of nonunion in closed fractures (OR 1.07, 95% CI 0.95–1.21).</p><h3>Conclusions</h3><p>Pharmacological prescriptions for BD, but not BD itself, were associated with significantly increased odds of nonunion in closed fractures, while open fractures were unaffected. Orthopaedic surgeons should consider these increased odds when treating these patients and tailor fracture treatment strategies accordingly.</p></div>","PeriodicalId":8326,"journal":{"name":"Archives of Orthopaedic and Trauma Surgery","volume":"145 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Archives of Orthopaedic and Trauma Surgery
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