Ita Susanti, Nur Asyiah Putri Helnasari, Maharani Maharani
Introduction: The basic immunization program organized by the Government is urgently needed for children aged 0-12 months. One of the reasons for the low coverage of complete basic immunization in the work area of the Montasik Health Center is the past experience of parents and families who have experienced Adverse Events after Immunization, then the next child they refuse to be re-immunized. This is because the parent gets pressure from the family and follows the advice the family more than health workers. Parents mentioned that the Adverse Events after Immunization is that are often experienced by infants include mild to severe fever, the baby has swelling at the injection site and seizures due to high fever after immunization. Methods: This cross-sectional was conducted in the working area of the Montasik Health Center on January, 2022. The population in this study was 178 people consisting of 30 villages, while the sampling technique was cluster random sampling, which was 53 people. Test analysis of research results using the chi-square test. Results: Most of the 12-month-old did not get complete basic immunization, (83.0%), 37 parents who have experience and did not complete basic immunization for their infants (75.7%). Parent’s experience and the provision of complete basic immunization in the work area of the Montasik Health Center Aceh Besar, the value was 0.028 (< 0.05). Conclusion: There is a relationship between parent’s experience with the provision of complete basic immunization in the work area of the Montasik Health Center, Aceh Besar District.
{"title":"Relationship between Parents’ Experience with Giving Complete Basic Immunization to Infants in The Working Area of the Montasik Health Center, Aceh Besar District","authors":"Ita Susanti, Nur Asyiah Putri Helnasari, Maharani Maharani","doi":"10.55561/ajhr.v1i3.60","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.60","url":null,"abstract":"Introduction: The basic immunization program organized by the Government is urgently needed for children aged 0-12 months. One of the reasons for the low coverage of complete basic immunization in the work area of the Montasik Health Center is the past experience of parents and families who have experienced Adverse Events after Immunization, then the next child they refuse to be re-immunized. This is because the parent gets pressure from the family and follows the advice the family more than health workers. Parents mentioned that the Adverse Events after Immunization is that are often experienced by infants include mild to severe fever, the baby has swelling at the injection site and seizures due to high fever after immunization.\u0000Methods: This cross-sectional was conducted in the working area of the Montasik Health Center on January, 2022. The population in this study was 178 people consisting of 30 villages, while the sampling technique was cluster random sampling, which was 53 people. Test analysis of research results using the chi-square test.\u0000Results: Most of the 12-month-old did not get complete basic immunization, (83.0%), 37 parents who have experience and did not complete basic immunization for their infants (75.7%). Parent’s experience and the provision of complete basic immunization in the work area of the Montasik Health Center Aceh Besar, the value was 0.028 (< 0.05).\u0000Conclusion: There is a relationship between parent’s experience with the provision of complete basic immunization in the work area of the Montasik Health Center, Aceh Besar District.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"1905 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87713432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Endometriosis is the most common disease that affects the reproductive health and function of women of reproductive age. Treatment for endometriosis includes surgery and medication. Phaleria macrocarpa is a plant native to Indonesia that contains bioactive fractions known to have antiproliferative and apoptotic effects. Therefore, this study aimed to evaluate the effect of Phaleria macrocarpa extract on matrix metalloproteinases (MMP-2 and MMP-9) and NF-KB expression in the endometriosis mice model (Mus musculus). Methods: This study used a Randomized Post-Test Only with Control Group Design. Involves six groups, namely a negative control group (healthy mice without flavonoids from Phaleria macrocarpa fruit extract), a positive control group (an endometriosis model without being given flavonoids from Phaleria macrocarpa fruit extract), and a treatment group, namely a group given four different doses of flavonoids from Phaleria macrocarpa fruit extract: 3.75 milligrams per day, 7.5 milligrams per day, 11.25 milligrams per day and 15 milligrams per day. expressions of NF-KB, MMP-2, and MMP-9 were seen using Immunohistochemistry staining and observed under a microscope with 40x magnification. The data collection used an immunoratio technique with ImageJ analysis software. Furthermore, data analysis using the one-way ANOVA method. Results: In this study, the treatment group with four different doses of Phaleria macrocarpa extract could reduce the expression of MMP-2, MMP-9, and NF-KB. Groups with higher doses of Phaleria macrocarpa extract showed lessen of MMP-2, MMP-9, and NF-KB expression. Conclusion: In the endometriosis mice model, Phaleria macrocarpa fruit can reduce NF-KB, MMP-2, and MMP-9 expression.
{"title":"Effect of Phaleria macrocarpa Extract on NF-KB, MMP-2, and MMP-9 Expression in Endometriosis Mice Model","authors":"Annisa Febriani, S. Sutrisno, Yahya Irwanto, Irfani Baihaqi, Wayan Arsana Wiyasa, Bambang Rahardjo","doi":"10.55561/ajhr.v1i3.35","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.35","url":null,"abstract":"Introduction: Endometriosis is the most common disease that affects the reproductive health and function of women of reproductive age. Treatment for endometriosis includes surgery and medication. Phaleria macrocarpa is a plant native to Indonesia that contains bioactive fractions known to have antiproliferative and apoptotic effects. Therefore, this study aimed to evaluate the effect of Phaleria macrocarpa extract on matrix metalloproteinases (MMP-2 and MMP-9) and NF-KB expression in the endometriosis mice model (Mus musculus).\u0000Methods: This study used a Randomized Post-Test Only with Control Group Design. Involves six groups, namely a negative control group (healthy mice without flavonoids from Phaleria macrocarpa fruit extract), a positive control group (an endometriosis model without being given flavonoids from Phaleria macrocarpa fruit extract), and a treatment group, namely a group given four different doses of flavonoids from Phaleria macrocarpa fruit extract: 3.75 milligrams per day, 7.5 milligrams per day, 11.25 milligrams per day and 15 milligrams per day. expressions of NF-KB, MMP-2, and MMP-9 were seen using Immunohistochemistry staining and observed under a microscope with 40x magnification. The data collection used an immunoratio technique with ImageJ analysis software. Furthermore, data analysis using the one-way ANOVA method.\u0000Results: In this study, the treatment group with four different doses of Phaleria macrocarpa extract could reduce the expression of MMP-2, MMP-9, and NF-KB. Groups with higher doses of Phaleria macrocarpa extract showed lessen of MMP-2, MMP-9, and NF-KB expression.\u0000Conclusion: In the endometriosis mice model, Phaleria macrocarpa fruit can reduce NF-KB, MMP-2, and MMP-9 expression.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"29 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74995419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare mesenchymal tumor that occurs in less than 1% of all cervical cancers. These malignant tumors occur in adolescents and young adults. It starts from embryonic muscle tissue or pluripotent mesenchymal cells. This case reports an unusual case of embryonal rhabdomyosarcoma in a 33-year-old woman. Case Presentation: A 33-year-old woman came to the Obstetrics and Gynecology Department. She complained with exophytic cervical masses and vaginal bleeding. There were no remarkable findings about medical, family, and social history Histopathology confirms embryonal rhabdomyosarcoma (sarcoma botryoides) of the uterine cervix. A combination of radical hysterectomy and adjuvant chemotherapy was chosen as the therapeutic option in this case. Conclusion: Although the prevalence of cervical rhabdomyosarcoma in adults is very low, a multimodality approach is necessary for favorable prognostic.
{"title":"Rhabdomyosarcoma of The Uterine Cervix: Case Report and Literature Review","authors":"T. Nurseta, Ayu Rizky Widowati","doi":"10.55561/ajhr.v2i2.118","DOIUrl":"https://doi.org/10.55561/ajhr.v2i2.118","url":null,"abstract":"Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare mesenchymal tumor that occurs in less than 1% of all cervical cancers. These malignant tumors occur in adolescents and young adults. It starts from embryonic muscle tissue or pluripotent mesenchymal cells. This case reports an unusual case of embryonal rhabdomyosarcoma in a 33-year-old woman.\u0000Case Presentation: A 33-year-old woman came to the Obstetrics and Gynecology Department. She complained with exophytic cervical masses and vaginal bleeding. There were no remarkable findings about medical, family, and social history Histopathology confirms embryonal rhabdomyosarcoma (sarcoma botryoides) of the uterine cervix. A combination of radical hysterectomy and adjuvant chemotherapy was chosen as the therapeutic option in this case.\u0000Conclusion: Although the prevalence of cervical rhabdomyosarcoma in adults is very low, a multimodality approach is necessary for favorable prognostic.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"61 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86704115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fikhy rizky Hapsari, Suheni Ninik Hariyati, I. Wiyasa, Teguh Wiyono, Dewi Santosaningsih
Introduction: Infection is the biggest cause of preterm labor, about 25-40%, and ascending infection through the vagina is the most common route of infection. This study aims to evaluate the level of Low Molecular Weight Hyaluronan (LMWHA), level of High Molecular Weight Hyaluronan (HMWHA), and the level of the enzyme hyaluronidase in Balb/c premature labor due to infection with Escherichia coli model mice. Methods: This study used an actual experimental design carried out in the laboratory in vivo on balb/c mice exposure to Escherichia coli with a randomized post-test only with a control group design. In the premature model of exposure to Escherichia coli balb/c mice on the cervix of 109 CFU/ml, cervical samples were taken and the levels of LMWHA, HMWHA, and hyaluronidase were measured using spectrophotometry. This study was divided into 2 groups. Control group and treatment group. Results: Low Molecular Weight Hyaluronan (LMWHA) and of the hyaluronidase enzyme levels in premature Balb/C cervical mice exposed to E. coli were higher than in Balb/C cervical mice. High Molecular Weight Hyaluronan (HMWHA) levels in premature Balb/C cervical mice exposed to E. coli were lower Conclusion: In the cervix of the infected by E. coli mice model, LMWHA and hyaluronidase enzymes increased and HMWHA decreased.
{"title":"The Effect of Exposure to Escherichia coli with Low Molecular Weight Hyaluronan, High Molecular Weight Hyaluronan, Hyaluronidase in the Cervix Premature Pregnant Model of Balb/C Mice","authors":"Fikhy rizky Hapsari, Suheni Ninik Hariyati, I. Wiyasa, Teguh Wiyono, Dewi Santosaningsih","doi":"10.55561/ajhr.v1i3.56","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.56","url":null,"abstract":"Introduction: Infection is the biggest cause of preterm labor, about 25-40%, and ascending infection through the vagina is the most common route of infection. This study aims to evaluate the level of Low Molecular Weight Hyaluronan (LMWHA), level of High Molecular Weight Hyaluronan (HMWHA), and the level of the enzyme hyaluronidase in Balb/c premature labor due to infection with Escherichia coli model mice.\u0000Methods: This study used an actual experimental design carried out in the laboratory in vivo on balb/c mice exposure to Escherichia coli with a randomized post-test only with a control group design. In the premature model of exposure to Escherichia coli balb/c mice on the cervix of 109 CFU/ml, cervical samples were taken and the levels of LMWHA, HMWHA, and hyaluronidase were measured using spectrophotometry. This study was divided into 2 groups. Control group and treatment group.\u0000Results: Low Molecular Weight Hyaluronan (LMWHA) and of the hyaluronidase enzyme levels in premature Balb/C cervical mice exposed to E. coli were higher than in Balb/C cervical mice. High Molecular Weight Hyaluronan (HMWHA) levels in premature Balb/C cervical mice exposed to E. coli were lower\u0000Conclusion: In the cervix of the infected by E. coli mice model, LMWHA and hyaluronidase enzymes increased and HMWHA decreased.\u0000 \u0000 ","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"16 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78806739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adin Permana, Mukhamad Nooryanto, I. Indrawan, Cholid Rohman Riskianto
Introduction: Continuous SLE treatment causes Premature Ovarian Failure (POF) and occurred in 27.3% SLE patients treated with cyclophosphamide. IL-6 plays a critical role in the B cell hyperactivity and immunopathology of human SLE. Phaseolus Vulgaris L. Sp have a high total phenolic content and have been shown to have anti-inflammatory and antioxidant effects. This study’s objective is to prove the effect of red beans (Phaseoulus vulgaris L. sp.) in reducing inflammation (IL-6) and increasing AMH levels. Methods: This is a true experimental design with a post-test-only controlled group design. The sample used in this study was 25 female Babic mice divided in two control groups and three treatment groups. Subjects were given intraperitoneal injection of Pristan (0.5 ml), busulfan (30 mg/kg BW), cyclophosphamide (120 mg/kg BW) to induce POF. ANA test was carried out to prone SLE induction was success. Red bean extract was given at 50 mg/kg BW (in treatment group 1), 75 mg/kg BW (in treatment group 2), and 100 mg/kg BW (in treatment group 3). Data of IL-6 and AMH levels in mice serum were obtained by measurement using ELISA. Results: The study showed a significant difference in ANA levels with a p-value of 0.000 in every sample. The study has proven a significant decrease in IL-6 levels with a p-value of 0.000 and a significant increase in AMH levels at a dose of 100 mg/kg BW (P3) with a p-value of 0.000. Conclusion: Phaseolus vulgaris extract had a significant effect on follicle changes in Balb/c mice in dose of 50 mg/kg and 75 mg/kg but not significantly reduce inflammation (IL-6).
{"title":"Effect of Red Bean Extract (Phaseolus Vulgaris L. Sp) on Il-6 Levels and AMH Levels as The Prevention of Premature Ovarian Failure in Mice Model of The Systemic Lupus Erythematosus","authors":"Adin Permana, Mukhamad Nooryanto, I. Indrawan, Cholid Rohman Riskianto","doi":"10.55561/ajhr.v1i3.51","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.51","url":null,"abstract":"Introduction: Continuous SLE treatment causes Premature Ovarian Failure (POF) and occurred in 27.3% SLE patients treated with cyclophosphamide. IL-6 plays a critical role in the B cell hyperactivity and immunopathology of human SLE. Phaseolus Vulgaris L. Sp have a high total phenolic content and have been shown to have anti-inflammatory and antioxidant effects. This study’s objective is to prove the effect of red beans (Phaseoulus vulgaris L. sp.) in reducing inflammation (IL-6) and increasing AMH levels.\u0000Methods: This is a true experimental design with a post-test-only controlled group design. The sample used in this study was 25 female Babic mice divided in two control groups and three treatment groups. Subjects were given intraperitoneal injection of Pristan (0.5 ml), busulfan (30 mg/kg BW), cyclophosphamide (120 mg/kg BW) to induce POF. ANA test was carried out to prone SLE induction was success. Red bean extract was given at 50 mg/kg BW (in treatment group 1), 75 mg/kg BW (in treatment group 2), and 100 mg/kg BW (in treatment group 3). Data of IL-6 and AMH levels in mice serum were obtained by measurement using ELISA.\u0000Results: The study showed a significant difference in ANA levels with a p-value of 0.000 in every sample. The study has proven a significant decrease in IL-6 levels with a p-value of 0.000 and a significant increase in AMH levels at a dose of 100 mg/kg BW (P3) with a p-value of 0.000.\u0000Conclusion: Phaseolus vulgaris extract had a significant effect on follicle changes in Balb/c mice in dose of 50 mg/kg and 75 mg/kg but not significantly reduce inflammation (IL-6).","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"17 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78030560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Deficit in trace elements was frequent in pregnant women and could lead to preeclampsia development. This meta-analysis aimed to determine calcium, magnesium, zinc, iron, and copper serum levels in preeclampsia women compared to healthy pregnant women. Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar from inception into March 25th, 2022 using keywords of “("calcium" OR "magnesium" OR "zinc" OR "copper" OR "iron" OR "trace element" OR "trace elements") AND ("serum" OR "blood") AND ("preeclampsia")”. Articles obtained from PubMed, ScienceDirect, and Google Scholar were 62, 31, and 119 respectively. The article screening process was based on the PRISMA 2020 guidelines. Study quality was assessed using NOS. Results: Fifty-four studies were included in this systematic review. Pooled analysis revealed that serum calcium (SMD = (-1.66; 95% CI = -2.05 to -1.28, magnesium (SMD = -1.28; 95% CI = -1.37 to -1.20, and zinc were significantly lower in preeclampsia (SMD = -2.4; 95% CI = -4.11 to -0.7. Serum iron was higher in preeclampsia (SMD = 1.71; 95% CI = 0.21 to 3.21). No significant different difference in serum copper level. Conclusion: The mean blood levels of calcium, magnesium, and zinc were considerably lower, while blood iron levels were higher in preeclamptic women compared to the healthy pregnant group. Copper levels were not significantly different between the two groups.
微量元素缺乏在孕妇中是常见的，可能导致先兆子痫的发展。本荟萃分析旨在测定子痫前期妇女与健康孕妇相比的钙、镁、锌、铁和铜的血清水平。方法:从启动到2022年3月25日，在PubMed、ScienceDirect和Google Scholar中以“钙”或“镁”或“锌”或“铜”或“铁”或“微量元素”或“微量元素”、“血清”或“血液”、“子痫前期”等关键词进行系统检索。来自PubMed、ScienceDirect和Google Scholar的文章分别为62篇、31篇和119篇。文章筛选过程基于PRISMA 2020指南。研究质量采用nos进行评估。结果:本系统综述纳入54项研究。合并分析显示血清钙(SMD = (-1.66;95% CI = -2.05 ~ -1.28，镁(SMD = -1.28;95% CI = -1.37 ~ -1.20，锌在子痫前期显著降低(SMD = -2.4;95% CI = -4.11 ~ -0.7。子痫前期血清铁含量较高(SMD = 1.71;95% CI = 0.21 ~ 3.21)。血清铜水平差异无统计学意义。结论:与健康孕妇组相比，子痫前期妇女的平均血钙、镁和锌水平明显较低，而血铁水平较高。两组之间的铜含量没有显著差异。
{"title":"Maternal Blood Trace Element Levels in Preeclampsia: Comprehensive Systematic Review and Meta-Analysis","authors":"Wening Hapsari, Achmad Januar Er Putra","doi":"10.55561/ajhr.v1i3.42","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.42","url":null,"abstract":"Introduction: Deficit in trace elements was frequent in pregnant women and could lead to preeclampsia development. This meta-analysis aimed to determine calcium, magnesium, zinc, iron, and copper serum levels in preeclampsia women compared to healthy pregnant women.\u0000Methods: A systematic search is conducted in PubMed, ScienceDirect, and Google Scholar from inception into March 25th, 2022 using keywords of “(\"calcium\" OR \"magnesium\" OR \"zinc\" OR \"copper\" OR \"iron\" OR \"trace element\" OR \"trace elements\") AND (\"serum\" OR \"blood\") AND (\"preeclampsia\")”. Articles obtained from PubMed, ScienceDirect, and Google Scholar were 62, 31, and 119 respectively. The article screening process was based on the PRISMA 2020 guidelines. Study quality was assessed using NOS.\u0000Results: Fifty-four studies were included in this systematic review. Pooled analysis revealed that serum calcium (SMD = (-1.66; 95% CI = -2.05 to -1.28, magnesium (SMD = -1.28; 95% CI = -1.37 to -1.20, and zinc were significantly lower in preeclampsia (SMD = -2.4; 95% CI = -4.11 to -0.7. Serum iron was higher in preeclampsia (SMD = 1.71; 95% CI = 0.21 to 3.21). No significant different difference in serum copper level.\u0000Conclusion: The mean blood levels of calcium, magnesium, and zinc were considerably lower, while blood iron levels were higher in preeclamptic women compared to the healthy pregnant group. Copper levels were not significantly different between the two groups.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"7 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78432671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Menopause is defined by a decline in estrogen levels, which causes various symptoms. Treatments based on foods or supplements enriched in phytoestrogens, notably isoflavones, plant-derived compounds with estrogenic effects, have recently become quite popular. This study aims to see how effective non-soy isoflavone supplementation is for menopausal symptoms in women. Methods: 26 menopausal women were given 67.5 mg of non-soy isoflavone, and 25 menopausal women were given a placebo daily for 12 weeks in an analytical double-blind, randomized clinical trial (RCT). Inclusion criteria were (1) RCT, (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral non-soy isoflavone. Symptoms Severity Score (SSS) based on the Kupperman index (KI) questionnaire was administered to the patients before starting and at the end of the study. The Statistical Package for Social Sciences (SPSS) software was used to analyze the responses. Results: The difference in SSS scores between the treatment and control groups was significant (p = 0.000). Women receiving 67.5 mg of non-soy isoflavone daily, reduced myalgia, fatigue, and hot flushes by 92.3%, 77%, and 53.8%, respectively. For clinical significance rating, relative risk reduction (RRR) is used. A significant RRR value resulted from myalgia symptoms (76.6%), fatigue (55.7%), hot flushes (39.2%), and SSS (68.7%). Conclusion: Isoflavones did not bring a significant change in Kupperman Index compared to placebo but provided significantly improved Symptoms Severity Scoring in menopausal women.
引言:绝经是由雌激素水平下降而引起的各种症状所定义的。以富含植物雌激素的食物或补品为基础的治疗，特别是异黄酮，具有雌激素作用的植物来源化合物，最近变得相当流行。本研究旨在了解非大豆异黄酮补充剂对女性更年期症状的效果。方法:在一项分析性双盲随机临床试验(RCT)中，26名绝经妇女每天服用67.5 mg非大豆异黄酮，25名绝经妇女每天服用安慰剂，持续12周。纳入标准为:(1)随机对照试验，(2)围绝经期或绝经后出现更年期症状的妇女，(3)口服非大豆异黄酮干预。在研究开始前和研究结束时对患者进行基于Kupperman指数(KI)问卷的症状严重程度评分(SSS)。采用SPSS (Statistical Package for Social Sciences)软件对调查结果进行分析。结果:治疗组与对照组SSS评分差异有统计学意义(p = 0.000)。每天摄入67.5毫克非大豆异黄酮的女性，分别减少了92.3%、77%和53.8%的肌痛、疲劳和潮热。临床意义评分采用相对风险降低(relative risk reduction, RRR)。肌痛症状(76.6%)、疲劳(55.7%)、潮热(39.2%)和SSS(68.7%)导致显著的RRR值。结论:与安慰剂相比，异黄酮没有带来Kupperman指数的显著变化，但显著改善了更年期妇女的症状严重程度评分。
{"title":"Efficacy of Non-Soy Isoflavone (Pueraria phaseoloides) on The Symptoms Severity Scoring by Kupperman Index in Menopausal Women","authors":"M. Tangkas, W. Ngartjono, A. Hidayat, L. Farida","doi":"10.55561/ajhr.v1i3.1","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.1","url":null,"abstract":"Introduction: Menopause is defined by a decline in estrogen levels, which causes various symptoms. Treatments based on foods or supplements enriched in phytoestrogens, notably isoflavones, plant-derived compounds with estrogenic effects, have recently become quite popular. This study aims to see how effective non-soy isoflavone supplementation is for menopausal symptoms in women.\u0000Methods: 26 menopausal women were given 67.5 mg of non-soy isoflavone, and 25 menopausal women were given a placebo daily for 12 weeks in an analytical double-blind, randomized clinical trial (RCT). Inclusion criteria were (1) RCT, (2) perimenopausal or postmenopausal women experiencing menopausal symptoms, (3) intervention with an oral non-soy isoflavone. Symptoms Severity Score (SSS) based on the Kupperman index (KI) questionnaire was administered to the patients before starting and at the end of the study. The Statistical Package for Social Sciences (SPSS) software was used to analyze the responses.\u0000Results: The difference in SSS scores between the treatment and control groups was significant (p = 0.000). Women receiving 67.5 mg of non-soy isoflavone daily, reduced myalgia, fatigue, and hot flushes by 92.3%, 77%, and 53.8%, respectively. For clinical significance rating, relative risk reduction (RRR) is used. A significant RRR value resulted from myalgia symptoms (76.6%), fatigue (55.7%), hot flushes (39.2%), and SSS (68.7%).\u0000Conclusion: Isoflavones did not bring a significant change in Kupperman Index compared to placebo but provided significantly improved Symptoms Severity Scoring in menopausal women.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"21 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73726963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nirwan Nugraha, Suheni Ninik Hariyati, D. Gunawan, Mokhammad Nooryanto, Pande Made Dwijayasa
Introduction: Premature birth is a global problem in various countries worldwide. The pathogenesis leading to preterm labor may occur in early pregnancy and is associated with inflammatory pathways and changes in the angiogenic process. Decorin and biglycan are hypothesized to play a role in pregnancy maintenance, wherein preterm delivery, these levels are thought to be reduced. This study was examined effect of Escherichia coli on Decorin and Type I Collagen levels in fetal membranes of Premature Balb/c Mice Methods: There were 28 pregnant Balb/c mice divided into 4 groups, with a post-test-only control group design in true experimental design research. The first control group (N1) was a group of pregnant mice dissected on day-15, while the second control group (N2) were mice pregnant at term followed up to parturition. Group P1 were given Escherichia coli 1x109 CFU/ ml dose on the cervix on day-15, while the second treatment group (P2) were given Escherichia coli in the cervical canal on day-15 followed by delivery. We examined the Decorin and Type I Collagen levels between group. One-way ANOVA was used to analyze the collected data. Results: There was a significant difference in the mean decorin levels between the control group N1 vs P2 (12.35±2.24 ng/mL vs 6.62±1.50 ng/mL; p=0.000). In addition, a significant difference was also found in the mean level of type 1 collagen between the control group N1 vs P2 group (283.5±31.3 ng/mL vs 170.6±38.8 ng/mL; p=0.000). Conclusion: A decrease in decorin levels affects the reduction in collagen type 1 levels in fetal membranes of Balb/C mice in premature models.
前言:早产在世界各国都是一个全球性的问题。导致早产的发病机制可能发生在妊娠早期，与炎症途径和血管生成过程的改变有关。据推测，Decorin和biglycan在妊娠维持中发挥作用，其中早产，这些水平被认为是降低的。本研究旨在探讨大肠杆菌对早熟Balb/c小鼠胎膜中Decorin和I型胶原蛋白水平的影响。方法:将28只Balb/c妊娠小鼠分为4组，采用单纯试验后对照组设计，为真正的实验设计研究。第一对照组(N1)为第15天解剖的妊娠小鼠，第二对照组(N2)为足月妊娠随访至分娩的小鼠。P1组于第15天宫颈上给予大肠杆菌1x109 CFU/ ml剂量，第二治疗组(P2)于分娩后第15天宫颈管内给予大肠杆菌。检测各组间Decorin和I型胶原蛋白水平。采用单因素方差分析对收集的数据进行分析。结果:对照组N1组与P2组的平均decorin水平差异有统计学意义(12.35±2.24 ng/mL vs 6.62±1.50 ng/mL);p = 0.000)。此外，对照组N1组与P2组的1型胶原平均水平也有显著差异(283.5±31.3 ng/mL vs 170.6±38.8 ng/mL);p = 0.000)。结论:decorin水平的降低影响Balb/C小鼠胎膜1型胶原水平的降低。
{"title":"Effect of Escherichia Coli on Decorin and Type I Collagen Levels in Fetal Membranes of Premature Balb/c Mice","authors":"Nirwan Nugraha, Suheni Ninik Hariyati, D. Gunawan, Mokhammad Nooryanto, Pande Made Dwijayasa","doi":"10.55561/ajhr.v1i3.26","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.26","url":null,"abstract":"Introduction: Premature birth is a global problem in various countries worldwide. The pathogenesis leading to preterm labor may occur in early pregnancy and is associated with inflammatory pathways and changes in the angiogenic process. Decorin and biglycan are hypothesized to play a role in pregnancy maintenance, wherein preterm delivery, these levels are thought to be reduced. This study was examined effect of Escherichia coli on Decorin and Type I Collagen levels in fetal membranes of Premature Balb/c Mice\u0000Methods: There were 28 pregnant Balb/c mice divided into 4 groups, with a post-test-only control group design in true experimental design research. The first control group (N1) was a group of pregnant mice dissected on day-15, while the second control group (N2) were mice pregnant at term followed up to parturition. Group P1 were given Escherichia coli 1x109 CFU/ ml dose on the cervix on day-15, while the second treatment group (P2) were given Escherichia coli in the cervical canal on day-15 followed by delivery. We examined the Decorin and Type I Collagen levels between group. One-way ANOVA was used to analyze the collected data.\u0000Results: There was a significant difference in the mean decorin levels between the control group N1 vs P2 (12.35±2.24 ng/mL vs 6.62±1.50 ng/mL; p=0.000). In addition, a significant difference was also found in the mean level of type 1 collagen between the control group N1 vs P2 group (283.5±31.3 ng/mL vs 170.6±38.8 ng/mL; p=0.000).\u0000Conclusion: A decrease in decorin levels affects the reduction in collagen type 1 levels in fetal membranes of Balb/C mice in premature models.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"40 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88476086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Probo Yudha Pratama Putra, Aida Musyarrofah, D. Pravitasari, Yulia Nugrahanitya
Introduction: General Pustular psoriasis pregnancy (GPPP) is a dermatosis that occurs in pregnancy and requires serious management to reduce the risk of mortality and morbidity in both pregnancy mother and fetus. This disorder is also called impetigo herpetiform. Case Presentation: We report a woman with multiple pregnancies, G3P2A0 at 21 weeks gestation, with well-defined erythematous macules 5–10 cm in diameter, partly coalescent, with thick scales, and 0.1–0.2 cm diameter pustules and leukocytosis. Patients receive 1 mg of dexamethasone every morning, clobetasol cream 0.05% twice daily, gentamycin 0.1% three times daily, and 3% salicylic acid cream, while to avoid the emergence of preeclampsia aspirin is given at a low dose of 75 mg/day, and we use vipalbumin to treat hypoalbuminemia. The patient gave birth to premature twins by normal delivery. Conclusion: GPPP is a rare dermatosis with serious risks and consequences for both mother and child. Supportive management is needed to maintain pregnancy and prevent complications.
{"title":"Case Report: Generalize Pustular Psoriasis Pregnancy (GPPP) in Multiple Pregnancies","authors":"Probo Yudha Pratama Putra, Aida Musyarrofah, D. Pravitasari, Yulia Nugrahanitya","doi":"10.55561/ajhr.v1i3.34","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.34","url":null,"abstract":"Introduction: General Pustular psoriasis pregnancy (GPPP) is a dermatosis that occurs in pregnancy and requires serious management to reduce the risk of mortality and morbidity in both pregnancy mother and fetus. This disorder is also called impetigo herpetiform.\u0000Case Presentation: We report a woman with multiple pregnancies, G3P2A0 at 21 weeks gestation, with well-defined erythematous macules 5–10 cm in diameter, partly coalescent, with thick scales, and 0.1–0.2 cm diameter pustules and leukocytosis. Patients receive 1 mg of dexamethasone every morning, clobetasol cream 0.05% twice daily, gentamycin 0.1% three times daily, and 3% salicylic acid cream, while to avoid the emergence of preeclampsia aspirin is given at a low dose of 75 mg/day, and we use vipalbumin to treat hypoalbuminemia. The patient gave birth to premature twins by normal delivery.\u0000Conclusion: GPPP is a rare dermatosis with serious risks and consequences for both mother and child. Supportive management is needed to maintain pregnancy and prevent complications.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"13 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72750019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Polycystic Ovary Syndrome (PCOS) is the most common causes of infertility in reproductive age women. The lack of knowledge about this disease causes PCOS is often late diagnosed. This study aims to determine the influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors in early screening efforts for PCOS. Methods: This is a pre-experimental study with one-group pretest-posttest design. The sample used was 261 female students in one of the senior high schools in Denpasar with a simple random sampling technique. The research instrument used is a questionnaire in which each variable, namely the knowledge, attitude, and the behavioral. The data was analyzed by using the Wilcoxon Rank Test. Results: There was a significant change between the provision of health promotion in the form of video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening in each variable, i.e. the knowledge variable p-value = 0.001, the attitude variable p-value <0.001, and the behavior variable p-value <0.001. Conclusion: There was an influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening.
{"title":"The Influence of Video-Based Health Education in Modifying Early Screening Efforts for Polycystic Ovary Syndrome (PCOS)","authors":"N. Ariani, N. Susanti, N. Parwati, N. Haryati","doi":"10.55561/ajhr.v1i3.54","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.54","url":null,"abstract":"Introduction: Polycystic Ovary Syndrome (PCOS) is the most common causes of infertility in reproductive age women. The lack of knowledge about this disease causes PCOS is often late diagnosed. This study aims to determine the influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors in early screening efforts for PCOS.\u0000Methods: This is a pre-experimental study with one-group pretest-posttest design. The sample used was 261 female students in one of the senior high schools in Denpasar with a simple random sampling technique. The research instrument used is a questionnaire in which each variable, namely the knowledge, attitude, and the behavioral. The data was analyzed by using the Wilcoxon Rank Test.\u0000Results: There was a significant change between the provision of health promotion in the form of video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening in each variable, i.e. the knowledge variable p-value = 0.001, the attitude variable p-value <0.001, and the behavior variable p-value <0.001.\u0000Conclusion: There was an influence of health promotion in video-based learning form on young women’s knowledge, attitudes and behaviors related to the PCOS early screening.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"64 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81421971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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