Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_59_23
Payal Mittal, Shristi Gupta, GirishChandra Arya
Objective: This study aimed to evaluate the anticonvulsant potential of phytochemicals from Acacia farnesiana using molecular docking and compare their binding affinities with ethosuximide, a common anticonvulsant. Additionally, we conducted a comprehensive ADMET analysis of leucoxol, a promising phytochemical with strong docking scores against leucine-rich glioma-inactivated protein 1 (PDB ID-5Y30). Methods: Auto Dock Vina was employed for in silico analysis to predict binding affinities. Leucoxol exhibited significantly higher binding affinity (-7.9 kcal/mol) than ethosuximide (-4.9 kcal/mol), suggesting superior anticonvulsant potential. We thoroughly examined leucoxol’s ADMET profile to assess its pharmacokinetic and toxicological properties. Results: Comparative analysis indicated that leucoxol may be a more effective anticonvulsant with reduced toxicity compared to ethosuximide. It displayed strong binding and a favorable ADMET profile. Conclusion: Phytochemicals from Acacia farnesiana, especially leucoxol, exhibit promising binding affinities compared to ethosuximide, indicating their potential as anticonvulsant agents. Leucoxol, in particular, demonstrates strong anticonvulsant potential and a favorable ADMET profile, making it a candidate for further research as an anticonvulsant with reduced toxicity. However, additional experimental and clinical investigations are needed to confirm their efficacy and safety in treating convulsive disorders.
目的:利用分子对接的方法评价金合欢植物化学物质的抗惊厥潜能，并比较其与常用的抗惊厥药乙氧亚胺的结合亲和力。此外，我们对亮醇进行了全面的ADMET分析，亮醇是一种很有前景的植物化学物质，与富含亮氨酸的胶质瘤失活蛋白1 (PDB ID-5Y30)有很强的对接评分。方法:采用Auto Dock Vina进行计算机分析，预测其结合亲和力。亮木醇的结合亲和力(-7.9 kcal/mol)明显高于乙氧亚胺(-4.9 kcal/mol)，表明亮木醇具有更强的抗惊厥潜能。我们彻底检查了亮醇的ADMET谱，以评估其药代动力学和毒理学特性。结果:对比分析表明，与乙氧亚胺相比，乙酰氨基酚可能是一种更有效的抗惊厥药，且毒性更低。它具有很强的结合性和良好的ADMET谱。结论:金合欢中的植物化学物质，特别是白木酚，与乙氧亚胺相比，具有良好的结合亲和力，表明其具有抗惊厥药物的潜力。特别是亮木醇，显示出强大的抗惊厥潜力和良好的ADMET谱，使其成为进一步研究的候选抗惊厥药，具有降低毒性。然而，需要进一步的实验和临床研究来证实其治疗惊厥疾病的有效性和安全性。
{"title":"Computational insights into the epilepsy-related phytoconstituents of <i>Acacia farnesiana</i>: <i>In silico</i> analysis, molecular modeling, and ADMET profiling","authors":"Payal Mittal, Shristi Gupta, GirishChandra Arya","doi":"10.4103/ajprhc.ajprhc_59_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_59_23","url":null,"abstract":"Objective: This study aimed to evaluate the anticonvulsant potential of phytochemicals from Acacia farnesiana using molecular docking and compare their binding affinities with ethosuximide, a common anticonvulsant. Additionally, we conducted a comprehensive ADMET analysis of leucoxol, a promising phytochemical with strong docking scores against leucine-rich glioma-inactivated protein 1 (PDB ID-5Y30). Methods: Auto Dock Vina was employed for in silico analysis to predict binding affinities. Leucoxol exhibited significantly higher binding affinity (-7.9 kcal/mol) than ethosuximide (-4.9 kcal/mol), suggesting superior anticonvulsant potential. We thoroughly examined leucoxol’s ADMET profile to assess its pharmacokinetic and toxicological properties. Results: Comparative analysis indicated that leucoxol may be a more effective anticonvulsant with reduced toxicity compared to ethosuximide. It displayed strong binding and a favorable ADMET profile. Conclusion: Phytochemicals from Acacia farnesiana, especially leucoxol, exhibit promising binding affinities compared to ethosuximide, indicating their potential as anticonvulsant agents. Leucoxol, in particular, demonstrates strong anticonvulsant potential and a favorable ADMET profile, making it a candidate for further research as an anticonvulsant with reduced toxicity. However, additional experimental and clinical investigations are needed to confirm their efficacy and safety in treating convulsive disorders.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_15_23
KeshaAjaykumar Parmar, Maulin Mehta
Various malignancies, autoimmune disorders such as rheumatoid arthritis (RA), and elective abortions commonly use methotrexate (MTX) for their treatment, which is a folate antagonist. Although many cases of the common side effects of MTX such as nausea, vomiting, and stomatitis have been reported, very few cases of MTX-induced neutropenia have been found in the literature. We have taken a case of neutropenia that developed after the patient took tablet MTX for RA. The case was studied and the causality assessment of the reported adverse drug reaction showed it to be in the category of “probable” according to the WHO-UMC causality categories.
{"title":"Methotrexate-induced Neutropenia","authors":"KeshaAjaykumar Parmar, Maulin Mehta","doi":"10.4103/ajprhc.ajprhc_15_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_15_23","url":null,"abstract":"Various malignancies, autoimmune disorders such as rheumatoid arthritis (RA), and elective abortions commonly use methotrexate (MTX) for their treatment, which is a folate antagonist. Although many cases of the common side effects of MTX such as nausea, vomiting, and stomatitis have been reported, very few cases of MTX-induced neutropenia have been found in the literature. We have taken a case of neutropenia that developed after the patient took tablet MTX for RA. The case was studied and the causality assessment of the reported adverse drug reaction showed it to be in the category of “probable” according to the WHO-UMC causality categories.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"3 1","pages":"105 - 107"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89667724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_89_22
A. Tom, J. Mandumpala, Aleena Manoj, Neha Maria Baby, S. Mathai, Siji Antony
Background: Identification of drug-related problems (DRPs) is a medication management service that can add value to individual patient care. Determination of DRPs daily is a promising approach for optimizing treatment. Objective: The objective of this study was to analyze the incidence of DRPs identified along with the risk factors that contribute to its development. Setting: This study was conducted in a tertiary care hospital in Central Kerala, India. Methods: A cross-sectional study was conducted among 300 newly admitted patients to the general medicine department. Patient medical records were reviewed in 3 stages – medication reconciliation, medication order review, and discharge summary review, and DRPs were categorized based on the Pharmaceutical Care Network Europe V9.1. Patient characteristics such as age, gender, polypharmacy, comorbidities, nonadherence, and type of illness were recorded. Results: Out of 300 patients, 78.7% had DRPs. The incidence of DRPs was found to be 0.26 cases/people-months. Although age >60 years, gender, polypharmacy, nonadherence, comorbidities, and chronic ailments were risk factors for DRPs, only polypharmacy and comorbidities could be proven statistically. Conclusion: DRPs are an emerging issue within the confines of the health-care system and should be scrutinized to avoid negative outcomes. A stage-wise analysis of patients who are at risk will ensure better patient care.
背景:药物相关问题识别(DRPs)是一项药物管理服务，可以为个体患者护理增加价值。每日测定DRPs是一种很有前途的优化治疗方法。目的:本研究的目的是分析已确定的DRPs的发生率及其发展的危险因素。环境:本研究在印度喀拉拉邦中部的一家三级保健医院进行。方法:对300例普通内科新住院患者进行横断面研究。患者医疗记录分为3个阶段进行审查——药物核对、医嘱审查和出院摘要审查，drp基于Pharmaceutical Care Network Europe V9.1进行分类。记录患者的年龄、性别、多种药物、合并症、不依从性和疾病类型等特征。结果:300例患者中，78.7%发生DRPs。DRPs的发生率为0.26例/人-月。虽然年龄>60岁、性别、多种用药、不依从、合并症和慢性病是DRPs的危险因素，但只有多种用药和合并症能得到统计学证实。结论:drp是卫生保健系统范围内的一个新问题，应仔细审查以避免负面后果。对处于危险中的患者进行分阶段分析将确保对患者进行更好的护理。
{"title":"Drug-related Problems among Inpatients of General Medicine Department of a Tertiary Care Hospital in South India","authors":"A. Tom, J. Mandumpala, Aleena Manoj, Neha Maria Baby, S. Mathai, Siji Antony","doi":"10.4103/ajprhc.ajprhc_89_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_89_22","url":null,"abstract":"Background: Identification of drug-related problems (DRPs) is a medication management service that can add value to individual patient care. Determination of DRPs daily is a promising approach for optimizing treatment. Objective: The objective of this study was to analyze the incidence of DRPs identified along with the risk factors that contribute to its development. Setting: This study was conducted in a tertiary care hospital in Central Kerala, India. Methods: A cross-sectional study was conducted among 300 newly admitted patients to the general medicine department. Patient medical records were reviewed in 3 stages – medication reconciliation, medication order review, and discharge summary review, and DRPs were categorized based on the Pharmaceutical Care Network Europe V9.1. Patient characteristics such as age, gender, polypharmacy, comorbidities, nonadherence, and type of illness were recorded. Results: Out of 300 patients, 78.7% had DRPs. The incidence of DRPs was found to be 0.26 cases/people-months. Although age >60 years, gender, polypharmacy, nonadherence, comorbidities, and chronic ailments were risk factors for DRPs, only polypharmacy and comorbidities could be proven statistically. Conclusion: DRPs are an emerging issue within the confines of the health-care system and should be scrutinized to avoid negative outcomes. A stage-wise analysis of patients who are at risk will ensure better patient care.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"32 1","pages":"22 - 28"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85493514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Despite being uncommon, pilon fractures are of interest to orthopedic surgeons because of the awkwardness of their treatment. Although various surgical techniques were used, poor outcomes are frequently encountered, and complications are highly prevalent. Objective: The objective of this study was to evaluate the clinical and radiographic outcomes of pilon fractures treated with a two-stage technique. Materials and Methods: The study included patients with tibial pilon fractures who had undergone two-stage procedures in King Saud Medical City (April 2017–March 2022). Fractures were categorized based on the Arbeitsgemeinschaftfur Osteosynthesefragen (AO) classification method. Outcomes were measured by the American Orthopedic Foot and Ankle Society (AOFAS) scoring system. Results: Twenty-one patients had tibial pilon fracture. Open fractures were seen in 23.8%, the majority was Gustilo type II in 60%. The mean follow-up was 24.7 months. The majority (47.6%) was AO type 43-B. Osteoarthritis was developed in 61.9%, and none mandates arthrodesis. Mean AOFAS was 86.91 points, it was excellent in 38.1%. Type 43 C fracture significantly had a poorer AOFAS score (P = 0.021). AOFAS score was significantly affected by fracture grade and association with fibular fracture, P = 0.025, and P = 0.019, respectively. Conclusion: Treatment for severe pilon fractures with a two-stage protocol yields favorable outcomes. Fewer soft-tissue complications and better articular reconstruction were the main benefits.
背景:尽管不常见，但由于其治疗的尴尬，骨科医生对枕部骨折很感兴趣。虽然使用了各种手术技术，但经常遇到不良结果，并发症非常普遍。目的:本研究的目的是评估两阶段技术治疗枕部骨折的临床和影像学结果。材料和方法:该研究纳入了在沙特国王医疗城(King Saud Medical City)接受两阶段手术的胫骨pilon骨折患者(2017年4月- 2022年3月)。骨折的分类基于Arbeitsgemeinschaftfur osteosynthesis efragen (AO)分类方法。结果由美国骨科足踝学会(AOFAS)评分系统测量。结果:21例患者发生胫骨pilon骨折。开放性骨折占23.8%，以II型Gustilo为主，占60%。平均随访时间为24.7个月。43-B型AO占多数(47.6%)。61.9%的患者有骨关节炎，没有一例需要关节融合术。平均AOFAS为86.91分，优秀者占38.1%。43 C型骨折的AOFAS评分明显较低(P = 0.021)。骨折分级及与腓骨骨折的相关性对AOFAS评分有显著影响，P = 0.025, P = 0.019。结论:采用两阶段方案治疗严重枕部骨折效果良好。较少的软组织并发症和更好的关节重建是主要的好处。
{"title":"Management and outcomes of high-energy pilon fractures: A case of King Saud Medical City, KSA","authors":"SaadeldinAhmed Idris, AhmedOnayzan Alshammari, AhmedMohammed Ahmed Abdalrahman, Hani Serhan, MajedMouaffek Majed Shogair, Hussain Alyassain, BashahMohammad Saleh Almustanir, HaniNouran Alharbi, Fahd Alshahrani, MashaelSultan Alsadoon, AbdulmohsinAdnan Alhabobi","doi":"10.4103/ajprhc.ajprhc_102_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_102_23","url":null,"abstract":"Background: Despite being uncommon, pilon fractures are of interest to orthopedic surgeons because of the awkwardness of their treatment. Although various surgical techniques were used, poor outcomes are frequently encountered, and complications are highly prevalent. Objective: The objective of this study was to evaluate the clinical and radiographic outcomes of pilon fractures treated with a two-stage technique. Materials and Methods: The study included patients with tibial pilon fractures who had undergone two-stage procedures in King Saud Medical City (April 2017–March 2022). Fractures were categorized based on the Arbeitsgemeinschaftfur Osteosynthesefragen (AO) classification method. Outcomes were measured by the American Orthopedic Foot and Ankle Society (AOFAS) scoring system. Results: Twenty-one patients had tibial pilon fracture. Open fractures were seen in 23.8%, the majority was Gustilo type II in 60%. The mean follow-up was 24.7 months. The majority (47.6%) was AO type 43-B. Osteoarthritis was developed in 61.9%, and none mandates arthrodesis. Mean AOFAS was 86.91 points, it was excellent in 38.1%. Type 43 C fracture significantly had a poorer AOFAS score (P = 0.021). AOFAS score was significantly affected by fracture grade and association with fibular fracture, P = 0.025, and P = 0.019, respectively. Conclusion: Treatment for severe pilon fractures with a two-stage protocol yields favorable outcomes. Fewer soft-tissue complications and better articular reconstruction were the main benefits.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"157 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135104440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_61_23
NessrinGhazi Alabdallat, Hana Alanazi
Aims: The aim of the study was to estimate the antioxidant characteristics of methanolic and acetone extracts of Pistacia palaestina, Verbena triphylla, and Nigella sativa. Materials and Methods: The biochemical antioxidant assays that used were total phenols and flavonoids, total antioxidant capacity, ferric reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging. Results: The maximum antioxidant capacity and the ferric-reducing power of the examined plant extracts were shown in P. palaestina/methanol whereas N. sativa L./methanol was the lowest. The maximum scavenging activity of DPPH was shown in N. sativa L./acetone (IC50 = 2688 μg/ml), followed by, V. triphylla/acetone (IC50 = 573.5 μg/ml), N. sativa/methanol (IC50 = 437.7 μg/ml), V. triphylla/methanol (IC50 = 64 μg/ml), and P. palaestina methanol and acetone extracts (IC50 = 9.5 μ/g) being the lowest. Conclusion: The findings with methanol extract of P. palaestina methanol shown the highest antioxidant property which and can be due to the presence of high quantity of phenols and flavonoids in the methanol extract of this plant; moreover, N. sativa acetone extract has maximum DPPH-free radical scavenging activity. This may be because the acetone extract demonstrated capabilities to scavenge radicals remarkably for Nigella sativa L seeds.
{"title":"Antioxidant Properties of Methanolic and Acetone Extracts of Pictacia palaestina, Verbena triphylla and Nigella sativum","authors":"NessrinGhazi Alabdallat, Hana Alanazi","doi":"10.4103/ajprhc.ajprhc_61_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_61_23","url":null,"abstract":"Aims: The aim of the study was to estimate the antioxidant characteristics of methanolic and acetone extracts of Pistacia palaestina, Verbena triphylla, and Nigella sativa. Materials and Methods: The biochemical antioxidant assays that used were total phenols and flavonoids, total antioxidant capacity, ferric reducing power and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging. Results: The maximum antioxidant capacity and the ferric-reducing power of the examined plant extracts were shown in P. palaestina/methanol whereas N. sativa L./methanol was the lowest. The maximum scavenging activity of DPPH was shown in N. sativa L./acetone (IC50 = 2688 μg/ml), followed by, V. triphylla/acetone (IC50 = 573.5 μg/ml), N. sativa/methanol (IC50 = 437.7 μg/ml), V. triphylla/methanol (IC50 = 64 μg/ml), and P. palaestina methanol and acetone extracts (IC50 = 9.5 μ/g) being the lowest. Conclusion: The findings with methanol extract of P. palaestina methanol shown the highest antioxidant property which and can be due to the presence of high quantity of phenols and flavonoids in the methanol extract of this plant; moreover, N. sativa acetone extract has maximum DPPH-free radical scavenging activity. This may be because the acetone extract demonstrated capabilities to scavenge radicals remarkably for Nigella sativa L seeds.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_98_23
Swathi Acharya, Ananyaa Agrawal
Context: Surgical site infections (SSIs) are the second-most common cause of health care-associated infections and are responsible for postoperative illness leading to increased morbidity and mortality. There are various preventive strategies against SSIs such as proper surgical technique, strict asepsis in the operating theater, control of infection within the hospital or general practice, and antibiotic prophylaxis. Widespread use of prophylactic antibiotics has the disadvantage of the emergence of multiresistant organisms. Thus, the implementation of proper surgical antimicrobial prophylaxis (SAP) practice is highly recommended to assess the pattern of SAP practiced in a tertiary care hospital in southern India. Subjects and Methods: A prospective, observational, cross-sectional study was conducted in a tertiary care hospital where data were collected from 175 inpatients admitted to the surgical ward. The pattern of SAP practice was analyzed using descriptive statistics. Results: The pattern of antibiotic prophylaxis revealed that the most commonly used agents were third-generation cephalosporins (57.71%), followed by broad-spectrum penicillins (18.86%), second-generation cephalosporins (13.71%), fluoroquinolones (4.57%), and antiamebic drugs (13.14%) mainly for gastrointestinal surgeries. Conclusions: Assessing the pattern of antimicrobial prophylaxis will help us to determine the appropriateness of the drugs prescribed with respect to the procedure and will help us to give feedback to the clinician and policymakers regarding the need for improvement in case of deviation in the practice compared to the guidelines given in the hospital antibiotic policy.
{"title":"Assessment of antimicrobial prophylaxis in surgical procedures in a tertiary care hospital in Southern India: A cross-sectional study","authors":"Swathi Acharya, Ananyaa Agrawal","doi":"10.4103/ajprhc.ajprhc_98_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_98_23","url":null,"abstract":"Context: Surgical site infections (SSIs) are the second-most common cause of health care-associated infections and are responsible for postoperative illness leading to increased morbidity and mortality. There are various preventive strategies against SSIs such as proper surgical technique, strict asepsis in the operating theater, control of infection within the hospital or general practice, and antibiotic prophylaxis. Widespread use of prophylactic antibiotics has the disadvantage of the emergence of multiresistant organisms. Thus, the implementation of proper surgical antimicrobial prophylaxis (SAP) practice is highly recommended to assess the pattern of SAP practiced in a tertiary care hospital in southern India. Subjects and Methods: A prospective, observational, cross-sectional study was conducted in a tertiary care hospital where data were collected from 175 inpatients admitted to the surgical ward. The pattern of SAP practice was analyzed using descriptive statistics. Results: The pattern of antibiotic prophylaxis revealed that the most commonly used agents were third-generation cephalosporins (57.71%), followed by broad-spectrum penicillins (18.86%), second-generation cephalosporins (13.71%), fluoroquinolones (4.57%), and antiamebic drugs (13.14%) mainly for gastrointestinal surgeries. Conclusions: Assessing the pattern of antimicrobial prophylaxis will help us to determine the appropriateness of the drugs prescribed with respect to the procedure and will help us to give feedback to the clinician and policymakers regarding the need for improvement in case of deviation in the practice compared to the guidelines given in the hospital antibiotic policy.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135106191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_13_23
L. P. Low, F. Islahudin, S. Saffian
Context: Anticoagulants are used to prevent and treat venous thromboembolism (VTE), such as deep-vein thrombosis (DVT) and pulmonary embolism (PE) in COVID-19 for better outcomes. Aim: This study aims to explore clinical outcomes and factors affecting VTE among COVID-19 patients. Settings and Design: The study design involved a retrospective cohort study. Study Methods: Hospitalized COVID-19 patients in a tertiary hospital prescribed subcutaneous (SC) anticoagulants were included. Statistical Analysis Used: Multiple logistic regression was performed to determine factors affecting VTE among subjects. Results: A total of 450 patients were included. Types of anticoagulants include fondaparinux (n = 114, 38.1%), enoxaparin (n = 113, 37.8%), and heparin (n = 72, 24.1%). 423 (94.0%) patients were discharged well, 27 (6.0%) patients were admitted to the intensive care unit (ICU). The primary outcome was the prevalence of VTE, which occurred in 19.3% (n = 87) patients, with 80 (92.0%) reporting DVT and 7 (8.0%) reporting PE. The secondary outcome, which was the average length of hospital stay was 9.9 (±4.7) days. Factors of VTE occurrence were likely in patients not prescribed SC anticoagulants compared to those prescribed with SC anticoagulants (adjusted odds ratio [aOR] 54.330, 95% confidence interval [CI]: 7.086, 416.526), treatment with fondaparinux compared to heparin (aOR 2.502, 95% CI: 1.175, 5.327), and less likely in those discharged well compared to patients in the ICU (aOR 0.139, 95% CI: 0.053, 0.361). Conclusions: Careful monitoring is required to reduce VTE risk in COVID-19 patients.
{"title":"Factors of venous thromboembolism among COVID-19 patients","authors":"L. P. Low, F. Islahudin, S. Saffian","doi":"10.4103/ajprhc.ajprhc_13_23","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_13_23","url":null,"abstract":"Context: Anticoagulants are used to prevent and treat venous thromboembolism (VTE), such as deep-vein thrombosis (DVT) and pulmonary embolism (PE) in COVID-19 for better outcomes. Aim: This study aims to explore clinical outcomes and factors affecting VTE among COVID-19 patients. Settings and Design: The study design involved a retrospective cohort study. Study Methods: Hospitalized COVID-19 patients in a tertiary hospital prescribed subcutaneous (SC) anticoagulants were included. Statistical Analysis Used: Multiple logistic regression was performed to determine factors affecting VTE among subjects. Results: A total of 450 patients were included. Types of anticoagulants include fondaparinux (n = 114, 38.1%), enoxaparin (n = 113, 37.8%), and heparin (n = 72, 24.1%). 423 (94.0%) patients were discharged well, 27 (6.0%) patients were admitted to the intensive care unit (ICU). The primary outcome was the prevalence of VTE, which occurred in 19.3% (n = 87) patients, with 80 (92.0%) reporting DVT and 7 (8.0%) reporting PE. The secondary outcome, which was the average length of hospital stay was 9.9 (±4.7) days. Factors of VTE occurrence were likely in patients not prescribed SC anticoagulants compared to those prescribed with SC anticoagulants (adjusted odds ratio [aOR] 54.330, 95% confidence interval [CI]: 7.086, 416.526), treatment with fondaparinux compared to heparin (aOR 2.502, 95% CI: 1.175, 5.327), and less likely in those discharged well compared to patients in the ICU (aOR 0.139, 95% CI: 0.053, 0.361). Conclusions: Careful monitoring is required to reduce VTE risk in COVID-19 patients.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"5 1","pages":"97 - 104"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74181666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_102_22
Rishita Rai, Sudhakar Subramanian
Background: It is crucial to understand diastasis rectus abdominis (DRA) in postpartum women and how it affects them. DRA should be related to pelvic floor dysfunction (PFD) and low back pain (LBP). Prior researchers have contradictory findings in their studies. Objective: To estimate the prevalence of DRA and find the association between LBP, PFD, and DRA. Methodology: According to the eligibility criteria, 102 participants from Bengaluru were chosen for this study. The physical screening was performed to rule out DRA. Following informed consent, the participants have given the Oswestry Disability Index Questionnaire for LBP and Pelvic Floor Impact Questionnaire-7 for PFD. Subjects were divided into two classes: case and control. The data were analyzed using the Chi-square test and the Odds ratio using SPSS Software. Results: This analysis presents the findings of the prevalence of DRA and also the findings of rated LBP and PFD in both the groups. The degree of impact was determined to be P < 0.05. Conclusion: As an outcome, there is an association between LBP, PFD, and DRA.
{"title":"Association between low back pain, pelvic floor dysfunction, and diastasis rectus abdominis in postnatal delivery women","authors":"Rishita Rai, Sudhakar Subramanian","doi":"10.4103/ajprhc.ajprhc_102_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_102_22","url":null,"abstract":"Background: It is crucial to understand diastasis rectus abdominis (DRA) in postpartum women and how it affects them. DRA should be related to pelvic floor dysfunction (PFD) and low back pain (LBP). Prior researchers have contradictory findings in their studies. Objective: To estimate the prevalence of DRA and find the association between LBP, PFD, and DRA. Methodology: According to the eligibility criteria, 102 participants from Bengaluru were chosen for this study. The physical screening was performed to rule out DRA. Following informed consent, the participants have given the Oswestry Disability Index Questionnaire for LBP and Pelvic Floor Impact Questionnaire-7 for PFD. Subjects were divided into two classes: case and control. The data were analyzed using the Chi-square test and the Odds ratio using SPSS Software. Results: This analysis presents the findings of the prevalence of DRA and also the findings of rated LBP and PFD in both the groups. The degree of impact was determined to be P < 0.05. Conclusion: As an outcome, there is an association between LBP, PFD, and DRA.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"15 1","pages":"16 - 21"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87791877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.4103/ajprhc.ajprhc_85_22
N. Patel, Rupali R. Bavikar, Y. Ingale, Yesha Lad, Arpana A. Dharwadkar, V. Viswanathan
Introduction: For intra-operative diagnosis of ovarian tumors, imprint cytology is the method which gives result within 20 min. It does not affect the quality and utility of the specimen for histopathology. Despite advances in genetics and imaging, histopathological analysis remains the mainstay of ovarian tumor diagnosis. Aim: To describe incidence, age distribution, histological characteristics and whenever feasible, correlate the histopathological diagnosis of ovarian tumors with the imprint cytology technique. Materials and Methods: A total of 200 patients with ovarian tumors were included in this ambispective study from January 2017 to April 2022 at the Dr. D. Y. Patil Medical College, Hospital and Research Center, Pimpri. Results: One hundred and forty-eight (74%) of the 200 cases were benign, while 52 (26%) were malignant. The peak age incidence of benign tumors was in the second to fourth decades and malignant ovarian tumors was in fourth to sixth decades. Ovarian tumors involved the left ovary (n = 104, 52%) more than the right ovary (n = 90, 45%). Out of 200 cases, 130 cases (65%) were surface epithelial ovarian tumors, followed by 50 cases (25%) were germ cell tumors, followed by 14 cases (7%) were sex cord stromal tumors followed by 3 cases (3%) were secondary/metastatic tumors of ovary. Imprint cytology technique done on 148 cases (74%) showed 100% correlation with the histopathological diagnosis. Conclusion: Imprint cytology diagnosis correlated with the histopathological diagnosis of ovarian tumors.
对于卵巢肿瘤的术中诊断，印迹细胞学是在20分钟内给出结果的方法，它不影响组织病理学标本的质量和效用。尽管在遗传学和影像学方面取得了进展，但组织病理学分析仍然是卵巢肿瘤诊断的主要手段。目的:描述卵巢肿瘤的发病率、年龄分布、组织学特征，并在可行的情况下将组织病理学诊断与印迹细胞学技术联系起来。材料和方法:2017年1月至2022年4月，共有200例卵巢肿瘤患者在皮姆普里的Dr. D. Y. Patil医学院医院和研究中心接受了这项双侧研究。结果:200例中，良性148例(74%)，恶性52例(26%)。良性肿瘤的发病高峰在20 ~ 40岁，恶性肿瘤的发病高峰在40 ~ 60岁。卵巢肿瘤累及左卵巢(n = 104, 52%)多于累及右卵巢(n = 90, 45%)。200例中，卵巢表面上皮性肿瘤130例(65%)，生殖细胞性肿瘤50例(25%)，性索间质性肿瘤14例(7%)，卵巢继发性/转移性肿瘤3例(3%)。148例(74%)印迹细胞学技术与组织病理学诊断的相关性为100%。结论:印迹细胞学诊断与卵巢肿瘤的组织病理学诊断相关。
{"title":"ClinicoPathological Overview of Ovarian Tumors and Diagnostic Utility of Imprint Cytology","authors":"N. Patel, Rupali R. Bavikar, Y. Ingale, Yesha Lad, Arpana A. Dharwadkar, V. Viswanathan","doi":"10.4103/ajprhc.ajprhc_85_22","DOIUrl":"https://doi.org/10.4103/ajprhc.ajprhc_85_22","url":null,"abstract":"Introduction: For intra-operative diagnosis of ovarian tumors, imprint cytology is the method which gives result within 20 min. It does not affect the quality and utility of the specimen for histopathology. Despite advances in genetics and imaging, histopathological analysis remains the mainstay of ovarian tumor diagnosis. Aim: To describe incidence, age distribution, histological characteristics and whenever feasible, correlate the histopathological diagnosis of ovarian tumors with the imprint cytology technique. Materials and Methods: A total of 200 patients with ovarian tumors were included in this ambispective study from January 2017 to April 2022 at the Dr. D. Y. Patil Medical College, Hospital and Research Center, Pimpri. Results: One hundred and forty-eight (74%) of the 200 cases were benign, while 52 (26%) were malignant. The peak age incidence of benign tumors was in the second to fourth decades and malignant ovarian tumors was in fourth to sixth decades. Ovarian tumors involved the left ovary (n = 104, 52%) more than the right ovary (n = 90, 45%). Out of 200 cases, 130 cases (65%) were surface epithelial ovarian tumors, followed by 50 cases (25%) were germ cell tumors, followed by 14 cases (7%) were sex cord stromal tumors followed by 3 cases (3%) were secondary/metastatic tumors of ovary. Imprint cytology technique done on 148 cases (74%) showed 100% correlation with the histopathological diagnosis. Conclusion: Imprint cytology diagnosis correlated with the histopathological diagnosis of ovarian tumors.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"30 1","pages":"11 - 15"},"PeriodicalIF":0.4,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79524469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maternal mortality rate (MMR) consistently becomes a hot topic from day to day because there isn't a bright hope or the best exit door. Definition of maternal death according to World Health Organization (WHO) is the death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management but not from accidental or incidental causes. The amount of maternal death related to pregnancy has constantly been escalating from day to day since many decades ago. In the event of discussion at the Health Department of East Java Province in November ago, the data was alarming about a great problem related to maternal death in Indonesia.
{"title":"Maternal Mortality in Indonesia, Ask for Help","authors":"S. Sutrisno","doi":"10.55561/ajhr.v1i3.84","DOIUrl":"https://doi.org/10.55561/ajhr.v1i3.84","url":null,"abstract":"Maternal mortality rate (MMR) consistently becomes a hot topic from day to day because there isn't a bright hope or the best exit door. Definition of maternal death according to World Health Organization (WHO) is the death of a woman while pregnant or within 42 days of termination of pregnancy, irrespective of the duration and site of the pregnancy, from any cause related to or aggravated by the pregnancy or its management but not from accidental or incidental causes. The amount of maternal death related to pregnancy has constantly been escalating from day to day since many decades ago. In the event of discussion at the Health Department of East Java Province in November ago, the data was alarming about a great problem related to maternal death in Indonesia.","PeriodicalId":8534,"journal":{"name":"Asian Journal of Pharmaceutical Research and Health Care","volume":"67 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72875041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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