Journal of Materials Chemistry B最新文献

Heterogeneous piezo-self-Fenton (EPSF), an integration of piezocatalysis and heterogeneous Fenton reactions, forms the foundation for efficient redox interfacial reactions in complex environments. The significant generation of reactive oxygen species (ROS) during the catalytic process and the mechanical energy-driven nature of the EPSF process provide distinct advantages in environmental remediation and biomedical applications. Numerous studies on EPSF catalysts have emerged in recent years across these fields. However, the construction approaches and design strategies for EPSF catalysts in various application scenarios remain unclear. This review synthesizes and analyzes studies on organic pollutant degradation and targeted tumor therapy. Based on the elucidation of redox processes in EPSF catalysis, the catalysts are categorized according to structural features, clarifying common material systems across different fields. The factors influencing EPSF catalytic performance are subsequently outlined, followed by an evaluation of corresponding enhancement strategies. Finally, design strategies for EPSF catalysts across applications are analyzed, emphasizing the commonalities and distinctions in catalyst design for different fields. Insights are provided to inform future catalyst development.

Lung fibrosis (LF) is a serious complication with very limited therapeutic options. This study aimed to find a potential compound for targeting LF and develop a chitosome formulation to minimize any inherent drawbacks of the compound and achieve effective drug delivery. In total, 79 natural compounds were screened using an in silico approach against five targeted proteins (3HMG, 6B8Y, 2FAP, 3CQU, and 3DK9). Amongst these, quercetin (QER) exhibited the best efficacy (−14.725 kcal mol⁻¹) and ΔG average (−86.45 ± 6.24) kcal mol⁻¹ against the TGF-β receptor (PDB ID: 6B8Y). In vitro studies revealed that bleomycin-challenged A549 cells showed a fibrosis-like behaviour. Upon treatment with QER, the cell viability decreased owing to a reduction in the mitochondrial membrane potential and increased apoptosis. Furthermore, cell migration was inhibited with an improvement in cellular morphology. A QER-loaded chitosome formulation (QCF) was prepared through modified thin-film hydration. Variables were optimized using a response surface methodology Box–Behnken design. The QCF was further characterized on the basis of microscopic observation, zeta potential, entrapment efficiency, drug release and kinetics and by evaluating the effect of temperature on the QCF. Its zeta potential was +24.83 ± 0.32 mV, while microscopic observation showed that it had a spherical morphology with slightly rough surfaces after chitosan coating. Furthermore, the EE% was determined to be 81.75 ± 0.46%. The QCF also demonstrated a 74.23 ± 1.01% release of QER till 24 h, following Higuchi model kinetics. In conclusion, the in silico and in vitro cell line studies provided evidence for QER as a lead molecule for targeting LF. Moreover, the prepared QCF demonstrated sustained release with prospective QER targeted delivery. However, further extensive research is required to provide a promising strategy for the management of LF in the future.

Despite the recognized neuroprotective benefits of curcumin, its clinical utility is constrained by poor bioavailability and high cytotoxicity at effective doses. This study evaluates the therapeutic potential of curcumin-derived carbon quantum dots (Cur-CQDs) for retinal protection against ischemia-reperfusion (IR) injury in rats. Cur-CQDs were synthesized via mild pyrolysis at varying temperatures and assessed for efficacy in rat retinal ganglion cells and a model of retinal IR injury. The Cur-CQDs, particularly those synthesized at 150 °C, displayed significant reductions in apoptosis in retinal tissues, as indicated by TUNEL assays, immunofluorescence localization of HIF-α, CD68, BCL-2, and Grp78, and Western blot analysis for HO-1, Grp78, CHOP, caspase 3, and Nrf2. These results suggest that Cur-CQDs not only enhance cell survival and reduce inflammation but also decrease oxidative and endoplasmic reticulum stress markers. Mechanistic insights reveal that Cur-CQDs modulate pathways involved in oxidative stress, apoptosis, and inflammation, specifically through the upregulation of BCL-2 and HO-1 and the downregulation of CHOP, caspase-3, and endoplasmic reticulum stress markers. The identification of cinnamic acid-, anisole-, guaiacol, and ferulic acid-like structures on Cur-CQDs’ surfaces may contribute to their superior antioxidative and anti-inflammatory activities. Collectively, these findings position Cur-CQDs as a promising approach for treating retinal IR injuries, enhancing curcumin's bioavailability and therapeutic efficacy, and paving new pathways in ocular neuroprotection research and potential clinical applications.

Osteoarthritis (OA) is a widely encountered degenerative joint disorder marked by gradual cartilage deterioration, inflammation, and pain, which collectively impose considerable strain on global healthcare systems. While traditional therapies typically offer relief from symptoms, they do not tackle the core pathophysiological aspects of the disease. Regenerative medicine has recently risen as a promising field for addressing OA, capitalizing on the regenerative capabilities of stem cells and growth factors to foster tissue healing and renewal. This thorough review delves into the most recent progress in stem cell and growth factor treatments for OA, covering preclinical studies, clinical trials, and novel technological developments. We discuss the diverse origins of stem cells, such as mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and adipose-derived stem cells (ASCs), underscoring their therapeutic actions and effectiveness in both preclinical and clinical environments. Moreover, we explore contributions of growth factors like transforming growth factor (TGF)-β, platelet-derived growth factor (PDGF), and insulin-like growth factor (IGF) in modifying OA's pathology and enhancing tissue restoration. Additionally, this review discusses the hurdles and constraints tied to current regenerative strategies, including the standardization of cell sources, the refinement of delivery techniques, and considerations for long-term safety. By meticulously assessing the latest research outcomes and technological breakthroughs, this review aims to shed light on the potential of stem cell and growth factor therapies as forthcoming therapeutic options for OA, thereby propelling forward the domain of regenerative medicine and enhancing clinical results for individuals afflicted with this incapacitating ailment.

Time-sequenced drug release, or sequential drug release, represents a pivotal strategy in the synergistic treatment of diseases using nanocomposites. Achieving this requires the rational integration of multiple therapeutic agents within a single nanocomposite, coupled with precise time-controlled release mechanisms. These nanocomposites offer many advantages, including enhanced therapeutic synergy, reduced side effects, attenuated adverse interactions, improved stability and optimized drug utilization. Consequently, research in the field of drug delivery and synergistic therapy has become increasingly important. Currently, sequential drug release research is still in the data collection and basic research stages, and its potential has not yet been fully explored. Although prior studies have explored the sequential drug release strategy in various contexts, a comprehensive review of the underlying mechanisms and their applications in nanocomposites remains scarce. This review categorizes different types of sequential drug release strategies and summarizes diverse nanocomposites, focusing on both physical approaches driven by structural variations and chemical methods based on stimulus-responsive mechanisms. Furthermore, we highlight the major applications of sequential drug release strategies in the treatment of various diseases and detail their therapeutic efficacy. Finally, emerging trends and challenges in advancing sequential drug release strategies based on nanocomposites for disease treatment are also discussed.

Recently, Li, which can greatly enhance the mechanical characteristics of zinc alloys, Ag, which has antibacterial properties, and Sr, which promotes bone formation, have been widely applied in biodegradable alloys. However, to our knowledge, there has been no research on the combined effects of Ag, Li, and Sr in zinc alloys. To address this, we have created a new quaternary alloy (Zn–3Ag–0.1Li–0.1Sr). The incorporation of Ag, Li, and Sr increased the yield strength (YS) of the at-cast (AC) zinc alloy to 188.83 ± 12.38 MPa. After extrusion and hot rolling, the strong plasticity of the alloy was further significantly enhanced, with ultimate tensile strength (UTS) exceeding 400 MPa, YS exceeding 350 MPa, and elongation (EL) greater than 50%. An in vitro cell study revealed that after three days of culture with a 50% extract, the proliferation rate of MC3T3-E1 cells was 101.527 ± 0.129%, and the cells maintained a healthy spindle-shaped appearance. The antibacterial experiments also demonstrated that the Zn–3Ag–0.1Li–0.1Sr quaternary alloy has strong antibacterial properties against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Therefore, the biodegradable Zn–3Ag–0.1Li–0.1Sr quaternary alloy, which exhibits high strength, good cytocompatibility, and satisfactory antibacterial performance, has greater potential for application in the field of orthopedic repair.

Potentiometric ion sensors represent a significant subgroup of electrochemical sensors. In this study, we have developed a potentiometric sensor using an electrically conductive copolymer of 2,2′-bithiophene (BT) and 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) for the selective detection of Ca²⁺ ions in extracellular interstitial fluids. The integration of BAPTA with its highly selective calcium chelating properties into a polymer matrix via electrochemical polymerization results in a sensitive conductive polymer layer that effectively detects the presence of calcium ions. This sensor aims at the early detection of inflammation or infection around implants because local calcium concentration is strongly elevated in interstitial fluid in such pathologies. The potentiometric study proves the incorporation of BAPTA into the polymer matrix was successful and its potential decreased upon calcium binding demonstrating the Nernstian behavior with a slope of approximately 20 ± 0.3 mV per decade in the concentration range from 0.1 mM to 1 mM. Moreover, the selectivity coefficient of –0.4 was measured by SSM and calculated from the Nicolsky–Eisenmann equation, which indicates selectivity towards Ca²⁺ ions with respect to Mg²⁺ ions.

Liver fibrosis resulting from chronic liver injury is characterized by increased extracellular matrix deposition and inflammation, which leads to excessive scar tissue formation. Targeting activated hepatic stellate cells (HSCs), which are the primary drivers of fibrogenesis, stands out as one of the most compelling therapeutic approaches in this regard. In a healthy liver, HSCs remain quiescent and store vitamin A in cytoplasmic lipid droplets. As a consequence of HSC activation and transdifferentiation to a proliferative myofibroblast-like state upon fibrotic stimuli, the distinctive phenotypic feature of the lipid droplets gets lost. While the reversal of activated HSCs is feasible, understanding the quiescent-like state following injury resolution is crucial for effective fibrosis treatment. This study explores the induced quiescent-like state of naïve immortalized human hepatic stellate (LX-2) cells when treated with soybean phospholipid that contains 75% phosphatidylcholine (S80). The lipid profile of the newly formed lipid droplets was analyzed using Raman imaging, which is a label-free technique well-suited for lipidomics. Results indicate the presence of distinct lipid profiles despite maintaining a quiescent-like state, suggesting that diverse mechanisms govern the active-to-inactive state transition. Additionally, our findings support the fact that each hepatic cell state is composed of heterogeneous subpopulations. This emphasizes the complexity of liver fibrosis and highlights the need for a comprehensive understanding of cellular states to develop targeted therapies.

Luminescent peptide hydrogelators have garnered significant attention in biomedical sciences and materials chemistry due to their biological relevance and tunable photophysical features. In this work, we have designed and synthesized a novel ultrashort peptide hydrogelator comprising a tripeptide sequence (FFE) integrated with 1,8-naphthalimide (NI) as an aggregation-induced emissive unit having rich and tuneable photophysical properties. The hydrogelator could self-assemble and form a self-supporting hydrogel having a highly ordered intertwined network structure at pH 5.5 with a minimum gelation concentration of 1 wt/v%. Interestingly, due to the presence of the emissive unit, the assembly could demonstrate strong blue luminescence, which has been thoroughly investigated experimentally. Moreover, spectroscopic investigations and molecular dynamics simulation studies suggest the formation of a β-sheet structure through extended intermolecular H-bonding interactions within the peptide backbones and the strong π–π-stacking interaction among aromatic units, which drive the self-assembly and hydrogelation. The emissive unit of the peptide could arrange in a J-type aggregation pattern and adopt right-handed helical induced chirality in the assembled state. Additionally, the system could exhibit a high safety profile and excellent biocompatibility, when tested in a series of cell lines in vitro. Finally, the intracellular uptake of the system has been exploited, showcasing its luminescence characteristics for potential applications in cellular imaging. The luminescent system holds significant promise for advancing cellular imaging techniques, offering new avenues for research in the future. Briefly, this work highlights the importance of luminescent ultrashort peptide hydrogelators for developing next-generation low-cost functional biomaterials.

This review discusses the functionalization strategies of ZIF-8 and challenges and future developments in ZIF-8-based platforms for drug delivery and cancer therapy. We systematically evaluate a series of innovative ZIF-8 functionalization methods, including atomic doping, introduction of targeting molecules, and biomimetic mineralization technology, to achieve precise drug release. These functionalization strategies significantly enhance the targeted delivery and controlled release properties of ZIF-8, broaden the diversity of drug delivery systems, maximize therapeutic effects, and minimize systemic toxicity. In addition, this review explores the important role of ZIF-8 in tumor therapy. Its ability to encapsulate multiple therapeutic agents and its responsiveness to the tumor microenvironment significantly improve the therapeutic effect and reduce the side effects of traditional treatments. By integrating multiple therapeutic agents and performing surface modification, ZIF-8-based platforms may provide personalized and efficient treatment options for drug-resistant or recurrent cancers. This review also comprehensively discusses the synthesis methods, drug loading capacity, and potential clinical applications of ZIF-8, emphasizing the need to optimize its large-scale production and reproducibility. In addition, further studies on the long-term biocompatibility and biodegradability of ZIF-8-based systems are essential to ensure their safety in long-term treatment. In summary, this review highlights the structural advantages and significant therapeutic potential of ZIF-8 and calls for the transition of ZIF-8 from laboratory research to clinical application to provide more targeted, efficient, and friendly cancer treatment options.